@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K6_HUMAN: (2015-10-14 )
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
Atome Classification :
(79 SA)
.........10........20........30........40........50....------...-.60........70........80........90........100.......110.......-----120-..------......130..--.-..-...140....-..----.150.......160.......170.......180.......190.......200...-------..-..210.--.-......-220......-.-230..-......240.......250....----------------.---..260-----------..------......270-.....--------------------..-..280------.---........290.......300.......310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQSKGKKRNPGLKI
P
K
E
A
FEQPQTSSTPPRDLD
S
K
A
C
ISIGNQ
N
F
E
V
KAD
D
L
E
P
------
I
M
E
-LGR
G
A
Y
G
V
V
E
K
M
R
HVPSG
Q
I
M
A
V
K
R
I
R
A
TVN
S
Q
E
Q
K
R
L
L
M
DLD
I
S
M
R
TVDC
P
F
T
V
T
F
Y
G
A
L
-----FR--EG------
D
V
W
I
C
M
E
-
L
M
D
--
T
-
S
L
-
D
K
F
Y
K
Q
V
I
DK-GQ----TI
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
HRDVKP
S
N
V
L
I
N
ALGQ
V
K
M
C
DFGIS
G
Y
L
V
-------
D
S
-
V
A
K
-
T
I
--D-AGCKPY-MAPERINP
E
-
L
-N-QKG-YS
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
RFP----------------Y---DSWG------------
T
P
------
F
Q
Q
L
K
Q
V
---
V
EEPS--------------------PQ-LP
A
--------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
KKNSKERPT
Y
P
E
L
M
QHP
F
F
T
L
HESKGT
D
V
A
S
F
V
K
L
I
LGD
120
HHSearch
88.95
99%
-125
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
---------------------------------------------
M
E
V
K
A
D
D
L
E
P
------
I
M
E
-
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
-
L
M
D
--
T
-
S
L
-
D
K
F
Y
K
Q
V
I
D
K
-
G
Q
----
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
---------------------------
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
---
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
---
V
E
E
P
S
--------------------
P
Q
-
L
P
A
--------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-
2
PsiBlast_PDB
88.73
98%
-125
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
---------------------------------------------
M
E
V
K
A
D
D
L
E
P
------
I
M
E
-
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
-
L
M
D
--
T
-
S
L
-
D
K
F
Y
K
Q
V
I
D
K
-
G
Q
----
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
---------------------------
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
---
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
---
V
E
E
P
S
--------------------
P
Q
-
L
P
A
--------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-
1
PsiBlast_PDB
86.80
100%
-114
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[44-334]
-------------------------------------------
Q
N
F
E
V
K
A
D
D
L
E
P
------
I
M
E
-
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
-
L
M
D
--
T
-
S
L
-
D
K
F
Y
K
Q
V
I
D
K
-
G
Q
----
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
-------
D
S
-
V
A
K
-
T
I
--
D
-
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
K
G
-
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
---
V
E
E
P
S
--------------------
P
Q
-
L
P
A
--------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
123
HHSearch
77.05
43%
-114
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[28-347]
---------------------------------------------
G
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
G-
G
-
S
L
-
D
Q
V
L
K
K
-----
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-------
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
P
D
A
K
E
L
E
L
M
F
GCPM
A
I
------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
16
PsiBlast_PDB
75.68
41%
-113
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[1-288]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP---
P
PM----------
A
I
------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
121
HHSearch
75.56
59%
-127
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[14-307]
------------------------------------------
E
Q
H
W
D
F
T
A
E
D
L
K
D
------
L
G
E
-
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
-
L
M
S
--
T
-
S
F
-
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
----
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
W
-------------------------
T
Q
V
---
V
K
G
D
P
--------------------
P
Q
-
L
S
N
--------
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
38
PsiBlast_CBE
75.38
37%
-124
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
23
PsiBlast_CBE
75.38
37%
-120
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
18
PsiBlast_PDB
75.24
37%
-121
- C1 -
2P55
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
21
PsiBlast_CBE
75.08
58%
-127
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[15-307]
-------------------------------------------
Q
H
W
D
F
T
A
E
D
L
K
D
------
L
G
E
-
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
-
L
M
S
--
T
-
S
F
-
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
----
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
----------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
------------------------------------
D
P
--------------------
P
Q
-
L
S
N
--------
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
4
PsiBlast_PDB
75.08
58%
-127
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[15-307]
-------------------------------------------
Q
H
W
D
F
T
A
E
D
L
K
D
------
L
G
E
-
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
-
L
M
S
--
T
-
S
F
-
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
----
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
W
-------------------------
T
Q
V
---
V
K
G
D
P
--------------------
P
Q
-
L
S
N
--------
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
20
PsiBlast_PDB
74.62
37%
-125
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
24
PsiBlast_CBE
73.98
37%
-121
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
47
PsiBlast_CBE
73.95
37%
-117
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
12
PsiBlast_PDB
73.94
42%
-114
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[5-281]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
E
-
M
A
N
-
E
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
M
A
------------
I
-------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
53
PsiBlast_CBE
73.87
37%
-118
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[27-345]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
36
PsiBlast_CBE
73.86
37%
-121
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
19
PsiBlast_PDB
73.79
37%
-122
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
35
PsiBlast_CBE
73.63
37%
-124
- C1 -
3V01
2
?
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
43
PsiBlast_CBE
73.53
37%
-117
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
49
PsiBlast_CBE
73.42
37%
-118
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[27-345]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
34
PsiBlast_CBE
73.39
37%
-125
- C1 -
3V04
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
29
PsiBlast_CBE
73.34
37%
-121
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
48
PsiBlast_CBE
73.30
37%
-119
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
51
PsiBlast_CBE
72.90
37%
-118
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[27-345]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
50
PsiBlast_CBE
72.79
37%
-116
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[27-345]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
---------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
40
PsiBlast_CBE
72.72
37%
-117
- C1 -
4U80
2
MP2K1_HUMAN
A:
[1-319]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--
39
PsiBlast_CBE
72.67
37%
-119
- C1 -
4U81
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
31
PsiBlast_CBE
72.62
37%
-115
- C1 -
3VVH
2
?
C:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDA--------------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
33
PsiBlast_CBE
72.61
37%
-121
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
----------
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDA
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
41
PsiBlast_CBE
72.58
37%
-117
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------PPMA
I
-
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
45
PsiBlast_CBE
72.39
37%
-119
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
5
PsiBlast_PDB
72.23
58%
-120
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[17-307]
---------------------------------------------
W
D
F
T
A
E
D
L
K
D
------
L
G
E
-
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
-
L
M
S
--
T
-
S
F
-
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
----
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
-------
D
S
-
I
A
K
-
T
R
--
D
-
A
G
C
R
P
Y
-
M
A
P
E
R
I
D
P
----------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
W
N
------------
S
V
------
F
D
Q
L
T
Q
V
---
V
K
G
D
P
--------------------
P
Q
-
L
S
N
--------
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
44
PsiBlast_CBE
72.15
37%
-118
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
9
PsiBlast_PDB
72.03
42%
-119
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[21-301]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
---------------
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
G
-----------------A
I
----
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
30
PsiBlast_CBE
71.78
37%
-121
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMF-------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
37
PsiBlast_CBE
71.72
37%
-122
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPP----------------------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-----------------
32
PsiBlast_CBE
71.20
37%
-114
- C1 -
3VVH
2
?
B:
[1-320]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F-------------------------MA
I
---
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
11
PsiBlast_PDB
71.12
42%
-113
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[5-281]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
E
-
M
A
N
-
E
------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
M
A
------------
I
-------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
46
PsiBlast_CBE
71.05
37%
-121
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[29-347]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
13
PsiBlast_PDB
71.02
42%
-117
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[5-281]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
E
-
M
A
N
-
E
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
M
A
------------
I
-------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
52
PsiBlast_CBE
70.81
37%
-122
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[27-345]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------------------PMA
I
--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
42
PsiBlast_CBE
69.11
37%
-119
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[24-342]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GCQ----------------------RPPMA
I
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
14
PsiBlast_PDB
69.08
41%
-111
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[1-288]
---------------------------------------------
M
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP----PM----------
A
I
------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
10
PsiBlast_PDB
68.90
42%
-115
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[5-281]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
E
-
M
A
N
-
E
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
M
A
------------
I
-------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
17
PsiBlast_PDB
66.11
37%
-114
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[64-382]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMFGC-----------------------PMAI--
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
S
--------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
15
PsiBlast_PDB
65.30
41%
-115
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
----------------------------------------------
E
L
K
D
D
D
F
E
K
------
I
S
E
-
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
-
H
M
D
--
G
G
S
L
-
D
----
Q
V
L
K
K
-
A
G
----
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
D
S
-
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
P------M-----------
A
I
------
F
E
L
L
D
Y
I
---
V
N
E
P
P
--------------------
P
K
-
L
P
-------------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
---
72
PsiBlast_CBE
57.80
31%
-105
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[5-286]
---------------------------------------------
W
S
I
N
R
D
D
Y
E
L
------
Q
E
V
-
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
-----
V
V
--
K
D
------
E
L
W
L
V
M
K
-
L
L
S
--
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
-
G
E
HKSG
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD----------
T
F
----
V
G
T
P
C
W
-
M
A
P
E
V
M
E
-----
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
----------------
Y
---
H
K
Y
-------------
P
P
------
M
K
V
L
M
L
T
---
L
Q
N
D
P
--------------------
P
S
-
L
E
T
GVQDKEML
K
---
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------
125
HHSearch
57.50
35%
-96
* C1 *
4OBO
2
M4K4_HUMAN
A:
[22-294]
------------------------------------------------
P
A
G
I
F
E
L
------
V
E
V
-
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
-----
I
K
K
S
D
D
------
Q
L
W
L
V
M
E
-
F
C
G
--
A
G
S
I
-
T
D
L
V
K
N
--
T
K
-
G
N
----
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-------------------R
N
T
--
F
-
I
G
T
P
Y
W
-
M
A
P
E
V
I
A
C
D
-
E
-
N
P
D
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
M
-------------
H
P
------
M
R
A
L
F
L
I
---
P
R
N
P
P
--------------------
P
R
-
L
K
S
--------
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
73
PsiBlast_CBE
57.32
31%
-107
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[5-286]
---------------------------------------------
W
S
I
N
R
D
D
Y
E
L
------
Q
E
V
-
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
-----
V
V
--
K
D
------
E
L
W
L
V
M
K
-
L
L
S
--
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
-
G
E
HKSG
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD------------------
T
P
C
W
-
M
A
P
E
V
M
E
-----
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
----------------
Y
---
H
K
Y
-------------
P
P
------
M
K
V
L
M
L
T
---
L
Q
N
D
P
--------------------
P
S
-
L
E
T
GVQDKEML
K
---
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------
74
PsiBlast_CBE
57.27
31%
-105
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[5-286]
---------------------------------------------
W
S
I
N
R
D
D
Y
E
L
------
Q
E
V
-
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
-----
V
V
--
K
D
------
E
L
W
L
V
M
K
-
L
L
S
--
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
-
G
E
HKSG
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-----------------
V
G
T
P
C
W
-
M
A
P
E
V
M
E
-----
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
----------------
Y
---
H
K
Y
-------------
P
P
------
M
K
V
L
M
L
T
---
L
Q
N
D
P
--------------------
P
S
-
L
E
T
GVQDKEML
K
---
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------
71
PsiBlast_CBE
56.57
31%
-107
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[5-286]
---------------------------------------------
W
S
I
N
R
D
D
Y
E
L
------
Q
E
V
-
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
-----
V
V
--
K
D
------
E
L
W
L
V
M
K
-
L
L
S
--
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
-
G
E
HKSG
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGDITR
N
-------
F
----
V
G
T
P
C
W
-
M
A
P
E
V
M
E
-----
Q
-
V
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
----------------
Y
---
H
K
Y
-------------
P
P
------
M
K
V
L
M
L
T
---
L
Q
N
D
P
--------------------
P
S
-
L
E
T
GVQDKEML
K
---
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------
78
PsiBlast_CBE
55.94
33%
-91
- C1 -
4U44
2
M4K4_HUMAN
A:
[13-290]
---------------------------------------
D
I
D
L
S
S
L
R
D
P
A
G
I
F
E
L
------
V
E
V
-
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
HD
D
---
Q
L
W
L
V
M
E
-
F
C
G
--
A
G
S
I
-
T
D
L
V
K
N
T
--
K
-
G
N
----
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------------
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
M
-------------
H
P
------
M
R
A
L
F
L
I
---
P
R
N
P
P
--------------------
P
R
-
L
K
S
--------
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
77
PsiBlast_CBE
55.67
33%
-92
- C1 -
4U45
1
M4K4_HUMAN
A:
[13-290]
---------------------------------------
D
I
D
L
S
S
L
R
D
P
A
G
I
F
E
L
------
V
E
V
-
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
PPD
D
--
Q
L
W
L
V
M
E
-
F
C
G
--
A
G
S
I
-
T
D
L
V
K
N
T
--
K
-
G
N
----
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------------
N
--
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
M
-------------
H
P
------
M
R
A
L
F
L
I
---
P
R
N
P
P
--------------------
P
R
-
L
K
S
--------
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
79
PsiBlast_CBE
55.33
33%
-93
- C1 -
4U43
1
M4K4_HUMAN
A:
[15-290]
-----------------------------------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
------
V
E
V
-
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
-
F
C
G
--
A
G
S
I
-
T
D
L
V
K
N
T
--
K
-
G
N
----
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------------
N
--
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
M
-------------
H
P
------
M
R
A
L
F
L
I
---
P
R
N
P
P
--------------------
P
R
-
L
K
S
--------
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
139
HHSearch
53.88
30%
-96
- C1 -
2B9H
1
FUS3_YEAST
A:
[11-313]
--------------------------------------------------
S
D
F
Q
L
------
K
S
L
-
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
-
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
RPDSF
E
N
--
F
N
------
E
V
Y
I
I
Q
E
-
L
M
Q
--
T
-
D
L
-
H
R
V
I
S
T
------
Q
----
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
-
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------------V
E
F
-
V
A
T
R
W
Y
-
R
A
P
E
V
M
----
L
-
T
-
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
----------------
F
---
P
G
R
D
-------------
Y
------
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
SDNDLRCIES
P
R
A
R
E
Y
I
K
S
L
P
M
-
Y
P
A
AP
L
E
K
M
F
-
P
---
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
131
HHSearch
53.48
33%
-104
- C1 -
2J7T
1
STK10_HUMAN
A:
[23-285]
------------------------------------------------------
I
------
V
G
E
-
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
G
A
V
-
D
A
I
M
L
E
---
L
-
D
R
----
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------
K
T
-
L
Q
K
-------
I
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
-
T
M
K
-
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
-------------
N
P
------
M
R
V
L
L
K
I
---
A
K
S
D
P
--------------------
P
T
L
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
97
PsiBlast_CBE
50.50
32%
-98
- C1 -
4O0R
1
PAK1_HUMAN
A:
[27-275]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
P
E
-
Q
S
K
-
R
S
--
E
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
100
PsiBlast_CBE
49.80
31%
-89
- C1 -
4FZA
3
STK26_HUMAN
B:
[16-274]
-----------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
-----
L
K
--
G
S
------
K
L
W
I
I
M
E
-
Y
L
G
GG
S
-
A
L
-
D
L
L
R
A
G
P
F
D
E
-
F
Q
----------
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-------
D
T
Q
I
K
R
-
N
T
--
F
-
V
G
T
P
F
W
-
M
A
P
E
V
I
------
Q
-
Q
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
-
P
----------------
P
---
N
S
D
M
------------
H
P
------
M
R
V
L
F
L
I
---
P
K
N
N
P
--------------------
P
T
-
L
V
G
--------
D
----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
64
PsiBlast_CBE
48.98
33%
-88
- C1 -
4EQU
2
STK10_HUMAN
B:
[9-280]
----------------------------------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
63
PsiBlast_CBE
48.56
33%
-83
- C1 -
4USD
1
?
B:
[9-280]
----------------------------------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
---------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
67
PsiBlast_CBE
47.16
33%
-87
- C1 -
4AOT
1
STK10_HUMAN
A:
[5-280]
------------------------------------------
S
R
E
Y
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
91
PsiBlast_CBE
46.78
32%
-96
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
--
65
PsiBlast_CBE
46.67
33%
-88
- C1 -
4EQU
2
STK10_HUMAN
A:
[9-280]
----------------------------------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
107
PsiBlast_CBE
45.91
32%
-98
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[28-276]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
P
E
-
Q
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
98
PsiBlast_CBE
45.86
31%
-90
- C1 -
4FZF
1
?
B:
[16-274]
-----------------------------------------------------------------
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
-----
L
K
--
G
S
------
K
L
W
I
I
M
E
-
Y
L
G
GG
S
-
A
L
-
D
L
L
R
A
G
P
F
D
E
-
F
Q
----------
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-------
D
T
Q
I
K
R
-
N
T
--
F
-
V
G
T
P
F
W
-
M
A
P
E
V
I
------
Q
-
Q
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
-
P
----------------
P
---
N
S
D
M
------------
H
P
------
M
R
V
L
F
L
I
---
P
K
N
N
P
--------------------
P
T
-
L
V
G
--------
D
----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
105
PsiBlast_CBE
45.35
32%
-94
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[28-276]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
P
E
-
Q
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
90
PsiBlast_CBE
45.30
32%
-98
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
--
103
PsiBlast_CBE
45.05
32%
-98
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[28-276]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
----------------
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
87
PsiBlast_CBE
44.04
31%
-85
- C1 -
4O27
1
STK24_HUMAN
B:
[13-272]
---------------------------------------------------------------
K
-
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
-----
L
K
--
D
T
------
K
L
W
I
I
M
E
-
Y
L
G
GG
S
-
A
L
-
D
L
L
E
P
G
P
L
D
E
-
T
Q
----------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-------
D
T
-
Q
I
K
-
R
N
--
E
F
V
G
T
P
F
W
-
M
A
P
E
V
I
------
K
-
Q
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
----------------
H
---
S
E
L
-------------
H
P
------
M
K
V
L
F
L
I
---
P
K
N
N
P
--------------------
P
T
-
L
E
G
--------
N
----
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
62
PsiBlast_CBE
43.81
33%
-82
- C1 -
4USE
1
?
A:
[9-280]
----------------------------------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------
K
T
-
L
Q
-----------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
86
PsiBlast_CBE
43.48
31%
-90
- C1 -
3GGF
1
STK26_HUMAN
A:
[18-289]
----------------------------------------------
I
A
D
P
E
E
L
F
T
------
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
-----
L
K
--
G
S
------
K
L
W
I
I
M
E
-
Y
L
G
GG
S
-
A
L
-
D
L
L
R
A
G
P
F
D
E
-
F
Q
----------
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
R
-
N
T
--
F
-
V
G
T
P
F
W
-
M
A
P
E
V
I
------
Q
-
Q
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
-
P
----------------
P
---
N
S
D
M
------------
H
P
------
M
R
V
L
F
L
I
---
P
K
N
N
P
--------------------
P
T
-
L
V
G
--------
D
----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
104
PsiBlast_CBE
43.25
32%
-95
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[28-276]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
P
E
-
Q
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
92
PsiBlast_CBE
42.79
32%
-96
- C1 -
4ZJI
1
?
D:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
-----------
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
61
PsiBlast_CBE
42.65
33%
-87
- C1 -
4USE
1
?
B:
[9-280]
----------------------------------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
EI
V
G
E
-
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
-----
Y
-------------
W
I
M
I
E
-
F
C
P
--
G
-
G
A
-
V
D
A
I
M
L
E
L
D
R
-
G
L
----
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------
K
T
-
L
Q
K
----------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
L
N
------------
P
M
------
R
V
L
L
K
I
A
---
K
S
D
P
P
--------------------
T
L
-
L
T
P
--------
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
85
PsiBlast_CBE
42.29
31%
-90
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-289]
-----------------------------------------------
A
D
P
E
E
L
F
T
------
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
-----
L
K
--
G
S
------
K
L
W
I
I
M
E
-
Y
L
G
GG
S
-
A
L
-
D
L
L
R
A
G
P
F
D
E
-
F
Q
----------
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------------------
N
T
--
F
-
V
G
T
P
F
W
-
M
A
P
E
V
I
------
Q
-
Q
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
-
P
----------------
P
---
N
S
D
M
------------
H
P
------
M
R
V
L
F
L
I
---
P
K
N
N
P
--------------------
P
T
-
L
V
G
--------
D
----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
93
PsiBlast_CBE
42.27
32%
-90
- C1 -
4ZJI
1
?
C:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-------------
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
88
PsiBlast_CBE
38.65
32%
-95
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
--
N
L
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
---------
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
-----------
P
E
-
Q
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
-
R
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
89
PsiBlast_CBE
37.77
32%
-94
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[29-277]
---------------------------------------------------------------
K
-
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
--
N
L
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
-----
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
--
G
-
S
L
T
D
V
V
T
E
T
C
M
D
E
-
G
Q
----------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--------------
E
-
Q
S
K
-
R
S
--
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
---
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
----------------
Y
---
L
N
-
E
------------
N
P
------
L
R
A
L
Y
L
I
---
A
T
N
G
T
--------------------
P
E
-
L
Q
N
P-------
E
---
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T