@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0245: (2015-11-29 )
MIVDSHCHLIYFSDDEIPEVISRAEQNGVKILHNICVNADDVPKLLKIASSYNQVYSSIGIHPLDASVENGKCMHADELVELIKNQKVVSIGETGLDFYKSNNKSNQKKSFASHIEAARITGLPLVIHTRGVDSEVIDMLKSEMKNGPFNGVMHCFTSSKELAHQSIDLGLYISFSGIITFKNASLLRRIAQDVPRERVLVETDAPYLSPEPHRGKKNEPAMVKYVVDCLAELWSASPDKVAEVTTNNFFRLFTKLKLKEIL
Atome Classification :
(20 SA)
--.........-----------10--..----.-----------.----....20........30........40..----......50..-----.-----.-....60.....-..----------------.---70--.------------------.......---80...------.--.------.--..90........-----100-.-----..-..-...110......----.120---........130...-....140..-------------------------.-----------------------....-150.-......160......--.170.......180-.-...-...190.......200.....-----..-210-------------------.---------------------.---------------------------.----------------------------------------..---------------------..220.......230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
I
VDS
H
C
H
L
-----------
I
Y
--FS----D-----------D----
E
I
P
E
V
I
S
R
A
EQN
G
V
K
I
L
H
N
ICV
N
A
D
D
V
P
----
K
L
L
K
I
A
S
S
Y
N
-----
Q
-----
V
-
Y
S
SIGIHPLDA-SV----------------E---NG--K------------------CM
H
A
D
E
L
---
V
E
L
I
K------N--Q------
K
--
V
V
S
IGETG
L
D
FY-----KS--N-----NK-S
N
-
Q
K
K
S
F
A
S
H
I
E
A
A
----RIT----G
L
P
L
V
I
H
TRGV
D
S
E
-
V
I
D
M
L
K
S
E
M-------------------------K-----------------------NGP
F
-
N
G
V
M
-
H
C
FTS
S
K
E
L
A
HQSI
D
--
L
G
L
Y
I
S
F
S
G
I
I
T
FK-
N
-
A
S
L
-
L
R
R
I
A
Q
DVPR
E
R
V
L
V
ETDAPY-----LS-PEP-------------------H---------------------R---------------------------G----------------------------------------KK---------------------NE
P
A
M
V
K
Y
V
V
D
C
L
A
E
L
WSASPD
K
V
A
EVT
T
N
N
F
F
R
L
F
T
K
L
K
L
K
EIL
1
PsiBlast_PDB
97.71
39%
-100
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-254]
--
F
L
V
D
S
H
C
H
L
-----------
D
G
--
L
D
----
Y
-----------
E
SLHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
D
-----
N
-----
V
-
V
F
S
C
G
V
H
P
L
N
------------------------
Q
N
--
D
------------------
P
Y
D
V
E
D
L
---
R
R
L
A
A
------
E
--
E
------
G
--
V
V
A
L
G
E
T
G
L
D
Y
Y
-----
Y
T
P-
E
-----
T
K
-
V
R
-
Q
Q
E
S
F
I
H
H
I
Q
I
G
----
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
-
T
L
A
I
L
R
E
E
--------------------------
K
-----------------------
V
T
D
C
-
G
G
V
L
-
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
R
-
N
-
A
E
Q
-
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
-
P
V
P
-------------------
H
---------------------
R
---------------------------
G
----------------------------------------
K
E
---------------------
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
L
Q
S
21
PsiBlast_CBE
97.12
39%
-99
- C2 -
1YIX
2
YCFH_ECOLI
B:
[2-254]
--
F
L
V
D
S
H
C
H
L
-----------
D
G
--
L
D
----
Y
-----------
E
SLHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
D
-----
N
-----
V
-
V
F
S
C
G
V
H
P
L
N
------------------------
Q
N
--
D
------------------
P
Y
D
V
E
D
L
---
R
R
L
A
A
------
E
--
E
------
G
--
V
V
A
L
G
E
T
G
L
D
Y
Y
-----
Y
T
P-
E
-----
T
K
-
V
R
-
Q
Q
E
S
F
I
H
H
I
Q
I
G
----
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
-
T
L
A
I
L
R
E
E
--------------------------
K
-----------------------
V
T
D
C
-
G
G
V
L
-
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
R
-
N
-
A
E
Q
-
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
-
P
V
P
-------------------
H
---------------------
R
---------------------------
G
----------------------------------------
K
E
---------------------
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
L
Q
S
24
HHSearch
93.91
39%
-89
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-261]
--
F
L
V
D
S
H
C
H
L
-----------
D
G
--
L
D
YESL
H
-----------
K
----
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
----
H
M
R
D
L
V
G
E
R
D
-----
N
-----
V
-
V
F
S
C
G
V
H
P
L
N
Q
-
N
D
----------------
P
-------
Y
------------------
D
--
V
E
D
L
---
R
R
L
A
A
------
E
--
E
------
G
--
V
V
A
L
G
E
T
G
L
D
Y
Y
-----
Y
T
--
P
E----
T
K
-
V
R
-
Q
Q
E
S
F
I
H
H
I
Q
I
G
----
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
-
T
L
A
I
L
R
E
E
--------------------------
K
-----------------------
V
-
T
D
-
C
G
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
R
-
N
-
A
E
Q
-
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
-
P
V
P
-------------------
H
---------------------
R
---------------------------
G
----------------------------------------
K
E
---------------------
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
S
R
L
Q
S
3
PsiBlast_PDB
93.65
38%
-94
- C2 -
2GZX
2
?
A:
[2-253]
---
L
I
D
T
H
V
H
L
N----------
D
E
--
Q
Y
----
D
-----------
D
----
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
----
R
A
M
K
L
I
D
E
Y
D
-----
F
-----
L
-
Y
G
I
I
G
W
H
P
V
D
A
-
I
---------------------
D
F
--
T
------------------
E
E
H
L
E
W
I
---
E
S
L
A
Q
------
H
--
P
------
K
--
V
I
G
I
G
E
M
G
L
D
Y
H
-----
W
D
--
K
-----
S
P
-
A
D
V
Q
K
E
V
F
R
K
Q
I
A
L
A
----
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
-
C
I
D
I
L
L
E
E
H
-------------------------
A
-----------------------
E
-
E
V
-
G
G
I
M
-
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
K-
L
N
F
Y
I
S
L
G
G
P
V
T
F
K
-
N
-
A
K
Q
-
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
-
P
H
P
-------------------
Y
---------------------
R
---------------------------
G
----------------------------------------
K
R
---------------------
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
--------
25
HHSearch
92.23
38%
-94
- C2 -
2GZX
2
?
A:
[2-254]
---
L
I
D
T
H
V
H
L
-----------
N
D
--
E
Q
Y---
D
-----------
D
----
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
----
R
A
M
K
L
I
D
E
Y
D
-----
F
-----
L
-
Y
G
I
I
G
W
H
P
V
D
A
-
I
D
----------------
F
---
T
E
--
E
------------------
H
--
L
E
W
I
---
E
S
L
A
Q
------
H
--
P
------
K
--
V
I
G
I
G
E
M
G
L
D
Y
H
-----
W
D
--
K
S----
P
A
-
D
V
-
Q
K
E
V
F
R
K
Q
I
A
L
A
----
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
I
L
L
E
E
H
--------------------------
A
-----------------------
E
-
E
V
-
G
G
I
M
-
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
K-
L
N
F
Y
I
S
L
G
G
P
V
T
F
K
-
N
-
A
K
Q
-
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
-
P
H
P
-------------------
Y
---------------------
R
---------------------------
G
----------------------------------------
K
R
---------------------
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
--------
2
PsiBlast_PDB
92.11
37%
-93
- C2 -
1J6O
-
?
A:
[1-254]
----
V
D
T
H
A
H
L
-----------
H
F
--
H
Q
F---
D
-----------
D
----
D
R
N
A
V
I
S
S
F
E
E
N
N
I
E
F
V
V
N
V
G
V
N
L
E
D
S
K
----
K
S
L
D
L
S
K
T
S
D
-----
R
-----
I
-
F
C
S
V
G
V
H
P
H
D
A
K
E
V
----------------
P
---
E
D
--
F
------------------
I
E
H
---
L
---
E
K
F
A
K
------
D
--
E
------
K
--
V
V
A
I
G
E
T
G
L
D
F
F
-----
R
N
--
I
-----
S
P
-
A
E
V
Q
K
R
V
F
V
E
Q
I
E
L
A
----
G
K
L
----
N
L
P
L
V
V
H
I
R
D
A
Y
S
E
-
A
Y
E
I
L
R
T
E
S
-------------------------
L
-----------------------
P
E
K
--
R
G
V
I
-
H
A
F
S
S
D
Y
E
W
A
K
K
F
I
D
--
L
G
F
L
L
G
I
G
G
P
V
T
Y
P
-
K
-
N
E
A
-
L
R
E
V
V
K
R
V
G
L
E
Y
I
V
L
E
T
D
C
P
F
-----
L
P
-
P
Q
P
-------------------
F
---------------------
R
---------------------------
G
----------------------------------------
K
R
---------------------
N
E
P
K
Y
L
K
Y
V
V
E
T
I
S
Q
V
L
G
V
P
E
A
K
V
D
E
A
T
T
E
N
A
R
R
I
F
L
E
V
K
E
----
4
PsiBlast_PDB
89.96
29%
-95
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[5-256]
---
F
I
D
T
H
C
H
F
-----------
D
F
PP
F
S
----
G
-----------
D
----
E
-
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
----
R
V
L
A
L
A
E
N
Y
Q
-----
P
-----
L
-
Y
A
A
L
G
L
H
P
--
G
-
M
L
----------------
E
---
K
H
--
S
------------------
D
V
S
L
E
Q
L
---
Q
Q
A
L
E
------
R
--
R
PA----
K
--
V
V
A
V
G
E
I
G
L
D
L
F
-----
G
D
--
D
-----
P
Q
F
E
R
-
Q
Q
W
L
L
D
E
Q
L
K
L
A
----
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
-
L
A
M
H
L
K
R
H
--------------------------------------------------
D
L
P
R
-
T
G
V
V
-
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
Q
--
L
G
Y
K
I
G
V
G
G
T
I
T
Y
P
-
R
-
A
S
K
-
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
-
L
N
G
-------------------
F
---------------------
Q
---------------------------
G
----------------------------------------
Q
P
---------------------
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
------
29
HHSearch
88.29
29%
-87
- C2 -
2XIO
3
TATD1_HUMAN
A:
[2-293]
--
K
F
I
D
I
G
I
N
L
-----------
T
D
--
P
M
F---
R
GIYRGVQKHQ-
D
----
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
----
D
A
L
H
L
A
Q
T
N
G
-----
M
-----
F
-
F
S
T
V
G
C
H
P
T
R
C
-
G
E
----------------
F
---
E
K
N
N
P
------------------
D
L
Y
L
K
E
L
---
L
N
L
A
E
N
N
----
K
--
G
------
K
--
V
V
A
I
G
E
C
G
L
D
F
D
-----
R
L
--
Q
FC---
P
K
-
D
T
-
Q
L
K
Y
F
E
K
Q
F
E
L
S
----
E
Q
T
----
K
L
P
M
F
L
H
C
R
N
S
H
A
E
-
F
L
D
I
T
K
R
N
--------------------------
R
-----------------------
D
R
C
V
-
G
G
V
V
-
H
S
F
D
G
T
K
E
A
A
A
A
L
I
D
--
L
D
L
Y
I
G
F
N
G
C
S
L
K
T
----
E
A
-
N
L
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
G
-
V
K
S
T------------------
H
AGSKYIRTAFPTKKKWESGHC
L
---------------------------
K
----------------------------------------
D
R
---------------------
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
V
------
31
HHSearch
87.91
27%
-103
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[5-268]
--
G
L
V
D
C
H
C
H
L
-----------
S
A
--
P
D
F---
D
-----------
R
----
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
----
K
I
M
Q
L
S
E
R
Y
N
-----
G
-----
F
V
L
P
C
L
G
V
H
P
V
Q
---------------------RSV
T
L
--
K
------------------
D
--
L
D
V
A
---
L
P
I
I
E
N
Y
----
K
--
D
------
R
--
L
L
A
I
G
E
V
G
L
D
F
S
-----
P
R
--
F
AGT
G
E
Q
K
-
E
E
-
Q
R
Q
V
L
I
R
Q
I
Q
L
A
----
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
-
T
I
N
L
L
Q
E
Q
--------------------------
G
-------------------------
A
E
-
K
V
L
L
-
H
A
F
D
G
R
P
S
V
A
M
E
G
V
R
--
A
G
Y
F
F
S
I
P
P
S
I
I
R
S
----
G
Q
-
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
-
P
E
K
---------------------------------------------------------------------
Q
----------------------------------------
V
R
---------------------
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
R
H
L
L
--
22
HHSearch
86.30
27%
-91
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[4-259]
--
R
F
I
D
T
H
C
H
F
-----------
D
F
--
P
P
F---
S
-----------
G
----
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
----
R
V
L
A
L
A
E
N
Y
Q
-----
P
-----
L
-
Y
A
A
L
G
L
H
P
G
M
L
-
E
K
----------------
H
---
S
D
--
V
------------------
S
--
L
E
Q
L
---
Q
Q
A
L
E
------
R
RP
A
------
K
--
V
V
A
V
G
E
I
G
L
D
L
F
-----
G
D
--
D
P----
Q
F
-
E
R
-
Q
Q
W
L
L
D
E
Q
L
K
L
A
----
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
-
L
A
M
H
L
K
R
H
--------------------------
D
-------------------------
L
P
R
T
G
V
V
-
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
Q
--
L
G
Y
K
I
G
V
G
G
T
I
T
Y
P
-
R
-
A
S
K
-
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
-
L
N
G
-------------------
F
---------------------
Q
---------------------------
G
----------------------------------------
Q
P
---------------------
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
------
8
PsiBlast_PDB
85.71
29%
-83
- C2 -
2XIO
3
TATD1_HUMAN
A:
[27-290]
--------------------------------------------
D
----
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
----
D
A
L
H
L
A
Q
T
N
G
-----
M
-----
F
-
F
S
T
V
G
C
H
P
T
R
C
-
G
E
F
E
--------------
K
---
N
N
--
P
------------------
D
L
Y
L
K
E
L
---
L
N
L
A
E
------
N
--
N
------
K
GK
V
V
A
I
G
E
C
G
L
D
F
D
-----
R
L
--
Q
FC---
P
K
-
D
T
-
Q
L
K
Y
F
E
K
Q
F
E
L
S
----
E
Q
T
----
K
L
P
M
F
L
H
C
R
N
S
H
A
E
-
F
L
D
I
T
K
R
N
--------------------------
R
-----------------------
D
R
C
V
-
G
G
V
V
-
H
S
F
D
G
T
K
E
A
A
A
A
L
I
D
--
L
D
L
Y
I
G
F
N
G
C
S
L
K
T
-
E
-
A
N
L
---
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
G
V
K
S
T
-------------------
H
---------------------
A
---------------------------
G
----------------------------------------
S
K
YIRTAFPTKKKWESGHCLKDR
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
V
------
28
HHSearch
84.92
26%
-95
- C2 -
3RCM
3
?
A:
[2-268]
--
Q
L
I
D
I
G
V
N
L
-----------
T
N
--
S
S
F---
H
-----------
D
----
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
----
Q
A
L
E
L
C
Q
Q
L
D
ASG--
A
-----
H
L
F
A
T
A
G
V
H
P
H
D
A
-
K
A
----------------
W
---
D
T
--
D
------------------
S
--
E
R
Q
L
---
R
L
L
L
S
------
E
--
P
------
R
--
V
R
A
V
G
E
C
G
L
D
F
N
-----
R
D
--
F
S----
P
R
-
P
L
-
Q
E
K
A
L
E
A
Q
L
T
L
A
----
A
Q
L
----
R
L
P
V
F
L
H
E
R
D
A
S
E
R
-
L
L
A
I
L
K
D
Y
--------------------------
R
-----------------------
D
-
H
L
-
T
G
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
D
--
L
D
L
H
I
G
I
T
G
W
I
C
D
E
-
R
R
G
T
H
-
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
L
-
P
R
S
-------------------
L
---------------------
R
---------------------------
P
KPKS------------------------------------
G
R
---------------------
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
P
A
E
N
H
H
H
9
PsiBlast_PDB
84.83
26%
-99
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[6-267]
---
L
V
D
C
H
C
H
L
-----------
S
A
--
P
D
F---
D
-----------
R
----
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
----
K
I
M
Q
L
S
E
R
Y
N
-----
G
F----
V
-
L
P
C
L
G
V
H
P
V
Q
----------------------------
R
------------------
S
V
T
L
K
D
L
D
V
A
L
P
I
I
E
------
N
--
Y
------
K
DR
L
L
A
I
G
E
V
G
L
D
F
S
PRFAG
T
G
--
E
-----
Q
K
-
E
E
-
Q
R
Q
V
L
I
R
Q
I
Q
L
A
----
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
-
T
I
N
L
L
Q
E
Q
---------------------------------------------------
G
A
E
-
K
V
L
L
-
H
A
F
D
G
R
P
S
V
A
M
E
G
V
R
--
A
G
Y
F
F
S
I
P
P
S
I
I
R
S
-
G
-
Q
K
---
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
-
P
E
------------------------------------------
K
---------------------------
Q
----------------------------------------
V
R
---------------------
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
R
H
L
L
--
5
PsiBlast_PDB
84.68
28%
-92
- C2 -
4PE8
1
TATD_ECOLI
A:
[19-256]
----------------------------------------------------
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
S
-----
S
-----
C
-
W
S
T
A
G
V
H
P
H
D
S
-
S
Q
----------------
W
---
Q
A
--
A
------------------
T
E
E
A
--
I
---
I
E
L
A
A
------
Q
--
P
------
E
--
V
V
A
I
G
E
C
G
L
D
F
N
-----
R
N
F-
S
-----
T
P
-
E
E
-
Q
E
R
A
F
V
A
Q
L
R
I
A
----
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
-
F
M
T
L
L
E
P
W
L
-------------------------
D
-----------------------
K
L
P
--
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
-
R
-
R
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
-
P
K
P
-----------------------------------------
S
---------------------------
S
----------------------------------------
R
R
---------------------
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
-----
6
PsiBlast_PDB
84.33
28%
-95
- C2 -
4P5U
-
TATD_ECOLI
A:
[19-256]
----------------------------------------------------
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
S
-----
S
-----
C
-
W
S
T
A
G
V
H
P
H
D
S
-
S
Q
----------------
W
---
Q
A
--
A
------------------
T
E
E
A
--
I
---
I
E
L
A
A
------
Q
--
P
------
E
--
V
V
A
I
G
E
C
G
L
D
F
N
-----
R
N
F-
S
-----
T
P
-
E
E
-
Q
E
R
A
F
V
A
Q
L
R
I
A
----
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
-
F
M
T
L
L
E
P
W
L
-------------------------
D
-----------------------
K
L
P
--
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
-
R
-
R
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
-
P
K
P
-----------------------------------------
S
---------------------------
S
----------------------------------------
R
R
---------------------
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
L
E
---
26
HHSearch
83.50
27%
-91
* C2 *
1XWY
1
TATD_ECOLI
A:
[5-263]
---
M
F
D
I
G
V
N
L
-----------
T
S
--
S
Q
F---
A
-----------
K
----
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
S
-----
S
-----
C
-
W
S
T
A
G
V
H
P
H
D
S
-
S
Q
----------------
W
---
Q
A
--
A
------------------
T
--
E
E
A
I
---
I
E
L
A
A
------
Q
--
P
------
E
--
V
V
A
I
G
E
C
G
L
D
F
N
-----
R
N
--
F
S----
T
P
-
E
E
-
Q
E
R
A
F
V
A
Q
L
R
I
A
----
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
-
F
M
T
L
L
E
P
W
--------------------------
L
-----------------------
D
K
L
P
-
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
R
-
G
L
E
-
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
-
P
R
D
-------------------
L
---------------------
T
PKPS-----------------------
S
----------------------------------------
R
R
---------------------
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
-----
7
PsiBlast_PDB
83.05
28%
-95
- C2 -
1XWY
1
TATD_ECOLI
A:
[23-260]
----------------------------------------------------
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
----
Q
A
Q
K
L
A
R
Q
Y
S
-----
S
-----
C
-
W
S
T
A
G
V
H
P
H
D
S
-
S
Q
----------------
W
---
Q
A
--
A
------------------
T
E
E
A
--
I
---
I
E
L
A
A
------
Q
--
P
------
E
--
V
V
A
I
G
E
C
G
L
D
F
N
-----
R
N
F-
S
-----
T
P
-
E
E
-
Q
E
R
A
F
V
A
Q
L
R
I
A
----
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
-
F
M
T
L
L
E
P
W
L
-------------------------
D
-----------------------
K
L
P
--
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
-
R
-
R
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
-
P
K
P
-------------------
S
-------------------------------------------------
S
----------------------------------------
R
R
---------------------
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
F
-----
30
HHSearch
79.82
24%
-81
- C2 -
3IPW
1
?
A:
[27-323]
--
Q
F
I
D
I
G
A
N
L
-----------
T
D
--
D
N
----
Y
FGNYHGKHYHE
E
----
D
I
D
V
V
L
Q
R
A
E
R
N
G
L
S
H
I
I
I
T
S
G
C
L
N
D
F
K
----
K
A
I
E
I
I
N
K
Y
Q
-----
N
LTN
I
K
L
-
V
T
T
I
G
V
H
P
T
R
T
-
N
E
----------------
L
---
K
---
Q
------------------
E
G
Y
L
D
E
L
---
L
L
L
C
E
K
N
----
I
--
D
------
K
--
V
V
A
I
G
E
I
G
L
D
Y
E
-----
R
L
QF
S
-----
D
K
-
E
T
-
Q
L
S
G
Y
R
T
L
S
I
L
H
----
Q
K
Y
P---
Y
L
P
F
F
F
H
C
R
K
S
W
S
D
-
L
C
Q
L
N
K
E
L
--------------------------
G
-----------------------
Y
-
N
G
-
C
K
G
V
V
H
C
F
D
G
T
E
E
E
M
N
Q
I
L
N
--
E
G
W
D
I
G
V
T
G
N
S
L
Q
----
S
I
E
-
L
L
N
V
M
K
Q
I
P
I
E
R
L
H
I
E
T
D
C
P
Y
-----
C
G
-
I
K
K
TSAGFKYLKEKDFGVKVEK
Y
---------------------
Q
RNKYV----------------------
Q
----------------------------------------
R
R
---------------------
N
E
P
S
N
I
I
D
I
A
I
I
M
S
S
I
K
H
I
S
L
F
E
F
V
N
K
V
Y
S
N
S
M
N
M
Y
F
P
T
------
43
Fugue
77.66
22%
-85
- C2 -
3E2V
3
?
A:
[11-393]
P
L
K
Y
Y
D
I
G
L
N
L
TDPMFHGIYNG
K
Q
--
Y
H
----
P
-----------
A
----
D
Y
V
K
L
L
E
R
A
A
Q
R
H
V
K
N
A
L
V
T
G
S
S
I
A
E
S
Q
----
S
A
I
E
L
V
S
S
V
K
DLSPL
K
-----
L
-
Y
H
T
I
G
V
H
P
C
C
V
-
N
E
FAE
A
Y
N
E
S
L
Y
A
K
V
I
S
N
P
---
S
F
--
A
------------------
Q
G
K
L
K
E
L
---
Y
D
L
M
N
------
Q
--
Q
A
KPHDT
S
--
F
R
S
I
G
E
I
G
L
D
Y
D
-----
R
F
--
H
YS---
S
K
-
E
M
-
Q
K
V
F
F
E
E
Q
L
K
I
S
C
LN
D
K
L
S
----
S
Y
P
L
F
L
H
M
R
S
A
C
D
D
-
F
V
Q
I
L
E
R
F
V
-------------------------
V
G
F
T
D
EKDTFQLQKLSSSSG
F
Y
K
F
H
P
D
R
-
K
L
V
V
-
H
S
F
T
G
S
A
I
D
L
Q
K
L
L
N
--
L
S
P
N
I
F
I
G
V
N
G
C
S
L
-
R
-
T
E
E
-
N
L
A
V
V
K
Q
I
P
T
E
R
L
L
L
E
T
D
A
P
W
-----
C
E
-
I
K
R
-------------------
T
---------------------
H
---------------------------
A
S
F
Q
Y
L
A
K
Y
Q
E
VRDFEYPA
F
K
S
V
K
KNKLADKLNAE
E
L
Y
M
V
K
G
R
---------------------
N
E
P
C
N
M
E
Q
V
A
I
V
V
S
E
V
K
D
V
D
L
A
T
L
I
D
T
T
W
K
T
T
C
K
I
F
G
--------
33
HHSearch
77.48
22%
-93
- C2 -
3E2V
3
?
A:
[13-393]
--
K
Y
Y
D
I
G
L
N
L
-----------
T
D
--
P
M
----
F
HGIYNGKQYHP
A
----
D
Y
V
K
L
L
E
R
A
A
Q
R
H
V
K
N
A
L
V
T
G
S
S
I
A
E
S
Q
S
A
I
E
L
V
S
S
V
K
D
L
S
P
-----
L
K----
L
-
Y
H
T
I
G
V
H
P
C
C
V
-
N
E
----------------
F
---
A
----E
A
Y
N
E
S
L
Y
A
K
V
I
S
NP
S
F
A
Q
G
K
L
K
E
L
---
Y
D
L
M
N
Q
Q
A
KPH
D
--
T
------
S
--
F
R
S
I
G
E
I
G
L
D
Y
D
-----
R
F
--
H
YS---
S
K
-
E
M
-
Q
K
V
F
F
E
E
Q
L
K
I
S
----
C
L
N
D
K
L
S
S
Y
P
L
F
L
H
M
R
S
A
C
D
D
-
F
V
Q
I
L
E
R
F
V
V
G
F
T
D
EKDTFQLQKLSSSSG
F
Y
K
F
H
P
-------------------------
D
R
-
K
L
V
V
-
H
S
F
T
G
S
A
I
D
L
Q
K
L
L
N
L
S
P
N
I
F
I
G
V
N
G
C
S
L
R
T
----
E
E
-
N
L
A
V
V
K
Q
I
P
T
E
R
L
L
L
E
T
D
A
P
W
-----
C
E
-
I
K
R
THAS
F
Q
Y
L
A
K
Y
Q
-------
E
V--------------------
R
DFEYPA
F
K
S
V
K
KNKLADKLNAE
E
L
Y
M
V
K
----------------------------------------
G
R
---------------------
N
E
P
C
N
M
E
Q
V
A
I
V
V
S
E
V
K
D
V
D
L
A
T
L
I
D
T
T
W
K
T
T
C
K
I
F
G
--------