@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0276: (2015-11-29 )
MSLINPKVSAMFFDQIVTATDHNIAWEKIQNLLYNLYGEATYNSWLSSLKFVSSSNGEVLLSVPTRFIKEWITVHYMEKILLLWQNEDKSICSIDIQVTEEKNSSSSIISKNKEESVNNLGSPLDPRFTFDNFVVGKPNELAFTAAKRVAESIDPIPGSNPLFLYGGVGLGKTHLMHAIAWHIVNSPSAKRKVVYLSAEKFMYQYITALRSKDIMLFKEQFRSVDVLMVDDVQFISGKDSTQEEFFHTFNALIDQNKQLVISADRSPSDLDGVEERIKSRLGWGLVADINETTFELRLGILQAKVEQMNMYVPQDVLEFLARNIRSNIRELEGALNKVAHTSLIGRSMTVESASETLMDLLRSNHRSITIAEIQKKIAEFFNIKVTDMHSNRRLRSLVRPRQIAMYFAKKFTHKSLPDIGRSFGGRDHATVIHAVKQIENFIKTDSEFADEINQLRKMFK
Atome Classification :
(20 SA)
------------------------------------.........10........20........30........-40........50........60........70........80........90.....-----...100.......110-.......120.......130.......140.......150.......-160.......-----------170.......180..-----------------------------------------.....190-.......---------.200..-------.----..-----..210...----.....----.220.-.-.--.....230.......240.......250...---------..-..260.......-------------270.......---------280...-----....290.......300.......310.-..-----....320.......330.....-.-.340..-.-....-350.......360.......370......--..380.......390.......400...-------....-410.......420.......430.......440.----------......450.......460--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------MSLINP
K
V
S
A
M
F
F
D
Q
I
V
TATDHN
I
A
W
E
K
I
Q
N
L
L
Y
N
L
YGE-
A
T
Y
N
S
W
L
S
S
L
K
F
VSSSNG
E
V
L
L
SV
P
T
R
F
I
K
E
W
I
T
V
H
Y
M
E
K
I
L
L
L
WQNEDK
S
I
C
S
I
D
I
-----
Q
V
T
EEKNSS
S
S
I
I
SKN-
K
E
E
S
V
NNLGSPLDPRFTFDNFVVGKP
N
E
L
A
F
T
A
A
K
R
V
A
E
SIDPIPGS-N
P
L
F
L
YGGVG-----------L
G
K
T
H
L
M
H
A
I
A
W
H
IV-----------------------------------------NSPSAK
R
--
K
V
V
Y
L
S
A
---------
E
K
F
M
Y
Q
-------
Y
----
I
T
-----
A
LR--SK
D
----
I
M
L
F
K
----
E
Q-FR-S-V--
D
V
L
M
V
D
D
V
Q
FISGKD
S
T
Q
E
E
F
F
H
T
F
N
A
L
IDQ---------N
K
-
Q
L
V
I
SADRSPS
D
-------------
L
D
G
V
E
E
R
I
K
S
---------RLGW
G
L
-----
V
ADINE
T
T
F
E
L
R
L
G
I
L
Q
A
K
V
E
Q
M
NMYV
P
-
Q
D
-----
V
L
E
F
L
A
R
N
I
R
S
N
I
R
E
L
E
G
A
L
N
K
-
V
-
A
H
T
S
LI-G-RSM
T
-
V
E
S
A
S
E
T
L
M
D
L
L
RSNHR
S
I
T
I
A
-
E
I
Q
K
K
I
--
A
E
F
F
N
I
K
V
T
DMHS
N
R
R
L
R
S
LV
R
P
R
Q
I
A
M
-------
Y
F
A
K
-
K
FTHKS
L
P
D
I
G
R
S
FGGR
D
H
A
T
V
I
H
A
V
K
Q
I
E
N
F
I
K----------T
D
S
E
F
A
D
E
I
N
Q
L
R
K
MFK----
31
Fugue
94.27
35%
-116
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[2-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
--
L
G
S
L
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
K
-----------------------------------------
K
R
---
G
Y
--
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
--------
A
M
---
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
-----
N
M
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
-
K
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
-----------------
F
E
G
L
E
R
K
E
R
K
E
R
D
K
L
M
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
--
E
----------
K
K
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
D
K
IC
5
PsiBlast_PDB
90.95
34%
-110
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[4-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
G
Y
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
------
L
E
R
K
E
R
K
E
R
D
K
L
---------
M
-
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
41
HHSearch
90.76
35%
-104
- C2 -
1L8Q
2
DNAA_AQUAE
A:
[2-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
--
L
G
S
L
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
A
G
N
E
A
K
-----------------------------------------
K
R
---
G
Y
--
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
E
L
-
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
-
T
K
N
V
R
E
I
E
G
K
I
K
L
-
I
K
L
K
G
F
E
G
---
L
E
-
R
-
K
E
------------
R
K
E
R
D
K
L
M
-
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
25
PsiBlast_CBE
90.55
34%
-104
- C2 -
3R8F
4
DNAA_AQUAE
B:
[4-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
GY
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
-------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
24
PsiBlast_CBE
89.76
34%
-103
- C2 -
3R8F
4
DNAA_AQUAE
C:
[4-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
GY
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
-------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
23
PsiBlast_CBE
89.62
34%
-104
- C2 -
3R8F
3
DNAA_AQUAE
D:
[4-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
GY
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
-------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
4
PsiBlast_PDB
89.47
34%
-100
- C2 -
2HCB
3
DNAA_AQUAE
A:
[3-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
G
Y
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
R
--
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
--
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
3
PsiBlast_PDB
89.29
34%
-104
- C2 -
3R8F
4
DNAA_AQUAE
A:
[4-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
G
Y
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
-------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
27
PsiBlast_CBE
88.76
34%
-100
- C2 -
2HCB
3
DNAA_AQUAE
C:
[3-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
GY
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
---
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
26
PsiBlast_CBE
88.48
34%
-102
- C2 -
2HCB
2
DNAA_AQUAE
D:
[3-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
GY
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
R
K
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
28
PsiBlast_CBE
87.70
34%
-96
- C2 -
2HCB
3
DNAA_AQUAE
B:
[3-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
Y
T
L
E
N
F
I
V
G
E
G
N
R
L
A
Y
E
V
V
K
E
A
L
E
N
L
G
S
L
--
Y
-
N
P
I
F
I
Y
G
S
V
G
-----------
T
G
K
T
H
L
L
Q
A
-----
A
-----------------------------------------
G
N
E
A
K
K
R
G
Y
R
V
I
Y
S
S
A
---------
D
D
F
A
Q
A
-------
M
----
V
E
-----
H
L
K
--
K
G
T
----
I
N
E
F
R
----
N
M
-
Y
K
-
S
-
V
--
D
L
L
L
L
D
D
V
Q
F
L
S
G
K
E
R
T
Q
I
E
F
F
H
I
F
N
T
L
Y
L
L
---------
E
K
-
Q
I
I
L
A
S
D
R
H
P
Q
K
-------------
L
D
G
V
S
D
R
L
V
S
---------
R
F
E
G
G
I
-----
L
V
E
I
-
E
L
D
N
K
T
R
F
K
I
I
K
E
K
L
K
E
F
N
L
E
L
R
-
K
E
-----
V
I
D
Y
L
L
E
N
T
K
-
N
V
R
E
I
E
G
K
I
K
L
-
I
-
K
L
K
G
F
E
-
G
-
L
E
R
K
-
E
R
K
E
R
D
K
L
M
--------------
Q
I
V
E
F
V
--
A
N
Y
Y
A
V
K
V
E
D
I
L
S
D
K
-
N
K
R
T
S
E
A
R
K
I
A
M
-------
Y
L
C
R
-
K
V
C
S
A
S
L
I
E
I
A
R
A
F
K
--
D
H
T
T
V
I
H
A
I
R
S
V
E
E
E
K
K
------------
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
----
21
PsiBlast_CBE
82.52
35%
-108
- C2 -
2Z4R
2
DNAA_THEMA
C:
[96-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
----
P
G
R
Y
N
P
L
F
I
Y
G
G
V
G
-----------
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q----------------------------------------
N
E
P
D
L
R
----
V
M
Y
I
T
S
---------
E
K
F
L
N
D
-------
L
----
V
D
-----
S
M
K
--
E
G
K
----
L
N
E
F
R
----
E
K
-
Y
R
-
K
K
V
--
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
V
Q
T
E
L
F
H
T
F
N
E
L
H
D
S
---------
G
K
-
Q
I
V
I
C
S
D
R
E
P
Q
K
-------------
L
S
E
F
Q
D
R
L
V
S
---------
R
F
Q
M
G
L
-----
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
-
E
E
-----
V
L
N
F
V
A
E
N
V
D
D
N
L
R
R
L
R
G
A
I
I
K
L
L
-
V
Y
K
E
T
T
-
G
-
K
E
V
D
-
L
K
E
A
I
L
L
L
K
D
F
I
K
P
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.46
35%
-110
- C2 -
2Z4S
2
DNAA_THEMA
A:
[96-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
----
P
G
R
Y
N
P
L
F
I
Y
G
G
V
G
-----------
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
----------------------------------------
N
E
P
D
L
R
----
V
M
Y
I
T
S
---------
E
K
F
L
N
D
-------
L
----
V
D
-----
S
M
K
--
E
G
K
----
L
N
E
F
R
----
E
K
-
Y
R
-
K
K
V
--
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
V
Q
T
E
L
F
H
T
F
N
E
L
H
D
S
---------
G
K
-
Q
I
V
I
C
S
D
R
E
P
Q
K
-------------
L
S
E
F
Q
D
R
L
V
S
---------
R
F
Q
M
G
L
-----
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
-
E
E
-----
V
L
N
F
V
A
E
N
V
D
D
N
L
R
R
L
R
G
A
I
I
K
L
L
-
V
Y
K
E
T
T
-
G
-
K
E
V
D
-
L
K
E
A
I
L
L
L
K
D
F
I
K
P
--------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.37
35%
-107
- C2 -
2Z4R
2
DNAA_THEMA
A:
[96-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
----
P
G
R
Y
N
P
L
F
I
Y
G
G
V
G
-----------
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q
----------------------------------------
N
E
P
D
L
R
----
V
M
Y
I
T
S
---------
E
K
F
L
N
D
-------
L
----
V
D
-----
S
M
K
--
E
G
K
----
L
N
E
F
R
----
E
K
-
Y
R
-
K
K
V
--
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
V
Q
T
E
L
F
H
T
F
N
E
L
H
D
S
---------
G
K
-
Q
I
V
I
C
S
D
R
E
P
Q
K
-------------
L
S
E
F
Q
D
R
L
V
S
---------
R
F
Q
M
G
L
-----
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
-
E
E
-----
V
L
N
F
V
A
E
N
V
D
D
N
L
R
R
L
R
G
A
I
I
K
L
L
-
V
Y
K
E
T
T
-
G
-
K
E
V
D
-
L
K
E
A
I
L
L
L
K
D
F
I
K
P
--------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.21
35%
-107
- C2 -
2Z4R
2
DNAA_THEMA
B:
[96-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
----
P
G
R
Y
N
P
L
F
I
Y
G
G
V
G
-----------
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
Q----------------------------------------
N
E
P
D
L
R
----
V
M
Y
I
T
S
---------
E
K
F
L
N
D
-------
L
----
V
D
-----
S
M
K
--
E
G
K
----
L
N
E
F
R
----
E
K
-
Y
R
-
K
K
V
--
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
V
Q
T
E
L
F
H
T
F
N
E
L
H
D
S
---------
G
K
-
Q
I
V
I
C
S
D
R
E
P
Q
K
-------------
L
S
E
F
Q
D
R
L
V
S
---------
R
F
Q
M
G
L
-----
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
-
E
E
-----
V
L
N
F
V
A
E
N
V
D
D
N
L
R
R
L
R
G
A
I
I
K
L
L
-
V
Y
K
E
T
T
-
G
-
K
E
V
D
-
L
K
E
A
I
L
L
L
K
D
F
I
K
P
--------------------------------------------------------------------------------------------------------------------------
40
HHSearch
81.38
32%
-110
* C2 *
2Z4S
2
DNAA_THEMA
A:
[96-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
L
N
P
D
Y
T
F
E
N
F
V
V
G
P
G
N
S
F
A
Y
H
A
A
L
E
V
A
K
H
--
P
G
-
R
Y
-
N
P
L
F
I
Y
G
G
V
G
-----------
L
G
K
T
H
L
L
Q
S
I
G
N
Y
V
V
-----------------------------------------
Q
N
E
-
P
D
L
--
R
V
M
Y
I
T
S
---------
E
K
F
L
N
D
-------
L
----
V
D
-----
S
M
K
--
E
G
K
----
L
N
E
F
R
----
E
K
-
Y
R
K
K
-
V
--
D
I
L
L
I
D
D
V
Q
F
L
I
G
K
T
G
V
Q
T
E
L
F
H
T
F
N
E
L
H
D
S
---------
G
K
-
Q
I
V
I
C
S
D
R
E
P
Q
K
-------------
L
S
E
F
Q
D
R
L
V
S
---------
R
F
Q
M
G
L
-----
V
A
K
L
E
P
P
D
E
E
T
R
K
S
I
A
R
K
M
L
E
I
E
H
G
E
L
P
-
E
E
-----
V
L
N
F
V
A
E
N
V
D
D
N
L
R
R
L
R
G
A
I
I
K
-
L
L
V
Y
K
E
T
T
-
G
-
K
E
V
D
-
L
K
E
A
I
L
L
L
K
D
F
I
K
P
--------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.53
25%
-79
- C2 -
3SC3
2
?
A:
[14-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
A
A
G
N
D
E
L
I
G
A
L
K
S
A
A
S
G
----
D
G
V
-
Q
A
I
Y
L
W
G
P
V
K
-----------
S
G
R
T
H
L
I
H
A
A
C
---
A
-----------------------------------------
R
A
N
E
L
E
R
--
R
S
F
Y
I
P
L
---------
G
-----------------
I
H
-----
A
S
I
--
S
T
A
----
L
L
E
G
L
----
E
Q
-
F
-------
D
L
I
C
I
D
D
V
D
A
V
A
G
H
P
L
W
E
E
A
I
F
D
L
Y
N
R
V
A
E
Q
---------
K
R
G
S
L
I
V
S
A
S
A
S
P
M
E
-------------
A
G
F
V
L
P
D
L
V
S
---------
R
M
H
W
G
L
-----
T
Y
Q
L
Q
P
M
M
D
D
E
K
L
A
A
L
Q
R
R
A
A
M
R
G
L
Q
L
P
-
E
D
-----
V
G
R
F
L
L
N
R
M
A
R
D
L
R
T
L
F
D
V
L
D
R
-
L
-
D
K
A
S
M
V
H
Q
-
R
K
L
T
-
I
P
F
V
K
E
M
L
R
L
------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
55.89
17%
-76
- C2 -
3PFI
1
?
A:
[27-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
D
G
Y
I
G
Q
E
S
I
K
K
N
L
N
V
F
I
A
A
A
K
K
--
R
N
E
C
L
-
D
H
I
L
F
S
G
P
A
G
-----------
L
G
K
T
T
L
A
N
I
I
S
Y
E
M
S
-----------------------------------------
A
--------
N
I
K
T
T
A
A
---------
P
M
I
E
K
-------------------------
S
G
D
----
L
A
A
I
L
----
T
N
-
L
S
-
E
-
G
--
D
I
L
F
I
D
E
I
H
R
L
S
P
A
--
I
E
E
V
L
Y
P
A
M
E
D
Y
R
L
-A
Q
T
I
K
I
D
L
P
K
F
-
T
L
I
G
A
T
T
R
A
-----------------
G
M
L
S
N
P
L
R
D
---------
R
F
G
M
-------
Q
F
R
L
E
F
Y
K
D
S
E
L
A
L
I
L
Q
K
A
A
L
K
L
N
K
T
C
E
-
E
K
-----
A
A
L
E
I
A
K
R
S
R
S
T
P
R
I
A
L
R
L
L
K
R
-
V
R
D
F
A
D
V
N
-
D
E
E
I
I
T
-
E
K
R
A
N
E
A
L
N
S
L
------------------------
G
V
N
E
L
G
F
D
A
--------
M
D
L
R
Y
L
E
-------
L
L
T
A
A
K
Q
K
P
I
G
L
A
S
I
A
A
A
L
S
-
E
D
E
N
T
I
E
D
V
I
E
P
Y
L
L
A
N
G
----------
Y
I
E
R
T
A
K
G
R
I
A
S
A
K
S
Y
S
----
38
Fugue
49.74
15%
-43
- C1 -
4UZY
2
?
A:
[9-650]
QQPA
R
P
I
A
EGQ
Y
T
Q
T
I
Y
T
L
I
K
E
QK
F
A
E
A
I
Q
H
L
Q
Y
Q
L
Q
N
V
P
E
S
R
A
A
L
S
L
L
G
Y
C
Y
Y
Y
T
G
Q
Y
D
M
A
S
Q
M
Y
E
Q
L
V
T
L
Y
P
S
N
E
D
Y
K
L
Y
Y
A
Q
S
L
Y
K
G
G
M
Y
P
E
A
S
K
A
V
V
K
--
V
E
G
H
Q
K
A
V
T
T
L
L
V
A
C
S
Y
E
Q
D
D
L
T
G
C
R
R
Q
L
D
K
CAP
E
D
P
D
T
M
V
N
T
G
C
I
M
F
K
E
G
K
F
E
A
A
R
Q
K
F
N
D
Y
Q
P
E
L
L
Y
N
I
A
L
C
Y
Y
K
T
K
Q
F
G
P
A
L
K
H
L
A
E
I
I
E
K
A
V
R
E
-
H
P
E
L
S
V
G
S
D
G
MEVRSVGNS
Q
T
L
K
E
T
A
L
I
E
A
F
N
L
K
A
A
I
E
Y
T
M
KN
V
E
A
A
K
E
A
L
T
D
MPPRAEEELD
P
V
T
L
H
N
S
A
L
I
N
M
DS
D
P
T
G
G
F
K
--
K
L
N
F
L
L
Q
S
PPFPPE
T
F
A
N
L
L
L
L
-------
Y
----
C
K
PSHGF
Y
D
L
--
A
A
D
----
V
L
A
E
N
----
P
Q
-
Y
A
-
G
-
K
LL
S
P
D
L
Y
D
Y
L
Q
A
A
I
G
R
Y
K
S
P
E
E
A
F
R
R
F
D
E
L
A
T
R
---------
H
V
-
E
Q
L
R
R
L
T
K
Q
I
Q
D
A
R
I
A
RD
N
D
A
I
K
R
A
I
N
E
Y
D
E
A
L
E
A
Y
I
P
G
L
M
A
M
A
S
I
Y
W
D
M
EL
Y
S
N
V
E
K
I
F
R
Q
S
A
E
F
C
S
E
H
E
V
W
K
L
N
V
A
H
T
F
F
M
-
Q
D
NH
Y
K
E
A
I
R
Y
Y
E
P
V
V
K
K
N
A
D
N
L
L
G
V
T
A
I
-
V
-
L
A
N
L
C
V
-
S
-
Y
I
M
T
S
Q
N
E
E
A
E
E
L
M
R
K
V
E
K
E
E
E
R
S
S
M
Q
-
D
P
D
K
P
C
F
H
L
C
I
I
N
L
V
I
G
T
L
Y
C
A
K
G
N
Y
E
F
G
V
S
R
I
I
K
S
L
EE
T
D
T
W
Y
Y
A
K
-
R
C
F
L
A
L
I
E
N
L
A
K
H
M
I
V
L
K
D
S
S
F
T
E
I
M
A
F
L
N
E
A
E
K
H
G
K
D
I
R
V
V
F
N
Q
S
R
T
I
A
S
E
A
R
M
L
K
K
M
F
L
K
L
R-
47
HHSearch
49.69
15%
-93
- C2 -
1SXJ
3
RFC5_YEAST
E:
[12-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
A
L
S
H
N
---
E
E
L
T
N
F
L
K
S
L
S
D
Q
---
P
R
D
L
-
P
H
L
L
L
Y
G
P
N
G
-----------
T
G
K
K
T
R
C
M
A
L
L
E
S
I
F
-----------------------------------------
G
P
---
G
V
--
Y
R
--------------------NVVSSPY
H
L
E
I
T
P
S
--------ND
R
I
V
I
Q
E
L
L
K
E
V
A
QMEQ------
R
-
Y
--
K
C
V
I
I
N
E
A
N
S
L
T
K
D
--
A
Q
A
A
L
R
R
T
M
E
K
Y
S
K
----------
N
I
-
R
L
I
M
V
C
D
S
M
-----------------
S
P
I
I
A
P
I
K
S
---------
Q
C
L
--------
L
I
R
C
P
A
P
S
D
S
E
I
S
T
I
L
S
D
V
V
T
N
E
R
I
Q
L
E
T
K
D
-----
I
L
K
R
I
A
Q
A
S
N
G
N
L
R
V
S
L
L
M
L
E
S
-
M
A
L
N
N
E
L
A
-
L
-
K
S
S
S
-
P
I
I
K
P
D
W
I
I
V
I
H
K
L
T
R
K
I
V
K
E
R
-
S
V
N
S
L
I
--
E
C
R
A
V
L
Y
D
L
L
A
H
C
I
P
A
N
I
I
L
K
E
L
T
F
S
L
L
-------
D
V
E
T
-
L
N
T
T
N
K
S
S
I
I
E
Y
S
S
V
F
D
E
R
L
S
L
G
N
K
A
I
F
H
L
E
G
F
I
----------
A
K
V
M
C
C
L
D
-------------