@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0403: (2015-12-01 )
MNFKSVVLCILDGWGNGIGDSKYNAISNANPPCWQYISSNYPRCSLSACGTDVGLPDGQIGNSEVGHMNICSGRVVMQSLQRIDREIKTIENNKNLRSFISDLKDKNGVCHIMGLVSDGGVHSHQKHISTLANKISQHEIKVVIHAFLDGRDTLPNSGKKCVQEFEENIKGNDIRIATVSGRYYAMDRDNRWERTIETYEAIAFARATCHNNVMSLIDNNYQNNITDEFIRPTVIGDYKGIELKDGVLLANFRADRMIQLASILLGKTGYTEVAKFSSILSMMKYKEDLQIPCLFPPAFFTNTLGEIIADNKLRQLRIAETEKYAHVTFFFNCGKEEPFSNEERILIPSPKVETYDLQPEMSAFELTEKLVGKIRSQEFTLIVANYANPDMVGHTGNMEAAKKAVLAVDDCLAKVLNTVKEINDAVLIVTADHGNVECMFDEKNNTPHTAHTLNKVPFIIYPNSCNNLKLKDGRLSDIAPTILQLLGIKKPDEMTGSSLIV
Atome Classification :
(20 SA)
.........10........20..-......30...--.....40...-.....--50.....-...-60........70........80........--90--....--....100.......110.......120......-.130.......-140-........150.......160.......170---.-.-.---.-..---...180...-....-.-190.......200.......210.......220.--.--.....230.....-----..----240---.........250..--------.....260..----....-----.270-----.--.------......-------280.......290..--.......300.......310.......320.......330.......340......--...350.......360.......370...--.--...380.......390-....----------------------------------------------------------....400.......410.......420---.......430.......440.-----------..---------.---------.--....450.......460------------......-----..470.-.--.-.....480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNF
K
S
V
V
L
C
I
LDGWGNGIGDSKY-NAISNANP
P
C
W
--
Q
Y
I
SSNYP
R
C
-SLSAC--GTDVGLP-DGQ-IGNSEVG
H
M
NIC
S
G
R
V
V
M
Q
S
L
Q
R
I
D
R
E
I
K
T
--IE--N
N
K
N
--
L
R
S
F
I
S
D
L
KDKNG
V
C
H
I
M
G
L
VSDGGV
H
S
H
Q
K
H
I
-
S
T
L
A
N
K
I
S
Q
H
E
-
I
-
K
-
V
V
I
H
A
FLDGRDTLPNS
G
K
K
C
V
Q
E
F
E
E
NIK-----G-N-
D
---
I
-
R
I
---
A
T
VS
G
-
R
Y
Y
-
A
MDR-D-N
R
W
E
R
T
I
E
T
Y
E
A
I
A
F
A
R
A
T
C
H
N
N
V
M
S
L
I
DNNYQN--N--I
T
D
E
FIRP
T
V
IGD-----YK----G-----
I
E
LKD
G
V
L
L
ANFR
A
--------
D
R
M
I
Q
L
A
S
I
L
----LGKT-----
G
Y
-
T
-----
E
--
V
------
A
K
F
S
S
I
-------
L
S
M
M
K
Y
K
E
DLQ--IP--CLF
P
P
A
F
F
T
N
T
L
G
E
I
I
ADNK
L
R
Q
L
R
IAETE
K
Y
A
H
V
T
F
F
F
NCGKEEPFS--NEE
R
I
L
--IPSPKV
E
T
Y
DLQPE
M
S
A
F
E
L
T
E
K
L
V
G
K
IR--S--Q
E
F
T
L
I
V
ANYANPD-M-VGHT----------------------------------------------------------G
N
M
E
A
A
K
K
A
V
L
A
V
D
D
C
L
A
K
V
L
N
T
V
K
EI---ND
A
V
L
I
V
T
ADHG
N
V
E
C
M
F--D-----------EK---------N---------N--TPHTAHTLNKV
P
F
I
I
Y-------------PNSCNN-----LKLK-D-G--R-L
S
D
I
A
P
T
I
L
Q
L
LGIKKPDEMTGSSLIV
42
Fugue
95.58
43%
-85
- C2 -
1EJJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
-
D
E
T
Y
G
-
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
GE
F
D
--
R
N
E
T
--
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
-
V
K
R
-
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
Y
G
-
V
---
G
-
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
FREFD
R
G
-
P
-----
K
--
H
------
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
---
G
-
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--
T
-----------
P
D
---------
G
---------
K
---
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
-------------
K
K
--
G
I
-----
K
L
R
D
-
G
-
G
--
I
-
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
9
PsiBlast_PDB
95.28
42%
-91
- C2 -
4QAX
3
?
A:
[11-511]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
--
N
A
V
K
L
A
N
K
P
N
F
--
D
R
Y
Y
N
K
Y
P
T
T
-
Q
I
E
A
S
--
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
--
G
D
FF
E
N
D
V
--
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
-
F
A
L
L
E
L
A
K
K
Q
G
-
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
--
A
K
-----
F
-
N
-
E
---
L
-
G
I
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
--------
D
R
A
A
Q
L
S
E
I
F
----
A
N
R
A
FE---
G
F
K
V
-----
E
--
Q
------
V
K
D
L
F
Y
-------
A
T
F
T
K
Y
N
D
N
I
D
--
A
A
--
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
--
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
----
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
--
T
-----------
D
----------
D
---------
D
--
Q
P
M
T
T
H
T
T
N
P
V
P
V
I
V
----------------
T
K
E
G
-----
V
T
L
R
-
E
T
G
--
R
-
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
22
HHSearch
95.04
43%
-85
- C2 -
1O98
9
GPMI_GEOSE
A:
[2-509]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
-
Y
G
-
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
GE
F
D
--
R
N
E
T
--
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
V
K
-
R
-
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
Y
G
-
V
---
G
-
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
GRPV
A
T----
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
FR---
E
F
-
D
R----
G
PK
H
------
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--
T
-----------
P
D
-------------------
G
--
K
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
-------------
K
K
G
I
K
-------
L
R
D
-
G
-
G
--
I
-
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
3
PsiBlast_PDB
94.98
43%
-88
- C2 -
1O98
9
GPMI_GEOSE
A:
[2-510]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
--
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
--
G
E
--
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
-
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
-
Y
-
G
---
V
G
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
------
F
-
R
-----
E
--
F
DRGPKH
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--------------
T
P
---------
D
---------
G
--
K
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
----------------
T
K
K
G
-----
I
K
L
R
-
D
-
G
--
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
6
PsiBlast_PDB
94.95
42%
-91
- C2 -
4MY4
2
?
A:
[11-511]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
--
N
A
V
K
L
A
N
K
P
N
F
--
D
R
Y
Y
N
K
Y
P
T
T
-
Q
I
E
A
S
--
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
--
G
D
FF
E
N
D
V
--
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
-
F
A
L
L
E
L
A
K
K
Q
G
-
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
--
A
K
-----
F
-
N
-
E
---
L
-
G
I
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
--------
D
R
A
A
Q
L
S
E
I
F
----
A
N
R
A
FE---
G
F
K
V
-----
E
--
Q
------
V
K
D
L
F
Y
-------
A
T
F
T
K
Y
N
D
N
I
D
--
A
A
--
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
--
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
----
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
--
T
-----------
D
----------
D
---------
D
--
Q
P
M
T
T
H
T
T
N
P
V
P
V
I
V
----------------
T
K
E
G
-----
V
T
L
R
-
E
T
G
--
R
-
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
7
PsiBlast_PDB
94.88
42%
-91
- C2 -
4NWJ
3
?
A:
[10-511]
-
A
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
--
N
A
V
K
L
A
N
K
P
N
F
--
D
R
Y
Y
N
K
Y
P
T
T
-
Q
I
E
A
S
--
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
--
G
D
FF
E
N
D
V
--
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
-
F
A
L
L
E
L
A
K
K
Q
G
-
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
--
A
K
-----
F
-
N
-
E
---
L
-
G
I
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
--------
D
R
A
A
Q
L
S
E
I
F
----
A
N
R
A
FE---
G
F
K
V
-----
E
--
Q
------
V
K
D
L
F
Y
-------
A
T
F
T
K
Y
N
D
N
I
D
--
A
A
--
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
--
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
----
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
--
T
-----------
D
----------
D
---------
D
--
Q
P
M
T
T
H
T
T
N
P
V
P
V
I
V
----------------
T
K
E
G
-----
V
T
L
R
-
E
T
G
--
R
-
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
5
PsiBlast_PDB
94.87
43%
-93
- C2 -
2IFY
2
GPMI_BACAN
A:
[2-507]
---
K
P
T
A
L
I
I
L
D
G
F
G
--
L
R
E
E
T
Y
G
N
A
V
A
Q
A
K
K
P
N
F
--
D
G
Y
W
N
K
F
P
H
T
-
T
L
T
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
R
E
--
G
E
--
F
D
K
N
E
T
F
Q
S
A
I
K
S
V
K
E
K
G
T
A
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
M
N
H
M
-
F
A
L
L
R
L
A
A
K
E
G
-
V
E
K
-
V
Y
I
H
A
F
L
D
G
R
D
V
G
P
K
T
A
Q
S
Y
I
D
A
T
N
E
V
I
K
-----
E
-
T
-
G
---
V
G
Q
F
---
A
T
I
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
C
Y
R
A
M
V
N
G
E
G
P
T
Y
K
S
A
E
E
C
V
E
D
S
Y
A
N
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
N
EDNTP
V
A
----
T
-----
I
N
D
D
D
A
V
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
A
R
V
F
----
T
N
G
D
-----
F
R
-
E
FDRGE
K
--
V
------
P
H
I
P
E
F
-------
V
C
M
T
H
F
S
E
T
V
D
--
G
Y
--
V
A
F
K
P
M
N
L
D
N
T
L
G
E
V
V
A
Q
A
G
L
K
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
F
S
G
G
R
E
A
E
F
P
--
G
E
E
R
I
L
--
I
N
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
I
Y
E
V
T
D
A
L
V
N
E
I
E
--
N
--
D
K
H
D
V
I
I
L
N
F
A
N
C
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
M
M
E
P
T
I
K
A
V
E
A
T
D
E
C
L
G
K
V
V
E
A
I
L
-
A
---
K
D
G
V
A
L
I
T
A
D
H
G
N
A
D
E
E
L
--
T
-----------
S
E
---------
G
---------
E
---
P
M
T
A
H
T
T
N
P
V
P
F
I
V
----------------
T
K
N
D
-----
V
E
L
R
E
D
-
G
--
I
-
L
G
D
I
A
P
T
M
L
T
L
L
G
V
E
Q
P
K
E
M
T
G
K
T
I
I
K
8
PsiBlast_PDB
94.64
42%
-92
- C2 -
4NWX
4
?
A:
[11-511]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
--
N
A
V
K
L
A
N
K
P
N
F
--
D
R
Y
Y
N
K
Y
P
T
T
-
Q
I
E
A
S
--
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
--
G
D
FF
E
N
D
V
--
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
-
F
A
L
L
E
L
A
K
K
Q
G
-
V
E
K
-
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
--
A
K
-----
F
-
N
-
E
---
L
-
G
I
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
--------
D
R
A
A
Q
L
S
E
I
F
----
A
N
R
A
FE---
G
F
K
V
-----
E
--
Q
------
V
K
D
L
F
Y
-------
A
T
F
T
K
Y
N
D
N
I
D
--
A
A
--
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
--
I
D
S
P
K
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
--
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
----
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
--
T
-----------
D
----------
D
---------
D
--
Q
P
M
T
T
H
T
T
N
P
V
P
V
I
V
----------------
T
K
E
G
-----
V
T
L
R
-
E
T
G
--
R
-
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
2
PsiBlast_PDB
94.60
43%
-87
- C2 -
1EQJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
--
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
--
G
E
--
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
-
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
-
Y
-
G
---
V
G
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
------
F
-
R
-----
E
--
F
DRGPKH
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--------------
T
P
---------
D
---------
G
--
K
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
----------------
T
K
K
G
-----
I
K
L
R
-
D
-
G
--
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
1
PsiBlast_PDB
94.38
43%
-88
- C2 -
1EJJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
--
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
--
G
E
--
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
-
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
-
Y
-
G
---
V
G
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
------
F
-
R
-----
E
--
F
DRGPKH
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--------------
T
P
---------
D
---------
G
--
K
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
----------------
T
K
K
G
-----
I
K
L
R
-
D
-
G
--
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
4
PsiBlast_PDB
94.27
43%
-89
- C2 -
1O99
8
GPMI_GEOSE
A:
[2-510]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
--
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
--
D
R
Y
W
N
E
Y
P
H
T
-
T
L
K
A
C
--
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
A
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
--
G
E
--
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
-
Y
A
L
L
R
L
A
A
K
E
G
-
V
-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
E
K
I
K
-----
E
-
Y
-
G
---
V
G
E
I
---
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
-----
E
D
----
G
RPV
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
--------
D
R
A
I
Q
I
S
N
T
F
----
T
N
E
D
------
F
-
R
-----
E
--
F
DRGPKH
P
K
H
L
F
F
-------
V
C
L
T
H
F
S
E
T
V
A
--
G
Y
--
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
--
I
N
S
P
K
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
--
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
-
V
G
H
S
----------------------------------------------------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
--------------
T
P
---------
D
---------
G
--
K
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
----------------
T
K
K
G
-----
I
K
L
R
-
D
-
G
--
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
12
PsiBlast_PDB
88.07
30%
-84
- C2 -
3IGZ
4
?
B:
[15-551]
---
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
-
Y
-
D
A
V
H
M
A
S
T
P
F
M
DA
H
R
R
D
N
R
H
F
R
C
--
V
R
A
H
--
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
GE
I
Y
--
T
G
E
G
--
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
I
Y
S
I
I
E
H
A
V
K
D
G
A
-
K
-
R
-
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
A
V
L
A
KVRQN
G
-
C
-
D
---
A
-
A
I
---
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
D
A
R
H
F
H
S
A
K
E
A
I
T
T
F
R
E
E
--
D
PK
V
T
D
Q
Y
Y
P
P
F
I
V
V
D
-----
E
Q
----
D
KPLGT
I
E
D
G
D
A
V
L
C
V
N
F
R
G
--------
D
R
V
I
E
M
T
R
A
F
EDED
F
N
K
F
-----
D
R
-
V
-----
R
--
V
------
P
K
V
R
-
Y
-------
A
G
M
M
R
Y
D
G
D
L
G
--
I
P
NN
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
--
E
K
H
E
T
F
KE
V
P
S
D
R
V
Q
-
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
--
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
-
V
G
H
T
----------------------------------------------------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
V
---
N
-
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
QR
D
-----------
K
K
GKPMKDGNG
N
---------
V
--
L
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
GAGLD--------
P
R
V
A
M
R
-----
T
D
L
P
-
A
-
A
--
G
-
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
Y
E
P
S
L
I
Y
V
11
PsiBlast_PDB
87.88
30%
-85
- C2 -
3IGY
4
?
B:
[15-551]
---
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
-
Y
-
D
A
V
H
M
A
S
T
P
F
M
DA
H
R
R
D
N
R
H
F
R
C
--
V
R
A
H
--
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
GE
I
Y
--
T
G
E
G
--
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
I
Y
S
I
I
E
H
A
V
K
D
G
A
-
K
-
R
-
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
A
V
L
A
KVRQN
G
-
C
-
D
---
A
-
A
I
---
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
D
A
R
H
F
H
S
A
K
E
A
I
T
T
F
R
E
E
--
D
PK
V
T
D
Q
Y
Y
P
P
F
I
V
V
D
-----
E
Q
----
D
KPLGT
I
E
D
G
D
A
V
L
C
V
N
F
R
G
--------
D
R
V
I
E
M
T
R
A
F
EDED
F
N
K
F
-----
D
R
-
V
-----
R
--
V
------
P
K
V
R
-
Y
-------
A
G
M
M
R
Y
D
G
D
L
G
--
I
P
NN
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
--
E
K
H
E
T
F
KE
V
P
S
D
R
V
Q
-
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
--
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
-
V
G
H
T
----------------------------------------------------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
V
---
N
-
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
QR
D
-----------
K
K
GKPMKDGNG
N
---------
V
--
L
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
GAGLD--------
P
R
V
A
M
R
-----
T
D
L
P
-
A
-
A
--
G
-
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
Y
E
P
S
L
I
Y
V
23
HHSearch
87.16
31%
-82
* C2 *
3IGZ
4
?
B:
[12-551]
L
P
R
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
-
D
Y
-
D
A
V
H
M
A
S
T
P
F
M
--
D
A
H
R
R
D
N
R
H
F
R
C
V
R
A
H
--
G
T
A
V
G
L
P
-
T
D
A
D
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
GE
I
Y
--
T
G
E
G
--
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
I
-
Y
S
I
I
E
H
A
V
K
D
G
A
K
-
R
-
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
A
V
L
A
-----
K
V
R
Q
N
GCD
A
-
A
I
---
A
S
G
G
G
R
M
F
V
-
T
M
D
R
-
Y
D
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
D
A
R
H
F
H
S
A
K
E
A
I
T
T
F
R
E
E
DP
K
--
V
T
D
Q
Y
Y
P
P
F
I
V
V
D
-----
E
Q
DKPL
G
T----
I
E
D
G
D
A
V
L
C
V
N
F
R
G
--------
D
R
V
I
E
M
T
R
A
F
----
E
D
E
D
FN---
K
F
-
D
R----
V
--
R
------
V
P
K
V
R
Y
-------
A
G
M
M
R
Y
D
G
D
L
G
IP
N
N
--
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
EK
H
E
T
F
K
E
--
V
P
S
D
R
V
-
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
--
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
-
V
G
H
T
----------------------------------------------------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
--
Q
-----------
R
D
---------
K
KGKPMKDGN
G
NV
L
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
-------------
G
A
G
L
D
P
RVAMR
T
D
L
P
-
A
-
A
--
G
-
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
Y
E
P
S
L
I
Y
V
10
PsiBlast_PDB
86.52
31%
-89
- C2 -
3NVL
3
?
A:
[34-562]
---
R
K
L
V
L
V
V
L
D
G
V
G
I
G
P
R
D
-
E
Y
-
D
A
V
H
V
A
K
T
P
L
M
--
D
A
L
F
-
N
D
P
K
H
-
F
R
S
I
C
AH
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
V
L
Q
G
A
S
L
V
D
D
A
L
E
S
--
G
E
IF
T
S
E
G
--
Y
R
Y
L
H
G
A
F
S
Q
P
G
R
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
V
Y
Q
I
L
K
H
A
G
A
N
G
A
-
K
-
R
-
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
K
T
S
F
K
F
T
D
E
L
E
E
V
L
A
K
L
R
E
G
G
-
C
-
D
---
A
-
R
I
---
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
E
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
E
G
R
A
F
K
S
A
R
E
A
L
T
K
F
R
E
E
D
A
N
--
I
S
D
Q
Y
Y
P
P
F
V
I
A
G
-----
D
D
----
G
RPIGT
I
E
D
G
D
A
V
L
C
F
N
F
R
G
--------
D
R
V
I
E
M
S
R
A
F
----
E
E
E
---------------
E
--
F
------
D
K
F
N
R
V
RLPKVR
Y
A
G
M
M
R
Y
D
G
D
L
G
--
I
P
NN
F
L
V
P
P
P
K
L
T
R
T
S
E
E
Y
L
I
G
S
G
C
N
I
F
A
L
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
L
S
--
E
E
R
E
T
F
C
E
I
P
S
D
R
V
Q
-
F
N
Q
K
P
L
M
K
S
K
E
I
T
D
A
A
V
D
A
I
K
--
S
--
G
K
Y
D
M
I
R
I
N
Y
P
N
G
D
-
M
-
V
G
H
T
----------------------------------------------------------
G
D
L
K
A
T
I
T
S
L
E
A
V
D
Q
S
L
Q
R
L
K
E
A
V
D
S
V
---
N
-
G
V
F
L
I
T
A
D
H
G
N
S
D
D
M
V
--
Q
R
D
KKG
K
P
V
R
D
A
E
G
---------
N
---------
L
--
M
P
L
T
S
H
T
L
A
P
V
P
V
F
I
G
G
AGLD--------
P
R
V
Q
M
R
-----
T
D
L
P
-
R
-
A
--
G
-
L
A
N
V
T
A
T
F
I
N
L
M
G
F
E
A
P
S
D
Y
E
P
S
L
I
E
V
21
PsiBlast_CBE
85.24
31%
-90
- C2 -
3NVL
3
?
B:
[34-562]
---
R
K
L
V
L
V
V
L
D
G
V
G
I
G
P
R
D
-
E
Y
-
D
A
V
H
V
A
K
T
P
L
M
--
D
A
L
F
-
N
D
P
K
H
-
F
R
S
I
C
AH
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
V
L
Q
G
A
S
L
V
D
D
A
L
E
S
--
G
E
IF
T
S
E
G
--
Y
R
Y
L
H
G
A
F
S
Q
P
G
R
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
V
Y
Q
I
L
K
H
A
G
A
N
G
A
-
K
-
R
-
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
K
T
S
F
K
F
T
D
E
L
E
E
V
L
A
KLREG
G
-
C
-
D
---
A
-
R
I
---
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
E
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
E
G
R
A
F
K
S
A
R
E
A
L
T
K
F
R
E
E
DA
N
--
I
S
D
Q
Y
Y
P
P
F
V
I
A
G
-----
D
D
----
G
RPIGT
I
E
D
G
D
A
V
L
C
F
N
F
R
G
--------
D
R
V
I
E
M
S
R
A
F
----
E
E
E
---------------
E
--
F
------
D
K
F
N
R
V
RLPKVRY
A
G
M
M
R
Y
D
G
D
L
G
--
I
P
NN
F
L
V
P
P
P
K
L
T
R
T
S
E
E
Y
L
I
G
S
G
C
N
I
F
A
L
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
L
S
--
E
E
R
E
T
F
CE
I
P
S
D
R
V
Q
-
F
N
Q
K
P
L
M
K
S
K
E
I
T
D
A
A
V
D
A
I
K
--
S
--
G
K
Y
D
M
I
R
I
N
Y
P
N
G
D
-
M
-
V
G
H
T
----------------------------------------------------------
G
D
L
K
A
T
I
T
S
L
E
A
V
D
Q
S
L
Q
R
L
K
E
A
V
D
S
V
---
N
-
G
V
F
L
I
T
A
D
H
G
N
S
D
D
M
V
--
Q
RDKKGKPVRDA
E
G
---------
N
---------
L
--
M
P
L
T
S
H
T
L
A
P
V
P
V
F
I
G
GAGLD--------
P
R
V
Q
M
R
-----
T
D
L
P
-
R
-
A
--
G
-
L
A
N
V
T
A
T
F
I
N
L
M
G
F
E
A
P
S
D
Y
E
P
S
L
I
E
V
25
HHSearch
44.40
26%
-58
- C2 -
3OT9
6
DEOB_BACCR
A:
[220-395]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
G
K
----
I
S
-
D
I
Y
D
G
E
G
V
T
E
S
L
-----------------------
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
--
M
--
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
-
F
G
H
R
----------------------------------------------------------
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
-----
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
----------------------------------------
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
-------------
S
P
S
M
K
E
GGQ--
E
L
P
L
-
R
-
Q
--
T
-
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
--
Y
G
T
S
F
L
N
29
HHSearch
43.79
24%
-58
- C2 -
3M7V
2
DEOB_STRMU
A:
[229-402]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
F
A
P
T
V
L
N
K
L
A
D
A
G
V
S
T
Y
A
V
G
K
----
I
N
-
D
I
F
N
G
S
G
I
T
N
D
M
G
----------------------
H
N
K
S
N
S
H
G
V
D
T
L
I
K
T
M
G
--
L
SA
F
T
K
G
F
S
F
T
N
L
V
D
F
D
-
A
L
Y
G
H
R
----------------------------------------------------------
R
N
A
H
G
Y
R
D
C
L
H
E
F
D
E
R
L
P
E
I
I
A
A
M
K
-----
V
D
D
L
L
L
I
T
A
D
H
G
N
D
P
T
Y
----------------------------------------
A
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
-------------
S
P
S
F
T
G
N
----
G
V
L
P
-
V
-
G
--
H
-
Y
A
D
I
S
A
T
I
A
D
N
F
G
V
D
T
A
M
--
I
G
E
S
F
L
D
28
HHSearch
41.61
18%
-46
- C2 -
3B5Q
10
?
A:
[98-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
P
T
L
G
S
L
F
S
E
S
G
Y
E
A
V
H
F
G
K
----
T
H
D
M
G
S
-
L
R
G
F
K
H
K
E
P
--
V
A
K
P
F
T
--
D
P
E
--
F
-
P
V
N
N
-
D
S
F
L
D
V
G
T
C
E
D
A
V
A
Y
L
S
NP
P
--
K
E
P
F
I
C
I
A
D
F
Q
N
P
H
-
N
-
I
C
G
F
I
G
E
N
A
G
V
H
T
D
RPISGPLPELPDNFDVEDWSNIP
T
P
V
Q
Y
I
CCSH
R
R
M
T
Q
A
A
HWN
E
E
N
Y
R
H
Y
I
A
A
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
N
T
I
V
V
I
M
A
D
H
G
D
G
M
A
S
H
--
R
-----------
M
V
---------
T
---------
K
--
H
I
S
F
Y
D
E
M
T
N
V
P
F
I
F
A
-------------
G
P
G
I
K
Q
Q
KK--
P
V
D
H
-
L
-
L
T
Q
P
-
T
L
D
L
L
P
T
L
C
D
L
A
G
I
A
V
P
A
E
K
A
G
I
S
L
A
P
44
Fugue
41.42
12%
-43
- C2 -
2ZKT
3
APGM_PYRHO
A:
[1-412]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
-----
K
-
R
-
K
---
G
-
L
L
---
I
I
L
D
G
-
L
G
D
-
R
P
I
K
-
E
-
L
N
G
L
T
P
L
E
Y
A
N
T
P
N
M
D
K
L
A
E
I
G
I
L
G
Q
Q
D
P
I
K
P
G
Q
--
P
--
A
G
S
D
T
A
H
L
S
I
F
G
------
Y
D
----
P
-----
Y
E
T
Y
R
G
R
G
F
F
E
A
L
G
V
G
L
D
L
S
KD
D
L
A
F
R
V
N
F
A
T
----
L
E
E
E
-----
A
H
-
E
-----
R
--
A
------
I
Q
E
E
V
D
-------
I
G
V
D
F
I
F
K
G
L
V
--
L
K
--
G
M
S
K
V
G
D
N
D
L
I
R
G
A
G
T
Y
P
N
I
P
M
K
F
T
E
Q
W
K
V
K
A
A
G
V
I
-----
A
V
A
L
V
K
G
--
V
A
R
A
V
G
--
F
D
V
Y
T
P
E
G
A
T
G
E
Y
N
T
N
E
M
A
K
A
K
K
A
V
E
L
L
K
--
D
--
Y
D
F
V
F
L
H
F
K
--
P
T
D
-
A
-
A
G
H
D
----------------------------------------------------------
N
K
P
K
L
K
A
E
L
I
E
R
A
D
R
M
I
G
Y
I
L
D
H
V
D
L
----
E
E
V
V
I
A
I
T
G
D
H
S
T
P
------------------------------------------
C
E
V
M
N
H
S
G
D
P
V
P
L
L
I
A
G
G
GVRTDDTKRFG
E
R
E
A
M
K
-----
G
G
L
G
-
R
-
I
--
R
-
G
H
D
I
V
P
I
M
M
D
L
M
N
R
S
E
K
F
G
A
-------