@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0420: (2015-12-01 )
MMKKVKLGILISGRGSNMQALMKACQNYGFPAEMACVISNNNKAAGLKVAEQAGMPTFVVENKPLDVDKIHEILVQHEVNLVCLAGFMRILKADFLNKWHGKVINVHPSLLPSFKGLNAQEQALKAGVKVTGCTVHYVTSEVDAGAIIAQAAVPVLPNDDIHSLSKRILSEEHKCYVEAVRLIAMLSRKLERP
Atome Classification :
(39 SA)
.........10........20........30........40........50........60..----.-----.....-70.--.......---80-----........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
K
K
V
K
L
G
I
L
I
SGRGS
N
M
Q
A
L
M
K
A
C
Q
NYGFP
A
E
M
A
C
V
I
SNNNKAAG
L
K
V
A
E
QAGM
P
T
F
V
VENK----P-----L
D
V
D
K
-
I
H
E
--
I
L
V
QHEV---
N
L
-----
V
C
L
A
G
F
M
R
I
L
K
A
D
F
L
N
K
WH
G
K
V
I
NVHP
S
L
L
P
S
FKGL
N
A
Q
E
Q
A
L
KAG
V
K
V
T
G
C
T
V
H
Y
V
TSEVDA
G
A
I
I
A
Q
AAVPVLPND
D
I
H
S
L
S
K
R
I
L
S
E
E
H
K
C
Y
V
E
A
V
R
L
I
A
M
L
S
R
K
LERP
110
HHSearch
98.54
59%
-146
- C4 -
3KCQ
1
?
A:
[7-194]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
-
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
----
P
-----
L
D
I
E
H
-
I
S
T
--
V
L
R
E
H
D
V
---
D
L
-----
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
1
PsiBlast_PDB
98.16
58%
-146
- C4 -
3KCQ
1
?
A:
[7-194]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
-
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
----
P
-----
L
D
I
E
H
-
I
S
T
--
V
L
R
E
H
D
V
---
D
L
-----
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
22
PsiBlast_CBE
97.86
58%
-143
- C4 -
3KCQ
1
?
C:
[7-194]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
E
E
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
----
P
-----
L
D
I
E
H
-
I
S
T
--
V
L
R
E
H
D
V
---
D
L
-----
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
23
PsiBlast_CBE
97.52
58%
-145
- C4 -
3KCQ
1
?
B:
[7-194]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
---
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
----
P
-----
L
D
I
E
H
-
I
S
T
--
V
L
R
E
H
D
V
---
D
L
-----
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
21
PsiBlast_CBE
96.43
58%
-145
- C4 -
3KCQ
1
?
D:
[7-194]
--
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
---
S
S
V
V
I
S
C
V
I
S
N
N
A
E
A
R
G
L
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
----
P
-----
L
D
I
E
H
-
I
S
T
--
V
L
R
E
H
D
V
---
D
L
-----
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
8
PsiBlast_PDB
92.25
50%
-141
- C4 -
1RBY
2
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
11
PsiBlast_PDB
92.12
50%
-143
- C4 -
1RC1
2
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
36
PsiBlast_CBE
92.11
50%
-142
- C4 -
1RBQ
3
PUR2_HUMAN
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
14
PsiBlast_PDB
92.10
50%
-142
- C4 -
4EW3
4
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
5
PsiBlast_PDB
91.93
50%
-140
- C4 -
1NJS
3
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
25
PsiBlast_CBE
91.90
49%
-146
- C4 -
1MEN
1
PUR2_HUMAN
B:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
33
PsiBlast_CBE
91.89
50%
-142
- C4 -
1RBY
2
PUR2_HUMAN
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
27
PsiBlast_CBE
91.77
49%
-146
- C4 -
1MEJ
1
PUR2_HUMAN
A:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
4
PsiBlast_PDB
91.60
50%
-147
- C4 -
1MEO
2
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
---
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
28
PsiBlast_CBE
91.59
50%
-144
- C4 -
1RC1
3
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
30
PsiBlast_CBE
91.58
50%
-140
- C4 -
1RBZ
2
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
9
PsiBlast_PDB
91.57
50%
-139
- C4 -
1RBZ
1
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
2
PsiBlast_PDB
91.57
49%
-148
- C4 -
1MEJ
1
PUR2_HUMAN
B:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
24
PsiBlast_CBE
91.56
49%
-143
- C4 -
1MEN
1
C:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
6
PsiBlast_PDB
91.56
50%
-141
- C4 -
1RBM
3
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
3
PsiBlast_PDB
91.50
49%
-141
- C4 -
1MEN
1
PUR2_HUMAN
A:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
13
PsiBlast_PDB
91.49
50%
-146
- C4 -
4EW2
4
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
-
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
7
PsiBlast_PDB
91.41
50%
-142
- C4 -
1RBQ
3
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
15
PsiBlast_PDB
91.38
50%
-145
- C4 -
1ZLY
2
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
35
PsiBlast_CBE
91.28
50%
-141
- C4 -
1RBQ
3
PUR2_HUMAN
C:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
26
PsiBlast_CBE
91.22
49%
-143
- C4 -
1MEJ
1
C:
[11-196]
---
R
I
L
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
34
PsiBlast_CBE
91.20
50%
-139
- C4 -
1RBQ
2
D:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
31
PsiBlast_CBE
91.17
50%
-138
- C4 -
1RBY
1
D:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
29
PsiBlast_CBE
91.13
50%
-138
- C4 -
1RC0
1
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
10
PsiBlast_PDB
91.05
50%
-141
- C4 -
1RC0
1
PUR2_HUMAN
A:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
32
PsiBlast_CBE
90.93
50%
-140
- C4 -
1RBY
2
PUR2_HUMAN
C:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
37
PsiBlast_CBE
90.52
50%
-140
- C4 -
1RBM
4
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
38
PsiBlast_CBE
90.51
50%
-144
- C4 -
1NJS
2
B:
[2-185]
-----
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
LYKN
R
-----
V
E
F
D
S
A
I
D
L
--
V
L
E
E
F
S
I
---
D
I
-----
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
N
18
PsiBlast_PDB
89.39
46%
-137
- C4 -
4DS3
5
?
A:
[6-192]
--
K
R
N
R
V
V
I
F
I
S
G
G
G
S
N
M
E
A
L
I
R
A
A
Q
A
P
G
F
P
A
E
I
V
A
V
F
S
D
K
A
E
A
G
G
L
A
K
A
E
A
A
G
I
A
T
Q
V
F
K
R
K
----
D
-----
F
A
S
K
E
-
A
H
E
D
A
I
L
A
A
L
D
V
L
KP
D
I
-----
I
C
L
A
G
Y
M
R
L
L
S
G
R
F
I
A
P
Y
E
G
R
I
L
N
I
H
P
S
L
L
P
L
F
P
G
L
H
T
H
Q
R
A
L
D
A
G
M
K
L
A
G
C
T
V
H
L
V
T
E
--
D
E
G
P
I
L
A
Q
A
A
V
P
V
L
D
G
D
T
A
E
T
L
A
A
R
V
L
K
A
E
H
R
L
Y
P
L
A
L
Q
K
F
A
A
G
M
V
L
S
A
--
113
HHSearch
86.29
36%
-144
- C4 -
1JKX
1
PUR3_ECOLI
A:
[1-192]
----
M
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
----
A
FDS
R
E
A
Y
D
R
E
-
L
I
H
--
E
I
D
M
Y
A
P
---
D
V
-----
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
41
PsiBlast_CBE
74.98
39%
-128
- C4 -
1C3E
2
PUR3_ECOLI
A:
[5-177]
--------
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
----
A
-----
F
D
S
R
E
-
A
Y
D
--
R
E
L
I
H
E
I
---
D
M
YAPD
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
57
PsiBlast_CBE
74.79
39%
-127
- C4 -
1C2T
2
PUR3_ECOLI
A:
[5-177]
--------
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
----
A
-----
F
D
S
R
E
-
A
Y
D
--
R
E
L
I
H
E
I
---
D
M
YAPD
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
56
PsiBlast_CBE
74.68
39%
-126
- C4 -
1C2T
2
PUR3_ECOLI
B:
[5-177]
--------
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
----
A
-----
F
D
S
R
E
-
A
Y
D
--
R
E
L
I
H
E
I
---
D
M
YAPDV
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
40
PsiBlast_CBE
74.51
39%
-125
- C4 -
1C3E
2
PUR3_ECOLI
B:
[5-177]
--------
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
D
A
F
G
L
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
----
A
-----
F
D
S
R
E
-
A
Y
D
--
R
E
L
I
H
E
I
---
D
M
YAPDV
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N