@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0636: (2015-12-03 )
MRDNIIIITGITASGKSELCDNLIKKYGNISIVNCDSKQVYKEIPIITAQPPKQEEFYRLYGCVPAKENYSVGLWLEDLKGEVDHALENARMPIITGGSGLYISSLINSLSPIPKVSEEIRKNVSELRKNLSKEEFYKLVLSKDSKIQGKISTNDLHRLSRALEVITATGKSIFVWQESRQLPLFDNFKIYTILPKREDVYRKINSRFVTMIESGAVDEVKKLLNMNLAPHLPAMRAHGVPEIIKYLKGKITLSEAIQIAQTNTRHYAKRQYTWFKNQFPNSEVIDCANKLIEFEIF
Atome Classification :
(20 SA)
.........10........20........30........40........50...---.---.---.---..60......-..70........80......--..90........100......--.110-......----.120.......130.......140.......150.......160.......170..-.....180.....-..190-----..-.-....200.......210..-----.....220.-.-.-.-------.-.-------.-------230......-----.240....------...250---------------.-----------........260.......270......-----.280-----------------........290.....---------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRD
N
I
I
I
I
TGITAS
G
K
S
E
L
C
D
N
L
I
K
KYG
N
I
S
I
V
NCD
S
K
Q
V
Y
K
EI
P
I
I
TAQPP
K
Q
---
E
---
E
---
F
---
Y
R
L
YGCVPAK-EN
Y
S
V
G
L
W
L
E
D
LK
G
E
V
D
H
A
L
--ENARM
P
I
I
TGGS
G
L
Y
I
S
S
L
I
N
--SLSP-I
P
K
V
S
E
----
E
I
R
K
N
V
S
E
L
R
K
NL
S
K
E
E
F
Y
K
L
V
LSKDS
K
I
Q
G
KIS
T
N
D
L
H
R
L
S
R
A
L
E
V
I
TATG
K
S
I
F
-
V
W
QESRQLPLFDN-
F
K
I
Y
T
-----IL-P-K
R
E
D
V
Y
R
K
I
N
S
R
F
V
T
M
I
ES-----G
A
V
D
E
V
K
K
L
-L-N-M-------N-L-------A-------PHL
P
A
M
R
AH-----
G
V
P
E
I
I
K
Y
------
L
KG
K
-----------------
I
-----------
T
L
S
E
A
I
Q
I
AQTNT
R
H
Y
A
K
R
Q
Y
T
W
F
KNQ-----FPN------------------
S
E
V
I
D
C
A
N
K
L
I
E
F
EIF---------------------------------------------------------------------------------
4
PsiBlast_PDB
94.59
29%
-106
- C5 -
2QGN
1
MIAA_BACHD
A:
[2-304]
-
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
-
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
---
E
---
M
---
D
G
V
P
H
H
L
I
D
I
K
D
P
S
-
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
--
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
QF
N
L
G
---------------------------------------------------------------------------
E
T
P
S
P
Y
N
-
L
V
M
I
G
-----
L
T
-
M
-
E
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
-----
G
L
I
D
E
A
K
K
L
-
Y
-
D
-
R
-------
G
-
I
-------
R
-------
D
-
C
Q
S
V
Q
A
I
-----
G
Y
K
E
M
Y
D
Y
------
L
D
G
N
-----------------
V
-----------
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
AN
V
T
W
F
D
M
------------------
T
D
V
-
D
F
D
K
K
I
M
E
I
H
N
F
---------------------------------------------------------------------------------
41
HHSearch
92.12
29%
-93
* C5 *
3FOZ
-
MIAA_ECOLI
A:
[8-299]
S
L
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
-
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
---
E
L
L
A
A
---
P
---
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
--
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
--
G
L
S
P
-
L
P
S
A
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
-
E
L
T
Q
T
S
G
D
-
A
L
P
Y
Q
V
H
Q
F
A
-----
I
A
P
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
-----
G
F
E
A
E
V
R
A
L
-
F
-
A
-
R
-------
G
D
L
-------
H
-------
T
D
L
P
S
I
R
C
V
-----
G
Y
R
Q
M
W
S
Y
------
L
E
G
E
-----------------
I
-----------
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
-----
E
G
V
-------------------
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
---------------------------------------------------------------------------------
42
HHSearch
90.69
28%
-109
- C5 -
3CRM
-
MIAA_PSEAE
A:
[3-305]
S
L
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
-
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
-
A
R
--
Y
---
P
---
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
--
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
--
G
---------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
-----
I
A
-
P
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
-----
G
F
I
A
E
V
E
A
L
-
H
-
A
-
R
-------
S
D
L
-------
H
-------
A
G
L
P
S
I
R
A
V
-----
G
Y
R
Q
V
W
D
Y
------
L
D
G
K
-----------------
L
-----------
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
-----
S
H
L
-------------------
H
W
M
D
S
L
A
G
D
N
L
P
R
A
L
---------------------------------------------------------------------------------
2
PsiBlast_PDB
89.62
30%
-89
- C5 -
2ZXU
2
MIAA_ECOLI
A:
[13-288]
-----
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
-
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
---
E
---
L
---
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
--
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
--
G
L
S
P
-
L
P
S
A
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
-
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
-
V
H
Q
F
A
-----
I
A
-
P
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
-----
G
F
E
A
E
V
R
A
L
-
F
A
R
-
G
-------
D
-
L
-------
H
-------
T
D
L
P
S
I
R
C
V
-----
G
Y
R
Q
M
W
S
Y
------
L
E
G
E
-----------------
I
-----------
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
-----
E
G
V
------------------
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
---------------------------------------------------------------------------------
3
PsiBlast_PDB
89.24
30%
-86
- C5 -
2ZM5
-
MIAA_ECOLI
A:
[13-288]
-----
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
-
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
---
E
---
L
---
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
--
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
--
G
L
S
P
-
L
P
S
A
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
-
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
-
V
H
Q
F
A
-----
I
A
-
P
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
-----
G
F
E
A
E
V
R
A
L
-
F
A
R
-
G
-------
D
-
L
-------
H
-------
T
D
L
P
S
I
R
C
V
-----
G
Y
R
Q
M
W
S
Y
------
L
E
G
E
-----------------
I
-----------
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
-----
E
G
V
------------------
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
---------------------------------------------------------------------------------
1
PsiBlast_PDB
89.07
30%
-88
- C5 -
3FOZ
-
MIAA_ECOLI
A:
[13-288]
-----
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
-
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
---
E
---
L
---
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
--
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
--
G
L
S
P
-
L
P
S
A
D
P
----
E
V
R
A
R
I
E
Q
Q
A
A
E
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
-
E
L
T
Q
T
S
G
D
A
L
P
Y
Q
-
V
H
Q
F
A
-----
I
A
-
P
A
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
-----
G
F
E
A
E
V
R
A
L
-
F
A
R
-
G
-------
D
-
L
-------
H
-------
T
D
L
P
S
I
R
C
V
-----
G
Y
R
Q
M
W
S
Y
------
L
E
G
E
-----------------
I
-----------
S
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
-----
E
G
V
------------------
H
W
L
D
S
E
K
P
E
Q
A
R
D
E
V
L
---------------------------------------------------------------------------------
6
PsiBlast_PDB
87.21
28%
-102
- C5 -
3EPH
5
MOD5_YEAST
A:
[4-289]
----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
-
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
---
R
---
E
GIP
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
----
K
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
-
L
F
L
W
------
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
Y
Y
-------
S
-
Q
-------
N
-------
K
F
T
P
E
Q
C
E
N
-----
G
V
W
Q
V
I
G
F
KEFLPW
L
T
-------------------
V
-----------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
------------------
D
I
K
G
D
I
Y
L
L
D
A
T
D
L
S
Q
---------------------------------------------------------------------------------
10
PsiBlast_PDB
86.38
29%
-102
- C5 -
3CRM
-
MIAA_PSEAE
A:
[8-294]
-----
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
-
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
---
Y
---
P
---
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
--
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
--
G
--------------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
-----
G
F
I
A
E
V
E
A
L
H
A
-
R
-
S
-------
D
-
L
-------
H
-------
A
G
L
P
S
I
R
A
V
-----
G
Y
R
Q
V
W
D
Y
------
L
D
G
K
-----------------
L
-----------
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
-----
S
H
L
------------------
H
W
M
D
S
L
A
G
D
N
L
P
R
A
L
R
---------------------------------------------------------------------------------
59
Fugue
86.34
26%
-98
- C5 -
3EPH
6
MOD5_YEAST
A:
[1-409]
-
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
-
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
---
R
EGI
P
---
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
----
K
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
-
E
T
F
N
E
Q
K
I
T
L
K
F
D
-
T
L
F
L
W
-----
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
-
Y
Y
S
QNKFT
P
-
E
-------
Q
-------
C
E
N
G
V
W
Q
V
I
-----
G
F
K
E
F
L
P
W
------
L
T
V
------------------------------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
D
I
KGD
I
Y
L
L
D
ATDLSQWD
T
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
NRPIKQERAPKALEELLSKGETTMKKLDDW
T
H
Y
T
CNVCRNADGK
N
V
V
A
I
G
E
K
Y
W
K
I
H
L
G
S
R
R
H
K
S
N
L
K
R
N
T
R
Q
A
D
F
E
K
W
K
I
11
PsiBlast_PDB
85.67
29%
-100
- C5 -
3CRQ
2
MIAA_PSEAE
A:
[8-294]
-----
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
-
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
---
Y
---
P
---
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
--
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
--
G
--------------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
-----
G
F
I
A
E
V
E
A
L
H
A
-
R
-
S
-------
D
-
L
-------
H
-------
A
G
L
P
S
I
R
A
V
-----
G
Y
R
Q
V
W
D
Y
------
L
D
G
K
-----------------
L
-----------
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
-----
S
H
L
------------------
H
W
M
D
S
L
A
G
D
N
L
P
R
A
L
R
---------------------------------------------------------------------------------
43
HHSearch
85.52
28%
-94
- C5 -
3EPH
5
MOD5_YEAST
A:
[1-292]
-
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
-
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
REG
I
---
P
---
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
K---
L
T
R
K
Q
L
D
-
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
-
E
T
F
N
E
Q
K
I
-
T
L
K
F
D
T
L
F
L
W
-----
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
-
Y
-------
Y
-
S
QNKFTPE
Q
-------
C
E
N
G
V
W
Q
V
I
-----
G
F
K
E
F
L
P
W
------
L
T
--------------------V----------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
------------------
D
I
K
G
D
I
Y
L
L
D
A
T
D
L
S
Q
---------------------------------------------------------------------------------
12
PsiBlast_PDB
84.97
29%
-101
- C5 -
3CRR
4
MIAA_PSEAE
A:
[8-294]
-----
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
-
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
---
Y
---
P
---
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
--
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
--
G
--------------------------------------------------------------------------------------
L
P
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
-----
G
F
I
A
E
V
E
A
L
H
A
-
R
-
S
-------
D
-
L
-------
H
-------
A
G
L
P
S
I
R
A
V
-----
G
Y
R
Q
V
W
D
Y
------
L
D
G
K
-----------------
L
-----------
S
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
-----
S
H
L
------------------
H
W
M
D
S
L
A
G
D
N
L
P
R
A
L
R
---------------------------------------------------------------------------------
8
PsiBlast_PDB
84.83
28%
-98
- C5 -
3EPK
4
MOD5_YEAST
A:
[4-289]
----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
-
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
---
R
---
E
GIP
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
----
K
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
-
L
F
L
W
------
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
Y
Y
-------
S
-
Q
-------
N
-------
K
F
T
P
E
Q
C
E
N
-----
G
V
W
Q
V
I
G
F
KEFLPW
L
T
-------------------
V
-----------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
------------------
D
I
K
G
D
I
Y
L
L
D
A
T
D
L
S
Q
---------------------------------------------------------------------------------
7
PsiBlast_PDB
84.63
28%
-101
- C5 -
3EPJ
2
MOD5_YEAST
A:
[4-289]
----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
-
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
---
R
---
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
----
K
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
-
L
F
L
W
------
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
Y
Y
-------
S
-
Q
-------
N
-------
K
F
T
P
E
Q
C
E
N
-----
G
V
W
Q
V
I
G
F
KEFLPW
L
T
-------------------
V
-----------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
------------------
D
I
K
G
D
I
Y
L
L
D
A
T
D
L
S
Q
---------------------------------------------------------------------------------
9
PsiBlast_PDB
82.31
28%
-96
- C5 -
3EPL
1
MOD5_YEAST
A:
[4-289]
----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
-
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
---
E
---
R
---
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
--
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
--
K
R
V
D
-
T
K
S
S
E
R
----
K
L
T
R
K
Q
L
D
I
L
E
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
T
F
N
E
Q
K
I
T
L
K
F
D
T
-
L
F
L
W
------
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
-----
G
A
L
Q
E
I
K
Q
L
-
Y
-
E
Y
Y
-------
S
-
Q
-------
N
-------
K
F
T
P
E
Q
C
E
N
-----
G
V
W
Q
V
I
G
F
KEFLPW
L
T
-------------------
V
-----------
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
-----
L
I
P
------------------
D
I
K
G
D
I
Y
L
L
D
A
T
D
L
S
Q
---------------------------------------------------------------------------------
44
HHSearch
71.57
21%
-92
- C5 -
3A8T
2
IPT_HUMLU
A:
[39-292]
-
K
E
K
L
L
V
L
M
G
A
T
G
T
G
K
S
R
L
S
I
D
L
A
A
-
H
F
P
L
E
V
I
N
S
D
K
M
Q
V
Y
K
G
L
D
I
T
T
N
K
I
S
V
P
---
D
RGG
V
---
P
---
H
H
L
L
G
E
V
D
P
A
R
G
E
L
T
P
A
D
F
R
S
L
A
G
K
A
V
S
E
I
T
--
G
R
R
K
L
P
V
L
V
G
G
S
N
S
F
I
H
A
L
L
V
--
D
R
F
D
-
S
S
--
G
P
----------------------------------------------------------------------
E
L
R
Y
D
C
C
F
L
W
-----
V
D
-
V
-
S
V
K
V
L
T
D
Y
L
A
K
R
V
D
D
M
L
E
L
-----
G
M
F
D
E
L
A
E
F
-
Y
-
S
-
P
-------
E
-
D
-------
E
DHDEDSA
T
R
T
G
L
R
K
A
I
-----
G
V
P
E
F
D
R
Y
------
F
E
K
F
RPGDVEGEDPGR
D
R
V
R
R
G
-----------
A
F
E
E
A
V
R
A
I
K
E
N
T
C
H
L
A
K
R
Q
I
G
K
I
L
R
L
-----
K
G
A
------------------
G
W
D
L
R
R
L
D
A
T
E
S
F
R
A
A
---------------------------------------------------------------------------------
40
HHSearch
56.37
29%
6
- C5 -
3EXA
-
MIAA_BACHD
A:
[2-291]
-
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
-
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
---
E
MDG
V
---
P
---
H
H
L
I
D
I
K
D
P
S
-
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
--
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
--
Q
F
N
L
G
D
I
R
A
D
E
----
D
Y
R
H
E
L
E
A
F
V
N
S
Y
G
V
Q
A
L
H
D
K
L
S
K
I
D
P
K
A
A
A
A
I
H
P
N
N
Y
R
R
V
I
R
A
L
E
I
I
K
L
T
G
---------------
S
P
Y
N
L
V
M
I
G
-----
L
T
-
M
-
E
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
-----
G
L
I
D
E
A
K
K
L
-
Y
-
D
-
R
-------
G
-
I
---------------
R
D
C
Q
S
V
Q
A
I
-----
G
Y
K
E
M
Y
D
Y
------
L
D
G
N
-----------------
V
-----------
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
-----
A
N
V
-------------------
T
W
F
D
M
T
D
V
D
F
D
K
K
I
M
---------------------------------------------------------------------------------
45
HHSearch
54.58
17%
-55
- C5 -
2ZE6
2
IPTZ_AGRFC
A:
[1-227]
--
M
L
L
H
L
I
Y
G
P
T
C
S
G
K
T
D
M
A
I
Q
I
A
Q
-
E
T
G
W
P
V
V
A
L
D
R
V
Q
C
C
P
Q
I
A
T
G
S
G
R
P
L
E
S
---
E
LQS
T
---
R
---
R
I
Y
L
D
S
R
P
L
T
-
E
G
I
L
D
A
E
--
S
A
H
R
R
L
I
F
E
V
D
W
R
K
S
E
E
G
L
I
L
E
G
G
S
I
S
L
L
N
C
M
A
K
--
S
P
F
-----------------------------------------------------------------------
W
R
-----
S
G
F
Q
-
W
H
V
K
R
-----
L
R
-
L
G
D
S
D
A
F
L
T
R
A
K
Q
R
V
A
E
M
F
A
I
REDRP
S
L
L
E
E
L
A
E
L
-
W
-
N
-----------------------------
Y
P
A
A
R
P
I
L
E
D
ID
G
Y
R
C
A
I
R
F
------
A
R
K
H
D----------------
L
AISQLPNIDA
G
R
H
V
E
L
I
E
A
I
A
N
E
Y
L
E
H
A
L
S
Q
E
R
D
F
P
Q
W
-----
P
E
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.72
29%
8
- C5 -
3EXA
-
MIAA_BACHD
A:
[2-304]
-
K
E
K
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
-
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
---
E
---
M
---
D
G
V
P
H
H
L
I
D
I
K
D
P
S
-
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
--
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
QF
N
L
G
D
-
I
-
R
A
D
E
----
D
Y
R
H
E
L
E
A
F
V
N
S
Y
G
V
Q
A
L
H
D
K
L
S
K
I
D
P
K
A
A
A
A
I
H
P
N
N
Y
R
R
V
I
R
A
L
E
I
I
K
L
T
G
--------------
S
P
Y
N
-
L
V
M
I
G
-----
L
T
-
M
-
E
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
-----
G
L
I
D
E
A
K
K
L
-
Y
-
D
-
R
-------
G
-
I
-------
R
-------
D
-
C
Q
S
V
Q
A
I
-----
G
Y
K
E
M
Y
D
Y
------
L
D
G
N
-----------------
V
-----------
T
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
AN
V
T
W
F
D
M
------------------
T
D
V
-
D
F
D
K
K
I
M
E
I
H
N
F
---------------------------------------------------------------------------------
39
HHSearch
50.72
28%
2
- C5 -
3D3Q
-
MIAA_STAES
A:
[6-297]
-
K
P
F
L
I
V
I
V
G
P
T
A
S
G
K
T
E
L
S
I
E
V
A
K
-
K
F
N
G
E
I
I
S
G
D
S
M
Q
V
Y
Q
G
M
D
I
G
T
A
K
V
T
T
E
---
E
MEG
I
---
P
---
H
Y
M
I
D
I
L
P
P
D
-
A
S
F
S
A
Y
E
F
K
K
R
A
E
K
Y
I
K
D
I
T
--
R
R
G
K
V
P
I
I
A
G
G
T
G
L
Y
I
Q
S
L
L
Y
--
N
Y
A
F
-
E
--
I
S
E
D
K
M
K
Q
V
K
L
K
L
K
-
E
L
E
H
L
N
N
N
K
L
H
E
Y
L
A
S
F
D
K
E
S
A
K
D
I
H
P
N
N
R
K
R
V
L
R
A
I
E
Y
Y
L
K
T
K
K
L
L
S
-
S
R
K
K
V
Q
Q
F
-
T
E
N
Y
D
T
L
L
I
G
-----
I
E
-
M
-
S
R
E
T
L
Y
L
R
I
N
K
R
V
D
I
M
L
G
H
-----
G
L
F
N
E
V
Q
H
L
-
V
-
E
-
Q
-------
G
-
F
-------
E
--------
A
S
Q
S
M
Q
A
I
-----
G
Y
K
E
L
V
P
V
------
I
K
G
N
-----------------
I
-----------
S
M
E
N
A
V
E
K
L
K
Q
H
S
R
Q
Y
A
K
R
Q
L
T
W
F
K
N
K
-----
M
N
V
-------------------
H
W
L
N
K
E
R
M
S
L
Q
M
M
L
D
---------------------------------------------------------------------------------