@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0109: (2016-03-12 )
MMIGSSFIPLQRVLMYFINPNDSMDQFTLEVLRLPRITLAILAGAALGMSGLMLQNVLKNPIASPDIIGITGGASLSAVVFIAFFSHLTIHLLPLFAVLGGAVAMMILLVFQTKGQIRPTILIIIGISMQTLFIALVQGLLITTKQLSAAKAYTWLVGSLYGATFKDTIILGMVILAVVPLLFLVIPKMKISILDDPVAIGLGLHVQRMKLIQLITSTILVSMAISLVGNIGFVGLIAPHIAKTIVRGSYAKKLLMSAMIGAISIVIADLIGRTLFLPKEVPAGVFIAAFGAPFFIYLLLTVKKL
Atome Classification :
(20 SA)
-------------.........10....------..-..20..-------.----.....30.----....-...-------40..-.----------------.....-50...----.....60.........70.--...-------....80..--------..------.-------.-..-.90.--.------...-------...-----100----..-...---------..--110...----.------..-.----120.-------------------.....-..---130---------.----------......----140..-.-.------------------....150----.........-160---....-----------....170--.---------------.......180-.-.-.-...-.---------.---.190---...----------..--------------..200.-......210...-----..---..220......--------.------230..--.-....240..--------....-----.250.----...--..-.--260....--.--..270.----------....---..-280-------.---------------..-------.-----...-..290.----..-------------.-----....300...-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MMIGS
S
F
I
P
L
Q
R
V
L
M
------
Y
F
-INPND
S
-------
M
----
D
Q
F
T
L
E
V
L
----RLP
R
-
I
T
L
-------
A
I
L
A
-
G
----------------
A
A
L
G
M
-
S
G
L
M
L
----
Q
N
V
L
KN-PIASP
D
I
I
G
ITG--G
A
S
-------
L
S
A
V
V
-
F
I
--------
A
F
------
F
-------
S
-
H
L
-
T
I
H
L
--
L
------
P
L
F
-------
A
V
L
-----
G
G
A
----
V
A
-
M
M
I
---------
L
L
--VFQTKG----Q------IR-
P
----
T
I
-
L
-------------------
I
I
IGI-
S
M
---
Q
T
L
---------
F
----------
I
A
L
V
Q
G
----
L
-
L
I
T
-
T
-
K
------------------
Q
L
S
A
A
------
K
A
Y
T
W
L
V
G
S
-
L
-Y---GA
T
F
-----------
K
D
T
I
I
L
---
G
---------------
M
V
I
L
A
V
V
P
---
L
-
L
-
F
-
L
V
I-P---------
K
---
M
K
I
S
---ILD----------DP--------------VAIGL
G
-
L
H
V
Q
R
M
K
L
I
Q
L
I
-----
T
S
---
T
I
L
V
S
M
A
I
S
L
V
--------G------NI
G
F
V
--
G
-
L
I
A
P
H
I
A
K
T
--------
I
V
R
G
-----
S
Y
A
K
K
----
L
L
M
--
S
A
-
M
--
I
G
A
I
S
I
V
--
I
--
A
D
L
I
G
R
----------TLFL---PK-E---------V---------------PA-------
G
-----
V
F
I
-AAFG-
A
----
P
F
-------------
F
-----
I
Y
L
L
L
T
VKKL-----------------------------------------
1
PsiBlast_PDB
97.22
28%
-155
- C5 -
2NQ2
-
Y1471_HAEIN
A:
[51-330]
-----------------------------------------
D
P
-------
V
----
Q
Q
Q
V
I
F
Q
V
----
R
L
P
R
-
I
L
T
-------
A
L
C
V
-
G
----------------
A
G
L
A
L
-
S
G
V
V
L
----
Q
G
I
F
R
N
-
P
L
V
N
P
H
I
I
G
V
T
S
--
G
S
A
-------
F
G
G
T
---
L
--------
A
I
------
F
-------
F
-
G
F
-
S
L
Y
G
--
L
------
F
T
S
-------
T
I
L
-----
F
G
F
----
G
T
-
L
A
L
---------
V
F
--
L
F
S
F
K
---------------
S
----
L
L
M
L
-------------------
I
L
I
G
M
-
I
L
---
S
G
L
---------
F
----------
S
A
L
V
S
L
----
L
Q
Y
I
S
-
D
-
T
------------------
E
E
K
L
P
------
S
I
V
F
W
L
M
G
S
-
F
-
A
---
T
S
N
W
-----------
E
K
L
L
F
F
---
F
---------------
V
P
F
L
L
C
S
S
---
I
-
L
-
L
-
S
L
S
-
W
---------
R
---
L
N
L
L
---
S
L
D
----------
E
K
--------------
E
A
K
A
L
G
-
V
K
M
A
P
L
R
W
L
V
I
F
-----
L
S
---
G
S
L
V
A
C
Q
V
A
I
S
--------
G
------
S
I
G
W
V
--
G
-
L
I
I
P
H
L
S
R
M
--------
L
V
G
A
-----
N
H
Q
S
L
----
L
P
C
--
T
M
-
L
--
V
G
A
T
Y
M
L
--
L
--
V
D
N
V
A
R
----------
S
L
S
----
D
A
-
E
---------
I
---------------
P
I
-------
S
-----
I
L
T
-
A
L
I
G
-
A
----
P
L
-------------
F
-----
G
V
L
V
Y
K
L
--------------------------------------------
5
PsiBlast_PDB
90.36
26%
-150
- C5 -
1L7V
-
BTUC_ECOLI
A:
[37-324]
-----------------------------------
W
-
I
S
P
G
D
W
-------
F
T
P
R
G
E
L
F
V
W
Q
I
-----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
G
Q
L
-
P
N
W
A
--
L
------
G
L
C
-------
A
I
A
-----
G
A
L
----
I
I
-
T
L
I
---------
L
L
--
R
F
A
R
R
-----
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
C
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
----------------------
W
L
M
L
A
L
I
P
---
V
-
L
-
L
-
W
I
C
-
C
---------
Q
---
S
R
P
M
N
M
L
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
L
--------
C
G
L
T
-----
D
H
R
V
L
----
L
P
G
--
C
A
-
L
--
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
---
A
A
-
E
---------
L
---------------
P
I
-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
4
PsiBlast_PDB
88.26
27%
-146
* C5 *
4FI3
-
BTUC_ECOLI
A:
[60-347]
-----------------------------------
W
-
I
S
P
G
D
W
-------
F
T
P
R
G
E
L
F
V
W
Q
I
-----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
G
Q
L
-
P
N
W
A
--
L
------
G
L
S
-------
A
I
A
-----
G
A
L
----
I
I
-
T
L
I
---------
L
L
--
R
F
A
R
R
-----
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
S
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
W
L
M
----------------------
L
A
L
I
P
---
V
-
L
-
L
-
W
I
S
-
S
---------
Q
S
R
P
M
N
M
L
---
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
----------
L
S
G
-----
L
T
D
H
R
----
V
L
L
P
G
C
A
-
L
--
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
---
A
A
-
E
---------
L
---------------
P
I
-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
3
PsiBlast_PDB
87.80
27%
-147
- C5 -
4DBL
-
BTUC_ECOLI
A:
[60-347]
-----------------------------------
W
-
I
S
P
G
D
W
-------
F
T
P
R
G
E
L
F
V
W
Q
I
-----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
G
Q
L
-
P
N
W
A
--
L
------
G
L
S
-------
A
I
A
-----
G
A
L
----
I
I
-
T
L
I
---------
L
L
--
R
F
A
R
R
-----
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
S
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
W
L
M
----------------------
L
A
L
I
P
---
V
-
L
-
L
-
W
I
S
-
S
---------
Q
S
R
P
M
N
M
L
---
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
----------
L
S
G
-----
L
T
D
H
R
----
V
L
L
P
G
C
A
-
L
--
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
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A
A
-
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---------
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---------------
P
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-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
2
PsiBlast_PDB
87.07
27%
-148
- C5 -
4R9U
2
BTUC_ECOLI
A:
[44-331]
-----------------------------------
W
-
I
S
P
G
D
W
-------
F
T
P
R
G
E
L
F
V
W
Q
I
-----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
G
Q
L
-
P
N
W
A
--
L
------
G
L
S
-------
A
I
A
-----
G
A
L
----
I
I
-
T
L
I
---------
L
L
--
R
F
A
R
R
-----
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
S
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
W
L
M
----------------------
L
A
L
I
P
---
V
-
L
-
L
-
W
I
S
-
S
---------
Q
S
R
P
M
N
M
L
---
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
----------
L
S
G
-----
L
T
D
H
R
----
V
L
L
P
G
C
A
-
L
--
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
---
A
A
-
E
---------
L
---------------
P
I
-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
6
PsiBlast_PDB
86.50
26%
-144
- C5 -
2QI9
-
BTUC_ECOLI
A:
[37-324]
-----------------------------------
W
-
I
S
P
G
D
W
-------
F
TPRG
E
L
F
V
W
Q
I
-----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
G
Q
L
-
P
N
W
A
--
L
------
G
L
S
-------
A
I
A
-----
G
A
L
----
I
I
-
T
L
I
---------
L
L
--
R
F
A
R
R
-----
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
S
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
----------------------
W
L
M
L
A
L
I
P
---
V
-
L
-
L
-
W
I
S
-
S
---------
Q
---
S
R
P
M
N
M
L
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
----------
L
S
G
-----
L
T
D
H
R
----
V
L
L
--
P
G
-
C
A
L
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
---
A
A
-
E
---------
L
---------------
P
I
-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
8
HHSearch
82.36
24%
-138
- C5 -
2QI9
-
BTUC_ECOLI
A:
[32-324]
--------------
S
A
G
E
Q
W
I
S
P
G
D
W
F
--------------
T
P
-------
R
----
G
E
L
F
V
W
Q
I
----
R
L
P
R
-
T
L
A
-------
V
L
L
V
-
G
----------------
A
A
L
A
I
-
S
G
A
V
M
----
Q
A
L
F
E
N
-
P
L
A
E
P
G
L
L
G
V
S
N
--
G
A
G
-------
V
G
L
I
A
-
A
V
--------
L
L
------
G
-------
Q
-
G
Q
L
P
N
W
A
--
L
------
G
L
S
-------
A
I
A
-----
G
A
L
----
I
I
T
L
I
L
---------
L
R
--
F
A
R
R
------
H
------
L
S
-
T
----
S
R
-
L
-------------------
L
L
A
G
V
-
A
L
---
G
I
I
---------
S
----------
S
A
L
M
T
W
----
A
-
I
Y
F
-
S
-
T
------------------
S
V
D
L
R
------
Q
L
M
Y
W
M
M
G
G
-
F
-
G
---
G
V
D
W
-----------
R
Q
S
W
L
M
---
L
---------------
A
-
L
I
P
V
L
L
---
W
-
I
-
S
-
S
Q
S
-
R
---------
P
---
M
N
M
L
---
A
L
G
----------
E
I
--------------
S
A
R
Q
L
G
-
L
P
L
W
F
W
R
N
V
L
V
A
-----
A
T
---
G
W
M
V
G
V
S
V
A
L
A
--------
G
------
A
I
G
F
I
--
G
-
L
V
I
P
H
I
L
R
L
--------
S
G
L
T
-----
D
H
R
V
L
----
L
P
G
--
C
A
-
L
--
A
G
A
S
A
L
L
--
L
--
A
D
I
V
A
R
----------
L
A
L
A
---
A
A
-
E
---------
L
---------------
P
I
-------
G
-----
V
V
T
-
A
T
L
G
-
A
----
P
V
-------------
F
-----
I
W
L
L
L
K
A
--------------------------------------------
21
Fugue
75.17
21%
-173
* C6 *
3FHC
-
NU214_HUMAN
A:
[9-405]
---------I
P
E
R
E
M
K
D
F
Q
F
R
A
L
K
K
V
R
I
------
F
D
-
S
P
E
E
L
P
-------
K
----
E
R
S
S
L
--
L
----
A
V
S
N
-
K
Y
G
-------
L
V
F
A
-
G
----------------
G
A
S
G
L
-
Q
I
F
P
T
----
K
N
L
L
I
Q
-
N
K
P
G
D
D
P
N
K
I
V
D
--
K
V
Q
-------
G
L
L
V
P
-
M
K
--------
F
P
------
I
-------
H
-
H
L
-
A
L
S
C
DN
L
------
T
L
S
-------
A
C
M
M
S
SEY
G
S
I
----
I
A
-
F
F
D
---------
V
R
--
T
F
S
N
E
A
----
Q
------
K
R
-
P
F
A
Y
H
K
L
-
L
KDAGGMVI
D
M
K
W
NPTVPS
M
V
A
V
C
L
-
A
D
---
G
S
I
---------
A
----------
V
L
Q
V
T
E
----
T
-
V
K
V
-
C
-
A
------------------
T
L
P
S
T
------
V
A
V
T
S
V
C
W
S
-
P
-
K
---
G
K
Q
L
-----------
A
V
G
K
Q
N
---
G
---------------
T
V
V
Q
Y
L
P
T
---
L
Q
E
-
K
-
K
V
I
-
P
---------
C
---
P
P
F
Y
---
E
S
D
----------
H
P
--------------
V
R
V
L
D
V
-
L
W
I
G
T
Y
V
F
A
I
V
Y
-----
A
A
ADG
T
L
E
T
S
P
D
V
V
M
A
L
L
P
KKEEK
H
------
P
E
I
F
V
--
N
-
F
M
E
P
C
Y
G
S
C
--------
T
E
R
Q
H
H
Y
Y
L
S
Y
I
E
E
WD
L
V
L
A
A
--
S
A
-
A
--
S
T
E
V
S
I
L
--
A
R
Q
S
D
Q
I
N
W
----------
E
S
W
L
---
L
E
-
D
---------
S
SRA
E
L
P
V
T
DKS
D
D
S
L
P
M
-------
G
-----
V
V
V
-
D
Y
T
N
-
A
----
P
--------------------
V
L
M
L
L
S
T
D
G
V
L
C
P
F
Y
M
I
N---------------------------------
16
Fugue
74.86
21%
-187
* C3 *
4BUC
16
MURD_THEMA
A:
[16-448]
---PRGSH
M
K
I
G
F
L
G
F
G
K
S
N
R
S
L
L
K
Y
L
L
N
H
Q
E
A
K
F
F
-
V
S
E
A
K
T
-------
L
----
D
G
E
T
K
K
F
L
----
E
E
H
S
-
V
E
Y
E
E
GGHTE
K
L
L
D
-
C
D
V
V
Y
V
S
PGIKPDT
S
M
I
E
L
L
S
S
-
R
G
V
K
L
S
T
E
L
Q
F
F
L
D
N
--
V
D
P
K
K
V
V
G
I
T
G
TD
G
K
S
-------
T
A
T
A
L
M
Y
H
--------
V
L
------
S
-------
G
-
R
G
-
F
K
T
F
--
L
G
G
NFGT
P
A
V
-------
E
A
L
-----
E
G
E
----
Y
D
-
Y
Y
V
---------
L
E
M
S
S
F
Q
L
F
W
----
S
------
E
R
-
P
YL--
S
N
-
F
-------------------
L
V
L
N
I
-
S
E
---
D
H
L
DWHSS----
F
----------
K
E
Y
V
D
S
----
K
-
L
K
P
-
A
-
F
LQTEG
D
L
F
V
Y
NKHIERLR
N
L
E
G
V
------
R
S
R
K
I
P
F
W
T
-
D
-
E
---
N
F
A
T
-----------
E
K
E
L
I
V
---
R
G
K
K
Y
T
L
PGNYP
Y
Q
M
R
E
N
I
L
A
V
S
V
---
L
-
Y
M
E
M
F
N
E
-
L
---------
E
---
S
F
L
E
---
L
L
R
----------
D
F
--------------
K
P
L
P
H
R
M
E
Y
L
G
Q
I
D
G
R
H
F
Y
N
DSKA
T
S
---
T
H
A
V
L
G
A
L
S
N
F
--------
D
------
K
V
V
L
I
M
C
G
-
I
G
K
K
E
N
Y
S
L
--------
F
V
E
K
-----
A
S
P
K
------
L
K
--
H
L
-
I
M
-
F
G
E
I
S
K
E
--
L
--
A
P
F
V
G
K
IP
H
S
I
V
E
N
M
E
E
A
F
E
---
K
A
M
E
---------
V
---------------
S
E
-------
K
G
D
---
V
I
L
-
L
S
P
G
-
G
----
A
S
-------------
F
-----
A
K
R
G
E
H
F
R
E
I
F
K
R
H
GGD----------------------------------
23
Fugue
69.30
18%
-181
- C2 -
4IND
5
?
A:
[6-383]
---------------
L
G
Q
S
F
P
A
N
A
K
V
K
Y
------
Y
Y
K
L
S
E
K
Q
D
-------
L
----
D
A
F
V
N
S
I
F
V
G
S
Y
K
L
K
Q
-
I
S
Y
-------
L
L
Y
G
-
N
----------------
T
K
I
V
S
-
A
P
V
V
P
----
L
G
P
N
A
S
-
I
I
I
D
D
E
L
----
Q
--
E
G
L
-------
Y
L
I
R
I
-
K
V
--------
Y
N
------
T
-------
N
-
S
F
-
S
V
T
V
--
T
------
P
F
F
NNNNT
M
T
Y
S
I
-----
G
A
N
----
S
E
-
F
E
I
---------
Y
D
--
I
F
T
K
E
Q
G
N
I
Y
Y
------
I
Q
L
P
----
P
G
-
L
-------------------
A
I
L
E
F
-
S
L
---
E
R
V
---------
F
EKGN
R
I
N
I
P
K
I
I
H
T
S
G
----
N
-
G
Y
I
-
S
-
F
------------------
R
L
R
K
G
------
T
Y
A
I
K
M
P
Y
S
-
Y
-
N
NTT
S
T
T
F
-----------
T
N
F
Q
F
G
---
T
---------------
I
S
T
S
A
T
I
P
---
L
-
V
-
I
-
S
S
I
-
P
AN
G
S
G
S
G
T
F
L
---
V
Y
L
K
---
I
T
G
----------
D
Y
E
D
V
K
F
S
VTYGGGLG
V
P
F
T
F
G
-
L
E
V
E
E
I
N
--
E
L
V
-----
E
N
---
T
N
F
V
T
Q
S
V
T
L
S
--------
G
------
S
Q
V
T
Q
--
S
-
I
L
N
V
Q
G
S
G
S
--------
H
L
R
L
-----
K
Y
A
S
V
----
S
G
L
--
T
T
-
A
--
V
T
Q
C
Q
L
Q
--
A
--
T
N
L
N
R
S
----------
T
T
Y
S
---
T
V
-
W
DFIAGGSST
P
---------------
P
S
W
D
I
R
EIN
S
-----
I
Q
L
-
V
A
N
G
-
G
S
ST
S
S
V
-------------
T
-----
I
T
L
I
L
V
Y
E
Q
I
A
G
E
L
S
H
H----------------------------------
17
Fugue
67.33
19%
-162
- C1 -
4CIJ
-
?
A:
[3-269]
----------------
M
S
G
L
K
P
C
V
D
W
L
Q
------
V
T
-
F
K
T
G
Q
D
SV
K
K
C
V
E
K
----
L
E
K
V
F
E
I
L
----
G
L
N
E
-
A
E
F
-------
L
P
L
K
-
N
----------------
G
K
Y
G
Y
K
Q
G
V
A
F
----
Q
G
--------
N
P
V
L
A
V
Y
Y
D
--
G
A
D
DM
G
I
H
V
E
M
T
G
Q
G
-
C
R
--------
L
F
------
E
-------
L
-
H
T
-
S
I
N
W
--
Y
------
E
L
F
-------
Y
R
L
-----
V
Y
E
Y
E
V
N
I
T
-
R
L
D
---------
V
A
--
V
D
D
F
K
G
----
Y
------
F
K
------------------------------------
I
---
N
T
L
---------
V
----------
K
K
L
K
D
D
----
E
-
V
T
S
-
R
-
F
------------------
K
K
A
R
H
------
I
E
N
I
V
I
E
G
--------
G
E
T
I
-----------
G
H
T
L
Y
F
---
G
---------------
A
P
S
------------------
S
---------
D
---
I
Q
V
R
---
F
Y
E
----------
K
N
--------------
V
Q
M
G
M
D
-
I
D
V
W
N
R
T
E
I
Q
L
R
-------------------------------------------
D
-
D
R
A
H
V
V
A
Q
I
--------
I
A
D
D
-----
V
L
P
--------------------
L
G
E
I
--
V
--
A
G
L
L
R
N
----------
Y
I
Q
F
---
R
T
-
R
---------
K
---------------
A
T
-------
D
-----
K
N
K
-
K
R
W
P
L
A
----
R
F
-------------
W
-----
L
N
F
L
G
D
V
Q
P
L
RIAKQM-----------------------------------
20
Fugue
65.96
17%
-124
- C3 -
4CRU
1
RCD1_HUMAN
B:
[4-273]
-------------
M
L
E
R
E
K
I
Y
Q
W
I
N
E
L
S
------
S
P
-
E
T
R
E
N
A
-------
L
----
L
E
L
S
K
K
R
E
----
S
V
P
D
---
L
-------
A
P
M
L
-
W
----------------
H
S
F
G
T
-
I
A
A
L
L
----
Q
E
I
V
N
I
Y
P
S
I
N
P
P
--
T
L
T
A
--
H
Q
S
-------
N
R
V
C
N
-
A
L
--------
A
L
------
L
-------
Q
-
C
V
-
A
S
H
P
--
E
------
T
R
S
-------
A
F
L
-----
A
A
H
----
I
P
-
L
F
L
---------
Y
P
--
F
L
H
T
V
S
----
K
T
R
P
F
E
Y
L
R
-
L
----
T
S
-
L
-------------------
G
V
I
G
A
-
L
V
---
K
T
D
---------
E
----------
Q
E
V
I
N
F
----
L
-
L
T
T
E
I
-
I
------------------
P
L
C
L
R
------
I
M
E
S
G
S
E
L
S
-
K
-
T
---
V
A
T
F
-----------
I
L
Q
K
I
L
---
L
-----------------------------------------------------------
D
----------
D
T
--------------
G
L
A
Y
I
C
-
Q
T
Y
E
R
F
S
H
V
A
M
I
-----
L
G
---
K
M
V
L
Q
L
S
K
E
P
S
----------------------
A
-
R
L
L
K
H
V
V
R
C
--------
Y
L
R
L
-----
S
D
N
P
R
----
A
R
E
--
A
L
-
R
--
Q
C
-----------------------------
L
---
P
D
-
Q
---------
L
---------------
K
D
-------
T
-----
T
F
A
-
Q
V
L
K
-
D
----
D
T
-------------
T
-----
T
K
R
W
L
A
Q
L
V
K
N
L
Q
E-------------------------------------
24
Fugue
64.89
17%
-148
- C4 -
4PCH
2
?
A:
[8-271]
-------------
E
V
L
D
T
V
--------------------
P
L
T
E
-------
D
----
T
Q
Y
K
V
E
A
V
----
L
L
P
N
-------------
F
G
-
K
----------------
A
A
F
Q
S
-
R
G
L
-------------
P
Y
T
M
S
D
T
L
G
P
G
A
--
A
L
C
-------
Y
S
V
A
V
-
I
N
--------
L
P
------
E
-------
I
-
M
I
-
V
W
E
A
--
Y
------
R
L
E
-------
T
E
L
-----
L
F
A
----
P
Q
-
M
A
S
---------
S
G
--
Y
Q
R
A
N
G
----
T
------
L
--------------------------------
A
G
I
-
E
G
---
T
Q
L
---------
Y
----------
F
W
A
C
G
G
G
P
L
D
V
-
I
G
I
-
N
-
P
------------------
D
P
E
R
L
------
K
V
N
E
A
L
E
G
P
-
G
-
N
---
S
D
V
A
-----------
S
L
Q
A
L
R
---
K
---------------
Q
V
N
A
A
N
F
P
---
V
E
L
-
W
-
V
A
D
-
P
---------
T
---
K
N
D
N
---
T
R
Y
----------
F
G
--------------
R
V
V
G
G
G
-
V
T
P
P
V
V
S
Y
G
N
Q
S
-----
T
T
---
P
L
I
D
E
N
G
V
G
I
L
--------
C
------
T
F
G
S
V
--
Y
-
L
T
S
A
D
M
V
----------------------------------------
G
M
T
G
L
P
--
G
--
L
P
T
L
S
A
----------
D
Y
S
N
---
Q
R
-
T
---------
V
---------------
Q
A
-------
G
-----------
Y
G
-------
R
-------------
F
-----
F
R
V
H
C
R
Q
R
R
I
-----------------------------------------
22
Fugue
59.55
18%
-124
- C6 -
1XIP
-
NU159_YEAST
A:
[1-381]
A
S
S
L
K
D
E
V
P
T
E
TS
E
D
F
G
F
K
F
L
G
Q
K
Q
I
L
P
----------
S
F
N
E
K
-------
L
----
P
F
A
S
L
Q
N
L
----
D
I
S
N
S
K
S
L
-------
F
V
A
A
-
S
----------------
G
S
K
A
V
-
V
G
E
-
L
----
Q
L
L
R
D
H
-
I
T
S
D
S
T
P
L
T
F
K
W
--
E
K
E
-------
I
P
D
V
I
-
F
V
--------
C
F
------
H
GD
Q
V
L
V
S
T
-
R
N
-
A
L
Y
S
--
L
------
D
L
E
-------
E
L
S
-----
E
F
R
----
T
V
-
T
S
F
E--------
K
P
--
V
F
Q
L
K
N
-----------
V
N
-
N
----
T
L
-
V
-------------------
I
L
N
S
V
N
D
L
---
S
A
L
D
LRTK
S
T
K
Q
L
----------
A
Q
N
V
T
S
----
F
-
D
V
T
-
N
-
S
------------------
Q
L
A
V
L
L
KDR
S
F
Q
S
F
A
W
R
N
G
E
M
E
-
K
---
Q
F
E
F
S
L
P
SELEELPV
E
E
Y
S
P
L
---
S
---------------
V
T
I
L
S
--
P
---
Q
-
D
-
F
-
L
A
V
-
F
---------
G
---
N
V
I
S
---
E
T
D
----------
D
E
--------------
V
S
Y
D
Q
K
M
Y
I
I
K
H
I
D
G
S
A
S
F
-----
Q
E
---
T
F
D
I
T
P
P
F
G
Q
I
--------
V
RF
P
Y
M
Y
K
V
T
L
S
--
G
-
L
I
E
P
D
A
N
V
N
--------
V
L
A
S
-----
S
C
S
S
E
----
V
-----
S
-
I
--
W
D
S
K
Q
V
I
--
E
--
P
S
Q
D
S
E
----------
R
A
V
L
---
P
I
-
S
EETD
K
D
T
--
N
---------------
P
I
-------
G
-----
V
A
V
D
V
V
T
S
-
G
----
L
P
-------------
L
-----
V
Y
I
L
N
N
E
G
S
L
Q
I
V
G
L
F
H----------------------------------
19
Fugue
56.61
16%
-165
- C6 -
3BWS
2
?
A:
[27-433]
-----------G
T
E
I
V
K
F
S
I
H
P
Y
K
G
T
V
I
------
R
L
-
G
E
E
I
L
P
-------
F
----
K
V
L
E
M
D
-----------
K
N
I
-------
A
L
V
E
M
A
----------------
I
P
V
Y
K
-
D
E
K
E
I
----
E
L
K
L
S
S
-
P
G
F
Q
N
S
S
Y
R
I
R
K
--
P
E
E
-------
L
N
E
K
L
-
I
A
L
D
K
E
GIT
H
R
F
------
I
-------
S
-
R
F
-
K
T
G
F
--
Q
------
P
K
S
-------
V
R
F
-----
I
D
N
----
T
R
-
L
A
I
P
L
LEDE
G
M
D
V
L
--
D
I
N
S
G
Q
----
T
------
V
R
-
L
----
S
P
-
P
-------------------
E
K
Y
K
K
-
K
L
GF
V
E
T
I
---------
S
----------
I
P
E
H
N
E
----
L
-
W
V
S
-
Q
M
Q
------------------------------
A
N
A
V
H
V
F
D
-
L
-
K
---
T
L
A
Y
-----------
K
A
T
V
D
L
TGK
W
---------------
S
K
I
L
L
Y
D
P
IRD
L
-
V
-
Y
-
C
S
N
W
I
---------
S
---
E
D
I
S
---
V
I
D
RKTKLEI
R
K
T
D
K
--------------
I
G
L
P
R
G
-
L
L
L
S
K
D
G
K
-
E
L
Y
-----
I
A
---
Q
F
S
A
S
N
Q
E
S
G
G
--------
G
------
R
L
G
I
Y
--
S
M
D
K
E
K
L
I
D
T
I
G
P
PGNK
R
H
I
V
S
G
-----
N
T
E
N
K
----
I
Y
V
--
S
D
M
C
--
C
S
K
I
E
V
Y
DL
K
--
E
K
K
V
Q
K
----------
S
I
P
V
F
D
K
P
N
-
T
---------
I
---------------
A
L
-------
S
PDGK
Y
L
Y
V
-
S
C
R
G
-
P
----
N
H
PTEGYLKKGL
V
L
G
K
-----
V
Y
V
I
D
T
T
T
D
T
VK
E
F
W
E
A
G
NQP
T
G
L
D
V
S
PDNR
Y
L
V
I
S
DFLDH
Q
I
R
V
Y
R
R
DGF
18
Fugue
55.75
14%
-137
* C4 *
2OH5
5
?
A:
[4-248]
------------A
D
V
A
G
T
S
N
R
D
F
R
G
R
E
Q
------
R
L
-
F
N
S
E
Q
Y
-------
N
----
Y
N
N
S
L
N
--------
G
E
-
V
S
V
-------
W
V
Y
A
-
Y
----------------
Y
S
D
G
S
-
V
L
V
I
N
----
K
N
S
Q
Y
--------
K
V
G
I
S
E
----
T
-------
F
K
A
L
K
-
E
Y
--------
R
K
GQHND
S
Y
-------
D
-
E
Y
-
E
V
N
Q
--
S
------
I
Y
Y
-------
P
N
G
-----
G
D
A
----
R
K
------------------
F
H
S
N
A
----
K
------
P
R
------
A
I
-
Q
-------------------
I
I
F
S
P
-
S
V
---
N
V
R
---------
T
----------
I
K
M
A
K
G
----
N
-
A
V
S
-
V
-
P
------------------
D
E
Y
L
Q
------
R
S
H
P
W
E
A
T
G
-
I
K
Y
---
R
K
I
K
-----------
R
D
G
E
I
V
---
G
---------------
Y
S
H
Y
F
E
L
P
---
H
-
E
-
Y
-
N
S
I
-------------------------------------------------------------------------------------------------------------
S
L
--
A
-
V
S
G
V
H
K
N
P
S
--------
S
Y
N
V
-----
G
S
A
H
N
----
V
M
D
--
V
F
-
Q
--
S
C
D
L
A
L
R
--
F
--
C
N
R
Y
W
A
----------
E
L
E
L
---
V
N
-
H
-----------------------------------------
Y
I
-
S
P
N
A
-
Y
----
P
Y
-------------
L
D
INN
H
S
Y
G
V
A
L
S
N
R
Q
-----------------------------------------
13
HHSearch
24.02
12%
64
- C5 -
1RKL
-
OST4_YEAST
A:
[3-28]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
-----------
E
Q
L
N
S
L
---
A
---------------
I
T
F
G
I
V
M
M
---
T
-
L
-
I
-
V
I
Y
-
H
---------
A
---
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
22.83
16%
133
- C5 -
1JB0
-
PSAM_THEEB
M:
[4-28]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
-----------
T
Q
V
Y
V
A
---
L
---------------
V
I
A
L
L
P
A
V
---
L
-
A
-
F
-
R
L
S
-
T
---------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
20.06
15%
80
- C5 -
2LAT
-
OST4_HUMAN
A:
[3-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
-----------
V
Q
L
A
I
F
---
A
---------------
N
M
L
G
V
S
L
F
---
L
-
L
-
V
-
V
L
Y
-
H
---------
Y
---
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
9.58
28%
433
- C5 -
2B2H
-
?
A:
[243-260]
---------------------------------------------------------------------------------------------------------------------------------
K
P
G
S
L
G
I
V
S
--
G
A
I
-------
A
G
L
A
A
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------