@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2365: (2016-04-03 )
MTKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYSVKNAYNMIAEKEGRLDILINNAGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPLLEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSSKSAVTMLTLQYAKGLPNMQINAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW
Atome Classification :
(20 SA)
.........10-........20.-.....--..30........40-----..--..------.------..-----.50----.........60....-....70-..-.......80.....------...-90.......-----------------------.--100.......110.......120..-.----.-----------...130..--.....140..-..-----.----------.------------.-----------.150.--------------------..-----------------------....160.......170....--.--..------180-........190---.------...--------------.------------------------.-.200........210....--...220.....-..230...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
I
V
L
I
TGGN-KGLG
Y
A
S
A
E
A
L
-
K
ALG
Y
--
K
V
Y
IGSRNDVR
G
Q
Q
-----
A
S
--
Q
K------L------
G
V
-----
H
Y
-----
V
Q
L
D
VTSDY
S
V
K
N
A
Y
-
N
M
I
A
E--KE-G
R
L
D
I
L
I
NNAGISG------QFS-APSKL
T
P
R
D
-----------------------
V
--
E
E
V
Y
Q
T
N
V
F
G
I
V
R
M
M
N
T
F
V
P
L
LEKS-E----Q-----------
P
V
V
V
N
VSS--GLGSFGM-VT-NP-----
E
----------
T
------------
A
-----------
E
S
K
V
N
--------------------
S
L-----------------------AYCSSK
S
A
V
T
M
L
T
L
Q
Y
AKGLP--N--
M
Q
------
I
N--AADPGATNT
D
L
---
V
------
G
DF--------------S------------------------N-N
S
K
-
H
V
S
E
G
I
K
P
I
I
Q
L
A
TI--GADGPTG
T
F
IN-GDGE-MPW
1
PsiBlast_PDB
86.11
26%
-93
- C1 -
3O26
1
?
A:
[13-302]
--
R
C
A
V
V
T
G
G
N
-
K
G
I
G
F
E
I
C
K
Q
L
-
S
S
N
G
I
--
M
V
V
L
T
C
R
D
V
T
K
G
H
E
-----
A
V
--
E
K
------
L
K
N
S
NHE
N
V
-----
V
F
-----
H
Q
L
D
V
T
D
P
I
A
T
M
S
S
L
A
D
F
I
K
T
--
H
F
-
G
K
L
D
I
L
V
N
N
A
G
V
A
G
FSVD
A
D
R
F
K
-
A
M
I
S
D
I
G
E
D
SE
E
L
V
K
I
YEK
P
E
A
Q
E
L
M
S
E
T
Y
E
L
A
--
E
E
C
L
K
I
N
Y
N
G
V
K
S
V
T
E
V
L
I
P
L
L
Q
L
S
-
D
----
S
-----------
P
R
I
V
N
V
S
S
--
S
T
G
S
L
K
Y
-
V
S
-
N
------
E
----------
T
------------
A
L
E
I
L
G
DGDALT
E
E
R
I
D
--------------------
M
V
V
N
M
L
L
K
D
F
K
E
NLIETNGWPSFG
A
A
Y
T
T
S
K
A
C
L
N
A
Y
T
R
V
L
A
N
K
I
P
--
K
--
F
Q
------
V
N
--
C
V
C
P
G
L
V
K
T
E
M
NYG
I
------
G
N
Y
--------------
T
-------------------------------
A
E
E
G
A
E
H
V
V
R
I
A
L
F
--
P
D
D
G
P
S
G
F
F
-----------
47
HHSearch
85.99
27%
-73
- C1 -
2D1Y
1
?
A:
[6-244]
-
G
K
G
V
L
V
T
G
G
A
-
R
G
I
G
R
A
I
A
Q
A
F
-
A
R
E
G
A
--
L
V
A
L
C
D
L
R
P
E
G
K
-
E
-----
V
A
--
E
A
------
I
------
G
G
-----
A
F
-----
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
-
E
E
A
A
Y
--
A
L
-
G
R
V
D
V
L
V
N
N
A
A
I
A
A
------
P
G
S
-
A
-
L
T
V
R
L
P
E
-----------------------
W
--
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
E
M
R
K
V
-
G
----
G
-----------
G
A
I
V
N
V
A
S
--
V
Q
G
L
F
A
E
--------------------------------------------------
Q
E
--------------------
N
A
-----------------------
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
PL
R
--
I
R
------
V
N
--
A
V
A
P
G
A
I
A
T
E
A
---
V
------
L
E
A
I
AR
R
D
W
--------
E
D
LHAL-------------------
R
-
R
L
G
-
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
--
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
-----
5
PsiBlast_PDB
84.98
28%
-76
- C1 -
1WMA
12
CBR1_HUMAN
A:
[6-276]
---
V
A
L
V
T
G
G
N
-
K
G
I
G
L
A
I
V
R
D
L
C
R
L
F
S
G
--
D
V
V
L
T
A
R
D
V
T
R
G
Q
A
-----
A
V
--
Q
Q
------
L
------
Q
A
E
G
L
S
P
R
F
-----
H
Q
L
D
I
D
D
L
Q
S
I
R
A
L
R
-
D
F
L
R
K
--
E
Y
-
G
G
L
D
V
L
V
N
N
A
G
I
A
F
------
K
V
A
-
D
P
---
T
P
F
H
-----------------------
I
Q
A
E
V
T
M
K
T
N
F
F
G
T
R
D
V
C
T
E
L
L
P
L
I
K
P
-------
Q
-----------
G
R
V
V
N
V
S
S
--
I
M
S
V
R
A
L
-
K
S
C
S
P
-----
E
L
Q
Q
K
F
R
SETI
T
------------
E
-----------
E
E
L
V
G
L
M
N
K
F
V
E
D
T
K
K
GVHQKEGWP
S
S
-----------------------
A
Y
G
V
T
K
I
G
V
T
V
L
S
R
I
H
A
R
K
L
S
--
E
--
Q
R
KGDK
I
L
L
N
--
A
C
C
P
G
W
V
R
T
D
M
---
A
------
G
----------------
P
------------------------
K
-
A
T
K
-
S
P
E
E
G
A
E
T
P
V
Y
L
A
L
L
PP
D
A
E
G
P
H
G
Q
F
V
S
-
E
K
R
V
-
E
Q
W
43
HHSearch
84.42
28%
-66
* C1 *
3WDS
4
?
A:
[12-259]
-
G
R
K
A
I
V
T
G
G
S
-
K
G
I
G
A
A
I
A
R
A
L
-
D
K
A
G
A
--
T
V
A
I
A
D
L
D
V
M
A
A
Q
A
-----
V
V
--
A
G
------
L
EN----
G
G
-----
F
A
-----
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
-
Q
K
A
I
D
--
A
L
-
G
G
F
D
L
L
C
A
N
A
G
V
S
T
------
M
R
P
-
A
-
V
D
I
T
D
E
E
-----------------------
W
--
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
----
K
-----------
G
V
I
V
N
T
A
S
--
L
A
A
K
V
G
A
--------------------------------------------------
P
L
--------------------
L
A
-----------------------
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
PK
N
--
I
R
------
V
N
--
C
V
C
P
G
F
V
K
T
A
M
---
Q
------
E
R
E
I
I
W
E
A
E
L
R
GM----
T
P
E
A
V
R
A
E
Y
V
S
L
TPL----------
G
-
R
I
E
-
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
--
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
-----
8
PsiBlast_PDB
83.73
28%
-78
- C1 -
3BHM
8
CBR1_HUMAN
A:
[6-276]
---
V
A
L
V
T
G
G
N
-
K
G
I
G
L
A
I
V
R
D
L
C
R
L
F
S
G
--
D
V
V
L
T
A
R
D
V
T
R
G
Q
A
-----
A
V
--
Q
Q
------
L
------
Q
A
E
G
L
S
P
R
F
-----
H
Q
L
D
I
D
D
L
Q
S
I
R
A
L
R
-
D
F
L
R
K
--
E
Y
-
G
G
L
D
V
L
V
N
N
A
G
I
A
F
------
K
V
A
-
D
P
---
T
P
F
H
-----------------------
I
Q
A
E
V
T
M
K
T
N
F
F
G
T
R
D
V
C
T
E
L
L
P
L
I
K
P
-------
Q
-----------
G
R
V
V
N
V
S
S
--
I
M
S
V
R
A
L
-
K
S
C
S
P
-----
E
L
Q
Q
K
F
R
SETI
T
------------
E
-----------
E
E
L
V
G
L
M
N
K
F
V
E
D
T
K
K
GVHQKEGWP
S
S
-----------------------
A
Y
G
V
T
K
I
G
V
T
V
L
S
R
I
H
A
R
K
L
S
--
E
--
Q
R
KGDK
I
L
L
N
--
A
C
C
P
G
W
V
R
T
D
M
---
A
------
G
----------------
P
------------------------
K
-
A
T
K
-
S
P
E
E
G
A
E
T
P
V
Y
L
A
L
L
PP
D
A
E
G
P
H
G
Q
F
V
S
-
E
K
R
V
-
E
Q
W
7
PsiBlast_PDB
83.57
28%
-78
- C1 -
3BHJ
13
CBR1_HUMAN
A:
[6-276]
---
V
A
L
V
T
G
G
N
-
K
G
I
G
L
A
I
V
R
D
L
C
R
L
F
S
G
--
D
V
V
L
T
A
R
D
V
T
R
G
Q
A
-----
A
V
--
Q
Q
------
L
------
Q
A
E
G
L
S
P
R
F
-----
H
Q
L
D
I
D
D
L
Q
S
I
R
A
L
R
-
D
F
L
R
K
--
E
Y
-
G
G
L
D
V
L
V
N
N
A
G
I
A
F
------
K
V
A
-
D
P
---
T
P
F
H
-----------------------
I
Q
A
E
V
T
M
K
T
N
F
F
G
T
R
D
V
C
T
E
L
L
P
L
I
K
P
-------
Q
-----------
G
R
V
V
N
V
S
S
--
I
M
S
V
R
A
L
-
K
S
C
S
P
-----
E
L
Q
Q
K
F
R
SETI
T
------------
E
-----------
E
E
L
V
G
L
M
N
K
F
V
E
D
T
K
K
GVHQKEGWP
S
S
-----------------------
A
Y
G
V
T
K
I
G
V
T
V
L
S
R
I
H
A
R
K
L
S
--
E
--
Q
R
KGDK
I
L
L
N
--
A
C
C
P
G
W
V
R
T
D
M
---
A
------
G
----------------
P
------------------------
K
-
A
T
K
-
S
P
E
E
G
A
E
T
P
V
Y
L
A
L
L
PP
D
A
E
G
P
H
G
Q
F
V
S
-
E
K
R
V
-
E
Q
W
6
PsiBlast_PDB
82.36
28%
-77
- C1 -
3BHI
2
CBR1_HUMAN
A:
[6-276]
---
V
A
L
V
T
G
G
N
-
K
G
I
G
L
A
I
V
R
D
L
C
R
L
F
S
G
--
D
V
V
L
T
A
R
D
V
T
R
G
Q
A
-----
A
V
--
Q
Q
------
L
------
Q
A
E
G
L
S
P
R
F
-----
H
Q
L
D
I
D
D
L
Q
S
I
R
A
L
R
-
D
F
L
R
K
--
E
Y
-
G
G
L
D
V
L
V
N
N
A
G
I
A
F
------
K
V
A
-
D
P
---
T
P
F
H
-----------------------
I
Q
A
E
V
T
M
K
T
N
F
F
G
T
R
D
V
C
T
E
L
L
P
L
I
K
P
-------
Q
-----------
G
R
V
V
N
V
S
S
--
I
M
S
V
R
A
L
-
K
S
C
S
P
-----
E
L
Q
Q
K
F
R
SETI
T
------------
E
-----------
E
E
L
V
G
L
M
N
K
F
V
E
D
T
K
K
GVHQKEGWP
S
S
-----------------------
A
Y
G
V
T
K
I
G
V
T
V
L
S
R
I
H
A
R
K
L
S
--
E
--
Q
R
KGDK
I
L
L
N
--
A
C
C
P
G
W
V
R
T
D
M
---
A
------
G
----------------
P
------------------------
K
-
A
T
K
-
S
P
E
E
G
A
E
T
P
V
Y
L
A
L
L
PP
D
A
E
G
P
H
G
Q
F
V
S
-
E
K
R
V
-
E
Q
W
48
HHSearch
81.52
27%
-69
- C1 -
3AWD
1
?
A:
[12-260]
D
N
R
V
A
I
V
T
G
G
A
-
Q
N
I
G
L
A
C
V
T
A
L
-
A
E
A
G
A
--
R
V
I
I
A
D
L
D
E
A
M
A
T
K
-----
A
V
--
E
D
------
L
R
M
E
GH-
D
V
-----
S
S
-----
V
V
M
D
V
T
N
T
E
S
V
Q
N
A
V
-
R
S
V
H
E
--
Q
E
-
G
R
V
D
I
L
V
A
C
A
G
I
C
I
------
S
E
V
-
K
A
E
D
M
T
D
G
Q
-----------------------
W
--
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
Q
-
K
----
Q
-----------
G
V
I
V
A
I
G
S
--
M
S
G
L
I
V
N
-
R
-----------------------------------------------
P
Q
Q
--------------------
Q
A
-----------------------
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
PH
G
--
I
R
------
A
N
--
A
V
A
P
T
Y
I
E
T
T
L
---
T
------
R
F
G
M
E
K
P
E
L
Y
D
A
W
I
A
G
T
P
M-----------------------
G
-
R
V
G
-
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
D
--
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
-
T
V
W
9
PsiBlast_PDB
80.92
32%
-82
- C1 -
4QEC
3
?
A:
[1-215]
M
K
K
N
V
L
I
T
G
G
F
-
K
G
I
G
K
Q
V
A
L
E
F
-
L
K
N
D
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
I
P
H
L
F
S
S
--
Y
E
------
E
------
N
I
-----
S
F
-----
Y
Q
L
D
V
T
D
E
E
Q
V
N
E
I
I
-
N
K
I
V
K
--
K
F
-
G
R
L
D
V
L
V
N
N
A
G
I
S
L
------
S
D
G
-
L
L
T
E
T
K
T
T
D
-----------------------
F
--
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
-
S
----
C
-----------
G
A
I
V
N
I
S
S
IT
G
L
S
G
F
P
Y
------------------------------------------------------------------------
S
I
-----------------------
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
--
D
KG
I
K
------
I
N
--
A
V
A
P
G
I
I
K
T
E
T
---
L
Q
K
E
I
D
S
G
E
F
--------------
S
------------------------
E
-
D
S
----
I
S
S
I
H
P
M
Q
K
L
G
T
-----------------------
4
PsiBlast_PDB
79.76
29%
-71
- C1 -
3WXB
2
?
A:
[27-279]
--
R
S
V
L
V
T
G
A
N
-
R
G
I
G
L
G
F
V
Q
H
L
-
L
A
L
S
N
PP
E
W
V
F
A
T
C
R
D
P
K
G
Q
R
-----
A
Q
E
L
Q
K
------
L
------
A
S
-----
K
H
PN
L
V
I
V
P
L
E
V
T
D
P
A
S
I
K
A
A
A
-
A
S
V
G
E
R
L
K
G
-
S
G
L
N
L
L
I
N
N
A
G
I
A
R
------
A
N
T
-
I
D
N
E
-
T
L
K
D
-----------------------
M
--
S
E
V
Y
T
T
N
T
I
A
P
L
L
L
S
Q
A
F
L
P
M
L
K
K
A
-
A
----
Q
E
N
PGSGLSCSK
A
A
I
I
N
I
S
S
--
T
A
G
S
I
Q
D
-
L
Y
-
L
W
-----
Q
----------
Y
------------
G
-----------
Q
------------------------
A
L
-----------------------
S
Y
R
C
S
K
A
A
L
N
M
L
T
R
C
Q
S
M
G
Y
R
--
E
--
H
G
------
I
F
C
V
A
L
H
P
G
W
V
K
T
D
M
---
G
------
G
T
L
--------------
E
------------------------
D
-
K
S
R
V
T
V
D
E
S
V
G
G
M
L
K
V
L
S
N
--
L
S
E
K
D
S
G
A
F
L
N
-
W
E
G
K
V
M
A
W
22
PsiBlast_CBE
79.55
32%
-81
- C1 -
4QEC
3
?
B:
[1-215]
M
K
K
N
V
L
I
T
G
G
F
-
K
G
I
G
K
Q
V
A
L
E
F
-
L
K
N
D
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
IPHLF
S
S
--
Y
E
------
E
------
N
I
-----
S
F
-----
Y
Q
L
D
V
T
D
E
E
Q
V
N
E
I
I
-
N
K
I
V
K
--
K
F
-
G
R
L
D
V
L
V
N
N
A
G
I
S
L
------
S
D
G
-
L
L
T
E
T
K
T
T
D
-----------------------
F
--
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
-
S
----
C
-----------
G
A
I
V
N
I
S
S
IT
G
L
S
G
F
P
Y
------------------------------------------------------------------------
S
I
-----------------------
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
--
D
KG
I
K
------
I
N
--
A
V
A
P
G
I
I
K
T
E
T
---
L
QKEIDS
G
E
F
--------------
S
------------------------
E
-
D
S
----
I
S
S
I
H
P
M
Q
K
L
G
T
-----------------------
10
PsiBlast_PDB
79.40
31%
-82
- C1 -
4QED
2
?
A:
[1-215]
M
K
K
N
V
L
I
T
G
G
F
-
K
G
I
G
K
Q
V
A
L
E
F
-
L
K
N
D
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
I
P
H
L
F
S
S
--
Y
E
------
E
------
N
I
-----
S
F
-----
Y
Q
L
D
V
T
D
E
E
Q
V
N
E
I
I
-
N
K
I
V
K
--
K
F
-
G
R
L
D
V
L
V
N
N
A
G
I
S
L
------
S
D
G
-
L
L
T
E
T
K
T
T
D
-----------------------
F
--
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
-
S
----
C
-----------
G
A
I
V
N
I
S
S
IT
G
L
S
G
F
P
Y
------------------------------------------------------------------------
S
I
-----------------------
L
F
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
--
D
KG
I
K
------
I
N
--
A
V
A
P
G
I
I
K
T
E
T
---
L
Q
K
E
I
D
S
G
E
F
--------------
S
------------------------
E
-
D
S
----
I
S
S
I
H
P
M
Q
K
L
G
T
-----------------------
23
PsiBlast_CBE
78.47
31%
-80
- C1 -
4QED
3
?
B:
[1-215]
M
K
K
N
V
L
I
T
G
G
F
-
K
G
I
G
K
Q
V
A
L
E
F
-
L
K
N
D
Y
--
H
V
C
I
T
S
R
Y
F
E
K
E
K
R
IPHLF
S
S
--
Y
E
------
E
------
N
I
-----
S
F
-----
Y
Q
L
D
V
T
D
E
E
Q
V
N
E
I
I
-
N
K
I
V
K
--
K
F
-
G
R
L
D
V
L
V
N
N
A
G
I
S
L
------
S
D
G
-
L
L
T
E
T
K
T
T
D
-----------------------
F
--
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
M
Q
K
V
-
S
----
C
-----------
G
A
I
V
N
I
S
S
IT
G
L
S
G
F
P
Y
------------------------------------------------------------------------
S
I
-----------------------
L
F
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
--
D
KG
I
K
------
I
N
--
A
V
A
P
G
I
I
K
T
E
T
---
L
QKEIDS
G
E
F
--------------
S
------------------------
E
-
D
S
----
I
S
S
I
H
P
M
Q
K
L
G
T
-----------------------
36
HHSearch
77.70
26%
-75
- C1 -
3O38
-
?
A:
[22-264]
-
G
K
V
V
L
V
T
A
A
A
G
T
G
I
G
S
T
T
A
R
R
A
-
L
L
E
G
A
--
D
V
V
I
S
D
Y
H
E
R
R
L
G
E
-----
T
R
--
D
Q
L
A
D
LGL
G
------
R
V
-----
E
A
-----
V
V
C
D
V
T
S
T
E
A
V
D
A
L
I
-
T
Q
T
V
E
--
K
A
-
G
R
L
D
V
L
V
N
N
A
G
L
G
G
------
Q
T
P
--
V
V
D
M
T
D
E
E
-----------------------
W
--
D
R
V
L
N
V
T
L
T
S
V
M
R
A
T
R
A
A
L
R
Y
F
R
G
V
D
H
----
G
-----------
G
V
I
V
N
N
A
S
--
V
L
G
W
R
A
Q
--------------------------------------------------
H
S
--------------------
Q
S
-----------------------
H
Y
A
A
A
K
A
G
V
M
A
L
T
R
C
S
A
I
E
A
V
EF
G
--
V
R
------
I
N
--
A
V
S
P
S
I
A
R
H
------------------------------DEA---------------------
F
G
R
A
A
-
E
P
W
E
V
A
A
T
I
A
F
L
A
S
D
--
Y
S
S
Y
M
T
G
E
V
V
S
V
S
S
Q
-----
52
HHSearch
76.48
29%
-72
- C1 -
1FJH
-
DIDH_COMTE
A:
[1-247]
-
M
S
I
I
V
I
S
G
C
A
-
T
G
I
G
A
A
T
R
K
V
L
-
E
A
A
G
H
--
Q
I
V
G
I
D
I
R
D
A
E
-----------------------------------------
V
I
A
D
L
S
T
A
E
G
R
K
Q
A
I
-
A
D
V
L
A
--
K
C
S
K
G
M
D
G
L
V
L
C
A
G
L
G
P
------
Q
---------
T
K
V
-----------------------
L
--
G
N
V
V
S
V
N
Y
F
G
A
T
E
L
M
D
A
F
L
P
A
L
K
K
G
-
H
----
Q
-----------
P
A
A
V
V
I
S
S
--
V
A
S
A
H
L
A
-
F
D
K
N
P
L
A
L
A
L
E
----------
A
GE
E
A
K
A
R
A
I
V
E
H
A
-----------
G
E
Q
G
G
--------------------
N
L
-----------------------
A
Y
A
G
S
K
N
A
L
T
V
A
V
R
K
R
A
A
A
W
G
E
A
G
--
V
R
------
L
N
--
T
I
A
P
G
A
---------------------------------FVPPM-------------------
G
-
R
R
A
-
E
P
S
E
M
A
S
V
I
A
F
L
M
S
P
--
A
A
S
Y
V
H
G
A
Q
I
V
I
D
G
G
-----
34
HHSearch
74.74
25%
-73
- C1 -
3TZQ
1
?
B:
[10-250]
E
N
K
V
A
I
I
T
G
A
C
-
G
G
I
G
L
E
T
S
R
V
L
-
A
R
A
G
A
--
R
V
V
L
A
D
L
P
E
T
D
L
A
G
-----
A
A
--
A
S
------
V
GR----
G
A
-----
V
H
-----
H
V
V
D
L
T
N
E
V
S
V
R
A
L
I
-
D
F
T
I
D
--
T
F
-
G
R
L
D
I
V
D
N
N
A
A
H
S
D
------
P
A
D
M
L
V
T
Q
M
T
V
D
V
-----------------------
W
--
D
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
A
-
G
----
G
-----------
G
A
I
V
N
I
S
S
--
A
T
A
H
A
A
Y
--------------------------------------------------
D
M
--------------------
S
T
-----------------------
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
RH
G
--
V
R
------
C
N
--
A
I
A
P
G
L
V
R
T
P
R
---
L
------
E
----------------
P
Q
P
I
V
D
I
F
A
T
H
HL------------
A
G
R
I
G
-
E
P
H
E
I
A
E
L
V
C
F
L
A
S
D
--
R
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
----
11
PsiBlast_PDB
73.96
26%
-57
- C1 -
1N5D
2
CBR1_PIG
A:
[4-276]
-
T
R
V
A
L
V
T
G
A
N
-
K
G
I
G
F
A
I
V
R
D
L
C
R
Q
F
A
G
--
D
V
V
L
T
A
R
D
V
A
R
G
Q
A
-----
A
V
--
K
Q
------
L
------
Q
A
E
G
L
S
P
R
F
-----
H
Q
L
D
I
I
D
L
Q
S
I
R
A
L
C
-
D
F
L
R
K
--
E
Y
-
G
G
L
D
V
L
V
N
N
A
A
I
A
F
------
Q
L
D
-
N
P
T
P
F
H
I
Q
------------------------
A
--
E
L
T
M
K
T
N
F
M
G
T
R
N
V
C
T
E
L
L
P
L
I
K
P
-------
Q
-----------
G
R
V
V
N
V
S
S
--
T
E
G
V
R
A
L
N
E
C
-
S
P
-----
E
L
Q
Q
K
F
K
SETI
T
------------
E
-----------
E
E
L
V
G
--------------------
L
M
N
K
F
V
E
D
T
K
N
GVHRKEGWSDS---
T
Y
G
V
T
K
I
G
V
S
V
L
S
R
I
Y
A
R
K
L
R
--
E
--
Q
R
AGDK
I
L
L
N
--
A
C
C
P
G
W
V
R
T
D
M
---
G
------
G
P
K
--------------
A
------------------------
P
-
K
S
P
-
E
V
G
A
E
T
P
V
Y
L
A
L
L
P
S
--
D
A
E
G
P
H
G
Q
F
V
T
-
D
K
K
V
-
V
E
W
41
HHSearch
73.67
27%
-65
- C1 -
3VTZ
-
?
A:
[5-245]
T
D
K
V
A
I
V
T
G
G
S
-
S
G
I
G
L
A
V
V
D
A
L
-
V
R
Y
G
A
--
K
V
V
S
V
S
L
D
E
--
D
V
N
------------------------
V
S
-----
D
H
-----
F
K
I
D
V
T
N
E
E
E
V
K
E
A
V
-
E
K
T
T
K
--
K
Y
-
G
R
I
D
I
L
V
N
N
A
G
I
E
Q
------
Y
S
P
-
L
-
H
L
T
P
T
E
I
-----------------------
W
--
R
R
I
I
D
V
N
V
N
G
S
Y
L
M
A
K
Y
T
I
P
V
M
L
A
I
-
G
----
H
-----------
G
S
I
I
N
I
A
S
--
V
Q
S
Y
A
A
T
--------------------------------------------------
K
N
--------------------
A
A
-----------------------
A
Y
V
T
S
K
H
A
L
L
G
L
T
R
S
V
A
I
D
Y
A
P-
K
--
I
R
------
C
N
--
A
V
C
P
G
T
I
M
T
P
M
---
V
------
I
K
A
--------------
A
K
M
E
VGEDEN
A
V
E
R
K
I
E
E
W
G
R
Q
H
P
M
G
-
R
I
G
-
R
P
E
E
V
A
E
V
V
A
F
L
A
S
D
--
R
S
S
F
I
T
G
A
C
L
T
V
D
G
G
L
----
40
HHSearch
71.82
25%
-74
- C1 -
3N74
-
?
A:
[5-249]
-
G
K
V
A
L
I
T
G
A
G
-
S
G
F
G
E
G
M
A
K
R
F
-
A
K
G
G
A
--
K
V
V
I
V
D
R
D
K
A
G
A
E
R
-----
V
A
--
G
E
------
I
GD----
A
A
-----
L
A
-----
V
A
A
D
I
S
K
E
A
D
V
D
A
A
V
-
E
A
A
L
S
--
K
F
-
G
K
V
D
I
L
V
N
N
A
G
I
G
H
------
K
P
Q
-
N
A
E
L
V
E
P
E
E
-----------------------
F
--
D
R
I
V
G
V
N
V
R
G
V
Y
L
M
T
S
K
L
I
P
H
F
K
E
N
-
G
A
K
G
Q
E
-----------
C
V
I
L
N
V
A
S
--
T
G
A
G
R
P
R
--------------------------------------------------
P
N
--------------------
L
A
-----------------------
W
Y
N
A
T
K
G
W
V
V
S
V
T
K
A
L
A
I
E
L
A
PA
K
--
I
R
------
V
V
--
A
L
N
P
V
----------------------------------IPM---------------------
G
-
R
L
L
-
K
P
D
D
L
A
E
A
A
A
F
L
C
S
P
--
Q
A
S
M
I
T
G
V
A
L
D
V
D
G
G
-----
45
HHSearch
71.78
22%
-72
- C1 -
3GAF
-
?
A:
[11-250]
-
D
A
V
A
I
V
T
G
A
A
-
A
G
I
G
R
A
I
A
G
T
F
-
A
K
A
G
A
--
S
V
V
V
T
D
L
K
S
E
G
A
E
A
-----
V
A
--
A
A
------
I
R
Q
A
G
G
-
K
A
-----
I
G
-----
L
E
C
N
V
T
D
E
Q
H
R
E
A
V
I
-
K
A
A
L
D
--
Q
F
-
G
K
I
T
V
L
V
N
N
A
G
G
G
G
------
P
K
P
---
F
D
M
P
M
S
D
-----------------------
F
--
E
W
A
F
K
L
N
L
F
S
L
F
R
L
S
Q
L
A
A
P
H
M
Q
K
A
-
G
----
G
-----------
G
A
I
L
N
I
S
S
--
M
A
G
E
N
T
N
--------------------------------------------------
V
R
--------------------
M
A
-----------------------
S
Y
G
S
S
K
A
A
V
N
H
L
T
R
N
I
A
F
D
V
G
PM
G
--
I
R
------
V
N
--
A
I
A
P
G
A
I
K
T
D
A
---
L
------
A
T
V
LT
P
-----------
E
I
E
R
A
M
L
K
HTPL-------------
G
-
R
L
G
-
E
A
Q
D
I
A
N
A
A
L
F
L
C
S
P
--
A
A
A
W
I
S
G
Q
V
L
T
V
S
G
G
G
----