@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0188: (2015-12-13 )
MEFYASLKSIAMHVPSERVKNAEFQQFLDTSDEWIEKRTGIKERRFANDEEKSSDLGVIAAKQAIERAHLTPQDIDLVVVATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIYLLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILFGDGAGACVIGRTKRLKESVLDVQISANGNFSNYLYTPRTLKPTPFNAKEEALEPFLRMKGNEVFKLAVKTLLKDVETILEKNALKPEDVRLFIPHQANFRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMCEAYEEGRLKKGDLMLLDAFGGGLTWGSALVYFGGI
Atome Classification :
(37 SA)
.........10........20......-..30........40........50.---.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.-......180......--------.190.......200.......210.......220.......230.......240.......250.......260.......270.....-.-.-280.......290.......--300.....--..310.......320........330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
F
Y
A
S
L
K
S
I
A
M
HV
P
S
E
R
VK
N
A
E
F
Q
Q
F
-LDT
S
D
E
W
I
E
K
RTGIKERRFANDEEK---SSDL
G
V
I
A
A
K
Q
A
I
E
R
AHLTPQD
I
D
L
V
V
V
A
TLSPDFLAMPS
T
A
C
V
L
S
A
KLGIENKPAF
D
I
S
A
A
C
T
G
F
I
Y
L
L
S
V
A
K
A
Y
V
ESGMYE
N
V
L
I
V
GAEKTSSVLDFKDR
G
T
C
I
L
FGDGA
G
A
C
V
IG
R
T
K
-
R
L
K
ES
V
L
D
V
Q
I
SANG--------NFSNYLYTPRTLKPTPFN
A
K
E
E
A
L
E
P
F
L
R
MKG
N
E
V
F
K
L
A
V
K
T
L
L
K
D
V
E
T
I
L
E
KNAL
K
P
E
D
V
R
L
FIPHQA
N
F
R
I
I
Q
A
V
R
E
HLDFKD
E
Q
V
V
-
L
-
T
-
V
HKYGNTSAAS
I
P
M
A
M
C
E
A
Y
--
E
EGRLKKG--
D
L
M
L
L
DAFGGGLTW-G
S
A
L
V
YFGGI
14
PsiBlast_PDB
93.86
43%
-97
- C2 -
3IL9
-
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
-
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
5
PsiBlast_PDB
93.61
42%
-104
- C2 -
4YLT
-
FABH_YERPE
A:
[1-316]
--
M
Y
T
K
I
L
G
T
G
S
Y
L
P
V
Q
V
R
S
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
R
I
A
G
L
D
E
T
---
V
A
T
M
G
F
Q
A
A
E
K
A
L
E
M
A
G
I
D
K
D
D
I
G
L
I
I
V
A
T
T
S
S
S
H
-
A
F
P
S
S
A
C
Q
V
Q
R
M
L
G
I
K
D
A
A
S
F
D
L
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
H
A
I
V
I
G
S
D
V
L
S
R
A
L
D
P
E
D
R
G
T
I
I
L
F
G
D
G
A
G
A
V
V
L
G
A
S
E
---
Q
P
G
I
M
S
T
H
L
H
A
D
G
--------
R
Y
G
E
L
L
-------
A
L
P
Y
P
------
P
A
Y
V
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
Q
V
N
N
L
D
R
T
A
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
G
M
D
K
V
V
-
I
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
S
A
F
D
E
A
V
--
R
D
G
R
I
Q
R
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
11
PsiBlast_PDB
93.24
43%
-104
- C2 -
2EFT
3
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
12
PsiBlast_PDB
93.05
43%
-104
- C2 -
2GYO
3
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
72
HHSearch
92.99
44%
-104
- C2 -
1HNJ
2
FABH_ECOLI
A:
[2-317]
---
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
-
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
-
E
--
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
------
N
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
23
PsiBlast_CBE
92.88
43%
-100
- C2 -
1HN9
1
FABH_ECOLI
B:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
82
HHSearch
92.56
47%
-108
- C2 -
2EBD
-
FABH_AQUAE
A:
[2-309]
---
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
-
K
E
E
T
---
I
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
-
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
-
D
-
K
S
D
I
L
A
T
R
M
Y
A
E
G
--------
S
L
E
E
L
L
H
A
D
N
C
--------------
G
Y
I
R
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
P
K
E
K
V
F
-
V
-
N
-
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
--
K
E
G
K
V
K
R
G
--
D
L
I
L
M
T
A
M
G
G
G
L
T
W
-
G
A
V
L
L
R
Y
---
98
Fugue
92.48
44%
-107
- C2 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V-
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
---NET
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
-
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-E--
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
---
A
D
R
V
N
P
E
-
N
--
S
I
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
-
V
V
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
21
PsiBlast_CBE
92.41
43%
-101
- C2 -
2GYO
3
FABH_ECOLI
B:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
15
PsiBlast_PDB
92.32
43%
-100
- C2 -
1EBL
1
FABH_ECOLI
A:
[2-317]
---
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
N
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
9
PsiBlast_PDB
92.28
43%
-102
- C2 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
22
PsiBlast_CBE
92.18
43%
-102
- C2 -
2EFT
4
FABH_ECOLI
B:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
7
PsiBlast_PDB
92.15
43%
-101
- C2 -
1HN9
1
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
34
PsiBlast_CBE
92.01
38%
-100
- C2 -
4X9K
3
FABH2_VIBCH
A:
[3-325]
-
Q
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
--
V
N
---
T
S
D
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
-
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
-
Q
-
K
V
G
L
Q
D
A
Q
I
G
C
D
A
--------
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
N
G
Y
W
A
F
-
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
-
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
--
E
Q
G
K
I
K
P
H
--
D
D
L
L
V
A
A
F
G
A
G
L
T
W
-
G
A
G
H
I
R
W
G
E
R
8
PsiBlast_PDB
91.99
43%
-101
- C2 -
1HND
1
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
-
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
Y
G
E
L
L
T
L
P
N
A
D
R
V
N
P
E
N
S
I
H
------
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
10
PsiBlast_PDB
91.94
43%
-110
- C2 -
1HNK
-
FABH_ECOLI
A:
[1-317]
--
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
---
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
----
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
-------
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
---
E
P
G
I
I
S
T
H
L
H
A
D
G
--------
S
---------------------------------------
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
-
V
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
--
Q
L
V
L
L
E
A
F
---
F
T
W
-
G
S
A
L
V
R
F
---
13
PsiBlast_PDB
91.92
41%
-103
- C2 -
4Z19
2
FABH_YERPE
A:
[1-316]
--
M
Y
T
K
I
L
G
T
G
S
Y
L
P
V
Q
V
R
S
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
R
I
A
G
L
D
E
T
---
V
A
T
M
G
F
Q
A
A
E
K
A
L
E
M
A
G
I
D
K
D
D
I
G
L
I
I
V
A
T
T
S
S
S
H
-
A
F
P
S
S
A
C
Q
V
Q
R
M
L
G
I
K
D
A
A
S
F
D
L
A
A
A
-
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
H
A
I
V
I
G
S
D
V
L
S
R
A
L
D
P
E
D
R
G
T
I
I
L
F
G
D
G
A
G
A
V
V
L
G
A
S
E
---
Q
P
G
I
M
S
T
H
L
H
A
D
G
--------
R
Y
G
E
L
L
-------
A
L
P
Y
P
-------
A
Y
V
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
Q
V
N
N
L
D
R
T
A
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
G
M
D
K
V
V
-
I
-
T
-
L
D
R
H
G
N
T
S
A
A
S
V
P
S
A
F
D
E
A
V
--
R
D
G
R
I
Q
R
G
--
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
-
G
S
A
L
V
R
F
---
1
PsiBlast_PDB
90.81
45%
-108
- C2 -
2EBD
-
FABH_AQUAE
A:
[10-309]
-----------
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
-
E
E
T
---
I
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
-
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
-
D
-
K
S
D
I
L
A
T
R
M
Y
A
E
G
--------
S
L
E
E
L
L
H
A
D
N
C
--------------
G
Y
I
R
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
P
K
E
K
V
F
-
V
-
N
-
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
--
K
E
G
K
V
K
R
G
--
D
L
I
L
M
T
A
M
G
G
G
L
T
W
-
G
A
V
L
L
R
Y
---
20
PsiBlast_PDB
90.56
39%
-97
- C2 -
3IL5
1
FABH_ENTFA
A:
[22-339]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
-
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
---
T
P
H
F
L
N
E
K
L
Q
A
D
G
--------
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
-
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
SQ
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
-
G
S
L
L
L
T
L
---
16
PsiBlast_PDB
90.19
38%
-99
- C2 -
4WZU
1
FABH2_VIBCH
A:
[3-325]
-
Q
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
--
V
N
---
T
S
D
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
-
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
C
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
-
Q
-
K
V
G
L
Q
D
A
Q
I
G
C
D
A
--------
Q
G
R
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
A
D
N
G
Y
W
A
F
-
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
A
Q
D
K
A
F
-
V
-
N
-
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
--
E
Q
G
K
I
K
P
H
--
D
D
L
L
V
A
A
F
G
A
G
L
T
W
-
G
A
G
H
I
R
W
G
E
R
39
PsiBlast_CBE
87.28
35%
-101
- C2 -
2QX1
3
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
41
PsiBlast_CBE
87.07
35%
-98
- C2 -
2QO1
3
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
36
PsiBlast_CBE
86.82
39%
-94
- C2 -
3IL5
1
FABH_ENTFA
C:
[22-339]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
-
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
---
T
P
H
F
L
N
E
K
L
Q
A
D
G
--------
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
-
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
SQ
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
-
G
S
L
L
L
T
L
---
43
PsiBlast_CBE
86.08
35%
-101
- C2 -
2QNZ
3
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
-----
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
44
PsiBlast_CBE
85.93
35%
-98
- C2 -
2QNX
3
FABH_MYCTU
B:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
---
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
54
PsiBlast_CBE
85.79
35%
-96
- C2 -
1U6S
2
FABH_MYCTU
B:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
40
PsiBlast_CBE
85.75
35%
-97
- C2 -
2QO1
3
FABH_MYCTU
B:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
53
PsiBlast_CBE
85.30
35%
-99
- C2 -
2QNY
4
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
----
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
F
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
37
PsiBlast_CBE
85.12
39%
-94
- C2 -
3IL5
1
FABH_ENTFA
B:
[22-339]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
-
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
---
T
P
H
F
L
N
E
K
L
Q
A
D
G
--------
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
-
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
SQ
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
-
G
S
L
L
L
T
L
---
35
PsiBlast_CBE
85.06
39%
-96
- C2 -
3IL5
1
FABH_ENTFA
D:
[22-339]
-
K
N
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
---
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
-
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
---
T
P
H
F
L
N
E
K
L
Q
A
D
G
--------
Q
R
W
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
-----
V
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
-
T
-
N
-
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
SQ
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
-
G
S
L
L
L
T
L
---
55
PsiBlast_CBE
84.46
35%
-98
- C2 -
1U6S
2
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
46
PsiBlast_CBE
84.43
35%
-97
- C2 -
1HZP
2
FABH_MYCTU
B:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
77
HHSearch
84.26
34%
-99
- C2 -
1MZJ
2
FABH_STRLI
A:
[9-333]
-
R
R
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
---
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
-
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
-
V
P
--
G
I
G
P
V
V
R
G
I
D
G
--------
T
G
L
G
S
L
H
M
S
S
S
W
D
Q
Y
V
E
D
--
P
S
V
G
R
P
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
-
S
R
D
-
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
--
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
-
A
G
Q
A
L
L
L
P
D
P
47
PsiBlast_CBE
83.92
35%
-98
- C2 -
1HZP
7
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
45
PsiBlast_CBE
83.89
35%
-99
- C2 -
2QNX
3
FABH_MYCTU
A:
[15-330]
------
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
E
S
---
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
-
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
P
---
F
Q
G
I
G
P
T
V
A
G
S
D
G
--------
E
Q
A
D
A
I
R
--
Q
D
I
D
W
I
T
F
A
Q
N
P
S
G
P
R
P
F
V
R
L
E
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
V
V
-
A
-
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
--
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
-
A
A
Q
V
V
R
M
P
K
-
59
PsiBlast_CBE
78.79
34%
-90
- C2 -
1MZJ
2
FABH_STRLI
A:
[11-330]
---
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
---
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
-
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
-
V
P
G
I
G
P
V
V
R
G
I
D
G
T
G
LGSLHMSS
S
W
D
Q
Y
V
E
D
P
S
V
G
R
P
A
------------
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
S
R
-
D
-
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
--
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
D
P
P
58
PsiBlast_CBE
77.31
34%
-92
- C2 -
1MZJ
2
FABH_STRLI
B:
[11-330]
---
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
---
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
-
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
-
V
P
G
I
G
P
V
V
R
G
I
D
G
T
G
LGS
L
H
M
SS
S
W
D
Q
Y
V
E
D
P
S
V
G
R
P
A
------------
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
S
R
-
D
-
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
--
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
D
P
P