@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0225: (2015-12-13 )
MQEKRLKAIQNKIASWIKEIESGFIDALFSKIGPSKMLRSKLMLALLDEKTDAILLDKALNLCAIVEMIQTASLLHDDVIDKATMRRKLPSINALFGNFNAVMLGDVFYSKAFFELSKMGESIAQALSNAVLRLSRGEIEDVFVGECFNSDKQKYWRILEDKTAHFIEASLKSMAILLNKDAKMYADFGLHFGMAFQIIDDLLDITQDANTLGKPNFSDFKEGKTTLPYLLLYEKLNQHEQGLLISYFKQDSHEIIEWTKEKFKQHGIIEETLKIAQVYSKKALEAIKGENNLILEKLAQDVIYRTF
Atome Classification :
(20 SA)
----------.........10.......--.20--.........30-----------..--.--.....40........50...-.----..--..60........70........80........90........100.......110.......------120----.-.-.......130......-.140.......150.......160.......170.......---180---.......190.......200.......210.......220.......230........240--------.........250--.---------........260.......---270.......280.....----.----.-290--------........300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------M
Q
E
K
R
L
K
A
I
Q
N
K
I
A
S
W
I
K
--
E
I
---
E
S
G
F
I
D
A
L
F
S
K-----------I
G
--
P
--
S
K
M
L
R
S
K
L
M
L
A
L
LDEKT
D
A
I
-
L
----
L
D
--
K
A
L
N
L
C
A
I
V
E
M
I
Q
T
A
S
L
L
H
D
D
V
I
D
K
A
T
M
R
R
KLP
S
I
N
A
L
FGNF
N
A
V
M
L
G
D
V
F
Y
S
K
A
F
F
E
L
S
K
M
------
G
------
E
-
S
-
I
A
Q
A
L
S
N
A
V
L
RLSRGE-IED
V
F
V
G
E
CFNS
D
K
Q
K
Y
W
R
I
L
E
DK
T
A
H
F
I
E
A
S
L
K
S
M
A
I
L
LN---KD
A
---
K
M
Y
A
D
F
G
L
H
F
G
M
A
F
Q
I
I
D
D
L
L
D
I
T
Q
D
A
NTLGKPN
F
S
D
F
KEGKTT
L
P
Y
L
-
L
L
Y
E
K
L
N
Q
HE----------Q
G
L
L
I
S
Y
F
K
Q----D---------
S
H
E
I
I
E
W
T
K
E
K
F
K
QHG
I
I
---
E
E
T
L
K
I
A
Q
V
Y
S
K
K
A
L
E
A
I----K----G-EN---------
N
L
I
L
E
K
L
A
Q
D
V
I
YRTF
1
PsiBlast_PDB
97.51
96%
-120
- C1 -
3TC1
1
?
A:
[1-305]
----------
M
Q
E
K
Q
L
K
A
I
Q
N
K
I
A
S
W
I
K
--
E
I
---
E
S
G
F
I
D
E
L
F
S
K
-----------
I
G
--
P
--
S
K
M
L
R
S
K
L
M
L
A
L
L
N
E
K
T
D
A
I
-
L
----
L
D
--
K
A
L
N
L
C
T
I
V
E
M
I
Q
T
A
S
L
L
H
D
D
V
I
----------------
G
N
F
N
A
V
M
L
G
D
V
F
Y
S
K
A
F
F
E
L
S
K
M
------
G
------
E
-
L
-
I
A
Q
A
L
S
N
A
V
L
R
L
S
R
G
E
-
I
E
D
V
F
V
G
E
C
F
N
S
D
K
Q
K
Y
W
R
I
L
E
D
K
T
A
H
F
I
E
A
S
L
K
S
M
A
I
L
L
N
---
K
D
A
---
K
I
Y
A
D
F
G
L
N
F
G
M
A
F
Q
I
I
D
D
L
L
D
I
T
Q
D
A
K
T
L
G
K
P
N
F
S
D
F
K
E
G
K
T
T
L
P
Y
L
-
L
L
Y
E
K
L
N
Q
H
D
----------
Q
G
L
L
I
S
Y
F
K
Q
----
D
---------
S
H
E
I
I
E
W
T
K
E
K
F
K
Q
Y
G
I
I
---
E
E
T
L
K
T
A
Q
V
Y
S
K
K
A
L
E
A
I
----
K
----
G
-
E
N
---------
N
L
I
L
E
K
L
A
Q
D
V
I
S
R
--
21
PsiBlast_CBE
96.95
96%
-114
- C1 -
3TC1
1
?
B:
[1-305]
----------
M
Q
E
K
Q
L
K
A
I
Q
N
K
I
A
S
W
I
K
--
E
I
---
E
S
G
F
I
D
E
L
F
S
K
-----------
I
G
--
P
--
S
K
M
L
R
S
K
L
M
L
A
L
L
N
E
K
T
D
A
I
-
L
----
L
D
--
K
A
L
N
L
C
T
I
V
E
M
I
Q
T
A
S
L
L
H
D
D
V
I
D
K
A
T
M
R
R
K
L
P
S
I
N
A
L
F
G
N
F
N
A
V
M
L
G
D
V
F
Y
S
K
A
F
F
E
L
S
K
M
------
G
------
E
-
L
-
I
A
Q
A
L
S
N
A
V
L
R
L
S
R
G
E
-
I
E
D
V
F
V
G
E
C
F
N
S
D
K
Q
K
Y
W
R
I
L
E
D
K
T
A
H
F
I
E
A
S
L
K
S
M
A
I
L
L
N
---
K
D
A
---
K
I
Y
A
D
F
G
L
N
F
G
M
A
F
Q
I
I
D
D
L
L
D
I
T
Q
D
A
K
T
L
G
K
P
N
F
S
D
F
K
E
G
K
T
T
L
P
Y
L
-
L
L
Y
E
K
L
N
Q
H
D
----------
Q
G
L
L
I
S
Y
F
K
Q
----
D
---------
S
H
E
I
I
E
W
T
K
E
K
F
K
Q
Y
G
I
I
---
E
E
T
L
K
T
A
Q
V
Y
S
K
K
A
L
E
A
I
----
K
----
G
-
E
N
---------
N
L
I
L
E
K
L
A
Q
D
V
I
S
R
--
69
Fugue
55.43
25%
-94
- C1 -
3OYR
1
?
A:
[20-343]
KSGS
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
--
S
----
D
V
A
I
I
P
A
L
A
E
H
-----------
L
I
--
A
--
A
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
-
D
----
N
D
--
H
F
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
V
V
A
A
---------
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
------
N
S-----
M
-
K
-
A
L
E
I
L
A
R
A
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
VD
V
A
K
S
---
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
-------------------
Y
A
T
L
P
L
L
-
L
A
I
A
R
S
G
P
R
E
----------
A
E
F
W
E
R
A
I
G
T
----
E
---------
A
D
--
F
R
R
A
R
E
L
I
I
G
S
G
A
L
---
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
----
A
MFPA
N
-
D
W
---------
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
39
HHSearch
54.26
26%
-89
* C1 *
1WY0
2
?
A:
[12-341]
------------
K
E
K
A
K
L
I
D
E
K
I
F
E
L
I
P
EK
D
P
---
R
V
L
Y
E
A
A
R
H
Y
P
-----------
L
A
--
G
--
G
K
R
V
R
P
F
V
V
L
T
S
T
E
A
V
G
G
D
-------
P
L
--
R
A
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
R
A
------
E
IP
P
E
K
K
A
-
R
-
V
L
E
V
I
V
K
A
S
N
E
L
C
E
G
Q
-
A
R
D
L
E
F
E
K
K
S
T
V
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
---
D
N
E
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
-
H
F
F
E
N
A
D
E
K
D
----------
K
Q
R
F
L
K
I
F
G
K
-----D--------
I
K
S
D
V
M
E
A
I
D
L
L
K
K
Y
G
S
I
---
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
----
R
----
I
L
P
K
S
K
A
------
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
36
HHSearch
53.65
29%
-93
- C1 -
3APZ
-
SPS3_ARATH
A:
[14-347]
-----------
V
A
D
E
L
S
L
L
S
N
K
L
R
E
M
V
L
A-
E
V
---
P
-----------------------GV
Q
--
G
K
Q
F
R
S
T
I
L
L
L
M
A
T
A
L
D
V
----T
S
E
L
R
V
--
R
Q
R
G
I
A
E
I
T
E
M
I
H
V
A
S
L
L
H
D
D
----------------
V
M
G
N
K
M
S
V
L
A
G
D
F
L
L
S
R
A
C
G
A
L
A
A
L
K-----
N
------
T
-
E
-
V
V
A
L
L
A
T
A
V
E
H
L
V
T
G
E
-
T
M
E
I
T
S
S
T
E
Q
R
Y
S
M
D
Y
Y
M
Q
K
T
Y
Y
K
T
A
S
L
I
S
N
S
C
K
A
V
A
V
L
T
G
---
Q
T
A
E
V
A
V
L
A
F
E
Y
G
R
N
L
G
L
A
F
Q
L
I
D
D
I
L
D
F
T
G
T
S
A
S
L
G
K
G
S
L
S
D
I
R
H
G
V
I
T
A
P
I
L
-
F
A
M
E
E
F
P
Q
---------------
L
R
E
V
V
D
Q
----
V
EK-------
D
P
R
N
V
D
I
A
L
E
Y
L
G
K
S
K
G
I
---
Q
R
A
R
E
L
A
M
E
H
A
N
L
A
A
A
A
I
----
G
----
S
L
P
E
TDN
E
D
V
K
R
S
R
R
A
L
I
D
L
T
H
R
V
I
T
R
N
K
32
HHSearch
53.29
27%
-97
- C1 -
3OYR
1
?
A:
[31-343]
-----------
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S-
D
V
---
A
I
I
P
A
L
A
E
H
L
I
-----------
A
A
--
G
--
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
D
-------
N
D
--
H
F
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
------
N
S-----
M
-
K
-
A
L
E
I
L
A
R
A
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
---
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
-
L
A
I
A
R
S
G
P
R
E
----------
A
E
F
W
E
R
A
I
G
---------------
T
E
A
D
F
R
R
A
R
E
L
I
I
G
S
G
A
L
---
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
----
A
----
M
F
P
A
N
D
W
------
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
67
Fugue
53.06
26%
-89
- C1 -
3AQB
3
HEXB_MICLU
B:
[5-325]
----------
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
--
E
C
I
QS
D
S
E
T
I
N
K
A
A
H
H
-----------
I
L
--
S
--
S
G
G
K
R
V
R
P
M
F
V
L
L
S
G
F
L
N
D
T
-
Q
----
K
D
--
D
L
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
T
I
------
N
N-----
S
-
K
-
F
H
Q
I
F
S
K
T
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
LD
E
Q
S
T
---
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
-
A
A
I
A
N
L
K
E
Q
D
----------
D
D
K
L
E
A
V
V
K
H
LTST
S
---------
D
D
E
V
Y
Q
Y
I
V
S
Q
V
K
Q
Y
G
-
I
---
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
----
S
Q
LQD
S
-
N
I
---------
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
35
HHSearch
50.62
26%
-85
- C1 -
3AQB
3
HEXB_MICLU
B:
[12-325]
-------------
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S-
D
S
---
E
T
I
N
K
A
A
H
H
I
L
-----------
S
S
--
G
--
G
K
R
V
R
P
M
F
V
L
L
S
G
F
L
N
D
T
Q
-------
K
D
--
D
L
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
T
I
------
N
N-----
S
-
K
-
F
H
Q
I
F
S
K
T
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
---
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
-
A
A
I
A
N
L
K
E
Q
D
----------
D
D
K
L
E
A
V
V
K
H
----
L
TSTS-----
D
D
E
V
Y
Q
Y
I
V
S
Q
V
K
Q
Y
G
-
I
---
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
----
S
----
Q
L
Q
D
S
N
I
------
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
38
HHSearch
50.18
24%
-84
- C1 -
3PKO
2
?
A:
[21-333]
-----------
V
E
P
Q
L
T
A
L
Q
D
Y
L
L
R
T
V
Q
L-
D
N
---
Q
P
I
H
H
K
I
L
A
L
L
-----------
K
S
--
G
--
G
K
L
L
R
P
G
Y
F
Y
L
F
S
T
F
G
N
A
A
--
T
----
P
A
--
Q
L
Q
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
S
TT----
D
------
R
-
S
-
L
I
Q
N
H
I
D
A
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
R
E
D
I
T
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
---
A
P
Q
S
V
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
-
L
S
L
S
H
A
P
R
D
--------------
F
H
K
L
L
K
K
----
K
QAM------
T
L
E
D
I
K
H
V
Q
A
L
V
A
Q
Y
D
G
V
---
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
----
Q
----
Q
L
P
V
G
S
A
------
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
6
PsiBlast_PDB
45.30
27%
-88
- C1 -
1WY0
2
?
A:
[58-341]
--------------------------------------------------------------------------------
T
E
A
V
-
G
----
G
D
PL
R
A
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
R
A
EIP
P
E
K
K
------
A
-
R
-
V
L
E
V
I
V
K
A
S
N
E
L
C
E
G
Q
-
A
R
D
L
E
F
E
K
K
S
T
V
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
---
D
N
E
E
Y
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
-
H
F
F
E
N
A
D
E
K
D
K
Q
R
F
L
K
I
FGK------
D
I
K
S
----
D
---------
V
M
E
A
I
D
L
----
L
K
K
Y
G
S
I
---
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
RILP
K
----
S
-
K
A
---------
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
37
HHSearch
45.07
22%
-82
- C1 -
3LMD
-
?
A:
[39-349]
------------
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
S-
G
E
---
D
F
L
V
D
I
V
M
H
L
T
-----------
R
A
--
G
--
G
K
R
F
R
P
M
F
A
L
L
A
S
E
F
G
E
K
P
--
L
----
S
E
--
N
V
I
K
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
M
D
-----------
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
S
Q
L
------
G
------
T
-
D
-
T
V
A
H
F
A
E
T
F
G
E
L
V
T
G
Q
-
M
R
E
T
V
G
P
R
D
-
T
D
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
---
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
-
Y
A
L
R
E
D
T
P
V
-----------
G
A
E
L
R
D
I
L
T
G
----
P
LE-------
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
---
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
----
D
----
R
L
P
D
S
T
V
------
K
E
A
L
R
N
L
A
T
F
T
V
K
R
V
G
41
HHSearch
43.66
23%
-78
- C1 -
3NF2
6
?
A:
[10-341]
------------
E
R
G
R
T
L
A
T
P
V
L
R
A
A
V
D
R
-
L
A
---
P
P
M
D
T
V
A
A
Y
H
F
GWIDAQGNPAD
G
D
--
G
--
G
K
A
V
R
P
A
L
A
V
L
S
A
E
V
T
G
A
A
-------
P
E
--
V
G
V
P
G
A
V
A
V
E
L
V
H
N
F
S
L
L
H
D
D
L
M
D
G
D
E
Q
R
R
H
R
D
T
V
W
K
V
H
G
P
A
Q
A
I
L
V
G
D
A
L
F
A
L
A
N
E
V
L
L
E
L
------
G
T
V
E
A
--
G
-
R
-
A
T
R
R
L
T
K
A
S
R
S
L
I
D
G
Q
-
A
Q
D
I
S
Y
E
H
R
D
R
V
S
V
E
E
C
L
E
M
E
G
N
K
T
G
A
L
L
A
C
A
S
S
I
G
A
V
L
G
G
---
A
D
E
R
T
A
D
T
L
E
K
Y
G
Y
H
L
G
L
A
F
Q
A
V
D
D
L
L
G
I
W
G
D
P
D
A
T
G
K
Q
T
W
S
D
L
R
Q
R
K
K
S
L
P
V
V
-
A
A
L
A
A
G
G
A
A
-----------
S
E
R
L
G
E
I
L
T
A
----
D
A
K
ASDFANF
S
E
E
E
F
A
A
R
A
A
L
I
E
E
A
G
G
R
---
E
W
T
A
D
E
A
R
R
Q
H
T
I
A
I
E
A
L
----
D
----
A
V
D
M
P
D
R
V
-----
R
D
R
F
T
A
L
A
D
F
V
V
V
---
46
HHSearch
43.60
23%
-99
- C1 -
3IPI
6
GFPS_METMA
A:
[7-284]
-----------
E
W
E
E
Y
R
Y
V
E
A
G
I
K
E
S
I
T
L
I
E
D
---
P
G
L
K
K
M
V
E
H
V
C
-----------
H
S
--
G
--
G
K
R
I
R
P
I
I
L
L
L
V
S
E
I
C
S
G
S
-------
Y
S
--
R
S
L
N
A
A
L
A
V
E
M
M
H
S
A
S
L
I
H
D
D
L
L
D
Q
G
L
V
R
R
N
L
P
S
A
P
E
K
F
G
P
S
G
A
L
L
C
G
D
Y
L
I
A
K
S
I
A
F
I
S
P
Y
------
G
------
E
-
K
-
V
I
Q
D
F
G
K
A
G
M
D
M
A
E
G
E
-
V
L
D
L
K
--------
E
N
D
Y
F
K
C
I
Y
K
K
T
A
S
L
F
A
I
S
A
S
I
G
A
Y
T
G
G
---
A
E
E
E
L
A
E
R
F
S
H
F
G
N
A
L
G
T
A
Y
Q
I
V
D
D
I
L
E
F
L
E
V
V
--
E
G
-----------
E
T
L
P
H
I
-
Y
M
K
S
T
S
K
E
E
---------------------------------------------------
A
L
---
K
K
S
I
D
C
V
K
L
H
V
A
A
A
K
E
T
L
----
E
----
T
F
R
E
C
P
A
------
R
D
K
L
F
Q
I
T
D
Y
I
T
V
D
M
L
20
PsiBlast_PDB
40.80
29%
-84
- C1 -
1V4K
6
?
A:
[15-273]
---------------------
K
V
K
E
R
I
E
--
Q
I
---
L
S
Q
F
F
P
E
Q
I
M
K
-----------
D
L
--
P
LY
G
K
M
L
R
V
R
L
--
S
I
L
S
F
K
N
R
G
V
E
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
V
H
L
A
F
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
------
N
-
N
K
L
R
R
A
F
L
N
V
I
G
K
M
S
E
A
E
L
I
E
Q
L
S
R
Y
K
P
I
T
--
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
-
G
M
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
----
M
F
E
N
R
----
D
---------
W
S
G
L
M
S
F
M
R
E
K
----
G
I
L
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
N
S
W
L
----
R
----
D
----------------------------
19
PsiBlast_PDB
38.44
29%
-82
- C1 -
1VG2
-
?
A:
[15-273]
---------------------
K
V
K
E
R
I
E
--
Q
I
---
L
S
Q
F
F
P
E
Q
I
M
K
-----------
D
L
--
P
LY
G
K
M
L
R
V
R
L
--
S
I
L
S
F
K
N
R
G
V
E
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
V
H
L
Y
S
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
------
N
-
N
K
L
R
R
A
F
L
N
V
I
G
K
M
S
E
A
E
L
I
E
Q
L
S
R
Y
K
P
I
T
--
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
-
G
M
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
----
M
F
E
N
R
----
D
---------
W
S
G
L
M
S
F
M
R
E
K
----
G
I
L
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
N
S
W
L
----
R
----
D
----------------------------
11
PsiBlast_PDB
38.26
29%
-80
- C1 -
1V4H
6
?
A:
[15-273]
---------------------
K
V
K
E
R
I
E
--
Q
I
---
L
S
Q
F
F
P
E
Q
I
M
K
-----------
D
L
--
P
LY
G
K
M
L
R
V
R
L
--
S
I
L
S
A
K
N
R
G
V
E
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
V
H
L
A
S
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
------
N
-
N
K
L
R
R
A
F
L
N
V
I
G
K
M
S
E
A
E
L
I
E
Q
L
S
R
Y
K
P
I
T
--
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
-
G
M
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
----
M
F
E
N
R
----
D
---------
W
S
G
L
M
S
F
M
R
E
K
----
G
I
L
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
N
S
W
L
----
R
----
D
----------------------------
17
PsiBlast_PDB
38.03
29%
-82
- C1 -
1V4J
5
?
A:
[15-273]
---------------------
K
V
K
E
R
I
E
--
Q
I
---
L
S
Q
F
F
P
E
Q
I
M
K
-----------
D
L
--
P
LY
G
K
M
L
R
V
R
L
--
S
I
L
S
F
K
N
R
G
V
E
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
Y
H
L
A
S
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
------
N
-
N
K
L
R
R
A
F
L
N
V
I
G
K
M
S
E
A
E
L
I
E
Q
L
S
R
Y
K
P
I
T
--
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
-
G
M
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
----
M
F
E
N
R
----
D
---------
W
S
G
L
M
S
F
M
R
E
K
----
G
I
L
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
N
S
W
L
----
R
----
D
-
F
--------------------------
22
PsiBlast_CBE
38.00
31%
-75
- C1 -
3WJN
1
?
B:
[60-314]
--------------------------------------------------------------------
R
I
R
P
M
I
A
V
L
A
A
R
A
V
G
Y
-
E
----
G
N
--
A
H
V
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
V
D
E
S
------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
S
L
------
G
------
S
L
K
-
V
L
E
V
M
S
E
A
V
N
V
I
A
E
G
E
-
V
L
Q
L
M
N
V
N
D
P
D
I
T
E
E
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
CT
P
E
E
E
---
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
P
E
Q
A
----------
Q
M
I
R
T
A
I
E
Q
G
----
N
---------
G
R
H
L
L
E
P
V
L
E
A
M
N
A
C
G
S
L
---
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
----
Q
----
V
-
L
P
---------
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
14
PsiBlast_PDB
37.64
29%
-79
- C1 -
1V4I
6
?
A:
[15-273]
---------------------
K
V
K
E
R
I
E
--
Q
I
---
L
S
Q
F
F
P
E
Q
I
M
K
-----------
D
L
--
P
LY
G
K
M
L
R
V
R
L
--
S
I
L
S
F
K
N
R
G
V
E
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
V
H
L
A
S
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
------
N
-
N
K
L
R
R
A
A
L
N
V
I
G
K
M
S
E
A
E
L
I
E
Q
L
S
R
Y
K
P
I
T
--
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
-
G
M
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
----
M
F
E
N
R
----
D
---------
W
S
G
L
M
S
F
M
R
E
K
----
G
I
L
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
N
S
W
L
----
R
----
D
----------------------------
62
Fugue
37.34
25%
-79
- C1 -
1V4E
4
?
A:
[9-288]
-----------
N
S
Y
E
L
E
K
V
K
E
R
I
E
Q
I
L
S
--
Q
F
---
F
P
E
Q
I
M
K
D
L
P
L
-----------
Y
G
------
K
M
L
R
V
R
L
S
I
L
S
F
K
N
R
G
V
E
--
I
----
G
E
--
D
A
I
S
S
L
A
A
L
E
L
V
H
L
A
S
L
L
H
D
D
V
I
D
G
A
R
F
R
R
G
K
E
T
I
N
F
M
Y
G
D
K
A
A
V
A
A
G
D
L
V
L
V
S
A
F
H
T
V
E
E
I
------
G
N-----
N
-
K
-
L
R
R
A
F
L
N
V
I
G
K
M
S
E
A
E
-
L
I
E
Q
L
S
R
Y
-
K
P
I
T
K
E
E
Y
L
R
I
V
E
G
K
S
G
A
L
F
G
L
A
L
Q
L
P
A
L
L
E
G
---
E
L
G
---
E
D
L
Y
N
L
G
V
T
I
G
T
I
Y
Q
M
F
D
D
I
M
D
F
A
G
M
-
E
K
I
G
K
D
G
F
L
D
L
K
N
G
V
A
S
F
P
L
V
-
T
A
M
E
K
F
P
E
A
R
----------
Q
M
F
E
---------------------
N
R
D
W
S
G
L
M
S
F
M
R
E
K
G
I
L
---
K
E
C
E
E
T
L
K
V
L
V
K
N
V
I
I
E
--------------------------------
N
S
W
L
R
D
F