@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0350: (2015-12-14 )
MKKIWLLVWGLYSLAFLHAIETIEKAPTNVEDRDKAPHLLLLAGIQGDEPGGFNATNLFLMHYSVLKGLVEVVPVLNKPSMLRNHRGLYGDMNRKFAALDKNDPEYPTIQEIKSLIAKPSVDAVLHLHDGGGYYRPVYIDAMLNPKRWGNCFIIDQDEVKGAKFPNLLAFANNTIENINAHLLHPIEKYHLKNTRTAQGDTEMQKALTFYAINQKKSAFANEASKELPLESRVFYHLQAIEGLLNQLNIPFKRDFELNPNSVHALINDKSLWAKISSLPKMPLFNLRPKLNHFPLPSNTKIPQIPIESNAYIVGLVKNKQEVFLKYGNKLMTRLSPFYIEFDHSLEEVKMQIDNKDQMVKIGSVVEVKESFYIHAMDNIRANVIGFSVSNESKPNETGYTIKFKDFQKRFSLDKQERIYRIEFYKNNAFSGMILVKFV
Atome Classification :
(20 SA)
--------------.........10........20........30..-......40........50......-.-.60..------------.------------.--....70........80...-.---------.-----------------.-------.---.90........100--.-----------------------------------.---.----------------......110---..---....------.-120.......130..-.-....140...---....150-.......160.......-170.......180-.-........190.......200.....-..210.-----.------.-.....220.....-.-.-230.----....---..240.......250..-.....260......-.270...-....280.......290.......300.......310......-.320.......330.......340......-.350.......360.......-370.......-380.......390.......400.......410.......420.......430.....-.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------M
K
K
I
W
L
L
V
W
G
L
Y
S
L
A
F
L
H
A
I
E
T
I
E
KAPTNVEDR-DKAP
H
L
L
L
L
AGIQGDEPGGF
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
PVLN
K
P
S
M
L
R
N-H---------R-----------------G-------L---YGDMNR
K
F
AALD----K-----------------------------------N---D----------------PEYP
T
I
Q
E
I
---
K
S
---
L
IAK------P-S
V
D
A
V
L
H
L
HDGGG
Y
Y
-
R
-
P
V
Y
I
D
AMLNP---KRWG
N
C
F
-
I
I
DQDEVKGAKFP
N
L
L
A
-
F
ANN
T
I
E
NI
N
A
---
H
-
L
LHP
I
E
K
Y
HLKNTRTAQG
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I-----N------
Q
-
K
K
S
A
F
AN
E
A
S
KEL-P-
L
-
E
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
QLNIPFKRD-FELNPNS
V
H
A
L
IND-
K
S
L
W
A
K
I
-
S
SLPKMPLFNLRPKLNHFPLPSNTKI
P
Q
IPIESN
A
Y
I
V
G
L
VKN-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
RLS
P
F
Y
I
EFDH
S
L
E
E
V
-
K
M
QIDNKD
Q
M
V
K
IG
S
V
V
E
V
KE-
S
F
Y
I
H
AMDNI-
R
A
N
V
I
G
F
SVSNESKPNET
G
Y
T
I
K
F
K
D
F
Q
K
R
FSL
D
K
Q
E
R
I
Y
R
I
E
F
Y
KNNAFS
G
M
I
L
V
K
F-V-----
36
Fugue
98.59
97%
-96
- C4 -
4Q6O
8
?
A:
[21-437]
-----------------------------------
M
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
4
PsiBlast_PDB
98.43
97%
-101
- C4 -
4Q6P
9
?
A:
[22-437]
------------------------------------
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
5
PsiBlast_PDB
97.47
97%
-98
- C4 -
4Q6Q
5
?
A:
[22-437]
------------------------------------
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
2
PsiBlast_PDB
97.43
97%
-98
- C4 -
4Q6N
7
?
A:
[22-437]
------------------------------------
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
3
PsiBlast_PDB
97.10
97%
-96
- C4 -
4Q6O
8
?
A:
[22-437]
------------------------------------
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
1
PsiBlast_PDB
96.88
97%
-95
- C4 -
4Q6M
4
?
A:
[22-437]
------------------------------------
I
E
K
A
P
T
N
V
E
D
R
-
D
K
A
P
H
L
L
L
L
A
G
I
Q
G
D
E
P
G
G
F
N
A
T
N
-
L
-
F
L
M
H
Y
------------
S
------------
V
--
L
K
G
L
V
E
V
V
P
V
L
N
K
P
S
M
L
R
N
-
H
---------
R
-----------------
G
-------
L
---
Y
G
D
M
N
R
K
F
A
A
L
D
----
K
-----------------------------------
N
---
D
----------------
P
E
Y
P
T
I
Q
E
I
---
K
S
---
L
I
A
K
------
P
-
S
I
D
A
V
L
H
L
H
D
G
G
G
Y
Y
-
R
-
P
V
Y
V
D
A
M
L
N
P
---
K
R
W
G
N
C
F
-
I
I
D
Q
D
E
V
K
G
A
K
F
P
N
L
L
A
-
F
A
N
N
T
I
E
S
I
N
A
---
H
-
L
L
H
P
I
E
E
Y
H
L
K
N
T
R
T
A
Q
G
D
T
E
M
Q
K
A
L
-
T
F
Y
-
A
I
-----
N
------
Q
-
K
K
S
A
F
A
N
E
A
S
K
E
L
-
P
-
L
-
A
S
R
V
----
F
Y
H
L
---
Q
A
I
E
G
L
L
N
Q
L
N
I
P
F
K
R
D
-
F
D
L
N
P
N
S
V
H
A
L
I
N
D
-
K
N
L
W
A
K
I
-
S
S
L
P
K
M
P
L
F
N
L
R
P
K
L
N
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-
K
Q
E
V
F
L
K
Y
G
N
K
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
-
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
E
-
S
F
Y
I
H
A
M
D
N
I
-
R
A
N
V
I
G
F
S
V
S
N
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
-
V
-----
17
HHSearch
46.91
14%
-42
- C4 -
3NA6
3
?
A:
[37-286]
------------------------------------
V
M
I
P
I
T
V
I
Q
N
G
--
A
G
K
T
A
L
L
T
G
A
N
H
G
D
E
Y
E
G
P
V
A
L
Q
-
E
-
L
A
A
T
T
RA----------
E
------------
D
--
V
T
G
R
L
I
I
V
P
Y
F
N
Y
P
A
F
R
A
S
-
A
---------
R
-----------------
T
-------
S
PID
R
G
N
L
N
R
A
F
P
G
R
P
----
D
-----------------------------------
G
---
T
----------------
V
T
Q
K
I
A
D
Y
F
---
Q
R
---
T
L
L
-------
P
-
M
A
D
V
A
V
D
F
H
S
G
G
K
T
L
D
F
-
V
P
F
A
A
A
H
--------------
I
L
E
D
K
--------
V
L
Q
D
-
A
C
F
A
A
M
Q
A
F
N
A
---
P
-
Y
S
V
Q
-----
L
L
--
E
-----
I
D
S
E
G
M
Y
-
D
T
A
-
V
E
-----
E
------
M
-
G
K
V
L
V
T
T
E
L
G
G
G
G
-
M
S
T
-
A
R
S
N
----
A
I
A
K
---
K
G
L
R
N
V
L
I
H
F
G
I
L
Q
G
E
M
-
Q
I
-
D
P
S
V
T
L
D
M
P
D
G
-
D
C
Y
L
F
S
E
-
H
D
G
L
-
F
E
I
----
M
I
D
L
G
E
P
V
Q
E
G
D
L
V
A
R
V
W
S
P
D
R
T
G
E
A
P
V
E
Y
R
-
A
R
R
S
G
V
L
I
S
R
H
F
P
G
M
I
K
S
G
D
C
A
A
V
I
G
V
V
E
----------------------------------------------------------------------------------------------------
23
HHSearch
46.32
16%
-42
- C4 -
3B2Y
1
?
A:
[65-271]
-------------------------------------------------
D
L
P
S
L
L
I
S
S
G
F
H
G
E
E
A
A
G
P
W
G
M
L
-
H
-
F
L
R
G
L
QP
A
---------
L
------------
F
--
E
R
V
N
L
S
L
L
P
L
V
N
P
T
G
F
K
A
G
-
H
---------
R
-----------------
F
-------
N
RF-
G
E
N
P
N
R
G
F
T
L
---------------------------------------------------------------
H
T
S
L
E
G
K
L
L
L
E
H
A
Q
---
L
L
C
A
------
A
-
S
R
D
G
I
L
T
C
H
E
D
V
L
M
N
-
E
-
T
-
Y
V
Y
S
F
E
P
T
---
Q
T
P
G
-
R
--
F
-
S
-------
L
--
G
L
R
D
-
A
L
G
Q
Y
F
-
K
L
A
K
----------
F
I
D
E
C
P
V
T
D
G
-
V
I
F
N
H
F
D
T
S
F
-
E
A
F
-
L
V
-----
R
------
S
G
A
K
L
A
A
C
S
E
T
P
G
Q
E
-
D
-
F
-
D
R
R
V
----
Q
A
N
S
---
A
A
M
G
Q
F
I
A
H
C
A
P
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
46.00
22%
-49
- C4 -
1YW6
1
ASTE_ECOLI
A:
[39-291]
-----------------------------------------
L
E
L
T
P
L
T
P
P
Q
G
A
L
V
I
S
A
G
I
H
G
N
E
T
A
P
V
E
M
L
D
-
A
-
L
L
G
A
I
------------
S
H
GEI--------
P
--
L
R
W
R
L
L
-
V
I
L
G
N
P
P
A
L
K
Q
G
-
K
---------
R
------------------------------
S
D
M
N
R
M
F
G
G
R
W
----
Q
-----------------------------------
L
FAE
S
----------------
G
E
T
C
R
A
R
E
L
---
E
Q
---
C
L
E
D
F
Y
D
QGK
E
-
S
V
R
W
H
L
D
L
H
T
A
I
R
G
S
L
H
-
P
Q
F
G
V
L
---
P
-------
Q
R
----
D
I
------
P
---
W
D
E
-
K
F
L
T
W
L
G
A
A
G
L
---
E
-
A
L
-------
V
F
H
-------
Q
E
P
G
G
T
F
-
T
H
F
S
A
R
-----
H
------
F
-
G
A
L
A
C
T
L
E
L
G
K
A
L
---------LRQF
A
V
T
A
---
S
A
I
A
A
L
L
S
G
E
S
V
G
I
V
R
-----
T
P
P
L
R
Y
R
V
V
----
S
Q
I
T
R
H
-
S
P
S
F
E
M
H
M
A
S
--
D
T
L
N
F
M
P
F
E
K
G
T
L
L
A
Q
D
G
E
E
R
F
T
V
T
H
D
V
E
Y
V
-
L
F
P
N
P
L
V
A
L
G
L
R
A
G
L
M
L
E
K
I
S
------------------------------------------------------------------------------------------------------------
20
HHSearch
45.84
20%
-46
* C4 *
3CDX
1
?
A:
[41-247]
------------------------------------
V
E
I
P
I
T
V
V
K
N
G
--
S
G
P
T
V
L
L
T
G
G
V
H
G
D
E
Y
E
G
Q
I
A
I
S
-
D
-
L
A
R
R
L
RP----------
E
------------
E
--
V
Q
G
R
V
I
M
L
P
A
V
N
M
P
A
I
Q
S
D
-
T
---------
R
-----------------
L
-------
S
PVD
G
R
D
I
N
R
C
F
P
G
D
P
----
R
-----------------------------------
G
---
T
----------------
F
S
Q
M
L
A
H
F
L
---
D
S
---
V
I
L
P
--------
M
A
D
I
S
V
D
M
H
T
A
G
H
S
Y
-
D
S
T
P
S
T
N
M
H
Y
L
A
-------------
D
-
P
--------
A
L
R
A
-
R
T
L
A
A
A
E
A
F
G
A
---
P
-
H
N
V
------
V
F
------
G
-----
S
T
F
-
T
S
C
-
V
E
-----
R
------
R
-
G
I
V
S
L
G
T
E
L
G
G
W
G
-
R
V
N
-
I
E
G
V
----
R
I
G
K
---
R
G
I
L
N
V
L
K
H
M
G
V
I
E
G
T
P
-
E
T
A
Q
R
G
G
A
A
G
T
R
H
M
-
M
V
R
E
A
D
A
-
Y
V
M
A
P
R
T
G
L
F
E
P
T
H
Y
V
G
E
E
V
R
T
G
E
T
A
G
W
I
H
F
V
E
D
V
D
T
A
P
L
E
L
L
-
Y
R
R
D
G
I
V
W
F
G
A
G
P
G
R
V
T
R
G
D
A
V
A
V
V
M
E
D
Y
N
-
D
-------------------------------------------------------------------------------------------------
22
HHSearch
45.19
14%
-38
- C4 -
3FMC
3
?
A:
[18-275]
----------------------------------
Q
P
L
S
L
P
V
Y
R
F
K
G
K
-
G
A
G
P
S
V
Y
I
Q
A
N
V
H
G
A
E
V
Q
G
N
A
V
I
Y
-
Q
-
L
M
K
L
L
E
H----------
Y
------------
E
--
L
L
G
D
I
S
L
V
P
L
A
N
P
L
G
I
N
Q
K
-
S
GEFTLG---
R
-----------------
F
-------
D
PIT
G
V
N
W
N
R
E
Y
L
D
H
G
----
F
N
I
E
V
W
Y
Q
E
H
SHLD
D
D
T
L
I
T
A
F
R
A
T
L
V
E
E
C
A
R
R
L
N
N
P
WGV
T
----------------
T
G
H
R
L
A
V
T
L
---
Q
S
---
M
A
--------
H
-
R
A
D
I
V
L
D
L
H
T
G
P
K
S
C
-
K
---
H
L
Y
--
C
P
E
------------------------
Y
-----
E
R
S
A
A
Q
Y
F
S
I
---
P
-
Y
T
L
L
I
P
---
N
S
F
G
G
A
M
---
D
E
-
A
A
F
V
-
P
W
W
-
T
L
A
E
V
A
S
S
H
GRELG
V
-
R
V
S
A
L
T
L
E
L
G
S
Q
E
-
R
I
D
-
L
D
D
A
----
L
E
D
A
---
E
G
I
L
A
Y
L
S
H
R
G
V
I
A
E
T
V
-
L
P
K
P
M
K
R
Y
G
C
F
L
K
N
-
Y
R
K
F
H
A
P
-
K
A
G
M
V
E
Y
L
G
K
V
G
V
P
M
K
A
T
D
P
L
V
N
L
L
R
L
D
L
Y
G
T
G
E
E
L
T
V
L
R
L
P
E
-
D
G
V
P
I
L
H
F
A
S
A
S
V
H
Q
G
T
E
L
Y
K
V
M
T
K
V
F
E
L
----------------------------------------------------------------------------------------------------
40
Fugue
44.15
14%
-10
- C4 -
2QJ8
-
?
A:
[2-331]
SEAPHLTFDLDTP
G
V
S
T
G
H
L
V
V
P
K
G
A
D
-------
C
E
A
L
S
L
P
V
F
S
C
N
R
-
G
E
G
P
S
L
L
I
T
G
G
N
H
G
N
E
L
Q
G
P
I
L
A
R
-
R
-
L
V
K
W
L
------------
P
------------
E
AQ
R
C
G
R
I
I
I
V
P
E
I
N
P
L
A
V
Q
A
W
-
T
---------
R
-----------------
N
-------
T
PID
G
K
N
L
N
R
V
F
P
G
R
S
----
D
-----------------------------------
G
---
S
----------------
V
S
E
R
I
A
D
A
I
---
S
R
---
L
L
L
P
------
V
--
V
D
T
V
L
D
L
H
S
F
G
P
---
T
-
W
D
C
A
P
S
I
I
S
H
---
P
I
A
D
I
D
Q
M
T
K
T
V
S
I
S
K
A
F
K
L
P
V
T
L
L
-
W
E
H
N
E
----
T
D
---
G
M
F
D
T
L
V
H
R
Q
G
K
T
F
I
C
T
E
F
G
G
G
L
T
I
Y
E
A
-
G
V
R
-
N
G
-----
L
------
I
-
A
L
G
L
V
K
G
K
A
G
Q
T
L
-
E
-
T
-
T
S
S
D
----
Q
L
K
S
---
P
S
-
P
G
I
F
E
P
----
R
C
S
V
M
D
E
V
E
Q
G
D
V
V
G
V
L
H
P
M
G
---------------------------
S
L
S
A
A
S
I
D
I
R
A
Q
S
K
S
T
V
F
A
I
R
S
A
M
Y
---------------------------------
V
Q
G
N
E
E
V
A
I
L
A
R
P
L
A
R
-------------------------------------------------------------------------------
24
HHSearch
43.48
17%
-45
- C4 -
2QVP
3
?
A:
[64-271]
-------------------------------------------------
G
L
P
N
L
L
I
S
A
G
F
H
G
E
E
S
A
G
P
W
G
L
L
-
H
-
F
L
S
Q
L
DG
E
---------
L
------------
F
--
K
R
V
N
L
S
V
L
P
L
V
N
P
T
G
F
A
K
G
-
H
---------
R
-----------------
F
-------
N
EL-
G
E
N
P
N
R
G
F
F
I
E
N
G
K
A
K
P
-----------------------------------
G
---
A
----------------
D
T
S
A
E
G
R
I
L
---
L
E
H
A
H
L
L
Q
V
------
A
-
S
R
D
G
I
L
T
C
H
E
D
V
L
M
T
-
D
-
T
-
Y
V
Y
T
F
E
P
S
QAP
G
R
F
S
H
S
----------------
L
R
D
A
L
G
Q
Y
F
P
I
A
A
D
G
---
D
-
V
D
N
C
P
V
R
S
G
V
I
F
-------
N
H
F
D
T
S
F
-
E
S
F
-
L
V
-----
R
------
S
G
A
R
V
G
C
C
S
E
T
P
G
Q
Q
-
P
-
L
-
D
Q
R
I
----
L
A
N
A
---
A
A
M
N
T
F
V
N
M
L
A
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
42.16
16%
-48
- C4 -
2QJ8
-
?
A:
[32-236]
------------------------------------
L
S
L
P
V
F
S
C
N
R
G
--
E
G
P
S
L
L
I
T
G
G
N
H
G
N
E
L
Q
G
P
I
L
A
R
-
R
-
L
V
K
W
L
PE----------
A
------------
Q
--
R
C
G
R
I
I
I
V
P
E
I
N
P
L
A
V
Q
A
W
-
T
---------
R
-----------------
N
-------
T
PID
G
K
N
L
N
R
V
F
P
G
R
S
----
D
-----------------------------------
G
---
S
----------------
V
S
E
R
I
A
D
A
I
---
S
R
---
L
L
L
P
--------
V
V
D
T
V
L
D
L
H
S
F
G
P
T
W
-
D
--------
C
A
P
-------
S
I
--
I
S
H
P
I
A
----
D
I
-
D
Q
M
T
-
K
T
V
S
I
S
K
A
F
K
L
---
P
-
V
T
L
-----
L
W
E
--
H
-----
N
E
T
D
G
M
F
-
D
T
L
-
V
H
-----
R
------
Q
-
G
K
T
F
I
C
T
E
F
G
G
G
---------
L
----
T
I
Y
E
---
A
G
V
R
N
G
L
I
A
L
G
L
V
K
G
K
A
-
G
Q
T
L
E
T
T
S
S
D
Q
L
K
S
-
P
S
P
G
I
F
E
-
P
R
C
S
V
M
D
E
V
E
Q
G
D
V
V
G
V
L
H
P
M
G
S
L
S
A
A
S
I
D
I
R
A
Q
S
K
S
T
V
F
A
I
R
-
S
A
M
Y
V
Q
G
N
E
E
V
A
I
L
A
R
P
L
A
R
-------------------------------------------------------------------------------------------------------------
25
HHSearch
41.81
18%
-57
- C4 -
1DTD
2
CBPA2_HUMAN
A:
[44-195]
-----------------------------------------
L
K
F
S
T
G
-
G
D
K
P
A
I
W
L
D
A
G
I
H
A
R
E
W
V
T
Q
A
T
A
L
-
W
-
T
A
N
K
I
------------
V
S
D
YGKD
P
S
I
T
S
I
L
--
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
-
Q
---------
T
KNRMWRKTRSKVSAGSL
C
-------
V
---
G
V
D
P
N
R
N
W
D
A
G
F
----
G
-----------------------------------
G
---
P
GASSNPCSDSYHGPSA
N
S
E
V
E
V
K
S
I
---
V
D
---
F
I
K
S
------
H
G
K
V
K
A
F
I
I
L
H
S
Y
S
Q
L
L
-
M
-
F
P
Y
G
Y
K
C
T
K
L
---
D
D
F
D
E
L
S
-
E
V
A
Q
K
A
A
Q
S
L
S
R
L
H
G
T
K
-
Y
K
V
G
P
I
C
S
V
I
Y
---
Q
-
A
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
-
R
Y
G
-
F
L
-----
L
------
P
-
A
R
Q
I
L
P
T
A
E
E
T
W
L
-
G
-
L
-
K
A
I
M
----
E
H
V
R
---
D
H
P
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
41.80
16%
-56
- C4 -
3L2N
4
?
A:
[173-283]
------------------------------------------------
P
S
K
K
S
I
W
I
T
A
R
Q
H
P
G
E
T
M
A
E
W
L
V
E
-
G
-
L
L
N
Q
L
L
DNDC
P
T
S
K
A
--
L
------------
L
--
D
K
A
N
F
Y
I
V
P
N
M
N
P
D
G
S
V
R
G
H
L
---------
R
-----------------
T
-------
N
AV-
G
A
N
L
N
R
E
W
Q
T
P
S
----
L
-----------------------------------
E
---------------------
R
S
P
E
V
Y
Y
V
---
V
N
---
K
M
H
E
------
T
-
G
V
D
L
F
Y
D
V
H
G
D
E
G
L
P
-
Y
-
V
F
L
A
G
C
E
G
I
P
---
N
Y
S
D
K
L
A
-
S
L
Q
Q
D
F
V
A
A
L
S
L
A
S
A
D
F
-
Q
T
E
F
G
Y
D
K
D
E
P
---
G
-
K
A
N
L
T
V
A
C
N
W
V
A
N
T
F
K
C
L
S
N
T
L
E
M
P
F
-
K
D
N
-
A
N
-----
L
------
A
-
D
P
F
Q
G
W
S
P
E
R
S
V
Y
-
F
-
G
-
E
A
S
L
----
I
A
M
R
---
A
V
I
D
K
I
G
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
41.76
19%
-55
- C4 -
1AYE
1
CBPA2_HUMAN
A:
[145-293]
-------------------------------------------
F
S
T
G
-
G
D
K
P
A
I
W
L
D
A
G
I
H
A
R
E
W
V
T
Q
A
T
A
L
-
W
-
T
A
N
K
I
V
S
D
YGKD
P
S
I
T
S
I
------------
L
--
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
-
Q
T
KNRMWRKT
R
SKVSG------------
S
L
C
-----
V
---
G
V
D
P
N
R
N
W
D
A
G
F
----
G
-----------------------------------
G
---
P
GASSNPCSDSYHGPSA
N
S
E
V
E
V
K
S
I
---
V
D
---
F
I
K
S
------
H
G
K
V
K
A
F
I
I
L
H
S
Y
S
Q
L
L
-
M
-
F
P
Y
G
Y
K
C
T
K
L
---
D
D
F
D
E
L
S
-
E
V
A
Q
K
A
A
Q
S
L
R
S
L
H
G
T
K
-
Y
K
V
G
P
I
C
S
V
I
Y
---
Q
-
A
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
-
R
Y
G
-
F
L
-----
L
------
P
-
A
R
Q
I
L
P
T
A
E
E
T
W
L
-
G
-
L
-
K
A
I
M
----
E
H
V
R
---
D
H
P
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
40.50
11%
-28
- C4 -
3FMC
4
?
A:
[4-368]
--------------
V
D
K
H
E
V
R
V
G
E
L
A
A
G
Q
P
L
S
L
P
V
Y
R
F
K
G
K
-------
G
A
G
P
S
V
Y
I
Q
A
N
V
H
G
A
E
V
Q
G
N
A
V
I
Y
Q
L
M
K
L
L
E
H
------------
Y
------------
E
--
L
L
G
D
I
S
L
V
P
L
A
N
P
L
G
I
N
Q
K
-
S
---------
G
-----------------
E
-----------------------------------------------------------------------------------------------------------------
F
T
L
G
R
F
D
P
I
T
G
V
N
W
N
-
R
-
E
Y
-----------------------
L
D
H
G
F
N
I
E
V
W
Y
Q
E
-
H
S
H
L
D
D
D
T
L
I
T
---
A
-
F
R
A
T
L
V
E
E
C
A
R
R
L
N
N
P
W
G
V
T
T
G
H
R
L
A
-
V
T
L
-
Q
---------------------------
S
M
A
-
H
-
R
A
D
I
----
V
L
D
L
---
H
T
G
P
K
S
C
K
H
L
Y
C
P
E
Y
E
R
-
S
A
A
Q
Y
F
S
I
P
Y
T
L
L
I
-
P
N
S
F
G
G
A
M
D
E
A
A
F
V
P
W
W
T
L
A
E
V
A
S
S
H
G
R
E
L
G
V
R
V
S
A
L
T
L
E
L
G
----
S
Q
E
R
I
-
D
L
D
D
A
L
E
D
A
E
G
I
L
A
Y
L
S
H
R
G
V
I
A
E
T
V
L
P
K
P
M
K
R
Y
G
C
F
L
K
N
Y
R
K
F
H
A
--
P
K
A
G
M
V
E
Y
L
G
K
V
G
V
P
M
K
A
T
D
P
L
V
N
L
L
R
L
D
L
Y
G
T
G
E
E
L
T
V
L
R
L
P
E
D
G
V
P
I
L
H
F
A
S
--------
A
S
V
H
Q
G
T
E
L
Y
K
V
M
T
KVFEL
27
HHSearch
39.87
19%
-58
- C4 -
2BO9
5
CBPA4_HUMAN
A:
[57-200]
-------------------------------------------------
R
R
P
A
V
W
L
N
A
G
I
H
S
R
E
W
I
S
Q
A
T
A
I
-
W
-
T
A
R
K
I
------------
V
S
D
YQRD
P
A
I
T
S
I
L
--
E
K
M
D
I
F
L
L
P
V
A
N
P
D
G
Y
V
Y
T
-
Q
TQNRLWRKT
R
-----------------
S
RNPGSS
C
I
---
G
A
D
P
N
R
N
W
N
A
S
F
----
A
-----------------------------------
G
---
K
GASDNPCSEVYHGPHA
N
S
E
V
E
V
K
S
V
---
V
D
---
F
I
Q
K
------
H
G
N
F
K
G
F
I
D
L
H
S
Y
S
Q
L
L
-
M
-
Y
P
Y
G
Y
S
V
K
K
A
---
P
D
A
E
E
L
D
-
K
V
A
R
L
A
A
K
A
L
A
S
V
S
G
T
E
-
Y
Q
V
G
P
T
C
T
T
V
Y
---
P
-
A
S
G
S
S
I
D
W
A
Y
D
N
G
I
K
F
A
F
T
F
E
L
R
D
T
G
-
T
Y
G
-
F
L
-----
L
------
P
-
A
N
Q
I
I
P
T
A
E
E
T
W
L
-
G
-
L
-
K
T
I
M
----
E
H
V
R
---
D
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
39.82
12%
-25
- C4 -
2BCO
1
ASTE_VIBPA
A:
[42-295]
--------------------------------------
L
E
V
I
P
E
N
P
T
-
Q
E
T
K
N
I
I
I
S
C
G
I
H
G
D
E
T
A
P
M
E
L
V
D
-
S
-
I
I
K
D
I
E
S
GF--------
Q
------------
K
--
V
D
A
R
C
L
-
F
I
I
A
H
P
E
S
T
L
A
H
-
T
---------
R
-----------------
F
-------
L
---
E
E
N
L
N
R
L
F
D
E
K
E
----
H
-----------------------------------
E
P--
T
----------------
K
E
L
A
I
A
D
T
L
---
K
L
---
L
V
R
D
F
Y
QDTE
P
-
K
T
R
W
H
L
D
L
H
C
A
I
R
G
S
-
K
-
H
-------
Y
T
-------
F
A
--
V
S
P
K
T
R
--------
H
P
V
-
R
S
K
A
L
V
D
F
L
D
S
A
HI
E
-
A
V
-------
L
L
S
-------
N
S
P
S
S
T
F
S
W
Y
S
-
A
E
-----
N
------
Y
-
S
A
Q
A
L
T
M
E
L
G
R
V
A
-
R
-
I
G
E
N
A
L
----
D
R
L
T
A
F
D
L
A
L
R
N
L
I
A
E
A
Q
P
E
H
L
-
S
----
K
P
C
I
K
Y
R
V
S
R
T
-
I
V
R
L
H
D
D
F
D
F
M
F
D
D
N
V
------
E
N
F
T
S
F
V
H
G
E
V
F
G
H
D
G
D
K
P
L
M
A
K
N
D
N
E
A
I
-
V
F
P
N
R
H
V
A
I
G
Q
R
A
A
L
M
V
C
E
V
K
T
R
F
E
E
G
E
L
V
-
Y
D
------------------------------------------------------------------------------------------------