@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1294: (2015-12-22 )
MKAGIIGLGLMGGSLGLALQEWGRFKSVIGYDHNALHAKLALTLGLVDECVEFEKILECDVIFLAIPVEGIIECLKKMTPIKKSATIIDLGGAKAQILHNIPKSIRQNFIAAHPMCGTEFYGPKASVKGLYENALVILCDLEDSGTEQVEIAKEIFLGIKARLIKMKSNEHDTHVAYISHLPHVLSYALANSVLKQNDPEMILSLAGGGFRDMSRLSKSSPLMWKDIFKQNRDNVLEAIEKCEKEIAQAKAWIENNDYESLAEWMAQANKLQEFM
Atome Classification :
(20 SA)
.........10........20........30........40.......-.-50--.--....--.--.-----.-.--60........70........80.--........90...----.....100....---..---..110.......120.......130.....-----..140....--------...150....---...160.......170.......180.......190.--...-----.-..-200........210.......220.......230.......240.......250.......260.......270...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAG
I
I
G
L
GLMGG
S
L
G
L
A
L
Q
E
W
G
R
F
K
S
V
IGYDHN
A
L
H
A
K
L
A
L
T
L
G
L
V
D
-
E
-
C
---
V
--
E
F
E
K
--
I
--L-----E-C--
D
V
I
F
L
A
I
P
V
E
G
I
I
E
C
L
K
K
MTP-I--KKS
A
T
I
I
DLGG
A
K
----
A
Q
I
L
H
N
I
-
P
K
S
I
---
R
Q
---
N
F
I
AAHPMCGTEFYGPK
A
S
V
K
G
LYEN
A
L
V
I
-----
L
CDLEDSGT--------
E
Q
V
E
I
A
K
E
I
F
---
L
G
I
K
A
R
L
I
K
MKSNEHD
T
H
V
A
Y
I
S
H
L
P
H
V
L
S
Y
A
L
A
N
S
V
--LKQ-----N-
D
P
-
E
M
-
I
L
S
LAGG
G
F
R
D
M
S
R
LSKSSP
L
M
W
K
D
I
F
K
QN
R
D
N
V
L
E
A
I
E
K
C
E
K
E
I
A
Q
A
K
A
W
IENN
D
Y
E
S
L
A
E
W
M
A
Q
A
N
K
L
Q
E
FM
27
PsiBlast_CBE
95.80
31%
-116
- C2 -
3GGG
2
?
C:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L
-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
-----
25
PsiBlast_CBE
95.55
31%
-112
- C2 -
3GGO
2
?
C:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
-----
1
PsiBlast_PDB
95.13
31%
-119
- C2 -
3GGG
2
?
D:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
29
PsiBlast_CBE
94.42
31%
-118
- C2 -
3GGG
2
?
A:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
24
PsiBlast_CBE
94.19
31%
-121
- C2 -
3GGO
2
?
D:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
--
26
PsiBlast_CBE
93.96
31%
-111
- C2 -
3GGO
2
?
B:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
-
21
PsiBlast_CBE
93.87
31%
-116
- C2 -
3GGP
3
?
D:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
22
PsiBlast_CBE
93.67
31%
-111
- C2 -
3GGP
3
?
C:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
2
PsiBlast_PDB
93.61
31%
-115
- C2 -
3GGO
2
?
A:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
3
PsiBlast_PDB
93.55
31%
-116
- C2 -
3GGP
3
?
A:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
28
PsiBlast_CBE
92.70
31%
-114
- C2 -
3GGG
2
?
B:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---
23
PsiBlast_CBE
92.46
31%
-110
- C2 -
3GGP
3
?
B:
[38-306]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
-
30
HHSearch
91.70
30%
-112
- C2 -
2G5C
1
?
A:
[2-280]
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
VE
D
--
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
L
--
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
T
P
E
-
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
---
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
4
PsiBlast_PDB
91.49
30%
-119
- C2 -
2G5C
1
?
A:
[6-274]
----
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
-
E
G
T
---
T
--
S
I
A
K
--
V
ED
F
-----
S
-
P
--
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
L
-
S
E
D
A
T
V
T
D
Q
G
S
V
K
----
G
K
L
V
Y
D
L
-
E
N
I
L
---
G
K
---
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
-----
L
T
P
T
K
K
T
D
K
--------
K
R
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
--
I
H
M
-----
S
-
T
P
-
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
---
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
31
HHSearch
90.28
29%
-103
- C2 -
3B1F
1
?
A:
[7-289]
K
T
I
Y
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
H
P
H
Y
K
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
E
A
-
T
---
A
--
D
F
K
V
F-
A
--
A
-----
L
-
A
--
D
V
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
L
D
L-
K
E
D
V
I
I
T
D
A
G
S
T
K
----
Y
E
I
V
R
A
A
-
E
Y
Y
L
KDK
P
V
---
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
-----
F
S
P
S
C
L
T
K
P
--------
N
T
I
P
A
L
Q
D
L
L
---
S
G
L
H
A
R
Y
V
E
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
I
A
S
S
L
M
K
Q
A
--
G
D
F
-----
S
E
S
H
-
E
M
-
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
K
N
M
5
PsiBlast_PDB
87.52
27%
-105
- C2 -
3B1F
1
?
A:
[11-287]
----
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
H
P
H
Y
K
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
-
E
-
A
---
T
--
A
D
F
K
--
V
--
F
-----
A
-
A
LA
D
V
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
-
L
DL
K
E
D
V
I
I
T
D
A
G
S
T
K
----
Y
E
I
V
R
A
A
-
E
Y
Y
L
---
K
D
KP
V
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
-----
F
S
P
S
C
L
T
K
P
--------
N
T
I
P
A
L
Q
D
L
L
---
S
G
L
H
A
R
Y
V
E
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
----
I
A
S
S
L
--
M
K
Q
A
G
D
F
S
E
-
S
H
-
E
M
-
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
K
N
M
32
HHSearch
79.74
23%
-88
- C2 -
3KTD
2
?
A:
[9-290]
R
P
V
C
I
L
G
L
G
L
I
G
G
S
L
L
R
D
L
H
A
A
N
--
H
S
V
F
G
Y
N
R
S
R
S
G
A
K
S
A
V
D
E
G
F
D
V
-
S
-
A
D
L
E
A
--
T
L
Q
R
A
-
A
--
A
-----
E
-
D
--
A
L
I
V
L
A
V
P
M
T
A
I
D
S
L
L
D
A
V
H
T
H
A
---
P
N
N
G
F
T
D
V
V
S
V
K
----
T
A
V
Y
D
A
V
-
K
A
R
N
M--
Q
H
---
R
Y
V
G
S
H
P
M
A
G
T
A
-
S
G
W
S
A
S
M
D
G
L
F
K
R
A
V
W
V
-----
V
T
F
D
Q
L
F
D
G
TDIN
S
T
W
I
S
I
W
K
D
V
V
Q
M
A
---
L
A
V
G
A
E
V
V
P
S
R
V
G
P
H
D
A
A
A
A
R
V
S
H
L
T
H
I
L
A
E
T
L
A
I
V
G
--
D
N
--------
G
G
-
A
L
-
S
L
S
L
A
A
G
S
Y
R
D
S
T
R
V
A
G
T
D
P
G
L
V
R
A
M
C
E
S
N
A
G
P
L
V
K
A
L
D
E
A
L
A
I
L
H
E
A
R
E
G
L
T
A
E
Q
-
P
N
I
E
Q
L
A
D
N
G
Y
R
S
R
I
R
Y
7
PsiBlast_PDB
71.48
24%
-74
- C2 -
4WJI
6
?
A:
[9-284]
----
L
I
G
I
G
L
I
G
S
S
I
A
R
D
I
R
E
K
Q
L
A
G
T
I
V
V
T
T
R
S
E
A
T
L
K
R
A
G
E
L
G
L
G
D
-
R
-
Y
---
T
LS
A
A
E
A
--
V
--
E
-----
G
-
A
--
D
L
V
V
V
S
V
P
V
G
A
S
G
A
V
A
A
E
I
A
A
H
L
--
K
P
G
A
I
V
T
D
V
G
S
T
K
G
S
V
I
A
Q
M
A
P
H
L
-
P
K
D
V
--------
H
F
V
P
G
H
P
I
A
G
T
E
H
S
G
P
D
A
G
F
A
G
L
F
R
G
R
W
C
I
-----
L
T
P
P
A
G
T
D
E
--------
E
A
V
A
R
L
R
L
F
W
---
E
T
L
G
S
M
V
D
E
M
D
P
K
H
H
D
K
V
L
A
I
V
S
H
L
P
H
I
I
A
Y
N
I
V
G
T
A
D
D
L
E
T
-----
V
-
T
E
-
S
E
-
V
I
K
Y
S
A
S
G
F
R
D
F
T
R
L
A
A
S
D
P
T
M
W
R
D
V
C
L
H
N
K
D
A
I
L
E
M
L
A
R
F
S
E
D
L
A
S
L
Q
R
A
I
R
W
G
D
G
D
K
L
F
D
L
F
T
R
T
R
A
I
R
R
S
I
6
PsiBlast_PDB
69.97
29%
-52
- C2 -
3DZB
-
?
A:
[8-281]
----
I
A
G
L
G
L
I
G
G
S
L
A
L
G
I
K
R
D
H
P
D
Y
E
I
L
G
Y
N
R
S
D
Y
S
R
N
I
A
L
E
R
G
I
V
D
-
R
-
A
---
T
G-
D
F
K
E
--
F
--
A
-----
P
L
A
--
D
V
I
I
L
A
V
P
I
K
Q
T
M
A
Y
L
K
E
L
A
D
-
L
DL
K
D
N
V
I
I
T
D
A
G
S
T
K
----
R
E
I
V
E
A
A
-
E
R
Y
L
---
T
G
K
N
V
Q
F
V
G
S
H
P
M
A
G
S
------
A
A
D
V
T
L
F
E
N
A
Y
Y
I
-----
F
T
P
T
S
L
T
K
E
--------
T
T
I
P
E
L
K
D
I
L
---
S
G
L
K
S
R
Y
V
E
I
D
A
A
E
H
D
R
V
T
S
Q
I
S
H
F
P
H
L
L
A
S
G
L
M
E
Q
A
--
A
D
Y
-----
A
-
Q
A
H
E
M
-
T
N
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
A
S
I
L
M
T
N
G
P
A
V
L
D
R
I
E
D
F
K
K
R
L
D
H
V
A
D
L
I
K
A
E
D
E
S
A
I
W
E
F
F
D
N
G
R
K
K
R
K
E
M
8
PsiBlast_PDB
64.50
25%
-75
- C2 -
3KTD
2
?
A:
[33-259]
--------------------------
S
V
F
G
Y
N
R
S
R
S
G
A
K
S
A
V
D
E
G
F
-
D
-
V
-
S
---
A
--
D
L
E
A
--
T
--
L
Q
R
A
A
A
E
-
D
--
A
L
I
V
L
A
V
P
M
T
A
I
D
S
L
L
D
A
V
H
T
-
H
--
A
P
N
N
G
F
T
D
V
V
S
V
K
----
T
A
V
Y
D
A
V
K
A
R
N
M
---
Q
H
---
R
Y
V
G
S
H
P
M
A
G
T
A
-
S
G
W
S
A
S
M
D
G
L
F
K
R
A
V
W
V
V
T
F
DQ
L
F
D
G
T
D
I
N
S
--------
T
W
I
S
I
W
K
D
V
V
Q
M
A
L
A
V
G
A
E
V
V
P
S
R
V
G
P
H
D
A
A
A
A
R
V
S
H
L
T
H
I
L
A
E
T
L
A
--
I
--
V
G
D
-----
N
-
G
G
-
A
L
-
S
L
S
L
A
A
G
S
Y
R
D
S
T
R
V
A
G
T
D
P
G
L
V
R
A
M
C
E
S
N
A
G
P
L
V
K
A
L
D
E
A
L
A
I
L
H
E
A
R
E
G
L
T
A
E
Q
P
N
I
E
Q
L
A
D
N
G
Y
R
S
R
I
R
Y
E