@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0179: (2016-03-12 )
MVGMTRKKTLFWLCIFLLPNLLGFLIFIAIPILGSLGISFTDWDLVSTIHFTGFENYKRLFNDPEFWKSFRNTITFIIGYLPSVMILGLACALMLNQKIKLRPFFRAVYFLPVITSWVAVSLVWKWLFNPSYGLINYFLSLIGIAGPNWLTDPQTAMIAVIITSAWKDIGFVMVLFLGGLQNISPSYYEAANMDGASKLRQLFSITIPLLTPTTFFVTIISLINSFQVFDQVMIMTEGGPSGATMTLVQNIYNHAFRYFEMGYASAMSWILFIVIFIITIIQNKLQKRWSNY
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40-.......-..50------........60....----....70.----....--...80........90......--.-.100.......110-.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220......-.230.......--------240-------........250-------......---..---260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVGMTRK
K
T
L
F
W
L
C
I
F
L
L
P
N
L
L
G
F
L
I
F
I
A
I
P
I
L
G
SLGISF--TD
W
D
L
V
S
-
T
I
H
F------T
G
F
E
N
Y
K
R
LFN
D
P
E
----
F
W
K
S
F
R
N
----
T
I
T
F
--
I
I
G
Y
L
P
S
V
M
I
L
G
L
A
C
A
L
M
LNQ--K-IK
L
R
P
F
F
R
A
V
Y
F
L
P
-
V
I
T
S
W
V
A
V
S
L
V
W
K
W
LFNP
S
Y
G
L
I
N
Y
F
L
S
L
-IGIAGPNWLTDPQ
T
A
M
I
A
V
I
I
T
S
A
W
K
D
I
G
F
V
M
V
L
F
L
G
G
LQNI
S
P
S
Y
Y
E
AANMD
G
A
S
K
L
R
Q
L
F
S
I
TIPLLT
P
T
T
F
F
V
T
I
I
S
L
I
N
S
F
Q
V
-
F
D
Q
V
M
I
M
TEGG--------PS--------
G
A
T
M
T
L
V
Q
N
I
--------
Y
N
H
A
F
R
---
Y
F
---
E
M
G
Y
A
S
A
M
S
W
I
L
F
I
V
I
F
I
I
T
I
I
Q
N
K
L
Q
K
R
WSNY
8
PsiBlast_PDB
92.98
31%
-147
- C4 -
3RLF
2
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
11
PsiBlast_PDB
92.31
31%
-144
- C4 -
4KI0
5
MALF_ECOLI
F:
[259-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
N
----------
6
PsiBlast_PDB
91.95
31%
-145
- C4 -
3PUW
3
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
2
PsiBlast_PDB
91.89
31%
-148
- C4 -
3PUY
2
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
7
PsiBlast_PDB
91.70
31%
-147
- C4 -
3PUX
3
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
21
HHSearch
91.64
31%
-139
- C4 -
3RLF
2
MALF_ECOLI
F:
[257-503]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
IQKP
F
L
A
I
F
V
W
----
T
V
V
F
--
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E-
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
-
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
L
F
G
V
K
-
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
--------
P
D
RLGTTTPA
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
GGG
G
Q
---
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
5
PsiBlast_PDB
91.58
31%
-145
- C4 -
3PUV
3
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
9
PsiBlast_PDB
90.55
31%
-142
- C4 -
4JBW
1
MALF_ECOLI
F:
[259-509]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
N
L
K
A
T
------
3
PsiBlast_PDB
90.36
31%
-137
- C4 -
3PUZ
2
MALF_ECOLI
F:
[259-503]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------
29
Fugue
90.25
27%
-138
- C4 -
2R6G
1
MALF_ECOLI
F:
[13-504]
DALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKTYNFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKETTAQPEGERANLRVITQNRQALSDITAILPDGNKVMMSSLRQF
S
G
T
Q
P
L
Y
T
L
D
G
D
G
T
L
T
N
N
Q
S
G
V
K
Y
R
P
N
N
Q
I
G
F
Y
Q
S
I
T
A
N
W
--
G
D
E
K
L
S
P
G
Y
T
V
T
------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
IQKP
F
L
A
I
F
V
W
----
T
V
V
F
--
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
--
E
A
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
-
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
--------
P
D
RLGTTTPA
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
-----------
1
PsiBlast_PDB
90.10
31%
-149
- C4 -
2R6G
1
MALF_ECOLI
F:
[259-504]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
-----------
4
PsiBlast_PDB
90.05
31%
-137
- C4 -
3PV0
2
MALF_ECOLI
F:
[259-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
N
----------
10
PsiBlast_PDB
90.00
31%
-139
- C4 -
4KHZ
2
MALF_ECOLI
F:
[259-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
T
D
E
G
----
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
N
----------
18
PsiBlast_CBE
89.66
31%
-147
- C4 -
4JBW
1
MALF_ECOLI
H:
[259-509]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
W
K
N
F
T
R
V
F
--------
I
Q
K
P
F
L
A
IFVW
T
V
V
F
SL
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
-
L
V
Q
W
E
--
A
-
L
R
G
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
-
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
-
L
F
G
V
K
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTT
P
A
--------
G
Y
T
D
L
L
V
N
Y
T
--------
Y
R
I
A
F
E
---
G
G
GGQ
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
N
L
K
A
T
------
13
PsiBlast_PDB
88.66
26%
-131
- C4 -
4TQV
-
?
A:
[14-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
A
M
L
L
P
T
I
I
W
F
L
I
F
L
Y
K
P
M
I
G
-
L
Q
M
A
F
KQ----------
P
W
------
I
G
F
D
H
F
V
T
L
F
Q
S
E
Q
----
F
I
R
A
I
K
N
----
T
L
T
L
--
S
G
L
S
L
L
F
G
F
P
M
P
I
L
L
A
L
M
I
N
E
VY
S
-
K
G
Y
R
K
A
V
Q
T
I
V
Y
L
P
-
H
F
I
S
I
V
I
V
A
G
L
V
V
T
F
L
S
P
S
T
G
V
V
N
N
M
L
S
W
-
I
G
L
D
R
V
Y
F
L
T
Q
P
E
W
F
R
P
I
Y
I
S
S
N
I
W
K
E
A
G
F
D
S
I
V
Y
L
A
A
I
M
S
I
N
P
A
L
Y
E
S
A
Q
V
D
G
A
T
R
W
Q
M
I
T
R
I
T
L
P
C
I
V
P
T
I
A
V
L
L
V
I
R
L
G
H
I
L
E
V
G
F
E
Y
I
I
L
L
Y
Q
P
T
--------
T
Y
--------
E
T
A
D
V
I
S
T
Y
I
--------
Y
R
L
G
L
Q
---
G
A
---
R
Y
D
I
A
T
A
A
G
I
F
N
A
V
V
A
L
V
I
V
L
F
A
N
H
M
S
R
R
----
12
PsiBlast_PDB
88.14
26%
-135
- C4 -
4TQU
-
?
M:
[14-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
A
M
L
L
P
T
I
I
W
F
L
I
F
L
Y
K
P
M
I
G
-
L
Q
M
A
F
------------
P
W
------
I
G
F
D
H
F
V
T
L
F
Q
S
E
Q
----
F
I
R
A
I
K
N
----
T
L
T
L
--
S
G
L
S
L
L
F
G
F
P
M
P
I
L
L
A
L
M
I
N
E
VY
S
-
K
G
Y
R
K
A
V
Q
T
I
V
Y
L
P
-
H
F
I
S
I
V
I
V
A
G
L
V
V
T
F
L
S
P
S
T
G
V
V
N
N
M
L
S
W
-
I
G
L
D
R
V
Y
F
L
T
Q
P
E
W
F
R
P
I
Y
I
S
S
N
I
W
K
E
A
G
F
D
S
I
V
Y
L
A
A
I
M
S
I
N
P
A
L
Y
E
S
A
Q
V
D
G
A
T
R
W
Q
M
I
T
R
I
T
L
P
C
I
V
P
T
I
A
V
L
L
V
I
R
L
G
H
I
L
E
V
G
F
E
Y
I
I
L
L
Y
Q
P
T
--------
T
Y
--------
E
T
A
D
V
I
S
T
Y
I
--------
Y
R
L
G
L
Q
---
G
A
---
R
Y
D
I
A
T
A
A
G
I
F
N
A
V
V
A
L
V
I
V
L
F
A
N
H
M
S
R
R
----
19
HHSearch
80.40
17%
-140
- C4 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
--
F
------------------
N
F
D
E
F
L
K
A
A
S
D
P
A
----
V
W
K
V
V
L
T
----
T
Y
Y
A
--
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K-
S
-
F
P
G
K
S
V
V
E
G
I
V
D
L
P
-
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
L
I
G
S
F
S
P
-------
L
K
F
V
----
D
A
L
P
G
I
V
V
A
M
L
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
-
F
G
A
V
V
V
I
A
Y
-
Y
--------
P
------------
M
I
A
P
T
L
I
--------
Y
E
R
Y
-
L
---
S
E
---
G
L
S
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
-----
30
Fugue
78.98
15%
-125
- C4 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
--
L
P
V
A
A
T
V
-
T
L
Q
L
------
F
N
F
D
E
F
L
K
A
A
S
D
P
A
----
V
W
K
V
V
L
T
----
T
Y
Y
A
--
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K-
S
-
F
P
G
K
S
V
V
E
G
I
V
D
L
P
-
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
F
G
S
S
------------
G
L
I
G
S
F
S
P
L
K
F
V
D
A
L
P
G
I
V
V
A
M
L
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
-
F
G
A
V
V
V
I
A
-----------
Y
Y
--------
P
M
I
A
P
T
L
I
Y
E
--------
R
Y
L
S
E
G
---
L
S
---
A
---
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
-----
31
Fugue
74.77
19%
-134
- C4 -
4TQU
-
?
N:
[2-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
T
P
F
Y
S
R
S
D
R
I
F
G
I
V
N
A
V
L
L
G
I
F
A
L
C
A
L
Y
P
I
I
Y
I
F
S
M
S
I
--
S
S
G
A
A
V
T
-
Q
G
R
V
FLLPVD
I
D
F
S
A
Y
G
R
V
L
H
D
K
L
----
F
W
T
S
Y
A
N
----
T
I
F
Y
T-
V
F
G
V
V
T
S
L
I
F
I
V
P
G
A
Y
A
L
S
K
P
--
R
-
I
R
G
R
R
V
F
G
F
I
I
A
F
T
-
M
W
F
N
A
---------------
G
M
I
P
F
F
L
N
M
-
R
D
L
----
G
L
L
D
N
R
F
G
I
L
I
G
F
A
C
N
-----
A
F
N
I
I
L
M
R
N
Y
F
E
S
I
S
A
S
F
E
E
A
A
R
M
D
G
A
N
D
L
Q
I
L
W
K
V
Y
I
P
L
A
K
P
A
L
A
T
I
T
L
L
C
A
I
S
R
W
N
G
-
Y
F
W
A
M
V
L
L
R
A
E
--------
E
K
--------
I
P
L
Q
V
Y
L
K
K
T
IVDLNVNE
E
F
A
G
A
L
---
L
T
---
N
S
Y
S
M
E
T
V
V
G
A
I
I
V
M
S
I
I
P
V
I
I
V
Y
P
V
V
Q
K
Y
F
T
K
20
HHSearch
72.39
17%
-131
- C4 -
3D31
-
?
C:
[44-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
L
V
L
F
L
F
I
F
L
T
L
S
N
M
I
F
E
Q
I
--
T
E
-----------------
D
F
S
G
L
V
K
A
A
G
N
R
S
----
V
I
S
S
I
F
L
----
S
L
Y
A
--
G
F
L
A
T
L
L
A
L
L
L
G
A
P
T
G
Y
I
L
A
R
F-
D
-
F
P
G
K
R
L
V
E
S
I
I
D
V
P
-
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
F
G
S
-
R
G
L
I
G
E
P
L
E
S
-
Y
I
----
Q
F
----
R
D
A
L
P
G
I
V
V
A
M
L
F
V
S
M
P
Y
L
A
N
S
A
R
E
G
F
K
S
V
D
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
W
A
R
A
I
S
E
-
F
G
A
V
V
I
L
A
Y
-
Y
--------
P
------------
M
V
G
P
T
L
I
--------
Y
D
R
F
-
I
---
S
Y
---
G
L
S
A
S
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
L
V
I
R
---------