@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0205: (2016-03-13 )
MKFKKVVLGMCLIASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40.....----...50......----------------..60.--.......70........80-----.-----...----.-...90..---......100.......110.-.---.....120...------....130---------.-------..---.--------.---....140------------.......150----------------.--......160........170.......180....-.----------..190.......200....--.-------.---------.210---..---------------.-------.-.--.----.220.......230....-...240------.......250.------......260.......270.....-------..280.......-------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
F
K
K
V
V
L
G
M
C
L
I
A
S
V
L
V
F
P
V
T
I
KA
N
A
C
C
D
E
Y
LQTPAAPHD
I
D
SKL----PH
K
L
SWSADNP----------------TNTDV--N
T
H
Y
W
L
F
K
Q
A
E
K
I
L
A
K
D
V
N
-----
H
-----
M
R
A
----
N
-
L
M
N
E
L
K
K
---
F
D
K
Q
I
A
Q
G
I
YDADHKNPYY
D
-
T
---
S
T
F
L
S
HFYNPD------RDNTY-----------L-------PG---F--------A---N
A
K
I
T
G
A
------------
K
Y
F
N
QSV
T
D
Y----------------R--EGKF
D
T
A
-
F
Y
K
L
G
L
A
I
H
Y
YTDISQPMHANN
F
T
A
I-S----------YPPGY
H
C
A
Y
E
N
Y
V
D
T
I
K
HN--Y-------Q---------
A
T
E
D
---
M
V
---------------
A
-------
K
-
R
--
F
----
C
S
D
D
V
K
D
W
L
Y
E
N
A
K
RAKA-DYPKIV------NAKT
K
K
S
Y
L
VG------NSEWKKDTVEPT
G
A
RLR
D
S
Q
Q
T
L
A
-------
G
F
L
E
F
W
S
KKTNE-------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.92
39%
-51
- C6 -
2HUC
3
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
G
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
D
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
96.82
39%
-44
- C6 -
1AH7
3
PHLC_BACCE
A:
[1-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
D
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
F
D
T
Y
G
D
-------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.18
39%
-49
- C6 -
1AH7
3
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
D
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.97
39%
-52
- C6 -
1P5X
3
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
N
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.84
39%
-49
- C6 -
1P6E
4
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
N
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.25
39%
-49
- C6 -
2FGN
3
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
D
T
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.18
39%
-50
- C6 -
1P6D
4
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
E
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
N
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.36
39%
-49
- C6 -
2FFZ
3
PHLC_BACCE
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
A
Q
D
K
----------------
H
K
E
G
V
--
N
S
H
L
W
I
V
N
R
A
I
D
I
M
S
R
N
T
T
-----
L
-----
V
K
Q
----
D
-
R
V
A
Q
L
N
E
---
W
R
T
E
L
E
N
G
I
Y
A
A
D
Y
E
N
P
Y
Y
D
-
N
---
S
T
F
A
S
H
F
Y
D
P
D
------
N
G
K
T
Y
-----------
I
-------
P
F
---
A
--------
K
---
Q
A
K
E
T
G
A
------------
K
Y
F
K
L
A
G
E
S
Y
----------------
K
--
N
K
D
M
K
Q
A
-
F
F
Y
L
G
L
S
L
H
Y
L
G
D
V
N
Q
P
M
H
A
A
N
F
T
N
L
-
S
----------
Y
P
Q
G
F
H
S
K
Y
E
N
F
V
D
T
I
K
D
N
--
Y
-------
K
---------
V
T
D
G
---
N
G
---------------
Y
-------
W
-
N
--
W
----
K
G
T
N
P
E
E
W
I
H
G
A
A
V
V
A
K
Q
-
D
Y
S
G
I
V
------
N
D
N
T
K
D
W
F
V
K
A
AVS
Q
E
Y
A
D
K
W
R
A
E
V
T
P
M
T
G
K
R
L
M
D
A
Q
R
V
T
A
-------
G
Y
I
Q
L
W
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.07
25%
-65
- C6 -
1GYG
2
PHLC1_CLOPE
A:
[8-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
T
D
N
N
F
S
KDNSWYLA
Y
S
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
------------
S
A
G
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
KINTVGC
K
---------
T
N
E
D
---
F
Y
---------------
A
-------
D
-
I
--
L
----
K
N
K
D
F
N
A
W
S
K
E
Y
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
67.13
23%
-25
* C6 *
1OLP
3
?
A:
[3-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
K
E
D
G
T
--
G
T
H
S
V
I
V
T
Q
A
I
E
M
L
K
H
D
L
S
-----
K
-----
D
E
P
E
A
I
R
N
-
D
L
S
I
L
E
K
---
N
L
H
K
F
Q
L
G
S
T
F
P
D
Y
D
P
N
A
---
Y
---
S
L
Y
Q
D
H
F
W
D
P
D
------
T
D
H
N
F
-----------
T
QDNKWYL
S
Y
AV-
P
--------
D
---
N
A
E
S
Q
T
R
------------
K
F
A
T
L
A
K
N
E
W
----------------
D
--
K
G
N
Y
E
K
A
-
A
W
Y
L
G
Q
G
M
H
Y
F
G
D
L
N
T
P
Y
H
A
A
N
V
T
A
V
-
D
------------
S
P
G
H
V
K
F
E
T
Y
A
E
E
R
K
D
T
--
Y
-------
R
---------
L
D
T
T
---
G
Y
---------------
N
TDD
A
F
Y
-
K
D
T
--
L
KNDN
F
N
E
W
S
K
G
Y
C
K
Y
W
A
K
K
A
K
N
-
L
Y
Y
S
H
A
------
T
M
S
N
S
W
----------------
D
D
W
E
Y
A
A
S
H
G
V
G
N
A
Q
K
G
V
A
-------
G
Y
L
Y
R
F
L
N
D
V
S
--------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.69
25%
-58
- C6 -
1CA1
9
PHLC1_CLOPE
A:
[8-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
T
D
N
N
F
SKDNSWYLA
Y
S
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
------------
S
A
G
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
KINTVGC
K
---------
T
N
E
D
---
F
Y
---------------
A
-------
D
-
I
--
L
----
K
N
K
D
F
N
A
W
S
K
E
Y
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.56
25%
-56
- C6 -
1QMD
2
PHLC1_CLOPE (first)
A:
[8-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
T
D
N
N
F
S
KDNSWYLA
Y
S
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
----------
S
A
G
--
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.07
25%
-58
- C6 -
1QM6
2
PHLC1_CLOPE (first)
A:
[8-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
T
D
N
N
F
S
KDNSWYLAY
S
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
----------
S
A
G
--
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.60
25%
-54
- C6 -
2WY6
4
PHLC_CLOP1
A:
[8-166]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
I
D
N
--
S
W
Y
L
A
Y
S
----
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
------------
S
A
G
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.22
25%
-53
- C6 -
2WXU
4
PHLC_CLOP1
A:
[8-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
V
T
Q
G
V
S
I
L
E
N
D
L
S
KNEP
E
S
-----
V
R
K
----
N
-
L
-
E
I
L
K
E
---
N
M
H
E
L
Q
L
G
S
T
Y
P
D
Y
D
K
N
A
Y
D
-
L
-----
Y
Q
D
H
F
W
D
P
D
------
I
----WYLA
Y
S
-----
I
-------
P
D
---
T
--------
G
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
Q
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
I
D
T
P
Y
H
P
A
N
V
T
A
V
-
D
------------
S
A
G
H
V
K
F
E
T
F
A
E
E
R
K
E
Q
--
Y
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
54.82
14%
-34
- C6 -
4EEI
12
?
A:
[1-433]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIKRYDV
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
R
M
V
P
-
K
G
T
A
A
E
I
R
A
R
A
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
----
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
F
TAETGKFFHFGV
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
-----
A
-----
L
C
D
----
S
-
L
L
T
K
A
E
E
---
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
-
G
---
Q
K
F
L
G
A
Y
V
E
F
K
------
R
R
L
K
D
-----------
L
-------
K
D
---
F
--------
Q
---
K
D
G
L
T
V
Q
FSGAVGNYCILT
T
E
D
E
K
K
A
A
D
I
L
GLPVEEVSTQVIPR
D
R
--
I
A
K
L
I
S
I
-
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
----------
G
F
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
--
R
-------
S
---------
H
V
S
I
---
A
L
E
N
C
VLWHERDI
S
H
S
S
A
-------
E
-
R
--
F
----
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
-
T
I
D
N
L
V
VQ
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
------
S
S
F
Y
L
H
F
L
V
A
N
T
P
F
M
R
E
D
C
Y
K
I
V
Q
Q
VES
F
S
K
K
L
Q
K
V
M
H
D
E
H
N
I
I
L
D
I
P
EMD
F
E
G
I
K
K
T
YLKE
I
D
H
V
F
D
R
S
V
KAR------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.68
26%
-32
- C6 -
1OLP
3
?
A:
[8-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
S
V
I
V
T
Q
A
I
E
M
L
K
H
D
L
S
-----
K
-----
D
E
P
----
E
A
I
R
N
D
L
S
I
---
L
E
K
N
L
H
K
--
F
Q
L
G
S
T
F
P
D
Y
D
-
P
NAY
S
L
Y
Q
D
H
F
W
D
P
D
TDHNFT
Q
D
N
K
W
-----------
Y
-------
L
S
---
Y
--------
A
VPD
N
A
E
S
Q
T
R
------------
K
F
A
T
L
A
K
N
E
W
----------------
D
--
K
G
N
Y
E
K
A
-
A
W
Y
L
G
Q
G
M
H
Y
F
G
D
L
N
T
P
Y
H
A
A
N
V
T
A
V
-
D
----------
S
P
G
--
H
V
K
F
E
T
Y
A
E
E
R
K
D
T
--
Y
-------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.91
28%
-40
- C6 -
1KHO
3
PHLC_CLOPF
A:
[8-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
G
T
H
A
M
I
A
T
Q
G
V
T
I
L
E
N
D
L
S
-----
S
NEP
E
V
I
R
N
----
N
-
L
--
E
I
L
K
Q
N
M
H
D
L
Q
L
G
S
T
Y
P
D
Y
D
-
K
N
A
Y
-------
D
L
Y
Q
D
H
F
W
D
P
D
------
T
D
N
N
F
TKDSKWYLS
Y
S
I
-------
P
D
---
T
--------
A
---
E
S
Q
I
R
--------------
K
F
S
A
L
A
R
Y
E
W
----------------
K
--
R
G
N
Y
K
Q
A
-
T
F
Y
L
G
E
A
M
H
Y
F
G
D
A
D
T
P
Y
H
A
A
N
V
T
A
V
-
D
----------
S
P
G
--
H
V
K
F
E
T
F
A
E
D
R
K
D
Q
--
Y
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
51.80
16%
-38
- C6 -
4ZUZ
-
?
A:
[7-863]
D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGDE
I
G
L
D
N
TC
Q
T
A
V
E
L
I
T
F
F
YGSAHSGVTKYS
A
E
H
Q
L
S
E
Y
K
R
Q
L
E
E
D
I
K
A
I
N
S
Q
KKISPHAY
D
D
L
L
K
E
K
I
E
R
L
Q
Q
I
E
K
Y
I
E
L
I
Q
V
L
K
K
QYDEQN
D
I
R
Q
L
R
TGGIPQLP
S
G
V
K
E
I
I
K
S
SEN
A
F
A
V
R
L
S
P
YDNDKFTRFDDPL
F
N
V
K
R
N
ISKYDTPSRQ
A
P
I
P
I
YEG
L
G
Y
R
L
R
S
T
L
FPEDK
T
P
T
P
I
N
K
K
S
L
R
D
K
V
K
S
T
V
L
S
HYKDEDRIDGEK
K
D
E
K
L
N
E
L
I
T
N
L
Q
N
E
L
V
K
E
L
V
K
S
DPQYSKLSLSKDPRG
K
E
I
N
YDYLVNSLMLVDNDSE
I
G
D
W
I
D
T
I
L
D
A
T
VDSTVWAVQASSPFYQGAKEISS
D
R
D
A
D
K
I
S
I
R
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
KLSDAN
F
G
E
F
F
D
KE
P
H
A
T
E
I
A
K
R
V
K
E
G
F
T
Q
GAD
I
E
P
I
I
Y
D
Y
I
N
S
NHAELGLKSPLT
G
K
Q
Q
Q
E
I
T
D
K
F
T
K
H
Y
N
T
I
K
ESPHFD
E
F
F
V
A
D
PDKKGN
I
F
S
H
QGRISCH
F
L
D
F
F
T
R
Q
T
KGK
H
P
L
G
D
L
A
S
H
Q
E
A
L
Q
E
G
T
S
N
R
L
H
H
K
N
E
V
V
A
Q
G
Y
E
K
L
D
Q
F
K
K
E
V
V
K
L
L
A
E
NK
P
K
E
L
L
D
Y
L
V
A
T
----------------
S
P
T
G
V
--
P
N
Y
S
M
L
S
K
E
T
Q
N
Y
I
A
Y
--
N
-----
R
-----
N
W
P
----
A
-
I
Q
K
E
L
E
K
--------
A
T
S
I
----
P
E
S
Q
K
Q
D
-
L
---
S
R
L
L
S
------------
R
D
N
L
Q
-----------
H
-------
D
N
---
L
--------
S
-----
A
I
T
W
S
------------
K
Y
S
S
K
P
L
-------------------------
L
D
V
E
-
L
N
K
I
A
E
G
L
E
L
T
A
K
I
Y
N
E
K
R
G
R
E
W
----
W
----------
F
A
G
S
R
N
E
A
R
K
T
Q
C
E
E
L
Q
R
V
--
S
-------
K
---------
E
I
N
T
---
L
L
---------------
Q
-------
S
-
E
--
S
----
L
T
---
K
S
Q
V
L
E
K
V
L
N
S
I
E
-
T
L
D
K
I
D
------
R
D
I
S
A
E
S
------------
N
W
F
Q
S
T
L
Q
K
E
V
R
L
F
R
D
Q
L
K
D
I
C
-------
Q
L
D
K
Y
Y
F
K
S
T
K
L
D
E
I
I
S
L
E
M
E
E
Q
F
Q
K
IQD
P
A
V
Q
Q
I
V
R
D
LPSHCHN
D
E
A
I
E
F
F
K
T
L
N
P
E
E
A
A
K
V
A
S
Y
L
S
L
E
Y
R
E
I
N
KSTDK
K
T
L
L
E
Q
D
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
KAID
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T
23
HHSearch
48.80
15%
-26
- C6 -
3SNG
9
?
A:
[5-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
V
M
T
C
R
I
A
Q
G
L
L
N
D
E
A
A
-----
H
--------------
A
V
K
M
L
L
P
EY-
V
N
G
D
L
S
A
L
C
V
W
P
D
Q
V
R
H
W
Y
K
Y
K
---
W
T
S
P
L
H
F
I
D
T
P
------
D
K
A
C
N
-----------
F
-------
D
Y
ERD
C
HDQHGVKD
M
---
C
V
A
G
A
I
Q
------------
N
F
T
T
Q
L
S
H
-
Y
----------------
R
EG
T
S
D
R
R
Y
N
M
T
E
A
L
L
F
L
S
H
F
M
G
D
I
H
Q
P
M
H
V
G
F
T
S
D
A
-
G
GNS
I
D
L
R
W
FR
H
K
S
N
L
H
H
V
W
D
R
E
I
I
L
T
A
A
K
D
Y
Y
-------
A
KD
I
N
L
L
E
E
D
I
E
G
N
F
T
D
G
I
---------------
W
SDD
L
A
S
W
R
-
E
CG
N
----
V
F
S
C
V
N
K
F
A
T
E
S
I
N
I
A
C
K
W
G
Y
K
G
V
E
-------
A
G
E
T
L
-----------
S
D
D
Y
F
N
S
R
L
P
I
V
M
K
R
V
A
Q
G
G
I
R
L
A
-------
M
L
L
N
N
V
F
G
A
----------------------------------------------------------------------------------------------------------------------------------