@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1667: (2016-03-27 )
LKRKVGIIGTGHVGSDVAFSLVTQGICDEIVLIDKIETKAESEALELRDMASMTNSYTMITSNDWSALGDADVIVMAVGPETLLREDRMEELVETSRSVAEIVPKIIASGFQGIFVNITNPCDVITMLIQKLSGFDHSRVFGTGTSLDTARMRRVVGEALHINPKSVEGYVLGEHGESQFVAWSTVKIGGVSIKDYKTTTSLDLPALKDAVRGGGWNILTGKGWTSFGIATAVAGIVDAILTDAKQVFPLAVFSEKTSTYIGQPALIGANGVIDILEPPLTETEKINFNESAEIIKNAFQLI
Atome Classification :
(28 SA)
.........10........20........30........40........50........60......-..70........80..--...-...90........100........110.......120.......130.......140.......150.......160.......170.......180.......190.-----...-----...200---...-...-----...210.......220.......230.......240.......----250...----.----.----.----.260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LK
R
K
V
G
I
I
GTGHV
G
S
D
V
A
F
S
L
V
T
QGICD
E
I
V
L
I
D
KIETKAE
S
E
A
L
E
L
R
D
M
A
SMTN
S
Y
T
M
I
TSNDWSA-LGDA
D
V
I
V
M
AV
G
P
E
T
L
--
L
R
E
-
D
R
M
E
E
L
V
E
T
S
R
S
V
A
-
E
I
V
P
K
I
I
A
SGF
Q
G
I
F
V
NIT
N
P
C
D
V
I
T
M
L
I
Q
K
LSGFDHS
R
V
FGTGTSL
D
T
A
R
M
R
R
V
V
G
E
ALHINPKSV
E
G
Y
V
LGEHGES
Q
F
V
A
W
S
T
V
K
I
G
G
V
S
I
-----
K
DY-----KTTT-----SLD-
L
P
A
-----
L
K
D
A
V
RGGG
W
N
I
LTGKGWTS
F
G
I
A
T
A
V
A
G
I
V
D
A
I
L
T
D
A
K
Q
V
F
P
----
L
A
V
FSE----K----T----S----TYIGQP
A
L
IGAN
G
V
I
D
ILEPPLTETEKINFN
E
S
A
E
I
I
K
N
A
F
QLI
21
PsiBlast_CBE
94.90
41%
-118
- C2 -
1HYH
2
DHL2_WEICO
D:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
-
L
A
D
A
D
V
V
I
S
T
L
G
---------G
D
R
F
A
E
L
K
F
T
S
S
M
V
Q
-
S
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
-----
V
T
L
-----
A
D
A
-------
I
D
-
L
A
A
-----
I
E
E
E
A
R
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
----
V
S
N
R
R
D
----
D
----
M
----
G
----
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
22
PsiBlast_CBE
94.72
41%
-117
- C2 -
1HYH
2
DHL2_WEICO
C:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
-
L
A
D
A
D
V
V
I
S
T
L
G
---------G
D
R
F
A
E
L
K
F
T
S
S
M
V
Q
-
S
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
-----
V
T
L
-----
A
D
A
-------
I
D
-
L
A
A
-----
I
E
E
E
A
R
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
----
V
S
N
R
R
D
----
D
----
M
----
G
----
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
114
HHSearch
94.66
42%
-113
- C2 -
1HYH
2
DHL2_WEICO
A:
[1-305]
-
A
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
-
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
QQ------
F
A
E
L
K
F
T
S
S
M
V
Q
-
S
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
-----
V
T
L
---------------
I
D
-
L
A
A
-----
I
E
E
E
A
R
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
----
V
S
N
R
R
D
----
D
----
M
----
G
----
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
1
PsiBlast_PDB
93.66
41%
-113
- C2 -
1HYH
2
DHL2_WEICO
A:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
-
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
--
Q
Q
----
F
A
E
L
K
F
T
S
S
M
V
Q
-
S
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
-----
V
T
L
---------------
I
D
-
L
A
A
-----
I
E
E
E
A
R
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
----
V
S
N
R
R
D
----
D
----
M
----
G
----
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
23
PsiBlast_CBE
92.92
41%
-111
- C2 -
1HYH
2
DHL2_WEICO
B:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
-
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
--
Q
Q
----
F
A
E
L
K
F
T
S
S
M
V
Q
-
S
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
-----
V
T
L
---------------
I
D
-
L
A
A
-----
I
E
E
E
A
R
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
----
V
S
N
R
R
D
----
D
----
M
----
G
----
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
44
PsiBlast_CBE
91.24
38%
-118
- C2 -
2ZQZ
3
LDH_LACCA
D:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
--------
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
AEWV-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
5
PsiBlast_PDB
91.04
38%
-115
- C2 -
2ZQY
4
LDH_LACCA
A:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
G
E
-
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
V
-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
39
PsiBlast_CBE
90.65
38%
-119
- C2 -
3VKV
2
LDH_LACCA
D:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
--------
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
AEWV-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
6
PsiBlast_PDB
90.59
38%
-119
- C2 -
2ZQZ
2
LDH_LACCA
A:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
--------
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
V
-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
34
PsiBlast_CBE
90.11
38%
-123
- C2 -
3VKU
3
LDH_LACCA
D:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
-----------------
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
V
-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
18
PsiBlast_PDB
90.04
33%
-99
- C2 -
2V7P
2
LDH_THET8
A:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
A
E
A
R
G
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
120
HHSearch
89.97
34%
-104
- C2 -
3VPG
-
LDH_THECA
A:
[1-308]
--
M
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
-
P
V
W
V
R
-
A
G
S
Y
G
D
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
-----
A
E
A
R
GRALS
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
EV--
E
GV--
L
----
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
A
F
A
L
7
PsiBlast_PDB
89.90
38%
-116
- C2 -
3VKV
1
LDH_LACCA
A:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
--------
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
V
-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
80
PsiBlast_CBE
89.86
32%
-105
- C2 -
3VPH
5
LDH_THECA
A:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
A
E
A
R
G
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
48
PsiBlast_CBE
89.77
38%
-114
- C2 -
2ZQY
4
LDH_LACCA
C:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
--
P
G
E
-
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
AEWV-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
33
PsiBlast_CBE
89.67
38%
-117
- C2 -
3VKU
3
LDH_LACCA
E:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
--
P
G
E
-
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
V
-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
68
PsiBlast_CBE
89.56
33%
-98
- C2 -
2XXJ
3
LDH_THET8
D:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
W
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
A
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
----
A
GVLE
V
S
L
S
L
P
R
I
L
G
A
G
G
V
A
G
T
V
Y
P
S
L
S
P
E
E
R
A
A
L
R
R
S
A
E
I
L
K
E
A
----
47
PsiBlast_CBE
89.51
38%
-113
- C2 -
2ZQY
4
LDH_LACCA
D:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
S
N
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
-----
G
E
-
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
E
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
AEWV-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
D
A
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
29
PsiBlast_CBE
89.51
38%
-109
- C2 -
3VPF
3
LDH_LACCA
D:
[10-310]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
F
T
-
S
P
K
K
I
Y
S
A
E
Y
S
D
-
A
K
D
A
D
L
V
V
I
T
A
G
A
P
Q
K
--
P
G
E
-
T
R
L
D
L
V
N
K
N
L
K
I
L
K
-
S
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
AEWV-
K
A
H
-----
P
E
I
K
-----
E
D
K
-
L
V
K
-----
M
F
E
D
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
----
L
S
V
Y
M
D
----
G
QYGL
N
----
D
----
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
------
51
PsiBlast_CBE
89.41
36%
-109
- C2 -
3WSW
6
?
C:
[6-307]
--
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
-
C
Q
D
A
N
L
V
I
L
T
A
G
V
N
Q
K
--
P
G
Q
-
T
R
L
D
-
L
V
K
T
N
A
T
I
T
R
Q
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
MEYVE
K
D
H
-----
R
L
E
E
-----
N
-
D
-
L
T
V
-----
L
A
D
K
V
K
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
----
V
S
A
Y
L
N
GEYG
E
----
E
----
D
----
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
------
74
PsiBlast_CBE
88.89
33%
-112
- C2 -
2V7P
2
LDH_THET8
B:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
--------------
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
A
E
A
RG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
70
PsiBlast_CBE
88.16
33%
-96
- C2 -
2XXJ
3
LDH_THET8
B:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
W
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
A
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
----
A
GVLE
V
S
L
S
L
P
R
I
L
G
A
G
G
V
A
G
T
V
Y
P
S
L
S
P
E
E
R
A
A
L
R
R
S
A
E
I
L
K
E
A
----
77
PsiBlast_CBE
87.94
32%
-104
- C2 -
3VPH
5
LDH_THECA
D:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
78
PsiBlast_CBE
87.57
32%
-102
- C2 -
3VPH
4
LDH_THECA
C:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
79
PsiBlast_CBE
87.50
32%
-103
- C2 -
3VPH
5
LDH_THECA
B:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
A
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
H
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
73
PsiBlast_CBE
87.48
33%
-94
- C2 -
2V7P
2
LDH_THET8
C:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
A
Q
R
--
P
G
E
-
T
R
L
Q
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
A
E
A
R
G
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
E
G
V
L
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
72
PsiBlast_CBE
87.36
33%
-108
- C2 -
2V7P
2
LDH_THET8
D:
[2-304]
---
K
V
G
I
V
G
S
G
M
V
G
S
A
T
A
Y
A
L
A
L
L
G
V
A
R
E
V
V
L
V
D
L
D
R
K
L
A
Q
A
H
A
E
D
I
L
H
A
T
P
F
A
H
P
-
V
W
V
R
A
G
S
Y
G
D
-
L
E
G
A
R
A
V
V
L
A
A
G
V
-------------
L
L
D
R
N
A
Q
V
F
A
-
Q
V
V
P
R
V
L
E
A
A
P
E
A
V
L
L
V
A
T
N
P
V
D
V
M
T
Q
V
A
Y
R
L
S
G
L
P
P
G
R
V
V
G
S
G
T
I
L
D
T
A
R
F
R
A
L
L
A
E
Y
L
R
V
A
P
Q
S
V
H
A
Y
V
L
G
E
H
G
D
S
E
V
L
V
W
S
S
A
Q
V
G
G
V
P
L
-----
L
E
F
AEARG
R
A
L
S
-----
P
E
D
-
R
A
R
-----
I
D
E
G
V
R
R
A
A
Y
R
I
I
E
G
K
G
A
T
Y
Y
G
I
G
A
G
L
A
R
L
V
R
A
I
L
T
D
E
K
G
V
Y
T
----
V
S
A
F
T
P
----
E
----
V
EGVL
E
----
V
S
L
S
L
P
R
I
L
G
A
G
G
V
E
G
T
V
Y
P
S
L
S
P
E
E
R
E
A
L
R
R
S
A
E
I
L
K
E
A
----
98
PsiBlast_CBE
83.39
31%
-107
- C2 -
1LTH
3
LDH2_BIFL2
R:
[9-311]
---
K
L
A
V
I
G
A
G
A
V
G
S
T
L
A
F
A
A
A
Q
R
G
I
A
R
E
I
V
L
E
D
I
A
K
E
R
V
E
A
E
V
L
D
M
Q
H
G
S
S
F
Y
P
T
V
S
I
D
G
S
D
D
P
E
I
-
C
R
D
A
D
M
V
V
I
T
A
G
P
R
Q
K
--
P
G
Q
-
S
R
L
E
L
V
G
A
T
V
N
I
L
K
-
A
I
M
P
N
L
V
K
V
A
P
N
A
I
Y
M
L
I
T
N
P
V
D
I
A
T
H
V
A
Q
K
L
T
G
L
P
E
N
Q
I
F
G
S
G
T
N
L
D
S
A
R
L
R
F
L
I
A
Q
Q
T
G
V
N
V
K
N
V
H
A
Y
I
A
G
E
H
G
D
S
E
V
P
L
W
E
S
A
T
I
G
G
V
P
M
-----
S
D
W
-----
T
P
L
P
-----
G
H
D
P
L
D
A
DKREE
I
H
Q
E
V
K
N
A
A
Y
K
I
I
N
G
K
G
A
T
N
Y
A
I
G
M
S
G
V
D
I
I
E
A
V
L
H
D
T
N
R
I
L
P
VSSM
L
K
D
F
H
G
----
I
----
S
----
D
----
I
C
M
S
V
P
T
L
L
N
R
Q
G
V
N
N
T
I
N
T
P
V
S
D
K
E
L
A
A
L
K
R
S
A
E
T
L
K
------