@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2664: (2016-04-06 )
MRAAVLYENNVIKAEQIDEATCGKDQVRVEVKAVGICGSDIHKMQTRWKYPLPAVMGHEFAGVITEIGSEVTNVAMGDRVAGIPLEPCMECNYCKAGDFALCDNYRMVGSHFHGGFAENVVMKADNVISIGDLDFEEGAMIEPLAVSMHGVLGIQPRLGDTVIVFGIGTIGILVVQCLLLAGVKDIIAVDISDKKLADAREFGCKYTINPKNEDLKERVFAYTNGLGADIALECAGSKITQEQCLLVTKKKGKVGFLGIAYADVLLHEEAFENIFRRELTLKGFWNSYSAPFPGEEWRTSIEFVKQGRIKLKPLISHRYKLEETKEAFDMILSREHDYNKVMILPQKGDD
Atome Classification :
(20 SA)
........-.-10--.-..-......20........30........40....----...----.----50........60........70........80...--.....90........100.......110.-.......120......-.130.-.......140........150.-..-....160.....-..170.......180.......190.......200.....--.--.210.---.----.....220.......230.......240....----...250.......260.......270.-.-......280.......290.......300.......310.......-320........330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
A
A
V
L
YE-N-N---V-I
K
-
A
E
QIDEATCGK
D
Q
V
R
V
E
V
K
A
V
GICG
S
D
I
H
K
M
Q
----TRW----K----YP
L
P
A
V
M
G
H
E
F
A
G
V
I
T
E
I
G
S
E
V
T
N
VAMGDRVAGI
P
--
L
E
P
CMECNYCKAGD
F
A
LCDN
Y
R
M
V
G
S-HF-HGGF
A
E
N
V
V
MKAD
N
V
I
-
S
I-GD-LDFEEG
A
M
-IE
P
L
A
VSMH
G
V
LG-IQ-PRLG
D
T
V
I
V
F
G
I
-
G
T
I
G
I
L
V
V
Q
C
L
L
L
AG
V
K
D
I
I
A
V
DISDK
K
L
A
D
A
R
EFG
C
K
Y
T
--I--NPKN
E
---
D
----
L
K
E
R
V
F
A
YTNGLGA
D
I
A
L
ECAGSKI
T
Q
E
Q
C
L
L
----
V
TKKKGKV
G
F
L
G
I
A
Y
A
D
V
L
L
H
E
E
A
F
-
E
-
N
-
I
F
R
R
E
L
T
L
K
GFWNSYSAPFP
G
E
E
W
R
T
S
I
E
F
V
K
QG
R
I
K
L
K
P
L
I
S
H
R
Y-
K
-
L
E
E
T
K
E
A
F
D
M
I
L
SREHDY
N
K
V
M
I
LPQKGDD
9
PsiBlast_PDB
83.46
29%
-119
- C1 -
1E3J
4
?
A:
[7-351]
--
S
A
V
L
Y
K
-
Q
-
N
---
D
-
L
R
-
L
E
Q
R
P
I
P
E
P
K
E
D
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
H
Y
Y
E
HGRI
A
D
F
----
I
----
V
K
D
P
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
--
G
V
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
C
A
T
-
P
P
D
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
-
K
L
-
P
D
N
V
S
L
E
E
G
A
L
-
L
E
P
L
S
V
G
V
H
A
C
R
R
-
A
G
-
V
Q
L
G
T
T
V
L
V
I
G
A
-
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
F
-
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
T
LV
V
--
D
P
A
K
E
---
E
E
S
S
-
I
I
E
R
I
R
S
A
I
G
D
L
-
P
N
V
T
I
D
C
S
G
N
----
E
K
C
I
T
I
G
I
N
I
T
R
T
G
G
T
L
M
L
V
G
M
G
S
Q
M
V
T
V
---
P
L
-
V
-
N
-
A
C
A
R
E
I
D
I
K
S
V
F
R
-
Y
C
N
D
Y
P
-----
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
-
K
-
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
T
I
K
V
M
I
S
C
R
Q
---
57
HHSearch
79.85
29%
-110
- C1 -
1E3J
4
?
A:
[5-351]
N
L
S
A
V
L
Y
K
-
Q
-
N
---
D
-
L
R
-
L
E
Q
R
P
I
P
E
P
K
E
D
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
H
Y
Y
E
----
H
G
R
IADF
I
----
V
K
D
P
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
--
G
V
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
C
A
T
P
P
D
-
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
-
K
L
P
D
N
-
V
S
L
E
E
G
A
L
-
L
E
P
L
S
V
G
V
H
A
C
R
R
-
A
G
-
V
Q
L
G
T
T
V
L
V
I
G
A
-
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
F
-
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
T
--
L
VV
D
P
A
K
E
E
E
S
S
----
I
I
E
R
I
R
S
A
I
-
G
D
L
P
N
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
----
I
T
R
T
G
G
T
L
M
L
V
-
G
M
G
S
Q
M
--
V
T
V
P
L
-
V
-
N
-
A
C
A
R
E
I
D
I
K
S
V
---
F
-
R
--
Y
C
N
D
Y
P
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
-
K
-
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
T
I
K
V
M
I
S
C
R
Q
---
4
PsiBlast_PDB
77.18
34%
-95
- C1 -
4UEO
3
?
A:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
23
PsiBlast_CBE
76.52
34%
-94
- C1 -
4UEJ
4
?
B:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
2
PsiBlast_PDB
75.47
34%
-94
- C1 -
4UEJ
4
?
A:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
22
PsiBlast_CBE
75.09
34%
-93
- C1 -
4UEK
4
?
B:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
3
PsiBlast_PDB
75.06
34%
-93
- C1 -
4UEK
4
?
A:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
1
PsiBlast_PDB
74.66
34%
-95
- C1 -
4A2C
3
GATD_ECOLI
A:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
24
PsiBlast_CBE
74.50
34%
-95
- C1 -
4A2C
3
GATD_ECOLI
B:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
49
HHSearch
74.20
30%
-102
* C1 *
2DQ4
3
TDH_THET8
A:
[1-342]
M
R
A
L
A
K
L
A
-
P
E
E
---
G
-
L
T
-
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
A
----
W
A
R
G
R
I
R
P
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
--
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
-
D
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
-
V
N
P
K
D
-
L
P
F
E
V
A
A
I
-
L
E
P
F
G
N
A
V
H
T
V
Y
A
-
G
S
-
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
--
V
--
N
P
L
E
E
---
D
----
L
L
E
V
V
R
R
V
T
-
G
S
G
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
----
A
L
I
P
G
G
E
A
R
I
L
-
G
I
P
S
D
P
--
I
R
F
D
L
A
G
-
E
-
L
V
M
R
G
I
T
A
F
G
I
A
G
R
--
R
--
L
W
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
-
L
S
R
Y
R
E
A
F
G
L
L
A
S
G
Q
--
A
V
K
V
I
L
D
P
K
----
11
PsiBlast_PDB
74.08
30%
-108
- C1 -
2DFV
3
TDH_PYRHO
A:
[20-333]
----------------------
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
W
A
Q
S
-
R
----
I
K
P
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
--
H
I
V
C
G
K
C
Y
A
C
R
R
G
Q
Y
H
V
C
Q
N
T
K
I
F
G
V
-
D
T
-
D
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
K
N
P
-
K
S
-
I
P
P
E
Y
A
T
L
-
Q
E
P
L
G
N
A
V
D
T
V
L
A
--
G
-
P
I
S
G
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
Y
P
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
V
--
I
--
N
P
F
E
E
---
D
----
V
V
K
E
V
M
D
I
T
D
G
N
G
V
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
----
A
V
T
P
A
G
R
V
S
L
L
G
L
Y
P
G
K
V
T
I
D
---
F
-
N
-
N
L
I
I
F
K
A
L
T
I
Y
G
I
T
G
R
H
L
W
----
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
-
K
G
F
D
K
Y
E
E
A
F
E
L
--------------------
45
HHSearch
73.90
29%
-101
- C1 -
2EIH
1
?
A:
[1-342]
M
R
A
V
V
M
R
A
-
R
-
G
GPE
V
-
L
E
-
V
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
----
G
V
A
SP--
K
----
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
F
A
P
G
D
E
V
V
I
N
P
--
G
L
S
C
G
R
C
E
R
C
L
A
G
E
D
N
L
C
P
R
Y
Q
I
L
G
E
-
H
R
-
H
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
-
P
K
P
K
N
-
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
-
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
--
V
--
N
Y
T
H
P
---
D
----
W
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
-
Y
F
E
G
V
I
K
----
A
T
A
N
G
G
R
I
A
I
A
-
G
A
S
S
G
Y
-
E
G
T
L
P
F
-
A
-
H
-
V
F
Y
R
Q
L
S
I
L
G
S
---
T
M
A
--
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
--
K
P
V
V
G
Q
V
L
-
P
-
L
E
A
A
A
E
G
H
R
L
L
E
E
R
R
V
-
F
G
K
V
V
L
Q
V
-----
21
PsiBlast_CBE
73.27
34%
-89
- C1 -
4UEO
3
?
B:
[1-346]
M
K
S
V
V
N
D
T
-
D
-
G
---
I
-
V
R
V
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
----
A
----
H
Y
Y
P
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
--
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-
R
R
-
D
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
-
A
L
P
T
D
-
M
P
I
E
D
G
A
F
-
I
E
P
I
T
V
G
L
H
A
F
H
L
-
A
Q
-
G
C
E
N
K
N
V
I
I
I
G
A
-
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
--
F
--
N
S
S
E
M
---
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
F
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
----
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
-
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
-
F
E
S
F
A
Q
A
V
R
D
I
-
A
R
N
A
M
P
G
K
V
L
L
I
P
-----
28
PsiBlast_CBE
72.08
31%
-107
- C1 -
3PII
4
ADH3_GEOSE
D:
[1-337]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
PV--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
AAKF
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
-----
44
HHSearch
71.72
29%
-108
- C1 -
2D8A
6
TDH_PYRHO
A:
[5-347]
M
V
A
I
M
K
T
K
-
P
-
G
---
Y
G
A
E
-
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
----
W
N
E
W
A
Q
S
R
----
I
K
P
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
--
H
I
V
C
G
K
C
Y
------------
T
K
I
F
G
V
-
D
T
-
D
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
-
K
N
P
K
S
-
I
P
P
E
Y
A
T
L
-
Q
E
P
L
G
N
A
V
D
T
V
L
--
A
G
-
P
I
S
G
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
Y
P
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
V
--
I
--
N
P
F
E
E
---
D
----
V
V
K
E
V
M
D
I
T
D
G
N
G
V
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
----
A
V
T
P
A
G
R
V
S
L
L
-
G
L
Y
P
G
K
--
V
T
I
D
F
-
N
N
L
-
I
I
F
K
A
L
T
I
Y
G
I
T
---
G
R
-
H
L
W
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
-
F
D
K
Y
E
E
A
F
E
L
M
R
A
G
K
--
T
G
K
V
V
F
M
L
-----
26
PsiBlast_CBE
71.60
31%
-103
- C1 -
1RJW
5
ADH3_GEOSE
C:
[1-339]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
PV--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
AAKF
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
D
K
---
29
PsiBlast_CBE
71.13
31%
-105
- C1 -
3PII
5
ADH3_GEOSE
C:
[1-337]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
PV--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
AAKF
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
-----
27
PsiBlast_CBE
70.83
31%
-102
- C1 -
1RJW
6
ADH3_GEOSE
B:
[1-339]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
PV--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
AAKF
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
D
K
---
14
PsiBlast_PDB
70.72
31%
-106
- C1 -
3PII
5
ADH3_GEOSE
A:
[1-337]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
V
--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
A
A
K
F
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
-----
13
PsiBlast_PDB
70.68
31%
-102
- C1 -
1RJW
4
ADH3_GEOSE
A:
[1-339]
M
K
A
A
V
V
E
Q
F
K
-
E
---
P
-
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
PV--
K
----
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
WL
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
-
S
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
-
K
I
-
P
D
N
L
S
F
E
E
A
A
P
-
I
F
C
A
G
V
T
T
Y
K
A
L
K
-
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
--
V
--
N
P
L
K
E
---
D
A
A
K
F
M
K
E
K
V
G
------
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
----
S
I
R
R
G
G
A
C
V
L
V
G
------
L
P
P
E
E
M
P
-
I
-
P
-
I
F
--
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
-
P
-
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
D
K
---