@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0044: (2015-11-27 )
MNLFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDCSASRVSEVIVAPYDDVEALGQLAARCDVLTYEFENVDADGLDAVVSAGQLPQGTDLLRISQNRIFEKDFLANKAGVTVAPYKVVTSSLDLEGFDLTKTYVLKTATGGYDGHGQKVIRSAEDLPEAQQLANSAECVLEEFVDFDLEISVIVSGNGQDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKMAVQIAKELQLSGTLCVEMFVTADDIIVNEIAPRPHNSGHYSIEACDFSQFDTHILGVLGQPLPPIKLHAPAVMLNVLGQHVQQAIDYVAENPSAHLHIYGKLEAKHNRKMGHVTVFTEDADEVEEF
Atome Classification :
(23 SA)
.........10........20........30........40....-..-..50........60........70........80....-....-90-.........100.......110.......120.......130--.--.-.....-----.140.......150.......160.......170--.......180......-.--190.-.-.-.....200.......210.......-220..-.....230.......240.......250.-.-.-....260.......270.......280.......290..-....-.300......-.310--------.-..------......320.......330...---....340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
L
F
K
T
I
G
IIGG
G
Q
L
G
Q
M
M
A
I
A
A
I
Y
MG
H
K
V
I
T
LDPASDC
S
A
S
R
V
S
-
E
V
-
I
VAPY
D
D
V
E
A
L
G
Q
L
A
A
RC
D
V
L
T
Y
E
FENVDAD
G
L
D
A
V
V
S-AGQL-P--QGT
D
L
L
R
ISQNRI
F
E
K
D
FLANKAG
V
T
VAP
Y
K
V
V
TSSLDLE-G--F--D-
L
T
K
T
Y
-----
V
L
K
TATGGYDG
H
G
Q
K
V
I
R
S
A
EDL
P
E
A
Q
Q
L
A
N
S
A
E
--
C
V
L
E
E
F
VDFD
L
E
I
S
V
I
-
V
--S-GN-G-
Q
-
D
V
T
V
F
PVQENIHRNNILSKTIVP
A
R
-
I
S
D
Q
L
-
A
D
K
A
K
K
M
A
V
Q
I
A
K
E
LQLS
G
T
L
C
V
E
M
F
VTA-
D
-
D
-
I
I
V
N
EIAPRPHNSG
H
Y
S
I
E
ACD
F
S
Q
F
D
T
H
I
L
G
V
LGQPLP-PIKL-H
A
P
A
V
M
L
N
V
L
-
G
Q
----------
H
-
V
Q
------
Q
A
I
D
Y
V
AENPS
A
H
L
H
I
Y
G
K
L
EA---KHNRKMG
H
V
T
V
FTE
D
A
D
E
V
EEF
1
PsiBlast_PDB
87.05
50%
-107
- C2 -
4DLK
7
?
A:
[9-360]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
4
PsiBlast_PDB
86.66
50%
-106
- C2 -
3R5H
3
?
A:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
3
PsiBlast_PDB
86.58
50%
-108
- C2 -
3QFF
1
?
A:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
23
PsiBlast_CBE
86.38
50%
-107
- C2 -
3QFF
1
?
B:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
IA
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
IR
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
2
PsiBlast_PDB
86.33
50%
-106
- C2 -
3Q2O
1
?
A:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
5
PsiBlast_PDB
86.31
50%
-104
- C2 -
3V4S
3
?
A:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
24
PsiBlast_CBE
86.15
50%
-107
- C2 -
3Q2O
1
?
B:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
IA
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
IR
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
21
PsiBlast_CBE
86.00
50%
-105
- C2 -
4DLK
4
?
B:
[9-360]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
IA
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
IR
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
25
PsiBlast_CBE
85.55
50%
-107
- C2 -
3V4S
4
?
B:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
I
A
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
I
R
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
22
PsiBlast_CBE
84.97
50%
-105
- C2 -
3R5H
3
?
B:
[15-366]
----
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
-
H
A
Y
L
-
P
--
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
-
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
--
A
IA
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
IR
S
-
V
S
-
G
---
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
-
I
E
------
G
V
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
84
HHSearch
84.93
50%
-98
* C2 *
3Q2O
1
?
A:
[13-371]
--
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
-
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
W
L
E
K
H
A
Y
L
P
----
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
-
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
-
E
A
I
A
--
E
-
L
S
Y
P
S
-----
V
L
K
T
T
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
K
E
V
S
V
I
-
V
--
I
-
R
S
V
S
-
G
-
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
E
E
L
-
S
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
-
D
G
E
-
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
-
E
T
N
L
-
L
K
P
V
V
M
V
N
I
L
G
E
H
I
---------
E
-
G
V
--------
L
R
Q
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
---
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
N
I
E
V
A
L
E
K
82
HHSearch
82.24
48%
-94
- C2 -
3ORQ
3
?
A:
[10-368]
-
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
A
-
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
K
Y
N
I
P
----
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
-
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
-
K
A
I
E
--
T
-
L
G
Y
P
F
-----
I
V
K
T
R
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
K
E
V
S
L
T
-
V
--
T
-
R
G
-
N
N
N
-
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
D
--
K
-
T
A
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
-
Q
-
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
-
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
-
G
K
----------
D
L
D
L
-------
L
E
N
E
F
N
E
H
P
E
W
H
L
H
I
Y
---
G
K
SER
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
6
PsiBlast_PDB
80.37
46%
-96
- C2 -
3ORQ
3
?
A:
[22-367]
-------------
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
A
H
E
F
-
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
L
L
C
E
-
K
Y
N
I
-
P
--
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
-
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
-
K
--
A
I
E
T
-
L
G
Y
P
F
-----
I
V
K
T
R
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
K
E
V
S
L
T
-
V
--
T
R
G
N
-
N
-
N
-
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
-
D
K
T
-
A
E
-
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
-
N
-
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
-
L
K
P
A
V
M
M
N
L
L
-
G
K
----------
D
-
L
D
------
L
L
E
N
E
F
N
E
H
P
E
W
H
L
H
I
Y
G
K
S
E
R
---
K
D
S
R
K
M
G
H
M
T
V
L
T
N
D
V
N
Q
T
E
Q
D
88
HHSearch
78.27
40%
-97
- C2 -
3AX6
1
?
A:
[1-360]
---
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
A
G
Q
V
A
-
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
K
L
-
Y
N
E
G
Y
K
I
H
--
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
-
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
S
D
V
----
R
--
E
-
F
G
F
P
V
-----
V
Q
K
A
R
K
G
-----
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
----
K
G
E
--
T
Y
L
E
E
F
V
E
I
E
K
E
L
A
V
M
-
V
--
A
-
R
N
E
K
-
G
-
E
I
A
C
Y
P
V
V
E
M
Y
------
D
T
V
I
A
P
A
R
-
I
E
E
K
Y
-
S
K
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
-
Q
G
E
-
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
-
S
T
E
L
-
L
I
P
A
V
M
V
N
L
L
-
G
E
----------
E
-
G
Y
Y
G
K
P
A
L
I
G
L
E
E
A
L
A
I
E
G
L
S
L
H
F
Y
G
K
K
E
T
---
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
D
V
E
R
A
L
E
K
8
PsiBlast_PDB
78.14
39%
-93
- C2 -
4E4T
3
?
A:
[38-402]
------
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
A
-
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
V
-
A
--
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
-
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
-
A
--
L
--
D
-
D
A
A
L
D
A
V
LP
G
I
L
K
T
A
R
L
G
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
Y
E
V
S
A
L
-
I
--
A
R
G
A
-
D
-
G
-
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
-
D
G
S
-
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
-
N
P
R
Q
-
H
S
P
A
A
M
L
N
I
L
-
G
D
VWFPNGAAA
G
A
-
V
T
------
P
P
W
D
T
V
A
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
---
R
V
G
R
K
M
G
H
V
N
F
T
A
E
M
R
D
D
A
V
A
A
26
PsiBlast_CBE
76.48
39%
-95
- C2 -
4E4T
2
?
B:
[38-402]
------
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
A
-
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
F
L
A
R
-
T
T
F
V
-
A
--
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
-
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
-
A
--
L
--
D
-
D
A
A
L
D
A
V
LP
G
I
L
K
T
A
R
-----
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
Y
E
V
S
A
L
-
I
--
A
R
G
A
-
D
-
G
-
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
-
D
G
S
-
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
-
N
P
R
Q
-
H
S
P
A
A
M
L
N
I
L
-
G
D
VWFPNGAAA
G
A
-
V
T
------
P
P
W
D
T
V
A
A
M
P
A
A
H
L
H
L
Y
G
K
E
E
A
---
R
V
G
R
K
M
G
H
V
N
F
T
A
E
M
R
D
D
A
V
A
A
15
PsiBlast_PDB
75.27
33%
-88
- C2 -
4MAM
3
?
A:
[3-350]
------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
E
E
V
V
K
-
T
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
-
Y
--
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
-
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
-
S
--
A
V
D
D
-
H
G
L
P
A
-----
I
L
K
T
R
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
-
C
--
T
-
A
D
-
L
-
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
V
V
L
-
A
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
-
D
-
E
-
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
--
S
R
K
T
V
M
L
N
C
I
-
G
G
-------------
M
------
P
A
T
K
D
L
A
A
L
D
R
V
K
I
H
S
Y
N
K
-
E
P
---
R
K
G
R
K
V
G
H
L
N
L
N
L
N
--
D
E
T
D
E
Y
13
PsiBlast_PDB
74.47
33%
-90
- C2 -
4MA0
4
?
A:
[3-350]
------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
E
E
V
V
K
-
T
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
-
Y
--
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
-
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
-
S
--
A
V
D
D
-
H
G
L
P
A
-----
I
L
K
T
R
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
-
C
--
T
-
A
D
-
L
-
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
V
V
L
-
A
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
-
D
-
E
-
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
--
S
R
K
T
V
M
L
N
C
I
-
G
G
-------------
M
------
P
A
T
K
D
L
A
A
L
D
R
V
K
I
H
S
Y
N
K
-
E
P
---
R
K
G
R
K
V
G
H
L
N
L
N
L
N
--
D
E
T
D
E
Y
16
PsiBlast_PDB
74.44
33%
-88
- C2 -
4M9U
12
?
A:
[3-350]
------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
E
E
V
V
K
-
T
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
-
Y
--
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
-
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
-
S
--
A
V
D
D
-
H
G
L
P
A
-----
I
L
K
T
R
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
-
C
--
T
-
A
D
-
L
-
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
V
V
L
-
A
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
-
D
-
E
-
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
--
S
R
K
T
V
M
L
N
C
I
-
G
G
-------------
M
------
P
A
T
K
D
L
A
A
L
D
R
V
K
I
H
S
Y
N
K
-
E
P
---
R
K
G
R
K
V
G
H
L
N
L
N
L
N
--
D
E
T
D
E
Y
14
PsiBlast_PDB
74.30
33%
-90
- C2 -
4MA5
5
?
A:
[3-350]
------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
E
E
V
V
K
-
T
V
-
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
A
I
N
H
-
E
V
S
V
-
Y
--
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
-
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
-
S
--
A
V
D
D
-
H
G
L
P
A
-----
I
L
K
T
R
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
Y
E
V
S
Q
I
-
C
--
T
-
A
D
-
L
-
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
V
V
L
-
A
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
----
E
-
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
-
D
T
T
--
S
R
K
T
V
M
L
N
C
I
-
G
G
-------------
M
------
P
A
T
K
D
L
A
A
L
D
R
V
K
I
H
S
Y
N
K
-
E
P
---
R
K
G
R
K
V
G
H
L
N
L
N
L
N
--
D
E
T
D
E
Y
83
HHSearch
73.37
36%
-89
- C2 -
3AW8
2
?
A:
[1-351]
-----
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
-
E
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
R
L
E
G
R
L
P
L
--
Y
--
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
-
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
-
E
GL
K
--
R
-
V
G
L
P
A
-----
L
L
K
T
R
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
-
A
--
V
-
R
G
R
T
-
G
-
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
E
A
L
-
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
-
E
-
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
-
S
T
A
P
-
R
G
Q
S
A
M
V
N
L
I
-
G
E
----------
K
-
P
--------
P
F
A
E
V
L
K
V
E
G
A
H
L
H
W
Y
G
K
A
-
V
---
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
27
PsiBlast_CBE
71.01
35%
-89
- C2 -
3AW8
3
?
B:
[12-351]
----------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
-
E
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
--
A
R
R
L
-
E
G
R
L
-
P
LY
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
-
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
--
L
--
K
R
V
G
L
P
A
-----
L
L
K
T
R
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
A
V
--
R
-
G
R
-
T
-
G
-
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
E
A
L
-
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
-
E
-
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
-
S
T
A
P
-
R
G
Q
S
A
M
V
N
L
I
-
G
E
-------------
K
------
P
P
F
A
E
V
L
K
V
E
G
A
H
L
H
W
Y
G
K
-
A
V
---
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G
9
PsiBlast_PDB
68.77
35%
-86
- C2 -
3AW8
2
?
A:
[12-351]
----------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
-
E
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
--
A
R
R
L
-
E
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
-
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
--
L
--
K
R
V
G
L
P
A
-----
L
L
K
T
R
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
R
E
V
S
L
L
A
V
--
R
-
G
R
-
T
-
G
-
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
E
A
L
-
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
-
E
-
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
-
S
T
A
P
-
R
G
Q
S
A
M
V
N
L
I
-
G
E
-------------
K
------
P
P
F
A
E
V
L
K
V
E
G
A
H
L
H
W
Y
G
K
-
A
V
---
R
P
G
R
K
V
G
H
I
T
L
R
R
D
G
L
K
A
L
E
E
G