@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0874: (2015-12-03 )
MKIMFVAAEGAPFAKTGGLGDVIGALPKSLSKKGHDVVVVMPYYDMVDQKFGDQIENLMYFYTDVGWRHQYVGVKRLSQDNVTFYFIDNQYYFYRGHVYGDWDDGERFAYFQLAALELMEKINFIPDVLHVHDYHTAMIPFLLKEKYHWIQAYNNIRTVFTIHNIEFQGQFGPEMLGDLFGVGAERYEDGTLRWNNCLNWMKAAILYSDRVTTVSPSYANEIKTPEFGKGLDQIMRMEAGKLSGIVNGIDSDLLNPETDAFLPYHFSKSNLEGKIKNKLALQENLGLPQDKNVPLIGIVSRLTDQKGFDIIASELDNMLQQDIQMVILGTGYHHFEETFSYFASRYPEKLSANITFDLRLAQQIYAASDIFMMPSAFEPCGLSQMMAMRYGSLPLVHEVGGLKDTVVAFNQFDGSGTGFSFNHFSGYWLMQTLKLALEVYNDYPEAWKKLQWQAMSKDFSWDTACVAYEQLYQQLQ
Atome Classification :
(20 SA)
.........10........20........30........40...--.....50------........60..-..-....70......---..80........90....-------....------100------.------...-.-...110.----.....---..120.----------.----------..---..-..130........140.......150.......160.......----------170--..----...-....180...---...---.190.........200.......210.......220........230.--..--.--...240--........250.......260....-...270..-......280.......290.......300..-.....310.......320--.........330.......340.......350....-...360....-...370.......380.......390.......400.....---..---------410--....---....----------420......----------.430.......-440.--......450...--....460.......470....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
M
F
V
AAEGAPFAKTGG
L
G
D
V
I
G
A
L
P
K
S
L
SKKGH
D
V
V
V
V
MP
Y
Y
--
D
M
V
D
Q
K
F
------
G
D
Q
I
E
N
L
M
Y
F
YT-DV-GWRHQYV
G
V
K
RL---SQD
N
V
T
F
Y
F
ID
N
Q
Y
Y
F
Y
R
-------
G
H
V
Y
------G-D------W------DDG-
E
-
R
F
A
Y
-
F
Q
----
L
A
A
L
E
---
L
M
E
K
-I----------N----------F
I
---
P
D
-
V
L
H
V-HD
Y
H
T
A
M
I
P
F
L
L
K
E
K
Y
H
W
I
Q
A
YNN
I
R
T
V
F
T
I
H
N
I
E
F
QG----------Q----F
G
----
P
E
M
-
L
G
D
L
F
GVG
A
E
---RYE---DG--TL
R
W
N
N
C
L
N
W
M
K
A
A
I
LYSDRVTTVSPSYANE-IKT
P
E
F
G
K
G
L
D
Q
--
I
M
--
R
--
M
E
A
G
K
---
L
S
G
I
V
NGI
D
S
DLLNPETDA
F
L
P
Y
HF-SKSNL-EG-
K
I
K
N
K
L
A
L
Q
E
NLGLPQDKNV
P
L
I
G
I
V
S
R
L
TD-QK
G
F
D
I
I
A
S
E
L
D
N
M
L
Q
----QDI
Q
M
V
I
LGT
G
Y
H
H
F
E
E
T
F
S
Y
F
A
S
RY
P
E
K
LSA
N
I
T
F
-
D
L
R
L
A
Q
Q
I
Y
A-ASD
I
F
MMPSAFEPC
G
L
S
Q
M
M
A
M
R
YGSL
P
L
V
H
E
VGGLK
D
T
V
V
---
A
F
---------NQ---FDGS---GTGF----------SFNHF
S
G
Y
W
----------
L
M
Q
T
L
K
L
A
L
E
V
-
Y
ND
Y
--
P
E
A
W
K
K
L
Q
W
Q
AM--SKDFSW
D
T
A
C
V
A
Y
E
Q
L
Y
Q
QLQ-
9
PsiBlast_PDB
96.09
33%
-111
- C1 -
1RZU
1
GLGA1_RHIRD
A:
[1-475]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
A
V
------
T
D
P
V
K
--
C
F
E
F
T
-
D
L
L
G
E
K
A
D
L
L
E
V
Q
------
H
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
SGGPYL-
G
Q
T
G
------
K
-
D
------
Y
------
P
D
N
W
K
-
R
F
A
A
-
L
S
----
L
A
A
A
R
---
I
G
A
G
-
V
LP--------
G
----------
W
R
---
P
D
-
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
-----
Y
A
E
T
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
----------
Q
----
F
G
----
A
N
I
-
F
S
K
L
-
A
L
P
A
H
---
A
F
G
---
M
E
--
G
I
E
Y
Y
N
D
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
-
I
L
T
A
E
F
G
M
G
L
E
G
--
V
I
--
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
-
S
A
A
N
L
-
K
N
-
R
A
L
N
K
K
A
V
A
E
H
F
R
I
-
D
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
-
Q
K
G
I
D
L
M
A
E
A
V
D
E
I
V
S
----
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
A
I
G
Y
-
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
I
---
D
A
---------
N
H
A
A
L
A
S
K
A
---
A
T
G
V
----------
Q
F
S
P
V
T
L
D
G
----------
L
K
Q
A
I
R
R
T
V
R
Y
-
Y
H
D
---
P
K
L
W
T
Q
M
Q
K
L
G
M
--
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
-
21
PsiBlast_CBE
95.80
33%
-110
- C1 -
1RZU
1
GLGA1_RHIRD
B:
[1-475]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
A
V
------
T
D
P
V
K
--
C
F
E
F
T
-
D
L
L
G
E
K
A
D
L
L
E
V
Q
------
H
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
SGGPYL-
G
Q
T
G
------
K
-
D
------
Y
------
P
D
N
W
K
-
R
F
A
A
-
L
S
----
L
A
A
A
R
---
I
G
A
G
-
V
LP--------
G
----------
W
R
---
P
D
-
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
-----
Y
A
E
T
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
----------
Q
----
F
G
----
A
N
I
-
F
S
K
L
-
A
L
P
A
H
---
A
F
G
---
M
E
--
G
I
E
Y
Y
N
D
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
-
I
L
T
A
E
F
G
M
G
L
E
G
--
V
I
--
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
-
S
A
A
N
L
-
K
N
-
R
A
L
N
K
K
A
V
A
E
H
F
R
I
-
D
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
-
Q
K
G
I
D
L
M
A
E
A
V
D
E
I
V
S
----
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
A
I
G
Y
-
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
I
---
D
A
---------
N
H
AAL
A
S
K
A
---
A
T
G
V
----------
Q
F
S
P
V
T
L
D
G
----------
L
K
Q
A
I
R
R
T
V
R
Y
-
Y
H
D
---
P
K
L
W
T
Q
M
Q
K
L
G
M
--
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
-
26
HHSearch
94.93
34%
-106
- C1 -
2QZS
3
GLGA_ECOLI
A:
[1-476]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
-
Q
V
-
V
S
R
R
D
-
T
F
-
A
---
G
H
I
T
L
L
F
G
---
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
N
L
F
------
A
-
Y
------
T
------
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
L
D
P---------
F
----------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
------
G
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
-
I
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
--
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
N
L
A
D
GV
A
------------
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
-
S
R
--
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
-
47
Fugue
94.48
34%
-105
- C1 -
1RZU
1
GLGA1_RHIRD
A:
[1-477]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
A
V
------
T
D
P
V
K
C
F
E
F
-----
T
-
D
L
L
G
E
K
A
D
L
L
E
V
---
Q
H
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
S------
G
G
P
Y
------
L
-
G
QTGKDY
P
------
D
N
W
-
K
-
R
F
A
A
-
L
S
----
L
A
A
A
R
---
I
G
A
G
-
V
LP--------
G
----------
W
R
---
P
D
-
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
Y
A
E
T
-----
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
----------
Q
----
F
G
----
A
N
I
-
F
S
K
L
-
A
L
P
A
H
---
A
F
G
---
M
E
--
G
I
E
Y
Y
N
D
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
-
I
L
T
A
E
F
G
M
G
L
E
G
--
V
I
--
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
-
S
A
A
N
L
-
K
N
-
R
A
L
N
K
K
A
V
A
E
H
F
R
I
D
D
D
-
G
S
P
L
F
C
V
I
S
R
L
T
W
-
Q
K
G
I
D
L
M
A
E
A
V
D
E
I
V
S
----
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
A
I
G
Y
-
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
I
DAN
H
A
---------
A
L
---
A
S
K
A
---
A
T
G
V
----------
Q
F
S
P
V
T
L
D
G
----------
L
K
Q
A
I
R
R
T
V
R
Y
-
Y
H
D
---
P
K
L
W
T
Q
M
Q
K
L
G
M
--
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
3
PsiBlast_PDB
94.16
33%
-103
- C1 -
2QZS
3
GLGA_ECOLI
A:
[1-477]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
-
6
PsiBlast_PDB
93.65
33%
-104
- C1 -
3GUH
7
GLGA_ECOLI
A:
[1-477]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
-
11
PsiBlast_PDB
93.58
34%
-102
- C1 -
3VUE
4
SSG1_ORYSJ
A:
[10-507]
M
N
V
V
F
V
G
A
E
M
A
P
W
S
K
T
G
G
L
G
D
V
L
G
G
L
P
P
A
M
A
A
N
G
H
R
V
M
V
I
S
P
R
Y
--
D
----
Q
Y
------
K
D
A
W
D
T
S
V
V
A
E
I
-
K
V
-
A
D
R
Y
E
R
V
R
F
F
H
C
---
Y
K
R
G
V
D
R
V
F
I
D
H
P
S
F
L
E
K
---------------------------------
K
D
N
-
Q
M
R
F
S
L
-
L
C
----
Q
A
A
L
E
---
A
P
R
I
-
L
----------
N
LNNNPYFKGT
Y
G
---
E
D
-
V
V
F
V
C
N
D
W
H
T
G
P
L
A
S
Y
L
K
N
N
Y
Q
P
N
G
I
Y
R
N
A
K
V
A
F
C
I
H
N
I
S
Y
Q
G
----------
R
----
F
A
FEDY
P
E
L
N
L
S
E
R
F
R
S
S
F
D
----
F
I
---
D
G
YD
T
P
V
E
G
R
K
I
N
W
M
K
A
G
I
L
E
A
D
R
V
L
T
V
S
P
Y
Y
A
E
E
L
I
S
G
I
A
R
G
C
E
L
D
N
--
I
M
--
R
--
L
T
G
-----
I
T
G
I
V
N
G
M
D
V
S
E
W
D
P
S
K
D
K
Y
I
T
A
K
Y
D
A
T
T
A
I
-
E
A
-
K
A
L
N
K
E
A
L
Q
A
E
A
G
L
P
V
D
R
K
I
P
L
I
A
F
I
G
R
L
E
E
-
Q
K
G
P
D
V
M
A
A
A
I
P
E
L
M
Q
----
E
D
V
Q
I
V
L
L
G
T
G
K
K
K
F
E
K
L
L
K
S
M
E
E
K
Y
P
G
K
V
R
A
V
V
K
F
-
N
A
P
L
A
H
L
I
M
A
-
G
A
D
V
L
A
V
P
S
R
F
E
P
C
G
L
I
Q
L
Q
G
M
R
Y
G
T
P
C
A
C
A
S
T
G
G
L
V
D
T
V
I
---
E
------------------
G
---
K
T
G
F
----------
H
M
G
R
L
S
V
D
C
KVVE
P
S
D
V
K
K
V
A
A
T
L
K
R
A
I
K
V
-
V
G
T
----
P
A
Y
E
E
M
V
R
N
C
M
--
N
Q
D
L
S
W
K
G
P
A
K
N
W
E
N
V
L
L
G
L
G
-
2
PsiBlast_PDB
93.46
33%
-102
- C1 -
3D1J
-
GLGA_ECOLI
A:
[1-475]
M
Q
V
L
H
V
S
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
S
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
---
31
HHSearch
93.43
36%
-100
- C1 -
3VUE
4
SSG1_ORYSJ
A:
[10-511]
M
N
V
V
F
V
G
A
E
M
A
P
W
S
K
T
G
G
L
G
D
V
L
G
G
L
P
P
A
M
A
A
N
G
H
R
V
M
V
I
S
P
R
Y
--
D
Q
Y
K
D
A
W
------
D
T
S
--
V
--
V
A
E
I
-
K
V
-
A
D
R
Y
E
R
V
R
F
F
H
C
---
Y
K
R
G
V
D
R
V
F
I
D
H
P
S
F
L
E
K
--------------------------
K
------
D
N
Q
-
M
-
R
F
S
L
-
L
C
----
Q
A
A
L
E
---
A
P
R
I
-
L
NLNNNPYFKG
T
----------
Y
G
---
E
D
V
V
F
V
C
-
N
D
W
H
T
G
P
L
A
S
Y
L
K
N
N
Y
Q
P
N
G
I
Y
R
N
A
K
V
A
F
C
I
H
N
I
S
Y
Q
G
----------
R
----
F
A
----
F
E
D
-
Y
P
E
-
L
N
L
S
E
R
FRS
S
F
D
F
I
D
G
Y
D-
T
P
V
E
G
R
K
I
N
W
M
K
A
G
I
L
E
A
D
R
V
L
T
V
S
P
Y
Y
A
E
E
-
L
I
S
G
-
I
A
R
G
C
E
L
DN
I
M
------
R
L
T
G
---
I
T
G
I
V
N
G
M
D
V
S
E
W
D
P
S
K
D
K
Y
I
T
A
K
Y
-
D
A
T
T
A
I
E
A
-
K
A
L
N
K
E
A
L
Q
A
E
A
G
L
P
V
D
R
K
I
P
L
I
A
F
I
G
R
L
E
E
-
Q
K
G
P
D
V
M
A
A
A
I
P
E
L
M
Q
----
E
D
V
Q
I
V
L
L
G
T
G
K
K
K
F
E
K
L
L
K
S
M
E
E
K
Y
P
G
K
V
R
A
V
V
K
F
-
N
A
P
L
A
H
L
I
M
A
-
G
A
D
V
L
A
V
P
S
R
F
E
P
C
G
L
I
Q
L
Q
G
M
R
Y
G
T
P
C
A
C
A
S
T
G
G
L
V
D
T
V
I
---
E
G
---------
K
------------
T
G
F
HMGRLSVDCK
V
V
E
P
S
D
V
K
K
----------
V
A
A
T
L
K
R
A
I
K
-----
V
VG
T
P
A
Y
E
E
M
V
R
N
C
M
--
N
Q
D
L
S
W
K
G
P
A
K
N
W
E
N
V
L
L
G
L
G
-
28
HHSearch
93.42
33%
-104
- C1 -
1RZU
1
GLGA1_RHIRD
A:
[1-475]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
A
V
------
T
D
P
V
K
C
-
F
E
F
T
D
-
L
L
-
G
---
E
K
A
D
L
L
E
V
---
Q
H
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
S------
G
G
P
Y
LGQTGK
D
-
Y
------
P
------
D
N
W
-
K
-
R
F
A
A
-
L
S
L
A
A
A
R
I
G
A
G
---
V
L
P
-------------
G
----------
W
R
---
P
D
-
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
Y
A
E
-----
T
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
----------
Q
----
F
G
----
A
N
I
-
F
S
K
-
L
A
L
P
A
H
---
A
F
G
---
M
E
--
G
I
E
Y
Y
N
D
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
-
I
L
T
A
E
F
G
M
G
L
E
G
--
V
-------
I
G
S
R
AHV
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
-
S
A
A
N
L
-
K
N
-
R
A
L
N
K
K
A
V
A
E
H
F
R
I
D
D
-
D
G
S
P
L
F
C
V
I
S
R
L
T
W
-
Q
K
G
I
D
L
M
A
E
A
V
D
E
I
V
S
----
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
A
I
G
Y
-
N
-
E
P
L
S
H
L
M
Q
A
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
I
---
D
A
N
H
A
A
L
A
S
KA
A
------------
T
G
V
----------
Q
F
S
P
V
T
L
D
G
----------
L
K
Q
A
I
R
R
T
V
R
Y
-
Y
-
H
D
--
P
K
L
W
T
Q
M
Q
K
L
G
M
--
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
-
4
PsiBlast_PDB
92.99
33%
-103
- C1 -
2R4T
15
GLGA_ECOLI
A:
[1-477]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
-
7
PsiBlast_PDB
92.71
33%
-101
- C1 -
3COP
3
GLGA_ECOLI
A:
[1-476]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
A
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
--
12
PsiBlast_PDB
92.68
34%
-100
- C1 -
3VUF
4
SSG1_ORYSJ
A:
[10-507]
M
N
V
V
F
V
G
A
E
M
A
P
W
S
K
T
G
G
L
G
D
V
L
G
G
L
P
P
A
M
A
A
N
G
H
R
V
M
V
I
S
P
R
Y
--
D
----
Q
Y
------
K
D
A
W
D
T
S
V
V
A
E
I
-
K
V
-
A
D
R
Y
E
R
V
R
F
F
H
C
---
Y
K
R
G
V
D
R
V
F
I
D
H
P
S
F
L
E
K
---------------------------------
K
D
N
-
Q
M
R
F
S
L
-
L
C
----
Q
A
A
L
E
---
A
P
R
I
-
L
----------
N
LNNNPYFKGT
Y
G
---
E
D
-
V
V
F
V
C
N
D
W
H
T
G
P
L
A
S
Y
L
K
N
N
Y
Q
P
N
G
I
Y
R
N
A
K
V
A
F
C
I
H
N
I
S
Y
Q
G
----------
R
----
F
A
FEDY
P
E
L
N
L
S
E
R
F
R
S
S
F
D
----
F
I
---
D
G
YD
T
P
V
E
G
R
K
I
N
W
M
K
A
G
I
L
E
A
D
R
V
L
T
V
S
P
Y
Y
A
E
E
L
I
S
G
I
A
R
G
C
E
L
D
N
--
I
M
--
R
--
L
T
G
-----
I
T
G
I
V
N
G
M
D
V
S
E
W
D
P
S
K
D
K
Y
I
T
A
K
Y
D
A
T
T
A
I
-
E
A
-
K
A
L
N
K
E
A
L
Q
A
E
A
G
L
P
V
D
R
K
I
P
L
I
A
F
I
G
R
L
E
E
-
Q
K
G
P
D
V
M
A
A
A
I
P
E
L
M
Q
----
E
D
V
Q
I
V
L
L
G
T
G
K
K
K
F
E
K
L
L
K
S
M
E
E
K
Y
P
G
K
V
R
A
V
V
K
F
-
N
A
P
L
A
H
L
I
M
A
-
G
A
D
V
L
A
V
P
S
R
F
E
P
C
G
L
I
Q
L
Q
G
M
R
Y
G
T
P
C
A
C
A
S
T
G
G
L
V
D
T
V
I
---
E
------------------
G
---
K
T
G
F
----------
H
M
G
R
L
S
V
D
C
KVVE
P
S
D
V
K
K
V
A
A
T
L
K
R
A
I
K
V
-
V
G
T
----
P
A
Y
E
E
M
V
R
N
C
M
--
N
Q
D
L
S
W
K
G
P
A
K
N
W
E
N
V
L
L
G
L
G
-
5
PsiBlast_PDB
92.46
33%
-102
- C1 -
2R4U
6
GLGA_ECOLI
A:
[1-477]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
-
8
PsiBlast_PDB
92.18
33%
-104
- C1 -
3CX4
19
GLGA_ECOLI
A:
[1-476]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
G
V
------
T
D
A
--------
Q
-
V
V
-
S
R
R
D
T
F
A
G
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
S
P
Y
------
H
-
D
------
T
NLFAYT
D
N
V
-
L
-
R
F
A
L
-
L
G
----
W
V
G
A
E
---
M
A
S
G
-
L
----------
D
PF--------
W
R
---
P
D
-
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
------
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
----------
M
----
F
Y
----
A
H
H
-
M
N
D
I
-
Q
L
P
W
S
---
F
F
N
---
I
H
--
G
L
E
F
N
G
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
-
I
T
E
P
Q
F
A
Y
G
M
E
G
--
L
L
Q
Q
R
--
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
-
T
R
D
T
L
-
E
D
-
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
----
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
Q
I
G
Y
-
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
A
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
---
D
C
S
L
E
------
N
L
---
A
D
G
V
---
A
S
G
F
----------
V
F
E
D
S
N
A
W
S
----------
L
L
R
A
I
R
R
A
F
V
L
-
W
S
R
---
P
S
L
W
R
F
V
Q
R
Q
A
M
--
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
--
1
PsiBlast_PDB
89.59
36%
-98
- C1 -
4HLN
1
?
A:
[126-623]
-
S
I
V
F
V
T
G
E
A
A
P
--------
D
V
C
G
S
L
P
I
A
L
A
A
R
G
H
R
V
M
V
V
M
P
R
Y
LN
G
T
S
D
K
N
Y
AKALYT
G
K
H
I
K
I
P
C
F
G
G
S
H
E
V
-
T
F
F
H
E
Y
----------
R
D
N
V
D
W
V
F
V
D
H
P
S
Y
H
R
P
--------------------NFGAF-
G
------
D
N
Q
-
F
-
R
Y
T
L
-
L
C
----
Y
A
A
C
E
A
PL
I
L
E
L
-
G
----------
G
----------
Y
I
YGQ
S
C
-
M
F
V
V
-
N
D
W
H
A
S
L
V
P
V
L
L
A
A
K
Y
R
P
Y
G
V
Y
R
D
S
R
S
T
L
V
I
H
N
L
A
H
Q
G
VEPASTYPDL
G
----
L
P
----
P
E
W
-
Y
G
A
L
E
W
V
F
P
E
---
W
A
R
---
R
H
--
A
L
D
K
G
E
A
V
N
F
L
K
G
A
V
V
T
A
D
R
I
V
T
V
S
Q
G
Y
S
W
E
-
V
T
T
A
E
G
G
Q
G
L
N
E
--
L
L
--
S
--
S
R
K
S
V
---
L
N
G
I
V
N
G
I
D
I
N
D
W
N
P
T
T
D
K
C
L
P
H
H
Y
-
S
V
D
D
L
-
S
G
-
K
A
K
C
K
A
E
L
Q
R
E
L
G
L
P
V
R
E
D
V
P
L
I
G
F
I
G
R
L
D
Y
-
Q
K
G
I
D
L
I
K
M
A
I
P
D
L
M
R
----
E
D
V
Q
F
V
M
L
G
S
G
D
P
V
F
E
G
W
M
R
S
T
E
S
S
Y
K
D
K
F
R
G
W
V
G
F
-
S
V
P
V
S
H
R
I
T
A
-
G
C
D
I
L
L
M
P
S
R
F
E
P
C
G
L
N
Q
L
Y
A
M
Q
Y
G
T
V
P
V
V
H
G
T
G
G
L
R
D
T
V
E
---
T
F
---------
N
P
---
F
G
A
K
G
E
E
G
T
G
W
----------
A
F
S
P
L
T
V
E
K
----------
M
L
W
A
L
R
T
A
I
S
T
-
F
R
E
H
--
K
P
S
W
E
G
L
M
K
R
G
M
--
T
K
D
H
T
W
D
H
A
A
E
Q
Y
E
Q
I
F
E
W
A
F
-
13
PsiBlast_PDB
77.88
25%
-99
- C1 -
3FRO
3
?
A:
[3-427]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
R
F
Q
---------
G
E
E
I
G
K
I
R
V
F
G
E
-
E
V
-
Q
V
K
V
S
Y
E
E
R
G
N
L
---
R
I
Y
R
I
G
G
G
L
L
D
S
E
-------------
D
V
Y
------
G
P
G
------
W
------
D
G
L
-
I
-
R
K
A
V
T
F
G
----
R
A
S
V
L
---
L
L
N
D
-
L
L
R
E-------
E
----------
P
L
---
P
D
-
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
K
S
K
----------
L
P
A
F
Y
F
H
----
E
A
G
-
L
S
E
L
-----
A
---
P
Y
P
---
D
----------
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
S
R
G
Y
L
I
D
-----
E
W
G
-------
F
F
--
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
-------------
E
S
Y
L
-
T
G
S
R
D
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
-
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
KKEF
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
T
E
M
L
-
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
----------------------
N
---
E
T
G
I
----------
L
V
K
A
G
D
P
G
E
----------
L
A
N
A
I
L
K
A
L
E
L
S
R
S
D
L
--
S
K
F
R
E
N
C
K
K
R
A
M
--
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
T
G
S
I
-
14
PsiBlast_PDB
77.45
25%
-98
- C1 -
2BIS
8
?
A:
[4-428]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
R
F
Q
---------
G
E
E
I
G
K
I
R
V
F
G
E
-
E
V
-
Q
V
K
V
S
Y
E
E
R
G
N
L
---
R
I
Y
R
I
G
G
G
L
L
D
S
E
-------------
D
V
Y
------
G
P
G
------
W
------
D
G
L
-
I
-
R
K
A
V
T
F
G
----
R
A
S
V
L
---
L
L
N
D
-
L
L
R
E-------
E
----------
P
L
---
P
D
-
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
K
S
K
----------
L
P
A
F
Y
F
H
----
E
A
G
-
L
S
E
L
-----
A
---
P
Y
P
---
D
----------
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
S
R
G
Y
L
I
D
-----
E
W
G
-------
F
F
--
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
-------------
E
S
Y
L
-
T
G
S
R
D
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
-
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
KKEF
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
T
E
M
L
-
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
----------------------
N
---
E
T
G
I
----------
L
V
K
A
G
D
P
G
E
----------
L
A
N
A
I
L
K
A
L
E
L
S
R
S
D
L
--
S
K
F
R
E
N
C
K
K
R
A
M
--
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
T
G
S
I
-
15
PsiBlast_PDB
76.84
25%
-101
- C1 -
3L01
9
?
A:
[3-427]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
R
F
Q
---------
G
E
E
I
G
K
I
R
V
F
G
E
-
E
V
-
Q
V
K
V
S
Y
E
E
R
G
N
L
---
R
I
Y
R
I
G
G
G
L
L
D
S
E
-------------
D
V
Y
------
G
P
G
------
W
------
D
G
L
-
I
-
R
K
A
V
T
F
G
----
R
A
S
V
L
---
L
L
N
D
-
L
L
R
E-------
E
----------
P
L
---
P
D
-
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
K
S
K
----------
L
P
A
F
Y
F
H
----
E
A
G
-
L
S
E
L
-----
A
---
P
Y
P
---
D
----------
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
S
R
G
Y
L
I
D
-----
E
W
G
-------
F
F
--
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
-------------
E
S
Y
L
-
T
G
S
R
D
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
-
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
KKEF
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
T
E
M
L
-
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
----------------------
N
---
E
T
G
I
----------
L
V
K
A
G
D
P
G
E
----------
L
A
N
A
I
L
K
A
L
E
L
S
R
S
D
L
--
S
K
F
R
E
N
C
K
K
R
A
M
--
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
A
----
33
HHSearch
75.12
25%
-98
* C1 *
3FRO
3
?
A:
[3-430]
M
K
V
L
L
L
G
F
E
F
L
P
V
-
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
R
F
Q
G
E
E
------
I
G
K
------
I
R
V
-
F
G
-
E
--
E
V
Q
V
K
V
S
Y
E
---
E
R
G
N
L
R
I
Y
R
I
G
G
G
L
-
L
D
S
-------
E
D
V
Y
------
G
P
G
------
W
------
D
G
L
I
R
-
K
A
V
T
-
F
G
R
A
S
V
L
L
L
N
D
---
L
L
R
E
------------
E
----------
P
L
---
P
D
-
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
K
S
K
----------
L
-----
P
----
A
F
Y
-
F
H
E
----
A
G
-----
L
S
-------
E
L
A
P
Y
P
D
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
S
R
G
Y
L
I
D
-
E
W
G
F
-
F
R
--
N
------------
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
E
S
Y
L
T
G
S
--------------
R
D
E
R
K
K
S
L
L
S
K
F
G
M
---
D
E
G
V
T
F
M
F
I
G
R
F
D
R
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
KKEF
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
-
H
G
N
V
K
V
I
T
E
M
L
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
---
N
----------
E
------------
T
G
I
----------
L
V
K
A
G
D
P
G
E
----------
L
A
N
A
I
L
K
A
L
E
----
L
S
--
R
S
D
L
S
K
F
R
E
N
C
K
K
R
A
M
S
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
T
G
S
I
-