@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17680: (2016-06-28 )
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
Atome Classification :
(58 SA)
.........10........20..--------......30........40....-....50-.-..--.-.....60........70........80........90......------------...------------100------------------------------------------------.........110--.....------...---------------------------------120--.........130.......140.......150.......160.......170-----........180.......190.......200.......210.......220.......230.......240.......250----------....---....260.......270.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
NNGISDE--------E
F
D
V
R
T
KWDSDGTP
A
H
T
L
S
V
I
S
-
K
Q
MRF--D-NS--E-V
P
I
L
TTK
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
LKSNDVND
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
KQ------------E--------------------------------------------------DGTIG
H
A
Y
GFQ---LGKKN------RSL---------------------------------N----G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
KNNPSSR
R
H
I
T
M
L
WNPDEL
D
A
MALT
P
C
V
Y
E
T
Q
W
Y
V
K
H------
G
K
L
H
L
E
V
R
ARSNDMALGNP
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
VTG
Y
E
L
G
E
Y
I
F
NIGD
C
H
V
Y
T
R
HID
N
L
K
I
Q
M
E
R
E
QFEAP
E
L
W
INPEV-----------
K
D
F
Y
---DFTID
D
F
K
L
I
N
YKHG
D
K
L
L
F
E
VAV
2
PsiBlast_PDB
99.04
100%
-90
- C8 -
1BKO
-
TYSY1_BACSU
A:
[2-279]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
3
PsiBlast_PDB
98.94
100%
-93
- C- -
1BKP
-
TYSY1_BACSU
A:
[2-279]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
21
PsiBlast_CBE
98.43
100%
-90
- C8 -
1BSP
2
TYSY1_BACSU
B:
[1-278]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
1
PsiBlast_PDB
97.41
100%
-87
- C8 -
1B02
2
TYSY1_BACSU
A:
[1-279]
M
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
5
PsiBlast_PDB
96.72
100%
-90
- C8 -
1BSP
2
TYSY1_BACSU
A:
[1-278]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
---------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
4
PsiBlast_PDB
96.03
100%
-89
- C8 -
1BSF
-
TYSY1_BACSU
A:
[2-279]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
101
HHSearch
77.85
97%
11
- C- -
1BKP
-
TYSY1_BACSU
A:
[2-279]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
EFDVRTKW
D
S
D
G
T
-
P
A
-----
H
--
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
--
E
-
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
G
-
V
H
I
W
D
Q
------------
W
K
Q
------------
E
--------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
N
------
R
S
L
---------------------------------
N
----
G
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
D
F
Y
---
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
122
Fugue
75.84
100%
-1
- C- -
1BKP
-
TYSY1_BACSU
A:
[2-279]
-
T
Q
F
D
K
Q
Y
N
S
I
I
K
D
I
I
N
N
G
I
S
D
E
--------
E
F
D
V
R
T
K
W
D
S
D
G
T
P
A
H
T
L
S
V
I
S
-
K
Q
M
R
F
--
D
-
N
S
---E
V
P
I
L
T
T
K
K
V
A
W
K
T
A
I
K
E
L
L
W
I
W
Q
L
K
S
N
D
V
N
D
L
N
M
M
-G
V
H
I
W
D
Q
WKQE--------------------------------------------------------------------------
D
G
T
I
G
H
A
Y
G
F
Q
---
L
G
K
K
-NRSLNG------------------------------------------
E
K
V
D
Q
V
D
Y
L
L
H
Q
L
K
N
N
P
S
S
R
R
H
I
T
M
L
W
N
P
D
E
L
D
A
M
A
L
T
P
C
V
Y
E
T
Q
W
Y
V
K
H
------
G
K
L
H
L
E
V
R
A
R
S
N
D
M
A
L
G
N
P
F
N
V
F
Q
Y
N
V
L
Q
R
M
I
A
Q
V
T
G
Y
E
L
G
E
Y
I
F
N
I
G
D
C
H
V
Y
T
R
H
I
D
N
L
K
I
Q
M
E
R
E
Q
F
E
A
P
E
L
W
I
N
P
E
V
-----------
K
---DFY
D
F
T
I
D
D
F
K
L
I
N
Y
K
H
G
D
K
L
L
F
E
V
A
V
6
PsiBlast_PDB
66.63
38%
-48
- C8 -
3IX6
-
TYSY_BRUME
A:
[2-251]
-----
R
T
Y
L
D
L
L
Q
H
V
L
D
H
G
V
D
R
D
------------------
D
----
G
T
R
S
V
F
G
-
Y
Q
M
R
F
--
D
-
L
E
--
E
G
F
P
V
L
---
K
L
H
L
R
S
I
I
H
E
L
L
W
F
L
K
G
D
T
N
-
I
A
Y
L
K
E
N
G
-
V
T
I
W
D
E
------------
W
A
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
Y
Q
---
W
-
R
S
W
------
P
A
P
---------------------------------
D
----
G
R
H
I
D
Q
I
A
N
L
L
K
M
L
H
T
N
P
Q
S
R
R
L
I
V
S
A
W
N
P
A
L
V
D
E
M
A
L
P
P
C
H
C
L
F
Q
F
Y
V
A
N
------
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
M
M
I
A
Q
V
T
G
L
K
P
G
E
F
I
H
T
L
G
D
A
H
I
Y
S
N
H
F
E
Q
A
R
L
Q
L
T
R
T
P
K
K
L
P
V
M
H
I
N
P
D
V
-----------
K
D
L
F
---
A
F
R
F
E
D
F
R
L
D
G
-------------
51
PsiBlast_CBE
66.32
36%
3
- C8 -
3OB7
2
TYSY_HUMAN
A:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
RH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
88
PsiBlast_CBE
66.18
36%
3
- C8 -
4H1I
2
TYSY_HUMAN
A:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRD
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
50
PsiBlast_CBE
66.17
36%
5
- C8 -
3OB7
2
TYSY_HUMAN
B:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
87
PsiBlast_CBE
66.02
36%
6
- C8 -
4H1I
2
TYSY_HUMAN
B:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
54
PsiBlast_CBE
65.98
36%
5
- C8 -
3HB8
1
TYSY_HUMAN
C:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
55
PsiBlast_CBE
65.93
36%
4
- C8 -
3HB8
3
TYSY_HUMAN
B:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
56
PsiBlast_CBE
65.88
36%
2
- C8 -
3HB8
3
TYSY_HUMAN
A:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
59
PsiBlast_CBE
65.77
36%
4
- C8 -
3H9K
1
TYSY_HUMAN
C:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
83
PsiBlast_CBE
65.75
36%
2
- C8 -
5HS3
2
?
B:
[8-289]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
65
PsiBlast_CBE
65.60
36%
5
- C8 -
2RDA
2
TYSY_HUMAN
C:
[32-306]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
79
PsiBlast_CBE
65.56
36%
3
- C8 -
5HS3
1
?
F:
[8-281]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
--------
69
PsiBlast_CBE
65.45
36%
2
- C8 -
1I00
3
TYSY_HUMAN
A:
[9-283]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
42
PsiBlast_CBE
65.36
36%
2
- C8 -
1JU6
3
TYSY_HUMAN
C:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
41
PsiBlast_CBE
65.18
36%
4
- C8 -
1JU6
3
TYSY_HUMAN
D:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
20
PsiBlast_PDB
65.08
36%
3
- C8 -
2RD8
3
TYSY_HUMAN
A:
[32-308]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
RH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
-----
35
PsiBlast_CBE
64.97
36%
1
- C8 -
3EJL
2
TYSY_HUMAN
D:
[32-308]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
-----
43
PsiBlast_CBE
64.96
36%
3
- C8 -
1JU6
4
TYSY_HUMAN
B:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
12
PsiBlast_PDB
64.60
36%
4
- C8 -
1JU6
4
TYSY_HUMAN
A:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
38
PsiBlast_CBE
64.27
36%
7
- C8 -
1JUJ
3
TYSY_HUMAN
D:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
39
PsiBlast_CBE
64.12
36%
7
- C8 -
1JUJ
3
TYSY_HUMAN
C:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
40
PsiBlast_CBE
64.11
36%
7
- C8 -
1JUJ
3
TYSY_HUMAN
B:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
68
PsiBlast_CBE
64.01
36%
9
- C8 -
1I00
3
TYSY_HUMAN
B:
[9-283]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
9
PsiBlast_PDB
63.97
35%
3
- C8 -
4EB4
10
TYSY_MOUSE
A:
[26-307]
------
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
13
PsiBlast_PDB
63.87
36%
7
- C8 -
1JUJ
3
TYSY_HUMAN
A:
[32-313]
------
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
95
PsiBlast_CBE
63.73
36%
15
- C8 -
5BY6
4
?
C:
[19-303]
V
N
Q
E
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
------------------
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
CL
R
-
D
D
--
I
-
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
-
G
S
T
N
A
K
Q
L
S
E
K
N
-
V
N
I
W
D
G
NSSREFLDSRGL
Y
N
Y
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
C
P
Y
------
S
S
M
---------------------------------
T
ADYK
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
A
D
------
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
---
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
K
I
S
M
----
108
HHSearch
63.50
36%
2
- C8 -
1F28
3
TYSY_PNECA
A:
[3-297]
-
N
A
E
E
Q
Q
Y
L
N
L
V
Q
Y
I
I
N
H
G
E
D
R
P
----------
D
R
T
-
G
T
-----
G
--
T
L
S
V
F
A
P
S
P
L
K
F
--
S
-
L
R
NK
T
-
F
P
L
L
T
T
K
R
V
F
I
R
G
V
I
E
E
L
L
W
F
I
R
G
E
T
-
D
S
L
K
L
R
E
K
N
-
I
H
I
W
D
A
------------
N
G
S
R
E
Y
L
D
S
I
GLTKR
Q
--------------------------------------------------
E
G
D
L
G
P
I
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
IDCKTNY--------------------------
I
----
G
Q
G
V
D
Q
L
A
N
I
I
Q
K
I
R
T
S
P
Y
D
R
R
L
I
L
S
A
W
N
P
A
D
L
E
K
M
A
L
P
P
C
H
M
F
C
Q
F
Y
V
H
I
P
SNNH
R
P
E
L
S
C
Q
L
Y
Q
R
S
C
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
C
M
I
A
H
V
C
D
L
D
P
G
D
F
I
H
V
M
G
D
C
H
I
Y
K
D
H
I
E
A
L
Q
Q
Q
L
T
R
S
P
R
P
F
P
T
L
S
L
N
R
S
I
-----------
T
D
I
E
---
D
F
T
L
D
D
F
N
I
Q
N
Y
H
P
Y
E
T
I
K
M
K
M
S
I
115
HHSearch
63.39
31%
-7
- C8 -
3V8H
5
?
A:
[5-318]
----
M
K
Q
Y
L
D
L
V
R
T
I
L
D
T
G
T
W
Q
S
----------
N
---
G
I
-----
R
--
T
I
G
I
P
G
-
A
M
L
R
F
--
D
-
L
Q
Q-
G
-
F
P
A
V
T
T
K
K
L
A
F
K
S
A
I
G
E
L
V
G
F
L
R
A
T
R
-
S
A
A
E
F
R
A
L
G
-
C
K
V
W
D
A
------------
N
A
N
------------
E
N
A
Q
W
L
A
NPYRRG--------------------------------------
A
D
D
L
G
D
V
Y
G
V
Q
---
W
R
R
W
P
------
G
Y
K
V
L
DAHA
D
A
Q
I
A
D
A
T
S
R
G
F
R
I
V
A
R
F
E
E
GG
A
D
K
V
L
L
----
H
K
A
I
D
Q
L
R
D
C
L
D
T
I
V
R
D
P
S
S
R
R
I
L
F
H
G
W
N
P
A
V
L
D
E
I
A
L
P
A
C
H
L
L
Y
Q
F
L
P
N
V
ER----
R
E
I
S
L
C
L
Y
I
R
S
N
D
V
G
L
G
T
P
F
N
L
A
E
G
A
A
L
L
T
L
V
G
R
L
T
G
Y
S
P
R
W
F
T
Y
F
I
G
D
A
H
I
Y
E
N
Q
L
D
M
L
K
Q
Q
L
E
R
E
P
F
E
S
P
R
L
E
L
A
E
R
V
PDYAKTGKYEP
Q
W
L
E
---
R
V
E
P
S
D
F
T
L
V
G
Y
R
H
H
---------
77
PsiBlast_CBE
63.37
35%
7
- C8 -
1RTS
3
TYSY_RAT
B:
[26-303]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGSRDFLDSLGF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
----
121
HHSearch
63.24
36%
-20
- C8 -
3NRR
9
?
A:
[229-515]
-
N
H
E
E
F
Q
Y
L
D
I
L
A
D
V
L
S
H
G
V
L
K
P
----------
N
R
T
-
G
T
-----
D
--
A
Y
S
K
F
G
-
Y
Q
M
R
F
--
D
-
L
S
R-
S
-
F
P
L
L
T
T
K
K
V
A
L
R
S
I
I
E
E
L
L
W
F
I
K
G
S
T
-
N
G
N
D
L
L
A
K
N
-
V
R
I
W
E
L
------------
N
G
R
R
D
F
L
D
K
N
GFTDR
E
--------------------------------------------------
E
H
D
L
G
P
I
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
LDMHADY--------------------------
T
----
G
K
G
I
D
Q
L
A
E
I
I
N
R
I
K
T
N
P
N
D
R
R
L
I
V
C
S
W
N
V
S
D
L
K
K
M
A
L
P
P
C
H
C
F
F
Q
F
Y
V
S
D
------
N
K
L
S
C
M
M
H
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
L
T
A
M
V
A
Q
V
C
G
L
G
L
G
E
F
V
H
N
L
A
D
A
H
I
Y
V
D
H
V
D
A
V
T
T
Q
I
A
R
I
P
H
P
F
P
R
L
R
L
N
P
D
I
-----------
R
N
I
E
---
D
F
T
I
D
D
I
V
V
E
D
Y
V
S
H
P
P
I
P
M
A
M
S
A
22
PsiBlast_CBE
63.18
35%
7
- C8 -
4EIN
3
TYSY_MOUSE
B:
[26-306]
------
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGSRDFLDSLGF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
-
10
PsiBlast_PDB
63.08
35%
5
- C8 -
4EZ8
4
TYSY_MOUSE
A:
[26-307]
------
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
75
PsiBlast_CBE
63.02
35%
8
- C8 -
2TSR
3
TYSY_RAT
B:
[26-301]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGSRDFLDSLGF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
74
PsiBlast_CBE
62.88
35%
8
- C8 -
2TSR
3
TYSY_RAT
C:
[26-301]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGSRDFLDSLGF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
96
PsiBlast_CBE
62.66
36%
22
- C8 -
5BY6
4
?
B:
[19-304]
V
N
Q
E
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
------------------
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
CL
R
-
D
D
--
I
-
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
-
G
S
T
N
A
K
Q
L
S
E
K
N
-
V
N
I
W
D
G
NSSREFLDSRGL
Y
N
Y
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
C
P
Y
------
S
S
M
---------------------------------
T
ADYK
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
A
D
------
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
---
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
K
I
S
M
P
---
76
PsiBlast_CBE
62.54
35%
9
- C8 -
2TSR
3
TYSY_RAT
A:
[26-301]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
110
HHSearch
62.50
39%
-11
- C8 -
1J3K
2
?
C:
[42-328]
-
Y
H
P
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
----------
D
R
T
-
G
V
-----
G
--
V
L
S
K
F
G
-
Y
I
M
K
F
--
D
-
L
S
Q-
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
-
N
G
N
T
L
L
N
K
N
-
V
R
I
W
E
A
------------
N
G
T
R
E
F
L
D
N
R
KLFHR
E
--------------------------------------------------
V
N
D
L
G
P
I
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
TNMYDNY--------------------------
E
----
N
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
Y
V
F
D
------
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
-----------
K
N
I
E
---
D
F
T
I
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
78
PsiBlast_CBE
62.42
35%
6
- C8 -
1RTS
3
TYSY_RAT
A:
[26-300]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
93
PsiBlast_CBE
62.36
38%
7
- C8 -
1HVY
4
TYSY_HUMAN
A:
[24-288]
-----------------------------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGS
R
D
F
L
D
S
L
GF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
97
PsiBlast_CBE
62.33
36%
22
- C8 -
5BY6
7
?
A:
[19-300]
V
N
Q
E
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
------------------
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
C
L
R
-
D
D
--
I
-
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
-
G
S
T
N
A
K
Q
L
S
E
K
N
-
V
N
I
W
D
G
NSS
R
E
F
L
D
S
R
GL
Y
N
Y
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
C
P
Y
------
S
S
M
---------------------------------
T
ADYK
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
A
D
------
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
---
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
K
-------
112
HHSearch
62.13
35%
-27
- C8 -
4FQS
3
TYSY_MYCTU
A:
[1-263]
----
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
----------
D
R
T
-
G
T
-----
G
--
T
R
S
L
F
G
-
Q
Q
M
R
Y
--
D
-
L
S
A-
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
-
N
I
G
W
L
H
E
H
G
-
V
T
I
W
D
E
------------
W
A
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
---
W
R
S
W
P
------
A
P
S
--------------------------------------
G
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
Y
V
A
D
------
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
-
R
-----------
D
S
I
F
---
E
Y
T
Y
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
91
PsiBlast_CBE
62.12
38%
9
- C8 -
1HVY
4
TYSY_HUMAN
C:
[24-288]
-----------------------------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
94
PsiBlast_CBE
62.06
36%
19
- C8 -
5BY6
8
?
D:
[19-299]
V
N
Q
E
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
------------------
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
CL
R
-
D
D
--
I
-
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
-
G
S
T
N
A
K
Q
L
S
E
K
N
-
V
N
I
W
D
G
NSSREFLDSRGL
Y
N
Y
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
C
P
Y
------
S
S
M
---------------------------------
T
ADYK
G
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
Y
V
A
D
------
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
-----------
E
N
I
D
---
D
F
R
A
E
D
F
E
L
I
N
Y
K
P
Y
P
--------
116
HHSearch
61.87
38%
-12
* C8 *
4XSC
3
TYSY_VZVO
A:
[31-309]
-
L
T
G
E
L
Q
Y
L
K
Q
V
D
D
I
L
R
Y
G
V
R
K
R
----------
D
R
T
-
G
I
-----
G
--
T
L
S
L
F
G
-
M
Q
A
R
Y
--
N
-
L
R
N-
E
-
F
P
L
L
T
T
K
R
V
F
W
R
A
V
V
E
E
L
L
W
F
I
R
G
S
T
-
D
S
K
E
L
A
A
K
D
-
I
H
I
W
D
-------------------------------------------------------------------------------
T
G
D
L
G
P
I
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
KDCQSNY--------------------------
L
----
Q
Q
G
I
D
Q
L
Q
T
V
I
D
T
I
K
T
N
P
E
S
R
R
M
I
I
S
S
W
N
P
K
D
I
P
L
M
V
L
P
P
C
H
T
L
C
Q
F
Y
V
A
N
------
G
E
L
S
C
Q
V
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
G
Y
A
L
L
T
Y
I
V
A
H
V
T
G
L
K
T
G
D
L
I
H
T
M
G
D
A
H
I
Y
L
N
H
I
D
A
L
K
V
Q
L
A
R
S
P
K
P
F
P
C
L
K
I
I
R
N
V
-----------
T
D
I
N
---
D
F
K
W
D
D
F
Q
L
D
G
Y
N
P
H
P
--------
119
HHSearch
61.77
39%
-10
- C8 -
3QG2
2
?
A:
[322-608]
-
Y
H
P
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
----------
D
R
T
-
G
V
-----
G
--
V
L
S
K
F
G
-
Y
I
M
K
F
--
D
-
L
S
Q-
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
-
N
G
N
T
L
L
N
K
N
-
V
R
I
W
E
A
------------
N
G
T
R
E
F
L
D
N
R
KLFHR
E
--------------------------------------------------
V
N
D
L
G
P
I
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
TNMYDNY--------------------------
E
----
N
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
Y
V
F
D
------
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
-----------
K
N
I
E
---
D
F
T
I
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
73
PsiBlast_CBE
61.73
35%
6
- C8 -
2TSR
3
TYSY_RAT
D:
[26-301]
------
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
NGSRDFLDSLGF
S
A
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
D
Y
------
K
D
M
DSDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
92
PsiBlast_CBE
61.54
38%
6
- C8 -
1HVY
4
TYSY_HUMAN
B:
[24-288]
-----------------------------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
103
HHSearch
61.35
38%
2
- C8 -
4EZ8
4
TYSY_MOUSE
A:
[21-307]
-
R
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
----------
D
R
T
-
G
T
-----
G
--
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
-
L
R
D-
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
-
N
A
K
E
L
S
S
K
G
-
V
R
I
W
D
A
------------
N
G
S
R
D
F
L
D
S
L
GFSAR
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
---
W
R
H
F
G
------
A
E
Y
KDMDSDY--------------------------
S
----
G
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
-----------
E
T
I
D
---
D
F
K
V
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
90
PsiBlast_CBE
60.52
38%
11
- C8 -
1HVY
4
TYSY_HUMAN
D:
[24-288]
-----------------------------------------
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
--
S
L
R
D
--
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
-
G
S
T
N
A
K
E
L
S
S
K
G
-
V
K
I
W
D
A
NGSRDFLDSLGF
S
T
R
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
WRH
F
G
A
E
Y
------
R
D
M
ESDY-----------------------------
S
----
G
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
Y
V
V
N
------
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-----------
E
K
I
D
---
D
F
K
A
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
104
HHSearch
58.18
38%
9
- C8 -
4DQ1
2
TYSY_STAAM
A:
[6-317]
-
N
S
F
D
A
A
Y
H
S
L
C
E
E
V
L
E
I
G
N
T
R
N
----------
D
R
T
-
N
T
-----
G
--
T
I
S
K
F
G
-
H
Q
L
R
F
--
D
-
L
S
K-
G
-
F
P
L
L
T
T
K
K
V
S
F
K
L
V
A
T
E
L
L
W
F
I
K
G
D
T
-
N
I
Q
Y
L
L
K
Y
N
-
N
N
I
W
N
E
------------
W
A
F
------------
E
N
Y
I
K
SDEYNGPDMTDF
G
H
R
A
L
S
D
P
E
F
N
E
Q
Y
K
E
Q
M
K
Q
F
K
Q
R
I
L
E
D
D
T
F
A
K
Q
F
G
D
L
G
N
V
Y
G
K
Q
---
W
R
D
W
V
------
D
K
D
--------------------------------------
G
N
H
F
D
Q
L
K
T
V
I
E
Q
I
K
H
N
P
D
S
R
R
H
I
V
S
A
W
N
P
T
E
I
D
T
M
A
L
P
P
C
H
T
M
F
Q
F
Y
V
Q
D
------
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
I
A
K
E
C
G
L
E
V
G
E
F
V
H
T
F
G
D
A
H
I
Y
S
N
H
I
D
A
I
Q
T
Q
L
A
R
E
S
F
N
P
P
T
L
K
I
N
S
D
------------
K
S
I
F
---
D
I
N
Y
E
D
L
E
I
V
D
Y
E
S
H
P
A
I
K
A
----