@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38200: (2016-08-03 )
MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFPCALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEFQQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQHAENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRTLADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVYENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGSRMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE
Atome Classification :
(21 SA)
---.........10.....-...20........30.....------...40-.......-.50.....---...60--........70...--...----------...80.--.-.---....-----.----90...----...---..100-------------..-----...-----.---...-------------110........120.---......130.......-140..-.--.---------------.---------------..150.......160.......170.....-..180.......----190---..-.-.-.------...200-------------..-----.---......210.---......220-..--.......230.......240--------------------------------------------------------------------.-------------......250...------------------....--------------------------260----------------......-----.270.......280.-......-------290------........300.......310.-.......320.......330.......340.......350-..-.---......360......-------.370------.........380........390----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
R
E
E
L
K
G
I
F
A
S
V
FGEK-E
G
L
R
F
F
FAPG
R
V
N
L
I
G
EHTD------YNG
G
H
-
V
F
P
C
A
LT-MG
T
Y
A
A
VA---ERND
G
--
L
V
R
MYSDNF-RNA--GIK----------ECSLDD--I-R---YQKE-----D----DWANY----P
K
G
---
V
I
Y
---------------
E
F
-----
Q
QR-----G---YAV-------------P-H
G
F
D
I
V
F
SGNIPN---GAGLSS
S
A
S
I
E
L
L
M
G
V
-
V
L
Q
S
Y-F--H---------------P---------------E
V
D
A
L
E
L
V
K
M
A
Q
HAEN
H
F
I
GVNCG
I
M
D
Q
F
A
-IGMGKK
H
H
A
M
L
L
----NC----DT-L-D-
Y
------
E
YSK---------------LN-----V---S
G
L
A
L
V
I
ANT---NKK
R
T
LA---DS--SYN
T
R
R
Q
E
C
N
D
A
L
L
D
L
K
KGL--------------------------------------------------------------------
D
-------------
I
A
A
LGDIKPSD
F
------------------
D
A
H
S
--------------------------
S
L
I
----------------
Q
N
E
T
N
R
-----
R
R
A
K
H
A
V
Y
ENH
R
A
I
K
-
T
A
H
M
FK-------EN-------
N
I
D
E
I
G
Q
L
M
K
E
SHLSLKDD-YE-VT
C
P
E
L
D
E
L
V
F
A
AWDHEGVIGSRMTGAGFG
G
C
T
I
S
I
V
K
---
D
E
-
F
---
V
D
D
F
I
Q
K
V
G
D
R
Y
Q
E
K-------TG--------LR
A
D
F
Y
V
A
D
I
G-
E
G
A
R
ELKGE------------
31
HHSearch
95.83
47%
-81
- C2 -
1PIE
2
GAL1_LACLA
A:
[32-416]
-----
S
A
L
T
E
K
F
A
E
V
F
G
D
T
-
K
E
V
E
Y
F
F
S
P
G
R
I
N
L
I
G
E
H
T
D
------
Y
N
G
G
Y
-
V
F
P
A
S
I
T
-
I
G
T
T
G
L
A
R
---
L
R
E
D
K
--
K
V
K
L
Y
S
E
N
F
-
P
K
L
--
G
V
I
----------
E
F
D
L
D
E
--
V
-
E
---
K
K
D
G
-----
E
----
L
W
S
N
Y
----
V
K
G
---
M
I
V
---------------
M
L
-----
K
G
A
-----
G
---
Y
E
I
-------------
D
-
K
G
F
E
L
L
I
K
G
E
I
P
T
---
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
-
V
L
D
D
L
-
F
--
N
---------------
L
---------------
N
V
P
R
L
E
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
-
I
G
F
G
E
V
K
K
A
I
E
L
----
D
C
----
N
T
-
L
-
K
-
Y
------
E
M
V
P
---------------
V
E
-----
L
---
R
D
Y
D
I
V
I
M
N
T
---
N
K
P
R
A
L
T
---
E
S
--
K
Y
N
E
R
F
A
E
T
R
E
A
L
K
R
M
Q
T
R
L
--------------------------------------------------------------------
D
-------------
I
Q
S
L
G
E
L
S
N
E
E
F
------------------
D
A
N
T
--------------------------
D
L
I
----------------
G
D
E
T
L
I
-----
K
R
A
R
H
A
V
Y
E
N
N
R
T
K
I
-
A
Q
K
A
F
V
-------
A
G
-------
N
L
T
K
F
G
E
L
L
N
A
S
H
A
S
L
K
D
D
-
Y
E
-
V
T
G
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
---
H
D
-
N
---
V
S
A
F
R
K
A
V
G
Q
V
Y
E
E
V
-------
V
G
--------
Y
P
A
S
F
Y
V
A
Q
I
G
-
S
G
S
T
K
L
---------------
1
PsiBlast_PDB
94.75
47%
-81
- C2 -
1PIE
2
GAL1_LACLA
A:
[38-416]
-----------
F
A
E
V
F
G
D
T
-
K
E
V
E
Y
F
F
S
P
G
R
I
N
L
I
G
E
H
T
D
------
Y
N
G
G
Y
-
V
F
P
A
S
I
T
-
I
G
T
T
G
L
A
R
---
L
R
E
D
K
--
K
V
K
L
Y
S
E
N
F
-
P
K
L
--
G
V
I
----------
E
F
D
L
D
E
--
V
-
E
---
K
K
D
G
-----
E
----
L
W
S
N
Y
----
V
K
G
---
M
I
V
---------------
M
L
-----
K
G
A
-----
G
---
Y
E
I
-------------
D
-
K
G
F
E
L
L
I
K
G
E
I
P
T
---
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
-
V
L
D
D
L
-
F
--
N
---------------
L
---------------
N
V
P
R
L
E
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
-
I
G
F
G
E
V
K
K
A
I
E
L
----
D
C
----
N
T
-
L
-
K
-
Y
------
E
M
V
P
---------------
V
E
-----
L
---
R
D
Y
D
I
V
I
M
N
T
---
N
K
P
R
A
L
T
---
E
S
--
K
Y
N
E
R
F
A
E
T
R
E
A
L
K
R
M
Q
T
R
L
--------------------------------------------------------------------
D
-------------
I
Q
S
L
G
E
L
S
N
E
E
F
------------------
D
A
N
T
--------------------------
D
L
I
----------------
G
D
E
T
L
I
-----
K
R
A
R
H
A
V
Y
E
N
N
R
T
K
I
-
A
Q
K
A
F
V
-------
A
G
-------
N
L
T
K
F
G
E
L
L
N
A
S
H
A
S
L
K
D
D
-
Y
E
-
V
T
G
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
---
H
D
-
N
---
V
S
A
F
R
K
A
V
G
Q
V
Y
E
E
V
-------
V
G
--------
Y
P
A
S
F
Y
V
A
Q
I
G
-
S
G
S
T
K
L
---------------
21
Fugue
82.43
47%
15
- C2 -
1PIE
2
GAL1_LACLA
A:
[29-416]
--T
V
L
S
A
L
T
E
K
F
A
E
V
F
G
D
T
-
K
E
V
E
Y
F
F
S
P
G
R
I
N
L
I
G
E
H
T
D
------
Y
N
G
G
Y
-
V
F
P
A
S
I
T
-
I
G
T
T
G
L
A
R
---
L
R
E
D
K
--
K
V
K
L
Y
S
E
N
F
-
P
K
L
--
G
V
I
----------
E
F
D
L
D
E
--
V
-
E
---
K
K
D
G
-----
E
----
L
W
S
N
Y
----
V
K
G
---
M
I
V
---------------
M
L
-----
K
G
A
-----
G
---
Y
E
I
-------------
D
-
K
G
F
E
L
L
I
K
G
E
I
P
T
---
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
-
V
L
D
D
L
-
F
--
N
---------------
L
---------------
N
V
P
R
L
E
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
-
I
G
F
G
E
V
K
K
A
I
E
L
----
D
C
----
N
T
-
L
-
K
-
Y
------
E
M
V
P
---------------
V
E
-----
L
---
R
D
Y
D
I
V
I
M
N
T
---
N
K
P
R
A
L
T
---
E
S
--
K
Y
N
E
R
F
A
E
T
R
E
A
L
K
R
M
Q
T
R
L
--------------------------------------------------------------------
D
-------------
I
Q
S
L
G
E
L
S
N
E
E
F
------------------
D
A
N
T
--------------------------
D
L
I
----------------
G
D
E
T
L
I
-----
K
R
A
R
H
A
V
Y
E
N
N
R
T
K
I
-
A
Q
K
A
F
V
-------
A
G
-------
N
L
T
K
F
G
E
L
L
N
A
S
H
A
S
L
K
D
D
-
Y
E
-
V
T
G
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
---
H
D
-
N
---
V
S
A
F
R
K
A
V
G
Q
V
Y
E
E
V
-------
V
G
--------
Y
P
A
S
F
Y
V
A
Q
I
G
-
S
G
S
T
K
L
---------------
4
PsiBlast_PDB
81.51
34%
-99
- C2 -
2DEJ
2
GAL1_PYRHO
A:
[6-348]
---------------------------
S
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
T
Y
G
Y
-
V
M
P
M
A
I
N
-
L
--
Y
T
K
I
E
---
A
E
K
H
G
--
E
V
I
L
Y
S
E
H
F
-
G
E
E
----
R
----------
K
F
S
L
N
D
--
L
-
R
-----
K
E
-----
N
----
S
W
I
D
Y
----
V
K
G
---
I
F
W
---------------
V
L
-----
K
E
S
-----
D
---
Y
E
V
---------------
G
G
I
K
G
R
V
S
G
N
L
P
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
-
T
L
D
K
L
-
Y
--
N
---------------
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
-
V
V
F
G
R
E
G
N
V
I
F
L
----
D
T
----
H
T
-
L
-
D
-
Y
------
E
Y
I
P
---------------
F
P
---------
K
D
V
S
I
L
V
F
Y
T
---
G
V
R
-------
S
S
--
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
G
K
G
-------------------------------------------------------------------------------------
S
S
K
E
V
R
E
G
E
L
------------------
S
K
L
P
--------------------------
P
L
---------------------
H
R
-----
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
-
V
R
D
A
L
K
-------
E
G
-------
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
-
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
L
-
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
---
K
E
-
D
---
A
E
T
I
G
E
E
I
L
R
E
Y
L
K
R
-------
F
P
--------
W
K
A
R
H
F
I
V
E
P
S
-
D
G
V
------------------
3
PsiBlast_PDB
81.29
34%
-99
- C2 -
2DEI
2
GAL1_PYRHO
A:
[6-348]
---------------------------
S
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
T
Y
G
Y
-
V
M
P
M
A
I
N
-
L
--
Y
T
K
I
E
---
A
E
K
H
G
--
E
V
I
L
Y
S
E
H
F
-
G
E
E
----
R
----------
K
F
S
L
N
D
--
L
-
R
-----
K
E
-----
N
----
S
W
I
D
Y
----
V
K
G
---
I
F
W
---------------
V
L
-----
K
E
S
-----
D
---
Y
E
V
---------------
G
G
I
K
G
R
V
S
G
N
L
P
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
-
T
L
D
K
L
-
Y
--
N
---------------
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
-
V
V
F
G
R
E
G
N
V
I
F
L
----
D
T
----
H
T
-
L
-
D
-
Y
------
E
Y
I
P
---------------
F
P
---------
K
D
V
S
I
L
V
F
Y
T
---
G
V
R
R
E
L
A
---
S
S
--
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
G
K
G
-------------------------------------------------------------------------------------
S
S
K
E
V
R
E
G
E
L
------------------
S
K
L
P
--------------------------
P
L
---------------------
H
R
-----
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
-
V
R
D
A
L
K
-------
E
G
-------
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
-
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
L
-
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
---
K
E
-
D
---
A
E
T
I
G
E
E
I
L
R
E
Y
L
K
R
-------
F
P
--------
W
K
A
R
H
F
I
V
E
P
S
-
D
G
V
------------------
34
HHSearch
81.22
34%
-97
- C2 -
2CZ9
3
GAL1_PYRHO
A:
[2-350]
-----------------------
I
K
V
K
S
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
T
Y
G
Y
-
V
M
P
M
A
I
N
-
L
Y
T
K
I
E
A
E
---
K
H
G
----
E
V
I
L
Y
S
E
H
F
-
G
E
E
--
R
------------
K
F
S
L
N
D
--
L
------
R
K
E
-----
N
----
S
W
I
D
Y
----
V
K
G
---
I
F
W
---------------
V
L
-----
K
E
S
-----
D
---
Y
-
E
-------------
V
-
G
G
I
K
G
R
V
S
G
N
L
P
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
-
T
L
D
K
L
-
Y
--
N
---------------
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
-
V
V
F
G
R
E
G
N
V
I
F
L
----
D
T
----
H
T
-
L
-
D
-
Y
------
E
Y
I
P
---------------
F
P
---------
K
D
V
S
I
L
V
F
Y
T
---
G
V
R
-------
S
S
--
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
G
K
-------------------------------------------------------------------------------------
G
S
S
K
E
V
R
E
G
E
L
------------------
S
------------------------------
K
L
----------------
P
-
P
L
H
R
-----
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
-
V
R
D
A
L
K
-------
E
G
-------
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
-
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
-
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
---
K
E
-
D
---
A
E
T
I
G
E
E
I
L
R
E
Y
L
K
R
-------
F
P
--------
W
K
A
R
H
F
I
V
E
P
S
-
D
G
V
G
I
----------------
2
PsiBlast_PDB
80.26
34%
-99
- C2 -
2CZ9
3
GAL1_PYRHO
A:
[6-348]
---------------------------
S
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
T
Y
G
Y
-
V
M
P
M
A
I
N
-
L
--
Y
T
K
I
E
---
A
E
K
H
G
--
E
V
I
L
Y
S
E
H
F
-
G
E
E
----
R
----------
K
F
S
L
N
D
--
L
-
R
-----
K
E
-----
N
----
S
W
I
D
Y
----
V
K
G
---
I
F
W
---------------
V
L
-----
K
E
S
-----
D
---
Y
E
V
---------------
G
G
I
K
G
R
V
S
G
N
L
P
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
-
T
L
D
K
L
-
Y
--
N
---------------
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
-
V
V
F
G
R
E
G
N
V
I
F
L
----
D
T
----
H
T
-
L
-
D
-
Y
------
E
Y
I
P
---------------
F
P
---------
K
D
V
S
I
L
V
F
Y
T
---
G
V
R
-------
S
S
--
E
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
G
K
G
-------------------------------------------------------------------------------------
S
S
K
E
V
R
E
G
E
L
------------------
S
K
L
P
--------------------------
P
L
---------------------
H
R
-----
K
F
F
G
Y
I
V
R
E
N
A
R
V
L
E
-
V
R
D
A
L
K
-------
E
G
-------
N
V
E
E
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
-
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
L
-
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
---
K
E
-
D
---
A
E
T
I
G
E
E
I
L
R
E
Y
L
K
R
-------
F
P
--------
W
K
A
R
H
F
I
V
E
P
S
-
D
G
V
------------------
33
HHSearch
70.40
39%
2
- C2 -
1WUU
3
GALK1_HUMAN
A:
[21-398]
-----
A
E
A
R
R
A
F
R
E
E
F
G
A
--
E
P
E
L
A
V
S
A
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
N
Q
G
L
-
V
L
P
M
A
L
E
-
L
M
T
V
L
V
G
S
---
P
R
K
D
G
--
L
V
S
L
L
T
T
S
E
-
G
A
D
EP
Q
R
L
----------
Q
F
P
L
P
T
--
A
-
Q
R
S
L
E
P
G
T
-----
P
----
R
W
A
N
Y
----
V
K
G
---
V
I
Q
---------------
Y
Y
-----
P
A
A
-----------
P
-------------
L
-
P
G
F
S
A
V
V
V
S
S
V
P
L
---
G
G
G
L
S
S
S
A
S
L
E
V
A
T
Y
T
-
F
L
Q
Q
L
-
C
--
P
---------------
D
---------------
S
G
T
I
A
A
R
A
Q
V
C
Q
Q
A
E
H
S
F
A
G
M
P
C
G
I
M
D
Q
F
I
-
S
L
M
G
Q
K
G
H
A
L
L
I
----
D
C
----
R
S
-
L
-
E
-
T
------
S
L
V
P
---------------
L
S
-----
D
---
P
K
L
A
V
L
I
T
N
S
---
N
V
R
H
--
A
---
S
S
--
E
Y
P
V
R
R
R
Q
C
E
E
V
A
R
A
L
G
-------------------------------------------------------------------------------------
K
E
S
L
R
E
V
Q
L
E
E
L
------------------
E
A
A
R
--------------------------
D
L
V
----------------
S
-
K
E
G
F
-----
R
R
A
R
H
V
V
G
E
I
R
R
T
A
Q
-
A
A
A
A
L
R
-------
R
G
-------
D
Y
R
A
F
G
R
L
M
V
E
S
H
R
S
L
R
D
D
-
Y
E
-
V
S
C
P
E
L
D
Q
L
V
E
A
A
L
A
V
P
G
V
Y
G
S
R
M
T
G
G
G
F
G
G
C
T
V
T
L
L
E
---
A
S
-
A
---
A
P
H
A
M
R
H
I
Q
E
H
Y
-----------
G
--------
G
T
A
T
F
Y
L
S
Q
A
A
-
D
G
A
K
V
L
C
--------------
5
PsiBlast_PDB
69.32
36%
9
- C2 -
1WUU
3
GALK1_HUMAN
A:
[22-397]
------
E
A
R
R
A
F
R
E
E
F
G
A
E
-
P
E
L
-
A
V
S
A
P
G
R
V
N
L
I
G
E
H
T
D
------
Y
N
Q
G
L
-
V
L
P
M
A
L
E
-
L
M
T
V
L
V
G
S
---
P
R
K
D
G
--
L
V
S
L
L
T
T
S
E
-
G
A
D
--
E
P
Q
----------
R
L
Q
F
P
L
--
P
-
T
---
A
Q
R
S
L
E
PGT
P
----
R
W
A
N
Y
----
V
K
G
---
V
I
Q
---------------
Y
Y
-----
P
------------
A
A
-------------
P
L
P
G
F
S
A
V
V
V
S
S
V
P
L
---
G
G
G
L
S
S
S
A
S
L
E
V
A
T
Y
T
-
F
L
Q
Q
L
-
C
--
P
---------------
D
---------------
S
G
T
I
A
A
R
A
Q
V
C
Q
Q
A
E
H
S
F
A
G
M
P
C
G
I
M
D
Q
F
I
-
S
L
M
G
Q
K
G
H
A
L
L
I
----
D
C
----
R
S
-
L
-
E
-
T
------
S
L
V
P
---------------
L
S
-----
D
---
P
K
L
A
V
L
I
T
N
S
---
N
V
R
H
--
A
---
S
S
--
E
Y
P
V
R
R
R
Q
C
E
E
----
V
A
R
A
L
--------------------------------------------------------------------
G
-------------
K
E
S
L
R
E
V
Q
L
E
E
L
------------------
E
A
A
R
--------------------------
D
L
V
----------------
S
K
E
-
G
F
-----
R
R
A
R
H
V
V
G
E
I
R
R
T
A
Q
-
A
A
A
A
L
R
-------
R
G
-------
D
Y
R
A
F
G
R
L
M
V
E
S
H
R
S
L
R
D
D
-
Y
E
-
V
S
C
P
E
L
D
Q
L
V
E
A
A
L
A
V
P
G
V
Y
G
S
R
M
T
G
G
G
F
G
G
C
T
V
T
L
L
E
---
A
S
-
A
---
A
P
H
A
M
R
H
I
----
Q
E
H
-------
Y
G
--------
G
T
A
T
F
Y
L
S
Q
A
A
-
D
G
A
K
V
L
---------------
35
HHSearch
60.86
26%
-4
- C2 -
3V2U
4
GAL3_YEAST
C:
[24-519]
-----
L
A
V
V
D
A
F
F
Q
T
Y
H
V
--
K
P
D
F
I
A
R
S
P
G
R
V
N
L
I
G
E
H
I
D
------
Y
C
D
F
S
-
V
L
P
L
A
I
D
-
V
D
M
L
C
A
V
K
---
I
L
D
E
K
N
P
S
I
T
L
T
N
A
D
P
-
K
F
A
Q
-
R
K
F
----------
D
L
P
L
D
G
S
Y
M
A
I
---
D
P
S
V
-----
S
----
E
W
S
N
Y
----
F
K
C
---
G
L
H
V
A
H
S
-----------
Y
L
-----
K
K
I
APERF
N
---
N
T
P
-------------
L
-
V
G
A
Q
I
F
C
Q
S
D
I
P
T
---
G
G
G
L
S
S
A
F
T
C
A
A
A
L
A
T
--
I
R
A
N
-
M
GK
N
---------------
F
---------------
D
I
S
K
K
D
L
T
R
I
T
A
V
A
E
H
Y
-
V
G
V
N
N
G
G
M
D
Q
A
T
-
S
V
Y
G
E
E
D
H
A
L
Y
V
----
E
F
----
R
P
-
K
L
K
-
A
------
T
P
F
K
---------------
F
P
-----
Q
LKN
H
E
I
S
F
V
I
A
N
T
---
L
V
K
S
N
K
F
ETA
P
T
--
N
Y
N
L
R
V
I
E
V
T
V
A
A
N
A
L
A
T
R
Y
--------------------------------------------------------------------
S
V
A
L
P
S
H
KDNSNSE
R
G
N
L
R
D
F
M
D
A
Y
Y
A
R
YENQAQPWNGD
I
G
T
G
I
E
R
L
L
K
M
L
Q
L
V
E
E
S
FSRKKSGFT
V
H
E
A
S
T
A
L
N
C
S
R
E
E
F
T
R
D
YLTT
F
P
V
R
F
Q
V
L
K
L
Y
-----
Q
R
A
K
H
V
Y
S
E
S
L
R
V
L
K
-
A
L
K
M
M
T
-------
S
A
T
F
H
T
D
E
D
F
F
T
D
F
G
R
L
M
N
E
S
Q
A
S
C
D
K
L
-
Y
E
-
C
S
C
I
E
T
N
Q
I
C
S
I
A
L
A
-
N
G
S
F
G
S
R
L
T
G
A
G
W
G
G
C
T
I
H
L
V
P
---
S
G
-
A
NGN
V
E
Q
V
R
K
A
L
I
E
K
F
Y
N
V
--------
R
YPDLT
D
E
E
L
K
D
A
I
I
V
S
K
P
A
-
L
G
T
C
L
Y
E
--------------
23
Fugue
54.45
26%
15
- C2 -
3V5R
16
GAL3_YEAST
A:
[4-505]
F
E
Q
K
H
L
A
V
V
D
A
F
F
Q
T
Y
H
V
K
-
P
D
F
-
I
A
R
S
P
G
R
V
N
L
I
G
E
H
I
D
------
Y
C
D
F
S
-
V
L
P
L
A
I
D
-
V
D
M
L
C
A
V
K
---
I
L
D
E
K
N
P
S
I
T
L
T
N
A
D
P
-
K
F
A
--
Q
R
K
----------
F
D
L
P
L
D
--
G
-
S
---
Y
M
A
I
-----
D
PSVS
E
W
S
N
Y
F
K
C
G
L
H
V
---
A
H
S
---------------
Y
L
-----
K
K
I
-----
A
---
P
E
R
FNNTP--------
L
-
V
G
A
Q
I
F
C
Q
S
D
I
P
T
---
G
G
G
L
S
S
A
F
T
C
A
A
A
L
A
T
-
I
R
A
N
M
G
K
--
N
---------------
F
---------------
D
I
S
K
K
D
L
T
R
I
T
A
V
A
E
-
H
Y
V
G
V
N
N
G
G
M
D
Q
A
T
-
S
V
Y
G
E
E
D
H
A
L
Y
V
----
E
F
RPKL
K
A
-
T
-
P
-
F
------
K
F
P
Q
---------------
L
K
-----
N
---
H
E
I
S
F
V
I
A
N
T
---
L
V
K
S
N
K
A
---
P
T
--
N
Y
N
L
R
V
I
E
V
T
V
A
A
N
A
L
A
T
R
Y
S
V
A
L
P
S
HKDNSNSERGN
L
R
D
F
M
D
A
Y
Y
A
R
YENQAQPWNGD
I
G
T
G
I
E
R
L
L
K
M
L
Q
L
V
E
E
S
FSRKKS
G
F
T
V
H
E
-------------
A
S
T
A
L
N
C
S
R
E
E
F
------------------
T
R
D
Y
--------------------------
L
T
T
----------------
F
P
V
R
F
Q
VLK
L
Y
Q
R
A
K
H
V
Y
S
E
S
L
R
V
L
K
-
A
L
K
M
M
T
SATFHT
D
E
D
-------
F
F
T
D
F
G
R
L
M
N
E
S
Q
A
S
C
D
K
L
-
Y
E
-
C
S
C
I
E
T
N
Q
I
C
S
I
A
L
A
N
-
G
S
F
G
S
R
L
T
G
A
G
W
G
G
C
T
I
H
L
V
P
S
G
A
N
G
-
N
---
V
E
Q
V
R
K
A
L
I
E
K
F
Y
N
V
RYPDLT
D
E
E
--------
L
K
D
A
I
I
V
S
K
P
A
-
L
G
T
C
L
Y
E
Q
-------------
42
HHSearch
53.56
20%
-17
- C2 -
4HAC
1
?
A:
[10-320]
-----------
H
S
S
G
L
V
P
R
G
S
H
M
V
S
C
S
A
P
G
K
I
Y
L
F
G
E
H
A
V
------
V
Y
G
E
T
-
A
I
A
C
A
V
E
-
L
R
T
R
V
R
A
E
---
L
N
D
S
----
I
T
I
Q
S
Q
-
I
-
G
R
-----------------
T
G
L
-------------
D
-----
F
----
E
K
H
P
Y
----
V
S
A
---
V
I
E
---------------
K
M
-----
R
K
S
-----
I
-----
P
-------------
I
-
N
G
V
F
L
T
V
D
S
D
I
P
V
---
G
S
G
L
G
S
S
A
A
V
T
I
A
S
I
G
-
A
L
N
E
L
-
F
--
G
---------------
F
---------------
G
L
S
L
Q
E
I
A
K
L
G
H
E
I
E
I
K
V
Q
G
A
A
-
S
P
T
D
T
Y
V
-
S
T
F
G
G
V
---
V
T
I
----
P
E
----
R
R
---------------
K
---------------
L
K
-----
T
---
P
D
C
G
I
V
I
G
D
T
---
G
V
F
S
S
T
K
---
E
----
L
V
-------
A
N
V
R
Q
L
R
------------------------------------------------------------------------------------------
E
S
Y
P
D
L
I
------------------------------------------------------------------------------
E
P
L
M
T
S
I
G
K
I
--
S
R
I
-
G
E
Q
L
V
L
-------
S
G
-------
D
Y
A
S
I
G
R
L
M
N
V
N
Q
G
L
L
D
A
--
L
G
-
V
N
I
L
E
L
S
Q
L
I
Y
S
A
R
A
-
A
G
A
F
G
A
K
I
T
G
A
G
G
G
G
C
M
V
A
L
T
A
---
P
E
-
K
---
C
N
Q
V
A
E
A
V
A
G
A
----------------------
G
G
K
V
T
I
T
K
P
T
E
Q
G
L
K
V
----------------
25
Fugue
51.92
21%
-12
- C2 -
1KVK
2
KIME_RAT
A:
[1-394]
-----------------
M
L
-
S
E
V
L
L
V
S
A
P
G
K
V
I
L
H
G
E
H
A
V
------
V
H
G
K
V
-
A
L
A
V
A
L
N
-
L
R
T
F
L
V
L
R
---
P
Q
S
N
G
--
K
V
S
L
N
L
P
N
V
G
I
K
Q
--
V
W
D
----------
V
A
T
L
Q
L
--
L
-
D
---
T
E
K
L
-----
K
----
K
V
A
G
L
----
P
R
D
---
C
V
G
---------------
N
E
-----
G
L
S
-----
L
---
L
A
F
L
Y
L
Y
L
A
I
CRKQR
T
L
-
P
S
L
D
I
M
V
W
S
E
L
P
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
-
A
L
L
T
A
-
C
--
E
EVTNPLKDRGS
I
G
S
W
P
---------------
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
-
V
D
N
S
V
-
S
T
W
G
G
-----
A
L
----
R
Y
----
Q
Q
-
G
-
K
-
M
------
S
S
L
K
----------------
R
-----
L
---
P
A
L
Q
I
L
L
T
N
T
---
K
V
P
R
S
T
K
---
A
L
--
V
A
G
V
R
S
R
L
I
K
F
P
E
I
M
A
P
L
L
T
--------------------------------------------------------------------
S
-------------
I
D
A
I
S
L
E
C
E
R
V
L
------------------
G
E
M
A
--------------------------
A
------------------------------------------------
A
P
V
-------
P
E
-------
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
N
A
--
L
G
-
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
H
G
--
L
H
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
L
K
---
P
G
-
L
---
E
R
A
K
V
E
A
A
K
Q
A
L
T
G
C
------------------
G
F
D
C
W
E
T
S
I
G
-
A
P
G
V
S
M
H
S
A
TSIE
D
P
V
R
Q
A
L
G
38
HHSearch
50.56
22%
12
- C2 -
1KVK
2
KIME_RAT
A:
[4-382]
---------------------
E
V
L
L
V
S
A
P
G
K
V
I
L
H
G
E
H
A
V
------
V
H
G
K
V
-
A
L
A
V
A
L
N
-
L
R
T
F
L
V
L
R
---
P
Q
S
N
G
--
K
V
S
L
N
L
P
N
V
-
G
I
K
--
Q
V
W
D
V
A
T
L
Q
L
LDT---------------
E
K
L
-----
K
----
K
V
A
G
L
----
P
R
D
---
C
V
G
NE
G
L
S
L
L
A
F
L
Y
L
Y
L
A
I
C
-----
R
K
------
Q
----
R
T
-------------
L
-
P
S
L
D
I
M
V
W
S
E
L
P
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
-
A
L
L
T
A
-
C
--
E
---------------
E
VTNPLKDRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
V
-
D
N
S
V
-
S
T
W
G
G
A
---
L
R
Y
----
Q
Q
----
G
K
-
M
-
S
---------
S
L
K
----------------
R
-----
L
---
P
A
L
Q
I
L
L
T
N
T
---
K
V
P
R
S
T
K
---
A
L
V
A
G
V
R
S
R
L
I
K
F
P
-----------------------------------------------------------------------------------------------------
E
I
M
------------------
A
P
L
---------------------------------------------------
L
-----
T
S
I
D
A
I
S
L
E
C
E
R
V
L
G
E
M
A
A
A
P
V
-------
P
E
-------
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
N
A
--
L
G
-
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
G
-
L
H
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
L
K
---
P
G
-
L
---
E
R
A
K
V
E
A
A
K
Q
A
L
T
G
--------
C
G
----------
F
D
C
W
E
T
S
I
G
A
P
G
V
S
M
H
S
A
-------------
24
Fugue
50.31
17%
-90
- C2 -
2OI2
2
?
A:
[4-292]
---------------------
K
V
G
V
G
Q
A
H
S
K
I
I
L
I
G
E
H
A
V
------
V
Y
G
Y
P
-
A
I
S
L
P
L
L
-
E
V
E
V
T
C
K
V
---
V
P
A
E
------------------------------------------------------
S
----
P
W
R
L
Y
----
E
E
D
---
T
L
S
---------------
M
A
-----
V
Y
A
-----
S
---
L
E
Y
-------------
L
-
N
I
T
E
A
C
I
R
C
E
I
D
E
---
K
R
G
M
G
S
S
A
A
I
S
I
A
A
I
R
-
A
V
F
D
Y
-
Y
--
Q
---------------
A
---------------
D
L
P
H
D
V
L
E
I
L
V
N
R
A
E
M
I
A
H
M
N
P
S
G
-
L
D
A
K
T
-
C
L
S
D
Q
P
----
I
R
----
F
I
----
K
N
-
V
-
G
-
F
------
T
E
L
E
---------------
M
D
---------
L
S
A
Y
L
V
I
A
D
T
---
G
V
Y
G
H
T
R
---
E
A
--
I
Q
V
V
Q
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
-----
D
A
L
P
F
L
H
A
L
G
E
L
T
Q
Q
-
A
E
I
A
I
S
-------
Q
K
-------
D
A
E
G
L
G
Q
I
L
S
Q
A
H
L
H
L
K
E
--
I
G
-
V
S
S
L
E
A
D
S
L
V
E
T
A
L
S
H
-
G
A
L
G
A
K
M
S
G
G
G
L
G
G
C
I
I
A
L
V
T
N--
L
T
-
H
---
A
Q
E
L
A
E
R
L
E
E
K
G
A
V
Q
-------
T
W
--------
I
E
S
L
-----------------------------
39
HHSearch
49.80
19%
-3
- C2 -
4USK
6
?
A:
[4-344]
---------------------
T
I
I
R
A
R
A
P
L
R
L
G
L
A
G
G
G
T
D
V
A
P
Y
A
D
T
F
G
G
Y
-
V
L
N
A
T
I
D
-
R
Y
A
Y
A
V
I
K
---
T
L
T
I
P
--
A
V
R
F
V
S
T
D
Q
-
Q
V
E
---------------
K
H
Q
L
I
S
----
E
---
P
L
E
L
-----
N
----
G
T
L
N
L
----
H
K
A
---
V
Y
N
---------------
H
M
-----
I
R
N
Y----
N
---
H
G
K
-------------
P
-
I
A
L
E
L
S
T
F
C
D
A
P
A
---
G
S
G
L
G
S
S
S
T
L
V
V
V
M
I
K
-
A
F
V
E
L
-
L
--
N
---------------
L
---------------
P
L
D
D
Y
A
I
A
Q
L
A
Y
R
I
E
R
V
D
C
G
L
A
G
G
R
Q
D
Q
Y
S
-
A
T
F
G
G
F
N
F
M
E
F
Y
----
A
A
----
A
R
-
T
-
I
-
V
------
N
P
L
R
---------------
I
K
N
W
V
L
C
E
---
L
E
A
S
L
V
L
F
Y
T
---
G
V
S
R
E
S
A
---
K
--------------
I
I
Q
D
Q
S
D
N
V
--------------------------------------------------------------------
V
-----------------
S
--
H
K
T
A
A
------------------------------------------------------------------------------
I
E
A
M
H
G
I
K
R
E
--
A
L
V
-
M
K
E
A
L
L
-------
K
G
-------
D
F
K
A
F
V
A
S
M
R
L
G
W
D
N
K
K
N
S
A
R
T
-
V
S
N
A
H
I
D
E
I
Y
D
A
A
I
R
-
A
G
A
Q
A
G
K
V
S
G
A
G
G
G
G
F
M
L
F
F
V
P
---
T
E
-
K
---
R
M
D
L
I
R
T
L
G
E
Y
----------------------
D
G
Q
V
S
N
C
H
F
T
K
N
G
T
Q
A
W
R
I
-------------
27
Fugue
47.53
17%
-81
* C2 *
1H74
2
KHSE_METJA
A:
[1-296]
---
M
K
V
R
V
K
A
P
C
T
S
A
---------------------------------------
N
L
G
V
G
-
F
D
V
F
G
L
C
L
---
K
E
P
Y
D
--
V
I
E
V
E
A
I
D
D
-
K
E
I
--
I
I
E
----------
V
----
D
--
D
-
K
---
N
I
P
T
-----
D
----
P
D
K
N
V
----
A
G
I
---
V
A
K
---------------
K
M
-----
I
D
D
---------
F
N
I
-------------
G
-
K
G
V
K
I
T
I
K
K
G
V
K
A
---
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
-
A
I
N
E
L
-
F
--
K
---------------
L
---------------
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
L
A
S
S
G
A
--
K
H
A
D
N
V
A
-
P
A
I
F
--------------------------------------------------------------
G
G
F
T
M
V
T
N
Y
E
---
P
L
E
V
L
H
I
---
P
------------------
I
D
F
K
L
--------------------------------------------------------------------
D
-------------
I
L
I
A
---
I
P
N
I
S
------------------
I
N
T
K
--------------------------
E
A
R
----------------
E
I
L
P
K
A
-----
V
G
L
K
D
L
V
N
N
V
G
K
A
C
G
-
M
V
Y
A
L
Y
-------
N
K
-------
D
K
S
L
F
G
R
Y
M
M
S
D
K
V
I
-
E
P
V
-
R
G
-
K
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
K
--
V
Y
G
I
T
I
S
G
S
G
P
S
--
I
I
A
F
P
K
---
E
E
-
F
---
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
----------------------
T
I
R
T
E
V
G
-
K
G
V
E
V
V
---------------
29
Fugue
47.07
16%
-82
- C2 -
1FWK
1
KHSE_METJA
A:
[1-296]
---
M
K
V
R
V
K
A
P
C
T
S
A
-----------------
N
L
----------------------
G
V
G
-
F
D
V
F
G
L
C
L
---
K
E
P
Y
D
--
V
I
E
V
E
A
I
D
D
-
K
E
I
--
I
I
E
----------
V
-
D
D
K
N
--
I
-
P
---
T
D
P
D
-----
K
----
N
V
A
G
I
----
V
A
K
---
K
M
I
---------------
D
D
-----
F
N
I
-------------------------
G
-
K
G
V
K
I
T
I
K
K
G
V
K
A
---
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
-
A
I
N
E
L
-
F
--
K
---------------
L
---------------
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
L
A
S
S
G
A
--
K
H
A
D
N
V
A
-
P
A
I
F
--------------------------------------------------------------
G
G
F
T
M
V
T
N
Y
E
---
P
L
E
V
L
H
I
---
P
I
--
D
-----
F
K
L
D
I
L
I
A
I
P
N
I
S
I
--------------------------------------------------------------------
N
-------------
T
K
E
A
R
E
I
L
P
K
A
V
------------------
G
-------------------------------------------------------------
L
K
D
L
V
N
N
V
G
K
A
C
G
-
M
V
Y
A
L
Y
-------
N
K
-------
D
K
S
L
F
G
R
Y
M
M
S
D
K
V
I
E
P
V
R
-
G
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
--
K
D
K
V
Y
G
I
T
I
S
G
S
G
P
S
--
I
I
A
F
P
K
---
E
E
-
F
---
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
----------------------
T
I
R
T
E
V
G
-
K
G
V
E
V
V
---------------
45
HHSearch
44.28
16%
-18
- C2 -
3GON
3
?
A:
[2-317]
-----------------------
I
A
V
K
T
C
G
K
L
Y
W
A
G
E
Y
A
I
------
L
E
P
G
Q
L
A
L
I
K
D
I
P
-
I
Y
M
R
A
E
I
A
---
F
S
D
S
Y
--
R
I
Y
--
S
D
M
F
-
D
F
A
----------------
V
D
------------
L
R
P
-----
N
----
P
D
Y
S
L
----
I
Q
E
---
T
I
A
---------------
L
M
-----
G
D
F
-----
L
A
V
R
G
Q
N
-------------
L
-
R
P
F
S
L
A
I
Y
G
K
M
E
R
EGK
K
F
G
L
G
S
S
G
S
V
V
V
L
V
V
K
-
A
L
L
A
L
-
Y
--
N
---------------
L
---------------
S
V
D
Q
N
L
L
F
K
L
T
S
A
V
L
L
K
-
R
G
D
N
G
S
M
G
D
L
A
C
-
I
A
A
E
D
L
---
V
L
Y
----
Q
S
----
F
D
-
R
-
Q
K
V
A
A
W
L
E
E
E
N
L
A
T
V
L
E
RDWG
F
S
I
S
Q
V
K
P
T
---------
L
E
C
D
F
L
V
G
W
T
---
K
E
V
A
V
S
S
---
H
--------------
M
V
Q
Q
I
K
Q
N
I
--------------------------------------------------------------------
N
----------------------
Q
N
---------------------
F
---------------------------------------------------
L
-----
T
S
S
K
E
------
T
V
V
S
-
L
V
E
A
L
E
-------
Q
G
-------
K
S
E
K
I
I
E
Q
V
E
V
A
S
K
L
L
E
G
L
-
S
T
D
I
Y
T
P
L
L
R
Q
L
K
E
A
S
Q
D
-
L
Q
A
-
V
A
K
S
S
G
A
G
G
G
D
C
G
I
A
L
S
F
---
D
A
Q
S
---
T
K
T
L
K
N
R
W
A
--------------------------------------------------------
47
HHSearch
44.17
19%
-18
- C2 -
4P52
-
?
A:
[2-309]
--------------------
K
D
S
I
K
V
F
A
P
A
T
V
A
N
V
S
-----------
C
G
F
D
-
V
L
G
F
A
V
D
N
P
G
D
E
V
L
L
R
---
L
S
D
K
K
--
G
V
R
I
T
S
I
T
G
-
D
D
G
---------------
R
L
--------
P
-----
K
D
-----
A
----
E
K
N
T
V
----
S
I
S
---
I
L
R
---------------
Y
L
-----
E
T
L
-----
G
-----
I
-------------
E
-
Q
G
I
E
I
E
L
T
K
K
M
P
L
---
G
S
G
L
G
S
S
A
A
S
T
V
A
G
V
Y
-
A
I
N
Q
L
-
L
--
G
---------------
N
---------------
K
M
E
V
K
D
L
L
P
F
A
M
E
G
E
F
L
A
C
G
--
S
A
H
A
D
N
V
A
P
C
L
Y
G
G
F
---
V
L
V
----
R
S
----
Y
D
P
L
-
D
-
V
------
V
K
L
P
---------------
V
P
---------
A
N
L
Y
A
T
I
I
H
P
---
H
V
E
V
Q
T
K
---
D
-----------
A
R
N
I
L
P
K
Q
-----------------------------------------------------------------------------------------------
I
A
L
---------------------------------------------------------------------------------
S
Q
A
V
A
Q
W
G
N
V
G
G
-
L
V
A
G
L
L
-------
M
N
-------
D
T
S
L
I
G
R
S
M
Q
D
H
--
I
V
E
P
A
-
R
S
-
V
L
I
P
G
F
D
D
V
K
K
A
A
L
D
-
A
G
A
L
G
C
S
I
S
G
S
G
--
P
S
I
F
A
L
S
T
---
S
Q
-
E
A
--
A
Q
K
I
G
Q
A
M
K
K
G
F
D
A
--------
I
N
--------
I
G
S
D
V
Y
V
S
T
V
N
Q
Q
G
P
K
V
I
---------------
6
PsiBlast_PDB
31.94
30%
-13
- C2 -
2AJ4
4
GAL1_YEAST
A:
[70-314]
---------------------------
S
P
G
R
V
N
L
I
G
E
H
I
D
------
Y
C
D
F
S
-
V
L
P
L
A
I
D
-
F
D
M
L
C
A
V
K
V
L
N
E
K
N
P
S
--
I
T
L
I
N
A
D
P
K
-
F
A
Q
--
R
K
F
----------
D
L
P
L
D
G
----
S
---
Y
V
T
I
-----
D
PSVS
D
W
S
N
Y
----
F
K
C
G
L
H
V
A
H
---------------
S
F
L
K
K
L
A
P
E
R
-----
F
---
A
S
A
-------------
P
L
A
G
L
Q
V
F
C
E
G
D
V
P
T
---
G
S
G
L
S
S
S
A
A
F
I
C
A
V
A
L
A
V
V
K
A
N
-
M
--
G
---------------
P
G
Y
-------------
H
M
S
K
Q
N
L
M
R
I
T
V
V
A
E
-
H
Y
V
G
V
N
N
G
G
M
D
Q
A
A
-
S
V
C
G
E
E
D
H
A
L
Y
V
EFKP
Q
L
----
K
A
-
T
-
P
-
F
------
K
F
P
Q
---------------
L
K
-----
N
---
H
E
I
S
F
V
I
A
N
T
LVV
S
N
K
F
E
T
A
---
P
T
--
N
Y
N
L
R
V
V
E
V
T
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------