@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0414c: (2016-04-22 )
MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDKGSPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDLPVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLVRVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTAAN
Atome Classification :
(26 SA)
-------.........-10........--20--........30........40.....---...50........60........70........80........90........100.......110.......120..---.....130..-.....140.......--150.--..-...-..160.....----..170.---......180......----.--------190..----.....200.......210.......220---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------M
H
E
S
RLAS
A
-
R
L
Y
L
C
T
D
A
R
R--ER--G
D
L
A
Q
F
A
E
A
A
LAGG
V
D
I
I
Q
L
RDKGS---PGE
L
R
FGP
L
Q
A
R
D
E
L
A
A
C
E
I
L
A
D
A
A
H
RY
G
A
L
F
A
VNDR
A
D
I
A
R
AAGA
D
V
LHLGQRDL
P
V
N
V
A
R
Q
ILAPDTLIGRSTH
D
P
---
D
Q
V
A
A
AAAGD-A
D
Y
F
C
VGPCWPTPTK--P-GR--AA-PG
L
-
G
L
V
R
V
A
A
E
LG----GDDK
P
W
---
F
A
IGGI
N
A
Q
R
L
P
A
V
L
----
D
--------AGA
R
R
----
I
V
V
V
R
A
ITSADD
P
R
A
A
A
E
Q
L
R
S
A
L
TAAN---
59
HHSearch
99.25
100%
-135
- C2 -
3O63
1
THIE_MYCTU
A:
[22-242]
-------
M
H
E
S
R
L
A
S
A
-
R
L
Y
L
C
T
D
A
R
R
--
E
R
--
G
D
L
A
Q
F
A
E
A
A
L
A
G
G
V
D
I
I
Q
L
R
D
K
G
S
---
P
G
E
L
R
F
G
P
L
Q
A
R
D
E
L
A
A
C
E
I
L
A
D
A
A
H
R
Y
G
A
L
F
A
V
N
D
R
A
D
I
A
R
A
A
G
A
D
V
L
H
L
G
Q
R
D
L
P
V
N
V
A
R
Q
I
L
A
P
D
T
L
I
G
R
S
T
H
D
P
---
D
Q
V
A
A
A
A
A
G
D
-
A
D
Y
F
C
V
G
P
C
W
P
T
P
T
----------
A
-
P
G
L
-
G
L
V
R
V
A
A
E
L
-------
D
K
P
W
---
F
A
I
G
G
I
N
A
Q
R
L
P
A
V
L
----
D
--------
A
G
A
R
R
----
I
V
V
V
R
A
I
T
S
A
D
D
P
R
A
A
A
E
Q
L
R
S
A
L
T
A
A
----
1
PsiBlast_PDB
99.25
100%
-135
- C2 -
3O63
1
THIE_MYCTU
A:
[22-242]
-------
M
H
E
S
R
L
A
S
A
-
R
L
Y
L
C
T
D
A
R
R
--
E
R
--
G
D
L
A
Q
F
A
E
A
A
L
A
G
G
V
D
I
I
Q
L
R
D
K
G
S
---
P
G
E
L
R
F
G
P
L
Q
A
R
D
E
L
A
A
C
E
I
L
A
D
A
A
H
R
Y
G
A
L
F
A
V
N
D
R
A
D
I
A
R
A
A
G
A
D
V
L
H
L
G
Q
R
D
L
P
V
N
V
A
R
Q
I
L
A
P
D
T
L
I
G
R
S
T
H
D
P
---
D
Q
V
A
A
A
A
A
G
D
-
A
D
Y
F
C
V
G
P
C
W
P
T
P
T
----------
A
-
P
G
L
-
G
L
V
R
V
A
A
E
L
-------
D
K
P
W
---
F
A
I
G
G
I
N
A
Q
R
L
P
A
V
L
----
D
--------
A
G
A
R
R
----
I
V
V
V
R
A
I
T
S
A
D
D
P
R
A
A
A
E
Q
L
R
S
A
L
T
A
A
----
21
PsiBlast_CBE
96.05
100%
-134
- C2 -
3O63
1
THIE_MYCTU
B:
[22-242]
-------
M
H
E
S
R
L
A
S
A
-
R
L
Y
L
C
T
D
A
R
R
--
E
R
--
G
D
L
A
Q
F
A
E
A
A
L
A
G
G
V
D
I
I
Q
L
R
D
K
G
S
---
P
G
E
L
R
F
G
P
L
Q
A
R
D
E
L
A
A
C
E
I
L
A
D
A
A
H
R
Y
G
A
L
F
A
V
N
D
R
A
D
I
A
R
A
A
G
A
D
V
L
H
L
G
Q
R
D
L
P
V
N
V
A
R
Q
I
L
A
P
D
T
L
I
G
R
S
T
H
D
P
---
D
Q
V
A
A
A
A
A
G
D
-
A
D
Y
F
C
V
G
P
C
W
P
-------------
A
-
P
G
L
-
G
L
V
R
V
A
A
E
L
-------
D
K
P
W
---
F
A
I
G
G
I
N
A
Q
R
L
P
A
V
L
----
D
--------
A
G
A
R
R
----
I
V
V
V
R
A
I
T
S
A
D
D
P
R
A
A
A
E
Q
L
R
S
A
L
T
A
A
----
61
HHSearch
74.64
36%
-112
* C2 *
1XI3
2
THIE_PYRFU
A:
[13-212]
-------------
N
K
L
-
K
L
Y
V
I
T
D
R
R
L
--
K
P
----
E
V
E
S
V
R
E
A
L
E
G
G
A
T
A
I
Q
M
R
I
K
N
A
---
P
T
R
---------
E
M
Y
E
I
G
K
T
L
R
Q
L
T
R
E
Y
D
A
L
F
F
V
D
D
R
V
D
V
A
L
A
V
D
A
D
G
V
Q
L
G
P
E
D
M
P
I
E
V
A
K
E
I
-
A
P
N
L
I
I
G
A
S
V
Y
S
L
---
E
E
A
L
E
A
E
K
K
G
-
A
D
Y
L
G
A
G
S
V
F
P
T
-------
D
A
--
R
V
-
I
G
L
-
E
G
L
R
K
I
V
E
------
S
V
K
I
P
V
---
V
A
I
G
G
I
N
K
D
N
A
R
E
V
L
----
K
--------
T
G
V
D
G
----
I
A
V
I
S
A
V
M
G
A
E
D
V
R
K
A
T
E
E
L
R
K
I
V
E
E
-----
22
PsiBlast_CBE
74.62
35%
-118
- C2 -
1XI3
3
THIE_PYRFU
B:
[16-210]
-----------------
K
L
Y
V
I
T
D
-
R
R
--
L
K
--
P
E
V
E
S
V
R
E
A
-
L
E
G
G
A
T
A
I
Q
M
R
I
K
N
A
---
P
---------
T
R
E
M
Y
E
I
G
K
T
L
R
Q
L
T
R
E
Y
D
A
L
F
F
V
D
D
R
V
D
V
A
L
A
V
D
A
D
G
V
Q
L
G
P
E
D
M
P
I
E
V
A
K
E
I
-
A
P
N
L
I
I
G
A
S
V
Y
S
L
---
E
E
A
L
E
A
E
K
K
G
-
A
D
Y
L
G
A
G
S
V
F
P
T
-------
D
A
--
R
V
-
I
G
L
E
G
L
R
K
I
V
E
S
V
-------
K
I
P
V
---
V
A
I
G
G
I
N
K
D
N
A
R
E
V
L
----
K
--------
T
G
V
D
G
----
I
A
V
I
S
A
V
M
G
A
E
D
V
R
K
A
T
E
E
L
R
K
I
V
-------
2
PsiBlast_PDB
74.24
35%
-117
- C2 -
1XI3
2
THIE_PYRFU
A:
[16-210]
-----------------
K
L
Y
V
I
T
D
-
R
R
--
L
K
--
P
E
V
E
S
V
R
E
A
-
L
E
G
G
A
T
A
I
Q
M
R
I
K
N
A
---
P
---------
T
R
E
M
Y
E
I
G
K
T
L
R
Q
L
T
R
E
Y
D
A
L
F
F
V
D
D
R
V
D
V
A
L
A
V
D
A
D
G
V
Q
L
G
P
E
D
M
P
I
E
V
A
K
E
I
-
A
P
N
L
I
I
G
A
S
V
Y
S
L
---
E
E
A
L
E
A
E
K
K
G
-
A
D
Y
L
G
A
G
S
V
F
P
T
-------
D
A
--
R
V
-
I
G
L
E
G
L
R
K
I
V
E
S
V
-------
K
I
P
V
---
V
A
I
G
G
I
N
K
D
N
A
R
E
V
L
----
K
--------
T
G
V
D
G
----
I
A
V
I
S
A
V
M
G
A
E
D
V
R
K
A
T
E
E
L
R
K
I
V
-------
49
Fugue
71.43
28%
-104
- C2 -
2TPS
3
THIE_BACSU
A:
[2-227]
HGIRMTR
I
S
R
E
M
M
K
E
L
L
S
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
---
D
------
A
L
T
G
E
A
R
I
K
F
A
E
K
A
Q
A
A
C
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
-
G
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
-
D
T
--
R
A
-
V
Q
G
-
V
S
L
I
E
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
Q
T
Y
K
T
G
R
48
Fugue
71.06
27%
-102
- C2 -
1G67
4
THIE_BACSU
A:
[1-225]
-GIRMTR
I
S
R
E
M
M
K
E
L
L
S
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
---------
D
A
L
T
G
E
A
R
I
K
F
A
E
K
A
Q
A
A
C
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
-
G
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
-
D
T
--
R
A
-
V
Q
G
-
V
S
L
I
E
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
Q
T
Y
K
T
G
R
62
HHSearch
69.28
29%
-105
- C2 -
2TPS
3
THIE_BACSU
A:
[14-223]
-----------
M
K
E
L
L
-
S
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
---
D
A
L
------
T
G
E
A
R
I
K
F
A
E
K
A
Q
A
A
C
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
-
G
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
-
D
T
--
R
A
V
Q
G
V
-
S
L
I
E
A
V
R
R
Q
-----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
Q
T
Y
----
3
PsiBlast_PDB
69.24
32%
-111
- C2 -
2TPS
3
THIE_BACSU
A:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
4
PsiBlast_PDB
69.16
32%
-110
- C2 -
1G4T
3
THIE_BACSU
A:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
57
HHSearch
69.14
28%
-116
- C2 -
3NL6
1
?
A:
[6-247]
-----------
E
Q
F
D
Y
-
S
L
Y
L
V
T
-
S
G
M
--
I
P
EG
K
T
L
Y
G
Q
V
E
A
G
L
Q
N
G
V
T
L
V
Q
I
R
E
K
D
A
---
D
T
K
---------
F
F
I
E
E
A
L
Q
I
K
E
L
C
H
A
H
N
V
P
L
I
I
N
D
R
I
D
V
A
M
A
I
G
A
D
G
I
H
V
G
Q
D
D
M
P
I
P
M
I
R
K
L
V
G
P
D
M
V
I
G
W
S
V
G
F
P
---
E
E
V
D
E
L
S
K
M
G
P
V
D
Y
I
G
V
G
T
L
F
P
T
L
T
-------KK
A
P
-
M
G
T
-
A
G
A
I
R
V
L
D
A
L
E
R
N
N
A
H
W
C
R
T
---
V
G
I
G
G
L
H
P
D
N
I
E
R
V
L
----
Y
Q
CVSSNGK
R
S
L
D
G
----
I
C
V
V
S
D
I
I
A
S
L
D
A
A
K
S
T
K
I
L
R
G
L
I
D
K
T
D
---
16
PsiBlast_PDB
68.95
31%
-108
- C2 -
3NM3
3
?
A:
[12-251]
------------------
L
Y
L
V
T
D
S
G
M
IP
E
G
--
K
T
L
Y
G
Q
V
E
A
G
L
Q
N
G
V
T
L
V
Q
I
R
E
K
D
A
-----
D
T
K
F
F
I
E
E
A
L
Q
I
K
E
L
C
-------
H
A
H
N
V
P
L
I
I
N
D
R
I
D
V
A
M
A
I
G
A
D
G
I
H
V
G
Q
D
D
M
P
I
P
M
I
R
K
L
V
G
P
D
M
V
I
G
W
S
V
G
F
P
E
E
V
D
E
L
S
K
M
G
P
D
M
-
V
D
Y
I
G
V
G
T
L
F
P
T
L
T
K
KN
P
--------
M
G
T
A
G
A
I
R
V
L
D
A
L
E
----
R
N
N
A
H
W
C
R
T
V
G
I
G
G
L
H
P
D
N
I
E
R
V
L
Y
QCV
S
--------
S
N
G
K
R
SLD
G
I
C
V
V
S
D
I
I
A
S
L
D
A
A
K
S
T
K
I
L
R
----------
8
PsiBlast_PDB
68.84
31%
-110
- C2 -
1G4S
3
THIE_BACSU
A:
[19-219]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
12
PsiBlast_PDB
68.66
31%
-111
- C2 -
1G67
4
THIE_BACSU
A:
[18-218]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
17
PsiBlast_PDB
68.64
31%
-107
- C2 -
3NM1
4
?
A:
[12-254]
------------------
L
Y
L
V
T
D
S
G
M
IP
E
G
--
K
T
L
Y
G
Q
V
E
A
G
L
Q
N
G
V
T
L
V
Q
I
R
E
K
D
A
-----
D
T
K
F
F
I
E
E
A
L
Q
I
K
E
L
C
-------
H
A
H
N
V
P
L
I
I
N
D
R
I
D
V
A
M
A
I
G
A
D
G
I
H
V
G
Q
D
D
M
P
I
P
M
I
R
K
L
V
G
--
M
V
I
G
W
S
V
G
F
P
E
E
V
D
E
L
S
K
M
G
P
---
V
D
Y
I
G
V
G
T
L
F
P
T
L
T
K
KN
P
-
K
K
--
A
P
-
M
G
T
A
G
A
I
R
V
L
D
A
L
E
----
R
N
N
A
H
W
C
R
T
V
G
I
G
G
L
H
P
D
N
I
E
R
V
L
Y
QCV
S
--------
S
N
G
K
R
SLD
G
I
C
V
V
S
D
I
I
A
S
L
D
A
A
K
S
T
K
I
L
R
----------
23
PsiBlast_CBE
68.58
32%
-110
- C2 -
2TPS
3
THIE_BACSU
B:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
10
PsiBlast_PDB
68.58
31%
-108
- C2 -
1G6C
4
THIE_BACSU
A:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
5
PsiBlast_PDB
68.56
32%
-109
- C2 -
3O15
3
THIE_BACSU
A:
[28-228]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
40
PsiBlast_CBE
68.43
31%
-112
- C2 -
3NL3
3
?
C:
[12-254]
------------------
L
Y
L
V
T
D
S
G
M
IP
E
G
--
K
T
L
Y
G
Q
V
E
A
G
L
Q
N
G
V
T
L
V
Q
I
R
E
K
D
A
-----
D
T
K
F
F
I
E
E
A
L
Q
I
K
E
L
C
-------
H
A
H
N
V
P
L
I
I
N
D
R
I
D
V
A
M
A
I
G
A
D
G
I
H
V
G
Q
D
D
M
P
I
P
M
I
R
K
L
V
G
P
D
M
V
I
G
W
S
V
G
F
P
E
E
V
D
E
L
S
K
M
G
P
D
M
-
V
D
Y
I
G
V
G
T
L
F
P
T
L
T
K
KN
P
---------
G
T
A
G
A
I
R
V
L
D
A
L
E
----
R
N
N
A
H
W
C
R
T
V
G
I
G
G
L
H
P
D
N
I
E
R
V
L
YQCV
S
--------
S
N
G
K
R
SL
D
G
I
C
V
V
S
D
I
I
A
S
L
D
A
A
K
S
T
K
I
L
R
----------
25
PsiBlast_CBE
68.38
31%
-110
- C2 -
1G4S
3
THIE_BACSU
B:
[19-219]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
24
PsiBlast_CBE
68.19
32%
-111
- C2 -
1G4T
3
THIE_BACSU
B:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
S
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
29
PsiBlast_CBE
68.12
31%
-112
- C2 -
1G67
4
THIE_BACSU
B:
[18-218]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
27
PsiBlast_CBE
68.02
31%
-113
- C2 -
1G6C
4
THIE_BACSU
B:
[20-220]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
11
PsiBlast_PDB
67.97
31%
-107
- C2 -
1G69
4
THIE_BACSU
A:
[21-221]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------
28
PsiBlast_CBE
66.62
31%
-106
- C2 -
1G69
4
THIE_BACSU
B:
[21-221]
------------------
V
Y
F
I
M
G
S
N
N
--
T
K
--
A
D
P
V
T
V
V
Q
K
A
L
K
G
G
A
T
L
Y
Q
F
R
E
K
G
G
DAL
T
G
E
A
R
I
K
F
--
A
E
K
A
Q
A
A
C
-------
R
E
A
G
V
P
F
I
V
N
D
D
V
E
L
A
L
N
L
K
A
D
G
I
H
I
G
Q
E
D
A
N
A
K
E
V
R
A
A
I
G
-
D
M
I
L
G
V
A
A
H
T
M
---
S
E
V
K
Q
A
E
E
D
G
-
A
D
Y
V
G
L
G
P
I
Y
P
T
E
T
K
--
K
D
T
R
--
A
V
-
Q
G
V
-
S
L
I
E
-
A
V
R
R
Q
----
G
I
S
I
P
I
---
V
G
I
G
G
I
T
I
D
N
A
A
P
V
I
----
Q
--------
A
G
A
D
G
----
V
S
M
I
S
A
I
S
Q
A
E
D
P
E
S
A
A
R
K
F
R
E
E
I
-------