@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1256c: (2016-04-30 )
MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70.......--.80......-----..90........100.......110.......120.......130.--...-...140.......150.......160.......170......-.180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.---.--.--.....300.-......310.......320.......330.......340.......350.......360.......370.....--..--380-.--..--.....-390.......400...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSVMSH
E
F
Q
L
A
TAETWPN
P
W
P
M
Y
R
A
LRDHDPVHHVVPPQRPEY
D
Y
Y
V
L
SRHA
D
V
W
S
A
ARDHQTFSSAQ
G
L
T
V
NYG
E
L
--
E
M
I
GLHDTP-----PMVMQDPPV
H
T
E
F
R
K
L
V
SRGFTPRQVETV
E
P
T
V
R
K
F
V
V
E
R
L
E
K
L
R
A--NG
G
-
G
D
I
V
T
E
L
F
KP
L
P
S
M
V
V
A
H
YLGVP
E
E
D
WTQFD
G
W
T
Q
A
I
VAANA-VDGATT
G
A
L
D
A
V
G
S
M
M
A
Y
F
T
G
L
I
E
R
RRTEP
A
D
D
A
I
S
H
L
V
A
AGVGADGDTA
G
T
L
S
I
L
A
F
T
F
T
M
V
TGGND
T
V
T
G
MLGGSMPLLHRRPDQ
R
R
L
LLDDPEG
I
P
D
A
V
E
E
L
L
R
LTS
P
V
-
Q
G
---
L
--
A
--RTTT
R
D
V
T
I-GDTTIPAG
R
R
V
L
L
L
Y
GSANR
D
E
RQYGPDAAEL
D
V
T
RCPRN
I
L
TFSHG
A
H
H
C
L
G
A
A
A
A
R
M
Q
C
R
V
A
L
T
E
L
L
A
RCPD--FE--VA--E--
S
R
--
I
V
WSG-GS
Y
V
RRPLSV
P
F
R
VTS
1
PsiBlast_PDB
98.98
100%
-104
- C4 -
2UVN
8
CP130_MYCTU
A:
[13-412]
-----
S
H
E
F
Q
L
A
T
A
E
T
W
P
N
P
W
P
M
Y
R
A
L
R
D
H
D
P
V
H
H
V
V
P
P
Q
R
P
E
Y
D
Y
Y
V
L
S
R
H
A
D
V
W
S
A
A
R
D
H
Q
T
F
S
S
A
Q
G
L
T
V
N
Y
G
E
L
--
E
M
I
G
L
H
D
T
P
-----
P
M
V
M
Q
D
P
P
V
H
T
E
F
R
K
L
V
S
R
G
F
T
P
R
Q
V
E
T
V
E
P
T
V
R
K
F
V
V
E
R
L
E
K
L
R
A
--
N
G
G
-
G
D
I
V
T
E
L
F
K
P
L
P
S
M
V
V
A
H
Y
L
G
V
P
E
E
D
W
T
Q
F
D
G
W
T
Q
A
I
V
A
A
N
----
G
A
T
T
G
A
L
D
A
V
G
S
M
M
A
Y
F
T
G
L
I
E
R
R
R
T
E
P
A
D
D
A
I
S
H
L
V
A
A
G
V
G
A
D
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
M
V
T
G
G
N
D
T
V
T
G
M
L
G
G
S
M
P
L
L
H
R
R
P
D
Q
R
R
L
L
L
D
D
P
E
G
I
P
D
A
V
E
E
L
L
R
L
T
S
P
V
-
Q
G
---
L
--
A
--
R
T
T
T
R
D
V
T
I
-
G
D
T
T
I
P
A
G
R
R
V
L
L
L
Y
G
S
A
N
R
D
E
R
Q
Y
G
P
D
A
A
E
L
D
V
T
R
C
P
R
N
I
L
T
F
S
H
G
A
H
H
C
L
G
A
A
A
A
R
M
Q
C
R
V
A
L
T
E
L
L
A
R
C
P
D
--
F
E
--
V
A
--
E
--
S
R
--
I
V
W
S
G
-
G
S
Y
V
R
R
P
L
S
V
P
F
R
V
T
S
21
PsiBlast_CBE
98.07
100%
-111
- C4 -
2WH8
3
CP130_MYCTU
C:
[12-409]
-----
S
H
E
F
Q
L
A
T
A
E
T
W
P
N
P
W
P
M
Y
R
A
L
R
D
H
D
P
V
H
H
V
V
P
P
Q
R
P
E
Y
D
Y
Y
V
L
S
R
H
A
D
V
W
S
A
A
R
D
H
Q
T
F
S
S
A
Q
G
L
T
V
N
Y
G
E
L
--
E
M
I
G
L
H
D
T
P
-----
P
M
V
M
Q
D
P
P
V
H
T
E
F
R
K
L
V
S
R
G
F
T
P
R
Q
V
E
T
V
E
P
T
V
R
K
F
V
V
E
R
L
E
K
L
R
A
--
N
G
G
-
G
D
I
V
T
E
L
F
K
P
L
P
S
M
V
V
A
H
Y
L
G
V
P
E
E
D
W
T
Q
F
D
G
W
T
Q
A
I
V
A
A
---------
G
A
L
D
A
V
G
S
M
M
A
Y
F
T
G
L
I
E
R
R
R
T
E
P
A
D
D
A
I
S
H
L
V
A
A
G
V
G
--
G
D
T
A
G
T
L
S
I
L
A
F
T
F
T
M
V
T
G
G
N
D
T
V
T
G
M
L
G
G
S
M
P
L
L
H
R
R
P
D
Q
R
R
L
L
L
D
D
P
E
G
I
P
D
A
V
E
E
L
L
R
L
T
S
P
V
-
Q
G
---
L
--
A
--
R
T
T
T
R
D
V
T
I
-
G
D
T
T
I
P
A
G
R
R
V
L
L
L
Y
G
S
A
N
R
D
E
R
Q
Y
G
P
D
A
A
E
L
D
V
T
R
C
P
R
N
I
L
T
F
S
H
G
A
H
H
C
L
G
A
A
A
A
R
M
Q
C
R
V
A
L
T
E
L
L
A
R
C
P
D
--
F
E
--
V
A
--
E
--
S
R
--
I
V
W
S
G
-
G
S
Y
V
R
R
P
L
S
V
P
F
R
V
--
114
HHSearch
75.41
31%
-90
- C4 -
4MM0
1
?
A:
[11-399]
-------
H
P
Y
P
F
D
R
A
V
P
T
A
I
P
P
L
Y
E
E
L
R
E
T
E
R
V
A
A
I
T
M
A
--
T
G
D
P
G
F
L
V
T
R
Y
E
D
V
R
F
V
L
S
D
P
R
-
F
S
V
R
Q
D
-
L
P
G
A
-
P
----
R
L
T
E
M
T
F
E
-----
S
V
M
T
T
D
P
P
V
H
T
R
L
R
R
L
L
S
R
D
F
T
A
R
R
I
E
R
M
R
P
R
L
E
E
I
A
E
G
L
L
D
E
M
E
K
K
-
G
A
P
-
A
D
I
V
E
S
L
A
V
P
F
P
I
T
V
I
C
E
L
L
G
V
P
M
V
D
V
A
R
F
R
G
W
A
D
T
M
V
S
L
T
G
--
Y
S
M
-
E
D
W
T
A
A
R
D
A
L
E
S
Y
L
D
G
L
V
A
A
K
R
E
N
P
G
S
D
L
L
S
A
L
V
A
T
A
A
--
E
D
N
E
L
T
D
H
D
V
R
S
L
S
L
I
L
L
L
A
G
Y
E
P
A
S
N
Q
L
G
S
S
V
L
T
L
L
R
F
P
D
R
L
A
E
L
R
R
D
P
G
L
L
P
S
A
V
E
E
L
M
R
Y
A
P
A
G
-
D
G
A
--
L
--
F
--
R
V
T
L
E
D
V
T
I
-
G
D
T
H
I
P
A
N
S
A
V
L
A
S
T
Q
A
A
N
W
D
P
R
R
F
-
D
D
P
T
G
L
R
L
D
R
P
D
N
Q
H
T
A
L
G
H
G
I
H
F
C
L
G
A
A
L
A
R
V
E
L
Q
V
A
I
G
A
L
L
R
R
F
-
P
R-
L
A
--
L
A
--
T
--
D
E
SG
L
R
W
S
S
P
G
S
M
L
S
G
F
A
E
I
P
V
T
W
--
127
HHSearch
75.37
32%
-99
- C4 -
4WPZ
3
?
A:
[6-397]
----------
F
P
D
P
P
S
V
-
E
L
P
P
E
L
A
E
I
R
D
G
Q
S
V
V
E
V
K
F
P
--
D
G
I
S
G
W
M
V
T
K
H
A
D
V
R
K
V
L
V
D
S
-
R
F
S
S
K
V
-----------
T
E
T
G
K
L
M
N
E
-----
S
L
V
G
M
D
A
P
E
H
T
R
L
R
K
L
V
T
K
A
F
T
A
R
R
V
E
T
L
R
P
R
I
T
E
L
V
G
Q
L
L
D
E
L
E
T
L-
P
R
P
-
V
D
L
V
K
N
F
S
V
P
L
P
V
R
V
I
C
E
L
L
G
V
P
A
G
D
Q
D
T
F
H
A
W
S
N
A
L
L
G
-
D
W
--
Q
Q
V
-
V
E
K
E
A
A
T
V
S
L
V
N
Y
F
G
E
L
I
A
V
K
R
E
N
P
A
D
D
L
I
S
E
L
I
A
I
S
D
--
G
D
S
T
L
T
E
R
E
I
I
A
L
S
I
G
I
L
S
A
G
H
E
T
T
A
N
Q
I
S
M
F
L
V
T
L
L
H
N
P
E
E
L
D
K
L
R
D
N
R
E
A
I
P
K
A
V
D
E
L
L
R
F
V
P
L
T
-
T
T
GGI
I
--
P
--
R
L
T
T
A
E
V
E
L
S
G
G
Q
V
L
P
A
G
A
V
V
L
P
A
V
A
T
A
N
R
D
P
E
V
F
-
E
D
G
E
R
L
N
V
T
R
E
N
N
P
H
L
A
F
G
A
G
I
H
H
C
L
G
A
Q
L
A
R
I
E
L
Q
E
A
L
G
A
I
L
D
R
M
P
Q
--
V
R
--
L
A
--
V
--
P
E
SE
L
R
L
K
S
-
A
S
I
I
R
G
L
E
S
L
P
I
T
W
--
41
PsiBlast_CBE
74.56
35%
-97
- C4 -
2Y5Z
7
MYCG_MICGR
B:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
97
PsiBlast_CBE
74.30
33%
-98
- C4 -
4Z5P
2
?
B:
[24-398]
---------------------
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
Y
G
G
E
G
--
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
-
F
S
R
A
Q
-------------
I
G
-
E
D
T
P
RTTPD
T
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
E
R
--
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
S
T
T
A
-
Y
--
S
K
E
E
A
V
S
A
D
A
S
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
R
--
D
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
L
G
-
N
G
---
V
GN
A
--
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
-
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
--
L
R
--
L
A
VP
A
--
D
Q
--
V
E
W
K
T
-
G
G
L
F
R
G
P
Q
R
L
P
I
----
15
PsiBlast_PDB
74.24
35%
-98
- C4 -
2YCA
6
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
13
PsiBlast_PDB
74.22
35%
-95
- C4 -
2Y98
7
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
11
PsiBlast_PDB
74.11
35%
-94
- C4 -
2Y5N
9
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
36
PsiBlast_CBE
74.08
35%
-94
- C4 -
4AW3
8
MYCG_MICGR
B:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
VP
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
9
PsiBlast_PDB
74.06
35%
-94
- C4 -
4AW3
8
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
V
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
2
PsiBlast_PDB
74.06
35%
-94
- C4 -
3A4G
2
CPVDH_PSEAH
A:
[9-389]
------
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
D
G
P
---
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
S
K
D
W
R
H
T
L
P
E
D
Q
R
--
A
D
M
P
A
T
P
T
P
-----
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
S
P
-
A
D
D
K
N
A
----
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
-
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
---
P
--
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
-
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
--
L
A
--
L
A
--
V
GL
D
E
--
L
V
Y
R
E
-
S
T
L
V
R
-----------
98
PsiBlast_CBE
74.01
33%
-98
- C4 -
4Z5P
1
?
A:
[24-398]
---------------------
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
Y
G
G
E
G
--
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
-
F
S
R
A
Q
-------------
I
G
-
E
D
T
P
RTTPD
T
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
E
R
--
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
S
T
T
A
-
Y
--
S
K
E
E
A
V
S
A
D
A
S
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
R
--
D
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
V
P
L
G
-
N
G
---
V
G
N
A
--
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
-
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
--
L
R
--
L
A
VP
A
--
D
Q
--
V
E
W
K
T
-
G
G
L
F
R
G
P
Q
R
L
P
I
----
79
PsiBlast_CBE
74.01
31%
-93
* C4 *
4BF4
2
PIKC_STRVZ
D:
[47-424]
------------------
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
E
G
N
E
V
--
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
--
E
A
A
L
N
H
N
--------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
-
P
A
Q
A
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
-
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
---
A
--
T
Y-
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
-
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
LA
L
D
--
V
S
--
P
--
G
E
--
L
V
W
Y
P
-
N
P
M
I
R
G
L
K
A
L
P
I
R
---
10
PsiBlast_PDB
73.89
35%
-96
- C4 -
2Y46
6
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
32
PsiBlast_CBE
73.86
35%
-93
- C4 -
3A4Z
4
CPVDH_PSEAH
C:
[3-389]
L
T
T
T
G
T
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
D
G
P
---
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
D
W
R
H
R
L
P
E
D
Q
R
A
--
D
M
P
A
T
P
-
T
P
-----
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
S
P
-
A
D
D
K
N
A
----
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
-
D
M
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
---
P
--
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
-
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
--
L
A
--
L
A
--
V
GL
D
E
--
L
V
Y
R
R
-
S
T
L
V
R
-----------
3
PsiBlast_PDB
73.86
35%
-92
- C4 -
3A4H
2
CPVDH_PSEAH
A:
[4-389]
-
T
T
T
G
T
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
D
G
P
---
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
S
K
D
W
R
H
T
L
P
E
D
Q
R
--
A
D
M
P
A
T
P
T
P
-----
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
S
P
-
A
D
D
K
N
A
----
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
-
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
A
---
P
--
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
-
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
--
L
A
--
L
A
--
V
GL
D
E
--
L
V
Y
R
E
-
S
T
L
V
R
-----------
40
PsiBlast_CBE
73.84
35%
-95
- C4 -
2Y5Z
6
MYCG_MICGR
C:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
FP
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
37
PsiBlast_CBE
73.67
35%
-94
- C4 -
2YGX
4
MYCG_MICGR
D:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
FP
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
12
PsiBlast_PDB
73.67
35%
-93
- C4 -
2Y5Z
8
MYCG_MICGR
A:
[43-414]
-----------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
Y
G
E
E
A
--
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
-
F
V
R
G
P
S
M
T
R
D
E
P
R
T
RP
E
M
V
----
K
G
-----
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
A
A
--
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
E
-
V
T
A
E
E
M
Q
--
E
A
A
E
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
--
D
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
V
P
L
G
-
V
G
---
T
--
A
F
P
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
-
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
--
I
R
LG
I
P
--
E
--
T
Q
--
L
R
W
S
E
-
G
M
L
L
R
G
P
L
E
L
P
-----
86
PsiBlast_CBE
73.13
31%
-93
- C4 -
3ZPI
13
PIKC_STRVZ
A:
[47-424]
------------------
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
E
G
N
E
V
--
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
S
K
D
W
R
N
S
T
T
P
L
T
E
A
--
E
A
A
L
N
H
N
--------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
-
P
A
Q
A
Q
T
----
A
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
-
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
---
A
--
T
Y
-
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
-
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
LA
L
D
--
V
S
--
P
--
G
E
--
L
V
W
Y
P
-
N
P
M
I
R
G
L
K
A
L
P
I
R
---
117
HHSearch
70.80
30%
-89
- C4 -
3WVS
8
?
A:
[10-401]
----
P
E
S
L
S
Y
P
F
G
P
D
E
G
L
A
L
S
E
S
Y
T
R
A
R
D
T
D
G
L
I
R
V
K
L
P
--
Y
G
E
P
A
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
D
A
-
R
F
S
R
A
L
S
E
E
H
-
D
P
P
R
--
A
R
K
F
N
A
Q
A
K
-----
S
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
K
-
G
E
P
-
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
L
S
T
S
T
L
N
P
E
---
E
G
R
V
K
R
M
E
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
E
A
R
D
--
V
Q
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
L
G
-
S
G
SA-
A
--
P
--
R
Y
A
R
E
D
I
E
V
-
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
-
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
-
P
--
T
L
--
K
V
--
A
--
G
D
--
I
A
W
K
S
-
E
M
M
V
R
G
P
R
S
M
P
V
G
W
--
103
PsiBlast_CBE
67.26
35%
-104
- C4 -
3WVS
7
?
A:
[90-398]
-----------------------------------------------------------------------------------------------
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
--
K
G
E
P
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
L
S
T
S
T
-
L
N
-
P
E
E
G
R
V
K
R
M
-
E
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
E
A
R
D
V
Q
D
K
L
T
E
Q
E
L
--
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
L
G
-
S
G
---
S
--
A
A
P
R
Y
A
R
E
D
I
E
V
-
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
-
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
P
T
--
L
K
--
V
A
-----
G
D
--
I
A
W
K
S
-
E
M
M
V
R
G
P
R
S
M
P
-----