@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1473: (2016-05-02 )
MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLSGGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERKAAALRAQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRTPLVANGLGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGPQRVVLLPDGTEDYWSDEYRDLIELA
Atome Classification :
(37 SA)
--------------------------------------------------------------------.........10.-.-------......20.....------...30.........40........50....--------..--..60-..-.-----------.---..--.----..70......-..80...--.....90........100-.........110---..-.....---.-120.......130.......140.......150.......160.......170.......180.......190.......200---........210..---..---.---..220..---.---....230.......240.....---..250..-.....260.......270..---.....280.......290.......300.......310.......320......---.330.......340....--..--..350.......360.......370.......-380.......390..--------------..-----...------------.------------400....-----..-.410-.......-.420.----.----------------------------------------------------------------------.-------------------------------------.----..---.430..-------..-....440--..---...-..--------------..450---.----------.......460.......470.......480.......---490---.......----.500-.----........510........-520.....-..530..-.-...-.540-----------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------MITA
T
D
L
E
V
RAG-
A
-------
R
I
L
LAPDGPD
L
R
V------QPG
D
-
R
I
G
L
VGRNGAGK
T
T
T
L
R
I
L
AGEVEP--------YA--GSV--TR-A-----------G---EI--G----YLPQDPKVG
D
-
L
D
V
L
A
RD--RVLSARG
L
D
V
L
L
T
D
L
E
---
K
Q
Q
A
L
M
A
E
VAD----
E
D
-
E
R
D
R
A
---
I
-
R
R
Y
G
Q
L
E
E
R
F
V
ALGGYGAES
E
A
G
R
I
C
A
SLGL
P
E
R
V
L
T
Q
R
L
R
T
LSGGQ
R
R
R
V
E
L
A
R
I
L
F
AASESGAGN
S
T
T
L
L
LDEPTNHLDA----
D
S
L
G
W
L
R
D
F
L
R
LH---TG---
G
---
L
V
V
I
SH
N
---
V
---
D
L
V
A
D
V
V
N
K
V
W
F
L
D
AVRGQV
D
V
---YNM
G
W
Q
R
-
Y
VDARA
T
D
E
Q
R
R
I
R
E
R
AN
A
E
---
R
K
A
A
A
L
R
A
Q
A
A
KLG
A
K
A
T
K
A
V
A
A
Q
N
M
L
R
R
A
D
R
M
M
A
A
L
D
E
E
R
V
A
D
K
V
ARIKFPTP---AACGRT
P
L
VANG-LGKTY--GS--
L
E
V
F
TG
V
D
L
A
IDRG
S
R
V
V
I
L
GLNGA
G
K
T
T
L
L
R
-
L
L
AGVEQPDTG-VLE--------------PG-----Y
G
L
------------
R
------------
I
G
Y
F
AQE-----HD-TLD--N
D
A
T
V
W
E
-
N
V
R
HA----A----------------------------------------------------------------------P-------------------------------------D----A
G
---
E
Q
-
D
L
R
-------
G
L
-
L
G
A
F
M----FT---GPQ-LE--------------QPAG----T----------LSGGE
K
T
R
L
A
L
A
G
L
V
AST
A
N
V
L
L
LDEPTNNLD
P
A
S
R
E
---
Q
V
----
L
D
A
L
R
SY----R
G
---
A
----
V
V
L
V
THDPGA-AAALGP
Q
R
-
V
V
L
LPDGT-
E
D
Y
W
S
D
E
-
Y
-
R
D
L
-
I
ELA-----------------------------------------------------------------------------------------------------------------------
38
HHSearch
84.78
30%
-84
- C1 -
4FIN
13
ETTA_ECOLI
A:
[5-518]
--------------------------------------------------------------------
V
Y
T
M
H
R
V
G
K
V
V
P
P
K
-------
R
H
I
L
--
K
N
I
S
L
S
F
------
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
--------
I
E
--
G
E
A
--
R
P
-
Q
-----------
P
D
I
-
K
I
--
G
----
Y
L
P
Q
E
P
Q
L
-
N
-
P
E
H
T
V
R
E
--
S
I
E
E
A
---------
V
S
---
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
-
D
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
-------
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
---
T
---
V
V
A
I
T
H
D
---
R
---
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
--
G
E
G
I
P
---
W
E
G
N
Y
S
S
-
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
---
K
S
I
E
K
E
L
E
W
V
R
Q
G
-
T
K
-----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
--
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
---
P
R
L
G
D
K
V
L
E
V
S
N
-
L
R
K
S
Y
--
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
G
Q
E
Q
P
D
S
G
-
T
I
T
--------------
L
G
-----
E
T
V
------------
K
------------
L
A
S
V
D
Q
F
-----
R
D
-
S
M
D
--
N
S
K
T
V
W
E
-
E
V
S
G
G
----
L
----------------------------------------------------------------------
D
-------------------------------------
I
MKIG
N
T
---
E
M
-
P
S
R
-------
A
Y
-
V
G
R
F
N
----
F
K
---
G
V
D
-
Q
G
--------------
K
R
V
G
----
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
---
A
L
----
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
--
I
L
D
Y
Q
D
E
G
------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
80.17
25%
-89
- C- -
2IW3
7
EF3A_YEAST
A:
[440-979]
-------------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
I
L
L
--
N
K
T
Q
L
R
L
------
K
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
----------
D
--
G
F
P
--
T
Q
E
E
-----------
C
---
R
T
--
V
----
Y
V
E
H
D
I
D
G
T
H
-
S
D
T
S
V
L
D
--
F
V
F
E
S
---------
G
-----------------------------------------------
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
-------
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
N
V
A
W
L
V
N
Y
L
N
T
C
---
G
I
---
T
---
S
I
T
I
S
H
D
---
S
---
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
--
L
K
L
R
K
---
Y
K
G
N
F
T
E
-
F
V
K
K
C
P
A
A
K
-----
A
----------
Y
E
E
L
S
---
N
--------------
T
----
D
L
E
F
K
---
F
P
E
----
P
G
Y
--
L
E
G
V
---
K
T
K
Q
K
A
I
V
K
V
T
N
-
M
E
F
Q
Y
--
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
G
E
L
L
P
T
S
G
-
E
V
Y
--------------
T
H
-----
E
N
C
------------
R
------------
I
A
Y
I
K
Q
H
-----
A
F
A
H
I
E
SH
L
D
K
T
P
S
E
-
Y
I
Q
W
R
----
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFR
P
----
L
T
---
R
K
-
E
I
E
-------
E
H
-
C
S
M
L
G
----
L
D
---
P
E
I
V
S
H
--------------
S
R
I
R
----
G
----------
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
---
A
L
----
S
K
A
L
K
E
F
----
E
G
---
G
----
V
I
I
I
T
H
S
A
E
F
-
T
K
N
L
T
E
E
--
V
W
A
V
K
D
G
R
M
T
P
S
--------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.68
32%
-75
- C1 -
4FIN
12
ETTA_ECOLI
A:
[27-500]
---------------------------------------------------------------------------------------------------
L
S
F
------
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
--------
I
E
--
G
E
A
--
R
P
-
Q
-----------
P
---
D
I
K
I
G
----
Y
L
P
Q
E
P
Q
L
-
N
-
P
E
H
T
V
R
E
--
S
I
E
E
A
--
V
S
E
V
V
N
A
L
K
---
R
L
D
E
V
Y
A
L
Y
A
D
----
P
D
A
D
F
D
K
L
---
A
-
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
-------
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
---
T
---
V
V
A
I
T
H
D
---
R
---
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
D
R
G
E
-------
G
I
P
W
E
G
-
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
-----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
--
N
E
T
N
E
L
F
I
P
P
G
---
P
R
L
G
D
K
V
L
E
V
S
N
-
L
R
K
S
Y
--
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
G
Q
E
Q
P
D
S
G
-
T
I
T
--------------
L
G
-----
E
T
V
------------
K
------------
L
A
S
V
D
Q
F
-----
R
D
-
S
M
D
--
N
S
K
T
V
W
E
-
E
V
S
G
G
LDIM
K
----------------------------------------------------------------------
I
-------------------------------------
G
----
N
T
---
E
M
-
P
S
R
-------
A
Y
-
V
G
R
F
N
----
F
K
---
G
V
D
-
Q
G
--------------
K
R
V
G
----
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
---
A
L
----
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.22
32%
-57
- C1 -
3J5S
-
ETTA_ECOLI
D:
[27-500]
---------------------------------------------------------------------------------------------------
L
S
F
------
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
--------
I
E
--
G
E
A
--
R
P
-
Q
-----------
P
---
D
I
KI
G
----
Y
L
P
Q
E
P
Q
L
-
N
-
P
E
H
T
V
R
E
--
S
I
E
E
A
--
V
S
E
V
V
N
A
L
K
---
R
L
D
E
V
Y
A
L
Y
A
D
----
P
D
A
D
F
D
K
L
---
A
-
A
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
-------
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
S
V
A
W
L
E
R
F
L
H
D
F
---
E
G
---
T
---
V
V
A
I
T
H
D
---
R
---
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
D
R
G
E
-------
G
I
P
W
E
G
-
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
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A
S
Q
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AAR
R
K
S
I
E
K
E
L
E
W
V
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G
T
K
G
R
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S
-
K
G
K
A
R
L
A
R
F
E
E
L
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S
T
E
Y
Q
K
R
--
N
E
T
N
E
L
F
I
P
P
G
---
P
R
L
G
D
K
V
L
E
V
S
N
-
L
R
K
S
Y
--
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--
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L
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L
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G
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G
P
N
G
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G
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T
L
F
R
-
M
I
S
G
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E
Q
P
D
S
G
-
T
I
T
--------------
L
G
-----
E
T
V
------------
K
------------
L
A
S
V
D
Q
F
-----
R
D
-
S
M
D
--
N
S
K
T
V
W
E
-
E
V
S
G
G
LDIM
K
----------------------------------------------------------------------
I
-------------------------------------
G
----
N
T
---
E
M
-
P
S
R
-------
A
Y
-
V
G
R
F
N
----
F
K
---
G
V
D
-
Q
G
--------------
K
R
V
G
----
E
----------
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
---
A
L
----
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
66.95
22%
-57
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
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K
T
GKLC
I
E
V
T
PTSK
I
A
F
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EILCIGCG
I
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V
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CPFD
A
I
Q
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N
L
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T
N
L
E
-
A
-------
H
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L
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G
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K
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K
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L
A
G
K
Q
K
P
--------
N
L
--
G
R
F
--
D
D
-
P
-----------
P
---
E
W
--
Q
----
E
I
I
K
Y
-----------------
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M
L
---
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D
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A
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N
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---
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-------
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---
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---
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---
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---
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---
V
T
L
--------------
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---
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----------------
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-----
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---
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Q
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----
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--
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G
E
---
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
-
Q
D
I
--------------
P
K
-------
L
------------
N
------------
V
S
M
K
P
Q
K
-----
I
A
-
P
K
F
--
P
G
T
V
R
Q
L
-
F
F
K
K
I
----
R
----------------------------------------------------------------------
G
-------------------------------------
Q
----
F
L
---
N
P
-
Q
F
Q
-------
T
D
-
V
V
K
P
L
----
R
I
---
D
D
I
-
I
D
--------------
Q
E
V
Q
----
H
----------
L
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G
G
E
L
Q
R
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A
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L
D
S
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R
I
---
I
C
----
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K
V
I
R
R
F
----
I
L
---
H
N
K
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A
F
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E
H
D
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A
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NVTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI------------------------------------------------------------------------
8
PsiBlast_PDB
64.95
26%
-70
- C1 -
1YQT
4
?
A:
[44-461]
-----------------------------------------------------------------------------------------------------
V
------
K
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
NLCGDNDS
W
D
--
G
V
I
R
A
F
R
-
G
-----------
N
---
E
L
--
Q
----
N
Y
F
E
K
L
K
N
G
E
-
I
R
-------
P
V
V
K
P
Q
Y
V
D
L
I
P
K
A
V
K
---
G
K
V
I
E
L
L
K
K
A
D
----
E
T
--------------
G
K
L
E
E
----------------
V
V
K
A
L
E
L
-
E
N
V
L
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H
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S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
-------
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
---
Q
R
L
N
A
A
R
A
I
R
R
L
S
---
E
E
---
G
K
S
-
V
L
V
V
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---
L
A
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L
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------
G
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P
G
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---
Y
G
I
F
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Q
---------------------------------------
P
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G
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N
-
G
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N
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F
L
R
------
G
Y
L
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R
F
R
P
Y
E
I
K
F
T
K
T
GER
V
E
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R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
--
G
S
F
R
L
E
V
E
P
G
---
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
-
K
I
E
---------------------
W
D
L
------------
T
------------
V
A
Y
K
P
Q
------
Y
I
-
K
A
D
--
Y
E
G
T
V
Y
E
-
L
L
--
S
----
K
----------------------------------------------------------------------
I
-------------------------------------
D
----
A
S
---
K
L
-
N
S
N
-------------------
F
Y
---
K
T
E
-
L
L
--------------
K
P
L
G
----
I
IDLYDREVNE
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
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Y
L
L
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S
A
Y
L
D
V
E
Q
R
L
---
A
V
----
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
62.61
21%
-68
- C1 -
3OZX
5
?
A:
[4-463]
-------------------------------------------------------------------------
E
V
I
H
R
Y
K
V
N
-------
G
F
K
L
--
F
G
L
P
T
-
P
------
K
N
N
T
-
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
--------
N
F
--
G
D
P
--
N
S
-
K
VG
K
D
E
V
L
K
R
F
R
G
K--
E
I
--
Y
----
N
Y
F
K
E
L
Y
--
S
-
N
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L
K
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H
--
K
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Q
Y
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E
Y
-------
A
S
---
K
F
L
K
---------------------------
G
T
V
N
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L
---
T
K
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D
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G
K
K
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L
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N
-
L
W
N
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D
A
N
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G
G
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L
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A
A
S
L
L
R
E
-------
A
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S
Y
L
D
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----
R
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R
M
N
M
A
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A
I
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L
L
K-
N
K
---
Y
---
V
I
V
V
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---
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L
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---
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---
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A
A
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A
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-----
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---------------------
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---
F
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T
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S
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T
--------------
P
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-----
K
-
Q
------------
I
------------
L
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-----
I
--
F
P
N
--
Y
D
G
T
V
Q
Q
-
Y
L
E
N
A
----
S
----------------------------------------------------------------------
K
-------------------------------------
D
ALS-
T
S
---
S
W
-
F
F
E
-------
E
V
-
T
K
R
L
N
----
L
H
---
R
-
L
-
L
E
--------------
S
N
V
N
----
D
----------
L
S
G
G
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L
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K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
---
I
V
----
A
K
A
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K
R
V
T
R
E
R
K
A
---
V
----
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F
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I
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H
D
Y
I
A
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--
I
I
V
F
K
G
E
P
------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
61.66
24%
-63
- C1 -
1YQT
4
?
A:
[25-479]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
-
V
N------
A
F
V
L
--
Y
R
L
P
-
V
V
------
K
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G
M
-
V
V
G
I
V
G
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N
G
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G
K
S
T
A
V
K
I
L
A
G
Q
L
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P
--------
N
L
CG
D
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--
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D
-----------
G
---
V
I
--
R
A
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N
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K
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---------
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---
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L
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P
---
K
--------------------
A
V
K
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---
L
L
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K
A
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K
L
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A
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A
A
L
L
R
N
-------
A
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Y
L
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---
S
---
V
L
V
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---
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I
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G
--------
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G
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Q
P
K
G
T
R
N
------------------
G
I
N
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L
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G
Y
L
K
D
------
E
N
V
R
---
F
R
P
Y
E
I
K
--
F
T
K
-
T
--
G
E
R
-----
V
---
E
I
E
R
E
T
L
V
T
Y
P
R
-
L
V
K
D
Y
--
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S
---
F
R
L
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P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
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K
T
T
F
V
K
-
M
L
A
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V
E
E
P
T
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G
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K
I
E
--------------
W
D
-----
L
--------------
T
------------
V
A
Y
K
P
Q
Y
-----
I
--
K
A
D
--
Y
E
G
T
V
Y
E
-
L
L
S
K
I
----
D
----------------------------------------------------------------------
A
-------------------------------------
S
K
L
--
N
S
---
N
F
-
Y
K
T
-------
E
L
-
L
K
P
L
G
----
I
I
---
D
-
L
-
Y
D
--------------
R
E
V
N
----
E
----------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
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L
---
A
V
----
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
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V
L
M
-
I
D
Y
V
S
D
R
--
L
M
V
F
E
G
E
P
------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.29
25%
-57
- C1 -
3BK7
2
?
A:
[114-531]
-----------------------------------------------------------------------------------------------------
V
------
K
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
---------------------------------------------
N
L
C
E
D
N
D
S
W
D
--
N
V
I
R
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F
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R
G
N
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V
K
P
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Y
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------
D
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L
L
P
K
A
---
V
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K
--
G
K
V
R
E
L
L
K
K
V
D
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G
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F
E
E
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V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
-------
F
Y
F
F
D
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P
S
S
Y
L
D
I
R
---
Q
R
L
K
V
A
R
V
I
R
R
L
A
---
N
E
---
G
K
A
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V
L
V
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D
L
A
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L
---
D
Y
L
S
D
V
I
H
V
V
Y
------
G
E
P
G
V
---
Y
G
-------
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
---
L
K
D
E
N
V
R
F
R
P
Y
E
I
---------------
R
F
T
K
L
S
E
R
V
D
V
E
R
----
E
T
L
V
E
Y
P
R
-----------------
L
V
K
D
Y
--
G
S
F
K
L
E
V
E
P
G
---
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
-
K
V
E
---------------------
W
D
L
------------
T
------------
V
A
Y
K
P
Q
------
Y
I
-
K
A
E
--
Y
E
G
T
V
Y
E
-
L
L
--------------------------------------------------------------------------------------------------------------------------
S
---
K
I
-
D
S
S
-------
K
L
-
N
S
N
F
Y
----
K
T
-----
E
-
L
L
--------------
K
P
L
G
----
I
IDLYDRNVED
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
---
A
V
----
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
60.66
23%
-64
- C1 -
3J16
2
RLI1_YEAST
B:
[82-543]
-------------------------------------------------------------------------
H
V
T
H
R
Y
S
-
A
N------
S
F
K
L
--
H
R
L
-
P
T
P
------
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
--------
N
L
--
G
R
F
--
D
D
-
P
-----------
P
E
W
Q
E
I
--
I
----
K
Y
F
R
G
S
E
L
Q
N
Y
F
T
K
M
L
E
D
--
D
I
K
A
I
---------
I
K
---
P
-
Q
Y
V
D
N
I
P
R
A
----
I
K
-----------
G
P
V
Q
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
-------
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
---
Y
---
V
I
C
V
E
H
D
---
L
---
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
--
V
P
S
V
----
Y
-
G
V
V
T
L
----
P
A
S
V
R
E
---------------
G
I
---
N
I
F
L
D
G
H
I
P
A
----
E
N
L
R
F
R
---
T
E
A
L
Q
-----
F
R
I
A
D
-
A
T
---
E
D
L
Q
---
N
D
S
A
S
R
A
F
S
Y
P
S
-
L
K
K
T
Q
--
G
---
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
-
Q
D
I
--------------
P
-------
K
L
------------
N
------------
V
S
M
K
P
Q
K
-----
I
A
--
P
K
--
F
P
G
T
V
R
Q
-
L
F
F
K
K
----
I
----------------------------------------------------------------------
R
-------------------------------------
G
QF--
L
N
---
P
Q
-
F
Q
T
-------
D
V
-
V
K
P
L
R
----
I
D
---
D
-
I
-
I
D
--------------
Q
E
V
Q
----
H
----------
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
---
I
C
----
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
--
V
I
V
F
E
G
--------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
59.76
22%
-67
- C1 -
3BK7
4
?
A:
[84-547]
---------------------------------------------------------------------
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
N
A
F
--
V
L
Y
R
L
P
I
V
-----
K
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
--------
N
L
--
C
E
D
--
N
D
-
S
-----------
W
D
--
N
V
--
I
----
R
A
F
R
G
N
E
L
-
Q
-
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
-------
P
Q
---
Y
V
D
L
L
P
K
---------------------
A
V
K
G
K
V
R
E
L
L
---
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
-------
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
---
A
---
V
L
V
V
E
H
D
---
L
---
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
--
E
P
G
--------
V
Y
G
I
-
F
S
K
P
K
G
T
R
N
------------------
G
I
N
E
F
L
Q
G
Y
L
K
D
------
E
N
V
R
F
R
P
Y
----
E
I
--
R
F
T
-
K
---
L
S
---
E
R
V
---
D
V
E
R
E
T
L
V
E
Y
P
R
-
L
V
K
D
Y
--
G
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
-
K
V
E
--------------
W
D
-------
L
------------
T
------------
V
A
Y
K
P
Q
Y
-----
I
K
--
A
E
--
Y
E
G
T
V
Y
E
-
L
L
S
K
I
----
D
----------------------------------------------------------------------
S
-------------------------------------
S
K
L
--
N
S
---
N
F
-
Y
K
T
-------
E
L
-
L
K
P
L
G
----
I
I
---
D
-
L
-
Y
D
--------------
R
N
V
E
----
D
----------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
---
A
V
----
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
--
L
I
V
F
E
G
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.20
23%
-44
- C1 -
4CRM
3
RLI1_YEAST
P:
[101-541]
------------------------------------------------------------------------------------------------------------
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
------------------------------------
N
L
--
G
----
R
F
D
D
P
P
E
W
Q
E
-
I
I
K
Y
F
R
G
--
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
AII
K
P
Q
Y
V
-----------
D
-
N
I
P
R
A
---
I
-
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
-
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
-------
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
KQRL
N
A
A
Q
I
I
R
S
L
L
A
-
P
---
T
K
---
Y
---
V
I
C
V
E
H
D
LSV
L
---
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
PAS
V
R
E
G
I
N
I
-
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
---
R
I
A
D
A
--------------------------------
T
E
D
L
Q
N
D
S
A
S
R
-
A
F
S
Y
P
---
S
------------
L
K
K
T
Q
--
G
D
--
F
-
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
-
Q
D
I
--------------
P
K
-----
L
-----------------------------------------------
N
V
S
M
K
P
Q
-
K
I
A
P
K
----
F
----------------------------------------------------------------------
P
-------------------------------------
G
----
T
V
---
R
Q
L
F
F
K
-------
K
I
-
R
G
Q
F
L
---------
N
P
Q
-
F
Q
TDVVKPLRIDDIID
Q
E
V
Q
----
H
----------
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
---
I
C
----
S
K
V
I
R
R
F
ILHN
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.14
23%
-42
- C1 -
3J16
2
RLI1_YEAST
B:
[101-541]
------------------------------------------------------------------------------------------------------------
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
------------------------------------
N
L
--
G
----
R
F
D
D
P
P
E
W
Q
E
-
I
I
K
Y
F
R
G
--
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
-----------
D
-
N
I
P
R
A
---
I
-
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
-
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
-------
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
-
P
---
T
K
---
Y
---
V
I
C
V
E
H
D
L
S
V
L
---
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
PAS
V
R
E
G
I
N
I
-
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
---
R
I
A
D
A
--------------------------------
T
E
D
L
Q
N
D
S
A
S
R
-
A
F
S
Y
P
---
S
------------
L
K
K
T
Q
--
G
D
--
F
-
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
-
Q
D
I
--------------
P
K
-----
L
-----------------------------------------------
N
V
S
M
K
P
Q
-
K
I
A
P
K
----
F
----------------------------------------------------------------------
P
-------------------------------------
G
----
T
V
---
R
Q
L
F
F
K
-------
K
I
-
R
G
Q
F
L
---------
N
P
Q
-
F
Q
T
D
VVKPLRIDDIID
Q
E
V
Q
----
H
----------
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
---
I
C
----
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
-----------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
56.43
28%
-83
- C1 -
1OXS
23
?
C:
[1-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
-
V
S
K
V
F
KK
G
K
--
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
-
I
I
A
G
L
D
V
P
S
T
G
-
E
L
Y
FDDRLVASNGKLIV
P
P
-----
E
D
R
------------
K
------------
I
G
M
V
F
Q
T
-----
W
A
--
L
Y
--
P
N
L
T
A
F
E
-
N
I
A
F
P
----
L
----------------------------------------------------------------------
T
-------------------------------------
N
----
M
K
MS-
K
E
-
E
I
R
-------
K
R
-
V
E
E
V
A
----
K
I
LDI
H
H
V
-
L
N
--------------
H
F
P
R
----
E
----------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
---
S
A
----
R
A
L
V
K
E
V
----
Q
S
---
R
LGVT
L
L
V
V
S
H
D
P
A
D
-
I
F
A
I
A
-
D
R
-
V
G
V
L
V
K
G
K
-
L
V
Q
V
G
K
P
-
E
-
D
L
Y
-
D
N
P
V
SIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
63
Fugue
54.38
21%
-40
- C1 -
1YQT
4
?
A:
[24-538]
-----------------------------------------------------------------------
E
E
D
C
V
H
R
Y
G
-
V
-------
N
---
A
F
V
L
Y
R
L
P
V
------
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
--------
N
L
--
C
G
D
--
N
D
-
S
-----------
W
---
D
G
--
V
----
I
R
A
F
R
G
N
E
-------
L
Q
N
--
Y
F
E
K
L
K
N
G
E
I
R
P
-------
V
V
K
P
Q
Y
V
D
L
I
P
----
K
A
-
V
K
G
K
V
---
I
-
E
L
L
K
K
A
D
E
T
----------
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
-------
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
N
A
A
R
A
I
R
R
L
---
S
E
E
G
K
S
---
V
L
V
V
E
H
D
---
L
---
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
---------------------------
G
E
P
G
V
Y
G
I
F
S
Q
P
---
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
---------------------
P
R
-
L
V
K
D
Y
--
G
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
-
G
V
E
E
P
T
E
G
-
K
I
E
--------------
W
D
-----
L
T
---------------------------
V
A
Y
K
P
Q
-----
Y
I
-
K
A
D
--
Y
E
G
T
V
Y
E
-
L
L
S
K
I
----
D
----------------------------------------------------------------------
A
-------------------------------------
S
----
K
L
---
N
S
-
N
F
Y
-------
K
T
E
L
L
K
P
L
----
G
I
---
I
D
L
-
Y
D
--------------
R
E
V
N
----
E
----------
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
---
A
V
----
S
R
A
I
R
H
L
M
---
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
-
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
P
G
K
-
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
PDTG
R
P
R
A
N
K
EGS
V
K
D
R
E
Q
K
E
K
GEYYYIA--------------------------------------------------------------------------------
7
PsiBlast_PDB
52.59
32%
-107
- C1 -
4YMW
-
?
J:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVNINKVRQ
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
EAEELAV
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
51.07
32%
-104
- C1 -
4YMU
2
?
J:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVNINKVRQ
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
EAEELAV
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
50.68
32%
-103
- C1 -
4YMU
2
?
A:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVN
I
N
K
V
R
Q
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
E
A
E
E
L
A
V
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
E
GM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.30
32%
-104
- C1 -
4YMS
-
?
J:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVNINKVRQ
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
EAEELAV
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.04
32%
-102
- C1 -
4YMT
-
?
J:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVNINKVRQ
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
EAEELAV
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.24
32%
-102
- C1 -
4YMV
1
?
J:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVNINKVRQ
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
EAEELAV
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
47.87
32%
-99
- C1 -
4YMV
1
?
A:
[2-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
N
D
-
V
Y
K
N
F
--
G
S
--
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
-
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--------------
D
G
-----
V
K
I
NNGKVN
I
N
K
V
R
Q
K
------------
V
G
M
V
F
Q
------
H
F
-
N
L
F
--
P
H
L
T
A
I
E
-
N
I
T
L
A
----
P
----------------------------------------------------------------------
V
-------------------------------------
K
----
V
K
---
K
M
-
N
K
K
E
A
E
E
L
A
V
D
L
-
L
A
K
V
G
----
L
L
---
D
K
K
-
D
Q
--------------
Y
P
I
-----
K
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
---
E
V
----
L
N
V
M
K
Q
L
----
A
N
E
G
M
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
-
D
R
-
V
I
F
M
D
D
G
V
------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
46.23
33%
-92
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[10-198]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
-
C
L
A
G
F
E
Q
P
D
S
G
-
E
I
S
LSGKTIFSKNTNL-
P
V
-----
R
E
R
------------
R
------------
L
G
Y
L
V
Q
E
------
G
-
V
L
F
--
P
H
L
T
V
Y
R
-
N
I
A
Y
G
----
L
----------------------------------------------------------------------
G
-------------------------------------
N
----
G
K
GRT
A
Q
-
E
R
Q
-------
R
I
-
E
A
M
L
E
----
L
T
---
G
---
I
S
--------------
E
L
A
G
RYPH
E
----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
---
Q
I
REDM
I
A
A
L
R
A
N
----
G
K
---
S
----
A
V
F
V
S
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
45.92
33%
-91
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[10-203]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
S
F
--
Q
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
-
C
L
A
G
F
E
Q
P
D
S
G
-
E
I
S
L
SGKTIFSKN
T
N
L
-
P
V
-----
R
E
R
------------
R
------------
L
G
Y
L
V
Q
E
------
G
-
V
L
F
--
P
H
L
T
V
Y
R
-
N
I
A
Y
G
----
L
----------------------------------------------------------------------
G
-------------------------------------
N
----
G
K
GRT
A
Q
-
E
R
Q
-------
R
I
-
E
A
M
L
E
----
L
T
---
G
---
I
S
--------------
E
L
A
G
RYPH
E
----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
---
Q
I
R
E
D
M
I
A
A
L
R
A
N
----
G
K
---
S
----
A
V
F
V
S
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
38.37
31%
-75
- C1 -
2OLK
1
?
D:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
37.55
31%
-75
- C1 -
2OLK
2
?
B:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
36.76
32%
-96
- C1 -
4HLU
3
ECFA1_THEMA
C:
[15-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
-
V
S
F
R
Y
--
N
G
--
D
Y
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
-
I
L
A
G
L
L
A
A
A
G
E
-
I
F
L
--------------
D
G
SPADP
F
L
L
------------
R
KN----------
V
G
Y
V
F
Q
N
-----
P
S
-
S
Q
I
--
I
G
A
T
V
E
E
-
D
V
A
F
S
----
L
----------------------------------------------------------------------
E
-------------------------------------
I
----
M
G
LD-
E
S
-
E
M
R
-------
K
R
-
I
K
K
V
L
ELVG
L
S
---
G
L
A
-
A
A
--------------
D
P
L
-----
N
----------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
EIF
Q
V
----
L
E
S
L
K
N
E
----
G
K
---
G
----
I
I
L
V
T
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
36.67
31%
-78
- C1 -
2Q0H
4
?
B:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNL
N
K
V
R
E
E
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
E
GM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
36.62
31%
-75
- C1 -
2Q0H
4
?
A:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
E
G
M
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
36.33
31%
-80
- C1 -
3C41
3
?
K:
[9-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
36.08
31%
-76
- C1 -
2OLK
1
?
C:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
36.06
31%
-80
- C1 -
3C4J
4
?
B:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.66
31%
-79
- C1 -
2OLJ
4
?
A:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
E
GM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
35.00
31%
-76
- C1 -
2OLJ
3
?
B:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
34.02
31%
-72
- C1 -
3C4J
3
?
A:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTN
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
E
GM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
33.76
31%
-74
- C1 -
3C41
3
?
J:
[9-213]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AKDTNLNKVREE
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
EGM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
33.74
31%
-73
- C1 -
2OLK
1
?
A:
[30-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
S
F
--
G
S
--
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
-
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
--------------
D
G
-----
I
N
L
------------
K
AK
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
FNLFP
H
M
-
T
V
L
--
N
N
I
T
L
A
P
M
K
V
R
K
W
----
P
----------------------------------------------------------------------
R
-------------------------------------
E
----
K
A
---
E
A
-
K
A
M
-------
E
L
-
L
D
K
V
G
----
L
K
---
D
K
A
-
H
A
--------------
Y
P
-
D
----
S
----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
---
E
V
----
L
S
V
M
K
Q
L
----
A
N
E
GM
T
----
M
V
V
V
T
H
E
M
G
F
-
A
R
E
V
G
D
R
---
V
L
F
M
D
G
-------------------------------------------------------------------------------------------------------------------------------------------