@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1652: (2016-05-03 )
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
Atome Classification :
(20 SA)
.........10........20........30........40......---.---.50........60...-.-....70...--..--...80........90........-100...----.....110.......120.....----..130---.-----...-------.....140.--......150.......160.......170.-..--..----..-180.......190.......200.......210.......220.......230.......240.......250....------...260...--.--.....270...--....280..----..----...290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQNRQVAN
A
T
K
V
A
V
AGASGYA
G
G
E
I
L
R
L
L
LGHPAYADG
R
L
R
I
G
A
L
T
A---A---TSAGSTLGEHHP
H
L
T
P
-
L
-
A
H
RVVEPTE--
A
A
--
V
LGGH
D
A
V
F
L
A
LPHG
H
S
A
V
L
A
Q
Q-L-SP
E
T
----
L
I
I
DCGAD
F
R
L
T
D
A
A
V
W
E
R
F
YGS----SHA-----G-----SWP-------YGLPELPG
A
--
R
D
Q
LRGT
R
R
IAVPGC
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--IE----P
A
-
V
T
V
V
A
V
SGTSGAGR
A
A
T
T
D
L
L
G
A
E
V
IGSAR
A
Y
N
I
AGVHRH
T
P
E
I
A
Q
G
L
R
A
V
TDRDV
S
V
S
F
T
P
V
L
I
PASR
G
I
L
A
T
CTA------RTRS--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
AYHA--E
P
F
I
Y
L
MPE----GQ----LPRT
G
A
V
IGSN
A
A
H
I
A
V
A
VDEDA
Q
T
F
V
A
I
A
A
I
D
N
L
V
KGTAGA
A
V
Q
S
M
N
L
A
LGWPETDG
L
S
V
V
GVAP
2
PsiBlast_PDB
99.55
100%
-126
- C1 -
2I3G
2
ARGC_MYCTU
A:
[6-352]
-----
V
A
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
21
PsiBlast_CBE
99.18
100%
-126
- C1 -
2I3G
2
ARGC_MYCTU
B:
[8-352]
-------
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
22
PsiBlast_CBE
98.95
100%
-122
- C1 -
2I3A
1
ARGC_MYCTU
D:
[6-352]
-----
V
A
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
23
PsiBlast_CBE
98.84
100%
-127
- C1 -
2I3A
1
ARGC_MYCTU
C:
[9-352]
--------
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
24
PsiBlast_CBE
98.69
100%
-123
- C1 -
2I3A
1
ARGC_MYCTU
B:
[7-352]
------
A
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
1
PsiBlast_PDB
97.92
100%
-126
- C1 -
2I3A
1
ARGC_MYCTU
A:
[9-352]
--------
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
3
PsiBlast_PDB
97.60
99%
-121
- C1 -
2NQT
-
ARGC_MYCTU
A:
[6-352]
-----
V
A
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
P
G
A
--
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
-
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
-
D
L
--
I
E
----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
28
HHSearch
96.28
99%
-121
- C1 -
2NQT
-
ARGC_MYCTU
A:
[6-352]
-----
V
A
N
A
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
G
R
L
R
I
G
A
L
T
A
---
A
---
T
S
A
G
S
T
L
G
E
H
H
P
H
L
T
P
-
L
-
A
H
R
V
V
E
P
T
E
--
A
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
A
Q
Q
-
L
-
S
P
E
T
----
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
----
S
H
A
-----
G
-----
S
W
P
-------
Y
G
L
P
E
L
--
P
G
A
R
D
Q
L
R
G
T
R
R
I
A
V
P
G
-
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
--
E
-----
P
A
-
V
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
------
R
T
R
S
--
P
L
S
--
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
--
E
P
F
I
Y
L
M
P
E
----
G
Q
----
L
P
R
T
G
A
V
I
G
S
N
A
A
H
I
A
V
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
29
HHSearch
77.16
39%
-111
- C1 -
1XYG
-
ARGC_ARATH
A:
[15-359]
-------
K
D
I
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
F
-----
Q
V
T
L
M
T
A
---
D
---
R
K
A
G
Q
S
M
E
S
V
F
P
H
L
R
A
Q
K
-
L
P
T
L
V
S
V
K
---
D
A
--
D
F
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
I
K
E
-
L
-
P
T
A
L
----
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
----
P
H
K
A
V
E
L
Q
K
-----
E
V
V
-------
Y
G
L
T
E
I
--
L
--
R
E
D
I
K
K
A
R
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
N
L
I
KH
E
------
N
-
I
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
-
R
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
------
E
M
A
P
GV
R
T
E
--
D
--
L
H
Q
Q
L
K
T
S
Y
E
D
--
E
E
F
V
K
V
L
D
E
----
G
V
----
V
P
R
T
H
N
V
R
G
S
N
Y
C
H
M
S
V
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
L
H
Q
P
L
F
P
6
PsiBlast_PDB
76.69
38%
-113
- C1 -
2Q49
-
ARGC_ARATH
A:
[18-352]
----------
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
F
-----
Q
V
T
L
M
T
A
---
D
---
R
K
A
G
Q
S
M
E
S
V
F
P
H
L
R
A
-
Q
-
K
L
P
T
L
V
S
V
K
--
D
A
--
D
F
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
I
K
E
-
L
-
P
T
A
L
----
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
----
P
H
K
-----
A
VELQK
E
V
V
-------
Y
G
L
T
E
I
--
L
--
R
E
D
I
K
K
A
R
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
-
N
L
--
I
K
H---
E
N
-
I
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
R
-
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
E
M
A
PGV
R
T
E
D
--
L
H
Q
--
Q
--
L
K
T
S
Y
E
D
------
E
E
F
V
K
V
L
D
E
----
G
V
----
V
P
R
T
H
N
V
R
G
S
N
Y
C
H
M
S
V
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
-------
5
PsiBlast_PDB
76.39
38%
-112
- C1 -
1XYG
-
ARGC_ARATH
A:
[18-352]
----------
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
F
-----
Q
V
T
L
M
T
A
---
D
---
R
K
A
G
Q
S
M
E
S
V
F
P
H
L
R
A
-
Q
-
K
L
P
T
L
V
S
V
K
--
D
A
--
D
F
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
I
K
E
-
L
-
P
T
A
L
----
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
----
P
H
K
-----
A
V
E
L
Q
K
E
V
V
-------
Y
G
L
T
E
I
--
L
--
R
E
D
I
K
K
A
R
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
-
N
L
--
I
K
H---
E
N
-
I
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
R
-
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
E
M
A
P
GV
R
T
E
D
--
L
H
Q
--
Q
--
L
K
T
S
Y
E
D
------
E
E
F
V
K
V
L
D
E
----
G
V
----
V
P
R
T
H
N
V
R
G
S
N
Y
C
H
M
S
V
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
-------
30
HHSearch
75.58
39%
-107
- C1 -
5EIN
14
?
A:
[1-344]
------
M
D
K
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
L
-----
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
--
T
N
L
K
-
F
I
P
--
P
E
--
K
L
E
P
A
D
I
L
V
L
A
L
P
H
G
V
F
A
R
E
F
D
R
-
Y
S
A
L
A
P
----
I
L
I
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
-----
E
H
P
RPDLL
G
-----
C
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
A
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
G
V
L
KP
T
------
P
-
I
F
V
T
L
L
I
S
T
S
A
A
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
-
G
H
R
H
T
A
E
V
V
E
N
L
P
G
----
R
P
E
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
GW
S
E
R
--
D
--
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
KKGV
H
R
----
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
10
PsiBlast_PDB
74.72
36%
-106
- C1 -
5EIN
14
?
A:
[2-344]
-------
D
K
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
-
T
N
L
K
F
I
P
P
E
--
K
----
L
E
P
A
D
I
L
V
L
A
L
P
H
G
---
V
F
A
R
E
-
F
-
D
R
Y
S
A
L
AP
I
L
I
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
HPRP
D
L
L
-----
G
-----
C
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
A
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
-
G
V
--
L
K
----
P
T
P
I
F
V
T
L
L
I
S
T
S
A
A
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
R
P
E
----
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
--
G
W
S
--
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
----
K
K
GVHR
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
8
PsiBlast_PDB
74.40
36%
-106
- C1 -
5EIO
3
?
A:
[2-344]
-------
D
K
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
-
T
N
L
K
F
I
P
P
E
--
K
----
L
E
P
A
D
I
L
V
L
A
L
P
H
G
---
V
F
A
R
E
-
F
-
D
R
Y
S
ALAP
I
L
I
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
HPRP
D
L
L
-----
G
-----
C
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
C
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
-
G
V
--
L
K
----
P
T
P
I
F
V
T
L
L
I
S
T
S
A
A
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
R
P
E
----
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
--
G
W
S
--
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
----
K
K
GVHR
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
26
PsiBlast_CBE
74.38
36%
-111
- C1 -
5EIN
10
?
B:
[3-344]
--------
K
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
-
T
N
L
K
F
I
P
P
E
--
K
----
L
E
P
A
D
I
L
V
L
A
L
P
H
G
---
V
F
A
R
E
-
F
-
D
R
Y
S
A
L
AP
I
L
I
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
HPRP
D
L
L
-----
G
-----
C
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
A
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
-
G
V
--
L
K
----
P
T
P
I
F
V
T
L
L
I
S
T
S
A
A
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
R
P
E
----
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
--
G
W
S
--
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
----
K
K
GVHR
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
25
PsiBlast_CBE
73.99
36%
-107
- C1 -
5EIO
4
?
B:
[3-344]
--------
K
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
-
T
N
L
K
F
I
P
P
E
--
K
----
L
E
P
A
D
I
L
V
L
A
L
P
H
G
---
V
F
A
R
E
-
F
-
D
R
Y
S
A
L
AP
I
L
I
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
HPRP
D
L
L
-----
G
-----
C
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
C
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
-
G
V
--
L
K
----
P
T
P
I
F
V
T
L
L
I
S
T
S
A
A
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
R
P
E
----
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
--
G
W
S
--
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
----
K
K
GVHR
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
9
PsiBlast_PDB
73.34
36%
-110
- C1 -
2OZP
9
?
A:
[7-345]
-----------
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
---
R
F
A
G
E
P
V
H
F
V
H
P
N
L
R
G
-
R
-
T
N
L
K
F
V
P
P
E
--
K
----
L
E
P
A
D
I
L
V
L
A
L
P
H
G
---
V
F
A
R
E
-
F
-
D
R
Y
S
A
L
AP
V
L
V
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
HPRP
D
L
L
-----
G
-----
R
F
V
-------
Y
A
V
P
E
L
--
Y
--
R
E
A
L
K
G
A
D
W
I
A
G
A
G
C
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
-
G
V
--
L
K
----
P
T
P
I
F
V
T
L
L
I
S
T
S
A
G
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
R
P
E
----
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
------
F
V
Q
D
--
G
W
S
--
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
--
E
P
F
I
R
L
V
K
Q
----
K
K
GVHR
Y
P
D
P
R
F
V
Q
G
T
N
Y
A
D
I
G
F
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
33
HHSearch
70.74
38%
-111
- C1 -
3DR3
3
ARGC_SHIFL
A:
[3-337]
-------
A
M
L
N
T
L
I
V
G
A
S
G
Y
A
G
A
E
L
V
T
Y
V
N
R
H
P
H
M
-----
N
I
T
A
L
T
V
S
AQ
S
---
N
D
A
G
K
L
I
S
D
L
H
P
Q
L
K
G
-
I
V
E
L
P
L
Q
P
M
S
D
I-
S
E
--
F
S
P
G
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
A
P
Q
-
F
L
E
A
G
C
----
V
V
F
D
L
S
G
A
F
R
V
N
D
A
T
F
Y
E
K
Y
Y
G
F
----
T
H
Q
Y
P
E
L
L
E
-----
Q
A
A
-------
Y
G
L
A
E
W
--
C
--
G
N
K
L
K
E
A
N
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
A
L
K
P
L
I
D
A
D
L
L
--
D
L
----
N
Q
W
P
V
I
N
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
--
V
S
L
Q
P
Y
G
V
F
-
T
H
R
H
Q
P
E
I
A
T
H
L
G
-----
A
-
D
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
------
R
L
K
S
GV
T
Q
A
--
Q
--
V
A
Q
A
L
Q
Q
A
Y
A
H
--
K
P
L
V
R
L
Y
D
K
-----
G
----
V
P
A
L
K
N
V
V
G
L
P
F
C
D
I
G
F
A
V
Q
--
G
E
H
L
I
I
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
Y
A
E
T
Q
S
L
I
------
12
PsiBlast_PDB
70.44
35%
-111
- C1 -
2G17
10
ARGC_SALTY
A:
[9-336]
-------------
I
V
G
A
S
G
Y
A
G
A
E
L
V
S
Y
V
N
R
H
P
H
M
T
I
T
A
L
T
V
S
A
--
Q
---
S
---
N
D
A
G
K
L
I
S
D
L
H
P
Q
L
K
G
-
I
-
V
D
L
P
L
Q
P
M
S
--
D
V
RD
F
S
A
D
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
A
P
Q
F
L
-
Q
A
G
C
----
V
V
F
D
L
S
G
A
F
R
V
N
D
R
A
F
Y
E
K
Y
Y
G
F
----
T
H
------------
Q
Y
P
E
L
L
E
Q
AV
Y
G
L
A
E
W
--
N
--
V
D
K
L
N
T
A
N
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
S
L
K
P
L
I
D
G
-
G
L
--
L
D
LTQW
P
V
-
I
N
--
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
V
--
S
L
Q
P
Y
G
V
F
-
T
H
R
H
Q
P
E
I
A
V
H
L
G
A
------
E
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
------
R
L
K
A
--
G
V
T
H
A
Q
--
V
A
D
V
L
Q
K
A
Y
G
D
--
K
P
L
V
R
L
Y
D
K
----
G
-----
V
P
A
L
K
N
V
V
G
L
P
F
C
D
I
G
F
A
V
--
Q
G
E
H
L
I
V
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
F
A
E
T
Q
S
L
-------
11
PsiBlast_PDB
68.01
36%
-107
- C1 -
3DR3
3
ARGC_SHIFL
A:
[9-336]
-------------
I
V
G
A
S
G
Y
A
G
A
E
L
V
T
Y
V
N
R
H
P
-----
H
M
N
I
T
A
L
T
V
---
S
AQS
N
D
A
G
K
L
I
S
D
L
H
P
Q
L
K
G
-
I
-
V
E
L
P
L
Q
P
M
S
DI
S
E
--
F
S
P
G
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
A
P
Q
F
L
-
E
A
G
C
----
V
V
F
D
L
S
G
A
F
R
V
N
D
A
T
F
Y
E
K
Y
Y
G
F
----
T
H
------------
Q
Y
P
E
L
L
E
Q
AA
Y
G
L
A
E
W
C
G
----
N
K
L
K
E
A
N
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
A
L
K
P
L
I
D
A
-
D
L
--
L
D
LNQ
W
P
V
-
I
N
--
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
V
--
S
L
Q
P
Y
G
V
F
-
T
H
R
H
Q
P
E
I
A
T
H
L
G
A
------
D
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
------
R
L
K
S
--
G
V
T
--
Q
--
A
Q
V
A
Q
A
L
Q
Q
A
Y
AH
K
P
L
V
R
L
Y
D
K
----
G
-----
V
P
A
L
K
N
V
V
G
L
P
F
C
D
I
G
F
A
V
--
Q
G
E
H
L
I
I
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
Y
A
E
T
Q
S
L
-------