@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2964: (2016-05-15 )
MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGIIAAVSTFLARAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVADKFGIDYRFAEAAKPKRVAIMASTEDHCLLDLLWRNRRGELEMSVVMVIANHPDLAAHVRPFGVPFIHIPATRDTRTEAEQRQLQLLSGNVDLVVLARYMQILSPGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGVKLIGATAHYVTEVLDEGPIIEQDVVRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQDRVIVHHNQTIVF
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70.......------.80..-....--..90.......-.100.......110.......120.......130.......140.......150.--.--.-.--.--..160.-......-170..-......180-.-....-.-.-190........200.......210.......220.......230.......240.......250.......260.....---..270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKGSMTAHATPNEPDYPPPPGGPP
P
P
A
D
I
G
R
L
L
L
RCHDRP
G
I
I
A
A
V
S
T
F
L
A
RAGA
N
I
I
S
LDQHSTAPE
G
G
T
F
L
Q
R
A
I
------
F
HLPG-
L
T
A
A
--
V
D
E
L
Q
R
D
F
G
S
T
-
V
A
D
KFGID
Y
R
FAEAAKP
K
R
V
A
I
M
ASTE
D
H
C
L
L
D
L
L
W
RNRRG
E
L
E
M
S
V
V
M
V
IANHP--D--
L
-
A
--A--HVRPFG-V
P
F
I
H
I-P-ATR-DTR
T
E
A
E
Q
R
-
Q
-
L
Q
L
L-S-G-N-
V
D
L
V
V
L
A
R
Y
M
Q
IL
S
P
G
F
L
E
A
IGC
P
L
I
N
I
H
H
S
F
L
P
A
FTGA
A
P
Y
Q
R
A
R
ERG
V
K
L
IG
A
T
A
H
Y
V
T
E
V
LDEGPII
E
Q
D
V
VRV---DHTH
T
V
D
D
L
V
R
VG
A
D
V
E
R
A
V
L
S
R
A
V
L
W
HCQ
D
R
V
I
V
HHN
Q
T
I
VF
105
HHSearch
97.45
58%
-146
- C4 -
3W7B
-
?
A:
[1-284]
---------------------------
M
E
E
A
R
L
L
V
T
C
P
D
R
P
G
I
V
A
A
V
S
G
F
L
Y
A
H
G
A
N
I
T
D
L
Q
Q
H
S
T
D
P
E
G
G
T
F
F
M
R
V
A
------
F
T
A
S
H
L
D
L
-
A
--
R
P
A
L
E
R
A
F
Q
-
E
V
V
A
S
R
F
Q
M
Q
W
R
L
A
Y
A
S
E
R
K
R
T
A
I
L
V
S
K
P
A
H
A
L
L
E
L
L
W
R
Y
R
V
G
E
L
P
M
E
L
R
L
V
I
S
N
H
P
--
D
--
H
-
R
--
E
--
E
V
E
R
F
G
-
I
P
Y
H
H
V
-
P
-
V
E
K
-
G
R
K
E
E
A
E
E
R
-
I
-
L
A
L
L
-
E
A
E
-
G
-
V
E
L
V
V
L
A
R
Y
M
Q
I
L
S
P
G
F
V
E
R
F
P
M
R
I
I
N
I
H
H
S
F
L
P
A
F
A
G
A
D
P
Y
R
Q
A
Y
E
R
G
V
K
L
I
G
A
T
A
H
Y
V
T
E
E
L
D
Q
G
P
I
I
E
Q
D
V
V
R
V
---
S
H
R
H
S
V
R
E
M
K
R
L
G
R
E
L
E
R
T
V
L
A
R
A
V
R
W
H
L
E
D
R
I
L
V
H
E
N
R
T
V
V
F
1
PsiBlast_PDB
97.19
58%
-146
- C4 -
3W7B
-
?
A:
[4-284]
------------------------------
A
R
L
L
V
T
C
P
D
R
P
G
I
V
A
A
V
S
G
F
L
Y
A
H
G
A
N
I
T
D
L
Q
Q
H
S
T
D
P
E
G
G
T
F
F
M
R
V
A
------
F
T
A
S
H
-
L
D
L
A
--
R
P
A
L
E
R
A
F
Q
E
V
-
V
A
S
R
F
Q
M
Q
W
R
L
A
Y
A
S
E
R
K
R
T
A
I
L
V
S
K
P
A
H
A
L
L
E
L
L
W
R
Y
R
V
G
E
L
P
M
E
L
R
L
V
I
S
N
H
P
--
D
--
H
-
R
--
E
--
E
V
E
R
F
G
-
I
P
Y
H
H
V
-
P
-
V
E
K
-
G
R
K
E
E
A
E
E
R
-
I
-
L
A
L
L
-
E
-
A
-
E
G
V
E
L
V
V
L
A
R
Y
M
Q
I
L
S
P
G
F
V
E
R
F
P
M
R
I
I
N
I
H
H
S
F
L
P
A
F
A
G
A
D
P
Y
R
Q
A
Y
E
R
G
V
K
L
I
G
A
T
A
H
Y
V
T
E
E
L
D
Q
G
P
I
I
E
Q
D
V
V
R
V
---
S
H
R
H
S
V
R
E
M
K
R
L
G
R
E
L
E
R
T
V
L
A
R
A
V
R
W
H
L
E
D
R
I
L
V
H
E
N
R
T
V
V
F
103
HHSearch
92.33
45%
-151
- C4 -
3O1L
12
?
A:
[16-301]
-----------------------
Y
F
Q
G
M
R
T
F
R
L
V
I
A
C
P
D
R
V
G
I
V
A
K
V
S
N
F
L
A
S
H
N
G
W
I
T
E
A
S
H
H
S
D
-
N
L
S
G
W
F
F
M
R
H
E
------
I
R
A
D
T
-
L
P
F
D
--
L
D
G
F
R
E
A
F
T
-
P
-
I
A
E
E
F
S
M
D
W
R
I
T
D
S
A
Q
K
K
R
V
V
L
M
A
S
R
E
S
H
C
L
A
D
L
L
H
R
W
H
S
D
E
L
D
C
D
I
A
C
V
I
S
N
H
Q
--
D
--
L
-
R
--
S
--
M
V
E
W
H
D
-
I
P
Y
Y
H
V
-
P
-
V
D
P
-
K
D
K
E
P
A
F
A
E
-
V
-
S
R
L
V
-
G
H
H
-
Q
-
A
D
V
V
V
L
A
R
Y
M
Q
I
L
P
P
Q
L
C
R
E
Y
A
H
Q
V
I
N
I
H
H
S
F
L
P
S
F
V
G
A
K
P
Y
H
Q
A
S
L
R
G
V
K
L
I
G
A
T
C
H
Y
V
T
E
E
L
D
A
G
P
I
I
E
Q
D
V
V
R
V
---
S
H
R
D
S
I
E
N
M
V
R
F
G
R
D
V
E
K
M
V
L
A
R
G
L
R
A
H
L
E
D
R
V
L
V
H
D
N
K
T
V
V
F
104
HHSearch
90.27
43%
-148
- C4 -
3LOU
15
?
A:
[8-291]
---------------------------
P
H
Q
F
V
L
T
L
S
C
P
S
A
A
G
Q
V
A
A
V
V
G
L
L
D
R
H
R
C
Y
V
D
E
L
T
V
F
D
D
-
D
L
S
A
R
F
F
V
R
C
V
------
F
H
A
T
D
--
L
-
R
--
V
D
A
L
R
R
E
F
E
-
P
-
I
A
E
R
F
R
M
Q
W
A
I
H
D
V
A
A
R
P
K
V
L
I
M
V
S
K
L
E
H
C
L
A
D
L
L
F
R
W
K
M
G
E
L
K
M
D
I
V
G
I
V
S
N
H
P
--
D
--
F
-
A
--
P
--
L
A
A
Q
H
G
-
L
P
F
R
H
F
-
P
-
I
T
A
-
D
T
K
A
Q
Q
E
A
Q
-
W
-
L
D
V
F
-
E
T
S
-
G
-
A
E
L
V
I
L
A
R
Y
M
Q
V
L
S
P
E
A
S
A
R
L
A
N
R
A
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
H
A
R
G
V
K
L
I
G
A
T
A
H
F
V
T
D
D
L
D
E
G
P
I
I
E
Q
V
V
E
R
V
---
D
H
S
Y
R
P
E
Q
L
L
A
V
G
R
D
V
E
C
I
T
L
A
R
A
V
K
A
F
I
E
R
R
V
F
L
N
G
D
R
T
V
V
F
4
PsiBlast_PDB
90.01
44%
-151
- C4 -
3O1L
12
?
A:
[24-301]
-------------------------------
R
L
V
I
A
C
P
D
R
V
G
I
V
A
K
V
S
N
F
L
A
S
H
N
G
W
I
T
E
A
S
H
H
S
D
N
L
S
G
W
F
F
M
R
H
E
I
RADTLP
F
D
L
D
G
-
F
R
E
A
--
F
--------
T
P
-
I
A
E
E
F
S
M
D
W
R
I
T
D
S
A
Q
K
K
R
V
V
L
M
A
S
R
E
S
H
C
L
A
D
L
L
H
R
W
H
S
D
E
L
D
C
D
I
A
C
V
I
S
N
H
Q
--
D
--
L
-
R
--
S
--
M
V
E
W
H
D
-
I
P
Y
Y
H
V
-
P
-
V
D
P
-
K
D
K
E
P
A
F
A
E
-
V
-
S
R
L
V
-
G
-
H
-
H
Q
A
D
V
V
V
L
A
R
Y
M
Q
I
L
P
P
Q
L
C
R
E
Y
A
H
Q
V
I
N
I
H
H
S
F
L
P
S
F
V
G
A
K
P
Y
H
Q
A
S
L
R
G
V
K
L
I
G
A
T
C
H
Y
V
T
E
E
L
D
A
G
P
I
I
E
Q
D
V
V
R
V
---
S
H
R
D
S
I
E
N
M
V
R
F
G
R
D
V
E
K
M
V
L
A
R
G
L
R
A
H
L
E
D
R
V
L
V
H
D
N
K
T
V
V
F
5
PsiBlast_PDB
89.92
42%
-154
- C4 -
3LOU
15
?
A:
[13-291]
--------------------------------
L
T
L
S
C
P
S
A
A
G
Q
V
A
A
V
V
G
L
L
D
R
H
R
C
Y
V
D
E
L
T
V
F
D
D
-
D
L
S
A
R
F
F
V
R
C
V
------
F
H
A
T
D
-----LR
V
D
A
L
R
R
E
F
-
E
P
-
I
A
E
R
F
R
M
Q
W
A
I
H
D
V
A
A
R
P
K
V
L
I
M
V
S
K
L
E
H
C
L
A
D
L
L
F
R
W
K
M
G
E
L
K
M
D
I
V
G
I
V
S
N
H
P
--
D
--
F
-
A
--
P
--
L
A
A
Q
H
G
-
L
P
F
R
H
F
-
P
-
I
T
A
-
D
T
K
A
Q
Q
E
A
Q
-
W
-
L
D
V
F
E
T
-
S
-
G
-
A
E
L
V
I
L
A
R
Y
M
Q
V
L
S
P
E
A
S
A
R
L
A
N
R
A
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
H
A
R
G
V
K
L
I
G
A
T
A
H
F
V
T
D
D
L
D
E
G
P
I
I
E
Q
V
V
E
R
V
---
D
H
S
Y
R
P
E
Q
L
L
A
V
G
R
D
V
E
C
I
T
L
A
R
A
V
K
A
F
I
E
R
R
V
F
L
N
G
D
R
T
V
V
F
2
PsiBlast_PDB
89.72
46%
-144
- C4 -
3OBI
9
?
A:
[9-286]
--------------------------------
L
T
L
S
C
P
D
R
A
G
I
V
S
A
V
S
T
F
L
F
E
N
G
Q
N
I
L
D
A
Q
Q
Y
N
D
T
-
E
S
G
H
F
F
M
R
V
V
------
F
N
A
A
A
-
K
V
I
P
--
L
A
S
L
R
T
G
F
G
-
V
-
I
A
A
K
F
T
M
G
W
H
M
R
D
R
E
T
R
R
K
V
M
L
L
V
S
Q
S
D
H
C
L
A
D
I
L
Y
R
W
R
V
G
D
L
H
M
I
P
T
A
I
V
S
N
H
P
--
R
--
E
-
T
--
F
--
S
G
F
D
F
G
D
I
P
F
Y
H
F
-
P
-
V
N
K
-
D
T
R
R
Q
Q
E
A
A
-
I
-
T
A
L
I
-
A
Q
T
-
H
-
T
D
L
V
V
L
A
R
Y
M
Q
I
L
S
D
E
M
S
A
R
L
A
G
R
C
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
F
D
R
G
V
K
L
I
G
A
T
A
H
Y
V
T
S
A
L
D
E
G
P
I
I
D
Q
D
V
E
R
I
---
S
H
R
D
T
P
A
D
L
V
R
K
G
R
D
I
E
R
R
V
L
S
R
A
L
H
Y
H
L
D
D
R
V
I
L
N
G
R
K
T
V
V
F
107
HHSearch
89.22
46%
-140
- C4 -
3OBI
9
?
A:
[4-286]
---------------------------
H
H
Q
Y
V
L
T
L
S
C
P
D
R
A
G
I
V
S
A
V
S
T
F
L
F
E
N
G
Q
N
I
L
D
A
Q
Q
Y
N
D
-
T
E
S
G
H
F
F
M
R
V
V
------
F
N
A
A
A
-
K
V
I
P
--
L
A
S
L
R
T
G
F
G
-
V
-
I
A
A
K
F
T
M
G
W
H
M
R
D
R
E
T
R
R
K
V
M
L
L
V
S
Q
S
D
H
C
L
A
D
I
L
Y
R
W
R
V
G
D
L
H
M
I
P
T
A
I
V
S
N
H
P
--
R
--
E
T
F
--
S
--
G
F
D
F
G
D
-
I
P
F
Y
H
F
-
P
-
V
N
K
-
D
T
R
R
Q
Q
E
A
A
-
I
-
T
A
L
I
-
A
Q
T
-
H
-
T
D
L
V
V
L
A
R
Y
M
Q
I
L
S
D
E
M
S
A
R
L
A
G
R
C
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
F
D
R
G
V
K
L
I
G
A
T
A
H
Y
V
T
S
A
L
D
E
G
P
I
I
D
Q
D
V
E
R
I
---
S
H
R
D
T
P
A
D
L
V
R
K
G
R
D
I
E
R
R
V
L
S
R
A
L
H
Y
H
L
D
D
R
V
I
L
N
G
R
K
T
V
V
F
3
PsiBlast_PDB
87.82
46%
-144
- C4 -
3NRB
5
?
A:
[10-285]
--------------------------------
L
S
L
A
C
Q
D
A
P
G
I
V
S
E
V
S
T
F
L
F
N
N
G
A
N
I
V
E
A
E
Q
F
N
D
-
E
D
S
S
K
F
F
M
R
V
S
------
V
E
I
P
--------
V
N
D
F
N
S
A
F
G
K
V
-
V
-
E
K
Y
N
A
E
W
W
F
R
P
R
T
D
R
K
K
V
V
I
M
V
S
K
F
D
H
C
L
G
D
L
L
Y
R
H
R
L
G
E
L
D
M
E
V
V
G
I
I
S
N
H
P
--
R
--
E
-
A
--
L
--
S
V
S
L
V
G
D
I
P
F
H
Y
L
-
P
-
V
T
P
-
A
T
K
A
A
Q
E
S
Q
-
I
-
K
N
I
V
-
T
Q
S
-
Q
-
A
D
L
I
V
L
A
R
Y
M
Q
I
L
S
D
D
L
S
A
F
L
S
G
R
C
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
H
T
R
G
V
K
L
I
G
A
T
A
H
F
V
T
A
D
L
D
E
G
P
I
I
A
Q
D
V
E
H
V
---
S
H
R
D
S
A
E
D
L
V
R
K
G
R
D
I
E
R
R
V
L
S
R
A
V
L
L
F
L
E
D
R
L
I
V
N
G
E
R
T
V
V
F
106
HHSearch
86.98
46%
-137
- C4 -
3NRB
5
?
A:
[4-285]
--------------------------
K
N
N
Q
Y
V
L
S
L
A
C
Q
D
A
P
G
I
V
S
E
V
S
T
F
L
F
N
N
G
A
N
I
V
E
A
E
Q
F
N
D
-
E
D
S
S
K
F
F
M
R
V
S
------
V
E
I
P
--------
V
N
D
F
N
S
A
F
G
-
K
-
V
V
E
K
Y
N
A
E
W
W
F
R
P
R
T
D
R
K
K
V
V
I
M
V
S
K
F
D
H
C
L
G
D
L
L
Y
R
H
R
L
G
E
L
D
M
E
V
V
G
I
I
S
N
H
P
--
R
--
E
A
L
--
S
--
V
S
L
V
G
D
-
I
P
F
H
Y
L
-
P
-
V
T
P
-
A
T
K
A
A
Q
E
S
Q
-
I
-
K
N
I
V
-
T
Q
S
-
Q
-
A
D
L
I
V
L
A
R
Y
M
Q
I
L
S
D
D
L
S
A
F
L
S
G
R
C
I
N
I
H
H
S
F
L
P
G
F
K
G
A
K
P
Y
H
Q
A
H
T
R
G
V
K
L
I
G
A
T
A
H
F
V
T
A
D
L
D
E
G
P
I
I
A
Q
D
V
E
H
V
---
S
H
R
D
S
A
E
D
L
V
R
K
G
R
D
I
E
R
R
V
L
S
R
A
V
L
L
F
L
E
D
R
L
I
V
N
G
E
R
T
V
V
F
9
PsiBlast_PDB
68.41
32%
-137
- C4 -
3AUF
-
?
A:
[3-200]
------------------------------------------------------------------------------------------------------------------------------
R
I
G
V
L
I
S
G
S
G
T
N
L
Q
A
I
L
D
G
C
R
E
G
R
I
P
G
R
V
A
V
V
I
S
D
R
A
--
D
--
A
-
Y
--
G
L
E
R
A
R
R
A
G
-
V
D
A
L
H
M
D
P
-
A
A
Y
-
P
S
R
T
A
F
D
A
A
-
L
-
A
E
R
L
-
Q
-
A
Y
G
-
V
D
L
V
C
L
A
G
Y
M
R
L
V
R
G
P
M
L
T
A
F
P
N
R
I
L
N
I
H
P
S
L
L
P
A
F
P
G
L
E
A
Q
R
Q
A
L
E
H
G
V
K
V
A
G
C
T
V
H
F
V
T
A
G
V
D
E
G
P
I
I
L
Q
A
A
V
P
V
---
L
E
G
D
T
V
E
D
L
R
R
R
I
L
A
E
E
H
R
I
Y
P
E
A
I
R
L
F
A
E
G
R
L
V
I
E
G
R
R
V
R
I
L
116
HHSearch
66.30
28%
-142
- C4 -
3TQR
1
?
A:
[4-200]
---------------------------------------------------------------------------------------------------------------------------
E
P
L
P
I
V
V
L
I
S
G
N
G
T
N
L
Q
A
I
I
G
A
I
Q
K
G
-
L
A
I
E
I
R
A
V
I
S
N
R
A
--
D
A
Y
G
-
L
--
K
--
R
A
Q
Q
A
D
-
I
P
T
H
I
I
-
P
-
H
E
E
F
P
S
R
T
D
F
E
S
T
-
L
-
Q
K
T
I
-
D
H
Y
-
D
-
P
K
L
I
V
L
A
G
F
M
R
K
L
G
K
A
F
V
S
H
Y
S
G
R
M
I
N
I
H
P
S
L
L
P
K
Y
T
G
L
N
T
H
E
R
A
L
A
A
G
E
T
E
H
G
V
S
V
H
Y
V
T
-
D
L
D
A
G
P
L
I
C
Q
A
R
L
S
I
---
T
P
Q
D
T
P
E
T
L
K
T
R
V
H
A
L
E
H
I
I
Y
P
E
V
L
S
W
F
A
A
G
R
L
N
Y
H
N
N
Q
V
---
117
HHSearch
66.22
28%
-142
- C4 -
1JKX
1
PUR3_ECOLI
A:
[1-195]
-----------------------------------------------------------------------------------------------------------------------------
M
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
C
K
T
N
K
I
K
G
T
V
R
A
V
F
S
N
K
A
--
D
A
F
G
-
L
--
E
--
R
A
R
Q
A
G
-
I
A
T
H
T
L
-
I
-
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
-
I
H
E
I
-
D
M
Y
-
A
-
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
A
----
113
HHSearch
66.06
30%
-142
- C4 -
3P9X
6
?
A:
[3-192]
-----------------------------------------------------------------------------------------------------------------------------
K
R
V
A
I
F
A
S
G
S
G
T
N
A
E
A
I
I
Q
S
Q
K
A
G
Q
L
P
C
E
V
A
L
L
I
T
D
K
P
--
G
A
K
V
-
V
--
E
--
R
V
K
V
H
E
-
I
P
V
C
A
L
-
D
-
P
K
T
Y
P
S
K
E
A
Y
E
I
E
-
V
-
V
Q
Q
L
-
K
E
K
-
Q
-
I
D
F
V
V
L
A
G
Y
M
R
L
V
G
P
T
L
L
G
A
Y
E
G
R
I
V
N
I
H
P
S
L
L
P
A
F
P
G
L
H
A
I
E
Q
A
I
R
A
N
V
K
V
T
G
V
T
I
H
Y
V
D
E
G
M
D
T
G
P
I
I
A
Q
E
A
V
S
I
---
E
E
E
D
T
L
E
T
L
T
T
K
I
Q
A
V
E
H
R
L
Y
P
A
T
L
H
K
L
L
S
K
A
E
N
---------
109
HHSearch
66.05
32%
-133
- C4 -
2YWR
5
?
A:
[1-199]
----------------------------------------------------------------------------------------------------------------------------
M
L
K
I
G
V
L
V
S
G
R
G
S
N
L
Q
A
I
I
D
A
I
E
S
G
K
V
N
A
S
I
E
L
V
I
S
D
N
P
KA
Y
--
A
-
I
--
E
--
R
C
K
K
H
N
-
V
E
C
K
V
I
-
Q
-
R
K
E
F
P
S
K
K
E
F
E
E
R
-
M
-
A
L
E
L
-
K
K
K
-
G
-
V
E
L
V
V
L
A
G
F
M
R
I
L
S
H
N
F
L
K
Y
F
P
N
K
V
I
N
I
H
P
S
L
I
P
A
F
Q
G
L
H
A
Q
K
Q
A
V
E
F
G
V
K
F
S
G
C
T
V
H
I
V
D
E
S
V
D
A
G
P
V
I
V
Q
A
V
V
P
V
---
L
P
E
D
D
E
N
T
L
A
D
R
I
L
K
W
E
H
K
I
L
P
Q
T
V
Q
W
F
A
Q
D
R
I
I
I
D
G
R
K
V
I
V
-
115
HHSearch
63.79
30%
-144
- C4 -
3KCQ
1
?
A:
[7-200]
---------------------------------------------------------------------------------------------------------------------------
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
F
S
T
-
E
S
S
V
V
I
S
C
V
I
S
N
N
A
--
E
A
R
G
-
L
--
L
--
I
A
Q
S
Y
G
-
I
P
T
F
V
V
-
K
-
R
K
P
-----
L
D
I
E
H
-
I
-
S
T
V
L
-
R
E
H
-
D
-
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
---
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
--
8
PsiBlast_PDB
63.18
33%
-145
- C4 -
3P9X
5
?
A:
[3-167]
-----------------------------------------------------------------------------------------------------------------------------
K
R
V
A
I
F
A
S
G
S
G
T
N
A
E
A
I
I
Q
S
Q
K
A
G
Q
L
P
C
E
V
A
L
L
I
T
D
K
P
GA
K
--
V
-
V
--
E
--
R
V
K
V
H
E
-
I
P
V
C
A
L
D
P
-
K
T
Y
-
P
S
K
E
A
Y
E
I
E
-
V
-
V
Q
Q
L
-
K
E
K
-
Q
-
I
D
F
V
V
L
A
G
Y
M
R
L
V
G
P
T
L
L
G
A
Y
E
G
R
I
V
N
I
H
P
S
L
L
P
A
F
P
G
L
H
A
I
E
Q
A
I
R
A
N
V
K
V
T
G
V
T
I
H
Y
V
D
E
G
M
D
T
G
P
I
I
A
Q
E
A
V
S
I
---
E
E
E
D
T
L
E
T
L
----------------------------------
111
HHSearch
63.16
29%
-136
- C4 -
4ZZ1
2
A:
[2-194]
-----------------------------------------------------------------------------------------------------------------------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
--
A
--
V
-
A
G
L
D
--
K
A
E
R
A
G
-
I
P
T
R
V
I
-
N
-
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
-
D
L
V
L
-
E
E
F
-
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
-
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
G
E
------
112
HHSearch
63.10
27%
-153
- C4 -
4S1N
3
?
A:
[4-183]
----------------------------------------------------------------------------------------------------------------------------
M
K
K
I
A
V
F
A
S
G
N
G
S
N
F
Q
V
I
A
E
E
-------
F
P
V
E
F
V
F
S
D
H
R
--
D
AY
V
-
L
--
E
--
R
A
K
Q
L
G
-
V
L
S
Y
A
F
-
E
-
L
K
E
F
E
S
K
A
D
Y
E
A
A
-
L
-
V
E
L
L
-
E
E
H
-
Q
-
I
D
L
V
C
L
A
G
Y
M
K
I
V
G
P
T
L
L
S
A
Y
E
G
R
I
V
N
I
H
P
A
Y
L
P
E
F
P
G
A
H
G
I
E
D
A
W
N
A
G
V
G
Q
S
G
V
T
I
H
W
V
D
S
G
V
D
T
G
Q
V
I
K
Q
V
R
V
P
R
---
L
A
D
D
T
I
D
R
F
E
A
R
I
H
E
A
E
Y
R
L
Y
P
E
V
V
K
A
L
F
T
-------------
7
PsiBlast_PDB
62.94
33%
-136
- C4 -
2YWR
5
?
A:
[3-199]
------------------------------------------------------------------------------------------------------------------------------
K
I
G
V
L
V
S
G
R
G
S
N
L
Q
A
I
I
D
A
I
E
S
G
K
V
N
A
S
I
E
L
V
I
S
D
N
P
--
K
--
A
-
Y
--
A
I
E
R
C
K
K
H
N
-
V
E
C
K
V
I
-
Q
-
R
K
E
F
P
S
K
K
E
F
E
E
R
-
M
A
L
E
L
K
-
K
-
K
-
G
-
V
E
L
V
V
L
A
G
F
M
R
I
L
S
H
N
F
L
K
Y
F
P
N
K
V
I
N
I
H
P
S
L
I
P
A
F
Q
G
L
H
A
Q
K
Q
A
V
E
F
G
V
K
F
S
G
C
T
V
H
I
V
D
E
S
V
D
A
G
P
V
I
V
Q
A
V
V
P
V
L
PE
D
D
E
N
T
L
A
D
R
I
---
L
K
W
E
H
K
I
L
P
Q
T
V
Q
W
F
A
Q
D
R
I
I
I
D
G
R
K
V
I
V
-
56
PsiBlast_CBE
57.81
32%
-137
- C4 -
4ZZ2
2
A:
[3-166]
------------------------------------------------------------------------------------------------------------------------------
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
--
A
--
V
-
A
--
G
L
D
K
A
E
R
A
G
-
I
P
T
R
V
I
-
N
H
K
L
Y
-
K
N
R
V
E
F
D
S
A
I
D
-
L
V
L
E
-
E
-
F
-
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
40
PsiBlast_CBE
57.55
32%
-134
- C4 -
1RC0
1
PUR2_HUMAN
A:
[2-165]
------------------------------------------------------------------------------------------------------------------------------
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
--
A
--
V
-
A
--
G
L
D
K
A
E
R
A
G
-
I
P
T
R
V
I
-
N
H
K
L
Y
-
K
N
R
V
E
F
D
S
A
I
D
-
L
V
L
E
-
E
-
F
-
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
36
PsiBlast_CBE
56.45
32%
-135
- C4 -
1ZLY
2
A:
[2-165]
------------------------------------------------------------------------------------------------------------------------------
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
S
N
K
A
--
A
--
V
-
A
--
G
L
D
K
A
E
R
A
G
-
I
P
T
R
V
I
-
N
H
K
L
Y
-
K
N
R
V
E
F
D
S
A
I
D
-
L
V
L
E
-
E
-
F
-
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
13
PsiBlast_PDB
46.66
36%
-118
- C4 -
1C2T
2
PUR3_ECOLI
A:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
29
PsiBlast_CBE
46.64
36%
-116
- C4 -
1CDE
2
PUR3_ECOLI
B:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
27
PsiBlast_CBE
46.63
36%
-116
- C4 -
1CDE
2
PUR3_ECOLI
D:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
28
PsiBlast_CBE
46.61
36%
-116
- C4 -
1CDE
2
PUR3_ECOLI
C:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
15
PsiBlast_PDB
46.59
36%
-116
- C4 -
1CDE
2
PUR3_ECOLI
A:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
19
PsiBlast_PDB
46.14
36%
-117
- C4 -
1C3E
2
PUR3_ECOLI
A:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
31
PsiBlast_CBE
45.41
36%
-116
- C4 -
1C2T
2
PUR3_ECOLI
B:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
32
PsiBlast_CBE
44.73
36%
-116
- C4 -
1C3E
2
PUR3_ECOLI
B:
[81-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
---
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
E
N
-----
59
PsiBlast_CBE
43.63
41%
-114
- C4 -
1MEN
1
PUR2_HUMAN
B:
[90-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
58
PsiBlast_CBE
43.07
41%
-112
- C4 -
1MEN
1
C:
[90-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
63
PsiBlast_CBE
42.63
41%
-112
- C4 -
1MEJ
1
PUR2_HUMAN
A:
[90-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
61
PsiBlast_CBE
42.53
41%
-112
- C4 -
1MEJ
1
C:
[90-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------
60
PsiBlast_CBE
40.94
41%
-105
- C4 -
1MEN
1
PUR2_HUMAN
A:
[90-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
---
K
R
G
D
T
V
A
T
L
----------------------------------