@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3548c: (2016-05-21 )
MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA
Atome Classification :
(25 SA)
.........10........20........30........40.......--.50........60........70........80........90........100.......110.......120.......130.......140.......150...---....160.....------..170.......180.......190.......200..---------.-..-..210---.......---.------------220-.---.......230-.-------........240.-......250......-.260.......270.......280.......290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGLVDG
R
V
V
I
V
TGAGGGI
G
R
A
H
A
L
AFAAEG
A
R
V
V
V
N
DIGVGLDGSPAS--GG
S
A
A
Q
D
V
V
D
E
I
L
A
AGGQAVADGSDI
S
D
W
D
Q
A
A
N
L
I
Q
A
A
V
E
TYG
G
V
D
V
L
VNNAG
I
V
R
DRMIANT
S
E
E
E
F
D
A
V
I
A
V
H
LK
G
H
F
A
T
M
R
H
A
A
S
H
W
R
G
L
S
KAGKAPKDI
D
A
R
---
I
I
NTSSGAGLQG------SVGQGN
Y
S
A
A
K
A
G
I
A
A
L
T
L
V
G
A
A
E
M
R
RYG
V
T
V
N
A
IAP---------
A
-
A
R
-T
R
M
T
----
E
T
V
F
A
E
M
---M------------AK--P---QEGFDAMA---P-------ENV
S
P
L
V
V
W
LGS-AESRDVT
G
K
V
F
E
VEG-
G
I
I
R
VAEGWAHGPQVDKGVKW
D
P
A
E
L
G
P
V
V
S
D
L
L
AKSRPPVPVYGA
25
PsiBlast_CBE
97.17
88%
-89
- C2 -
3QLJ
3
?
B:
[22-322]
M
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
----------------------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
21
PsiBlast_CBE
96.15
88%
-90
- C2 -
3QLJ
2
?
F:
[23-322]
-
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-------------------------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
109
HHSearch
95.64
89%
-86
- C2 -
3QLJ
5
?
A:
[23-322]
-
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
---
A
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
M
T
----
E
T
V
F
A
E
----------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
24
PsiBlast_CBE
95.45
88%
-86
- C2 -
3QLJ
4
?
C:
[22-322]
M
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
M
T
----
E
T
V
F
------------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
1
PsiBlast_PDB
95.30
88%
-86
- C2 -
3QLJ
5
?
A:
[22-322]
M
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
M
T
----
E
T
V
F
A
E
----------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
22
PsiBlast_CBE
95.05
88%
-86
- C2 -
3QLJ
4
?
E:
[23-322]
-
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
M
T
----
E
T
--------------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
23
PsiBlast_CBE
94.33
88%
-86
- C2 -
3QLJ
5
?
D:
[23-322]
-
G
V
V
D
G
R
V
V
I
V
T
G
A
G
G
G
I
G
R
A
H
A
L
A
F
A
A
E
G
A
R
V
V
V
N
D
I
G
V
G
L
D
G
S
P
A
S
--
G
G
S
A
A
Q
S
V
V
D
E
I
T
A
A
G
G
E
A
V
A
D
G
S
N
V
A
D
W
D
Q
A
A
G
L
I
Q
T
A
V
E
T
F
G
G
L
D
V
L
V
N
N
A
G
I
V
R
D
R
M
I
A
N
T
S
E
E
E
F
D
A
V
I
A
V
H
L
K
G
H
F
A
T
M
R
H
A
A
A
Y
W
R
G
L
S
K
A
G
K
A
---
V
D
G
R
---
I
I
N
T
S
S
G
A
G
L
Q
G
------
S
V
G
Q
G
N
Y
S
A
A
K
A
G
I
A
T
L
T
L
V
G
A
A
E
M
G
R
Y
G
V
T
V
N
A
I
A
P
---------
S
-
A
R
-
T
R
M
T
----
E
T
V
F
A
E
----------------------------
F
D
A
M
A
---
P
-------
E
N
V
S
P
L
V
V
W
L
G
S
-
A
E
A
R
D
V
T
G
K
V
F
E
V
E
G
-
G
K
I
R
V
A
E
G
W
A
H
G
P
Q
I
D
K
G
A
R
W
D
P
A
E
L
G
P
V
V
A
D
L
L
G
K
A
R
P
P
V
P
V
Y
G
A
26
PsiBlast_CBE
74.18
46%
-77
- C2 -
4KZP
6
?
D:
[24-306]
---
L
S
G
K
V
A
V
V
T
G
A
A
A
G
L
G
R
A
E
A
I
G
L
A
K
A
G
A
T
V
V
V
N
D
I
A
G
A
L
E
G
S
-----------
D
V
L
D
E
I
A
A
A
G
S
K
G
V
A
V
A
G
D
I
S
Q
R
S
T
A
D
E
L
V
E
T
A
-
E
G
L
G
G
L
D
I
V
V
N
N
A
G
I
T
R
D
R
I
L
F
N
M
S
D
E
E
W
D
A
V
I
A
V
H
L
R
G
H
F
L
L
T
R
N
A
A
A
Y
W
R
S
K
A
K
A
G
D
G
T
--
V
Y
G
R
---
V
I
N
T
S
S
E
A
G
L
S
G
------
P
V
G
Q
P
N
Y
G
A
A
K
A
G
I
T
A
L
T
L
S
A
A
R
A
L
E
R
F
G
V
R
A
N
A
I
A
P
---------
R
-
A
R
-
T
A
M
T
----
A
G
V
F
G
D
A
---
P
----------------------
Q
M
D
P
L
S
---
T
-------
D
H
V
V
T
L
V
Q
F
L
A
A
-
P
A
S
E
G
V
N
G
Q
L
F
I
V
Y
G
P
S
V
T
L
V
A
A
P
T
A
E
K
Q
F
V
A
D
E
D
A
W
E
P
A
D
L
S
V
T
L
R
D
Y
F
A
D
R
D
P
-------
2
PsiBlast_PDB
73.73
46%
-78
- C2 -
4KZP
9
?
A:
[24-306]
---
L
S
G
K
V
A
V
V
T
G
A
A
A
G
L
G
R
A
E
A
I
G
L
A
K
A
G
A
T
V
V
V
N
D
I
A
G
A
L
E
G
S
-----------
D
V
L
D
E
I
A
A
A
G
S
K
G
V
A
V
A
G
D
I
S
Q
R
S
T
A
D
E
L
V
E
T
A
-
E
G
L
G
G
L
D
I
V
V
N
N
A
G
I
T
R
D
R
I
L
F
N
M
S
D
E
E
W
D
A
V
I
A
V
H
L
R
G
H
F
L
L
T
R
N
A
A
A
Y
W
R
S
K
A
K
A
G
D
G
T
--
V
Y
G
R
---
V
I
N
T
S
S
E
A
G
L
S
G
------
P
V
G
Q
P
N
Y
G
A
A
K
A
G
I
T
A
L
T
L
S
A
A
R
A
L
E
R
F
G
V
R
A
N
A
I
A
P
---------
R
-
A
R
-
T
A
M
T
----
A
G
V
F
G
D
A
---
P
------------
E
---
A
---
E
G
Q
M
D
P
L
S
---
T
-------
D
H
V
V
T
L
V
Q
F
L
A
A
-
P
A
S
E
G
V
N
G
Q
L
F
I
V
Y
G
P
S
V
T
L
V
A
A
P
T
A
E
K
Q
F
V
A
D
E
D
A
W
E
P
A
D
L
S
V
T
L
R
D
Y
F
A
D
R
D
P
-------
27
PsiBlast_CBE
73.71
46%
-79
- C2 -
4KZP
1
?
B:
[24-306]
---
L
S
G
K
V
A
V
V
T
G
A
A
A
G
L
G
R
A
E
A
I
G
L
A
K
A
G
A
T
V
V
V
N
D
I
A
G
A
L
E
G
S
-----------
D
V
L
D
E
I
A
A
A
G
S
K
G
V
A
V
A
G
D
I
S
Q
R
S
T
A
D
E
L
V
E
T
A
-
E
G
L
G
G
L
D
I
V
V
N
N
A
G
I
T
R
D
R
I
L
F
N
M
S
D
E
E
W
D
A
V
I
A
V
H
L
R
G
H
F
L
L
T
R
N
A
A
A
Y
W
R
S
K
A
K
A
G
D
G
T
--
V
Y
G
R
---
V
I
N
T
S
S
E
A
G
L
S
G
------
P
V
G
Q
P
N
Y
G
A
A
K
A
G
I
T
A
L
T
L
S
A
A
R
A
L
E
R
F
G
V
R
A
N
A
I
A
P
---------
R
-
A
R
-
T
A
M
T
----
A
G
V
F
-----------------------------
Q
M
D
P
L
S
---
T
-------
D
H
V
V
T
L
V
Q
F
L
A
A
-
P
A
S
E
G
V
N
G
Q
L
F
I
V
Y
G
P
S
V
T
L
V
A
A
P
T
A
E
K
Q
F
V
A
D
E
D
A
W
E
P
A
D
L
S
V
T
L
R
D
Y
F
A
D
R
D
P
-------
30
PsiBlast_CBE
71.91
44%
-80
- C2 -
1ZBQ
1
DHB4_HUMAN
D:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
31
PsiBlast_CBE
71.89
44%
-81
- C2 -
1ZBQ
1
DHB4_HUMAN
C:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
29
PsiBlast_CBE
71.85
44%
-80
- C2 -
1ZBQ
1
DHB4_HUMAN
E:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
32
PsiBlast_CBE
71.27
44%
-82
- C2 -
1ZBQ
1
DHB4_HUMAN
B:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
28
PsiBlast_CBE
70.98
44%
-82
- C2 -
1ZBQ
1
DHB4_HUMAN
F:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
110
HHSearch
69.94
30%
-72
- C2 -
3PXX
1
?
A:
[6-286]
-
G
R
V
Q
D
K
V
V
L
V
T
G
G
A
R
G
Q
G
R
S
H
A
V
K
L
A
E
E
G
A
D
I
I
L
F
D
I
C
H
D
I
E
T
N
E
Y
P
LA
T
S
R
D
L
E
E
A
G
L
E
V
E
K
T
G
R
K
A
Y
T
A
E
V
D
V
R
D
R
A
A
V
S
R
E
L
A
N
A
V
A
E
F
G
K
L
D
V
V
V
A
N
A
G
I
C
P
L
G
A
--
H
L
P
V
Q
A
F
A
D
A
F
D
V
D
F
V
G
V
I
N
T
V
H
A
A
L
P
Y
L
T
S
-----------
G
A
S
---
I
I
T
T
G
S
V
A
G
L
I
A
A
A
QPPQ
G
P
G
G
A
G
Y
S
Y
A
K
Q
L
V
D
S
Y
T
L
Q
L
A
A
Q
L
A
P
Q
S
I
R
A
N
V
I
H
P
---------
T
-
N
V
N
T
D
M
L
----
N
S
A
P
M
Y
R
Q
F
R
P
DLEAPS
R
A
D
A
L
L
A
F
--
P
AMQ
A
M
P
T
P
Y
V
E
---
A
-------
S
D
I
S
N
A
V
C
F
L
A
S
-
D
E
S
R
Y
V
T
G
L
Q
F
K
V
D
A
-
G
A
M
L
K
-----------------------------------------
4
PsiBlast_PDB
69.87
45%
-77
- C2 -
1GZ6
3
DHB4_RAT
A:
[8-244]
----
D
G
R
V
V
L
V
T
G
A
G
G
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
S
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
A
G
E
K
L
V
K
T
A
L
D
T
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
S
R
I
S
D
E
D
W
D
I
I
Q
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
D
H
---------
M
K
K
Q
N
Y
G
R
---
I
I
M
T
A
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
T
L
V
I
E
G
R
K
N
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
E
T
V
---------------------
M
--
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
5
PsiBlast_PDB
69.78
44%
-81
- C2 -
1ZBQ
1
DHB4_HUMAN
A:
[28-265]
---
F
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
R
A
Y
A
L
A
F
A
E
R
G
A
L
V
V
V
N
D
L
G
G
D
F
K
G
V
-
G
K
--
G
S
L
A
A
D
K
V
V
E
E
I
R
R
R
G
G
K
A
V
A
N
Y
D
S
V
---
E
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
I
D
V
V
V
N
N
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
W
E
H
M
K
---------
K
Q
K
Y
G
R
---
I
I
M
T
S
S
A
S
G
I
Y
G
------
N
F
G
Q
A
N
Y
S
A
A
K
L
G
L
L
G
L
A
N
S
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
A
P
---------
N
-
A
G
-
S
R
M
T
----
Q
T
V
M
-----------------------
P
---
E
D
L
V
E
A
L
K
---
P
-------
E
Y
V
A
P
L
V
L
W
L
-
C
-
H
E
S
C
E
E
N
G
G
L
F
E
V
G
A
-
G
W
I
-------------------------------------------
7
PsiBlast_PDB
66.80
36%
-74
- C2 -
2UVD
-
?
A:
[1-245]
--
M
L
K
G
K
V
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
I
D
L
A
K
Q
G
A
N
V
V
V
N
---------
Y
A
G
--
N
E
Q
K
A
N
E
V
V
D
E
I
K
K
L
G
S
D
A
I
A
V
R
A
D
V
A
N
A
E
D
V
T
N
M
V
K
Q
T
V
D
V
F
G
Q
V
D
I
L
V
N
N
A
G
V
T
K
D
N
L
L
M
R
M
K
E
E
E
W
D
T
V
I
N
T
N
L
K
G
V
F
L
C
T
K
-
A
V
S
R
F
M
M
R
Q
R
H
G
--------
R
---
I
V
N
I
A
S
V
V
G
V
T
G
------
N
P
G
Q
A
N
Y
V
A
A
K
A
G
V
I
G
L
T
K
T
S
A
K
E
L
A
S
R
N
I
T
V
N
A
I
A
P
---------
G
F
I
A
-
T
D
M
T
DVLD
E
N
I
K
A
E
M
---
L
------------
K
L
I-
P
---
A
A
Q
F
G
--
E
---
A
-------
Q
D
I
A
N
A
V
T
F
F
A
S
-
D
Q
S
K
Y
I
T
G
Q
T
L
N
V
D
G
-
G
M
V
-------------------------------------------
38
PsiBlast_CBE
64.81
34%
-74
- C2 -
4JRO
1
?
B:
[27-270]
---
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
-----
Y
N
G
S
P
------
E
A
A
E
E
T
A
K
L
V
A
E
H
G
V
E
V
E
A
M
K
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
-
A
V
S
R
T
M
M
K
Q
R
A
G
K
-----------
I
I
N
M
A
S
V
V
G
L
I
G
------
N
A
G
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
---------
G
F
I
T
-
T
D
-------------------------------------
K
E
A
M
L
A
Q
I
---
P
LGAYGTT
E
D
I
A
N
A
V
L
F
L
A
S
-
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
-
G
M
V
-------------------------------------------
97
PsiBlast_CBE
61.14
38%
-74
* C2 *
4DMM
1
?
C:
[29-267]
------
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
---------
Y
A
S
--
S
A
G
A
A
D
E
V
V
A
A
I
A
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
---------
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
------
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
---------
G
F
I
A
-
T
D
M
----------
E
K
---
L
------------
L
E
VI
P
---
L
G
R
Y
G
E
A
A
------------
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
-
G
L
V
-------------------------------------------
98
PsiBlast_CBE
59.87
38%
-73
- C2 -
4DMM
1
?
B:
[29-267]
------
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
---------
Y
A
S
--
S
A
G
A
A
D
E
V
V
A
A
I
A
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
---------
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
------
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
---------
G
F
I
A
-
T
D
M
T
----
S
---------
L
------------
L
E
VI
P
---
L
G
R
Y
G
E
A
A
------------
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
-
G
L
V
-------------------------------------------
96
PsiBlast_CBE
57.84
38%
-73
- C2 -
4DMM
1
?
D:
[29-267]
------
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
A
V
N
---------
Y
A
S
--
S
A
G
A
A
D
E
V
V
A
A
I
A
A
A
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
A
A
A
K
I
M
---------
L
K
Q
R
S
G
R
---
I
I
N
I
A
S
V
V
G
E
M
G
------
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
---------
G
F
I
A
-
T
-------------
K
---
L
------------
L
E
VI
P
---
L
G
R
Y
G
E
A
A
------------
E
V
A
G
V
V
R
F
L
A
A
D
P
A
A
A
Y
I
T
G
Q
V
I
N
I
D
G
-
G
L
V
-------------------------------------------
76
PsiBlast_CBE
56.09
32%
-75
- C2 -
4I08
6
FABG_VIBCH
A:
[10-251]
---
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
----------
G
T
A
T
--
S
E
S
G
A
Q
A
I
S
D
-
Y
L
G
D
N
G
K
G
M
A
--
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
---
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
------
R
---
I
I
N
V
G
S
V
V
G
T
M
G
------
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
---------
G
F
I
E
-
T
D
M
--------
N
D
E
Q
---
R
------------
T
A
--
T
---
L
A
Q
V
P
A
G
R
L
G
D
P
-------
R
E
I
A
S
A
V
A
F
L
A
S
-
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
-
G
M
Y
M
I
-----------------------------------------
17
PsiBlast_PDB
53.90
34%
-69
- C2 -
3OSU
15
FABG_STAAM
A:
[8-243]
---------
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
A
V
N
---------
Y
A
G
--
S
K
E
K
A
E
A
V
V
E
E
I
K
A
K
G
V
D
S
F
A
I
Q
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
S
L
D
V
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
------------
T
P
Q
M
L
R
Q
R
S
G
A
I
I
N
L
S
S
V
V
G
A
V
G
------
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
FIVSDMTD
A
-
L
S
-
D
E
L
K
----
E
Q
M
L
T
Q
I
P--
L
------------
A
R
--
F
---
G
Q
D
T
D
----------------
I
A
N
T
V
A
F
L
A
S
-
D
K
A
K
Y
I
T
G
Q
T
I
H
V
N
G
-
G
---------------------------------------------