@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0113: (2015-12-22 )
MATVIDRHSQPTWRDFLELTKPKVVVLMLITSLIGMLLATKAPLDGFVPWQVLIFGNLGIGLCAGAAAAVNHVVDRRIDSIMARTHKRPLAEGRVSPSMALGFALLLALAGMAVLLAFTNPLTAWLTLASLLGYAALYTGFLKRATPQNIVIGGLAGAAPPLLGWVAITGHLSAEPLLLVLIIFAWTPPHFWALCIHRKDEYAKADIPMLPVTHGERYTKLHILLYTLVLFAVSLMPFVIHMSGLVYLLCALALGARFLDWAWALYCDSRPHAAIKTFKYSIVYLFLLFMALLVDHYLPLKLLL
Atome Classification :
(20 SA)
-----------------------------------------------.....-....10.......-----------.20.-----......----------------.30........40........50--.........60.-.....----..70..------..-..---..80--........------90--------....-....-------100....-...110.-----......120...-....130-.--.----.....140..---------------.....150-..---.....160....-----...170-------------......----..-180..-------.---..-..------------------------.190---...--------.....--------.200..--..-.----..210..---.....220.....----.------------.-230....----...240--..-----.......250..-----.....260...-....270----------------.---.....----...280--....-.....-290..------------.....300..----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------MATVI-DRHSQP
T
W
R
D
F
L
E
-----------LTKP-----K
V
V
V
L
M
----------------
L
I
T
S
L
I
G
M
L
L
ATKAPLDGFV
P
W
---
Q
V
L
I
F
GNL
G
I
G
L
-CA
G
A
A
----
A
A
V
N
H
V
------
V
D
-
R
R
---
I
D
S
I
--
M
A
R
T
HKRP------LA--------EGRV-S
P
S
M
-------
A
L
G
F
A
L
L
-
L
A
L
A
G
M
A
-----
V
L
L
A
FT
N
P
L
T
A
W
-
L
T
L
A
S
L
L
-
G
--
Y
----
A
A
L
Y
T
G
F
L
KR---------------ATPQ
N
I
V
I
-GG---LAGAAPP
L
L
G
W
V
-----
A
I
TGH--------------LSAEP
L
----
L
L
-
V
-
L
I
I
-------
F
---AW-TP------------------------
P
H
-----
F
W
A
--------
L
C
I
HR--------KDEYAK--AD-I----
P
M
L
PVTH---GE
R
Y
T
K
L
H
I
L
L
Y
T
----
L
------------
V
-
L
F
A
V
S
L
M
----
P
F
V
I
----
H
M
-----
S
G
L
V
Y
L
L
C
A
L
A
L
-----
G
A
R
F
L
D
W
A
W
A
L
-
Y
CDSR------------------P---
H
A
A
I
K
----
T
F
K
Y
----
S
I
V
Y
-
L
F
L
L
F
-
M
A
L
L
V
------------DHYLPLKLLL----------------------------------------
25
Fugue
88.33
20%
-171
- C5 -
4Q05
2
?
A:
[34-360]
---------------------------EN
S
W
Q
I
G
P
R
T
L
P
APSGAS
D
V
L
Y
N
I
I
-
S
K
T
P
T
P
V
P
T
I
N
L
N
-----------
L
V
P
R
T
E
S
E
W
R
A
A
I
T
Q
----------------
L
D
E
G
K
V
D
M
A
R
E
I
S
K
Q
L
S
V
S
V
E
H
---
G
V
I
E
----
G
V
S
V
-
Y
Y
V
T
P
----
V
E
V
A
P
D
------
L
E
-------
D
K
L
--
F
V
H
T
H
G
G
A
------
F
V
--------
L
N
G
--
G
E
A
G
-------
T
I
E
A
I
V
I
-
A
T
L
A
K
V
R
-----
V
L
S
I
D
Y
R
M
P
P
S
H
-
P
A
P
A
A
R
D
-
D
--
V
----
F
T
V
Y
Q
H
L
L
K
Q
---------------
G
S
A
Q
K
I
A
L
-
G
G
---
S
S
G
G
A
N
L
T
M
G
L
V
-----
Q
---
H
--------------
L
I
E
Q
E
V
----
D
L
-
P
-
G
A
L
-------
F
---
L
G
-
T
P
GADMSKTG
D
S
Y
Y
I
N
DGIDRNLVTY
D
G
-----
F
L
E
--------
A
A
V
R
L
--------
Y
A
N
G
R
D
--
L
K
-
D
----
P
L
V
S
P
L
Y
---
G
D
L
H
G
F
P
P
T
F
L
I
T
G
TRD
L
------------
L
-
L
S
A
T
V
R
T
----
H
I
K
L
----
R
Q
-----
S
G
V
V
A
D
L
F
V
Y
E
------
G
I
A
H
G
D
Y
A
V
D
L
-
T
A
-------------------------------------
P
----
E
T
Q
H
-
A
F
A
E
L
-
N
A
F
L
L
------------
Q
H
L
R
----------------------------------------------
23
Fugue
84.58
17%
-153
* C5 *
4TQ3
3
?
A:
[15-301]
-------------------------------------------------------------
S
K
Y
L
R
-----------
L
L
R
P
-----
V
A
W
L
C
F
----------------
L
L
P
Y
A
V
G
F
G
F
G
----
I
T
P
N
A
S
L
---
Q
H
A
V
L
G
L
L
S
F
A
F
-
W
M
A
F
S
----
F
T
I
N
A
L
------
Y
D
-
R
D
---
V
D
R
L
HD
G
L
N
L
S
M
Q
P
------
L
V
--------
T
G
E
I
-
S
V
R
E
-------
A
W
L
Y
C
I
A
-
F
L
A
L
S
L
A
-----
T
A
A
A
I
N
E
K
F
F
L
A
-
M
L
G
A
N
I
I
-
G
--
Y
----
V
Y
S
A
P
P
R
F
K
A
---------------
W
P
V
M
D
V
I
C
-
N
A
---
L
A
A
V
L
A
F
Y
A
G
L
S
------
I
G
G
A
EVP-----------
I
A
I
Y
P
A
----
A
F
-
F
-
L
A
A
-------
T
---
F
Y
-
I
P
------------------------
T
A
-----
V
-------------
S
D
--------
Y
E
F
D
K
K
--
A
G
-
L
----
K
N
T
P
V
F
F
---
G
P
E
R
A
L
K
S
--
L
Y
P
----
L
------------
S
-
A
I
T
V
I
L
W
----
A
Y
V
F
----
L
M
-----
A
E
R
I
E
I
K
V
I
S
P
L
-----
I
I
A
Y
T
L
I
Y
T
F
I
-
I
N
S
R
W
------------------
D
---
G
E
K
L
N
----
V
S
P
N
----
L
I
L
T
-
P
F
G
I
I
-
S
A
L
F
I
------------
A
Y
G
F
A
V
I
S
V
-----------------------------------------
22
Fugue
84.48
19%
-143
- C5 -
4OD4
-
?
A:
[22-296]
-----------------------------------------------------------------------------
L
V
R
I
-----
E
H
T
I
F
S
----------------
L
P
F
A
Y
V
G
A
L
L
S
R
Y
P
F
-----
T
L
---
A
D
A
I
L
M
A
A
A
V
V
G
-
L
R
M
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
L
R
E
-------
A
W
A
L
V
A
A
-
G
S
A
I
Y
F
A
-----
S
A
A
L
L
N
---
T
Y
A
-
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
EASS
L
G
E
V
------
L
R
S
V
P
W
----
L
Y
-
V
-
A
A
V
-------
S
---
L
W
-
V
A
------------------------
G
F
-----
D
T
I
--------
Y
S
I
M
D
--------
I
D
F
D
R
S
--
H
G
-
L
----
G
S
I
P
A
L
L
---
G
P
K
G
A
L
A
A
S
L
A
M
H
----
A
------------
A
-
A
V
A
L
F
I
A
----
G
V
E
A
----
Y
G
-----
L
G
A
I
A
T
V
S
T
A
L
T
-----
A
L
V
I
I
L
V
Q
A
M
A
-
W
L
G
R
V
------------------
K
---
E
S
F
N
L
----
N
L
A
V
----
P
I
I
I
-
G
A
G
I
I
-
V
D
M
L
---------------------------------------------------------------
26
Fugue
76.28
20%
-122
* C4 *
4C2E
-
CTPB_BACSU
A:
[2-436]
AD
S
E
R
D
K
A
M
D
K
I
E
K
A
Y
E
L
I
S
N
EYVEKVD
R
E
K
L
L
E
G
A
I
Q
G
M
L
S
T
L
NDP
Y
S
V
Y
M
-
D
K
Q
T
A
K
Q
F
S
D
S
L
D
S
SFEGIG
A
E
V
G
M
E
D
G
-----
K
I
I
I
V
S
PFKKS
P
A
E
K
A
GLKPND
E
I
I
S
I
N
G
E
S
M
A
G
K
D
L
N
H
A
V
L
K
I
---
R
G
K
K
G
S
S
V
S
M
K
I
Q
R
P
G
T
K
----
K
Q
L
S
F
R
------
I
K
-
R
A
E
IP
L
E
T
V
--
F
A
S
E
K
K
V
Q
G
H
S
V
G
Y
I
A
--------
I
S
T
F
-
S
E
H
T
-------
T
E
D
F
A
K
A
-
L
R
E
L
E
K
K
EIE
G
L
V
I
D
V
R
G
N
P
G
G
Y
I
-
Q
S
V
E
E
I
L
-
K
--
H
FVTK
D
Q
P
Y
I
Q
I
A
E
R
NG
D
K
K
R
Y
F
S
TLTHKK
A
Y
P
V
N
V
I
T
D
K
G
---
S
A
A
A
S
E
I
L
A
G
A
L
-----
K
E
A
G
H
Y
D
V
V
G
DTSFGKG
T
V
Q
Q
A
V
P
M
GDG
S
N
I
-
K
-
L
T
L
-------
Y
---
K
W
L
T
P
------------------------
N
G
-----
N
W
I
HKKGIEPT
I
A
I
K
Q
--------
P
D
Y
F
S
A
--
G
P
-
L
Q
L
K
E
P
L
K
V
D
M
N
---
N
E
D
V
K
H
A
Q
V
L
L
K
G
----
L
SFDPGREDGYFS
K
-
D
M
K
K
A
V
M
----
A
F
Q
D
Q
N
KL
N
K
-----
T
G
I
I
D
T
R
T
A
E
T
L
-----
N
Q
Q
I
E
K
K
K
S
D
E
-
K
N
D
L
Q
------------------
L
---
Q
T
A
L
K
----
S
L
F
V
----------------------------------------------------------------------------------
31
Fugue
75.59
23%
-149
- C3 -
4QT9
2
?
A:
[19-432]
----------------------------------------------L
S
D
D
A
L
M
D
T
V
Q
R
R
T
F
L
Y
F
W
E
-----------
G
A
E
P
-----
N
---------------------------
S
G
L
A
P
E
R
Y
H
V
D
G
V
Y
P
Q
NDA
N
V
V
T
S
G
G
S
G
F
G
I
M
A
I
L
A
G
----
I
D
R
G
Y
V
T
R
E
E
G
L
A
R
M
E
R
---
I
V
S
F
--
L
E
K
A
D
R
F
H
------
G
A
YPHWWYGD
T
G
K
V
-
K
P
F
G
QKDNGGD
L
V
E
T
A
F
L
M
Q
G
L
L
A
V
H
-----
Q
Y
Y
A
N
G
N
---------
D
K
E
K
-
A
--
I
----
A
Q
R
I
D
R
L
W
R
E
---------------
V
D
W
D
W
Y
R
K
-
G
G
QNV
L
Y
W
H
W
S
P
T
Y
G
W
E
M----
D
F
P
I
H
--------------
G
Y
N
E
-------
C
M
I
M
Y
I
L
-------
A
---
A
A
-
S
P
------------------------
T
H
G----
V
P
A
--------
A
V
Y
H
D
G
W
AQNGAI
V
S
P
H
K
V
--
E
G
-
I
----
E
L
H
L
R
Y
Q
---
G
T
E
A
G
P
L
F
W
A
Q
Y
S
----
F
------------
L
G
L
D
P
V
G
L
K
DEYC
P
S
Y
F
----
H
E
M
----
R
N
L
T
L
V
N
R
A
Y
C
I
R
NPKH
Y
K
G
F
G
P
D
C
W
G
L
T
A
S
Y
S
V
DGYAAHSPNEQDDKGVIS
P
---
T
A
A
L
S
SIVY
T
P
E
Y
----
S
L
Q
V
M
R
H
L
Y
N
M
G
D
K
V
F
GPFGFYDAFSET
D
N
W
Y
P
Q
R
Y
L
A
I
D
Q
G
P
I
A
V
M
I
E
N
Y
R
TG
L
L
W
K
L
F
M
S
H
P
D
V
Q
A
G
L
T
K
L
GFNTN
29
Fugue
71.13
17%
-138
- C5 -
3OPY
2
PFKA3_PICPA
I:
[5-351]
--------------------------------------------DSI
I
R
D
L
E
-
R
E
N
V
G
P
E
F
G
E
F
L
N
-----------
T
L
Q
T
-----
D
L
----------------------
N
S
E
K
P
P
I
E
Q
V
K
S
Q
L
E
T
H
F
-----------
N
L
A
H
E
T
-
Q
E
F
S
R
KNDN
A
P
V
D
K
L
------
L
T
-
N
Y
---
Y
N
N
Y
--
E
V
N
V
L
E
F
V
------
L
Q
--------
M
G
F
S
R
D
L
S
I
-------
P
L
N
V
W
F
V
-
L
D
M
I
S
Q
L
-----
S
T
S
K
Q
D
L
P
L
D
Y
Y
-
L
V
L
N
N
S
Q
-
T
GK
Y
----
S
D
F
V
R
Y
L
I
Y
E
---------------
A
V
G
A
E
I
H
L
-
A
N
-------
R
G
P
I
R
G
N
V
GAGDR
K
I
T
F
H
--------------
L
L
C
K
K
T
----
A
R
-
M
-
I
L
V
GDDRETD
F
---
E
M
-
S
D
------------------------
R
S
-----
F
V
T
--------
L
L
L
D
Y
--------
Y
Q
R
V
G
T
--
T
K
K
I
----
D
L
L
L
L
T
N
NFD
T
N
M
N
N
K
L
Q
Q
L
K
I
L
----
E
------------
S
-
L
N
M
L
K
S
N
----
C
Y
V
L
----
D
Y
QITVD
Q
V
T
A
N
F
N
S
Y
V
E
G
-----
I
P
A
F
R
R
H
E
I
A
N
-
F
L
K
K
R
------------------
K
TPK
N
A
D
E
L
----
I
F
K
Y
VGRW
N
I
C
Y
-
Q
K
K
F
H
-
Q
G
N
I
S
------------
I
H
Q
I
S
G
Y
L
D
-----------------------------------------
27
Fugue
55.41
12%
-140
- C4 -
4D10
1
CSN5_HUMAN
E:
[24-333]
-----------------------------------------------
S
I
D
E
I
-
Y
K
Y
D
K
K
Q
Q
Q
E
I
L
A
A
KPW-------
T
K
D
H
-----
H
Y
F
K
Y
C
----------------
K
I
S
A
L
A
L
L
K
M
V
M
H
A
R
S
G
G
N
L
E
V
---
M
G
L
M
L
G
K
V
D
------
G
E
T
----
M
I
I
M
D
S
------
F
A
-
L
P
---
V
E
G
T
--
E
T
R
V
N
--------------------------
A
Q
-------
A
A
A
Y
E
Y
M
-
A
A
Y
I
E
N
A
-----
K
Q
V
G
R
L
E
N
A
I
G
W
-
Y
H
--
S
H
P
-
G
--
Y
----
G
C
W
L
S
G
I
D
V
S
---------------
T
Q
M
L
N
Q
Q
F
-
Q
--------
E
P
F
V
A
V
V
I
-----
D
P
T
R
T
--------------
I
S
A
G
K
V
----
N
L
-
G
-
A
F
R
-------
T
Y
P
K
G
Y
-
K
P
------------------------
P
D
EGPSE
Y
Q
T
--------
I
P
L
N
K
--------
I
E
D
F
G
V
H
C
K
Q
-
Y
----
Y
A
L
E
V
S
Y
---
F
K
S
S
L
D
R
K
L
L
E
L
L
----
W
------------
N
-
K
Y
W
V
N
T
L
----
S
S
S
S
----
L
L
-----
T
N
A
D
Y
T
T
G
Q
V
F
D
-----
L
S
E
K
L
E
Q
S
E
A
Q
-
L
G
R
G
S
------------------
E
---
D
K
L
A
K
----
A
T
R
D
----
S
C
K
T
-
T
I
E
A
I
-
H
G
L
M
S
------------
Q
V
I
K
D
K
L
F
N
Q
INI-------------------------------------
1
PsiBlast_PDB
54.43
37%
-97
- C6 -
4OD4
-
?
A:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
M
L
-------------------------------------------
7
PsiBlast_CBE
53.70
37%
-96
- C6 -
4OD5
3
?
F:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
2
PsiBlast_PDB
53.37
37%
-96
- C6 -
4OD5
3
?
A:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
8
PsiBlast_CBE
53.36
37%
-96
- C6 -
4OD5
4
?
E:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
9
PsiBlast_CBE
53.33
37%
-96
- C6 -
4OD5
3
?
D:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
11
PsiBlast_CBE
53.30
37%
-96
- C6 -
4OD5
3
?
B:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
10
PsiBlast_CBE
53.08
37%
-96
- C6 -
4OD5
4
?
C:
[64-142]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
G
----
M
A
Y
N
N
I
------
A
D
-
L
D
---
I
D
R
L
--
N
P
R
T
A
K
R
P
------
L
V
--------
V
G
A
V
-
S
-----------
L
R
E
A
W
A
-
L
V
A
A
G
S
A
-----
I
Y
F
A
S
A
A
L
L
N
T
Y
A
L
L
L
S
P
L
V
-
L
--
A
----
I
A
L
T
Y
P
H
A
K
R
---------------
L
H
P
L
P
H
L
H
-
L
G
---
I
V
L
G
S
V
V
F
G
G
A
V
-----
A
A
S
G
D
--------------
E
A
S
S
L
G
----
E
V
-
L
-
R
S
V
-------
P
---
W
L
-
Y
V
------------------------
A
A
-----
V
S
L
--------
W
V
A
G
F
--------
D
T
I
Y
S
I
--
M
D
-
I
----
D
F
D
R
S
H
G
---
L
G
S
I
P
A
L
L
G
P
K
G
A
----
L
------------
A
-
A
S
L
A
M
H
A
----
A
A
V
A
----
L
F
-----
I
A
G
V
E
A
Y
G
L
G
A
I
-----
A
T
V
S
T
A
L
T
A
L
V
-
I
I
L
V
Q
------------------
A
---
M
A
W
L
G
----
R
V
K
E
----
S
F
N
L
-
N
L
A
V
P
-
I
I
I
G
A
------------
G
I
I
V
D
---------------------------------------------
5
PsiBlast_PDB
39.76
30%
-109
- C6 -
4HUM
-
?
A:
[99-171]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
L
I
-
L
G
I
F
G
M
I
-----
L
M
W
A
A
I
T
P
F
R
N
W
-
L
T
L
S
D
Y
V
E
G
--
T
----
M
A
Q
Y
M
L
F
T
S
L
---------------
A
M
P
A
A
M
V
H
-
R
A
---
L
H
A
Y
A
S
S
L
------------------------------
N
R
P
R
----
L
I
-
M
-
L
V
S
-------
F
---
A
A
-
F
V
------------------------
L
N
-----
V
P
L
--------
N
Y
I
F
V
--------
Y
G
K
F
G
M
--
P
A
-
L
----
G
G
A
G
C
G
V
---
A
T
M
A
V
F
W
F
S
A
L
A
L
----
W
------------
I
-
Y
I
A
K
E
K
F
----
F
R
P
F
----
G
L
-----
T
A
K
F
G
K
P
D
W
A
V
F
-----
K
Q
I
W
K
I
G
A
P
I
G
-
L
S
Y
F
L
------------------
E
---
A
S
A
F
S
----
F
I
V
F
----
L
I
A
P
-
F
G
E
D
Y
-
V
A
A
Q
Q
------------
V
G
I
S
L
S
G
I
L
Y
----------------------------------------
6
PsiBlast_PDB
38.97
30%
-100
- C6 -
4HUN
1
?
A:
[99-171]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
L
I
-
L
G
I
F
G
M
I
-----
L
M
W
A
A
I
T
P
F
R
N
W
-
L
T
L
S
D
Y
V
E
G
--
T
----
M
A
Q
Y
M
L
F
T
S
L
---------------
A
M
P
A
A
M
V
H
-
R
A
---
L
H
A
Y
A
S
S
L
------------------------------
N
R
P
R
----
L
I
-
M
-
L
V
S
-------
F
---
A
A
-
F
V
------------------------
L
N
-----
V
P
L
--------
N
Y
I
F
V
--------
Y
G
K
F
G
M
--
P
A
-
L
----
G
G
A
G
C
G
V
---
A
T
M
A
V
F
W
F
S
A
L
A
L
----
W
------------
I
-
Y
I
A
K
E
K
F
----
F
R
P
F
----
G
L
-----
T
A
K
F
G
K
P
D
W
A
V
F
-----
K
Q
I
W
K
I
G
A
P
I
G
-
L
S
Y
F
L
------------------
E
---
A
S
A
F
S
----
F
I
V
F
----
L
I
A
P
-
F
G
E
D
Y
-
V
A
A
Q
Q
------------
V
G
I
S
L
S
G
I
L
Y
----------------------------------------
3
PsiBlast_PDB
38.57
30%
-103
- C6 -
4HUK
-
?
A:
[99-171]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
L
I
-
L
G
I
F
G
M
I
-----
L
M
W
A
A
I
T
P
F
R
N
W
-
L
T
L
S
D
Y
V
E
G
--
T
----
M
A
Q
Y
M
L
F
T
S
L
---------------
A
M
P
A
A
M
V
H
-
R
A
---
L
H
A
Y
A
S
S
L
------------------------------
N
R
P
R
----
L
I
-
M
-
L
V
S
-------
F
---
A
A
-
F
V
------------------------
L
N
-----
V
P
L
--------
N
Y
I
F
V
--------
Y
G
K
F
G
M
--
P
A
-
L
----
G
G
A
G
C
G
V
---
A
T
M
A
V
F
W
F
S
A
L
A
L
----
W
------------
I
-
Y
I
A
K
E
K
F
----
F
R
P
F
----
G
L
-----
T
A
K
F
G
K
P
D
W
A
V
F
-----
K
Q
I
W
K
I
G
A
P
I
G
-
L
S
Y
F
L
------------------
E
---
A
S
A
F
S
----
F
I
V
F
----
L
I
A
P
-
F
G
E
D
Y
-
V
A
A
Q
Q
------------
V
G
I
S
L
S
G
I
L
Y
----------------------------------------
21
HHSearch
38.49
11%
-40
- C6 -
3LOM
1
?
A:
[72-125]
---------------------------------------------------------------------------------------------------------------------------------------
L
D
I
I
A
A
A
L
E
L
-
T
H
C
Y
S
----
L
I
H
D
D
L
------
P
A
-
M
D
---
N
D
D
L
---
R
R
--
G
K
P
------
S
C
--------
H
K
A
F
-
D
E
A
T
-------
A
I
L
V
G
D
G
-
M
Q
A
L
A
I
E
-----
V
L
L
M
R
L
S
P
L
L
P
A
-
A
Q
V
V
A
I
T
-
Q
--
V
----
L
V
N
A
S
G
I
S
G
M
---------------
V
S
G
Q
S
L
D
L
-
S
E
---
L
A
K
S
S
V
T
E
E
Q
L
R
-----
E
I
H
L
L
--------------
K
T
G
K
L
I
----
L
A
-
C
-
F
E
M
-------
V
---
L
A
-
A
Q
------------------------
H
E
-----
V
S
E
--------
Q
I
K
S
A
--------
L
R
T
Y
G
K
--
H
I
-
G
----
L
V
F
Q
M
Q
D
---
D
Y
L
D
L
Y
A
P
K
T
T
F
A
----
T
------------
L
-
F
N
K
Q
Q
L
E
----
E
E
I
A
----
V
H
-----
Y
Q
I
A
M
D
S
L
R
L
F
G
-----
S
K
A
A
A
L
I
E
L
T
K
-
Q
L
Q
N
R
------------------
S
---
N
L
S
E
-------------------------------------------------------------------------------------------
4
PsiBlast_PDB
38.40
30%
-101
- C6 -
4HUL
-
?
A:
[99-171]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
L
I
-
L
G
I
F
G
M
I
-----
L
M
W
A
A
I
T
P
F
R
N
W
-
L
T
L
S
D
Y
V
E
G
--
T
----
M
A
Q
Y
M
L
F
T
S
L
---------------
A
M
P
A
A
M
V
H
-
R
A
---
L
H
A
Y
A
S
S
L
------------------------------
N
R
P
R
----
L
I
-
M
-
L
V
S
-------
F
---
A
A
-
F
V
------------------------
L
N
-----
V
P
L
--------
N
Y
I
F
V
--------
Y
G
K
F
G
M
--
P
A
-
L
----
G
G
A
G
C
G
V
---
A
T
M
A
V
F
W
F
S
A
L
A
L
----
W
------------
I
-
Y
I
A
K
E
K
F
----
F
R
P
F
----
G
L
-----
T
A
K
F
G
K
P
D
W
A
V
F
-----
K
Q
I
W
K
I
G
A
P
I
G
-
L
S
Y
F
L
------------------
E
---
A
S
A
F
S
----
F
I
V
F
----
L
I
A
P
-
F
G
E
D
Y
-
V
A
A
Q
Q
------------
V
G
I
S
L
S
G
I
L
Y
----------------------------------------
20
HHSearch
36.57
9%
-39
- C6 -
2H8O
-
?
A:
[107-159]
---------------------------------------------------------------------------------------------------------------------------------------
G
L
H
V
G
A
A
L
E
C
-
L
H
C
Y
S
----
L
V
H
D
D
L
------
P
A
-
M
D
---
D
D
D
L
---
R
R
--
G
Q
P
------
T
V
--------
H
R
K
F
-
D
E
A
T
-------
A
I
L
A
G
D
S
-
L
L
T
L
A
F
D
-----
I
I
A
S
D
D
N
P
L
A
A
E
-
R
K
A
A
L
V
I
-
S
--
L
----
A
R
A
A
G
I
G
G
M
A
---------------
G
G
Q
A
L
D
L
A
-
A
E
---
K
K
A
P
D
E
D
G
I
I
T
L
-----
Q
A
M
K
T
--------------
G
A
L
L
R
F
----
A
C
-
E
-
A
G
A
-------
I
---
I
A
-
G
S
------------------------
N
Q
-----
A
E
R
--------
Q
R
L
R
L
--------
F
G
E
K
I
G
--
L
S
-
F
----
Q
L
A
D
D
L
L
---
D
L
T
K
G
T
L
V
A
L
R
G
E
----
A
------------
W
-
A
R
E
K
L
Q
E
----
Q
V
A
E
----
A
S
-----
E
L
L
A
P
Y
G
E
K
A
A
I
-----
L
I
A
A
A
R
F
I
A
E
----------------------------------------------------------------------------------------------------------------------------