@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3774: (2016-02-20 )
MTRRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKSLLDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQDAPIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAMGFCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSISLHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVLPALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHAGGRLVVVHEGGYSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNAAFRDFQRQRLEELAAQFGLCPAQPLQAAR
Atome Classification :
(52 SA)
.........10........20......-..30...-.....40........50.---.......60........70........80..--------......90--.--..-.----------------.-.-..100..-----.-..-----------..110.......120.......130.......140.......150.......160.......170.......180.......190.......200...--.--.---..210.......220.......230----..----.....240.......250.......260.......270....--.....280.......290.......300.......310.......320.......330.......340.......350........360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTR
R
T
A
F
F
F
D
E
L
C
L
WHAAGP
H
A
L
T
LPV-GGWVQPP-AAAGHAES
P
E
T
K
R
R
L
K
S
L
---
L
D
VSG
L
T
A
R
L
Q
LRSAPPASD
E
D
L
LRV
H
P
A
H
Y
--------
L
E
R
F
K
A
L
S--D--AG-G----------------G-S-LGQDAPI-----G-PG-----------S
Y
E
I
A
R
L
SA
G
L
A
I
A
A
L
D
A
V
LAGEADNAYSLSRPPGHHCL
P
D
Q
A
M
G
F
C
F
F
A
N
I
A
V
A
I
E
A
A
K
ARHGV
E
R
V
A
V
L
D
W
D
VHHGNG
T
Q
A
I
Y
Y
RRD
D
V
L
S
I
S
LHQ--D--G---CFPPGYS
G
A
E
D
I
GEDRGRGFNLNVP----LL----PGGG
H
D
A
Y
M
Q
A
M
Q
R
I
V
L
P
A
L
E
RFRP
Q
L
I
V
V
ASGFDA--NAV
D
--
P
L
A
R
M
QLHS
D
S
F
R
A
M
T
A
M
V
R
D
A
A
E
RHAG
G
R
L
V
V
V
HEGGYSEA
Y
V
PF
C
G
L
A
V
I
E
E
L
S
G
V
R
S
A
V
R
D
P
L
R
D
F
I
E
LQQP
N
A
-
A
F
R
D
F
Q
R
Q
R
L
E
E
L
A
A
QFGLCPAQPLQAAR
115
HHSearch
98.46
45%
-100
- C6 -
1ZZ1
5
HDAH_ALCSD
A:
[2-367]
---
A
I
G
Y
V
W
N
T
L
Y
G
W
V
D
T
G
T
G
S
L
A
A
A
N
L
T
A
R
M
Q
P
I
S
H
---
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
--
L
P
-
T
G---------------
G
-
D
T
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
-
G
G
N
-
T
L
L
D
A
E
R
A
A
I
E
E
I
V
P
L
L
A
D
----------
26
PsiBlast_CBE
96.92
49%
-98
- C6 -
2GH6
5
HDAH_ALCSD
B:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
35
PsiBlast_CBE
96.90
49%
-99
- C6 -
1ZZ0
4
HDAH_ALCSD
B:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
33
PsiBlast_CBE
96.86
49%
-99
- C6 -
1ZZ0
4
HDAH_ALCSD
D:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
31
PsiBlast_CBE
96.63
49%
-99
- C6 -
1ZZ1
5
HDAH_ALCSD
C:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
2
PsiBlast_PDB
96.63
49%
-99
- C6 -
1ZZ1
5
HDAH_ALCSD
A:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
1
PsiBlast_PDB
96.51
49%
-98
- C6 -
1ZZ0
4
HDAH_ALCSD
A:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
34
PsiBlast_CBE
96.45
49%
-101
- C6 -
1ZZ0
4
HDAH_ALCSD
C:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
25
PsiBlast_CBE
96.44
49%
-99
- C6 -
2GH6
5
HDAH_ALCSD
C:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
23
PsiBlast_CBE
96.39
49%
-102
- C6 -
2VCG
5
HDAH_ALCSD
B:
[42-367]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
29
PsiBlast_CBE
96.30
49%
-100
- C6 -
1ZZ3
5
HDAH_ALCSD
B:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
24
PsiBlast_CBE
96.18
49%
-98
- C6 -
2GH6
5
HDAH_ALCSD
D:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
21
PsiBlast_CBE
96.13
49%
-102
- C6 -
2VCG
8
HDAH_ALCSD
D:
[42-367]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
32
PsiBlast_CBE
96.12
49%
-100
- C6 -
1ZZ1
5
HDAH_ALCSD
B:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
5
PsiBlast_PDB
96.11
49%
-100
- C6 -
2VCG
5
HDAH_ALCSD
A:
[42-367]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
125
Fugue
96.03
44%
-94
- C6 -
1ZZ1
5
HDAH_ALCSD
A:
[2-368]
---
A
I
G
Y
V
W
N
T
L
Y
G
W
V
D
T
G
T
G
S
L
A
A
A
N
-
L
T
A
R
M
Q
P
-
I
S
-
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
N
L
P
--
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
L
-
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
D
A
E
R
A
A
I
E
E
I
V
P
L
L
A
D
I
----------
22
PsiBlast_CBE
96.00
49%
-100
- C6 -
2VCG
7
HDAH_ALCSD
C:
[42-367]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
27
PsiBlast_CBE
95.90
49%
-99
- C6 -
1ZZ3
5
HDAH_ALCSD
D:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
4
PsiBlast_PDB
95.80
49%
-98
- C6 -
2GH6
5
HDAH_ALCSD
A:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
30
PsiBlast_CBE
95.55
49%
-98
- C6 -
1ZZ1
5
HDAH_ALCSD
D:
[36-361]
----------------------------------------
H
L
A
H
P
D
T
K
R
R
F
H
E
L
---
V
C
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
A
T
D
A
D
I
L
R
A
H
S
A
A
H
--------
L
E
N
M
K
R
V
S
--
N
LP
T
G
-
G
----------------
D
-
T
-
G
D
G
I
T
M
M
-----
G
-
N
G
-----------
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
G
E
L
S
A
G
Y
A
L
V
N
P
P
G
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
L
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
Q
--
H
--
L
---
C
F
P
P
D
S
G
Y
S
T
E
R
G
A
G
N
G
H
G
Y
N
I
N
V
P
----
L
P
----
P
G
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V
L
P
A
L
R
A
Y
R
P
Q
L
I
I
V
G
S
G
F
D
A
--
S
M
L
D
--
P
L
A
R
M
M
V
T
A
D
G
F
R
Q
M
A
R
R
T
I
D
C
A
A
D
I
C
D
G
R
I
V
F
V
Q
E
G
G
Y
S
P
H
Y
L
P
F
C
G
L
A
V
I
E
E
L
T
G
V
R
S
-
L
P
D
P
Y
H
E
F
L
A
G
M
G
G
N
T
-
L
L
-
D
A
E
R
A
A
I
E
E
I
----------------
116
HHSearch
86.60
31%
-90
- C6 -
2VQM
5
A:
[7-385]
-
R
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
----------------------
H
A
G
R
I
Q
S
I
W
S
R
---
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
--------
T
L
L
Y
G
T
N
P
--
L
--
N
R
Q
K
K
L
L
G
S
L
A
S
V
F
VRLPCG
G
V
G
-
V
D
S
D
T
I
W
-----
N
E
V
H
-----------
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
--
Y
--
D
DGN
F
F
P
-
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
----
F
T
GGLD
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
--
V
E
G
H
PT
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
---
P
L
P
E
K
V
L
Q
Q
R
P
N
A
-
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
-----------
45
PsiBlast_CBE
80.47
31%
-91
- C6 -
3ZNS
5
HDAC7_HUMAN
B:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
YGTNP
L
S
R
L
K
L
D
N
--
G
--
K
L
-
A
----------------
G
-
L
-
L
A
Q
---
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
17
PsiBlast_PDB
80.47
31%
-97
- C6 -
3ZNR
5
HDAC7_HUMAN
A:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP
L
S
-----------------------------------------
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
16
PsiBlast_PDB
80.47
31%
-93
- C6 -
3C10
5
HDAC7_HUMAN
A:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP
L
S
R
L
K
L
D
N
--
G
--
K
L
-
A
----------------
G
-
L
-
L
A
Q
---
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
44
PsiBlast_CBE
80.19
31%
-98
- C6 -
3ZNS
5
C:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
NP--------------------------------------------LPCG-
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
15
PsiBlast_PDB
79.57
31%
-92
- C6 -
3C0Z
5
HDAC7_HUMAN
A:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP
L
S
R
L
K
L
D
N
--
G
--
K
L
-
A
----------------
G
-
L
-
L
A
Q
---
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
18
PsiBlast_PDB
79.39
31%
-96
- C6 -
3ZNS
5
HDAC7_HUMAN
A:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP
L
S
-----------------------------------------
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
50
PsiBlast_CBE
79.02
31%
-97
- C6 -
3C0Z
5
C:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP--------------------------------------------LPCG-
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
48
PsiBlast_CBE
78.98
31%
-99
- C6 -
3C10
5
C:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
GTNP--------------------------------------------LPCG-
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
51
PsiBlast_CBE
78.50
31%
-98
- C6 -
3C0Z
5
HDAC7_HUMAN
B:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
YGTNP
L
S
-----------------------------------------
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
49
PsiBlast_CBE
78.16
31%
-96
- C6 -
3C10
5
HDAC7_HUMAN
B:
[58-397]
----------------------------------------
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
YGTNP
L
S
-----------------------------------------
V
MLPCG
G
-
V
G
VDTDTIWNELH
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
HD
D
--
G
---
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
WAGG
L
D
----
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
--
A
E
G
H
PA
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
----
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
---
D
P
L
S
E
E
G
W
K
Q
K
P
N
-------------------------------
6
PsiBlast_PDB
77.39
35%
-105
- C6 -
2VQO
5
HDAC4_HUMAN
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
38
PsiBlast_CBE
77.32
34%
-108
- C6 -
2VQQ
5
B:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
43
PsiBlast_CBE
77.30
34%
-109
- C6 -
4CBT
2
HDAC4_HUMAN
B:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
-----
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
37
PsiBlast_CBE
77.13
35%
-106
- C6 -
2VQO
5
B:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
13
PsiBlast_PDB
76.61
34%
-110
- C6 -
4CBT
2
HDAC4_HUMAN
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
-------
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
9
PsiBlast_PDB
76.58
34%
-105
- C6 -
2VQQ
5
HDAC4_HUMAN
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
12
PsiBlast_PDB
76.43
34%
-107
- C6 -
2VQM
4
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
11
PsiBlast_PDB
76.21
34%
-106
- C6 -
2VQJ
6
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
7
PsiBlast_PDB
76.11
35%
-103
- C6 -
2VQV
6
HDAC4_HUMAN
A:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
42
PsiBlast_CBE
75.85
34%
-105
- C6 -
4CBT
2
C:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
--
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
YD
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---------
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
36
PsiBlast_CBE
75.73
35%
-104
- C6 -
2VQV
6
B:
[127-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
--
G
---
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
FTGG
L
D
----
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
VE
G
H
P
T
--
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
----
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
---
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
--
E
K
V
M
E
I
H
S
K
Y
W
R
C
---------
59
PsiBlast_CBE
73.67
37%
-102
- C6 -
4ZUO
6
?
B:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
61
PsiBlast_CBE
73.46
37%
-106
- C6 -
4ZUN
4
?
B:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
62
PsiBlast_CBE
73.44
37%
-103
- C6 -
4ZUN
5
?
A:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
58
PsiBlast_CBE
73.40
37%
-101
- C6 -
4ZUP
9
?
A:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
64
PsiBlast_CBE
73.32
37%
-104
- C6 -
4ZUM
7
?
A:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
55
PsiBlast_CBE
73.29
37%
-104
- C6 -
4ZUQ
7
?
B:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
60
PsiBlast_CBE
73.17
37%
-103
- C6 -
4ZUO
6
?
A:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
63
PsiBlast_CBE
72.86
37%
-103
- C6 -
4ZUM
5
?
B:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
56
PsiBlast_CBE
72.85
37%
-102
- C6 -
4ZUQ
6
?
A:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------
57
PsiBlast_CBE
72.74
37%
-102
- C6 -
4ZUP
6
?
B:
[117-339]
----------------------------------------------------------------------------------------------------------------------------------------
E
T
A
I
-----
S
-
P
G
-----------
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
G
H
-
K
A
A
F
S
L
C
R
P
P
G
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
G
--
D
PA
E
---
A
F
P
H
F
L
G
Y
A
E
E
T
G
K
G
A
G
A
G
T
T
A
N
Y
P
----
M
G
----
R
G
T
P
Y
S
V
W
G
E
A
L
T
D
-
S
L
K
R
I
A
A
F
G
A
E
A
I
V
V
S
L
G
V
D
T
--
F
E
Q
D
--
P
I
S
F
F
K
L
T
S
P
D
Y
I
T
M
G
R
T
I
-----
A
A
S
G
V
P
L
L
V
V
M
E
G
G
Y
G
---
V
P
E
I
G
L
N
V
A
N
V
L
K
G
V
-------------------------------------------------