@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3896: (2016-02-21 )
MKKNVFVFSRLAPEHLERLQCQFNVRVLEPKQGDIDAQYAAALPDTHGMIGVGRPLGARQLEQAKQLEVISSVSVGYDNYDLDYLNRRGIALTNTPDVLTETTADLGFALLISAARRVAELDAWVKAGNWKRTVDAPQFGTDVHGKKLGILGLGRIGAAIARRGRFGFGMQVLYHGNNRKPELEQELGARFLGFDELLGEADFVCVVVPLGAQTRQLIGARELGLMKPSAILVNVARGQVVDEAALVAALREKRILGAGLDVYEKEPLAESPLFALDNVVTLPHIGSATHETRRAMAERALQNFEAALRGERPLDLVNPQVWRRG
Atome Classification :
(33 SA)
.........10........20--.--.......30-........40........-50.-.-.......60....-.....70........80........90........100.......110.......120.......130--....----.--...--140.......150.......160.......170....-....-180...-...-.190.......200.......210.......220.......230.......240.......250.......260.......--------270--.....-.-..280.......290.......300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
N
V
F
V
F
SRL
A
P
E
H
L
E
R
L
Q
C
--
Q
--
F
N
V
R
V
LEPK-QGDID
A
Q
Y
A
AALPDTHGM-I-G-V-GRPL
G
A
R
Q
-
L
E
Q
A
-
K
Q
L
E
V
I
S
S
V
SVGYDNY
D
L
D
Y
LNRRGIALTNTP
D
V
L
T
E
T
T
A
D
L
G
F
A
L
L
I
S
A
A
R
R
V
A
E
L
D
A
W
V
KAGNWK---RTVD----A--PQF--GTDVHG
K
K
L
G
I
L
G
L
G
R
I
G
A
A
I
A
RRGRFGF
G
M
Q
-
V
L
Y
H-GNNR-K
P
E
L
E
Q
-
E
L
G
-
A
R
F
L
G
F
D
E
L
LGEA
D
F
V
C
V
V
VPLGA
Q
T
R
Q
L
I
G
A
R
ELGLMKP
S
A
I
L
V
N
VARGQ
V
V
D
E
A
A
L
V
A
A
L
R
E
KRILGAGLDVYEKEPLA--------E-S--P
L
F
A
L-D-
N
V
V
TLPHIGS
A
T
H
E
T
R
R
A
M
A
E
R
A
L
Q
N
F
E
A
A
LRGERPLDLV
N
P
Q
VWRRG
24
PsiBlast_CBE
93.45
44%
-112
- C1 -
2DBR
3
GYAR_PYRHO
D:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
26
PsiBlast_CBE
92.65
44%
-111
- C1 -
2DBR
3
GYAR_PYRHO
B:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
2
PsiBlast_PDB
92.44
44%
-112
- C1 -
2DBZ
3
GYAR_PYRHO
A:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
23
PsiBlast_CBE
92.17
44%
-110
- C1 -
2DBR
3
GYAR_PYRHO
E:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
21
PsiBlast_CBE
91.50
44%
-114
- C1 -
2DBZ
3
GYAR_PYRHO
B:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
25
PsiBlast_CBE
91.48
44%
-112
- C1 -
2DBR
4
GYAR_PYRHO
C:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
115
HHSearch
91.28
44%
-111
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[1-328]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
K
E
I
P
R
-
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
M
L
-
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
AWHP
K
--
W
F
L
--
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
I
K
I
-
22
PsiBlast_CBE
90.98
44%
-111
- C1 -
2DBR
3
GYAR_PYRHO
F:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
FL
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
1
PsiBlast_PDB
90.53
44%
-114
* C1 *
2DBR
3
GYAR_PYRHO
A:
[1-325]
M
K
P
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
--
E
--
F
E
V
E
V
W
G
D
E
-
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
-
V
-
T
-
M
L
S
E
R
I
D
K
E
V
-
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
131
HHSearch
88.71
44%
-120
- C1 -
2CUK
-
?
A:
[1-310]
--
M
R
V
L
V
T
R
T
L
P
G
K
A
L
D
R
L
R
E
R
-
G
--
L
E
V
E
V
H
R
G
L
-
F
L
P
K
-
A
E
L
L
K
R
V
E
G
A
V
G
L
-
I
-
P
T
V
-
E
D
R
I
D
A
E
V
-
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
---
A
W
H
P
----
E
--
L
L
L
--
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
-
A
F
G
M
R
-
V
V
Y
H
-
A
R
T
P
-
K
P
L
P
-------
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P-------
G
-
H
--
P
L
Y
A
L
-
P
-
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
--------
114
HHSearch
85.21
34%
-111
- C1 -
2D0I
-
?
A:
[1-324]
M
R
P
K
V
G
V
L
L
K
M
K
R
E
A
L
E
E
L
K
K
--
Y
A
D
V
E
I
I
L
Y
P
-----
S
G
-
E
E
L
K
G
V
I
G
R
F
D
G
I
-
I
-
V
S
P
-
T
T
K
I
T
R
E
V
-
L
E
N
A
-
E
R
L
K
V
I
S
C
H
S
A
G
Y
D
N
I
D
L
E
E
A
T
K
R
G
I
Y
V
T
K
V
S
G
L
L
S
E
A
V
A
E
F
T
V
G
L
I
I
N
L
M
R
K
I
H
Y
A
D
K
F
I
R
R
G
E
W
E
---
S
H
A
K
I
W
T
-
G
--
F
K
R
--
I
E
S
L
Y
G
K
K
V
G
I
L
G
M
G
A
I
G
K
A
I
A
R
R
L
I
-
P
F
G
V
K
-
L
Y
Y
W
-
S
R
H
R
-
K
V
N
V
E
K
-
E
L
K
-
A
R
Y
M
D
I
D
E
L
L
E
K
S
D
I
V
I
L
A
L
P
L
T
R
D
T
Y
H
I
I
N
E
E
R
V
K
K
L
E
-
G
K
Y
L
V
N
I
G
R
G
A
L
V
D
E
K
A
V
T
E
A
I
K
Q
G
K
L
K
G
Y
A
T
D
V
F
E
K
E
P
V
R
--------
E
-
H
--
E
L
F
K
Y
E
W
-
E
T
V
L
T
P
H
Y
A
G
L
A
L
E
A
Q
E
D
V
G
F
R
A
V
E
N
L
L
K
V
L
R
G
E
V
P
E
D
L
V
N
K
E
V
L
E
V
-
10
PsiBlast_PDB
85.06
34%
-112
- C1 -
2D0I
-
?
A:
[1-321]
M
R
P
K
V
G
V
L
L
K
M
K
R
E
A
L
E
E
L
K
K
--
Y
--
A
D
V
E
I
I
L
Y
P
-
S
G
E
---
E
L
K
G
V
I
G
R
F
D
G
I
-
I
-
V
-
S
-
P
T
T
K
I
T
R
E
V
L
E
N
A
-
E
R
L
K
V
I
S
C
H
S
A
G
Y
D
N
I
D
L
E
E
A
T
K
R
G
I
Y
V
T
K
V
S
G
L
L
S
E
A
V
A
E
F
T
V
G
L
I
I
N
L
M
R
K
I
H
Y
A
D
K
F
I
R
R
G
E
W
E
S
H
A
K
I
W
T
----
G
--
F
K
R
--
I
E
S
L
Y
G
K
K
V
G
I
L
G
M
G
A
I
G
K
A
I
A
R
R
-
L
I
P
F
G
V
K
-
L
Y
Y
W
-
S
R
H
R
-
K
V
N
V
E
K
-
E
L
K
-
A
R
Y
M
D
I
D
E
L
L
E
K
S
D
I
V
I
L
A
L
P
L
T
R
D
T
Y
H
I
I
N
E
E
R
V
K
K
L
E
-
G
K
Y
L
V
N
I
G
R
G
A
L
V
D
E
K
A
V
T
E
A
I
K
Q
G
K
L
K
G
Y
A
T
D
V
F
E
K
E
P
V
R
--------
E
-
H
--
E
L
F
K
Y
-
E
W
E
T
V
L
T
P
H
Y
A
G
L
A
L
E
A
Q
E
D
V
G
F
R
A
V
E
N
L
L
K
V
L
R
G
E
V
P
E
D
L
V
N
K
E
V
----
126
HHSearch
83.65
35%
-114
- C1 -
1WWK
1
?
A:
[4-307]
--
M
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
K
D
A
-
G
--
L
E
V
I
Y
E
E
Y
P
---
D
E
-
D
R
L
V
E
L
V
K
D
V
E
A
I
-
I
-
V
R
S
-
K
P
K
V
T
R
R
V
-
I
E
S
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
A
---
K
K
---------
E
A
M
--
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
-
A
L
G
M
N
-
I
L
L
Y
-
D
P
Y
P
-
N
E
E
R
A
K
-
E
V
N
-
G
K
F
V
D
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K-------
D
-
H
--
P
L
T
K
F
-
D
-
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
---------------
123
HHSearch
82.94
37%
-112
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-329]
-
L
M
K
V
F
V
T
R
R
I
P
A
E
G
R
V
A
L
A
R
AA
D
--
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
-
K
E
L
E
R
G
V
A
G
A
H
G
L
-
L
-
C
L
L
-
S
D
H
V
D
K
R
I
-
L
D
A
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
---
S
W
K
P
----
L
--
W
L
C
--
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
-
P
F
G
V
Q
-
R
F
L
Y
-
T
G
R
Q
-
P
R
P
E
E
A
A
E
F
Q
-
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T-------
N
-
H
--
P
L
L
T
L
-
K
-
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
P
M
P
S
E
L
K
-------
13
PsiBlast_PDB
81.95
47%
-121
- C1 -
2CUK
-
?
A:
[55-310]
----------------------------------------------------------------
I
D
A
E
V
-
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
---
A
W
H
P
----
E
--
L
L
L
--
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
-
L
A
F
G
M
R
-
V
V
Y
H
-
A
R
T
P
-
K
P
------
L
P
-
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
--------
P
G
H
--
P
L
Y
A
L
-
P
-
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
--------
14
PsiBlast_PDB
81.88
35%
-110
- C1 -
3DDN
1
SERA_MYCTU
A:
[6-313]
----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
--
Q
--
V
E
V
R
W
V
D
G
P
-
D
R
D
---
K
L
L
A
A
V
P
E
A
D
A
L
L
V
-
R
-
S
-
A
T
T
V
D
A
E
V
-
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
---
R
S
----------
S
F
S
-
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
-
I
A
A
F
G
A
Y
-
V
V
A
Y
-
D
P
Y
V
-
S
P
A
R
A
A
-
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
--------
D
-
S
--
P
L
F
E
L
-
A
-
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
-------
3
PsiBlast_PDB
81.46
50%
-111
- C1 -
2DBQ
7
GYAR_PYRHO
A:
[62-325]
----------------------------------------------------------------------
F
E
N
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
---
K
R
G
V
----
A
WH
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
N
M
R
-
I
L
Y
Y
-
S
R
T
R
-
K
E
E
V
E
R
-
E
L
N
-
A
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
--------
N
-
E
--
E
L
F
K
L
-
D
-
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
----
16
PsiBlast_PDB
81.32
35%
-111
- C1 -
3DC2
-
SERA_MYCTU
A:
[7-314]
----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
--
Q
--
V
E
V
R
W
V
D
G
P
-
D
R
D
---
K
L
L
A
A
V
P
E
A
D
A
L
L
V
-
R
-
S
-
A
T
T
V
D
A
E
V
-
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
---
R
S
----------
S
F
S
-
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
-
I
A
A
F
G
A
Y
-
V
V
A
Y
-
D
P
Y
V
-
S
P
A
R
A
A
-
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
--------
D
-
S
--
P
L
F
E
L
-
A
-
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
-------
57
PsiBlast_CBE
80.94
32%
-106
- C1 -
2G76
3
SERA_HUMAN
B:
[27-327]
--
R
K
V
L
I
S
D
S
L
D
P
C
C
R
K
I
L
Q
---
D
--
G
G
L
Q
V
V
E
-
K
-
Q
N
L
S
K
E
E
L
I
A
E
L
Q
D
C
E
G
L
-
I
V
R
-
S
-
A
T
K
V
T
A
D
V
-
I
N
A
A
-
E
K
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
N
G
N
S
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
D
G
K
W
E
---
R
-------
K
--
K
F
M
--
G
T
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
-
S
F
G
M
K
-
T
I
G
Y
-
D
P
I
I
-
S
P
E
V
S
A
-
S
F
G
-
V
Q
Q
L
P
L
E
E
I
W
P
L
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
P
R
--------
D
-
R
--
A
L
V
D
H
-
E
-
N
V
I
S
C
P
H
L
G
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
V
Q
F
V
D
M
V
-----------------
15
PsiBlast_PDB
80.76
35%
-112
- C1 -
1YGY
-
SERA_MYCTU
A:
[7-314]
----
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
--
Q
--
V
E
V
R
W
V
D
G
P
-
D
R
D
---
K
L
L
A
A
V
P
E
A
D
A
L
L
V
-
R
-
S
-
A
T
T
V
D
A
E
V
-
L
A
A
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
---
R
S
----------
S
F
S
-
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
-
I
A
A
F
G
A
Y
-
V
V
A
Y
-
D
P
Y
V
-
S
P
A
R
A
A
-
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
--------
D
-
S
--
P
L
F
E
L
-
A
-
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
-------
33
PsiBlast_CBE
80.68
47%
-115
- C1 -
2CUK
1
?
C:
[55-310]
----------------------------------------------------------------
I
D
A
E
V
-
M
D
R
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
---
A
W
H
P
----
E
--
L
L
L
--
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
-
L
A
F
G
M
R
-
V
V
Y
H
-
A
R
T
P
-
K
P
------
L
P
-
Y
P
F
L
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
--------
P
G
H
--
P
L
Y
A
L
-
P
-
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
--------
31
PsiBlast_CBE
77.85
43%
-121
- C1 -
2GCG
3
GRHPR_HUMAN
B:
[76-322]
----------------------------------------------------------------------------
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
---
S
W
K
P
----
L
--
W
L
C
--
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
-
P
F
G
V
Q
R
F
L
Y
T
-
G
R
Q
P
-
R
P
E
E
A
A
-
E
F
Q
-
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
--------
T
-
N
H-
P
L
L
T
L
-
K
-
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
--------------
30
PsiBlast_CBE
77.12
43%
-116
- C1 -
2GCG
4
GRHPR_HUMAN
C:
[76-322]
----------------------------------------------------------------------------
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
---
S
W
K
P
----
L
--
W
L
C
--
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
-
P
F
G
V
Q
R
F
L
Y
T
-
G
R
Q
P
-
R
P
E
E
A
A
-
E
F
Q
-
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
--------
T
-
N
H-
P
L
L
T
L
-
K
-
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
--------------
6
PsiBlast_PDB
76.07
43%
-123
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[76-322]
----------------------------------------------------------------------------
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
---
S
W
K
P
----
L
--
W
L
C
--
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
-
P
F
G
V
Q
R
F
L
Y
T
-
G
R
Q
P
-
R
P
E
E
A
A
-
E
F
Q
-
A
E
F
V
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
--------
T
-
N
H-
P
L
L
T
L
-
K
-
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
--------------
5
PsiBlast_PDB
73.28
38%
-101
- C1 -
3BAZ
1
HPPR_PLESU
A:
[52-328]
--------------------------------
Q
P
A
-
Q
R
D
F
L
A
L
Q
A
E
S
I
R
A
V
V
G
N
-
S
-
N
-
A
-
G
A
--
D
A
E
L
-
I
D
A
L
-
P
K
L
E
I
V
S
S
F
S
V
G
L
D
K
V
D
L
I
K
C
E
E
K
G
V
R
V
T
N
T
P
D
V
L
T
D
D
V
A
D
L
A
I
G
L
I
L
A
V
L
R
R
I
C
E
C
D
K
Y
V
R
R
G
A
W
K
-----
F
G
----
D
--
F
K
L
--
T
T
K
F
S
G
K
R
V
G
I
I
G
L
G
R
I
G
L
A
V
A
E
R
A
E
-
A
F
D
C
P
-
I
S
Y
F
-
S
R
S
K
-
K
P
N
T
N
Y
-
T
Y
Y
-
G
S
V
V
---
E
L
A
S
N
S
D
I
L
V
V
A
C
P
L
T
P
E
T
T
H
I
I
N
R
E
V
I
D
A
L
G
P
K
G
V
L
I
N
I
G
R
G
P
H
V
D
E
P
E
L
V
S
A
L
V
E
G
R
L
G
G
A
G
L
D
V
F
E
R
E
P
E
V
--------
P
-
E
--
K
L
F
G
L
-
E
-
N
V
V
L
L
P
H
V
G
S
G
T
V
E
T
R
K
V
M
A
D
L
V
V
G
N
L
E
A
H
F
S
G
-
K
P
L
-----------
56
PsiBlast_CBE
73.01
38%
-109
- C1 -
4NU5
1
PTXD_PSEST
A:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
K
F
R
---
G
W
------
Q
--
P
R
F
Y
-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
-
A
A
K
A
L
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
A
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------
37
PsiBlast_CBE
72.82
38%
-109
- C1 -
4E5M
1
PTXD_PSEST
B:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
Q
F
R
---
G
W
------
Q
--
P
R
F
Y-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
-
A
R
K
A
L
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
R
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------
85
PsiBlast_CBE
72.71
33%
-102
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[80-343]
----------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
---
Q
S
V
E
Q
I
R
E
V
--
A
S
G
--
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
-
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
-
S
D
G
V
E
R
-
A
L
G
L
Q
R
V
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
F
S
--------
F
-
S
QG
P
L
K
D
A
-
P
-
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
D
S
L
K
N
-------
55
PsiBlast_CBE
72.41
38%
-108
- C1 -
4NU5
1
PTXD_PSEST
B:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
K
F
R
---
G
W
------
Q
--
P
R
F
Y
-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
-
A
A
K
A
L
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
A
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------
17
PsiBlast_PDB
72.06
38%
-112
- C1 -
4E5M
1
PTXD_PSEST
A:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
Q
F
R
---
G
W
------
Q
--
P
R
F
Y
-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
-
A
R
K
A
L
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
R
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------
79
PsiBlast_CBE
71.94
33%
-101
- C1 -
1HKU
4
CTBP1_RAT
A:
[83-346]
----------------------------------------------------------------------
L
E
K
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
---
Q
S
V
E
Q
I
R
E
V
--
A
S
G
--
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
-
A
F
G
F
N
-
V
L
F
Y
-
D
P
Y
L
-
S
D
G
I
E
R
-
A
L
G
L
Q
R
V
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
F
S
--------
F
-
S
QG
P
L
K
D
A
-
P
-
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
D
S
L
K
N
-------
53
PsiBlast_CBE
71.16
38%
-112
- C1 -
4NU6
2
PTXD_PSEST
B:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
K
F
R
---
G
W
------
Q
--
P
R
F
Y-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
E
A
K
A
L
-
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
K
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------
54
PsiBlast_CBE
66.54
38%
-107
- C1 -
4NU6
2
PTXD_PSEST
A:
[62-326]
----------------------------------------------------------------------
L
Q
A
C
-
P
E
L
R
V
I
G
C
A
L
K
G
F
D
N
F
D
V
D
A
C
T
A
R
G
V
W
L
T
F
V
P
D
L
L
T
V
P
T
A
E
L
A
I
G
L
A
V
G
L
G
R
H
L
R
A
A
D
A
F
V
R
S
G
K
F
R
---
G
W
------
Q
--
P
R
F
Y
-
G
T
G
L
D
N
A
T
V
G
F
L
G
M
G
A
I
G
L
A
M
A
D
R
L
Q
-
G
W
G
A
T
-
L
Q
Y
H
E
A
K
A
L
-
D
T
Q
T
E
Q
-
R
L
G
-
L
R
Q
V
A
C
S
E
L
F
A
S
S
D
F
I
L
L
A
L
P
L
N
A
D
T
L
H
L
V
N
A
E
L
L
A
L
V
R
P
G
A
L
L
V
N
P
C
R
G
S
V
V
D
E
A
A
V
L
A
A
L
E
R
G
Q
L
G
G
Y
A
A
D
V
F
E
M
E
D
W
A
RADRPQQI
D
-
P
--
A
L
L
A
H
-
P
-
N
T
L
F
T
P
H
I
G
S
A
V
R
A
V
K
L
E
I
E
R
C
A
A
Q
N
I
L
Q
A
L
A
G
E
R
P
I
N
A
V
N
-------