@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4907: (2016-03-02 )
MSSTLFITGATSGFGEACARRFAEAGWSLVLTGRREERLQALAGELSAKTRVLPLTLDVRDRAAMSAAVDNLPEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNIKGLLYSTRLLLPRLIAHGAGASIVNLGSVAGKWPYPGSHVYGGTKAFVEQFSLNLRCDLQGTGVRVTNLEPGLCESEFSLVRFGGDQARYDKTYAGAHPIQPEDIAETIFWIMNQPAHLNINSLEIMPVSQSWAGFAIHRES
Atome Classification :
(27 SA)
.........10........20.....---...30........40.....-...---50--.......----..60........70........80........-90........100.......110.......120.......130........140.--......150.......160.......170-........180...-....------190........200.......210.......220.......230.......240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
S
T
L
F
I
TGATS
G
F
G
E
A
C
A
R
R
F
A
EAG---
W
S
L
V
L
TG
R
R
E
E
R
L
Q
A
L
A
G
EL-SAK---
T
---
R
V
L
P
L
T
L
----DVR
D
R
A
A
M
S
A
A
V
D
N
L
P
E
E
F
A
T
L
R
G
L
I
NNAGLA-LGTDPAQSCDLDD
W
D
T
M
V
DTN
I
K
G
L
L
Y
S
T
R
L
L
L
P
R
L
I
AHGAG-
A
S
I
V
N
LGSVAGK--WPYPGSHVYG
G
T
K
A
F
V
E
QFS
L
N
L
R
C
D
LQ--GT
G
V
R
V
TNLEPGLC-ESE
F
------
S
-
L
V
R
FGGDQ
A
R
YDKTYAGAHPI
Q
P
E
D
I
A
E
T
I
F
W
I
MNQP
A
H
L
N
IN
S
L
E
I
M
PVSQSW
A
G
F
A
I
HRES
47
HHSearch
96.60
100%
-109
- C1 -
2NWQ
1
?
A:
[21-269]
-
S
S
T
L
F
I
T
G
A
T
S
G
F
G
E
A
C
A
R
R
F
A
E
A
G
---
W
S
L
V
L
T
G
R
R
E
E
R
L
Q
A
L
A
G
E
L
-
S
A
K
---
T
---
R
V
L
P
L
T
L
----
D
V
R
D
R
A
A
M
S
A
A
V
D
N
L
P
E
E
F
A
T
L
R
G
L
I
N
N
A
G
L
A
-
L
G
T
D
P
A
Q
S
C
D
L
D
D
W
D
T
M
V
D
T
N
I
K
G
L
L
Y
S
T
R
L
L
L
P
R
L
I
A
H
G
A
G
-
A
S
I
V
N
L
G
S
V
A
G
K
--
W
P
Y
P
G
S
H
V
Y
G
G
T
K
A
F
V
E
Q
F
S
L
N
L
R
C
D
L
Q
--
G
T
G
V
R
V
T
N
L
E
P
G
L
C
-
E
---------------------------
G
A
H
P
I
Q
P
E
D
I
A
E
T
I
F
W
I
M
N
Q
P
A
H
L
N
I
N
S
L
E
I
M
P
V
S
Q
S
W
A
G
F
A
I
H
---
1
PsiBlast_PDB
96.14
98%
-109
- C1 -
2NWQ
1
?
A:
[21-269]
-
S
S
T
L
F
I
T
G
A
T
S
G
F
G
E
A
C
A
R
R
F
A
E
A
G
---
W
S
L
V
L
T
G
R
R
E
E
R
L
Q
A
L
A
G
E
L
-
S
A
K
---
T
---
R
V
L
P
L
T
L
----
D
V
R
D
R
A
A
M
S
A
A
V
D
N
L
P
E
E
F
A
T
L
R
G
L
I
N
N
A
G
L
A
-
L
G
T
D
P
A
Q
S
C
D
L
D
D
W
D
T
M
V
D
T
N
I
K
G
L
L
Y
S
T
R
L
L
L
P
R
L
I
A
H
G
A
G
-
A
S
I
V
N
L
G
S
V
A
G
K
--
W
P
Y
P
G
S
H
V
Y
G
G
T
K
A
F
V
E
Q
F
S
L
N
L
R
C
D
L
Q
--
G
T
G
V
R
V
T
N
L
E
P
G
L
C
-
E
---------------------------
G
A
H
P
I
Q
P
E
D
I
A
E
T
I
F
W
I
M
N
Q
P
A
H
L
N
I
N
S
L
E
I
M
P
V
S
Q
S
W
A
G
F
A
I
H
---
23
PsiBlast_CBE
81.32
52%
-93
- C1 -
3ASV
2
?
D:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
21
PsiBlast_CBE
80.63
52%
-94
- C1 -
3ASV
2
?
F:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
25
PsiBlast_CBE
80.43
52%
-93
- C1 -
3ASV
2
?
B:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
24
PsiBlast_CBE
79.88
52%
-91
- C1 -
3ASV
2
?
C:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
22
PsiBlast_CBE
79.48
52%
-90
- C1 -
3ASV
2
?
E:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
3
PsiBlast_PDB
78.56
52%
-91
- C1 -
3ASV
2
?
A:
[3-248]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
T
E
F
------
S
-
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
26
PsiBlast_CBE
75.51
34%
-92
- C1 -
3RKU
1
YM71_YEAST
D:
[33-279]
-
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
NGD
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
-
D
Q
E
FPN
A
---
K
V
H
V
A
Q
L
----
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
--
D
I
V
N
L
G
S
I
A
G
R
--
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
--
N
T
K
I
R
V
I
L
I
A
P
G
L
V
-
E
T
E
F
------
S
-
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
----------
4
PsiBlast_PDB
73.86
34%
-90
- C1 -
3RKU
1
YM71_YEAST
A:
[33-279]
-
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
NGD
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
-
D
Q
E
F
P
N
A
---
K
V
H
V
A
Q
L
----
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
--
D
I
V
N
L
G
S
I
A
G
R
--
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
--
N
T
K
I
R
V
I
L
I
A
P
G
L
V
-
E
T
E
F
------
S
-
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
----------
48
HHSearch
73.65
49%
-104
- C1 -
3ASU
-
?
A:
[1-240]
--
M
I
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
-----
D
---
N
L
Y
I
A
Q
L
----
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
--
G
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
-
G
G
----------------------------
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
---------
28
PsiBlast_CBE
73.35
34%
-91
- C1 -
3RKU
1
YM71_YEAST
B:
[33-279]
-
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
NGD
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
-
D
Q
E
FPN
A
---
K
V
H
V
A
Q
L
----
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
--
D
I
V
N
L
G
S
I
A
G
R
--
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
--
N
T
K
I
R
V
I
L
I
A
P
G
L
V
-
E
T
E
F
------
S
-
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
----------
2
PsiBlast_PDB
72.94
52%
-99
- C1 -
3ASU
-
?
A:
[3-240]
----
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
---
H
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
K
D
E
L
-
G
D
N
---
L
---
Y
I
A
Q
L
------
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
-
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
N
H
G
--
H
I
I
N
I
G
S
T
A
G
S
--
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
--
G
T
A
V
R
V
T
D
I
E
P
G
L
V
G
G
-----------------------------
V
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
---------
27
PsiBlast_CBE
72.88
34%
-89
- C1 -
3RKU
1
YM71_YEAST
C:
[33-279]
-
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
NGD
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
K
K
T
I
-
D
Q
E
FPN
A
---
K
V
H
V
A
Q
L
----
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
-
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
N
S
G
--
D
I
V
N
L
G
S
I
A
G
R
--
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
--
N
T
K
I
R
V
I
L
I
A
P
G
L
V
-
E
T
E
F
------
S
-
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
----------
29
PsiBlast_CBE
66.34
34%
-111
- C1 -
2EHD
1
?
B:
[4-226]
M
K
G
A
V
L
I
T
G
A
S
R
G
I
G
E
A
T
A
R
L
L
H
A
K
G
---
Y
R
V
G
L
M
A
R
D
E
K
R
L
Q
A
L
A
A
E
L
-
E
G
---------
A
L
P
L
P
G
----
D
V
R
E
E
G
D
W
A
R
A
V
A
A
M
E
E
A
F
G
E
L
S
A
L
V
N
N
A
G
V
G
-
V
-
M
K
P
V
H
E
L
T
L
E
E
W
R
L
V
L
D
T
N
L
T
G
A
F
L
G
I
R
H
A
V
P
A
L
L
R
R
G
-
G
-
G
T
I
V
N
V
G
S
L
A
G
K
--
N
P
F
K
G
G
A
A
Y
N
A
S
K
F
G
L
L
G
L
A
G
A
A
M
L
D
L
R
--
E
A
N
V
R
V
V
N
V
L
P
G
S
V
--------------------------------
K
L
K
P
E
D
V
A
Q
A
V
L
F
A
L
E
M
P
G
H
A
M
V
S
E
I
E
L
R
P
--------------
33
PsiBlast_CBE
64.67
32%
-98
- C1 -
3TFO
5
?
D:
[3-239]
M
D
K
V
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
E
L
G
V
A
G
---
A
K
I
L
L
G
A
R
R
Q
A
R
I
E
A
I
A
T
E
I
R
D
A
G
---
G
---
T
A
L
A
Q
V
L
----
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
V
--
M
P
L
S
P
L
A
A
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
R
S
G
--
Q
I
I
N
I
G
S
I
G
A
L
--
S
V
V
P
T
A
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
--
Q
E
--
S
T
N
I
R
V
T
C
V
N
P
G
V
V
-
E
----------------------------
A
I
A
L
Q
P
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
------------
34
PsiBlast_CBE
64.04
32%
-101
- C1 -
3TFO
5
?
B:
[3-239]
M
D
K
V
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
E
L
G
V
A
G
---
A
K
I
L
L
G
A
R
R
Q
A
R
I
E
A
I
A
T
E
I
R
D
A
G
---
G
---
T
A
L
A
Q
V
L
----
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
V
--
M
P
L
S
P
L
A
A
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
R
S
G
--
Q
I
I
N
I
G
S
I
G
A
L
--
S
V
V
P
T
A
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
--
Q
E
--
S
T
N
I
R
V
T
C
V
N
P
G
V
V
-------------------------------
I
A
L
Q
P
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
------------
6
PsiBlast_PDB
63.92
36%
-88
- C1 -
2JAP
2
?
A:
[11-246]
-----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
---
A
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
G
D
E
L
-
T
A
A
G--
A
---
K
V
H
V
L
E
L
----
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
-
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
K
-
G
T
V
V
Q
M
S
S
I
A
G
R
--
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
-
D
T
E
L
------
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
Q
I
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
-----------
9
PsiBlast_PDB
63.54
26%
-85
- C1 -
1XG5
2
DHR11_HUMAN
A:
[36-276]
-----
L
V
T
G
A
S
G
G
I
G
A
A
V
A
R
A
L
V
Q
Q
G
---
L
K
V
V
G
C
A
R
T
V
G
N
I
E
E
L
A
A
E
C
-
K
S
A
---
G
YP
G
T
L
I
P
Y
R
C
----
D
L
S
N
E
E
D
I
L
S
M
F
S
A
I
R
S
Q
H
S
G
V
D
I
C
I
N
N
A
G
L
A
-
R
-
P
D
T
L
L
S
G
S
T
S
G
W
K
D
M
F
N
V
N
V
L
A
L
S
I
C
T
R
E
A
Y
Q
S
M
K
E
R
N
V
D
D
G
H
I
I
N
I
N
S
M
S
G
H
RV
L
P
L
S
V
T
H
F
Y
S
A
T
K
Y
A
V
T
A
L
T
E
G
L
R
Q
E
L
R
E
A
Q
T
H
I
R
A
T
C
I
S
P
G
V
V
-
E
T
Q
F
------
A
-
F
K
L
H
D
K
D
P
E
K
A
A
A
T
Y
E
---
C
L
K
P
E
D
V
A
E
A
V
I
Y
V
L
S
T
P
A
H
I
Q
I
G
D
I
Q
M
R
P
--------------
31
PsiBlast_CBE
62.84
36%
-87
- C1 -
2JAP
2
?
C:
[11-246]
-----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
---
A
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
G
D
E
L
-
T
A
A
G--
A
---
K
V
H
V
L
E
L
----
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
-
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
K
-
G
T
V
V
Q
M
S
S
I
A
G
R
--
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
-
D
T
E
L
------
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
Q
I
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
-----------
30
PsiBlast_CBE
62.74
36%
-87
- C1 -
2JAP
2
?
D:
[11-246]
-----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
---
A
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
G
D
E
L
-
T
A
A
G--
A
---
K
V
H
V
L
E
L
----
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
-
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
K
-
G
T
V
V
Q
M
S
S
I
A
G
R
--
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
-
D
T
E
L
------
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
Q
I
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
-----------
32
PsiBlast_CBE
62.36
36%
-89
- C1 -
2JAP
2
?
B:
[11-246]
-----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
---
A
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
G
D
E
L
-
T
A
A
G--
A
---
K
V
H
V
L
E
L
----
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
-
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
K
-
G
T
V
V
Q
M
S
S
I
A
G
R
--
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
-
D
T
E
L
------
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
Q
I
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
-----------
7
PsiBlast_PDB
60.78
36%
-90
- C1 -
2JAH
1
?
A:
[11-246]
-----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
---
A
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
G
D
E
L
-
T
A
A
G--
A
---
K
V
H
V
L
E
L
----
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
-
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
--
S
K
-
G
T
V
V
Q
M
S
S
I
A
G
R
--
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
--
E
R
G
V
R
V
V
V
I
E
P
G
T
T
-
D
T
E
L
R-----
G
-
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
Q
I
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
-----------
37
PsiBlast_CBE
60.46
32%
-97
- C1 -
3P19
1
?
B:
[16-251]
-
K
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
---
H
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
N
----------------
L
P
N
T
L
C
A
QV
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
L
G
Q
I
D
T
Q
--
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
N
C
G
--
T
I
I
N
I
S
S
I
A
G
K
--
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
-
K
T
E
L
LS-----------------------
G
G
V
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------
36
PsiBlast_CBE
59.11
32%
-97
- C1 -
3P19
1
?
C:
[16-251]
-
K
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
---
H
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
N
----------------
L
P
N
T
L
CAQV
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
L
G
Q
I
D
T
Q
--
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
N
C
G
--
T
I
I
N
I
S
S
I
A
G
K
--
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
-
K
T
E
L
LS-----------------------
G
G
V
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------
8
PsiBlast_PDB
55.35
32%
-91
- C1 -
3P19
1
?
A:
[15-251]
M
K
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
---
H
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
N
----------------
L
P
N
T
L
C
A
QV
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
L
G
Q
I
D
T
Q
--
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
N
C
G
--
T
I
I
N
I
S
S
I
A
G
K
--
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
-
K
T
E
L
LSHTTS
Q
-
Q
I
K
D
G
Y
D
A
W
R
V
D
M
----
G
G
V
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------
35
PsiBlast_CBE
54.84
32%
-88
- C1 -
3P19
1
?
D:
[16-251]
-
K
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
---
H
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
N
----------------
L
P
N
T
L
CAQV
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
L
G
Q
I
D
T
Q
--
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
N
C
G
--
T
I
I
N
I
S
S
I
A
G
K
--
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
--
A
S
N
V
R
V
M
T
I
A
P
S
A
V
-
K
T
E
L
LSHTTS
Q
-
Q
I
K
D
G
Y
D
A
W
R
V
D
M
----
G
G
V
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------