@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0002: (2017-12-13 )
MIHFSINKNLFLQALNITKRAISSKNAIPILSTVKIDVTNEGVTLIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQNQIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRPILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDDIETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN
Atome Classification :
(20 SA)
.........10........20........30........40........50........--60........70........80........90..-.......100.......110.......120.......130.......140.......150.......160.....-..170-.......180.......190...--...-.200.........210--......-.-220-........-------.230-----.........240-.......250.......260.......270.......280....-...290.......300.......310.......320.......330.......340.......350.......360..-----------------..-----------------...370......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
H
F
SINK
N
L
F
L
Q
A
L
N
I
T
K
R
AISSKNA
I
P
I
L
S
T
V
K
I
D
VTNE
G
V
T
L
IGSN
G
Q
I
S
I
E
N
F
I
S--QKNEDA
G
L
L
I
T
S
L
G
S
I
L
L
E
A
S
F
F
I
N
V
V
S
SLP-
D
V
-
T
L
D
F
K
EIEQN
Q
I
V
L
TSGK
S
E
I
T
L
KGKDSEQYP
R
I
Q
EISAST
P
L
I
L
E
T
K
L
L
K
K
I
I
N
E
T
AFAASTQESR
P
I
L
T
G
V
H
F
-
V
L
S
Q
H
-
K
E
L
K
T
VATDSHRLSQ
K
K
L
T
LEKN--SDD-
F
D
--
V
V
IPS
R
S
L
R
E
F
S
--
A
V
FTDD-I-
E
---
T
V
E
I
F
F
AN-------
N
Q
-------
I
L
F
RSE
N
I
S
F
Y
T
-
R
L
LEGNYPDTDRLIPTDFN
T
T
I
T
F
N
V
V
N
L
R
Q
S
M
E
R
A
R
L
L
S
SATQ-N
G
T
V
K
L
E
IKD
G
V
V
S
A
HVHSPEVGKVNEEIDTDQVTGE
D
L
T
I
SFN
P
T
Y
L
I
D
S
L
K
A
LNSE
K
V
T
I
S
F
ISAVR
P
F
T
LVPADT-----------------
D
E
-----------------
D
F
M
Q
L
ITPVRTN
1
PsiBlast_PDB
95.40
98%
-114
- C3 -
-
2AWA
1
DPO3B_STRPN
A:
[14-389]
-
I
H
F
S
I
N
K
N
L
F
L
Q
A
L
N
T
T
K
R
A
I
S
S
K
N
A
I
P
I
L
S
T
V
K
I
D
V
T
N
E
G
I
T
L
I
G
S
N
G
Q
I
S
I
E
N
F
I
S
--
Q
K
N
E
D
A
G
L
L
I
T
S
L
G
S
I
L
L
E
A
S
F
F
I
N
V
V
S
S
L
P
-
D
V
-
T
L
D
F
K
E
I
E
Q
N
Q
I
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
S
E
Q
Y
P
R
I
Q
E
I
S
A
S
T
P
L
I
L
E
T
K
L
L
K
K
I
I
N
E
T
A
F
A
A
S
T
Q
E
S
R
P
I
L
T
G
V
H
F
-
V
L
S
Q
H
-
K
E
L
K
T
V
A
T
D
S
H
R
L
S
Q
K
K
L
T
L
E
K
N
--
S
D
D
-
F
D
--
V
V
I
P
S
R
S
L
R
E
F
S
--
A
V
F
T
D
D
-
I
-
E
---
T
V
E
I
F
F
A
N
-------
N
Q
-------
I
L
F
R
S
E
N
I
S
F
Y
T
-
R
L
L
E
G
N
Y
P
D
T
D
R
L
I
P
T
D
F
N
T
T
I
T
F
N
V
V
N
L
R
Q
S
M
E
R
A
R
L
L
S
S
A
T
Q
-
N
G
T
V
K
L
E
I
K
D
G
V
V
S
A
H
V
H
S
P
E
V
G
K
V
N
E
E
I
D
T
D
Q
V
T
G
E
D
L
T
I
S
F
N
P
T
Y
L
I
D
S
L
K
A
L
N
S
E
K
V
T
I
S
F
I
S
A
V
R
P
F
T
L
V
P
A
D
T
-----------------
D
E
-----------------
D
F
M
Q
L
I
T
P
V
R
T
-
2
PsiBlast_PDB
88.59
72%
-126
- C3 -
-
2AVT
-
?
A:
[1-377]
M
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
P
--
V
-----
G
L
L
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
-
D
I
-
S
I
N
V
K
E
I
E
Q
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
T
E
N
P
L
I
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
-
V
L
S
N
H
-
K
D
F
K
A
V
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
N
T
--
S
A
D
-
F
M
--
V
V
L
P
S
K
S
L
R
E
F
S
--
A
V
F
T
D
D
-
I
-
E
---
T
V
E
V
F
F
S
P
-------
S
Q
-------
I
L
F
R
S
E
H
I
S
F
Y
T
-
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
S
N
A
T
Q
-
N
G
T
V
K
L
E
I
T
Q
N
H
I
S
A
H
V
N
S
P
E
V
G
K
V
N
E
D
L
D
I
V
S
Q
S
G
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
G
D
E
-----------------
E
E
-----------------
S
F
I
Q
L
I
T
P
V
R
T
-
31
HHSearch
80.44
72%
-55
* C3 *
-
2AVT
-
?
A:
[1-377]
M
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
P
--
V
-----
G
L
L
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
-
D
I
-
S
I
N
V
K
E
I
E
Q
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
T
E
N
P
L
I
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
-
V
L
S
-
N
H
K
D
F
K
A
V
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
N
T
--
S
A
D
-
F
M
--
V
V
L
P
S
K
S
L
R
E
F
S
--
A
V
F
T
D
D
-
I
-
E
---
T
V
E
V
F
F
S
P
-------
S
Q
-------
I
L
F
R
S
E
H
I
S
F
Y
T
-
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
S
N
A
T
Q
N
G
T
-
V
K
L
E
I
T
Q
N
H
I
S
A
H
V
N
S
P
E
V
G
K
V
N
E
D
L
D
I
V
S
Q
S
G
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
G
D
E
-----------------
E
E
-----------------
S
F
I
Q
L
I
T
P
V
R
T
-
5
PsiBlast_PDB
64.38
27%
-54
- C3 -
-
5AH4
-
?
A:
[15-398]
-
L
K
F
R
V
V
R
E
D
F
A
D
A
V
A
W
V
A
R
S
L
P
T
R
----
V
L
A
G
V
L
L
T
G
T
D
E
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
V
K
V
S
--
A
E
-------
I
A
S
A
G
S
V
L
V
S
G
R
L
L
S
D
I
T
K
A
L
P
-
A
K
-
P
V
E
V
S
-
V
E
G
T
R
V
S
L
T
C
G
S
A
R
F
S
L
P
T
L
A
V
E
D
Y
P
A
L
P
A
L
P
E
E
T
G
V
I
-
A
S
D
L
F
A
E
A
I
G
Q
V
A
V
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
-
E
I
S
-
G
-
E
S
V
V
L
A
A
T
D
R
F
R
L
A
V
R
E
L
T
W
V
T
T
--
A
G
D
-
V
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
--
K
A
G
----
N
-
Q
----
V
H
L
A
L
G
S
-------
G
A
SVGKDG
L
L
G
I
R
S
E
G
K
R
S
T
T
-
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
A
E
H
T
A
V
A
T
I
G
V
A
E
L
T
E
A
I
K
R
V
A
L
V
--
A
D
R
-
G
A
Q
I
R
M
E
F
S
D
D
T
L
K
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
P
V
D
-
F
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
G
S
L
H
S
E
R
V
T
F
G
F
T
T
P
S
R
P
A
V
L
R
P
A
G
E
-----------------
D
D
GAGGSGPF
P
A
A
K
T
----
D
Y
V
Y
L
L
M
P
V
R
--
4
PsiBlast_PDB
63.94
27%
-59
- C3 -
-
5AH2
-
?
A:
[15-398]
-
L
K
F
R
V
V
R
E
D
F
A
D
A
V
A
W
V
A
R
S
L
P
T
R
P
T
I
P
V
L
A
G
V
L
L
T
G
T
D
E
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
V
K
V
S
--
A
E
-------
I
A
S
A
G
S
V
L
V
S
G
R
L
L
S
D
I
T
K
A
L
P
-
A
K
-
P
V
E
V
S
-
V
E
G
T
R
V
S
L
T
C
G
S
A
R
F
S
L
P
T
L
A
V
E
D
Y
P
A
L
P
A
L
P
E
E
T
G
V
I
-
A
S
D
L
F
A
E
A
I
G
Q
V
A
V
A
A
G
R
---
L
P
M
L
T
G
I
R
V
-
E
I
S
-
G
-
E
S
V
V
L
A
A
T
D
R
F
R
L
A
V
R
E
L
T
W
V
T
T
--
A
G
D
-
V
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
--
K
A
G
T
D
G
-
N
-
Q
----
V
H
L
A
L
G
S
-------
G
A
SVGKDG
L
L
G
I
R
S
E
G
K
R
S
T
T
-
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
A
E
H
T
A
V
A
T
I
G
V
A
E
L
T
E
A
I
K
R
V
A
L
V
--
A
D
R
-
G
A
Q
I
R
M
E
F
S
D
D
T
L
K
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
P
V
D
-
F
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
G
S
L
H
S
E
R
V
T
F
G
F
T
T
P
S
R
P
A
V
L
R
P
A
G
E
-------------------GGSGPF
P
A
A
K
T
------
D
Y
V
Y
L
L
M
P
V
R
--
45
HHSearch
63.93
26%
-50
- C3 -
-
5AGV
3
DPO3B_MYCTU
A:
[16-405]
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
H
V
E
G
N
-
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
-
E
I
L
-
G
-
E
T
V
V
L
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
SP
D
I
E
-
A
A
--
V
L
V
P
A
K
T
L
A
E
A
A
--
K
A
G
I
G
G
---
S
---
D
V
R
L
S
L
G
T
GPGVGKD
G
L
-------
L
G
I
S
G
N
G
K
R
S
T
T
-
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
A
D
R
-
G
-
A
Q
-
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
-
D
Y
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
DDRPLNGNGPFPAV---
S
T
-----------------
D
Y
V
Y
L
L
M
P
V
R
L
P
46
HHSearch
63.61
26%
-51
- C3 -
-
3RB9
-
DPO3B_MYCTU
A:
[12-401]
D
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
H
V
E
G
N
-
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
-
E
E
T
G
L
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
-
E
I
L
-
G
-
E
T
V
V
L
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
SP
D
I
E
-
A
A
--
V
L
V
P
A
K
T
L
A
E
A
A
--
K
A
G
I
G
G
---
S
---
D
V
R
L
S
L
G
T
GPGVGKD
G
L
-------
L
G
I
S
G
N
G
K
R
S
T
T
-
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
A
D
R
-
G
-
A
Q
-
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
-
D
Y
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
DDRPVAGLNGN
G
P
F
P
AV
S
T
-----------------
D
Y
V
Y
L
L
M
P
V
R
L
P
33
HHSearch
62.81
27%
-63
- C3 -
-
3T0P
8
?
B:
[1-367]
G
M
K
L
I
C
S
K
A
N
L
L
K
G
V
N
I
V
S
K
A
V
P
T
R
T
T
M
A
I
L
E
C
I
L
I
D
A
S
A
N
E
I
K
L
M
A
N
D
M
E
L
G
I
E
T
I
I
D
--
G
T
-------
I
E
E
R
G
I
I
A
L
D
A
K
I
F
S
E
I
V
R
K
L
P
-
D
N
-
D
V
T
I
E
T
D
A
S
F
K
T
V
I
S
C
E
K
A
K
F
N
I
I
G
K
S
G
D
D
F
S
Y
I
P
Y
V
E
R
N
E
S
I
V
L
S
Q
F
T
L
K
E
V
I
R
Q
T
I
F
S
I
A
D
N
D
N
N
K
L
M
T
G
E
L
F
-
E
I
E
-
E
-
N
K
L
R
V
V
S
L
D
G
H
R
I
S
I
R
Y
I
E
M
K
N
H
--
Y
D
S
-
K
K
--
V
V
V
P
G
K
T
L
Q
E
I
S
--
K
I
I
P
G
S
A
D
-
E
---
D
V
V
I
Y
I
T
N
-------
N
H
-------
I
V
F
E
F
E
N
T
T
V
V
S
-
R
L
I
E
G
E
Y
F
K
I
D
Q
M
L
S
S
D
Y
D
T
K
V
R
I
N
K
R
E
L
L
D
C
I
D
R
A
T
L
L
V
K
E
G
D
K
K
P
-
I
I
M
N
I
T
D
G
N
M
E
L
R
I
N
S
-
F
I
G
S
M
N
E
D
I
D
I
-
D
K
D
G
K
D
I
M
I
G
F
N
P
K
F
F
I
D
A
L
R
V
I
D
E
E
E
V
N
L
Y
M
V
N
P
K
A
P
C
F
I
K
D
D
-------------------
E
G
-----------------
K
F
I
Y
L
I
L
P
V
N
F
N
11
PsiBlast_PDB
62.49
27%
-56
- C3 -
-
3T0P
12
?
A:
[11-366]
----------
L
L
K
G
V
N
I
V
S
K
A
V
P
T
R
T
T
M
A
I
L
E
C
I
L
I
D
A
S
A
N
E
I
K
L
M
A
N
D
M
E
L
G
I
E
T
I
I
D
--
G
T
I
E
E
R
G
I
-------
I
A
L
D
A
K
I
F
S
E
I
V
R
K
L
P
-
D
N
-
D
V
T
I
E
T
D
A
S
F
K
T
V
I
S
C
E
K
A
K
F
N
I
I
G
K
S
G
D
D
F
S
Y
I
P
Y
V
E
R
N
E
S
I
V
L
S
Q
F
T
L
K
E
V
I
R
Q
T
I
F
S
I
A
D
N
D
N
N
K
L
M
T
G
E
L
F
-
E
I
E
E
N
-
K
-
L
R
V
V
S
L
D
G
H
R
I
S
I
R
Y
I
E
M
K
N
H
--
Y
D
S
-
K
K
--
V
V
V
P
G
K
T
L
Q
E
I
S
--
K
I
I
P
G
S
-
A
D
E
---
D
V
V
I
Y
I
T
N
-------
N
H
-------
I
V
F
E
F
E
N
T
T
V
V
S
-
R
L
I
E
G
E
Y
F
K
I
D
Q
M
L
S
S
D
Y
D
T
K
V
R
I
N
K
R
E
L
L
D
C
I
D
R
A
T
L
L
V
K
E
-
D
-
K
K
P
I
I
M
N
I
T
D
G
N
M
E
L
R
I
N
S
F
-
I
G
S
M
N
E
D
I
-
D
I
D
K
D
G
K
D
I
M
I
G
F
N
P
K
F
F
I
D
A
L
R
V
I
D
E
E
E
V
N
L
Y
M
V
N
P
K
A
P
C
F
I
--
K
D
D
-----------------
E
G
-----------------
K
F
I
Y
L
I
L
P
V
N
F
-
7
PsiBlast_PDB
59.70
27%
-36
- C3 -
-
5AGV
3
DPO3B_MYCTU
A:
[17-403]
-
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
-
H
V
E
G
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
E
T
-
V
V
L
--
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
--
S
P
D
-
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
G
S
D
-
V
-
R
L
S
L
G
T
G
P
G
V
G
K
-------
D
G
-------
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
R
-
G
A
Q
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
D
Y
-
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
-----------------
D
D
RPLNGNGPFPAVST---
D
Y
V
Y
L
L
M
P
V
R
--
6
PsiBlast_PDB
59.66
27%
-51
- C3 -
-
5AGU
2
DPO3B_MYCTU
A:
[17-403]
-
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
------
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
-
H
V
E
G
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
E
T
-
V
V
L
--
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
--
S
P
D
-
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
G
S
D
-
V
-
R
L
S
L
G
T
G
P
G
V
G
K
-------
D
G
-------
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
----
A
Q
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
D
Y
-
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
-------------------NGNGP
F
P
A
V
S
T
------
D
Y
V
Y
L
L
M
P
V
R
--
10
PsiBlast_PDB
59.27
27%
-35
- C3 -
-
3RB9
-
DPO3B_MYCTU
A:
[13-399]
-
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
-
H
V
E
G
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
E
T
-
V
V
L
--
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
--
S
P
D
-
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
KA
G
I
G
G
S
D
-
V
-
R
L
S
L
G
T
G
P
G
V
G
K
-------
D
G
-------
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
R
-
G
A
Q
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
D
Y
-
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
-----------------
D
D
RPVAGLNGN
G
P
F
P
AVST
D
Y
V
Y
L
L
M
P
V
R
--
8
PsiBlast_PDB
59.21
27%
-47
- C3 -
-
3P16
-
DPO3B_MYCTU
A:
[13-399]
-
L
T
F
R
L
L
R
E
S
F
A
D
A
V
S
W
V
A
K
N
L
P
A
R
P
A
V
P
V
L
S
G
V
L
L
T
G
S
D
N
G
L
T
I
S
G
F
D
Y
E
V
S
A
E
A
Q
V
G
--
A
E
-------
I
V
S
P
G
S
V
L
V
S
G
R
L
L
S
D
I
T
R
A
L
P
-
N
K
-
P
V
D
V
-
H
V
E
G
N
R
V
A
L
T
C
G
N
A
R
F
S
L
P
T
M
P
V
E
D
Y
P
T
L
P
T
L
P
E
E
T
G
L
-
L
P
A
E
L
F
A
E
A
I
S
Q
V
A
I
A
A
G
R
D
D
T
L
P
M
L
T
G
I
R
V
E
I
L
G
E
T
-
V
V
L
--
A
A
T
D
R
F
R
L
A
V
R
E
L
K
W
S
A
S
--
S
P
D
-
I
E
A
A
V
L
V
P
A
K
T
L
A
E
A
A
K
A
G
I
G
G
S
D
-
V
-
R
L
S
L
G
T
G
P
G
V
G
K
-------
D
G
-------
L
L
G
I
S
G
N
G
K
R
S
T
T
R
L
L
D
A
E
F
P
K
F
R
Q
L
L
P
T
E
H
T
A
V
A
T
M
D
V
A
E
L
I
E
A
I
K
L
V
A
L
V
--
A
D
R
-
G
A
Q
V
R
M
E
F
A
D
G
S
V
R
L
S
A
G
A
D
D
V
G
R
A
E
E
D
L
V
V
D
Y
-
A
G
E
P
L
T
I
A
F
N
P
T
Y
L
T
D
G
L
S
S
L
R
S
E
R
V
S
F
G
F
T
T
A
G
K
P
A
L
L
R
P
V
S
G
-----------------
D
-AVST-------------
D
Y
V
Y
L
L
M
P
V
R
--
12
PsiBlast_PDB
56.85
25%
-11
- C3 -
-
4TR8
-
?
A:
[17-382]
-
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
--
L
--
E
D
A
----
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
-
L
I
D
I
R
-
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
-
E
V
N
-
G
-
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
--
S
Q
D
R
H
Q
--
V
I
V
P
R
K
G
I
L
E
L
A
--
R
L
L
T
E
Q
-
D
-
G
---
E
V
G
I
V
L
G
Q
-------
H
H
-------
I
R
A
T
T
G
E
F
T
F
T
S
-
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
-
R
G
-
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
-
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
-
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
-----------------
N
D
-----------------
D
S
A
Y
V
V
M
P
M
R
--
20
PsiBlast_PDB
54.01
22%
-1
- C3 -
-
3D1F
2
DPO3B_ECOLI
A:
[1-344]
-
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
--------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
-
E
G
-
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
-
E
-
T
E
G
-
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
--
L
P
S
-
H
S
--
V
I
V
P
R
K
G
V
I
E
L
M
--
R
M
L
D
G
G
-
D
-
N
---
P
L
R
V
Q
I
G
S
-------
N
N
-------
I
R
A
H
V
G
D
F
I
F
T
S
-
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
-
R
G
-
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
-
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
----------------------------------------------------------
41
HHSearch
53.45
22%
-19
- C3 -
-
4K3L
8
DPO3B_ECOLI
B:
[1-366]
-
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
--
L
V
------
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
-
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
-
E
T
E
-
G
-
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
--
L
P
S
-
H
S
--
V
I
V
P
R
K
G
V
I
E
L
M
--
R
M
L
D
G
G
-
D
-
N
---
P
L
R
V
Q
I
G
S
-------
N
N
-------
I
R
A
H
V
G
D
F
I
F
T
S
-
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
-
R
G
-
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
-
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
-
A
-----------------
S
Q
-----------------
S
A
A
Y
V
V
M
P
M
R
L
-
32
HHSearch
53.00
22%
-48
- C- -
-
1VPK
-
?
A:
[1-366]
-
M
K
V
T
V
T
T
L
E
L
K
D
K
I
T
I
A
S
K
A
L
A
K
K
S
V
K
P
I
L
A
G
F
L
F
E
V
K
D
G
N
F
Y
I
C
A
T
D
L
E
T
G
V
K
A
T
V
N
--
A
A
------
E
I
S
G
E
A
R
F
V
V
P
G
D
V
I
Q
K
M
V
K
V
L
P
-
D
E
-
I
T
E
L
S
L
E
G
D
-
A
L
V
I
S
S
G
S
T
V
F
R
I
T
T
M
P
A
D
E
F
P
E
I
T
P
A
E
S
G
I
T
F
E
V
D
T
S
L
L
E
E
M
V
E
K
V
I
F
A
A
A
K
D
E
F
M
R
N
L
N
G
V
F
W
-
E
L
H
-
K
-
N
L
L
R
L
V
A
S
D
G
F
R
L
A
L
A
E
E
Q
I
E
N
---
E
E
E
-
A
S
--
F
L
L
S
L
K
S
M
K
E
V
Q
--
N
V
L
D
N
T
T
E
-
P
---
T
I
T
V
R
Y
D
G
-------
R
R
-------
V
S
L
S
T
N
D
V
E
T
V
M
-
R
V
V
D
A
E
F
P
D
Y
K
R
V
I
P
E
T
F
K
T
K
V
V
V
S
R
K
E
L
R
E
S
L
K
R
V
M
V
I
A
S
K
G
S
-
E
S
-
V
K
F
E
I
E
E
N
V
M
R
L
V
S
K
S
P
D
Y
G
E
V
V
D
E
V
E
V
-
Q
K
E
G
E
D
L
V
I
A
F
N
P
K
F
I
E
D
V
L
K
H
I
E
T
E
E
I
E
M
N
F
V
D
S
T
S
P
C
Q
I
N
P
L
-
D
-----------------
I
S
-----------------
G
Y
L
Y
I
V
M
P
I
R
L
A
44
HHSearch
52.95
24%
-19
- C3 -
-
4TR8
-
?
B:
[16-383]
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
--
L
E
------
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
-
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
----
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
-
E
V
N
-
G
-
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S-
Q
D
R
-
H
Q
--
V
I
V
P
R
K
G
I
L
E
L
A
--
R
L
L
T
E
Q
-
D
-
G
---
E
V
G
I
V
L
G
Q
-------
H
H
-------
I
R
A
T
T
G
E
F
T
F
T
S
-
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
-
R
G
-
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
-
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
-
D
-----------------
N
D
-----------------
D
S
A
Y
V
V
M
P
M
R
L
-
42
HHSearch
52.43
22%
-14
- C3 -
-
3BEP
2
DPO3B_ECOLI
A:
[1-366]
-
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
--
L
V
------
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
-
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
-
E
T
E
-
G
-
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
--
L
P
S
-
H
S
--
V
I
V
P
R
K
G
V
I
E
L
M
--
R
M
L
D
G
G
-
D
-
N
---
P
L
R
V
Q
I
G
S
-------
N
N
-------
I
R
A
H
V
G
D
F
I
F
T
S
-
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
-
R
G
-
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
-
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
-
A
-----------------
S
Q
-----------------
S
A
A
Y
V
V
M
P
M
R
L
-
16
PsiBlast_PDB
52.38
22%
-2
- C3 -
-
1UNN
-
DPO3B_ECOLI
A:
[1-344]
-
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
--------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
-
E
G
-
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
-
E
-
T
E
G
-
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
--
L
P
S
-
H
S
--
V
I
V
P
R
K
G
V
I
E
L
M
--
R
M
L
D
G
G
-
D
-
N
---
P
L
R
V
Q
I
G
S
-------
N
N
-------
I
R
A
H
V
G
D
F
I
F
T
S
-
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
-
R
G
-
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
-
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
----------------------------------------------------------