@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKA7: (2017-10-25 )
MSDSSNQLMPLSLSAPGVNLGAYISTVNQIPILTAEQEKELAERYYYDQDLDAAKMLVMSHLRFVVHIARSYAGYGLPQGDLIQEGNLGLMKAVKRFDPNMGVRLVSFAVHWIKAEIHEYVIRNWRIVKIATTKAQRKLFFNLRSLKKSSKKLTLEEAQSIANDLNVTPEQVLEMEGRLTAYDAAFEAQGDDDDDTPHTAPVLYLEDNRYDPARLVENEDWEEQSTSALHDAMNQLDDRSRNILQRRWLDDDKSTLHELAAEYNVSAERIRQLEKNAMEKIKVAMSAS
Atome Classification :
(20 SA)
.........10........20........30........40...-----------------------------.-----------------------------....50---------------------------------------------------------------------.....-....60........70........80........90........100.......110.......120.......130---------.......140.......150--....-...160....--...170---.......180.......190.......200......-.----210.......220.......230.......240......--.250-........260.......270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSDSSN
Q
L
M
P
L
SLSAPGVN
L
G
A
Y
I
STVNQIPIL
T
A
E
Q
E
K
E
L
A
E
R
-----------------------------Y-----------------------------YYDQD----------------------------------------------------------------------L
D
A
A
K
-
M
L
V
M
S
H
L
R
F
V
V
H
I
A
R
S
Y
AGYGLPQ
G
D
LIQEGN
L
G
L
M
K
A
V
K
R
FDPNMG
V
R
L
V
S
F
A
V
H
W
I
K
A
E
I
H
E
Y
V
I
RN
W
R
I
V
K
I
AT---------
T
K
A
Q
R
K
L
F
F
N
L
R
S
L
K
KSSKK--L
T
L
E
-
E
A
Q
S
I
A
NDLN--V
T
P
E
Q
V
---
L
E
MEGR
L
T
A
Y
D
A
A
FEAQGDDDDDTPHT
A
P
V
L
Y
L
EDN-R----Y
D
P
A
R
LVENEDW
E
E
Q
S
T
S
A
L
H
D
A
M
N
Q
L
D
D
R
S
R
N
I
L
Q
R
RW--LDD--
D
K
S
T
L
H
E
L
A
A
EYNV
S
A
E
R
I
R
Q
L
E
K
N
A
M
E
K
I
K
V
A
MSAS
15
PsiBlast_PDB
76.09
26%
37
- C3 -
-
5TW1
-
?
F:
[163-453]
----------------
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
-----------------------------
I
EAGLYATQKLAELAEKGEKLPVQQRRDMQ
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
HMVEVINKL
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
--
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVVA
V
D
A
V
S
F
T
L
L
Q
D
-------
Q
L
Q
S
V
L
E
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
5
PsiBlast_PDB
74.94
26%
11
- C3 -
-
5UH6
3
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
3
PsiBlast_PDB
74.63
28%
-51
- C3 -
-
5IPN
-
RPOS_ECOLI
F:
[61-314]
----------------------
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
-----------------------------
A
-----------------------------
L
R
G
-
D
----------------------------------------------------------------------
V
A
S
R
R
-
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
---------
H
I
V
-
K
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
K
--
L
D
H
E
P
S
A
E
E
I
A
E
Q
L
D
--
K
P
V
D
D
V
SRM
L
R
L
N
E
R
I
T
S
V
D
T
P
L
G
G
------
D
S
E
K
A
L
L
D
I
L
A
D
E
K
-
E
----
N
G
P
E
D
T
T
Q
D
D
D
M
K
Q
S
I
V
K
W
L
F
----
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
GL
L
G
Y
--
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
------
6
PsiBlast_PDB
74.21
26%
12
- C3 -
-
5UH8
3
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
4
PsiBlast_PDB
74.21
26%
15
- C3 -
-
5UH5
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
2
PsiBlast_PDB
74.18
28%
-52
- C3 -
-
5IPM
-
RPOS_ECOLI
F:
[61-314]
----------------------
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
-----------------------------
A
-----------------------------
L
R
G
-
D
----------------------------------------------------------------------
V
A
S
R
R
-
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
---------
H
I
V
-
K
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
K
--
L
D
H
E
P
S
A
E
E
I
A
E
Q
L
D
--
K
P
V
D
D
V
SRM
L
R
L
N
E
R
I
T
S
V
D
T
P
L
G
G
------
D
S
E
K
A
L
L
D
I
L
A
D
E
K
-
E
----
N
G
P
E
D
T
T
Q
D
D
D
M
K
Q
S
I
V
K
W
L
F
----
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
GL
L
G
Y
--
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
------
10
PsiBlast_PDB
74.14
26%
15
- C3 -
-
5UHC
3
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
1
PsiBlast_PDB
74.07
28%
-48
- C3 -
-
5IPL
-
RPOS_ECOLI
F:
[61-314]
----------------------
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
-----------------------------
A
-----------------------------
L
R
G
-
D
----------------------------------------------------------------------
V
A
S
R
R
-
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
---------
H
I
V
-
K
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
K
--
L
D
H
E
P
S
A
E
E
I
A
E
Q
L
D
--
K
P
V
D
D
V
SRM
L
R
L
N
E
R
I
T
S
V
D
T
P
L
G
G
------
D
S
E
K
A
L
L
D
I
L
A
D
E
K
-
E
----
N
G
P
E
D
T
T
Q
D
D
D
M
K
Q
S
I
V
K
W
L
F
----
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
GL
L
G
Y
--
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
------
7
PsiBlast_PDB
74.05
26%
13
- C3 -
-
5UH9
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
12
PsiBlast_PDB
73.68
26%
10
- C3 -
-
5UHE
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
47
HHSearch
73.63
27%
19
- C3 -
-
1L9U
-
SIGA_THEAQ
H:
[2-322]
----------------
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
I
D
L
A
R
K
-----------------------------
V
------------------------------
E
E
G
M
EAIKKLSEATGLDQELIREVVRAKILGTARVEEVDGKLKSLPKELKRYLHIAREG---------------
E
A
A
R
Q
-
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
---------
H
M
V
E
--
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
EL
G
R
E
P
-
S
Y
E
E
I
A
E
A
M
G
PG
W
D
A
K
R
V
---
E
E
T
L
K
I
A
-
Q
E
P
V
S
L
E
T
P
I
------------
D
F
I
P
D
E
-
N
L---
P
S
P
V
E
A
A
A
Q
S
----
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
--
G
L
I
DG
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
--
43
HHSearch
73.60
25%
-38
- C3 -
-
5IPM
-
RPOS_ECOLI
F:
[53-319]
--------------
R
V
L
D
A
T
Q
L
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
-----------------------------
A
------------------------------
L
R
G
D
----------------------------------------------------------------------
V
A
S
R
R
-
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
---------
H
I
V
K
--
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
KL
D
H
E
P
-
S
A
E
E
I
A
E
Q
L
D
--
K
P
V
D
D
V
---
S
R
M
L
R
L
N
-
E
R
I
T
S
V
D
T
P
L
G
G
D
S
E
K
---
A
L
L
D
I
L
A
D
E
K
E
----
N
G
P
E
D
T
T
Q
D
D
D
M
----
K
Q
S
I
V
K
W
L
F
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
--
G
L
L
GY
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
E
I
L
Q
T
-
14
PsiBlast_PDB
73.30
26%
9
- C3 -
-
5UHG
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
-
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
44
HHSearch
73.17
25%
-37
- C3 -
-
5IPL
-
RPOS_ECOLI
F:
[53-319]
--------------
R
V
L
D
A
T
Q
L
Y
L
G
E
I
G
Y
S
P
L
L
T
A
E
E
E
V
Y
F
A
R
R
-----------------------------
A
------------------------------
L
R
G
D
----------------------------------------------------------------------
V
A
S
R
R
-
R
M
I
E
S
N
L
R
L
V
V
K
I
A
R
R
Y
G
N
R
G
L
A
L
L
D
L
I
E
E
G
N
L
G
L
I
R
A
V
E
K
F
D
P
E
R
G
F
R
F
S
T
Y
A
T
W
W
I
R
Q
T
I
E
R
A
I
M
N
Q
T
R
T
I
R
L
P
I
---------
H
I
V
K
--
E
L
N
V
Y
L
R
T
A
R
E
L
S
H
KL
D
H
E
P
-
S
A
E
E
I
A
E
Q
L
D
--
K
P
V
D
D
V
---
S
R
M
L
R
L
N
-
E
R
I
T
S
V
D
T
P
L
G
G
D
S
E
K
---
A
L
L
D
I
L
A
D
E
K
E
----
N
G
P
E
D
T
T
Q
D
D
D
M
----
K
Q
S
I
V
K
W
L
F
E
L
N
A
K
Q
R
E
V
L
A
R
R
F
--
G
L
L
GY
E
A
A
T
L
E
D
V
G
R
E
I
G
L
T
R
E
R
V
R
Q
I
Q
V
E
G
L
R
R
L
R
E
I
L
Q
T
-
13
PsiBlast_PDB
72.56
26%
17
- C3 -
-
5UHF
1
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
8
PsiBlast_PDB
72.46
26%
13
- C3 -
-
5UHA
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
G
D
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
46
HHSearch
71.58
27%
-49
- C3 -
-
4XLN
1
SIGA_THEAQ
L:
[103-337]
----------------------------------------------------------------------------------------------------------
E
G
----------------------------------------------------------------------
E
A
A
R
Q
-
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
---------
H
M
V
E
--
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
EL
G
R
E
P
-
S
Y
E
E
I
A
E
A
M
G
PG
W
D
A
K
R
V
---
E
E
T
L
K
I
A
-
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
---
S
F
Y
G
D
F
I
P
D
E
-
N
L---
P
S
P
V
E
A
A
A
Q
S
L
----
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
--
G
L
I
DG
R
E
H
T
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
--
9
PsiBlast_PDB
70.63
26%
25
- C3 -
-
5UHB
1
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
11
PsiBlast_PDB
69.78
26%
32
- C3 -
-
5UHD
2
SIGA_MYCTU
F:
[221-515]
------------
L
T
A
S
A
D
S
V
R
A
Y
L
K
Q
I
G
K
V
A
L
L
N
A
E
E
E
V
E
L
A
K
R
I
E
A
G
L
Y
A
T
Q
L
M
T
E
L
S
E
R
G
E
K
L
P
A
A
Q
R
R
D
M
M
-----------------------------
W
I
C
R
D
----------------------------------------------------------------------
G
D
R
A
K
N
H
L
L
E
A
N
L
R
L
V
V
S
L
A
K
R
Y
T
G
R
G
M
A
F
L
D
L
I
Q
E
G
N
L
G
L
I
R
A
V
E
K
F
D
Y
T
K
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
A
M
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
V
I
N
K
L
G
R
I
Q
R
E
L
L
Q
D
L
------
G
R
E
--
P
T
P
E
-
E
---
L
A
K
E
M
D
--
I
T
P
E
K
V
---
L
E
I
Q
Q
Y
A
R
E
P
I
S
L
D
Q
T
I
--
E
G
D
S
Q
L
G
D
----
F
I
E
D
S
-
E
AVV
A
V
D
A
V
S
F
T
L
L
Q
D
Q
-------
L
Q
S
V
L
D
T
L
S
E
R
E
A
G
V
V
R
L
R
F
GL
T
D
G
--
Q
P
R
T
L
D
E
I
G
Q
V
Y
G
V
T
R
E
R
I
R
Q
I
E
S
K
T
M
S
K
L
R
------
45
HHSearch
68.34
27%
28
- C3 -
-
2A6H
-
?
F:
[74-413]
------------
K
I
S
T
S
D
P
V
R
Q
Y
L
H
E
I
G
Q
V
P
L
L
T
L
E
E
E
V
E
L
A
R
K
-----------------------------
V
------------------------------
E
E
G
M
EAIKKLSEITGLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIAREG
E
A
A
R
Q
-
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
---------
H
M
V
E
--
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
EL
G
R
E
P
-
T
Y
E
E
I
A
E
A
M
G
PG
W
D
A
K
R
V
---
E
E
T
L
K
I
A
-
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
---
S
F
Y
G
D
F
I
P
D
E
-
H
L---
P
S
P
V
D
A
A
T
Q
S
L
----
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
--
G
L
I
DG-----
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
--