@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUU4: (2017-12-20 )
MTKRTPISFEFFPPKTDASAEKLRIVHQELQHLNPEFFSITYGAGGSTRERTLAAIEDFNGKGTPVAPHLSCIGDDKTRIAELLDLYKAQGIDRIVALRGDLPSGQVGLGELPYAQDLVRFIREHSGDHFHIEVAAYPEMHPQAESLDSDIQRFIEKVQAGANAGITQFFFNPDSYFYFIERLEKAGINIPVAPGIMPITNASNLIRFADGTGAEIPRWIRKQLQAYGDDSESIKAFGHEVVVKLCERLIAGGAPSLHFYSMNQVEPTRQLVVDLGLN
Atome Classification :
(40 SA)
.......-..10........20........30......--..40........50........60-.-.......70........80........90........100.....----..110.----......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270......--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTKRT
P
I
-
S
F
E
FFPPKTDA
S
A
E
K
L
R
I
V
H
Q
E
L
Q
HLNP
E
F
--
F
S
I
T
YGAGGSTR
E
R
T
L
A
A
I
EDFNG-K-GTPVAP
H
L
S
CIGD
D
K
T
R
I
A
E
L
L
D
L
Y
K
AQGI
D
R
I
V
A
LRGDLPSGQV----GLGELP----
Y
A
Q
D
L
V
R
F
I
R
EHSG
D
H
F
H
I
E
V
A
AYPEMHP
Q
A
E
S
L
D
S
D
I
Q
R
F
I
E
K
V
QAGANAG
I
T
Q
F
F
FNP
D
S
Y
F
Y
F
I
E
R
L
E
KAGINIPVAPGIMPITNA
S
N
L
I
R
FADGTG
A
E
I
P
R
W
I
R
K
Q
L
Q
AYGDD
S
E
S
I
K
A
F
G
H
E
V
V
V
K
L
C
E
R
L
IAGGAP
S
L
H
F
Y
SMNQVE
P
T
R
Q
L
V
V
DLGLN--
50
HHSearch
84.93
41%
-69
- C11 -
-
1V93
7
?
A:
[11-289]
--
R
G
P
L
F
-
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
F
R
P
H
P
E
G
F
R
----
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
---
51
HHSearch
84.58
41%
-62
- C11 -
-
3APT
1
?
A:
[11-289]
--
R
G
P
L
F
-
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
F
R
P
H
P
E
G
F
R
----
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
---
70
Fugue
82.29
38%
-23
- C11 -
-
1B5T
1
METF_ECOLI
A:
[1-275]
--
G
Q
I
N
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
G
----
K
--
P
E
M
----
Y
A
S
D
L
V
T
L
L
K
E
V
--
A
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
PA
4
PsiBlast_PDB
82.18
39%
-27
- C11 -
-
1B5T
1
METF_ECOLI
A:
[5-272]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
-----
G
K
P
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
36
PsiBlast_CBE
82.09
39%
-29
- C11 -
-
1ZP3
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
-------
K
P
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
3
PsiBlast_PDB
81.94
41%
16
- C11 -
-
1V93
7
?
A:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
21
PsiBlast_CBE
81.83
41%
12
- C11 -
-
3APY
1
?
H:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
1
PsiBlast_PDB
81.76
41%
14
- C11 -
-
3APT
1
?
A:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
44
PsiBlast_CBE
81.74
39%
-32
- C11 -
-
3FST
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
-------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
34
PsiBlast_CBE
81.59
39%
-32
- C11 -
-
1ZPT
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
27
PsiBlast_CBE
81.53
41%
15
- C11 -
-
3APY
1
?
B:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
2
PsiBlast_PDB
81.49
41%
14
- C11 -
-
3APY
1
?
A:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
12
PsiBlast_PDB
81.41
38%
-30
- C11 -
-
3FSU
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
42
PsiBlast_CBE
81.37
39%
-30
- C11 -
-
2FMN
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
35
PsiBlast_CBE
81.31
39%
-32
- C11 -
-
1ZP3
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
26
PsiBlast_CBE
81.29
41%
16
- C11 -
-
3APY
1
?
C:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
24
PsiBlast_CBE
81.21
41%
16
- C11 -
-
3APY
1
?
E:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
23
PsiBlast_CBE
81.17
41%
18
- C11 -
-
3APY
1
?
F:
[9-290]
-
A
R
R
G
P
L
F
S
F
E
F
F
P
P
K
D
P
E
G
E
E
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
F
--
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
-
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
----
V
F
R
P
H
P
EGFR
Y
A
A
E
L
V
A
L
I
R
E
R
Y
G
D
R
V
S
V
G
G
A
A
Y
P
E
G
H
P
E
S
E
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
E
V
C
G
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
R
Q
V
A
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
--
5
PsiBlast_PDB
81.13
39%
-33
- C11 -
-
1ZP3
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
------------
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
32
PsiBlast_CBE
81.06
39%
-32
- C11 -
-
1ZRQ
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
9
PsiBlast_PDB
81.05
39%
-35
- C11 -
-
2FMN
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
46
PsiBlast_CBE
81.00
38%
-33
- C11 -
-
3FSU
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
30
PsiBlast_CBE
80.99
39%
-28
- C11 -
-
1B5T
1
METF_ECOLI
B:
[5-272]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
-----
G
K
P
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
40
PsiBlast_CBE
80.95
39%
-31
- C11 -
-
2FMO
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
31
PsiBlast_CBE
80.91
39%
-31
- C11 -
-
1ZRQ
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
10
PsiBlast_PDB
80.80
39%
-39
- C11 -
-
2FMO
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
-----
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
11
PsiBlast_PDB
80.74
39%
-29
- C11 -
-
3FST
1
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
-----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
38
PsiBlast_CBE
80.62
39%
-36
- C11 -
-
1ZP4
2
METF_ECOLI
B:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
33
PsiBlast_CBE
80.61
39%
-33
- C11 -
-
1ZPT
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
-------------
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
52
HHSearch
80.56
38%
-29
* C11 *
-
1B5T
1
METF_ECOLI
A:
[1-272]
--
G
Q
I
N
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
--
R
T
H
S
I
I
K
G
I
K
D
R
T
-
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
S
------
G
K
P
E
M
----
Y
A
S
D
L
V
T
L
L
K
E
-
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
39
PsiBlast_CBE
80.55
39%
-37
- C11 -
-
2FMO
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
-
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
41
PsiBlast_CBE
80.52
39%
-33
- C11 -
-
2FMN
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
V
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
8
PsiBlast_PDB
80.42
39%
-35
- C11 -
-
1ZP4
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
-------
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
G
--------
P
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
37
PsiBlast_CBE
80.05
39%
-35
- C11 -
-
1ZP4
2
METF_ECOLI
C:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
-----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
29
PsiBlast_CBE
79.67
39%
-31
- C11 -
-
1B5T
1
METF_ECOLI
C:
[5-272]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
-----------------
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
45
PsiBlast_CBE
79.45
38%
-41
- C11 -
-
3FSU
2
METF_ECOLI
E:
[25-292]
------
V
-
S
F
Q
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
P
----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
--
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
43
PsiBlast_CBE
79.32
39%
-35
- C11 -
-
3FST
1
METF_ECOLI
E:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
-------------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
53
HHSearch
78.46
37%
-24
- C11 -
-
3FST
2
METF_ECOLI
C:
[22-292]
---
Q
I
N
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
--
H
S
I
I
K
G
I
K
D
R
T
-
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
--------------
E
M
----
Y
A
S
D
L
V
T
L
L
K
E
-
V
A
-
D
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
7
PsiBlast_PDB
77.88
39%
-32
- C11 -
-
1ZRQ
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
G
A
-----
D
R
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
-----------
E
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---
6
PsiBlast_PDB
76.94
39%
-43
- C11 -
-
1ZPT
2
METF_ECOLI
A:
[25-292]
------
V
-
S
F
E
F
F
P
P
R
T
S
E
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
--
V
S
V
T
Y
---------
T
H
S
I
I
K
G
I
K
D
-
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
---------------
M
-----
Y
A
S
D
L
V
T
L
L
K
E
V
A
D
--
F
D
I
S
V
A
A
Y
P
E
V
H
P
E
A
K
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
F
A
D
M
T
N
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
D
M
V
K
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
---