@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1369: (2016-03-24 )
MTKSRFFSDVAETSSFVFAVAGADDEVVLETIRLALKQKLGKFLLFGKKEDKTLTANESVTWIQTDTAEAAAQGAILAVKNKEADILVKGFIPTATLMHHVLKKENGLRTDQLLSQIAIFDIPTYHKPLLITDCAMNVAPKTKEKIAITENALAVAHQIGITNPKIALLSAVEEVTAKMPSTLEAQEVVQHFGNQISVSGPLALDVAISKEAALHKGITDSSAGEADILIAPNIETGNALYKSLVYFAGAKVGSAVVGAKVPIVISSRNDSPENKLASFILTVRLVEK
Atome Classification :
(20 SA)
---------------------------------.........10...--......20....-----....30..-----.....--.40-........-------.50..------.-----...--.----.-----------------60.----.----...---.------.----------------------------.---------------------------70........80....----....90.-.-.-.-...-.---100.....-----..110--...--.--....120..----.-....130..----.----------..-...140...-----....150......-.160.......170---.---.--...---.---.---.-180-.---.---....---...190--------------------------..--..--..-------..200.......210.......220.......230.......240.......250........260----.........-------------270--.......280.-----.....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------M
T
K
S
R
F
F
S
D
V
-
A
ET--S
S
F
V
F
A
VAGAD
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
--
G
K
F
L
L
FGK-------KED
K
T
------L-----TAN--E----
S
-----------------
V
T
W
----
I
----QTD---
T
------
A
----------------------------
E
---------------------------
A
AAQ
G
A
I
L
A
V
KNKEA
D
----
I
L
V
K
GFI-
P
-
T
-
A
-
T
L
M
-
H
---
H
V
L
K
KENG-----L
R
T
D
---
Q
L
L
--
S
--
Q
I
AIFDIPT----Y-HK
P
L
L
-
I
T
D----C----------AM-NVAPKTK
E
K
-----
I
A
IT
E
N
A
L
A
V
A
H
Q-IGITN
P
K
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L
L
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A
----
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---
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A
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A
ISK
E
A
A
L
HKGITDSSAGEA
D
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APNIET
G
N
A
L
Y
K
S
L
V
Y
F
AGAK-VG
S
A
VVGAK------
V
P
I
V
I
SSRN-------------DS
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
LVEK---
16
HHSearch
99.78
100%
-126
- C1 -
3UF6
1
?
A:
[6-290]
-----------------------------------
K
S
R
F
F
S
D
V
-
A
E
T
--
S
S
F
V
F
A
V
A
G
A
D
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
--
G
K
F
L
L
F
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K
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K
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D
K
T
------
L
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----
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T
W
----
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---------------------------
A
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K
N
K
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----
I
L
V
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I
-
P
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T
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A
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T
L
M
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H
---
H
V
L
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K
E
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G
-----
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---
Q
L
L
--
S
--
Q
I
A
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I
P
T
----
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-
H
K
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L
L
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T
D
----
C
----------
A
M
-
N
V
A
P
K
T
K
E
K
-----
I
A
I
T
E
N
A
L
A
V
A
H
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
----
V
---
E
--
E
V
T
---
A
---
K
---
M
-
P
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S
---
T
---
L
E
A
Q
---
E
V
V
Q
H
---------------------------
F
G
--
N
Q
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I
S
-------
V
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P
L
A
L
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A
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A
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S
A
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N
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Y
K
S
L
V
Y
F
A
G
A
K
-
V
G
S
A
V
V
G
A
K
------
V
P
I
V
I
S
S
R
N
-------------
D
S
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
L
V
E
----
3
PsiBlast_PDB
99.37
98%
-126
- C1 -
3UF6
1
?
A:
[6-290]
-----------------------------------
K
S
R
F
F
S
D
V
-
A
E
T
--
S
S
F
V
F
A
V
A
G
A
D
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
--
G
K
F
L
L
F
G
K
-------
K
E
D
K
T
------
L
-----
T
A
N
--
E
----
S
-----------------
V
T
W
----
I
----
Q
T
D
---
T
------
A
----------------------------
E
---------------------------
A
A
A
Q
G
A
I
L
A
V
K
N
K
E
A
D
----
I
L
V
K
G
F
I
-
P
-
T
-
A
-
T
L
M
-
H
---
H
V
L
K
K
E
N
G
-----
L
R
T
D
---
Q
L
L
--
S
--
Q
I
A
I
F
D
I
P
T
----
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-
H
K
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L
L
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D
----
C
----------
A
M
-
N
V
A
P
K
T
K
E
K
-----
I
A
I
T
E
N
A
L
A
V
A
H
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
----
V
---
E
--
E
V
T
---
A
---
K
---
M
-
P
---
S
---
T
---
L
E
A
Q
---
E
V
V
Q
H
---------------------------
F
G
--
N
Q
--
I
S
-------
V
S
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P
L
A
L
D
V
A
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A
A
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K
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S
S
A
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A
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L
I
A
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N
I
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N
A
L
Y
K
S
L
V
Y
F
A
G
A
K
-
V
G
S
A
V
V
G
A
K
------
V
P
I
V
I
S
S
R
N
-------------
D
S
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
L
V
E
----
1
PsiBlast_PDB
98.68
98%
-124
- C1 -
3TNG
7
?
A:
[5-291]
----------------------------------
T
K
S
R
F
F
S
D
V
-
A
E
T
--
S
S
F
V
F
A
V
A
G
A
D
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
--
G
K
F
L
L
F
G
K
-------
K
E
D
K
T
------
L
-----
T
A
N
--
E
----
S
-----------------
V
T
W
----
I
----
Q
T
D
---
T
------
A
----------------------------
E
---------------------------
A
A
A
Q
G
A
I
L
A
V
K
N
K
E
A
D
----
I
L
V
K
G
F
I
-
P
-
T
-
A
-
T
L
M
-
H
---
H
V
L
K
K
E
N
G
-----
L
R
T
D
---
Q
L
L
--
S
--
Q
I
A
I
F
D
I
P
T
----
Y
-
H
K
P
L
L
-
I
T
D
----
C
----------
A
M
-
N
V
A
P
K
T
K
E
K
-----
I
A
I
T
E
N
A
L
A
V
A
H
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
----
V
---
E
--
E
V
T
---
A
---
K
---
M
-
P
---
S
---
T
---
L
E
A
Q
---
E
V
V
Q
H
---------------------------
F
G
--
N
Q
--
I
S
-------
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
S
L
V
Y
F
A
G
A
K
-
V
G
S
A
V
V
G
A
K
------
V
P
I
V
I
S
S
R
N
-------------
D
S
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
L
V
E
K
---
2
PsiBlast_PDB
98.55
98%
-125
- C1 -
3U9E
13
?
A:
[5-290]
----------------------------------
T
K
S
R
F
F
S
D
---
E
T
--
S
S
F
V
F
A
V
A
G
A
D
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
--
G
K
F
L
L
F
G
K
-------
K
E
D
K
T
------
L
-----
T
A
N
--
E
----
S
-----------------
V
T
W
----
I
----
Q
T
D
---
T
------
A
----------------------------
E
---------------------------
A
A
A
Q
G
A
I
L
A
V
K
N
K
E
A
D
----
I
L
V
K
G
F
I
-
P
-
T
-
A
-
T
L
M
-
H
---
H
V
L
K
K
E
N
G
-----
L
R
T
D
---
Q
L
L
--
S
--
Q
I
A
I
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D
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T
----
Y
-
H
K
P
L
L
-
I
T
D
----
C
----------
A
M
-
N
V
A
P
K
T
K
E
K
-----
I
A
I
T
E
N
A
L
A
V
A
H
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
----
V
---
E
--
E
V
T
---
A
---
K
---
M
-
P
---
S
---
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---
L
E
A
Q
---
E
V
V
Q
H
---------------------------
F
G
--
N
Q
--
I
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-------
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
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G
N
A
L
Y
K
S
L
V
Y
F
A
G
A
K
-
V
G
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A
V
V
G
A
K
------
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P
I
V
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S
S
R
N
-------------
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S
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
L
V
E
----
29
Fugue
96.99
99%
-121
- C1 -
3TNG
7
?
A:
[5-291]
----------------------------------
T
K
S
R
F
F
S
D
V
-
A
E
T
--
S
S
F
V
F
A
V
A
G
A
D
D
-----
E
V
V
L
E
T
I
R
-----
L
A
L
K
Q
--
K
L
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F
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L
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-----
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E
----
S
-----------------
V
T
W
----
I
----
Q
T
D
---
T
------
A
----------------------------
E
---------------------------
A
A
A
Q
G
A
I
L
A
V
K
N
K
E
A
D
----
I
L
V
K
G
F
I
-
P
-
T
-
A
-
T
L
-
M
H
---
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V
L
K
K
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-----
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R
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A
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----
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D
----
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----------
A
-M
N
V
A
P
K
T
K
E
K
-----
I
A
I
T
E
N
A
L
A
V
A
H
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
----
V
---
E
--
E
V
T
-------
A
---
K
M
P
---
S
---
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---
L
E
A
Q
---
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V
V
Q
H
---------------------------
F
G
--
N
Q
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-------
V
S
G
P
L
A
L
D
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A
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E
A
A
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T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
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T
G
N
A
L
Y
K
S
L
V
Y
F
A
G
A
K
-
V
G
S
A
V
V
G
A
K
------
V
P
I
V
I
S
S
R
N
-------------
D
S
P
--
E
N
K
L
A
S
F
I
L
T
V
-----
R
L
V
E
K
---
15
HHSearch
77.45
42%
-104
- C1 -
1YCO
1
?
A:
[1-275]
--------------------------------------------------
M
I
T
V
S
I
A
G
G
S
Q
-----
P
E
I
L
Q
L
V
K
-----
K
A
L
K
E
--
A
E
Q
P
L
Q
F
I
V
F
D
T
-------
N
E
N
L
D
-------------
T
E
--
N
----
L
-----------------
W
K
Y
----
V
----
H
C
S
---
D
------
E
----------------------------
A
---------------------------
A
V
A
Q
E
A
V
S
L
V
A
T
G
Q
A
Q
----
I
L
L
K
G
I
I
-
Q
-
T
-
H
-
T
L
L
-
K
---
E
M
L
K
S
E
H
Q
-----
L
K
N
K
---
P
I
L
--
S
--
H
V
A
M
V
E
L
P
A
------
G
K
T
F
L
-
L
T
D
----
C
----------
A
M
-
N
I
A
P
T
Q
A
T
L
-----
I
E
I
V
E
N
A
K
E
V
A
Q
K
-
L
G
L
H
H
P
K
I
A
L
L
S
A
----
A
---
E
--
N
F
N
---
P
---
K
---
M
-
P
---
S
---
S
---
V
L
A
K
---
E
V
T
A
H
---------------------------
F
N
DQ
Q
E
--
A
T
-------
V
F
G
P
L
S
L
D
L
A
T
S
E
E
A
V
A
H
K
R
Y
S
G
P
I
M
G
D
A
D
I
L
V
V
P
T
I
D
V
G
N
C
L
Y
K
S
L
T
L
F
G
H
A
K
-
V
G
G
T
I
V
G
T
K
------
V
P
V
V
L
T
S
R
S
-------------
D
S
T
--
E
S
K
F
H
S
L
R
F
A
M
-----
R
Q
V
H
H
---
4
PsiBlast_PDB
76.48
42%
-104
- C1 -
1YCO
1
?
A:
[5-273]
------------------------------------------------------
S
I
A
G
G
S
Q
-----
P
E
I
L
Q
L
V
K
-----
K
A
L
K
E
AE
Q
P
--
L
Q
F
I
V
F
D
T
-------
N
E
N
--------
L
-----
D
T
E
--
N
----
L
-----------------
W
K
Y
----
V
----
H
C
S
---
D
------
E
----------------------------
A
---------------------------
A
V
A
Q
E
A
V
S
L
V
A
T
G
Q
A
Q
----
I
L
L
K
G
I
I
-
Q
-
T
-
H
-
T
L
L
-
K
---
E
M
L
K
S
E
H
Q
-----
L
K
N
K
---
P
I
L
--
S
--
H
V
A
M
V
E
L
P
A
----
G
--
K
T
F
L
-
L
T
D
----
C
----------
A
M
-
N
I
A
P
T
Q
A
T
L
-----
I
E
I
V
E
N
A
K
E
V
A
Q
K
-
L
G
L
H
H
P
K
I
A
L
L
S
A
----
A
---
E
--
N
F
N
---
P
---
K
---
M
-
P
---
S
---
S
---
V
L
A
K
---
E
V
T
A
H
---------------------------
F
N
--
D
Q
QE
A
T
-------
V
F
G
P
L
S
L
D
L
A
T
S
E
E
A
V
A
H
K
R
Y
S
G
P
I
M
G
D
A
D
I
L
V
V
P
T
I
D
V
G
N
C
L
Y
K
S
L
T
L
F
G
H
A
K
-
V
G
G
T
I
V
G
T
K
------
V
P
V
V
L
T
S
R
S
-------------
D
S
T
--
E
S
K
F
H
S
L
R
F
A
M
-----
R
Q
V
-----
18
HHSearch
67.67
22%
-91
- C1 -
2AF4
2
PTAS_METTE
C:
[3-329]
-------------------------------------
T
F
L
E
K
I
S
E
R
A
KK
L
N
K
T
I
A
L
P
E
T
E
D
-----
I
R
T
L
Q
A
A
A
-----
K
I
L
E
R
--
G
I
--
A
D
I
V
L
V
G
N
-------
E
A
D
I
K
ALAG--
D
-----
L
D
L
--
S
----
K
-----------------
A
K
I
----
V
----
D
P
K
---
T
------
Y
EKKDEYINAFYELRKHKGITLENAAEIM
S
---------------------------
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
----
G
V
V
S
G
A
A
-
H
-
S
-
S
S
D
T
L
-
R
---
P
A
V
Q
-
I
V
K
-----
T
A
K
G
A--
A
L
A
--
S
--
A
F
F
I
I
S
V
P
D
CEYG
S
-
D
G
T
F
L
-
F
A
D
----
S
----------
G
M
-
V
E
M
P
S
V
E
D
V
-----
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
V
Q
D
V
P
K
V
A
M
L
S
Y
----
S
---
T
--
K
G
S
---
A
---
K
---
S
-
K
LTE
A
---
T
---
I
A
S
T
---
K
L
A
Q
E
---------------------------
L
A
--
P
D
--
I
A
-------
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
------
K
P
I
N
D
L
S
R
G
-------------
C
S
D
--
E
D
I
V
G
A
V
A
I
T
C
-----
V
Q
A
A
----
20
HHSearch
64.99
20%
-91
- C1 -
1TD9
6
PTAS_BACSU
A:
[10-328]
--------------------------------------
L
F
S
T
V
Q
E
K
V
AG
K
D
V
K
I
V
F
P
E
G
L
D
-----
E
R
I
L
E
A
V
S
-----
K
L
A
G
N
--
K
V
--
L
N
P
I
V
I
G
N
-------
E
N
E
I
Q
A
K
A
K
E
L
N
-----
L
T
L
--
G
----
G
-----------------
V
K
I
----
Y
----
D
P
H
---
T
------
Y
EG
M
E
D
L
V
Q
A
F
V
E
R
R
K
GKAT
E
E
Q
A
R
K
A
L
-
L
---------------------------
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
----
G
L
V
S
G
A
A
-
H
-
S
T
A
-
D
T
V
-
R
---
P
A
L
Q
-
I
I
K
-----
T
K
E
G
V--
K
K
T
--
S
--
G
V
F
I
M
A
R
G
-------
E
E
Q
Y
V
-
F
A
D
----
C
----------
A
I
-
N
I
A
P
D
S
Q
D
L
-----
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
D
I
-
E
P
R
V
A
M
L
S
F
----
S
---
T
--
K
G
S
AKS
D
---
E
---
T
-
E
---
K
---
V
---
A
D
A
V
---
K
I
A
K
E
---------------------------
K
A
--
P
E
--
L
T
-------
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
------
M
P
V
N
D
L
S
R
G
-------------
C
N
A
--
E
D
V
Y
N
L
A
L
I
T
A
-----
A
Q
A
-----
19
HHSearch
63.76
23%
-87
- C1 -
1VMI
2
EUTD_ECOLI
A:
[14-335]
--------------------------------------
I
I
E
R
C
R
E
L
A
LR
A
P
A
R
V
V
F
P
D
A
L
D
-----
Q
R
V
L
K
A
A
Q
-----
Y
L
H
Q
Q
--
G
L
--
A
T
P
I
L
V
A
N
-------
P
F
E
L
R
Q
F
A
L
S
H
G
-----
V
A
M
--
D
----
G
-----------------
L
Q
V
----
I
----
D
P
H
---
G
------
N
----------------------------
L
A
M
R
E
E
F
A
H
R
W
L
A
R
AGEKTPPD
A
L
E
K
L
T
D
P
L
M
F
A
A
A
M
V
S
A
G
K
A
D
----
V
C
I
A
G
N
L
-
S
S
T
-
A
-
N
V
L
-
R
---
A
G
L
R
-
I
I
G
-----
L
Q
P
G
C--
K
T
L
--
S
--
S
I
F
L
M
-
L
P
Q
----
Y
S
G
P
A
L
G
-
F
A
D
----
C
----------
S
V
-
V
P
Q
P
T
A
A
Q
L
-----
A
D
I
A
L
A
S
A
E
T
W
R
A
I
T
G
E
-
E
P
R
V
A
M
L
S
F
----
S
---
S
--
N
G
S
---
A
---
R
---
H
-
P
---
C
V
A
N
V
---
Q
Q
A
T
---
E
I
V
R
E
---------------------------
R
A
--
P
K
--
L
V
-------
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
R
A
V
G
P
L
I
Q
G
L
A
------
A
P
M
H
D
L
S
R
G
-------------
C
S
V
--
Q
E
I
I
E
L
A
L
V
A
A
-----
V
P
R
-----
6
PsiBlast_PDB
54.25
26%
-65
- C1 -
1VMI
2
EUTD_ECOLI
A:
[123-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
A
G
K
A
D
----
V
C
I
A
G
N
L
-
S
S
T
-
A
-
N
V
L
-
R
A
G
L
R
I
I
G
L
Q
P
G
-----
C
K
T
------
L
--
S
--
S
I
-
F
L
M
L
P
Q
----
Y
-
S
G
P
A
L
G
F
A
D
----
C
----------
S
V
-
V
P
Q
P
T
A
A
Q
L
-----
A
D
I
A
L
A
S
A
E
T
W
R
A
-
I
T
G
E
E
P
R
V
A
M
L
S
F
----
S
---
S
--
N
G
S
---
A
---
R
---
H
-
P
---
C
---
V
---
A
N
V
Q
Q
A
T
E
I
V
R
E
---------------------------
R
A
--
P
K
--
L
V
-------
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
R
A
V
G
P
L
I
Q
G
L
A
------
A
P
M
H
D
L
S
R
G
-------------
C
S
---------------------------
7
PsiBlast_PDB
50.42
23%
-76
- C1 -
1TD9
4
PTAS_BACSU
A:
[157-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
F
I
M
A
R
----
G
-
E
E
Q
Y
V
-
F
A
D
----
C
----------
A
I
-
N
I
A
P
D
S
Q
D
L
-----
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
D
I
-
E
P
R
V
A
M
L
S
F
----
S
---
T
--
K
G
S
---
A
---
K
---
S
-
D
---
E
---
T
E
K
V
A
D
A
V
---
K
I
A
K
E
---------------------------
K
A
--
P
E
--
L
T
-------
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
------
M
P
V
N
D
L
S
R
G
-------------
C
N
A
--
E
D
----------------------
8
PsiBlast_PDB
49.51
23%
-73
- C1 -
1XCO
3
PTAS_BACSU
A:
[157-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
F
I
M
A
R
----
G
-
E
E
Q
Y
V
-
F
A
D
----
C
----------
A
I
-
N
I
A
P
D
S
Q
D
L
-----
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
D
I
-
E
P
R
V
A
M
L
S
F
----
S
---
T
--
K
G
S
---
A
---
K
---
S
-
D
---
E
---
T
E
K
V
A
D
A
V
---
K
I
A
K
E
---------------------------
K
A
--
P
E
--
L
T
-------
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
------
M
P
V
N
D
L
S
R
G
-------------
C
N
A
--
E
D
----------------------
25
HHSearch
49.36
14%
-83
- C1 -
1YXO
8
PDXA1_PSEAE
A:
[2-325]
--------------------------------------------------
S
L
R
F
A
L
T
P
G
E
P
AGI
G
P
D
L
C
L
L
L
A
R
-----
S
A
Q
-----
P
--
H
P
L
I
A
I
A
S
-------
R
T
L
L
Q
E
-----
R
A
G
Q
L
G
L
A
I
--
D
L
K
--
D
V
S
PAAWPERPAKAG
Q
--
L
Y
V
----
W
----
D
T
P
L
A
A
P
------
V
R
PGQLDRAN
A
A
Y
V
---------------
L
---------------------------
E
T
L
T
R
A
G
Q
G
C
L
D
G
H
F
A
----
G
M
I
T
A
P
V
-
H
-
K
-
G
-
V
I
N
-
E
---
A
G
I
P
F
-
S
G
------
H
T
E
F
L
A
D
L
T
HT
A
--
Q
V
V
M
M
L
A
T
R
----
G
-
L
R
V
A
L
-
A
T
T
HLPL
R
----------
E
V
-
A
D
A
I
S
D
E
R
L
-----
T
R
V
A
R
I
L
H
A
D
L
R
D
K
F
G
I
A
H
P
R
I
L
V
C
G
L
NPHA
G
EGG
H
--
L
G
R
---
E
---
E
---
I
-
E
---
V
---
I
---
E
P
C
L
---
E
R
L
R
G
-------------------------------
E
G
--
L
D
-------
L
I
G
P
L
P
A
D
T
L
F
T
P
K
H
--------
L
-
E
-
H
C
D
A
V
L
A
M
Y
H
D
Q
G
L
P
V
L
K
Y
K
G
F
G
A
A
V
----
N
V
T
L
G
L
--------
P
I
I
R
T
S
V
D
HGTALDLAGSGR-
I
D
S
--
G
S
L
Q
V
A
L
E
T
A
Y
-----
Q
M
A
A
----
37
Fugue
48.78
25%
-37
- C1 -
4FYP
1
VSP1_ARATH
A:
[34-261]
----------------------------G
L
S
I
N
Y
P
N
C
R
S
W
H
L
G
-
V
E
T
--
S
N
I
I
N
---------------
F
D
T
V
P
-----
A
N
C
K
A
--
Y
V
--
E
D
Y
L
I
---------------------------
T
S
K
--
Q
----
Y
-----------------
Q
Y
D
----
S
----
K
T
V
---
N
------
K
----------------------------
E
---------------------------
A
Y
F
Y
A
K
G
L
A
L
K
N
D
T
V
-------------------------------------------------------
N
V
W
I
F
D
L
D
---------------
D
----
T
----------
L
L
-
S
S
I
P
Y
Y
A
K
Y
-----
G
Y
G
T
E
N
------------
T
A
P
G
A
Y
W
S
W
----
L
---
E
S
G
E
S
T
---
P
---
G
---
L
-
P
---
E
---
T
---
L
H
L
Y
---
E
N
L
L
E
---------------------------
L
G
I
-
E
P
--
I
I
-------
I
S
D
R
W
K
K
L
S
E
V
T
V
E
N
L
K
A
V
G
V
T
K
W
---
K
H
L
I
L
K
P
N
G
S
K
L
T
Q
V
V
Y
K
S
K
V
R
N
S
L
V
K
-
K
G
Y
N
I
V
G
N
I
------
G
D
Q
W
A
D
L
V
E
-------------
D
T
P
G
R
V
F
K
L
P
N
P
L
Y
Y
V
-----
P
S
L
E
H
H
H
H
26
HHSearch
47.92
16%
-80
- C1 -
3TSN
4
PDXA_CAMJE
A:
[3-365]
-------------------------------------------------
A
M
K
K
L
A
I
S
I
G
D
I
NSI
G
L
E
I
L
V
R
S
H
E
-----
E
L
S
----
K
I
--
C
T
P
F
Y
F
I
H
-------
E
S
L
L
N
K
A
L
K
L
L
N
-----
L
K
L
F
-
N
A
K
I
V
A
F
K
D
D
K
D
Y
E
F
N
F
I
KKENS
L
E
I
Y
S
F
C
L
PLGF
K
V
D
---
E
------
N
F
---------------------------
E
I
Q
A
GEID
A
K
S
G
L
Y
G
F
------------
L
S
F
K
A
A
S
Y
F
V
Y
E
K
H
A
H
----
A
L
L
T
L
P
I
-
H
-
K
-
K
-
A
W
E
-
D
---
A
G
L
K
Y
-
K
G
------
H
T
D
A
L
R
D
F
F
--
K
K
-
N
A
I
M
M
L
G
C
K
----
E
-
L
F
V
G
L
-
F
S
E
HIPL
A
----------
K
V
-
S
K
K
I
T
F
K
N
L
-----
S
I
F
L
K
D
F
Y
K
E
------
T
H
F
K
K
M
G
L
L
G
F
NPHA
G
DYG
V
--
I
G
G
---
E
---
E
---
E
-
K
---
I
---
M
---
E
K
A
I
---
A
F
V
N
A
F
L
H
S
KKD
E
K
F
F
K
K
A
L
K
D
E
N
L
Q
K
E
L
L
L
N
F
K
G-
K
G
--
V
Y
-------
L
P
Y
P
L
V
A
D
T
A
F
T
K
T
G
L
----------
K
N
C
N
R
L
V
A
M
Y
H
D
L
A
L
A
P
L
K
A
L
Y
F
D
K
S
I
----
N
V
S
L
N
L
--------
P
I
I
R
V
S
V
D
HGTAFDKAYKNAK
I
N
T
--
K
S
Y
F
E
A
A
K
F
A
I
-----
N
L
H
S
----
12
PsiBlast_PDB
47.27
26%
-64
- C1 -
4E4R
6
PTAS_STAAR
A:
[166-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
F
G
D
----
C
----------
A
I
-
N
P
E
L
D
S
Q
G
L
-----
A
E
I
A
V
E
S
A
K
S
A
L
S
-
F
G
-
M
D
P
K
V
A
M
L
S
F
----
S
---
T
--
K
G
S
---
A
---
K
---
S
-
D
---
D
---
V
---
T
K
V
Q
---
E
A
V
K
L
---------------------------
A
Q
--
Q
K
--
A
E
E
E
KLE
A
I
I
D
G
E
F
Q
F
D
A
A
I
V
P
G
V
A
E
K
K
A
P
G
A
K
L
Q
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
D
A
V
G
P
V
L
Q
G
L
N
------
S
P
V
N
D
L
S
R
G
-------------
C
S
I
--
E
D
----------------------
23
HHSearch
47.17
13%
-76
- C1 -
3LXY
3
PDXA_YERPE
A:
[7-330]
-------------------------------------------------
H
N
N
R
L
V
I
T
P
G
E
P
AGV
G
P
D
L
A
I
T
L
A
Q
-----
Q
D
-----
W
P
--
V
E
L
V
V
C
A
D
-------
P
A
L
L
L
A
R
A
S
Q
L
N
-----
L
P
L
Q
L
R
----
E
YQADQPAIAQQAG
S
---
L
T
I
----
L
----
P
V
K
---
T
A-----
V
N
V
V
PGKLDVGN
S
H
Y
V
-------------
V
---------------------------
E
T
L
A
K
A
C
D
G
A
I
S
G
E
F
A
----
A
L
V
T
G
P
V
-
Q
-
K
-
S
-
I
I
N
-
D
---
A
G
I
P
F
-
I
G
------
H
T
E
F
F
A
D
R
S
--
H
CQ
R
V
V
M
M
L
A
T
E
----
E
-
L
R
V
A
L
-
A
T
T
HLPL
L
----------
A
V
-
P
G
A
I
T
Q
A
S
L
-----
H
E
V
I
T
I
L
D
N
D
L
K
T
K
F
G
I
T
Q
P
Q
I
Y
V
C
G
L
NPHA
G
EGG
H
--
M
G
H
---
E
---
E
---
I
-
D
---
T
---
I
---
I
P
A
L
---
N
T
L
R
Q
-------------------------------
Q
G
--
I
N
-------
L
I
G
P
L
P
A
D
T
L
F
Q
P
K
Y
--------
L
-
Q
-
H
A
D
A
V
L
A
M
Y
H
D
Q
G
L
P
V
L
K
Y
Q
G
F
G
R
A
V
----
N
I
T
L
G
L
--------
P
F
I
R
T
S
V
D
HGTALELAATGT-
A
D
V
--
G
S
F
I
T
A
L
N
L
A
I
-----
K
M
I
N
----
32
Fugue
44.32
20%
-64
- C2 -
4ZOX
-
SQT1_YEAST
A:
[3-381]
MSNNSL
T
Y
F
D
KHTDSVF
A
I
G
H
H
PNLP
L
V
C
T
G
GG
D
N
L
A
H
L
W
T
S
H
-
S
Q
P
--
P
K
F
A
G
T
L
T
G
Y
G
E
-----
S
V
I
S
C
S
F
T
SEGG
F
L
V
T
A
D
--
M
S
--
G
K
V
L
V
H
M
G
Q
KGGAQW
K
L
A
S
Q
------
M
-----
Q
E
V
--
E
----
E
-----------------
I
V
W
----
L
----
K
T
H
---
P
TIAR
T
F
A
----------------------------
F
---------------------------
G
A
T
D
G
S
V
W
C
Y
Q
I
N
E
Q
D
G
S
L
E
Q
L
M
S
G
F
V
H
Q
-
Q
-
D
-
C
S
M
-
G
---
E
F
I
N
T
D
K
G
ENT
L
E
L
V
T
C
---
S
L
D
--
S
--
T
I
V
A
W
N
C
F
T
----
G
-
Q
Q
L
F
K
-
I
T
Q
----
A
EIKGLEAPWI
S
L
-
S
L
A
P
E
T
L
T
K
GNS
G
V
V
A
C
G
S
N
N
G
L
L
A
V
I
-
N
C
N
N
G
G
A
I
L
H
L
S
T
----
V
---
I
--
E
L
K
---
P
EQD
E
---
L
-
D
---
A
---
S
---
I
E
S
I
---
S
W
S
S
K
---------------------------
F
S
--
L
M
A
-
I
G
-------
L
V
C
G
E
I
L
L
Y
D
T
S
A
W
R
V
R
H
K
F
V
L
E
D
S
---
V
T
K
L
M
F
D
N
D
D
L
F
A
S
C
I
N
G
K
V
Y
Q
F
N
A
R
-
T
G
Q
E
K
F
V
C
V
GHNMGV
L
D
F
I
L
L
H
P
V
-------------
A
N
T
--
G
T
E
Q
K
R
K
V
I
T
A
G
DEG
V
S
L
V
F
E
V
P
N
17
HHSearch
43.79
23%
15
* C1 *
1R5J
-
?
A:
[2-327]
----------------------------------
S
I
R
S
L
F
G
G
L
R
E
K
I
LG
K
N
M
K
I
V
F
P
E
G
N
D
-----
E
R
V
V
R
A
A
A
-----
R
L
K
F
E
--
G
L
--
L
E
P
I
I
L
G
Q
-------
S
E
E
V
R
N
L
L
T
K
L
G
-----
F
A
D
--
Q
----
D
-----------------
Y
T
I
----
I
----
N
P
N
---
E
------
Y
----------------------------
A
DF
D
K
M
K
E
A
F
V
E
V
RKGKAT
L
E
D
A
D
K
M
L
R
D
V
N
Y
F
G
V
M
L
V
K
M
G
L
A
D
----
G
M
V
S
G
A
I
-
H
-
S
T
A
-
D
T
V
-
R
---
P
A
L
Q
-
I
I
K
-----
T
K
P
G
I--
S
R
T
--
S
--
G
V
F
L
M
N
R
E
N
----
T
-
S
E
R
Y
V
-
F
A
D
----
C
----------
A
I
-
N
I
D
P
T
A
Q
E
L
-----
A
E
I
A
V
N
T
A
E
T
A
K
I
-
F
D
I
-
D
P
K
I
A
M
L
S
F
----
S
---
T
--
K
G
S
---
G
---
K
A
P
Q
V
-
D
---
K
---
V
---
R
E
A
T
---
E
I
A
T
G
---------------------------
L
N
--
P
D
--
L
A
-------
L
D
G
E
L
Q
F
D
A
A
F
V
P
E
T
A
A
I
K
A
P
D
S
A
V
A
G
Q
A
N
T
F
V
F
P
D
L
Q
S
G
N
I
G
Y
K
I
A
Q
R
L
G
M
F
D
A
I
G
P
I
L
Q
G
L
N
------
K
P
V
N
D
L
S
R
G
-------------
S
S
A
--
E
D
I
Y
K
L
A
I
I
T
A
-----
A
Q
A
I
----