@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2545: (2016-04-04 )
MRIRVPATTANLGPGFDSCGLALTLYLTLDIGAEADSWYIEHNIGGGIPHDETNVIIETALNLAPNLTPHHLVMTCDIPPARGLGSSSAAVVAGIELANTLAELNLSKEEKVRIAAEIEGHPDNVAPAVLGNWVVGAKLDGEDFYVRHLFPDCALIAFIPKAELLTSESRGVLPDTLPFKEAVQASSIANVMIAAILRNDMTLAGEMMERDLWHEKYRSQLVPHLAQIRDVAKNQGAYAACLSGAGPTVLVFAPRNLANKLQTSLQTLEIDADVLLLDVEGSGAEVFR
Atome Classification :
(20 SA)
--.........10----.-----------..-----...---.-.20--....-.-....30.-------.-..-.-...40...--.--------.-----.-----.----------.--50-........60......-----.---..70----.........80........90.......-----------------.100.......110......------.------120-----.--------..-......130--..---......140........--150---...--.--....160.----.-....-.-170....---------------------..------------------------------.---180.....-..190.......200.......210--......------.---220.........230..---....--.240....--...250.-----...-...260..-...-.----.270.......280......--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
R
I
RVPATTAN----L-----------GP-----GFD---S-CG---
L
A
L
T
-
L
-
Y
L
T
L
DIG-------A-EA-D-
S
W
Y
I
EHNI--G--------G-----G-----I----------P--HD-ET
N
V
I
I
E
T
A
-
L
NLAPN-----L---TP
H
-----
H
L
V
M
T
CDIPPARGLGSS
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
LNLSKE
E
K
V
R
I
A
A
E
I------E------G-------H--------PD-NV
A
P
A
V
LG---N
W
---
V
V
G
A
K
LDG-E
D
F
Y
V
R
HL--F-P---D
C
A
--
L
--
I
A
FIP
K
A
E
----L-LTSE-S-RGVLPDT---------------------L
P
------------------------------
F
---
K
E
A
V
Q
A
S
S
-
I
A
N
V
M
I
A
A
I
L
RN
D
M
T
L
A
G
E
M
M
E
R
D
L
--
W
H
E
K
Y
R
------
S
---
Q
--
L
V
P
H
L
A
Q
I
R
D
V
A
KN---QG
A
Y
--
A
A
C
LSGAG--
P
T
V
L
V
FA-----
P
R
N
-
L
A
N
K
L
Q
T
S
-
L
Q
T
-
L
----
E
IDA
D
V
L
L
L
DVEGSGAEVFR--------------
1
PsiBlast_PDB
98.63
99%
-133
- C1 -
3HUL
2
KHSE_LISMO
A:
[3-290]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
-
L
-
Y
L
T
L
D
I
G
-------
A
-
E
A
-
D
-
S
W
Y
I
E
H
N
I
--
G
--------
G
-----
G
-----
I
----------
P
--
H
D
-
E
T
N
V
I
I
E
T
A
-
L
N
L
A
P
N
-----
L
---
T
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
-------
H
--------
P
D
-
N
V
A
P
A
V
L
G
---
N
W
---
V
V
G
A
K
L
D
G
-
E
D
F
Y
V
R
H
L
--
F
-
P
----
C
A
--
L
--
I
A
F
I
P
K
A
E
----
L
-
L
----------
P
D
T
---------------------
L
P
------------------------------
F
---
K
E
A
V
Q
A
S
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
L
--
W
-----------
S
---
Q
--
L
V
P
H
L
A
Q
I
R
D
V
A
K
N
---
Q
G
A
Y
--
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
-----
P
R
N
-
L
A
N
K
L
Q
T
S
-
L
Q
T
-
L
----
E
I
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
--------------
18
HHSearch
98.11
97%
-133
- C1 -
3HUL
2
KHSE_LISMO
A:
[3-290]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
-
L
-
Y
L
T
L
D
I
G
-------
A
E
A
D
---
S
W
Y
I
E
H
N
I
--
G
--------
G
-----
G
-----
I
----------
P
--
H
D
-
E
T
N
V
I
I
E
T
A
-
L
N
L
A
P
N
-----
L
---
T
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
-------
H
--------
P
D
-
N
V
A
P
A
V
L
G
---
N
W
---
V
V
G
A
K
L
D
G
-
E
D
-
F
Y
V
R
H
L
-
F
-
P
----
C
A
--
L
--
I
A
F
I
P
K
A
E
----
L
-
L
----------
P
D
T
---------------------
L
P
------------------------------
F
---
K
E
A
V
Q
A
S
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
L
--
W
-----------
S
---
Q
--
L
V
P
H
L
A
Q
I
R
D
V
A
K
N
---
Q
G
A
Y
--
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
-----
P
R
N
-
L
A
N
K
L
Q
T
S
-
L
Q
T
-
L
----
E
I
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
--------------
17
PsiBlast_CBE
94.75
99%
-131
- C1 -
3HUL
2
KHSE_LISMO
B:
[3-290]
--
L
R
I
R
V
P
A
T
T
A
N
----
L
-----------
G
P
-----
G
F
D
---
S
-
C
G
---
L
A
L
T
-
L
-
Y
L
T
L
D
I
G
-------
A
-
E
A
-
D
-
S
W
Y
I
E
H
N
I
----------------------------------
P
--
H
D
-
E
T
N
V
I
I
E
T
A
-
L
N
L
A
P
N
-----
L
---
T
P
H
-----
H
L
V
M
T
C
D
I
P
P
A
R
G
L
G
S
S
S
A
A
V
V
A
G
I
E
L
A
-----------------
N
T
L
A
E
L
N
L
S
K
E
E
K
V
R
I
A
A
E
I
------
E
------
G
-------
H
--------
P
D
-
N
V
A
P
A
V
L
G
---
N
W
---
V
V
G
A
K
L
D
G
-
E
D
F
Y
V
R
H
L
--
F
-
P
---
D
C
A
--
L
--
I
A
F
I
P
K
A
E
----
L
-
L
----------
P
D
T
---------------------
L
P
------------------------------
F
---
K
E
A
V
Q
A
S
S
-
I
A
N
V
M
I
A
A
I
L
R
N
D
M
T
L
A
G
E
M
M
E
R
D
L
--
W
--------------------
P
H
L
A
Q
I
R
D
V
A
K
N
---
Q
G
A
Y
--
A
A
C
L
S
G
A
G
--
P
T
V
L
V
F
A
-----
P
R
N
-
L
A
N
K
L
Q
T
S
-
L
Q
T
-
L
----
E
I
D
A
D
V
L
L
L
D
V
E
G
S
G
A
E
V
F
R
--------------
19
HHSearch
69.85
29%
-96
- C1 -
1H72
3
KHSE_METJA
C:
[3-295]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
E
P
-
Y
D
V
I
E
V
E
-------
A
I
D
D
-
K
-
E
I
I
I
E
V
D
---
D
--------
K
-----
N
-----
I
----------
P
T-
D
P
-
D
K
N
V
A
G
I
V
A
-
K
K
M
I
D
D
FNI--
G
---
K
G
V
-----
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
E
P
--
L
E
V
L
H
I
P
--
I
-
D
F--
K
L
D
--
I
--
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
----
K
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
D
-
Y
------
Y
E
N
T
I
R
T
E
V
-
G
K
G
V
E
V
----------------
43
Fugue
66.27
28%
-93
- C1 -
1H74
2
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
E
P
-
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
I
E
V
D
--
D
--------
K
-----
N
-----
I
----------
P
--
T
D
P
D
K
N
V
A
G
I
V
A
-
K
K
M
I
D
D
-----
F
---
N
I
G
K
G
V
--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
------
L
A
S
SGAK-
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
E
P
-
L
E
V
L
H
I
P
I
--
D
-
F
---
K
L
D
--
I
--
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
D
-
Y
-------
Y
E
N
T
I
R
T
E
V
G
K
G
V
E
V
V
---------------
42
Fugue
65.59
28%
-91
- C1 -
1FWK
1
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
E
P
-
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
I
E
V
D
--
D
--------
K
-----
N
-----
I
----------
P
--
T
D
P
D
K
N
V
A
G
I
V
A
-
K
K
M
I
D
D
-----
F
---
N
I
G
K
G
V
--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
E
P
-
L
E
V
L
H
I
P
I
--
D
-
F
---
K
L
D
--
I
--
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
----
K
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
D
-
Y
-------
Y
E
N
T
I
R
T
E
V
G
K
G
V
E
V
V
---------------
41
Fugue
64.80
28%
-91
* C1 *
1H72
3
KHSE_METJA
C:
[1-296]
MK
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
E
P
-
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
I
E
V
D
--
D
--------
K
-----
N
-----
I
----------
P
--
T
D
P
D
K
N
V
A
G
I
V
A
-
K
K
M
I
D
D
-----
F
---
N
I
G
KGV--
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
E
P
-
L
E
V
L
H
I
P
I
--
D
-
F
---
K
L
D
--
I
--
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
D
-
Y
----
Y
E
N
T
I
R
T
E
V
---
G
K
G
V
E
V
V
---------------
44
Fugue
63.45
26%
-101
- C1 -
1H72
3
KHSE_METJA
C:
[1-296]
MK
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
----V
F
G
---
L
C
L
K
E
P
-
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
I
E
V
D
--
D
--------
K
-----
N
-----
I
----------
P
--
T
D
-
P
D
K
N
V
A
G
I
V
-
A
K
K
M
I
D
-----
D
---
F
N
-IGKGV
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
-----------------
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
ELASSG
A
------
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
----
E
P
L
E
V
L
H
--
I
-
P
IDF
K
L
D
--
I
--
L
I
A
I
P
N
--ISIN
T
-
K
E
A
R
-
E
-
I
--
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
---VY
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
D
-
Y
YE----------------------NTIRTEVGKGVEVV
2
PsiBlast_PDB
61.23
28%
-94
- C1 -
4RPF
1
KHSE_YERPN
A:
[3-306]
--
V
K
I
Y
A
P
A
S
I
G
N
----
V
-----------
S
V
-----
G
F
D
---
V
-
L
G
---
A
A
V
S
-
P
-
I
D
G
T
L
L
G
D
C
V
S
V
T
A
A
-
E
R
-
F
-
S
L
H
N
E
G
R
F
--
V
--------
S
-----
K
-----
L
----------
P
--
D
D
P
K
Q
N
I
V
Y
Q
C
W
-
E
R
F
C
Q
E
-----
M
G
K
E
I
P
V
-----
A
M
V
L
E
K
N
M
P
I
G
S
G
L
G
S
S
A
C
S
V
V
A
G
L
M
A
M
-----------------
N
E
F
C
G
Q
P
L
D
K
V
T
L
L
G
M
M
G
E
L
------
E
------
G
R
V
SGSI-
H
--------
F
D
-
N
V
A
P
C
Y
L
G
---
G
M
---
Q
L
--
I
L
E
Q
-
E
G
Y
I
S
Q
D
V
P
G
F
-
S
---
D
W
L
--
W
--
V
M
A
Y
P
G
I
K
----
V
-
S
T
A
E
-
A
-
R
A
I
L
P
A
Q
---------------------
Y
R
------------------------------
R
---
Q
D
C
I
T
H
G
R
-
N
L
A
G
F
I
H
A
C
H
T
Q
Q
P
D
L
A
A
K
M
M
-
K
D
V
--
I
A
E
P
Y
R
------
T
---
Q
--
L
L
P
G
F
A
A
A
R
Q
A
A
Q
D
---
I
G
A
L
--
A
C
G
I
S
G
S
G
--
P
T
L
F
A
V
C
ND
Q
A
T
A
Q
R
-
M
A
G
W
L
Q
N
H
Y
L
Q
N
-
D
----
E
G
F
V
H
I
C
R
L
D
T
A
G
A
--------------------
29
HHSearch
59.66
17%
-107
- C1 -
2CZ9
3
GAL1_PYRHO
A:
[2-350]
--
I
K
V
K
S
P
G
R
V
N
L
----
I
-----------
G
E
HTDYT
Y
G
Y
---
V
-
M
P
---
M
A
I
N
-
L
-
Y
T
K
I
E
A
E
-------
K
H
G
----
E
V
I
L
Y
S
E
H
--
F
--------
G
E
E
R
K
F
S
LNDLR
K
----------
E
--
N
S
-
W
I
D
Y
V
K
G
I
F
-
W
V
L
K
E
S
D
Y
E
--
V
---
G
G
I
-----
K
G
R
V
S
G
N
L
P
L
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
-----------------
D
K
L
Y
N
L
K
L
D
S
L
S
K
V
L
L
A
K
K
A
------
E
------
N
-------
E
FVGVPCGI
L
D
-
Q
F
-
A
V
V
F
G
REG
N
V
---
I
F
L
D
T
H
T
L
---
D
Y
E
Y
I
P
--
F
P
K
---
D
V
S
--
I
--
L
V
F
Y
T
G
V
R
---------
S
S
E
-
Y
A
E
R
K
H
I
A
E
E
S
L
K
I
L
GKGSSKEVREGEL
S
K
LP
P
L
H
R
K
F
----------------------
F
---
G
Y
I
V
R
E
N
A
-
R
V
L
E
V
R
D
A
L
K
E
G
N
V
E
E
V
G
K
I
L
-
T
T
A
---
H
W
D
L
A
------
K
NYE
V
--
S
C
K
E
L
D
F
F
V
E
R
A
L
K
---
L
G
A
Y
--
G
A
R
L
T
G
A
G
FG
G
S
A
I
A
L
V
-----
D
K
E
-
D
A
E
T
I
G
E
E
-
I
L
R
E
Y
L
K
R
F
P
W
K
A
R
H
F
I
V
E
P
-
S
D
G
V
G
I
----------------
26
HHSearch
58.70
20%
-112
- C1 -
2V8P
5
ISPE_AQUAE
A:
[5-269]
--
I
K
V
L
S
P
A
K
I
N
L
----
G
L
W
V
L-------
G
R
LPS--
G
Y
H
E
I
L
T
-
L
Y
---
Q
E
I
P
-
F
-
Y
D
E
I
Y
I
R
-------
E
G
V
-----
L
R
V
E
T
N
---
I
--------------
G
-----
I
----------
P
---
Q
-
E
E
N
L
V
Y
K
G
L
-
R
E
F
E
R
I
T
GI--
E
---
I
N
Y
-----
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
-----------------
N
E
L
L
G
S
P
L
S
E
E
E
L
R
E
L
V
G
S
I
------
S
------
A
-------------------
D
A
P
F
F
L
L
G
---
K
S
---
A
I
G
R
G
K
G
E
-
V
--
L
E
P
V
E
--
T
E
I
---
S
G
K
--
I
--
T
L
V
I
P
Q
V
S
----
S
-
S
T
G
R
-
V
-
Y
S
S
L
R
E
E
---------------------
H
F
------------------------------
V
--------
T
P
E
-
Y
A
E
E
K
I
Q
R
I
I
S
G
E
V
E
E
I
E
N
V
L
-
G
D
I
--
A
-----------
R
---
E
--
L
Y
P
E
I
N
E
V
Y
R
F
V
E
Y
---
L
G
-
F
--
K
P
F
V
S
G
S
G
--
S
T
V
Y
F
F
G
-----
G
A
S
-
E
E
--
L
K
K
A
-
A
K
M
-
R
------
G
W
K
V
V
E
L
-------------------------
36
HHSearch
57.56
19%
-93
- C1 -
1KKH
2
MVK_METJA
A:
[6-315]
--
M
I
I
E
T
P
S
K
V
I
L
----
F
-----------
G
E
H
A
V
V
Y
G
Y
R
---
A
-
I
S
---
M
A
I
D
-
L
-
T
S
T
I
E
I
K
-------
E
T
Q
E
-
D
-
E
I
I
L
N
L
N
D
--
L
N
K
S
L
G
L
N
L
N
-----
E
-----
I
KNIN------
P
NN
F
G
-
D
F
K
Y
C
L
C
A
I
-
K
N
T
L
D
Y
L
NIEP
K
---
T
G
F
-----
K
I
N
I
S
S
K
I
P
I
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
-----------------
S
G
F
Y
N
K
E
L
K
D
D
E
I
A
K
L
G
Y
M
V
------
E
------
K
E
I
Q
GKAS
I
--------
T
D
--
T
S
T
I
T
Y
K
---
G
I
---
L
E
I
K
N
N
K
F
R
K
I
K
G
E
F
E
E
--
F
L
K
---
N
C
K
--
F
--
L
I
V
Y
A
E
K
R
K---
K
-
K
T
A
E
-
L
-
V
N
E
V
A
K
I
---------------------
E
N
------------------------------
K
---
D
E
I
F
K
E
I
---
D
K
V
I
D
E
A
L
K
I
K
N
K
E
D
F
G
K
L
M
-
T
K
N
---
H
E
L
L
K
------
K
---
L
NI
S
T
P
K
L
D
R
I
V
D
I
G
N
R
---
F
G
-
F
--
G
A
K
L
T
G
A
G
GG
G
C
V
I
I
L
V
-----
N
E
E
-
K
E
K
E
L
L
K
E
-
L
N
K
-
E
------
D
V
R
I
F
N
C
R
M
-----------------------
6
PsiBlast_PDB
56.87
26%
-99
- C1 -
1H72
3
KHSE_METJA
C:
[3-278]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
-
E
P
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
---------------------------
I
----------
E
--
V
D
-
D
K
N
I
P
T
D
P
D
-
K
N
V
A
G
I
-----
V
---
A
K
K
--------
M
I
D
D
F
N
I
G
K
G
V
---
K
I
T
I
K
K
G
V
K
A
G
SGLGSSAASSAGTAYAI
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
LASSGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
---
E
P
L
E
V
L
H
I
--
P
-
I
---
D
F
K
--
L
DI
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
-----------------------------------------
30
HHSearch
55.98
18%
-100
- C1 -
2GS8
10
?
A:
[9-316]
--
I
T
V
T
S
Y
A
N
I
A
I
----
I
KYWGKENQAKM
I
P
-----
S
T
S
---
S
-
I
S
---
L
T
L
E
N
M
-
F
T
T
T
S
V
S
-------
F
L
P
D
T
A
T
S
D
Q
F
Y
I
N
G
--
I
--------------
L
-----
Q
----------
N
---
D
-
E
E
H
T
K
I
S
A
I
I
D
Q
F
R
Q
P
G----
Q
---
A
F
V
-----
K
M
E
T
Q
N
N
M
P
T
A
A
G
L
S
S
S
S
S
G
L
S
A
L
V
K
A
C
-----------------
D
Q
L
F
D
T
Q
L
D
Q
K
A
L
A
Q
K
A
K
F
A
------
S
------
G
-------
S
------------
S
S
R
S
F
F
G
---
P
V
---
A
A
W
D
K
D
S
G
-
A
--
I
Y
K
V
E
T
-
D
-
L
---
K
M
A
M
I
M
--
L
V
L
N
A
A
K
K
P---
I
S
S
R
E
G
-
M
-
K
L
C
R
D
T
S
---------------------
T
T
------------------------------
F
---
D
Q
W
V
E
Q
S
A
I
D
Y
Q
H
M
L
T
Y
L
K
T
N
N
F
E
K
V
G
Q
L
T
E
A
N
A
L
A
M
H
A
T
T
K
T
ANPPF
S
---
Y
--
L
T
K
E
S
Y
Q
A
M
E
A
V
K
E
L
R
Q
E
G
F
A
--
C
Y
F
T
M
D
A
G
--
P
N
V
K
V
L
C
-----
L
E
K
-
D
L
A
Q
L
A
E
R
-
L
G
K
-
N
-------
Y
R
I
I
V
S
K
T
-
K
D
L
P
D
-----------------
8
PsiBlast_PDB
55.88
26%
-98
- C1 -
1H73
2
KHSE_METJA
A:
[3-278]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
-
E
P
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
---------------------------
I
----------
E
--
V
D
-
D
K
N
I
P
T
D
P
D
-
K
N
V
A
G
I
-----
V
---
A
K
K
--------
M
I
D
D
F
N
I
G
K
G
V
---
K
I
T
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
SSGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
---
E
P
L
E
V
L
H
I
--
P
-
I
---
D
F
K
--
L
D
I
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
-----------------------------------------
7
PsiBlast_PDB
55.53
26%
-99
- C1 -
1H74
2
KHSE_METJA
A:
[3-278]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
-
E
P
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
---------------------------
I
----------
E
--
V
D
-
D
K
N
I
P
T
D
P
D
-
K
N
V
A
G
I
-----
V
---
A
K
K
--------
M
I
D
D
F
N
I
G
K
G
V
---
K
I
T
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
---
E
P
L
E
V
L
H
I
--
P
-
I
---
D
F
K
--
L
D
I
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
-----------------------------------------
24
HHSearch
55.03
18%
-95
- C1 -
1WUU
3
GALK1_HUMAN
A:
[37-397]
--
L
A
V
S
A
P
G
R
V
N
L
----
I
-----------
G
E
HTDYN
Q
G
L
---
V
-
L
P
---
M
A
L
E
-
L
-
M
T
V
L
V
G
S
-------
P
R
K
D
-
G
-
L
V
S
L
L
T
T
S
EG
A
DEP-----
Q
R
L
---
Q
F
P
---
L
P
T
AQ
R
S
L
E
PG
T
--
P
R
-
W
A
N
Y
V
K
G
V
I
-
Q
Y
Y
P
A
A
P----
L
---
P
G
F
-----
S
A
V
V
V
S
S
V
P
L
G
G
G
L
S
S
S
A
S
L
E
V
A
T
Y
T
F
L
-----------------
Q
Q
L
C
P
D
S
G
T
I
A
A
R
A
Q
V
C
Q
Q
A
------
E
------
H
S
FAGMP-
C
--------
G
I
M
D
Q
F
I
S
L
M
G
---
Q
K
GHA
L
L
I
D
C
R
S
L
-
E
T
S
L
V
P
L
S
--
D
-
P
---
K
L
A
--
V
--
L
I
T
N
S
N
V
R
----
H
---
A
S
-
S
E
Y
P
V
R
R
R
Q
---------------------
C
E
E
V
A
R
A
L
GKESLREVQ
L
E
E
L
E
A
A
RDLVS
K
E
G
F
R
R
A
R
H
V
V
G
E
I
R
-
R
T
A
Q
A
A
A
A
L
R
R
G
D
Y
R
A
F
G
R
L
M
-
V
E
S
---
H
R
S
L
R
DDY---
E
---
V
--
S
C
P
E
L
D
Q
L
V
E
A
A
L
A
V--
P
G
V
Y
--
G
S
R
M
T
G
G
G
F
G
G
C
T
V
T
L
L
-----
E
A
S
-
A
A
P
H
A
M
R
H
-
I
Q
E
H
Y
----
G
G
T
A
T
F
Y
L
S
Q
-
A
A
D
G
A
K
V
L
---------------
20
HHSearch
54.92
21%
-94
- C1 -
3PYF
1
ISPE_MYCTU
A:
[6-300]
--
V
T
V
R
V
P
G
K
V
N
L
Y
L
A
V
G
-----------
D
R
RED--
G
Y
H
---
E
-
L
T
T
V
F
H
A
V
S
-
L
-
V
D
E
V
T
V
R
-------
N
A
D
V
-
L
-
S
L
E
L
V
G
E
G
--
A
--------
D
-----
Q
-----
L
----------
P
--
T
D
-
E
R
N
L
A
W
Q
A
A
-
E
L
M
A
E
H
V
GR--
A
---
P
D
V
-----
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
-----------------
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
------
G
------
S
-------------------
D
V
P
F
A
L
H
G
---
G
T
---
A
L
G
T
G
R
G
E
-
E
--
L
A
T
V
L
--
S
R
N
---
T
F
H
--
W
--
V
L
A
F
A
D
S
G
----
L
-
L
T
S
A
-
V
-
Y
N
E
L
D
R
L
---------------------
R
E
------------------------------
V
---
G
D
-
P
P
R
L
G
-
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
-
G
N
E
--
M
-
Q
A
A
A
------
V
---
S
--
L
D
P
A
L
A
R
A
L
R
A
G
V
E
---
A
G
A
L
--
A
G
I
V
S
G
S
G
--
P
T
C
A
F
L
C
-----
T
S
A
S
S
A
I
D
V
G
A
Q
-
L
S
G
-
A
----
G
V
C
R
T
V
R
V
A
T
G
P
V
P
G
A
R
V
V
---------------
5
PsiBlast_PDB
54.81
26%
-99
- C1 -
1FWL
-
KHSE_METJA
A:
[7-282]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
-
E
P
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
---------------------------
I
----------
E
--
V
D
-
D
K
N
I
P
T
D
P
D
-
K
N
V
A
G
I
-----
V
---
A
K
K
--------
M
I
D
D
F
N
I
G
K
G
V
---
K
I
T
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
---
E
P
L
E
V
L
H
I
--
P
-
I
---
D
F
K
--
L
D
I
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
-----------------------------------------
4
PsiBlast_PDB
54.62
26%
-96
- C1 -
1FWK
1
KHSE_METJA
A:
[3-278]
--
V
R
V
K
A
P
C
T
S
A
N
----
L
-----------
G
V
-----
G
F
D
---
V
-
F
G
---
L
C
L
K
-
E
P
Y
D
V
I
E
V
E
-------
A
-
I
D
-
D
-
K
E
I
I
---------------------------
I
----------
E
--
V
D
-
D
K
N
I
P
T
D
P
D
-
K
N
V
A
G
I
-----
V
---
A
K
K
--------
M
I
D
D
F
N
I
G
K
G
V
---
K
I
T
I
K
K
G
V
K
A
G
SGLG
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
------
E
L
A
S
SGA
K
-------
H
--------
A
D
-
N
V
A
P
A
I
F
G
---
G
F
---
T
M
V
T
N
Y
---
E
P
L
E
V
L
H
I
--
P
-
I
---
D
F
K
--
L
D
I
L
I
A
I
P
N
I
S
----
I
-
N
T
K
E
-
A
-
R
E
I
L
P
K
A
---------------------
V
G
------------------------------
L
---
K
D
L
V
N
N
V
G
-
K
A
C
G
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
S
D
K
--
V
I
E
P
V
R
------
G
---
K
--
L
I
P
N
Y
F
K
I
K
E
E
V
K
D
---
K
-
V
Y
--
G
I
T
I
S
G
S
G
--
P
S
I
I
A
F
P
-----
K
E
E
-
F
I
D
E
V
E
N
I
-
L
R
-----------------------------------------