Atome 2 Filter

@TOME V2.3
(Nov 2016)

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Sequence color : MutatedHelixStrandConserved

Query sequence : O52K1_HUMAN: (2016-01-12 )
MLPSNITSTHPAVFLLVGIPGLEHLHAWISIPFCFAYTLALLGNCTLLFIIQADAALHEPMYLFLAMLATIDLVLSSTTLPKMLAIFWFRDQEINFFACLVQMFFLHSFSIMESAVLLAMAFDRYVAICKPLHYTTVLTGSLITKIGMAAVARAVTLMTPLPFLLRRFHYCRGPVIAHCYCEHMAVVRLACGDTSFNNIYGIAVAMFIVVLDLLFVILSYVFILQAVLQLASQEARYKAFGTCVSHIGAILSTYTPVVISSVMHRVARHAAPRVHILLAIFYLLFPPMVNPIIYGVKTKQIREYVLSLFQRKNM

Atome Classification :

	(20 SA)									--------------.------------------...---------.....10........20.--.......30........40........50....---------....60..---......70........-80..----......90...--.....100.....----..110----....--...120......-------------.130.......140---------------.......150...---------------....160----...-.....170--.--......180.......190......--..---.200.---...--...210..---.....-220-..-----.......230-------------...-----------.--------------------..-...240.......250----...----....260...--...-.-270------..--.......-280..----..-...290.....--..300.......310..----------------------
		(Atome)	(Ident)	(Tito)	(Num)		(Ligand)	(Uniprot)		--------------M------------------LPS---------NITSTHPAVFLLVGIPGL--EHLHAWISIPFCFAYTLALLGNCTLLFIIQADA---------ALHEPMYL---FLAMLATIDLVLSSTT-LPKM----LAIFWFRDQEI--NFFACLVQMFFLH----SFSIM----ESAV--LLAMAFDRYVAI-------------CKPLHYTTVLTGSL---------------ITKIGMAAVARAV---------------TLMTPL-----PFL-LRRFHYCR--G--PVIAHCYCEHMAVVRLA--CGDTSF--NN---IYGIA---VAM--FIVVLDLL---FVILS-Y---VF-----ILQAVLQL---------------ASQ-----------E--------------------AR-YKAFGTCVSHIGAILS----TYT----PVVISSVMHR--VAR-H-A--------AP--RVHILLA-IFYLL----FP-PMVNPIIYGVK--TKQIREYVLSLFQRKNM----------------------
32	HHSearch	87.70	16%	-160	* C4 *	2Z73		OPSD_TODPA	A:[32-332]	------------------------------------------------------------------AVYYSLGIFIGICGIIGCGGNGIVIYLFTKTK---------SLQTPANM---FIINLAFSDFTFSLVNGFPLM----TISCFLKKWIF--GFAACKVYGFIGG----IFGFM----SIMT--MAMISIDRYNVI-------------GRPMAASKKMSHRR---------------AFIMIIFVWLWSV---------------LWAIGP-----IFG-WGAYTL--------EGVLCNCSFDYISR-------DST--TR---SNILC---MFI--LGFFGPIL---IIFFC-Y---FN-----IVMSVSNH---------------EKE-----------MAAMAKRLNAKELRKAQAGANAE-MRLAKISIVIVSQFLL----SWS----PYAVVALLAQ--FGP-LEW--------VT--PYAAQLP-VMFAK----AS-AIHNPMIYSVS--HPKFREAISQTFPWVLT----------------------
28	HHSearch	86.62	17%	-160	- C4 -	2KS9		NK1R_HUMAN	A:[34-324]	----------------------------------------------------------------------LWAAAYTVIVVTSVVGNVVVMWIILAHK---------RMRTVTNY---FLVNLAFAEASMAAFN-TVVN----FTYAVHNEWYY--GLFYCKFHNFFPI----AAVFA----SIYS--MTAVAFDRYMAI-------------IHPLQPRL--SATA---------------TKVVICVIWVLAL---------------LLAFPQ-----GYY-STTET---------MPSRVVCMIEWPEHP-----NKIY--EK---VYHIC---VTV--LIYFLPLL---VIGYA-Y---TV-----VGITLWAS---------------EIPGDSSDRYHEQVS--------------------AK-RKVVKMMIVVVCTFAI----CWL----PFHIFFLLPY--INP-D-LYL------KKFIQQVYLAI-MWLAM----SS-TMYNPIIYCCL--NDRFRLGFKHAFRCCPF----------------------
39	Fugue	86.30	16%	-152	- C4 -	1F88		OPSD_BOVIN	A:[1-348]	MNGTEGPNFYVPFSN------------------KTG---------VVRSPFEAPQYYLA---E--PWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHK---------KLRTPLNY---ILLNLAVADLFMVFGG-FTTT----LYTSLHGYFVF--GPTGCNLEGFFAT----LGGEI----ALWS--LVVLAIERYVVV-------------CKPMSNFRFGENHA---------------IMGVAFTWVMALA---------------CAAPPL-----VGW-SR--YIPE--G---------------MQCS--CGIDYY--TP---HEETN---NES--FVIYMFVV---HFIIP-L---IV-----IFFCYGQLVFTVKEAAASA----TTQ-----------K--------------------AE-KEVTRMVIIMVIAFLI----CWL----PYAGVAFYIF--THQGS-D--------FG--PIFMTIP-AFFAK----TS-AVYNPVIYIMM--NKQFRNCMVTTLCCGKNPSTTVSKTETSQVAPA------
19	PsiBlast_PDB	84.03	26%	-167	- C4 -	4GBR		ADRB2_HUMAN	A:[20-270]	-----------------------------------------------------------------------------------VFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AAHILTKTWTF--GNFWCE----FWT----SIDVLCVTASIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKNK------------------------ARVI---------------ILMVWIVSGLTSFL-PIQMHWYR--ATHQEAINCYAEE------T--CCDFFT--NQ---AYAIA---SSIVSFYVPLVIM---VFVYS-R---VF------QEAKRQL---------------QKI-----------DKFCL----------------KE-HKALKT----LGIIMG----TFTLCWLPFFIVNIVHV--IQD-NLI--------RK--EVYILLNWIGYV------N-SGFNPLIYCRS--PDFRIAFQELLCL--------------------------
8	PsiBlast_PDB	83.85	26%	-163	- C4 -	4QKX		ADRB2_HUMAN	A:[197-447]	-----------------------------------------------------------------------------------VFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AACILTKTWTF--GNFWCE----FWT----SIDVLCVTASIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKN------------------------KARVI---------------ILMVWIVSGLTSFL-PIQMHWYR--ATHQEAINCYAEE------T--CCDFFT--NQ---AYAIA---SSIVSFYVPLVIM---VFVYS-R---VFQEAKRQLQ---KF---------------ALK-----------E-----------------------HKALKT----LGIIMG----TFTLCWLPFFIVNIVHV--IQD-NLI--------RK--EVYILLNWIGYV------N-SGFNPLIYCRS--PDFRIAFQELLCL--------------------------
41	Fugue	83.65	16%	-151	- C4 -	1U19		OPSD_BOVIN	A:[4-349]	-----MNGTEGPNFY------------------VPF---------SNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHK---------KLRTPLNY---ILLNLAVADLFMVFGG-FTTT----LYTSLHGYFVF--GPTGCNLEGFFAT----LGGEI----ALWS--LVVLAIERYVVV-------------CKPMSNFRFGENHA---------------IMGVAFTWVMALA---------------CAAPPL-----VGW-SR--YIPE--G---------------MQCS--CGIDYY--TP---HEETN---NES--FVIYMFVV---HFIIP-L---IV-----IFFCYGQLVFTVKEAAAQQQESATTQ-----------K--------------------AE-KEVTRMVIIMVIAFLI----CWL----PYAGVAFYIF--THQGS-D--------FG--PIFMTIP-AFFAK----TS-AVYNPVIYIMM--NKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
17	PsiBlast_PDB	83.47	26%	-159	- C4 -	4LDL		ADRB2_HUMAN	A:[197-447]	-----------------------------------------------------------------------------------VFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AAHILTKTWTF--GNFWCE----FWT----SIDVLCVTASIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKN------------------------KARVI---------------ILMVWIVSGLTSFL-PIQMHWYR--ATHQEAINCYAEE------T--CCDFFT--NQ---AYAIA---SSIVSFYVPLVIM---VFVYS-R---VFQEAKRQLQ---KF---------------ALK-----------E-----------------------HKALKT----LGIIMG----TFTLCWLPFFIVNIVHV--IQD-NLI--------RK--EVYILLNWIGYV------N-SGFNPLIYCRS--PDFRIAFQELLCL--------------------------
18	PsiBlast_PDB	83.46	26%	-158	- C4 -	4LDO			A:[197-447]	-----------------------------------------------------------------------------------VFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AAHILTKTWTF--GNFWCE----FWT----SIDVLCVTASIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKN------------------------KARVI---------------ILMVWIVSGLTSFL-PIQMHWYR--ATHQEAINCYAEE------T--CCDFFT--NQ---AYAIA---SSIVSFYVPLVIM---VFVYS-R---VFQEAKRQLQ---KF---------------ALK-----------E-----------------------HKALKT----LGIIMG----TFTLCWLPFFIVNIVHV--IQD-NLI--------RK--EVYILLNWIGYV------N-SGFNPLIYCRS--PDFRIAFQELLCL--------------------------
16	PsiBlast_PDB	83.30	26%	-159	- C4 -	4LDE			A:[197-447]	-----------------------------------------------------------------------------------VFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AAHILTKTWTF--GNFWCE----FWT----SIDVLCVTASIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKN------------------------KARVI---------------ILMVWIVSGLTSFL-PIQMHWYR--ATHQEAINCYAEE------T--CCDFFT--NQ---AYAIA---SSIVSFYVPLVIM---VFVYS-R---VFQEAKRQLQ---KF---------------ALK-----------E-----------------------HKALKT----LGIIMG----TFTLCWLPFFIVNIVHV--IQD-NLI--------RK--EVYILLNWIGYV------N-SGFNPLIYCRS--PDFRIAFQELLCL--------------------------
31	HHSearch	79.41	16%	-143	- C4 -	1U19		OPSD_BOVIN	A:[41-326]	---------------------------------------------------------------------SMLAAYMFLLIMLGFPINFLTLYVTVQHK---------KLRTPLNY---ILLNLAVADLFMVFGG-FTTT----LYTSLHGYFVF--GPTGCNLEGFFAT----LGGEI----ALWS--LVVLAIERYVVV-------------CKPMSNFRF-GENH---------------AIMGVAFTWVMAL---------------ACAAPP-----LVG-WSRYIPE--------GMQCSCGIDYYTP-----HEETN--NE---SFVIY---MFV--VHFIIPLI---VIFFC-Y---GQ-----LVFTVKEA---------------AAQ-----------QQESATTQK------------AE-KEVTRMVIIMVIAFLI----CWL----PYAGVAFYIF--THQ-GSD--------FG--PIFMTIP-AFFAK----TS-AVYNPVIYIMM--NKQFRNCMVTTLCCGKN----------------------
29	HHSearch	79.09	17%	-158	- C4 -	2LNL	-	CXCR1_HUMAN	A:[38-323]	-------------------------------------------------------------------NKYVVIIAYALVFLLSLLGNSLVMLVILYSR---------VGRSVTDV---YLLNLALADLLFAL-T-LPIW----AASK-VNGWIF--GTFLCKVVSLLKE----VNFYS----GILL--LACISVDRYLAI-------------VHATRTLTQ-KRHL---------------VKFVCLGCWGLSM---------------NLSLPF-----FLF-RQAYHP--------NNSSPVCYEVLGND------TAKW--RM---VLRIL---PHT--FGFIVPLF---VMLFC-Y---GF-----TLRTLFKA---------------HM------------G--------------------QK-HRAMRVIFAVVLIFLL----CWL----PYNLVLLADT--LMR-T-QVIQESCERRNNIGRALDAT-EILGF----LH-SCLNPIIYAFI--GQNFRHGFLKILAMHG-----------------------
47	Fugue	77.21	20%	-173	- C1 -	3ES5	-	?	A:[42-420]	--------------MRLGWIDPLPQVDTIFPLGLEP---------NVESI-PAGEVELDF------NLPETIAKPF--ADTVTSVGDRIQL-VDDDKE---------NIATSIYG---LSFFKAARQLYSTMLD-HEKAVNQPLKAVYYDETPIPAHMSGALGIIGHMKTKVGDVLVK----DAGV--LFKRGTAAGVTKFSEIDNDKTWNLDCSKLVWADHSSLSM---------------IKRLASEKISQLVKQRYRVTDAQGHVYSVSMPQL-----TDQ-ALPDYYDS--I--PDVAP-NSDQLRVLTAALQMSLAQF--RNDELPHDED---RSD--LLTTLDLL---YADGA-YEISAL-----RDQFELLM---------------ARY-----------T--------------------TD-FKWRVESIFKVGPPPA----GTT----GYGAQTVSSTGNTAR-W-Q--------FP--LSDADIN-IGYLF----SP-SKSFSLFPKMVGYSKRAREDASASFANSDAKKFYAD----------------
25	HHSearch	75.43	20%	-173	- C4 -	3EML		ENLYS_BPT4	A:[22-222]	---------------------------------------------------------------------SVYITVELAIAVLAILGNVLVCWAVWLNS---------NLQNVTNY---FVVSLAAADIAVGVLA-IPFA----ITIST--GFCA--ACHGCLFIACFVL----VLTQS----SIFS--LLAIAIDRYIAI-------------RIPLRYNGLVTGTR---------------AKGIIAICWVLSF---------------AIGLTP-----MLG-WNNCGQ-----------SQGCGEGQ---VA--CLFEDVVPMN---YMVYF---NFF--ACVLVPLL---LMLGV-Y---LR-----IFLAARRQ---------------LNI-----------F--------------------EM-LRIDEGLRLKIYKDTE----GYY----TIGIGHLLTK--SPS-L-N--------AA--KSELDKA-IGRNT----NG-VITKDEAEKLF--NQDVDAAVRGILRNAKL----------------------
23	HHSearch	69.09	19%	-151	- C4 -	2RH1		ADRB2_HUMAN (first)	A:[40-236]	--------------------------------------------------------------------VVGMGIVMSLIVLAIVFGNVLVITAIAKFE---------RLQTVTNY---FITSLACADLVMGLAV-VPFG----AAHILMKMWTF--GNFWCEFWTSIDV----LCVTA----SIET--LCVIAVDRYFAI-------------TSPFKYQSLLTKNK---------------ARVIILMVWIVSG---------------LTSFLP-----IQMHWYRATHQ---------EAINCYA----EET--CCDFFT--NQ---AYAIA---SSI--VSFYVPLV---IMVFV-Y---SR-----VFQEAKRQ---------------LNI-----------F--------------------EM-LRIDEGLRLKIYKDTE----GYY----TIGIGHLLTK--SPS-L-N--------AA--KSELDKA-IGRNT----NG-VITKDEAEKLF--NQDVDAAVRGILRNAKL----------------------
21	HHSearch	68.24	19%	-170	- C4 -	3UON		ACM2_HUMAN (first)	A:[24-215]	---------------------------------------------------------------------VFIVLVAGSLSLVTIIGNILVMVSIKVNR---------HLQTVNNY---FLFSLACADLIIGVFS-MNLY----TLYTVIGYWPL--GPVVCDLWLALDY----VVSNA----SVMN--LLIISFDRYFCV-------------TKPLTYPVKRTTKM---------------AGMMIAAAWVLSF---------------ILWAPA-----ILF-WQFIVGVR------TVEDGECYIQFF-----------S--NA---AVTFG---TAI--AAFYLPVI---IMTVL-Y---WH-----ISRASKSR---------------INI-----------F--------------------EM-LRIDEGLRLKIYKDTE----GYY----TIGIGHLLTK--SPS-L-N--------AA--KSELDKA-IGRNT----NG-VITKDEAEKLF--NQDVDAAVRGILRNAKL----------------------
45	Fugue	67.60	15%	-179	- C2 -	5CQC		?	A:[22-402]	------------SIY------------------PPETSWEVNKGMNSSRLHKLYSLFFDKSSA--FYLGDDVSVLLTGAYGFQSKKNDQQIFLFRPDSDYVAGYHVDAKSDAGWVNDKLDRRLSEISEFCSKAT-QP----------------A--TFILPFVEMPTDI----TKGV-----QHQV--LLTISYDPKSKQ-------------LTPTVYDSIGRDTYSESLSSYFKGKYRTTCDEILTQSIEKAI---------------KSTDFT-----LGK-FTRAAYNTE-G--NCGSYTFRTIKEVISSS--AQGTTS--NS----YLTS---QHV--QDIESCIK---YRNLG-V---VD-----IESALTEG---------------KTL-----------P--------------------VQ-LSEFIVALEDYGKLRSQQYSKTA----KLTAVELLIG--ILN-D-IKGKNEIS-ES--QYDKLVK-EVDCLMDSSLG-KLVQFHLKNLG--AESLQKLVLPCVKFD------------------------
22	HHSearch	66.38	17%	-157	- C4 -	3RZE		ENLYS_BPT4 (first)	A:[10-201]	----------------------------------------------------------------------PLVVVLSTICLVTVGLNLLVLYAVRSER---------KLHTVGNL---YIVSLSVADLIVGAVV-MPMN----ILYLLMSKWSL--GRPLCLFWLSMDY----VASTA----SIFS--VFILCIDRYRSV-------------QQPLRYLKYRTKTR---------------ASATILGAWFLSF---------------LWVIPI-----L-G-WNH------------RREDKCETDFY-----------D--VT---WFKVM---TAI--INFYLPTL---LMLWF-Y---AK-----IYKAVRQH---------------CNI-----------F--------------------EM-LRIDEGLRLKIYKDTE----GYY----TIGIGHLLTK--SPS-L-N--------AA--KSELDKA-IGRNT----NG-VITKDEAEKLF--NQDVDAAVRGILRNAKL----------------------
20	PsiBlast_PDB	66.03	25%	-169	- C4 -	2VT4		ADRB1_MELGA	A:[102-283]	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LCVIAIDRYLAI-------------TSPFRYQSLMTRAR----------------AKVIICTVWAIS---------------ALVSFL-----PIM-M---HWWRDED--PQALKCYQDP------G--CCDFVT--NR---AYAIASSIISF--YIPLLIMI---FVALRVY---RE-----AKEQIR------------------------------------------------------EHKALKTLGIIMGVFTL----CWL----PFFLVNIVNV--FNR-D-L--------VP--D-WLFVA-FNWLG----YANSAMNPIIYCRS--PDFRKAFKRLLA---------------------------
44	Fugue	62.35	17%	-149	- C3 -	3W6S		?	A:[19-243]	-----------------------------------------------SIEWKLTANLRNGPTF--FQPLADSIEP--LQFKLIGSDTVATAFPVFDTK---------YIPDSLIN---YLFKLFNLEIESGKT--------------YPQLHSL--TKQGFLNYWFHSF----AVVVL----QTD---------EKFIQ---------------DNQDWNSVLLGTF---------------YIKPNYA------------------------------------PRCSHNCN--A--GFLVN---------------GAHRG--QK---VGYRL---AQV--YLNWAPLLGYKYSIFN-L---VF-----V-----------------------TN-----------Q--------------------AS-WKIWDK----------------------------LNF--QRI-G-L--------VP--HAGILNG----------FS-EPVDAIIYGKD--LTKIEPEFLSME---------------------------
13	PsiBlast_PDB	62.11	24%	-167	- C4 -	4EIY		AA2AR_HUMAN (first)	A:[24-191]	----------------------------------------------------------GAPPI--MGSSVYITVELAIA-VLAILGNVLVCWAVWLNS---------NLQNVTNY---FVVSLAAADIAVGVLA-IPFA----ITI------ST--GFCAACHGCLFIA----CFVLVLT--QSSIFSLLAIAIDRYIAI-------------RIPLRYNGLVTGTR---------------AK--GIIAICWVL---------------SFAIGL-----TPM-L-GWNNCG--Q--PKEGKNHSQGCGEGQVA--CLFEDV--VP---MNYMV---YFN--FFACVLVP---LLLML-G---VY-----LRIFLAAR---------------RQL-----------A--------------------DL-EDNWETLNDNLKVIEK----ADN----AAQVKDALTK--MRA-A-A--------LD--AQKMKDF-RHGFD----IL-VGQIDDALKLA--NEGKVKEAQAAAEQLKT----------------------