@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR3A2_HUMAN: (2016-01-13 )
MSLQKLMEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGGNLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRLLAICQPLTYSTRMSQTVQRMLVAASLACAFTNALTHTVAMSTLNFCGPNEVNHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPLVLIITAYSHVAAAVLRIRSVEGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEEASDKDKGVGVFNTVINPMLNPLIYSLRNPDVQGALWQIFLGRRSLT
Atome Classification :
(20 SA)
.....----..---..10........20.....----...30........40.----.......50-------.........60..----...---.-----------..70..-------......80.....---------...90-----------......----..-100.......110.......--.120--------......-------...130.......140.......150.......160---------..------------------------...-..170.......---------180.......190...--.----..----.-------200......-----.---210....--...220..----.....230.-----.-.....---240------------------....---------.....250-----------------.-------.......----260-........270.--.-.---.------...280------........--290-----------..--.--------...----..300-.....-------..310.......320----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
L
Q
K
----LM---EPEAGT
N
R
T
A
V
A
E
F
I
L
L
G
L----VQTEEM
Q
P
V
V
F
V
L
L
L
F
----
A
Y
L
VTTGG--------
N
L
S
I
L
A
A
V
LVEPK----LHA---
P
-----------
M
Y
F
F
LG-------N
L
S
V
L
D
V
G
C
I
T
V
T
---------
V
P
A
M
L
-----------
G
R
L
L
SH----KS-TI
S
Y
D
A
C
L
S
Q
L
-
F
F
F
H
L
L
AG--
M
D
----------
C
F
L
L
T
A
-------
M
A
Y
D
R
L
L
A
I
CQPLT
Y
S
T
R
M
S
Q
T
V
Q
R
M
L
V
A
A
S
L
A
C
A
F
---------
T
N
------------------------
A
L
T
-
H
T
V
A
M
S
T
LNFCG---------PNEVN
H
F
YCD
L
P
Q
L
F
Q
--L----SC----S-------S
T
Q
L
N
E
L
L
L
-----
F
---
A
V
G
F
I
MA--GT
P
L
V
L
I
I
----
T
A
Y
S
H
V
A
A
A
-----
V
-
L
R
I
RS---V--------------------E
G
R
K
---------
K
A
F
S
T
CG------------------
S
-------
H
L
T
V
V
C
L
----
F
F
--
G
R
G
I
F
N
Y
M
RLGS--E-E---A------SDKDK-------G
V
G
V
F
N
T
V
--
I
N
------------
P
M
--
L
--------
N
P
L
----
I
Y
SLR-NPDV
Q
-------
G
A
L
W
Q
I
F
LGRRSLT-----------------------------
17
PsiBlast_PDB
87.03
21%
-118
- C1 -
2Y03
9
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
--------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
15
PsiBlast_PDB
86.39
21%
-116
- C1 -
2Y01
12
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
D
P
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
14
PsiBlast_PDB
86.12
21%
-119
- C1 -
2Y00
13
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
16
PsiBlast_PDB
85.96
21%
-117
- C1 -
2Y02
13
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
19
PsiBlast_PDB
85.92
21%
-116
- C1 -
4AMJ
12
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
18
PsiBlast_PDB
85.76
21%
-115
- C1 -
2Y04
13
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
20
PsiBlast_PDB
85.39
21%
-118
- C1 -
3ZPQ
11
ADRB1_MELGA
A:
[7-294]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
35
HHSearch
85.05
15%
-128
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-332]
-----------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
----
C
G
I
I
G
C
G
G
--------
N
G
I
V
I
Y
L
F
T
K
T
K
S
----
L
Q
T
---
P
-----------
A
N
M
F
I
I
-------
N
L
A
F
S
D
F
T
F
S
L
V
N
G
--------
F
P
L
M
T
-----------
I
S
C
F
L
K
----
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
-
F
I
G
G
I
F
G
F
--
M
S
----------
I
M
T
M
A
M
-------
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
---------
L
W
------------------------
A
I
G
-
P
I
F
G
W
G
A
Y
T
L
-------------
E
G
V
L
C
N
C
S
F
D
Y
I
S
----------------------
R
D
S
T
T
R
S
N
I
-----
L
---
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
----
F
C
Y
F
N
I
V
M
S
-----
V
-
S
N
H
E
K
---
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
---------
R
L
A
K
I
S
I
------------------
V
-------
I
V
S
Q
F
L
L
----
S
W
--
S
P
Y
A
V
V
A
L
L
A
Q
F
--
G
-
P
LEW
V
------
T
P
Y
A
A
-------
Q
L
P
V
M
F
A
K
--
A
S
------------
A
I
--
H
--------
N
P
M
----
I
Y
S
V
S
-
H
P
K
F
R
-------
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-----------------------------
41
Fugue
84.84
15%
-120
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
PNF
Y
V
---
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
----
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
----
L
I
M
L
G
F
P
I
--------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
----
L
R
T
---
P
-----------
L
N
Y
I
L
L
-------
N
L
A
V
A
D
L
F
M
V
F
G
G
---------
F
T
T
T
L
-----------
Y
T
S
L
H
G
----
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
-
F
F
A
T
L
G
G
E
--
I
A
----------
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
---------
V
M
------------------------
A
L
A
-
C
A
A
P
P
L
-------------------
V
G
W
S
R
Y
I
P
E
G
M
Q
--
C
----
S
C
----
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
-----
I
---
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
----
F
C
Y
G
Q
L
V
F
T
-----
V
-
K
E
A
A
A
---
S
--------------------
A
T
T
Q
---------
K
A
E
K
E
V
T
------------------
R
-------
M
V
I
I
M
V
I
----
A
F
--
L
I
C
W
L
P
Y
A
G
V
A
F
--
Y
-
I
---
F
------
T
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
--
T
S
------------
A
V
--
Y
--------
N
P
V
----
I
Y
I
M
M
-
N
K
Q
F
R
-------
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------
9
PsiBlast_PDB
84.52
21%
-118
- C1 -
2VT4
8
ADRB1_MELGA
A:
[10-292]
------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
--------------------------------
E
H
-------
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
-----------------------------------
13
PsiBlast_PDB
82.64
21%
-118
- C1 -
2YCY
6
ADRB1_MELGA
A:
[10-292]
------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
--
D
R
---
A
--------------------
S
K
R
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
F
----------------------------------
45
Fugue
82.54
19%
-117
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------
S
F
K
C
A
--------
L
----
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
----
V
F
I
I
G
F
L
G
--------
N
S
V
A
I
W
M
F
V
F
H
M
K
----
P
W
S
---
G
-----------
I
S
V
Y
M
F
-------
N
L
A
L
A
D
F
L
Y
V
-
L
T
---------
L
P
A
L
I
-----------
F
Y
Y
F
N
K
----
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
-
F
I
F
H
V
N
L
Y
--
G
S
----------
I
L
F
L
T
C
-------
I
S
A
H
R
Y
S
G
V
V
Y
P
--------
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
---------
L
V
------------------------
W
L
I
-
V
V
V
A
I
S
P
I
L
F
Y
S
---------
G
T
G
V
R
K
---
N
K
T
I
T
C
Y
--
D
----
T
T
----
S
-------
D
E
Y
L
R
S
Y
F
I
-----
Y
---
S
M
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
----
G
C
Y
G
L
I
V
R
A
-----
L
-
I
Y
---------------------------
K
M
K
K
---------
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGT
D
-------
F
K
D
I
V
C
P
----
L
C
--
G
V
G
K
D
Q
F
E
E
V
E
E
--
P
-
L
---
R
------
R
K
S
I
Y
-------
L
V
I
I
V
L
T
V
--
F
A
------------
V
S
--
Y
--------
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
-------
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
49
Fugue
81.91
21%
-136
- C2 -
1YT3
11
RND_ECOLI
A:
[1-375]
M
N
Y
Q
M
----
I
T
T--
D
D
A
L
A
S
L
C
E
A
V
R
A
F
P
A
I
A
L
D
T
E
F
V
R
T
R
T
Y
Y
P
Q
L
G
L
I
Q
L
F
DGE
H
L
A
L
I
D
P
L
G
IT------
D
W
S
P
L
K
A
I
L
R
D
P
S
I
T
K
F
L
H
A
G
S
E
D
-----------
L
E
V
F
L
N
-------
V
F
G
E
L
P
Q
P
L
I
D
T
Q
---------
I
L
A
A
F
C
GRPMSWG
F
--
A
S
M
V
E
E
----
Y
S
-
G
V
T
L
D
K
S
E
S
R
T
D
W
L
A
R
P
L
T
E
--
R
Q
----------
C
E
Y
A
A
A
-------
D
V
W
-
Y
L
L
P
I
T
A
K
L
M
V
E
T
E
A
S
G
W
L
P
A
A
L
D
E
C
R
L
M
Q
M
R
---------
R
Q
E
V
V
A
PEDAWRDITNAWQLR
T
R
Q
L
A
C
L
Q
-
L
L
A
D
W
R
L
R
K
A
R
E
---------
R
D
L
A
V
N
F
V
V
R
E
E
H
L
W
S
--
V
----
A
R
Y
MPG
S
-------
L
G
E
L
D
S
L
G
L
-----
S
---
G
S
E
I
R
F
H
--
G
K
T
L
L
A
L
V
----
E
K
A
Q
T
L
P
E
D
ALPQP
M
-
L
N
L
M
D
---
M
--------------------
P
G
Y
R
---------
K
A
F
K
A
I
K
------------------
S
-------
L
I
T
D
V
S
E
----
T
H
--
K
--------
I
S
A
--
E
-
L
---
L
------
A
S
R
R
Q
-------
I
N
Q
L
L
N
W
H
W
K
L
K
------------
P
Q
NN
L
--------
P
E
L
----
I
S
G
W
R
-
G
E
L
M
A
-------
E
A
L
H
N
L
L
Q
E
Y
P
Q
-------------------------------
10
PsiBlast_PDB
81.90
21%
-115
- C1 -
2YCW
7
ADRB1_MELGA
A:
[7-292]
---------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
D
P
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
K
I
D
R
---
A
--------------------
S
K
R
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
F
----------------------------------
32
HHSearch
81.53
15%
-118
* C1 *
2KS9
1
NK1R_HUMAN
A:
[33-324]
--------------------------------------------
V
L
W
A
A
A
Y
T
V
----
I
V
V
T
S
V
V
G
--------
N
V
V
V
M
W
I
I
L
A
H
K
R
----
M
R
T
---
V
-----------
T
N
Y
F
L
V
-------
N
L
A
F
A
E
A
S
M
A
A
F
N
---------
T
V
V
N
F
-----------
T
Y
A
V
H
N
----
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
-
F
F
P
I
A
A
V
F
--
A
S
----------
I
Y
S
M
T
A
-------
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
---------
L
L
------------------------
A
F
P
-
Q
G
Y
Y
S
T
T
-
E
T
-------------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
-------------
P
-------
N
K
I
Y
E
K
V
Y
H
-----
I
---
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
----
Y
A
Y
T
V
V
G
I
T
-----
L
-
W
A
S
E
I
---
P
GDSSDRYH
E
Q
V
---------
S
A
K
R
---------
K
V
V
K
M
M
I
------------------
V
-------
V
V
C
T
F
A
I
----
C
W
--
L
P
F
H
I
F
F
L
L
P
Y
I
--
N
-
P
---
D
LYLKKF
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
--
S
S
------------
T
M
--
Y
--------
N
P
I
----
I
Y
C
C
L
-
N
D
R
F
R
-------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-----------------------------
12
PsiBlast_PDB
80.31
21%
-116
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[9-292]
-----------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
K
I
D
R
---
A
--------------------
S
K
R
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
R
L
L
A
F
----------------------------------
11
PsiBlast_PDB
79.60
21%
-115
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-292]
-----------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
----
V
V
L
L
I
V
A
G
--------
N
V
L
V
I
A
A
I
G
S
T
Q
R
----
L
Q
T
---
L
-----------
T
N
L
F
I
T
-------
S
L
A
C
A
D
L
V
V
G
L
L
V
---------
V
P
--
F
-----------
G
A
T
L
V
V
----
R
G
-
T
W
L
W
G
S
F
L
C
E
L
-
W
-----
T
S
--
L
D
----------
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
----------------------------------------------
V
W
A
I
S
A
L
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
--
C
Y
Q
DP
G
C
----
C
-------
D
F
V
T
N
R
A
Y
A
-----
I
---
A
S
S
I
I
S
F
--
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----
I
-
R
K
I
D
R
---
A
--------------------
S
K
R
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
------------------
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
I
V
N
V
F
------
N
-
R
---
D
------
L
V
P
D
W
-------
L
F
V
A
F
N
W
L
G
Y
A
N
------------
S
A
--
M
--------
N
P
I
----
I
Y
C
-
R
-
S
P
D
F
R
-------
K
A
F
K
---------------------------------------
46
Fugue
78.24
18%
-118
- C1 -
4QLA
1
HYEP_BOMMO
A:
[19-442]
L
D
L
E
E
----
W
W
GPP
E
L
K
Q
K
Q
D
T
S
I
K
P
F
E
I
T
F
S
E
----
T
M
V
K
E
L
K
E
R
I
K
K
R
R
P
F
----
A
P
P
L
E
G
V
G
FKYGFNSK
Q
L
D
S
W
L
K
Y
W
A
E
E
Y
----
P
F
A
---
E
-----------
R
Q
K
F
L
N
Q
Y
P
H
F
K
T
N
I
Q
G
L
N
I
H
F
M
R
I
T
P
K
V
P
KG
V
E
I
V
P
L
L
L
L
H
G
W
PGSVREF
Y
E
A
I
P
H
----
L
T
-
A
V
S
K
D
R
N
F
A
L
E
-
I
I
A
P
S
L
P
G
--
Y
G
F
S
D
A
A
VRPGL
A
A
A
E
V
A
-------
V
I
F
K
N
L
M
A
R
L
G
Y
K
Q
Y
Y
V
Q
G
G
D
--
W
G
A
L
I
G
S
A
M
A
T
F
F
PKEII
G
F
H
S
N
M
------------------------
A
L
T
-
L
S
P
A
A
T
F
L
E
F
V
G
A
L
FPSLIVE
P
E
L
A
N
R
L
Y
-
P
L
S
E
K
Y
S
--
T
----
L
L
----
E
-------
E
L
G
Y
M
H
I
Q
A
-----
T
K
P
D
T
V
G
I
G
L
T
--
D
S
P
A
G
L
L
A
----
Y
I
L
E
K
F
S
T
W
-----
T
N
P
D
L
R
S
---
K
--------------------
E
D
G
G
---------
L
S
Y
R
W
T
K
------------------
D
-------
Q
L
I
D
N
L
M
----
L
Y
W
S
T
K
S
I
V
T
S
M
R
L
Y
A
--
E
-
S
---
F
------
S
S
R
H
F
-------
D
L
K
L
D
E
I
Q
--
V
Q
V
P
T
W
V
L
Q
A
KHEL
A
Y
--
Q
--------
P
P
C
----
I
L
K
M
K
-
Y
P
K
L
V
N
A
S
V
I
ED
G
G
H
F
L
A
F
E
L
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N--------------
33
HHSearch
76.85
16%
-101
- C1 -
1U19
14
OPSD_BOVIN
A:
[38-326]
-----------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
----
L
I
M
L
G
F
P
I
--------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
----
L
R
T
---
P
-----------
L
N
Y
I
L
L
-------
N
L
A
V
A
D
L
F
M
V
F
G
G
---------
F
T
T
T
L
-----------
Y
T
S
L
H
G
----
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
-
F
F
A
T
L
G
G
E
--
I
A
----------
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---------
A
C
------------------------
A
A
P
-
P
L
V
G
W
S
R
Y
I
P
-------------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
-------------
H
-------
E
E
T
N
N
E
S
F
V
-----
I
---
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
----
F
C
Y
G
Q
L
V
F
T
-----
V
-
K
E
A
A
A
---
Q
QQESA
T
T
Q
------------
K
A
E
K
---------
E
V
T
R
M
V
I
------------------
I
-------
M
V
I
A
F
L
I
----
C
W
--
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
---
F
------
G
P
I
F
M
-------
T
I
P
A
F
F
A
K
--
T
S
------------
A
V
--
Y
--------
N
P
V
----
I
Y
I
M
M
-
N
K
Q
F
R
-------
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------------
44
Fugue
76.32
14%
-138
* C3 *
3ZPJ
-
?
A:
[1-356]
--
M
T
T
----
L
E
---
E
I
N
L
L
V
E
R
G
Y
Y
E
E
A
L
A
K
V
Y
----
E
I
E
D
P
I
E
Q
V
Q
V
L
T
K
I
V
----
V
T
I
Y
Q
H
D
G
--------
P
M
E
W
I
P
S
I
M
E
D
A
M
----
Y
I
A
---
K
K
LRD
P
A
N
K
A
V
A
Y
S
I
I
A
S
-------
T
L
A
I
M
E
Y
---
E
E
D
---------
A
M
D
F
F
-----------
N
R
A
I
D
E
A
N
E
I
E
S
-
P
I
E
K
G
M
V
L
S
T
L
-
A
Y
H
L
A
I
A
G
Y
P
D
N
----------
A
L
E
I
F
N
-------
I
A
F
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
L
P
S
---------
N
E
------------------------
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
H
---------
V
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
K
T
V
Y
----
D
V
----
G
-------
L
P
Q
I
R
A
A
L
L
K
GK
N
H
Y
---
A
L
A
I
I
K
K
--
K
Y
S
G
V
M
R
L
----
I
G
E
L
E
V
A
L
W
-----
M
-
K
R
V
N
N
ME
Y
L
--------------------
D
V
V
D
---------
K
A
F
E
C
C
E
------------------
S
PRFT
D
V
N
V
Q
H
I
A
R
L
----
L
T
--
E
L
G
N
L
R
R
A
L
K
F
A
--
K
-
E
---
I
------
Q
N
I
H
K
-------
R
S
E
A
L
K
A
I
--
A
L
------------
E
L
--
V
R
R
KKFEE
V
K
K
I
----
I
E
S
I
P
-
D
P
K
I
R
-------
E
E
A
L
N
E
I
G
T
I
E
--------------------------------