@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0101: (2015-11-28 )
MNEVVTFGCRLNFYESELIKEALRKAERENVVVVHSCAVTNEAERQVKQKIRKIYKNDPNKEIIVVGCAVQLDPESYSNIPGVSKVLGNQDKLKTENYLLSNNKILVNDNQASKSEPALIDKFKDKSRAFIEVQNGCDHSCTFCSITEARGNNRSVPINNIIEQIKIFVANGYQEVVFTGVDITDFGTDLFGKPSLGLMVRRVLKDVPELKRLRLSSIDVAEVDDELMDLIVNESRFMPHLHLSLQSGNNLILKRMKRRHSREQVIEFCHKVKSLRSNIAYGADIIAGFPTETDEMFQDTVNLLEETNTVYLHAFPYSKRKNTPAARMPQVPENVRKERVKNLRKINKAMMSNFYQSLIGTKQSVLVEQNNIGRAENFALVKFTSKIQAKSIVKATIIGMESGYLVGSIIP
Atome Classification :
(20 SA)
-..-.......10........20------.......--..--------30....-------....40........50------...--.--....60........70-.......-.80--------........90........100-.........110-------.........120.......130.---......140--------.....-..150------.---..-.....160........----170--------.........180--.-.......190.-......200....-.-.--.210--.....-.-.----..220----------.......230--.----------.....--..240.......250--------.....-..--.---.--260......-.270...----....280--..---.-...--.--.290--.---.......300......--.310.......320..-.....-330........340.......350-.........360.......370--.----.-------...-----...-.-----380----..-.....390.......400..-.....410------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MN-E
V
V
T
F
G
C
R
L
N
F
Y
E
S
E
L
I
K
-------
E
A
L
R
K
AE--RE--------
N
V
V
V
V
H
-------SCAVT
N
E
A
E
R
Q
V
K
Q
K
I
------
R
K
I
--Y--KNDPN
K
E
I
I
V
V
G
C
A
V
Q
-LDPESYS-NIP--------
G
V
S
K
V
LGNQDKLKTE
N
Y
L
L---SN
N
K
I
L
VNDN---------QASKSE
P
A
L
I
D
K
FKDK
S
R
A
F
I
E
V---QNGCDHS
C
T
--------
F
C
S
I
T-EARG-------N---NR-SV
P
I
N
N
I
-
I
E
Q
I
K
I
F
V
----A----------NGY
Q
E
V
V
F
TG-V--
D
-
I
T
DFGTDLFGK-P
S
L
G
L
M
V
R
R
V
L
K
D
-
V
-
P
--
E
L
----
K
R
L
RL-S-S----I
D
V
A
E
----------
V
D
D
E
L
M
D
L
-
I
--V----------NESRF--M
P
H
L
H
L
S
LQSG
N
N
----------
L
I
L
K
R
-
M
K
--
R
---R--H
S
R
E
Q
V
I
E
F
-
C
H
K
V
K
S
L
----
R
SNIA-Y--GA---D-IIA--G--FPT---
E
---
T
D
E
M
F
Q
D
T
V
N
L
L
EET
N
--
T
V
Y
L
HAFPYSKRKNTP-AARMP-Q-V
P
E
N
V
R
K
E
R
V
K
N
L
R
K
I
N
K
A
M
---
M
S
N
F
Y
Q
S
L
IGT
K
Q
S
V
L
V
EQN----N----I-------GRA-----E
N
F
-
A
-----
L
V
K
----
F
T-SKI
Q
A
K
S
I
V
K
A
T
I
I
GMESG
Y
-
L
V
GSIIP-------------------------
56
Fugue
91.90
25%
-80
- C4 -
4JC0
1
RIMO_THEMA
A:
[2-433]
-
R
V
-
G
I
K
V
L
G
C
P
K
N
E
A
D
C
E
V
L
A
-------
G
V
L
R
E
G
G
--
H
E
IVFDVKDA
D
V
V
V
L
D
-------
T
C
A
F
I
E
D
A
K
R
E
S
I
D
E
I
------
F
S
F
V
D
A
--
K
D
Q
Y
G
Y
K
L
V
V
K
G
C
L
V
Q
R
Y
Y
E
E
L
K
K
-
E
I
P
--------
E
V
D
Q
W
I
G
V
A
D
P
E
E
I
A
N
A
I
------------
E
T
---------
D
L
V
P
D
R
Y
R
K
R
I
D
L
E
E
R
P
Y
A
Y
V
K
I
---
S
D
G
C
D
R
G
C
T
--------
F
C
S
I
P
-
S
F
K
G
-------
S
---
L
R
-
S
R
S
I
E
D
I
-
T
R
E
V
E
D
L
L
----
K
----------
E
G
K
K
E
I
I
L
V
A
-
Q
--
D
-
T
T
S
Y
G
I
D
L
Y
R
K
-
Q
A
L
P
D
L
L
R
R
L
N
S
--
L
-
N
--
G
E
----
F
W
I
R
V
-
M
-
Y
----
L
H
P
D
H
----------
L
T
E
E
I
I
S
A
-
M
--
L
----------
E
L
D
K
V
--
V
K
Y
F
D
V
P
V
Q
H
G
S
D
----------
K
I
L
K
L
-
M
G
--
R
---
T
--
K
S
S
E
E
L
K
K
M
-
L
S
S
I
R
E
R
----
F
P
D
A
V
-
L
--
R
T
---
S
-
I
I
V
--
G
--
F
P
G
---
E
---
T
E
E
D
F
E
E
L
K
Q
F
V
E
E
I
Q
--
F
D
K
L
G
A
F
V
Y
S
D
E
E
G
T
V
-
A
F
N
L
K
E
K
-
V
D
P
E
M
A
K
R
R
Q
E
E
L
L
L
L
Q
A
E
I
---
S
N
S
R
L
D
R
F
V
G
K
K
L
K
F
L
V
E
G
K
----
E
GK
F
L
V
-------
G
R
T
WTEAP
E
V
D
-
G
-----
V
V
F
----
V
R
-
G
K
G
K
I
G
D
F
L
E
V
V
I
K
E
H
D
E
Y
D
-
M
W
G
S
V
I
L
EH-----------------------
1
PsiBlast_PDB
84.87
25%
-81
- C4 -
4JC0
1
RIMO_THEMA
A:
[7-379]
-------
V
L
G
C
P
K
N
E
A
D
C
E
V
L
A
-------
G
V
L
R
E
G
G
--
H
E
IVFDVKDA
D
V
V
V
L
D
-------
T
C
A
F
I
E
D
A
K
R
E
S
I
D
E
I
------
F
S
F
--
V
D
A
K
D
Q
Y
G
Y
K
L
V
V
K
G
C
L
V
Q
-
R
Y
Y
E
E
L
K
K
E
I
P
--------
E
V
D
Q
W
I
G
V
A
D
P
E
E
I
A
N
A
I
E
-----
T
D
L
V
P
D
---------------
R
Y
R
K
R
I
D
-
L
E
E
R
P
Y
A
Y
V
K
I
---
S
D
G
C
D
R
G
C
T
--------
F
C
S
I
P
-
S
F
K
G
-------
S
---
L
R
-
S
R
S
I
E
D
I
-
T
R
E
V
E
D
L
L
----
K
----------
E
G
K
K
E
I
I
L
V
A
-
Q
--
D
-
T
T
S
Y
G
I
D
L
Y
R
K
-
Q
A
L
P
D
L
L
R
R
-
L
N
S
-
L
-
N
--
G
E
----
F
W
I
R
V
-
M
-
Y
----
L
H
P
D
H
----------
L
T
E
E
I
I
S
A
-
M
--
L
----------
E
L
D
K
V
--
V
K
Y
F
D
V
P
V
Q
H
G
S
D
----------
K
I
L
K
L
-
M
G
--
R
---
T
--
K
S
S
E
E
L
K
K
M
-
L
S
S
I
R
E
R
----
F
P
D
A
V
-
L
--
R
T
---
S
-
I
I
V
--
G
--
F
P
G
---
E
---
T
E
E
D
F
E
E
L
K
Q
F
V
E
E
I
Q
--
F
D
K
L
G
A
F
V
Y
S
D
E
E
G
T
V
-
A
F
N
L
K
-
E
K
V
D
P
E
M
A
K
R
R
Q
E
E
L
L
L
L
Q
A
E
I
---
S
N
S
R
L
D
R
F
V
G
K
K
L
K
F
L
V
E
G
K
----
E
----
G
-------
K
F
L
-----
V
G
R
-
T
-----
W
T
E
----
A
P
-
E
V
D
G
V
V
F
V
R
G
K
G
K
I
G
D
F
L
E
V
-
V
I
K
E
H
D
E
-------------------------
32
HHSearch
74.77
26%
-84
- C4 -
2QGQ
1
RIMO_THEMA
A:
[3-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
Y
A
Y
V
K
I
---
S
D
G
C
----------------------
G
-------
S
---
L
R
-
S
R
S
I
E
D
I
-
T
R
E
V
E
D
L
L
----
K
----------
E
G
K
K
E
I
I
L
V
A
-
Q
--
D
-
T
T
S
Y
G
I
D
L
Y
R
K
-
Q
A
L
P
D
L
L
R
R
L
N
S
L
---
N
--
G
E
----
F
W
I
R
V
-
M
-
Y
----
L
H
P
D
H
----------
L
T
E
E
I
I
S
A
-
M
--
L
------------
E
L
D
KV
V
K
Y
F
D
V
P
V
Q
H
G
S
D
----------
K
I
L
K
L
-
M
G
--
R
---
T
--
K
S
S
E
E
L
K
K
M
-
L
S
S
I
R
E
R
----
F
P
D
A
V
-
L
--
R
T
---
S
-
I
I
V
--
G
--
F
P
G
---
E
---
T
E
E
D
F
E
E
L
K
Q
F
V
E
E
I
Q
--
F
D
K
L
G
A
F
V
Y
S
D
-------------K
V
D
P
E
M
A
K
R
R
Q
E
E
L
L
L
L
Q
A
E
I
---
S
N
S
R
L
D
R
F
V
G
K
K
L
K
F
L
V
E
G
K
EGK
F
L
----
V
-------
G
R
T
-----
W
T
E
-
A
-----
P
E
V
D
G
V
V
F
V
R
G
K
G
K
I
G
D
F
L
E
V
V
I
K
E
H
D
E
Y
D
-
M
W
G
S
V
I
--------------------------
2
PsiBlast_PDB
70.56
26%
-102
- C4 -
2QGQ
-
RIMO_THEMA
A:
[1-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
P
Y
A
Y
V
K
I
---
S
D
G
C
----------------------
G
-------
S
---
L
R
-
S
R
S
I
E
D
I
-
T
R
E
V
E
D
L
L
----
K
----------
E
G
K
K
E
I
I
L
V
A
-
Q
--
D
-
T
T
S
Y
G
I
D
L
Y
R
K
-
Q
A
L
P
D
L
L
R
R
L
N
S
L
-
N
-
G
--
E
F
-----
W
I
R
V
-
M
-
Y
----
L
H
P
D
H
----------
L
T
E
E
I
I
S
A
-
M
--
L
----------
E
L
D
K
V
--
V
K
Y
F
D
V
P
V
Q
H
G
S
D
----------
K
I
L
K
L
-
M
G
--
R
---
T
--
K
S
S
E
E
L
K
K
M
-
L
S
S
I
R
E
R
----
F
P
D
A
V
-
L
--
R
T
---
S
-
I
I
V
--
G
--
F
P
G
---
E
---
T
E
E
D
F
E
E
L
K
Q
F
V
E
E
I
Q
--
F
D
K
L
G
A
F
V
Y
S
D
-------------K
V
D
P
E
M
A
K
R
R
Q
E
E
L
L
L
L
Q
A
E
I
---
S
N
S
R
L
D
R
F
V
G
K
K
L
K
F
L
V
E
G
K
----
E
----
G
-------
K
F
L
-----
V
G
R
-
T
-----
W
T
E
----
A
P
-
E
V
D
G
V
V
F
V
R
G
K
G
K
I
G
D
F
L
E
V
-
V
I
K
E
H
D
E
-------------------------
57
Fugue
70.41
21%
-86
- C4 -
2QGQ
1
RIMO_THEMA
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
P
Y
A
--------
Y
V
K
I
S
-
D
G
C
G
-------
S
---
L
R
-
S
R
S
I
E
D
I
-
T
R
E
V
E
D
L
L
----
K
----------
E
G
K
K
E
I
I
L
V
A
-
Q
--
D
-
T
T
S
Y
G
I
D
L
Y
R
K
-
Q
A
L
P
D
L
L
R
R
L
N
S
--
L
-
N
--
G
E
----
F
W
I
R
V
M
Y
------
L
H
P
D
H
----------
L
T
E
E
I
I
S
A
M
L
-------------
E
L
D
K
V
--
V
K
Y
F
D
V
P
V
Q
H
G
S
D
----------
K
I
L
K
L
M
G
R
--
T
---
K
--
S
--
S
E
E
L
K
K
M
L
S
S
I
R
E
R
----
F
P
D
A
V
-
L
--
R
T
---
S
-
I
I
V
--
G
--
F
P
G
---
E
---
T
E
E
D
F
E
E
L
K
Q
F
V
E
E
I
Q
--
F
D
K
L
G
A
F
V
Y
S
D
K
V
D
P
E
M
A
-------------
K
R
R
Q
E
E
L
L
L
L
Q
A
E
I
---
S
N
S
R
L
D
R
F
V
G
K
K
L
K
F
L
V
E
G
K
----
E
GK
F
L
V
-------
G
R
T
-----
W
T
E
-
A
PEV
D
G
V
V
F
----
V
R
-
G
K
G
K
I
G
D
F
L
E
V
V
I
K
E
H
D
E
Y
D
M
W
G
S
V
I
---------------------------
16
PsiBlast_PDB
58.80
21%
-76
- C4 -
4JXC
6
HYDE_THEMA
A:
[54-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
I
I
E
F
---
S
N
V
C
R
K
N
C
L
--------
Y
C
G
L
R
-
R
D
N
K
-------
N
L
K
R
Y
R
-
M
T
P
-
E
E
I
-
V
E
R
A
R
L
A
V
----
Q
----------
F
G
A
K
T
I
V
L
Q
S
----------
G
E
D
P
Y
Y
M
-
P
D
-------
V
I
S
D
I
V
-
K
--
E
I
----
K
K
M
G
V
-
A
V
T
----
L
S
L
G
E
----------
W
P
R
E
Y
Y
E
K
-
W
K
E
A
----------
G
A
D
R
Y
--
L
----
L
R
H
E
T
A
N
P
----------
V
L
H
R
K
-
L
R
--
P
---
D
--
T
S
F
E
N
R
L
N
C
-
L
L
T
L
K
E
L
------
G
Y
E
-
T
--
G
A
---
G
-
S
M
V
--
G
--
L
P
G
---
Q
---
T
I
D
D
L
V
D
D
L
L
F
L
K
E
H
D
--
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
-
L
A
N
E
K
-
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
S
---
N
I
P
A
T
T
A
M
G
T
I
V
P
G
G
R
E
I
T
L
----
R
----
C
-------
G
A
N
-----
V
I
M
-
P
-----
N
W
T
----
P
S
-
P
Y
R
Q
L
Y
Q
L
Y
P
G
K
I
C
V
F
E
K
D
T
-
A
C
I
P
C
V
M
-------------------------
18
PsiBlast_PDB
58.78
21%
-74
- C4 -
4JY9
7
HYDE_THEMA
A:
[54-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
I
I
E
F
---
S
N
V
C
R
K
N
C
L
--------
Y
C
G
L
R
-
R
D
N
K
-------
N
L
K
R
Y
R
-
M
T
P
-
E
E
I
-
V
E
R
A
R
L
A
V
----
Q
----------
F
G
A
K
T
I
V
L
Q
S
----------
G
E
D
P
Y
Y
M
-
P
D
-------
V
I
S
D
I
V
-
K
--
E
I
----
K
K
M
G
V
-
A
V
T
----
L
S
L
G
E
----------
W
P
R
E
Y
Y
E
K
-
W
K
E
A
----------
G
A
D
R
Y
--
L
----
L
R
H
E
T
A
N
P
----------
V
L
H
R
K
-
L
R
--
P
---
D
--
T
S
F
E
N
R
L
N
C
-
L
L
T
L
K
E
L
------
G
Y
E
-
T
--
G
A
---
G
-
S
M
V
--
G
--
L
P
G
---
Q
---
T
I
D
D
L
V
D
D
L
L
F
L
K
E
H
D
--
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
-
L
A
N
E
K
-
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
S
---
N
I
P
A
T
T
A
M
G
T
I
V
P
G
G
R
E
I
T
L
----
R
----
C
-------
G
A
N
-----
V
I
M
-
P
-----
N
W
T
----
P
S
-
P
Y
R
Q
L
Y
Q
L
Y
P
G
K
I
C
V
F
E
K
D
T
-
A
C
I
P
C
V
M
-------------------------
15
PsiBlast_PDB
58.68
21%
-76
- C4 -
3CIX
5
HYDE_THEMA
A:
[54-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
I
I
E
F
---
S
N
V
C
R
K
N
C
L
--------
Y
C
G
L
R
-
R
D
N
K
-------
N
L
K
R
Y
R
-
M
T
P
-
E
E
I
-
V
E
R
A
R
L
A
V
----
Q
----------
F
G
A
K
T
I
V
L
Q
S
----------
G
E
D
P
Y
Y
M
-
P
D
-------
V
I
S
D
I
V
-
K
--
E
I
----
K
K
M
G
V
-
A
V
T
----
L
S
L
G
E
----------
W
P
R
E
Y
Y
E
K
-
W
K
E
A
----------
G
A
D
R
Y
--
L
----
L
R
H
E
T
A
N
P
----------
V
L
H
R
K
-
L
R
--
P
---
D
--
T
S
F
E
N
R
L
N
C
-
L
L
T
L
K
E
L
------
G
Y
E
-
T
--
G
A
---
G
-
S
M
V
--
G
--
L
P
G
---
Q
---
T
I
D
D
L
V
D
D
L
L
F
L
K
E
H
D
--
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
-
L
A
N
E
K
-
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
S
---
N
I
P
A
T
T
A
M
G
T
I
V
P
G
G
R
E
I
T
L
----
R
----
C
-------
G
A
N
-----
V
I
M
-
P
-----
N
W
T
----
P
S
-
P
Y
R
Q
L
Y
Q
L
Y
P
G
K
I
C
V
F
E
K
D
T
-
A
C
I
P
C
V
M
-------------------------
17
PsiBlast_PDB
57.70
21%
-74
- C4 -
4JY8
6
HYDE_THEMA
A:
[64-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
I
I
E
F
---
S
N
V
C
R
K
N
C
L
--------
Y
C
G
L
R
-
R
D
N
K
-------
N
L
K
R
Y
R
-
M
T
P
-
E
E
I
-
V
E
R
A
R
L
A
V
----
Q
----------
F
G
A
K
T
I
V
L
Q
S
----------
G
E
D
P
Y
Y
M
-
P
D
-------
V
I
S
D
I
V
-
K
--
E
I
----
K
K
M
G
V
-
A
V
T
----
L
S
L
G
E
----------
W
P
R
E
Y
Y
E
K
-
W
K
E
A
----------
G
A
D
R
Y
--
L
----
L
R
H
E
T
A
N
P
----------
V
L
H
R
K
-
L
R
--
P
---
D
--
T
S
F
E
N
R
L
N
C
-
L
L
T
L
K
E
L
------
G
Y
E
-
T
--
G
A
---
G
-
S
M
V
--
G
--
L
P
G
---
Q
---
T
I
D
D
L
V
D
D
L
L
F
L
K
E
H
D
--
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
-
L
A
N
E
K
-
K
-
G
D
F
T
L
T
L
K
M
V
A
L
T
R
I
L
L
P
D
S
---
N
I
P
A
T
T
A
M
G
T
I
V
P
G
G
R
E
I
T
L
----
R
----
C
-------
G
A
N
-----
V
I
M
-
P
-----
N
W
T
----
P
S
-
P
Y
R
Q
L
Y
Q
L
Y
P
G
K
I
C
V
F
E
K
D
T
-
A
C
I
P
C
V
M
-------------------------
58
Fugue
54.24
13%
-35
- C4 -
3T7V
3
PYLB_METBF
A:
[12-348]
------------------
S
L
G
D
-------
K
V
I
E
G
Y
Q
L
T
D
N
--------
D
L
R
T
L
L
-------
S
-
L
E
S
K
E
G
L
E
R
L
Y
S
A
A
------
R
K
V
--
R
--
D
H
Y
F
G
N
------------------------------------------------------------------------------------
R
V
F
L
N
C
F
I
Y
F
---
S
T
Y
C
K
N
Q
C
S
--------
F
C
Y
Y
N
-
C
R
N
E
-------
I
---
N
R
Y
R
L
T
M
E
E
I
-
K
E
T
C
K
T
L
K
----
G
----------
A
G
F
H
M
V
D
L
T
M
-
G
--
E
-
D
P
Y
Y
Y
E
D
---
P
-
N
R
F
V
E
L
V
Q
I
V
K
E
E
-
L
-
G
-----------
L
P
-
I
-
M
----
I
S
P
G
L
----------
M
D
N
A
T
L
L
K
-
A
--
R
----------
E
K
G
----
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
----------
E
L
Y
R
K
-
L
R
--
V
---
G
--
Q
S
F
D
G
R
V
N
A
-
R
R
F
A
K
Q
Q
------
G
Y
C
-
V
--
E
D
---
G
-
I
L
T
--
G
--
V
G
----
N
---
D
I
E
S
T
I
L
S
L
R
G
M
S
T
N
D
--
P
D
M
V
R
V
M
T
F
L
P
Q
E
G
T
P
-
L
E
G
F
R
-
D
-
K
S
N
L
S
E
L
K
I
I
S
V
L
R
L
M
F
P
K
R
L
I
P
A
S
L
D
L
E
G
I
D
G
M
V
L
R
L
N
A
G
A
N
----
I
----
V
TSILPPD
S
Q
L
-----
E
G
V
-
A
-----
N
Y
D
----
R
D
-
L
E
E
R
D
R
D
I
K
S
V
V
R
R
L
E
I
M
G
M
-
K
P
A
R
Q
A
D
F
E
A
V
L--------------------
41
HHSearch
53.07
18%
-71
- C4 -
3RFA
2
RLMN_ECOLI
A:
[113-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
A
T
L
C
V
S
S
---
Q
V
G
C
A
L
E
C
K
--------
F
C
S
T
A
-
Q
Q
G
--------
F
---
N
R
-
N
L
R
V
S
E
I
-
I
G
Q
V
W
R
A
A
----
K
I
V
GAAKVTGQ
R
P
I
T
N
V
V
M
M
G
M
G
--
E
-
P
L
L
N
L
N
N
-------
V
V
P
A
M
E
I
M
L
D
D
---
F
--
G
F
GLSK
R
R
V
T
L
-
S
------
T
S
G
V
V
----------
P
A
L
D
K
L
G
D
-
M
-----------------
I
--
D
V
A
L
A
I
S
L
H
A
P
N
D
----------
E
I
R
D
E
-
I
V
--
P
INK
K
--
Y
N
I
E
T
F
L
A
A
-
V
R
R
Y
L
E
K
SNAN
Q
G
R
V
T
-
I
--
E
Y
---
V
-
M
L
D
--
H
---
V
N
---
D
---
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
-
I
N
L
I
P
W
N
P
F
P
G
A
P
-
Y
G
R
S
S
-
N
-
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
---
K
T
R
G
D
-----------------------------------------------------------------------------------------------------------------
34
HHSearch
52.78
16%
-95
- C4 -
1OLT
3
HEMN_ECOLI
A:
[51-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
L
S
L
Y
V
H
I
---
P
-
F
C
H
K
L
C
Y
--------
F
C
G
C
N
-
K
I
V
T
-------
R
QQH
K
A
-
D
Q
Y
L
D
A
L
-
E
Q
E
I
V
H
R
A
PLFA
G
----------
R
H
V
S
Q
L
H
W
G
G
-
G
--
T
-
P
T
Y
L
N
K
A
------
Q
I
S
R
L
M
K
L
L
R
E
N
-
F
-
Q
FN
A
D
----
A
E
I
S
I
---
E
----
V
D
P
R
E
----------
I
E
L
D
V
L
D
H
-
L
--
R
------------
A
E
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
----------
E
V
Q
R
L
-
V
N
--
R
---
E
--
Q
D
E
E
F
I
F
A
L
-
L
N
H
A
R
E
I
----
G
--
F
T
S
T
--
N
I
---
D
-
L
I
Y
--
G
--
L
P
K
---
Q
---
T
P
E
S
F
A
F
T
L
K
R
V
A
E
L
N
--
P
D
R
L
S
V
F
N
Y
A
H
L
P
T
I
F
-
A
A
Q
R
K
-
I
-
K
D
A
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
---
F
L
T
Q
S
G
Y
Q
F
I
G
M
D
H
F
A
R
P
D
D
----
E
----
L
-------
A
V
A
-----
Q
R
E
-
G
-----
V
L
H
----
R
N
-
F
Q
G
Y
T
T
Q
G
D
T
D
L
L
G
M
G
V
S
A
I
-
S
M
I
G
D
C
Y
-------------------------
39
HHSearch
52.10
15%
-97
- C4 -
2A5H
5
KAMA_CLOSU
A:
[112-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
P
D
R
V
L
L
L
I
---
T
D
M
C
S
M
Y
C
R
--------
H
C
T
R
R
-
R
F
A
G
Q------
S
---
D
D
-
S
M
P
M
E
R
I
-
D
K
A
I
D
Y
I
R
----
N
T
---------
P
Q
V
R
D
V
L
L
S
G
-
G
--
D
-
A
L
L
V
S
D
E
------
T
L
E
Y
I
I
A
K
L
R
E
I
---
P
--
H
V
----
E
I
V
R
I
-
G
-
S
RTPV
V
L
P
Q
R
----------
I
T
P
E
L
V
N
M
-
L
--
K
------------
K
Y
H
--
P
V
W
L
N
T
H
F
N
H
P
N
E
----------
I
------------------
T
E
E
S
T
R
A
-
C
Q
L
L
A
D
A
----
G
--
V
P
-
L
--
G
N
---
Q
S
V
L
L
--
R
--
G
V
N
---
D
---
C
V
H
V
M
K
E
L
V
N
K
L
V
K
I
R
--
V
R
P
Y
Y
I
Y
Q
C
D
L
S
L
G
L
E
-
H
F
R
T
P
-
V
-
S
K
G
I
E
I
I
E
G
L
R
G
H
T
S
G
Y
C
V
P
---
T
F
V
V
D
A
P
G
G
G
G
K
T
P
V
M
P
N
Y
V
----
I
----
S
-------
Q
S
H
-----
D
K
V
-
I
-----
L
R
N
----
F
E
-
G
V
I
T
T
Y
S
E
P
I
N
Y
T
P
G
C
N
C
D
V
-
C
T
G
K
K
K
V
-------------------------
35
HHSearch
51.71
14%
-78
* C4 *
3T7V
3
PYLB_METBF
A:
[61-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
C
F
I
Y
F
---
S
T
Y
C
K
N
Q
C
S
--------
F
C
Y
Y
N
-
C
R
N
E
I
------
N
---
R
Y
-
R
L
T
M
E
E
I
-
K
E
T
C
K
T
L
K
----
G
----------
A
G
F
H
M
V
D
L
T
M
-
G
--
E
D
P
Y
Y
Y
E
D
----
P
-
N
R
F
V
E
L
V
Q
I
V
K
E
E
------------
L
G
L
P
I
-
M
------
I
S
P
G
L
----------
M
D
N
A
T
L
L
K
-
A
--
R
------------
E
K
G
--
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
----------
E
L
Y
R
K
-
L
R
--
V
---
G
--
Q
S
F
D
G
R
V
N
A
-
R
R
F
A
K
Q
Q
----
G
--
Y
C
-
V
--
E
D
---
G
-
I
L
T
--
G
--
V
G
N
-------
D
I
E
S
T
I
L
S
L
R
G
M
S
T
N
D
--
P
D
M
V
R
V
M
T
F
L
P
Q
E
G
T
P
-
L
E
G
F
R
-
D
-
K
S
N
L
S
E
L
K
I
I
S
V
L
R
L
M
F
P
K
R
---
L
I
P
A
S
L
D
L
E
G
I
D
G
M
V
L
R
L
N
A
----
G
----
A
-------
N
I
V
-----
T
S
I
-
L
-----
P
P
D
----
S
Q
-
L
E
G
V
A
N
Y
D
R
D
L
E
E
R
D
R
D
I
K
S
-
V
V
R
R
L
E
I
-------------------------
36
HHSearch
50.23
15%
-76
- C4 -
1R30
4
BIOB_ECOLI
A:
[72-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
T
G
A
C
P
E
D
C
K
--------
Y
C
P
Q
S
-
S
R
Y
K
TGLE---
A
---
E
R
-
L
M
E
V
E
Q
V
-
L
E
S
A
R
K
A
K
----
A
----------
A
G
S
T
R
F
C
M
G
A
-
A
WK
N
-
P
H
E
R
D
M
------
P
Y
L
E
Q
M
V
Q
G
V
K
A
M
-------------
G
L
E
A
-
C
-
M
-----
T
L
G
T
----------
L
S
E
S
Q
A
Q
R
-
L
--
A
------------
N
A
G
--
L
D
Y
Y
N
H
N
L
D
T
-
S
P
----------
E
F
Y
G
N
-
I
I
--
T
---
T
--
R
T
Y
Q
E
R
L
D
T
-
L
E
K
V
R
D
A
----
G
--
I
K
-
V
--
C
S
---
G
-
G
I
V
--
G
--
L
-
G
---
E
---
T
V
K
D
R
A
G
L
L
L
Q
L
A
N
L
P
TP
P
E
S
V
P
I
N
M
L
V
K
V
K
G
T
P
-
L
A
D
N
D
-
D
-
V
D
A
F
D
F
I
R
T
I
A
V
A
R
I
M
M
P
T
S
---
Y
V
R
L
S
A
G
R
E
Q
M
N
E
Q
T
Q
A
M
C
F
----
M
----
A
-------
G
A
N
-----
S
I
F
-
Y
-----
G
C
K
----
L
L
-
T
T
P
N
P
E
E
D
K
D
L
Q
L
F
R
K
L
G
L
N
-
P
Q
Q
T
----------------------------
37
HHSearch
48.96
10%
-115
- C4 -
1TV8
4
MOAA_STAA8
A:
[12-200]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
R
D
L
R
L
S
V
---
T
D
R
C
N
F
R
C
D
--------
Y
C
M
P
K
-
E
V
F
G
DDFVFLP
K
---
N
E
-
L
L
T
F
D
E
M
-
A
R
I
A
K
V
Y
A
----
E
----------
L
G
V
K
K
I
R
I
T
G
-
G
--
E
-
P
L
M
R
R
D
--------
L
D
V
L
I
A
K
L
N
Q
I
---
D
--
G
I
----
E
D
I
G
L
---
T
----
T
N
G
L
L
----------
L
K
K
H
-
G
Q
K
-
L
--
Y
------------
D
A
G
--
L
R
R
I
N
V
S
L
D
A
I
D
D
----------
T
L
F
Q
S
-
I
N
--
N
R--
N
--
I
K
A
T
T
I
L
E
Q
-
I
D
Y
A
T
S
I
----
G
--
L
N
-
V
--
K
V
---
N
-
V
V
I
--
Q
---
K
G
---
I
---
N
D
D
Q
I
I
P
M
L
E
Y
F
K
D
K
H
--
I
E
-
I
R
F
I
E
F
M
D
V
G
N
D
N
-
G
W
D
F
S
-
K
-
V
V
T
K
D
E
M
L
T
M
I
E
Q
H
F
E
I
D
P
V
---
E
P
K
Y
F
G
E
V
A
K
Y
Y
R
H
K
D
N
G
V
Q
----
F
----
G
-------
L
I
T
-----
S
V
S
-
Q
-----
S
F
C
----
S
T
-
C
T
R
A
R
L
S
S
D
G
K
F
Y
G
C
L
F
A
T
V
-
D
G
F
N
V
K
A
-------------------------
59
Fugue
47.78
18%
-31
* C3 *
3VWA
-
CEX1_YEAST
A:
[1-540]
P
L
H
M
S
I
S
N
F
Q
F
P
Y
T
I
E
E
T
A
I
T
E
TAL
W
Q
C
F
D
G
T
R
K
A
D
--
S
L
--------
P
V
T
V
F
K
A
KRSPEN
E
S
L
I
L
N
A
V
H
K
S
K
I
L
K
I
PGLCTV
L
E
T
--
F
--
D
S
D
P
Q
S
T
F
I
V
T
E
R
V
V
P
-
F
P
W
D
N
L
G
-
S
L
S
Q
N
K
F
G
V
E
L
G
I
S
Q
L
L
A
T
L
G
F
L
K
--
N
F
V
L
GTL
S
K
D
S
V
F
I
N
I
K
G
E
W
V
L
F
G
LE
L
C
S
S
K
E
G
L
S
A
F
E
F
A
S
R
A
R
S
Y
Y
N
I
I
GS
Q
L
P
C
E
D
P
N
T
I
D
S
M
G
L
G
L
L
I
K
S
L
M
A
P
S
C
-------
L
---
P
K
-
D
W
I
V
N
V
N
M
I
S
D
G
K
I
T
I
----
E
----------
N
F
R
K
R
L
E
N
T
E
-
T
--
W
-
R
S
N
P
L
I
N
F
Y
Q
E
L
R
E
L
H
I
K
D
P
Q
G
K
L
V
-
V
M
S
--
N
L
----
E
N
L
Y
L
-
E
-
S
----
R
E
I
F
R
NLTPGMIENF
I
I
P
E
L
C
E
I
-
I
--
K
L
L
M
T
Q
S
I
SSN
A
S
H
K
L
--
V
P
F
L
A
I
V
L
D
L
T
S
E
T
NTFPVG
F
N
D
L
I
T
Q
S
-
F
K
LP
D
---
R
--
Q
V
R
F
L
L
L
I
Y
-
L
P
K
L
I
G
P
LS--
K
S
E
I
S
-
S
RI
Y
P
---
H
-
F
I
Q
--
G
--
L
T
D
---
S
---
D
A
T
L
R
L
Q
T
L
K
T
I
P
C
I
V
--
S
C
L
T
E
R
Q
L
N
N
E
L
L
R
F
L
-
A
K
T
Q
V
-
D
-
S
D
V
E
I
R
T
W
T
V
I
I
I
S
K
I
S
T
I
L
STS
V
G
N
R
S
N
I
L
A
T
A
F
T
K
S
L
K
D
P
Q
----
V
----
K
-------
P
R
L
-----
A
A
L
Y
G
-----
L
E
K
----
S
I
-
E
L
F
D
V
N
T
I
A
N
K
I
L
T
V
I
A
P
G
L
-
L
D
K
S
P
I
V
R
G
R
A
K
I
L
F
E
E
Y
L
E
K
L
E
K
E
A
Q
L
IQTN
51
HHSearch
42.97
7%
-104
- C4 -
2FTP
2
LIUE_PSEAE
A:
[26-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
E
V
A
D
K
-
I
R
L
V
D
D
L
S
----
A
----------
A
G
L
D
Y
I
E
V
G
S
-
F
--
V
-
S
P
K
W
V
P
Q
M
----
A
G
S
A
E
V
F
A
G
I
R
Q
R
---
P
---------
G
V
T
Y
-
A
-
A
-----
L
A
P
------------
N
L
K
G
F
E
A
-
A
--
L
------------
E
S
G
--
V
K
E
V
A
V
F
A
A
A
S
E
A
----------
F
S
Q
R
N
-
I
N
--
C
S
I
-
K
--
D
S
L
E
R
F
V
P
V
-
L
E
A
A
R
Q
H
----
Q
--
V
R
-
V
--
R
G
---
Y
-
I
S
C
VL
G
--
C
P
Y
DGD
V
---
D
P
R
Q
V
A
W
V
A
R
E
L
Q
Q
M
G
--
C
Y
E
V
S
L
G
D
T
I
G
V
G
T
A
G
-
A
T
R
R
L
-
I
-
E
A
V
A
S
E
V
P
R
E
R
L
A
G
H
F
H
D
T
Y
---
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
S
----
S
----
V
-------
A
G
L
-----
G
G
C
-
P
-----
Y
A
K
----
G
A
-
T
G
N
V
A
S
E
D
V
L
Y
L
L
N
G
L
E
I
H
T
-
G
V
D
M
H
A
L
-------------------------
11
PsiBlast_PDB
41.99
26%
-56
- C4 -
1OLT
2
HEMN_ECOLI
A:
[146-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
R
E
----------
I
E
L
D
V
L
D
H
-
L
--
R
----------
A
E
G
----
F
N
R
L
S
M
G
V
Q
D
F
N
--------------
K
E
-
V
Q
--
R
---
L
--
V
N
R
E
Q
D
E
E
F
-
I
F
A
L
L
N
H
----
A
R
E
I
G
-
F
--
T
S
T
N
I
D
-
L
I
Y
--
G
--
L
P
K
---
Q
---
T
P
E
S
F
A
F
T
L
K
R
V
A
E
L
N
--
P
D
R
L
S
V
F
N
Y
A
H
L
P
T
I
F
-
A
A
Q
R
K
-
I
-
K
D
A
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
---
F
L
T
Q
S
G
Y
Q
F
I
G
M
D
H
F
A
R
P
D
D
----
E
----
L
-------
A
V
A
-----
Q
R
E
-
G
-----
V
L
H
----
R
N
-
F
Q
G
Y
T
T
Q
G
D
T
D
L
L
G
M
G
V
S
A
I
-
S
M
I
G
D
C
Y
-------------------------
48
HHSearch
41.96
11%
-82
- C4 -
1YDO
1
HMGCL_BACSU
A:
[24-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
A
T
E
D
K
-
I
T
W
I
N
Q
L
S
----
R
----------
T
G
L
S
Y
I
E
I
T
S
-
F
------
V
H
P
K
W
I
----
P
A
L
R
D
A
I
D
V
A
K
G
--
I
-
D
--
R
E
----
K
G
V
T
Y
-
A
-
A
----
L
V
P
-------------
N
Q
R
G
L
E
N
-
A
--
L
------------
E
G
G
--
I
N
E
A
C
V
F
M
S
A
S
E
T
----------
H
N
R
K
N
-
I
N
--
K
---
S
T
S
E
S
L
H
I
L
K
Q
V
-
N
N
D
A
Q
K
A
----
N
--
L
T
-
T
--
R
A
---
Y
-
L
S
T
--
V
FG
C
P
Y
---
E
KDV
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
F
G
--
I
S
E
L
S
L
G
D
T
I
G
A
A
N
P
A
-
Q
V
E
T
V
-
L
-
E
A
L
L
A
R
F
P
A
N
Q
I
A
L
H
F
H
D
T
R
---
G
T
A
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
G
----
S
----
A
-------
G
G
L
-----
G
G
C
-
P
-----
Y
A
P
----
G
S
-
S
G
N
A
A
T
E
D
I
V
Y
M
L
E
Q
M
D
I
K
T
-
N
V
K
L
E
K
L
-------------------------