@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0298: (2015-11-30 )
MKIRVGINGLGRIGRSVLRAIHEVGKYNEQIEVVAVNGSLSTEQHAHLIRYDSVHGKFNGDIGFNESENWISTNGKKFSLYRERNPENIPWDVDVVLECTGAFNKRAEAAKHNTGKVIVSAPVSDADITIVYGVNNDMLKKEHKVISAGSCTTNCLAPVVKVLHFNLDMKSGFMTTVHAYTNDQNVLDGNHRDLRRARACGLSIVPTTTGAAKTIGSVIPELKGKLDGTAIRVPVANVSMVDLKFTTDKKVTAKEINEIFKNSVNDVLSICKEPLVSIDFVHNPYSAIVDLAGTYVTGDICRVAAWYDNEWAFSLRMLDIALLCYNRI
Atome Classification :
(41 SA)
.........10........20........30........-40........50........60.......-.70........80.-.......90---.---.---......100.......110---..-.---.--...120..-....-.130.......-140.-.-......150.......160...-....170.......180.......190-......-..200.......210.......220.......230.......240.......250..-......260--..----.-----------.-----------.----.----...270.....-..280.......290....-.-.-.300.......310.......320......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
R
V
GI
N
G
L
G
R
I
G
R
S
V
L
R
A
I
H
E
VGKYN
E
Q
I
E
V
V
A
VNGS-LS
T
E
Q
H
A
H
L
I
R
YDSVH
G
K
FNGDIGFNESE-NWISTNG
K
K
F
S
L
Y
R-ERNPENIPW---D---
V
---
D
V
V
L
E
CTGAFNK
R
A
E
AAKH---NT-
G
---
K
--
V
I
V
SAPVS-DA
D
I
-
T
I
V
Y
GVN
N
D
M
L
-
K
K
-
E
-
H
-
K
V
ISAGSC
T
T
N
C
L
A
P
V
V
K
V
L
HF-NLDMKSG
F
M
T
T
V
H
A
YTNDQNVLDG
N
H
--
R
D
L
R
R
A
-
R
ACG
L
S
I
V
PTTTG
A
A
K
T
I
G
S
V
I
P
E
L
KGKLDG
T
A
I
R
V
PVA
N
V
S
M
V
D
L
K
FTTDKK-
V
T
A
-
K
E
I
N
E
I
F
----
K
N
----
S
-----------
V
-----------
N
----
D
----
V
L
S
I
C
KEP
L
V
S
-
I
D
FVH
N
P
Y
S
A
I
V
D
LA
G
T
YV-T-G-D
I
C
R
V
A
A
W
YDN
E
W
A
F
S
L
R
M
L
D
I
A
L
L
C
YNRI-
1
PsiBlast_PDB
96.23
52%
-116
- C3 -
3L0D
1
?
A:
[22-350]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
G
R
--
Q
D
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
V
--
Q
V
V
G
-
D
A
I
D
I
---
L
I
K
V
F
A
-
E
R
D
P
A
Q
L
P
W
KAL
D
---
I
---
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
-
K
---
R
--
V
L
V
S
A
P
S
E
-
G
A
D
L
-
T
V
V
Y
G
V
N
H
Q
F
L
-
S
K
-
E
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
-
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
-
E
E
I
N
T
A
I
----
R
T
A
A
Q
G
S
-----------
L
-----------
K
----
G
----
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
-
I
D
G
-
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
-
21
PsiBlast_CBE
95.23
52%
-117
- C3 -
3L0D
1
?
B:
[22-350]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
G
R
--
Q
D
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
V
--
Q
V
V
G
-
D
A
I
D
I
---
L
I
K
V
F
A
-
E
R
D
P
A
Q
L
P
W
KAL
D
---
I
---
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
LDA
G
A
-
K
---
R
--
V
L
V
S
A
P
S
E
-
G
A
D
L
-
T
V
V
Y
G
V
N
H
Q
F
L
-
S
K
-
E
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
-
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
-
E
E
I
N
T
A
I
----
R
T
AAQG
S
-----------
L
-----------
K
----
G
----
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
-
I
D
G
-
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
-
97
PsiBlast_CBE
94.33
47%
-123
- C3 -
2DUU
1
?
Q:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
------------------
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
QKAS
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
127
HHSearch
93.88
50%
-119
* C3 *
3CMC
14
G3P_GEOSE
O:
[1-333]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
N
----
P
D
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
-
N
-
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
---
L
E
A
G
AK-
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
-
D
P
K
A
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
-----------
A
-----------
E
GELK
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
-
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
98
PsiBlast_CBE
93.88
47%
-120
- C3 -
2DUU
1
?
P:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
------------------
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
QKAS
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
27
PsiBlast_CBE
93.26
50%
-116
- C3 -
3GNQ
2
?
C:
[10-342]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
N
G
K
K
H
D
-
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
G
E
V
S
V
D
G
---
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
-
N
R
N
P
A
E
L
P
W
---
G
ELG
V
---
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
---
L
K
-
G
GAK
K
--
V
I
I
S
A
P
G
G
K
D
V
D
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
A
-
E
-
H
-
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
-
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
-
A
E
V
N
A
I
M
----
K
E
ASEG
A
-----------
L
-----------
K
----
G
----
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
-
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
118
HHSearch
93.04
51%
-119
- C3 -
3DOC
2
?
A:
[1-335]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
S
--
G
R
T
D
I
Q
V
V
A
I
N
D
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
K
E
V
E
V
-
A
-
G
-
D
T
I
D
V
G
Y
G
P
I
K
V
H
A
-
V
R
N
P
A
E
L
P
W
---
K
EEN
V
---
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
---
L
E
A
G
AK-
R
--
V
I
V
S
A
P
A
D
-
G
A
D
L
-
T
V
V
Y
G
V
N
N
D
K
L
-
T
K
-
D
-
H
-
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
-
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
--
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
E
-
T
T
V
-
E
E
V
N
N
A
I
----
R
E
----
A
-----------
A
N
GRL-------
K
----
G
----
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
-
M
-
D
G
T
M
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
L
I
-
101
PsiBlast_CBE
92.76
47%
-123
- C3 -
2DUU
1
?
A:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
------------------
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
Q
K
A
S
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
22
PsiBlast_CBE
92.72
50%
-116
- C3 -
3GNQ
2
?
H:
[10-342]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
N
G
K
K
H
D
-
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
G
E
V
S
V
D
G
---
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
-
N
R
N
P
A
E
L
P
W
---
G
ELG
V
---
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
---
L
K
-
G
GAK
K
--
V
I
I
S
A
P
G
G
K
D
V
D
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
A
-
E
-
H
-
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
-
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
-
A
E
V
N
A
I
M
----
K
E
ASEG
A
-----------
L
-----------
K
----
G
----
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
-
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
42
PsiBlast_CBE
92.68
49%
-117
- C3 -
3DBV
3
G3P_GEOSE
R:
[2-326]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
D
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
---
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
LEA
G
A
-
K
---
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
AEGE-------
L
-----------
K
----
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
D
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
100
PsiBlast_CBE
92.66
47%
-121
- C3 -
2DUU
1
?
B:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
------------------
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
QKAS
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
5
PsiBlast_PDB
92.64
50%
-115
- C3 -
1DBV
3
G3P_GEOSE
O:
[2-326]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
D
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
---
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
LEA
G
A
-
K
---
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
AEGE-------
L
-----------
K
----
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
D
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
117
HHSearch
92.57
48%
-116
- C3 -
1RM4
3
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
R
K
--
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
T
-
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
---
L
Q
A
G
AK-
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
NELK
G
----
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
99
PsiBlast_CBE
92.47
47%
-120
- C3 -
2DUU
1
?
O:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
------------------
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
QKAS
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
104
PsiBlast_CBE
92.37
47%
-117
- C3 -
2D2I
2
?
P:
[1-336]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
--
G
R
Q
N
T
D
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
I
S
Y
D
E
---
N
S
I
T
V
N
G
K
T
M
K
I
V
C
-
D
R
N
P
L
N
L
P
W
KEW
D
---
I
---
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
IQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
-
R
H
-
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
-
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
-
E
Q
V
N
E
V
L
QKAS
Q
T
----
T
-----------
M
-----------
K
----
G
----
I
I
K
Y
S
D
L
P
L
V
S
-
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
-
M
D
G
-
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
-
6
PsiBlast_PDB
92.31
50%
-117
- C3 -
2DBV
4
G3P_GEOSE
O:
[2-326]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
D
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
---
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
LEA
G
A
-
K
---
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
AEGE-------
L
-----------
K
----
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
D
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
106
Fugue
92.09
49%
-121
- C3 -
1GD1
4
G3P_GEOSE
O:
[1-334]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
N
P
D
----
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
---G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E-
R
D
P
E
N
L
A
W
---
G
---
E
IGV
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
---
L
E
-
A
GAK
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
-
D
P
-
K
-
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q-
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
-
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
-----------
A
EGEL-------
K
----
G
----
I
L
A
Y
S
E
E
-
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
-
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
L
2
PsiBlast_PDB
92.09
50%
-116
- C3 -
3GNQ
1
?
A:
[10-342]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
A
F
Y
E
N
G
K
K
H
D
-
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
P
G
E
V
S
V
D
G
---
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
-
N
R
N
P
A
E
L
P
W
---
G
ELG
V
---
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
---
L
K
-
G
GAK
K
--
V
I
I
S
A
P
G
G
K
D
V
D
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
A
-
E
-
H
-
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
-
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
-
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
-
A
E
V
N
A
I
M
----
K
E
A
S
E
G
A
-----------
L
-----------
K
----
G
----
I
L
G
Y
N
E
A
P
L
V
S
-
I
D
F
N
H
N
P
A
S
S
T
F
D
A
T
L
T
K
V
-
S
-
G
-
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
K
-
50
PsiBlast_CBE
92.07
49%
-114
- C3 -
2GD1
2
G3P_GEOSE
P:
[2-326]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
D
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
---
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
LEA
G
A
-
K
---
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
-
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
AEGE-------
L
-----------
K
----
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
D
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
57
PsiBlast_CBE
92.03
49%
-115
- C3 -
1NPT
3
G3P_GEOSE
R:
[2-326]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
D
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
---
N
N
L
V
V
N
G
K
E
I
I
V
K
A
-
E
R
D
P
E
N
L
A
W
---
G
EIG
V
---
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
LEA
G
A
-
K
---
K
--
V
I
I
S
A
P
A
K
-
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
-
H
-
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
-
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
-
E
E
V
N
A
A
L
----
K
A
----
A
AEGE-------
L
-----------
K
----
G
----
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
-
I
D
G
-
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
-
121
HHSearch
91.74
49%
-113
- C3 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
--
N
P
D
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
-
T
-
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
-
E
P
D
P
S
K
L
P
W
---
K
DLG
V
---
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
---
L
Q
A
G
AK-
K
--
V
I
I
T
A
P
A
K
-
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
-
E
-
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
-
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
----
K
E
----
A
-----------
T
EGRL-------
K
----
G
----
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
-
I
-
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
92
PsiBlast_CBE
90.10
45%
-112
- C3 -
1RM3
6
G3PA_SPIOL
A:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
19
PsiBlast_PDB
90.06
45%
-113
- C3 -
1RM4
3
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
75
PsiBlast_CBE
89.88
45%
-111
- C3 -
1RM4
6
G3PA_SPIOL
A:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
76
PsiBlast_CBE
89.77
45%
-113
- C3 -
1NBO
4
G3PA_SPIOL
B:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
124
HHSearch
89.75
51%
-115
- C3 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
----
E
E
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
-
K
-
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
-
Q
K
D
P
S
Q
I
P
W
---
G
DLG
V
---
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
---
L
Q
G
G
---
A
K
K
V
I
I
T
A
P
A
K
-
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
-
N
P
K
E
-
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
-
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
S
S
V
-
E
E
V
N
E
K
F
----
R
E
----
A
-----------
A
Q
K
Y
R
E
SGKVYL
K
----
E
----
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
-
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
90
PsiBlast_CBE
89.04
45%
-113
- C3 -
1RM3
5
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
18
PsiBlast_PDB
88.95
45%
-111
- C3 -
1NBO
3
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
93
PsiBlast_CBE
88.91
45%
-114
- C3 -
1RM5
4
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
94
PsiBlast_CBE
88.90
45%
-111
- C3 -
1RM5
5
G3PA_SPIOL
B:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
77
PsiBlast_CBE
88.77
45%
-113
- C3 -
1NBO
4
G3PA_SPIOL
A:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
74
PsiBlast_CBE
88.49
45%
-114
- C3 -
1RM4
5
G3PA_SPIOL
B:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
95
PsiBlast_CBE
88.46
45%
-115
- C3 -
1RM5
5
G3PA_SPIOL
A:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
91
PsiBlast_CBE
88.36
45%
-114
- C3 -
1RM3
5
G3PA_SPIOL
B:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
--
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
-
T
A
G
D
-
S
A
I
S
V
D
G
K
V
I
K
V
V
S
-
D
R
N
P
V
N
L
P
W
---
G
DMG
I
---
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
LQA
G
A
-
K
---
K
--
V
L
I
T
A
P
G
K
-
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
H
-
A
-
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
-
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
-
E
E
V
N
A
A
F
----
R
E
----
S
-----------
A
-----------
D
----
N
ELKG
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
-
M
-
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
-
4
PsiBlast_PDB
88.29
48%
-107
- C3 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
--
S
W
G
R
--
E
E
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
--
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
-
Q
K
D
P
S
Q
I
P
W
---
G
DLG
V
---
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
---
L
Q
-
G
GAK
K
--
V
I
I
T
A
P
A
K
-
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
-
E
-
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
-
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
-
P
S
S
V
E
E
V
N
E
K
F
----
R
E
----
A
A
Q
K
Y
R
E
SGKVY
L
-----------
K
----
E
----
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
-
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
32
PsiBlast_CBE
88.02
48%
-104
- C3 -
2EP7
1
G3P_AQUAE
B:
[2-340]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
--
S
W
G
R
--
E
E
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
--
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
-
Q
K
D
P
S
Q
I
P
W
---
G
DLG
V
---
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
---
L
Q
-
G
GAK
K
--
V
I
I
T
A
P
A
K
-
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
-
E
-
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
-
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
-
P
S
S
V
E
E
V
N
E
K
F
----
R
E
----
A
A
Q
K
Y
R
E
SGKVY
L
-----------
K
----
E
----
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
-
D
-
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
126
HHSearch
87.42
40%
-119
- C3 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
R
----
P
N
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
V
S
H
-
D
-
D
-
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
-
E
R
D
P
A
N
L
P
W
---
G
SSN
V
---
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
---
I
D
A
G
AK-
K
--
V
V
I
T
A
P
S
S
-
T
-
A
P
-
M
F
V
M
G
V
N
E
E
K
Y
-
T
S
-
D
-
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
-
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H-
K
D
W
R
G
G
-
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
E
-
T
T
Y
-
D
E
I
K
K
V
V
----
K
A
----
A
-----------
A
-----------
E
G
KLK
G
----
V
L
G
Y
T
E
D
A
V
V
S
-
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
-
L
-
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
A
--
66
PsiBlast_CBE
86.77
47%
-104
- C3 -
1HDG
3
G3P_THEMA
Q:
[2-324]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
N
P
D
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
--
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
-
E
P
D
P
S
K
L
P
W
---
K
DLG
V
---
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
LQA
G
A
-
K
---
K
--
V
I
I
T
A
P
A
K
-
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
-
E
-
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
-
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
----
K
E
----
A
TEGR-------
L
-----------
K
----
G
----
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
-
I
G
G
-
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
16
PsiBlast_PDB
86.73
47%
-104
- C3 -
1HDG
3
G3P_THEMA
O:
[2-324]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
N
P
D
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
--
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
-
E
P
D
P
S
K
L
P
W
---
K
DLG
V
---
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
LQA
G
A
-
K
---
K
--
V
I
I
T
A
P
A
K
-
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
-
E
-
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
-
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
-
E
E
V
N
A
V
M
----
K
E
----
A
TEGR-------
L
-----------
K
----
G
----
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
-
I
G
G
-
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
122
HHSearch
86.08
42%
-116
- C3 -
3CPS
1
?
A:
[18-352]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
R
----
N
D
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
V
E
V
-
S
-
G
--
D
L
C
I
N
G
K
V
V
K
V
F
Q
-
A
K
D
P
A
E
I
P
W
---
G
ASG
A
---
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
---
L
K
G
G
AK-
K
--
V
I
I
S
A
P
P
K
-
D
N
V
P
-
M
Y
V
M
G
V
N
N
T
E
Y
-
D
P
S
K
-
F
-
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
-
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
KG-
D
W
R
A
G
-
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
P
-
A
S
I
-
E
E
I
Y
Q
A
V
----
K
E
----
A
-----------
S
-----------
N
GPMK
G
----
I
M
G
Y
T
S
D
D
V
V
S
-
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
-
L
-
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
-
129
HHSearch
82.24
38%
-113
- C3 -
3H9E
10
G3PT_HUMAN
O:
[6-338]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
-----
G
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
G
S
V
E
F
-
R
-
N
-
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
-
C
K
E
P
K
Q
I
P
W
---
R
AVG
S
---
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
---
I
S
A
G
AQ-
R
--
V
V
I
S
A
P
S
P
-
D
-
A
P
-
M
F
V
M
G
V
N
E
N
D
Y
-
N
P
G
S
-
M
-
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
-
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R-
K
A
W
R
D
G
-
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
-
S
A
I
K
E
A
V
----
K
A
----
A
-----------
A
-----------
K
GPMA
G
----
I
L
A
Y
T
E
D
E
V
V
S
-
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
-
L
-
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
-