@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0158: (2016-03-12 )
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVSYYNYGNIFNFIDK
Atome Classification :
(20 SA)
----.........10........20..--.--.....30..----..----....40.....--...50........60.......-----.70---.---.-----......80.....---.---..90........100.......---110.......120.......130..-----.-.--..--.140..-.....150.......160......-.170---.-----.-.-----.-----....180.......-190.--..-..-....200.......210.......220.......230.......240..----.--.--..--.----250.......260----....-----...270--.-----.------.--.---.....-280...----...----.290...----....-300---------.----.......310.......320......-.330...-....340....------.---------..--------350-.--------.----------------..-----------....---------------360.......370.......380--..-..--.-.-.390-.-----........400.-----.---......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----
M
K
L
T
V
V
G
LGYIGL
P
T
S
I
M
F
A
KHG--
V
--
D
V
L
G
VDI
N
Q
----
Q
T
----
I
D
K
L
QSG
Q
I
S
I--EEP
G
L
Q
E
V
Y
E
E
V
L
SSG
K
L
K
V
ST-----TPE---A---S-----
D
V
F
I
I
A
VPTPNND---
D
---
Q
YRSC
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
E---KG
N
T
I
I
V
ESTIAP
K
T
M
D
D
F
V
K
P
V
I
E
-----N-L--GF--TIGE
D
I
-
C
L
V
HC
P
E
RVL
P
G
K
I
L
E
E
L
V
HNNR
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
EA
G
K
Y
V
Y
R
T
F
VQ-G--E--MI-ET-D
A
R
T
A
E
M
S
K
L
M
E
N
TYRD
V
N
I
A
L
A
N
E
L
T
K
I
C
NNLNI
N
V
L
D
V
I
E
M
ANKHPR----
V
--
N
--
I
H--Q----PGPGVGG
H
C
L
A
VD----
P
Y
F
I
-----
I
A
KD----P-----E------N--
A
---
K
L
I
QT-
G
R
E
INN----SM
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------L----SGN
K
V
T
V
F
G
L
T
YKG
D
V
D
D
IRESP
A
F
D
-
I
Y
E
L
LNQ-EPD
I
E
V
C
AYDP------H---------V
E
--------
L
-
D
-
F
--------
V
----------------
E
H
-----------
D
M
S
H
---------------AVKD
A
S
L
V
L
I
LSD
H
S
E
FKNL
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
FD
T
K
N
V
V
K
-
S
S-----F---EDVSYYNYG
N
I
F
N
FIDK--
21
PsiBlast_CBE
99.45
98%
-126
- C1 -
3OJO
7
?
B:
[13-429]
-----
K
L
T
V
V
G
L
G
Y
I
G
L
P
T
S
I
M
F
A
K
H
G
--
V
--
D
V
L
G
V
D
I
N
Q
----
Q
T
----
I
D
K
L
Q
N
G
Q
I
S
I
--
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-----
T
P
E
---
A
---
S
-----
D
V
F
I
I
A
V
P
T
P
N
N
D
---
D
---
Q
Y
R
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
F
V
K
P
V
I
E
-----
N
-
L
--
G
F
--
T
I
G
E
D
I
-
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
E
A
G
K
R
V
Y
R
T
F
V
Q
-
G
--
E
--
M
I
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T
-
D
A
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
I
E
M
A
N
K
H
P
R
----
V
--
N
--
I
H
--
Q
----
P
G
P
G
V
G
G
H
C
L
A
V
D
----
P
Y
F
I
-----
I
A
K
D
----
P
-----
E
------
N
--
A
---
K
L
I
Q
T
-
G
R
E
I
N
N
----
S
M
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------
L
----
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
-
I
Y
E
L
L
N
Q
-
E
P
D
I
E
V
C
A
Y
D
P
------
H
---------
V
E
--------
L
-
D
-
F
--------
V
----------------
E
H
-----------
D
M
S
H
---------------
A
V
K
D
A
S
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
F
D
T
K
N
V
V
K
-
S
S
-----
F
---
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
F
I
----
1
PsiBlast_PDB
99.01
98%
-122
- C1 -
3OJL
1
?
A:
[13-429]
-----
K
L
T
V
V
G
L
G
Y
I
G
L
P
T
S
I
M
F
A
K
H
G
--
V
--
D
V
L
G
V
D
I
N
Q
----
Q
T
----
I
D
K
L
Q
N
G
Q
I
S
I
--
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-----
T
P
E
---
A
---
S
-----
D
V
F
I
I
A
V
P
T
P
N
N
D
---
D
---
Q
Y
R
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
F
V
K
P
V
I
E
-----
N
-
L
--
G
F
--
T
I
G
E
D
I
-
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
E
A
G
K
R
V
Y
R
T
F
V
Q
-
G
--
E
--
M
I
-
E
T
-
D
A
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
I
E
M
A
N
K
H
P
R
----
V
--
N
--
I
H
--
Q
----
P
G
P
G
V
G
G
H
C
L
A
V
D
----
P
Y
F
I
-----
I
A
K
D
----
P
-----
E
------
N
--
A
---
K
L
I
Q
T
-
G
R
E
I
N
N
----
S
M
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------
L
----
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
-
I
Y
E
L
L
N
Q
-
E
P
D
I
E
V
C
A
Y
D
P
------
H
---------
V
E
--------
L
-
D
-
F
--------
V
----------------
E
H
-----------
D
M
S
H
---------------
A
V
K
D
A
S
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
F
D
T
K
N
V
V
K
-
S
S
-----
F
---
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
F
I
----
2
PsiBlast_PDB
97.47
98%
-123
- C1 -
3OJO
7
?
A:
[13-429]
-----
K
L
T
V
V
G
L
G
Y
I
G
L
P
T
S
I
M
F
A
K
H
G
--
V
--
D
V
L
G
V
D
I
N
Q
----
Q
T
----
I
D
K
L
Q
N
G
Q
I
S
I
--
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-----
T
P
E
---
A
---
S
-----
D
V
F
I
I
A
V
P
T
P
N
N
D
---
D
---
Q
Y
R
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
F
V
K
P
V
I
E
-----
N
-
L
--
G
F
--
T
I
G
E
D
I
-
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
E
A
G
K
R
V
Y
R
T
F
V
Q
-
G
--
E
--
M
I
-
E
T
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D
A
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A
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M
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K
L
M
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N
T
Y
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V
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I
A
L
A
N
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L
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K
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C
N
N
L
N
I
N
V
L
D
V
I
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M
A
N
K
H
P
R
----
V
--
N
--
I
H
--
Q
----
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G
P
G
V
G
G
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C
L
A
V
D
----
P
-----------------------------
N
--
A
---
K
L
I
Q
T
-
G
R
E
I
N
N
----
S
M
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------
L
----
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
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P
A
F
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-
I
Y
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L
L
N
Q
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A
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P
------
H
---------
V
E
--------
L
-
D
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F
--------
V
----------------
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H
-----------
D
M
S
H
---------------
A
V
K
D
A
S
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
F
D
T
K
N
V
V
K
-
S
S
-----
F
---
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
F
I
----
23
HHSearch
97.09
97%
-125
- C1 -
3OJO
7
?
A:
[12-429]
----
S
K
L
T
V
V
G
L
G
Y
I
G
L
P
T
S
I
M
F
A
K
H
G
--
V
--
D
V
L
G
V
D
I
N
Q
----
Q
T
----
I
D
K
L
Q
N
G
Q
I
S
I
--
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-----
T
P
E
---
A
---
S
-----
D
V
F
I
I
A
V
P
T
P
N
N
D
---
D
---
Q
Y
R
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
F
V
K
P
V
I
E
-----
N
-
L
--
G
F
--
T
I
G
E
D
I
-
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
E
A
G
K
R
V
Y
R
T
F
V
--
Q
--
G
--
E
M
I
E
T
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D
A
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
I
E
M
A
N
K
H
P
R
----
V
--
N
--
I
H
--
Q
----
P
G
P
G
V
G
G
H
C
L
A
V
D
----
P
-----------------------------
N
--
A
---
K
L
I
Q
T
-
G
R
E
I
N
N
----
S
M
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------
L
----
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
-
I
Y
E
L
L
N
Q
E
P
-
D
I
E
V
C
A
Y
D
P
------
H
---------
V
E
--------
L
-
D
-
F
--------
V
----------------
E
H
-----------
D
M
S
H
---------------
A
V
K
D
A
S
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
F
D
T
K
N
V
V
K
-
S
S
-----
F
---
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
F
I
----
22
PsiBlast_CBE
96.92
98%
-122
- C1 -
3OJL
1
?
B:
[13-430]
-----
K
L
T
V
V
G
L
G
Y
I
G
L
P
T
S
I
M
F
A
K
H
G
--
V
--
D
V
L
G
V
D
I
N
Q
----
Q
T
----
I
D
K
L
Q
N
G
Q
I
S
I
--
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-----
T
P
E
---
A
---
S
-----
D
V
F
I
I
A
V
P
T
P
N
N
D
---
D
---
Q
Y
R
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
F
V
K
P
V
I
E
-----
N
-
L
--
G
F
--
T
I
G
E
D
I
-
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
-
I
G
G
----
V
-----
T
-
K
-----
A
-----
C
I
E
A
G
K
R
V
Y
R
T
F
V
Q
-
G
--
E
--
M
I
-
E
T
-
D
A
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
I
E
M
A
N
K
H
P
R
----
V
--
N
--
I
H
--
Q
----
P
G
P
G
V
G
G
H
C
L
A
V
D
----
P
Y
F
---------------------------
N
--
A
---
K
L
I
Q
T
-
G
R
E
I
N
N
----
S
M
P
----
A
Y
V
V
D
T
T
----
K
Q
I
I
-
K
A
----------
L
----
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
-
I
Y
E
L
L
N
Q
-
E
P
D
I
E
V
C
A
Y
D
P
------
H
---------
V
E
--------
L
-
D
-
F
--------
V
----------------
E
H
-----------
D
M
S
H
---------------
A
V
K
D
A
S
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
--
H
F
-
D
K
--
M
-
K
-
H
K
---
V
-----
I
F
D
T
K
N
V
V
K
-
S
S
-----
F
---
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
F
I
D
---
10
PsiBlast_PDB
73.83
26%
-98
- C1 -
3GG2
4
?
A:
[3-436]
----
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
----
N
K
----
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
---
A
---------
D
I
I
F
I
A
V
G
T
P
A
G
E
---
D
---
G
--
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
Q
E
-----
E
-
L
D
-
K
R
--
E
V
L
I
D
F
-
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
-
V
V
G
----
V
D----
S
-
D
-----
R
-----
A
R
E
L
I
T
S
L
Y
K
P
M
L
L
-
N
NF
R
--
V
L
-
F
M
-
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
----
I
--
G
SK
F
L
--
Y
----
P
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
K
A
L
-----
I
R
T
A
----
E
-----
D
------
N
--
G
YRM
E
V
L
E
A
-
V
E
R
V
N
E
----
K
Q
K
----
S
I
L
F
D
K
F
----
S
T
Y
Y
-
K
G
N---------
V
----
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
-
L
I
E
K
L
-
L
-
E
V
G
C
R
V
R
V
Y
D
P
VA
M
K
E
A
Q
---------
K
R
--------
L
G
D
-
K
--------
V
----------------
E
Y
T
T---------
D
M
Y
D
---------------
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
--
A
L
-
S
Q
A
-
M
-
A
-
A
S
---
L
-----
V
I
D
G
R
N
V
Y
E
L
P
------------
F
T
L
L
N
I
G
----------
29
HHSearch
70.86
26%
-89
- C1 -
3GG2
4
?
A:
[3-436]
----
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
--
A
--
N
V
R
C
I
D
T
D
R
----
N
K
----
I
E
Q
L
N
S
G
T
I
P
I
--
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
-
A
V
P
---
E
---
A
-----
D
I
I
F
I
A
V
G
T
P
A
G
E
--------
D
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
-
I
Q
-----
E
-
E
L
D
K
R
--
E
V
L
I
D
F
-
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
-
V
V
G
----
V
-----
D
-
S
D
----
R
-----
A
R
E
L
I
T
S
L
Y
K
P
M
L
--
L
--
N
NF
R
V
L
F
M
-
D
I
A
S
A
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M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
----
I
GS
K
--
F
L
--
Y
----
P
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
K
A
L
-----
I
R
T
A
----
E
-----
D
N
GY---
R
--
M
---
E
V
L
E
A
-
V
E
R
V
N
E
----
K
Q
K
----
S
I
L
F
D
K
F
----
S
T
Y
Y
-
K
G
----------
N
V---
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
-
L
I
E
K
L
L
E
-
V
-
G
C
R
V
R
V
Y
D
P
------
V
---------
A
M
--------
K
-
E
A
Q
K
R
LGDK
V
E
Y
----------------
T
T
-----------
D
M
Y
D
---------------
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
--
A
L
-
S
Q
A
-
M
-
A
-
A
S
---
L
-----
V
I
D
G
R
N
V
Y
E
-
L
P
-----------
F
T
L
L
N
I
G
----------
4
PsiBlast_PDB
70.31
28%
-97
- C1 -
4XR9
3
?
A:
[16-433]
----
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
L
A
V
T
L
A
G
R
G
--
A
--
E
V
V
A
V
D
S
D
P
----
G
T
----
V
A
D
L
R
A
G
R
C
R
L
--
P
E
P
G
L
A
G
A
V
R
D
L
A
A
T
G
R
L
T
A
S
T
-----
S
Y
D
PVG
A
---
A
-----
D
V
V
I
V
T
V
G
T
P
T
D
A
---
G
---
H
E
M
V
T
D
--
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
L
V
A
P
L
L
E
-----
S
-
G
--
G
L
--
V
H
E
R
D
F
-
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
-
V
G
G
----
C
-----
G
-
P
-----
R
-----
S
A
A
A
A
E
R
F
W
R
S
A
L
G
-
V
--
D
--
V
R
-
Q
V
P
S
A
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
I
G
A
A
N
T
L
P
K
GSSM
V
--
N
--
L
L
--
L
----
P
G
V
G
V
G
G
S
C
L
T
K
D
----
P
W
M
A
-----
W
R
D
G
----
R
-----
D
------
R
--
G
VSL
R
T
V
E
T
-
A
R
A
V
N
D
----
D
M
P
R
H
T
A
A
V
I
A
D
E
L
----
V
K
L
G
-
R
D
----------
R
----
N
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
-
V
V
A
A
L
-
R
-
D
S
G
F
R
V
R
I
F
D
P
------
L
---------
A
D
P
-------
A
-
E
-
I
--------
V
----------------
A
R
FGTAPAA----
S
L
D
E
---------------
A
V
S
G
A
G
C
L
A
F
L
A
G
H
R
Q
F
H
E
L
D
-----
F
-
G
A
--
L
-
A
-
E
R
---
V
DEP
C
L
V
F
D
G
R
-----------------------------------
24
HHSearch
69.32
27%
-88
- C1 -
2Y0C
11
?
A:
[9-460]
----
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
----
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
-
A
V
A
---
H
---
G
-----
D
V
Q
F
I
A
V
G
T
P
P
D
E
--------
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
-
V
A
-----
E
-
E
--
L
A
K
R
G
G
D
Q
M
F
-
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
-
V
I
G
----
C
-----
D
-
D
D
V
P
G
E
R
-----
A
R
E
L
M
K
K
L
Y
A
P
F
N
--
R
NH
E
--
R
T
L
Y
M
-
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
----
I
GY
H
--
F
L
--
Y
----
A
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
E
A
L
-----
I
R
T
A
----
D
-----
E
H
GQ---
S
--
L
---
Q
I
L
K
A
-
V
S
S
V
N
A
----
T
Q
K
----
R
V
L
A
D
K
I
----
V
A
R
F
-
G
E
----------
D
L---
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
-
L
I
A
E
L
L
S
-
R
-
G
A
R
I
A
A
Y
D
P
------
V
---------
A
Q
--------
E
-
E
A
R
R
V
------
I
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
-----------
D
E
A
Q
---------------
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
--
A
L
-
G
R
L
-
W
-
K
-
T
P
---
V
-----
I
F
D
G
R
N
L
Y
E
-
P
E
-----
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
--------
6
PsiBlast_PDB
67.97
28%
-83
- C1 -
2Y0E
10
?
A:
[9-441]
----
M
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
----
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
-----
D
I
E
---
A
---
A
V
A
H
G-
D
V
Q
F
I
A
V
G
T
P
P
D
E
---
D
---
G
--
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
-----
E
-
L
--
A
K
--
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
-
V
I
G
----
C
D
DD
V
P
G
-
E
-----
R
-----
A
R
E
L
M
K
K
L
Y
A
P
F
N
R
-
N
HE
R
--
T
L
-
Y
M
-
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
----
I
--
G
--
Y
H
FL
Y
----
A
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
E
A
L
-----
I
R
T
A
----
D
-----
E
------
H
--
G
---
Q
S
L
Q
I
-
L
K
A
V
S
S
--------------
V
N
A
T
----
Q
K
R
V
-
L
A
D
K
I
V
A
R
FGED
L
----
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
---
G
A
R
I
A
A
Y
D
P
------
V
---------
A
Q
E
E
A
R
R
V
I
A
L
-
D
-
L
--------
A
----------------
D
H
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
---------------
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
--
A
L
-
G
R
--
L
W
K
-
T
P
---
V
-----
I
F
D
G
R
N
L
---------------------------------
8
PsiBlast_PDB
67.95
27%
-83
- C1 -
2Y0D
7
?
A:
[9-441]
----
M
N
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
----
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
-----
D
I
E
---
A
---
A
V
A
H
G-
D
V
Q
F
I
A
V
G
T
P
P
D
E
----------
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
-----
E
-
L
--
A
K
--
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
-
V
I
G
----
C
D
DD
V
P
G
-
E
-----
R
-----
A
R
E
L
M
K
K
L
Y
A
P
F
N
R
-
N
HE
R
--
T
L
-
Y
M
-
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
----
I
--
G
--
Y
H
FL
Y
----
A
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
E
A
L
-----
I
R
T
A
----
D
-----
E
------
H
--
G
---
Q
S
L
Q
I
-
L
K
A
V
S
S
--------------
V
N
A
T
----
Q
K
R
V
-
L
A
D
K
I
V
A
R
FGED
L
----
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
---
G
A
R
I
A
A
Y
D
P
------
V
---------
A
Q
E
E
A
R
R
V
I
A
L
-
D
-
L
--------
A
----------------
D
H
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
---------------
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
--
A
L
-
G
R
--
L
W
K
-
T
P
---
V
-----
I
F
D
G
R
N
L
---------------------------------
7
PsiBlast_PDB
67.83
27%
-84
- C1 -
2Y0C
11
?
A:
[9-441]
----
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
--
H
--
D
V
F
C
L
D
V
D
Q
----
A
K
----
I
D
I
L
N
N
G
G
V
P
I
--
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
-----
D
I
E
---
A
---
A
V
A
H
G-
D
V
Q
F
I
A
V
G
T
P
P
D
E
---
D
---
G
--
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
-----
E
-
L
--
A
K
--
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
-
V
I
G
----
C
D
DD
V
P
G
-
E
-----
R
-----
A
R
E
L
M
K
K
L
Y
A
P
F
N
R
-
N
HE
R
--
T
L
-
Y
M
-
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
----
I
--
G
--
Y
H
FL
Y
----
A
G
C
G
Y
G
G
S
C
F
P
K
D
----
V
E
A
L
-----
I
R
T
A
----
D
-----
E
------
H
--
G
---
Q
S
L
Q
I
-
L
K
A
V
S
S
--------------
V
N
A
T
----
Q
K
R
V
-
L
A
D
K
I
V
A
R
FGED
L
----
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
---
G
A
R
I
A
A
Y
D
P
------
V
---------
A
Q
E
E
A
R
R
V
I
A
L
-
D
-
L
--------
A
----------------
D
H
P
S
W
L
E
R
L
S
F
V
D
D
E
A
Q
---------------
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
--
A
L
-
G
R
--
L
W
K
-
T
P
---
V
-----
I
F
D
G
R
N
L
---------------------------------
28
HHSearch
66.56
30%
-98
- C1 -
3G79
-
?
A:
[19-471]
----
K
K
I
G
V
L
G
M
G
Y
V
G
I
P
A
A
V
L
F
A
D
A
P
CF
E
--
K
V
L
G
F
Q
R
N
S
KSS
G
Y
K
----
I
E
M
L
N
R
G
E
S
P
L
K
G
E
E
P
G
L
E
E
L
I
G
K
V
V
K
A
G
K
F
E
C
T
P
DFS--
R
I
S
---
E
---
L
-----
D
A
V
T
L
A
I
Q
T
P
F
A
N
---
P
---
K
D
L
E
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L
K
---
P
G
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
M
A
K
Q
I
L
E
-----
E
E
S
--
G
L
--
K
A
G
E
D
F
-
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
-
V
G
G
----
I
-----
D
-
E
-----
A
-----
S
T
K
R
A
V
E
L
Y
S
P
V
L
--
T
V-
G
--
Q
V
I
P
M
-
S
A
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
R
T
G
V
D
S
L
K
G
EG--
I
TR
A
--
V
L
--
W
----
P
G
A
G
V
G
G
H
C
L
T
K
D
----
T
Y
H
L
-----
E
R
G
V
----
K
IGR
G
-
E
L
D
Y
P
E
G
A
--
D
---
S
I
Y
V
L
-
A
R
K
V
N
D
----
F
M
P
----
A
H
M
Y
N
L
T
----
V
A
A
L
-
E
R
----------
L
GKKM
D
G
S
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
E
P
-
Y
R
D
L
C
L
K
-
A
-
G
A
S
V
M
V
H
D
P
------
Y
---------
V
V
--------
N
-
Y
P
G
V
E
------
I
----------------
S
D
-----------
N
L
E
E
---------------
V
V
R
N
A
D
A
I
V
V
L
A
G
H
S
A
Y
S
S
L
K
A
D
W
A
K
K
-
V
S
A-
K
-
A
-
N
P
---
V
-----
I
I
D
G
R
N
V
I
E
-
P
D
-----
E
F
I
G
K
G
F
V
Y
K
G
I
G
R
E
--------
3
PsiBlast_PDB
66.42
30%
-102
- C1 -
3G79
-
?
A:
[20-454]
-----
K
I
G
V
L
G
M
G
Y
V
G
I
P
A
A
V
L
F
A
D
A
P
--
C
FE
K
V
L
G
F
Q
R
N
S
----
K
S
S
G
Y
K
I
E
M
L
N
R
G
E
S
P
L
K
G
E
E
P
G
L
E
E
L
I
G
K
V
V
K
A
G
K
F
E
C
-------
T
P
D
---
F
---
S
RISEL
D
A
V
T
L
A
I
Q
T
P
F
A
N
---
P
---
K
D
L
E
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L
K
---
P
G
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
M
A
K
Q
I
L
E
-----
E
E
S
--
G
L
--
K
A
G
E
D
F
-
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
-
V
G
G
----
I
-----
D
-
E
-----
A
-----
S
T
K
R
A
V
E
L
Y
S
P
V
L
T
V
G
--
Q
--
V
I
-
P
M
-
S
A
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
R
T
G
V
D
S
L
K
G
----
E
--
G
--
I
T
--
R
A
V
L
W
P
G
A
G
V
G
G
H
C
L
T
K
D
----
T
Y
H
L
E
R
G
V
K
I
G
R
G
E
L
D
Y
P
-----
E
------
G
--
A
---
D
S
I
Y
V
L
A
R
K
V
N
D
----
F
M
P
----
A
H
M
Y
N
L
T
V
A
A
L
E
R
L
G
-
K
K
----------
M
----
D
G
S
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
-
E
-
P
Y
R
D
L
C
L
-
K
A
G
A
S
V
M
V
H
D
P
------
Y
---------
V
---------
V
-
N
-
Y
PG
V
E
----
I
----------------
S
D
-----------
N
L
E
E
---------------
V
V
R
N
A
D
A
I
V
V
L
A
G
H
S
A
Y
S
S
L
K
A
D
--
W
A
-
K
K
--
V
-
S
-
A
K
A
N
P
V
-----
I
I
D
G
R
N
V
I
E
-------------------------------
27
HHSearch
65.13
27%
-82
- C1 -
3VTF
2
?
A:
[22-444]
----
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
--
H
--
R
V
V
G
Y
D
V
N
P
----
S
I
----
V
E
R
L
R
A
G
R
P
H
I
--
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
-
A
V
A
---
A
---
T
-----
D
A
T
F
I
A
V
G
T
P
P
A
P
--------
D
G
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
V
A
R
-
A
V
-----
A
-
E
--
E
A
--
G
-
G
V
K
F
-
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
-
V
I
G
A---
G
-----
D
-
E
-----
R
-----
A
A
S
F
L
L
D
V
Y
K
A
V
D
--
A
--
P
--
K
L
-
V
M
-
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
----
I
GR
H
--
Y
F
--
G
----
A
G
L
G
F
G
G
S
C
F
P
K
D
----
T
L
A
F
-----
I
R
F
G
----
E
-----
S
L
GL---
E
--
M
---
A
I
S
K
A
-
V
L
R
V
N
E
----
Y
M
P
----
R
Y
A
V
Q
L
L
----
E
E
R
L
-
G
G
----------
L
----
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
-
V
A
R
L
L
L
E
-
R
-
G
A
R
V
Y
V
H
D
P
------
M
---------
A
M
--------
E
-
K
A
R
A
V
LGDS
V
T
Y
----------------
V
E
-----------
D
P
Q
A
---------------
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
Y
R
-------------
G
K
---
V
-----
V
V
D
G
R
Y
V
K
K
-
A
R
---------
E
A
K
I
Y
E
G
V
A
W
A
--------
16
PsiBlast_PDB
64.86
23%
-95
- C1 -
3TDK
3
UGDH_HUMAN
A:
[6-445]
-----
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
PE
I
--
R
V
T
V
V
D
V
N
E
----
S
R
----
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C
R
G
K
N
L
F
F
S
T
N
-----
I
D
D
---
A
I
K
E
A
-----
D
L
V
F
I
S
V
N
T
P
T
K
T
YGM
G
---
K
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
-
S
---
N
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
R
R
I
F
D
A
N
TKP
N
-
L
--
N
L
--
Q
V
-------
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
ET
P
E
-----
G
-
Q
-----
R
-----
A
V
Q
A
L
C
A
V
Y
E
H
W
V
P
-
R
--
E
--
K
I
L
T
T
-
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
----
I
GN
K
--
F
L
--
K
----
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
-----
E
A
L
N
L---
P
-----
E
------
V
--
A
---
R
Y
W
Q
Q
-
V
I
D
M
N
D
Y
Q
R
R
R
F
A
----
S
R
I
I
D
S
-------
L
F
-
N
T
----------
V
----
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
-
I
S
K
Y
L
M
D
-
E
-
G
A
H
L
H
I
Y
D
P
------
K
---------
V
P
--------
R
-
E
-
Q
--------
I
----------------
V
V
-----------
D
L
S
H
DQVSRL
V
T
I
S
KD
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
--
R
I
-
H
K
K
M
L
-
K
-
P
A
---
F
-----
I
F
D
G
R
R
V
L
--------------------------------
11
PsiBlast_PDB
64.63
25%
-87
- C1 -
4A7P
1
?
A:
[9-424]
----
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
--
H
--
E
V
V
C
V
D
K
D
A
----
R
K
----
I
E
L
L
H
Q
N
V
M
P
I
--
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
-
G
V
K
---
D
---
A
-----
D
A
V
F
I
A
V
G
T
P
S
R
R
---
G
---
D
G
H
A
-
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
V
I
V
T
K
S
T
V
-
P
V
G
T
G
D
E
V
E
R
I
I
A
-----
E
-
V
--
A
P
--
N
S
G
A
K
V
---
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
-
V
V
G
----
T
-----
E
D
E
-----
F
-----
A
R
Q
V
M
R
E
I
Y
R
P
L
S
-----
P
--
V
L
-
F
T
-
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
----
I
---F-
L
H
--
A
-----
G
P
G
Y
G
G
S
C
F
P
K
D
----
T
L
A
L
-----
M
K
T
A
----
A
-----
D
------
N
--
E
TPL
R
I
V
E
A
-
T
V
Q
V
N
D
----
A
R
K
----
R
A
---
M
G
----
R
K
V
I
-
K
A
M
GGD------
V
----
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
-
I
I
A
A
L
-
Q
-
D
A
G
A
T
V
K
A
Y
D
P
------
E
GV
E
Q
A
S
K
M
L
T
D
--------
V
-
E
-
F
--------
V
----------------
E
N
-----------
P
Y
A
----------------
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
--
R
I
K
N
S
--
L
-
K
-
S
P
---
V
-----
L
V
D
L
R
N
I
---------------------------------
26
HHSearch
64.36
24%
-85
- C1 -
2Q3E
3
UGDH_HUMAN
A:
[6-466]
----
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
PE
I
--
R
V
T
V
V
D
V
N
E
----
S
R
----
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C
R
-
G
K
N
L
F
F
S
T
N
I
D
D
-
A
I
K
---
E
---
A
-----
D
L
V
F
I
S
V
N
T
P
T
K
T
---
Y
GMG
K
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
R
R
-
I
F
D
-----
A
-
N
--
T
K
--
P
N
-
L
N
L
-
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
-
L
I
G
----
G
-----
D
-
E
-----
T
P
E
G
Q
R
A
V
Q
A
L
C
A
V
Y
E
H
W
V
--
P
R-
E
--
K
I
L
T
T
-
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
----
I
GN
K
--
F
L
--
K
----
A
S
V
G
F
G
G
S
C
F
Q
K
D
----
V
L
N
L
-----
V
Y
L
C
----
E
-----
A
L
NL---
P
E
V
A
---
R
Y
W
Q
Q
-
V
I
D
M
N
D
----
Y
Q
R
----
R
R
F
A
S
R
I
----
I
D
S
L
-
F
N
----------
T
V---
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
-
I
S
K
Y
L
M
D
-
E
-
G
A
H
L
H
I
Y
D
P
------
K
---------
V
P
--------
R
-
E
Q
I
V
V
------
D
L
SHDQVSRL
V
T
I
----
S
K
-----------
D
P
Y
E
---------------
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
--
R
I
-
H
K
K
-
M
-
L
K
P
A
---
F
-----
I
F
D
G
R
R
V
L
D
-
G
L
H
N
E
L
Q
T
---
I
G
F
Q
I
E
T
I
G
K
K
--------
44
Fugue
63.70
24%
-87
- C1 -
2Q3E
3
UGDH_HUMAN
A:
[2-467]
MFEI
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
PE
I
--
R
V
T
V
V
D
V
N
E
----
S
R
----
I
N
A
W
N
S
P
T
L
P
I
--
Y
E
P
G
L
K
E
V
V
E
S
C
-
R
G
K
N
L
F
F
S
T
N
I
D
D
-
A
I
K
---
E
---
A
-----
D
L
V
F
I
S
V
N
T
P
T
K
T
---
Y
GMG
K
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
I
R
R
I
F
D
A
-----
N
-
T
--
K
P
--
N
L
--
N
L
-
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
-
L
I
G
----
G
D
ET
P
E
G
-
Q
-----
R
-----
A
V
Q
A
L
C
A
V
Y
E
H
W
V
P
-
R
--
E
K-
I
L
-
T
T
-
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
----
I
GN
K
--
F
L
--
K
----
A
S
V
G
F
G
G
S
C
F
Q
K
D
----
V
L
N
L
-----
V
Y
L
C
----
E
A
L
NL
P
E
------
V
--
A
---
R
Y
W
Q
Q
-
V
I
D
M
N
D
----
Y
Q
R
----
R
R
F
A
S
R
I
----
I
D
S
L
F
N
T
----------
V
----
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
-
I
S
K
Y
L
M
D
--
E
G
A
H
L
H
I
Y
D
P
------
K
---------
V
P
--------
R
-
E
-
Q
--------
I
----------------
V
V
-----------
D
L
S
H
DQVSRL
V
T
I
S
KD
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
--
R
I
-
H
K
--
K
-
M
-
L
K
P
A
-
F
-----
I
F
D
G
R
R
V
L
D
-
G
L
-----
H
---
N
E
L
Q
T
I
G
F
--
Q
I
E
T
I
G
K
KV
25
HHSearch
63.23
23%
-85
- C1 -
2O3J
4
UGDH_CAEEL
A:
[10-470]
----
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
T
C
A
M
I
A
H
K
C
PH
I
--
T
V
T
V
V
D
M
N
T
----
A
K
----
I
A
E
W
N
S
D
K
L
P
I
--
Y
E
P
G
L
D
E
I
V
F
A
A
R
-
G
R
N
L
F
F
S
S
D
I
P
K
-
A
I
A
---
E
---
A
-----
D
L
I
F
I
S
V
N
T
P
T
K
M
---
Y
GRG
K
G
M
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
I
G
C
I
-
L
R
-----
E
-
A
--
Q
K
-----
L
K
F
-
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
-
L
I
G
----
G
-----
E
-
S
S
P
---
E
G
L
Q
--
A
V
A
E
L
V
R
I
Y
E
N
W
V
P
-
R
--
N
--
R
I
I
T
T
-
N
T
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
A
H
A
V
G
Y
D
T
R
----
I
GS
K
--
F
L
--
Q
----
A
S
V
G
F
G
G
S
C
F
Q
K
D
----
V
L
S
L
-----
V
Y
L
C
----
E
-----
S
L
NL---
P
Q
V
A
---
D
Y
W
Q
G
-
V
I
N
I
N
N
----
W
Q
R
----
R
R
F
A
D
K
I
----
I
A
E
L
-
F
N
----------
T
V---
T
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
-
V
I
K
H
L
M
E
-
E
-
H
A
K
L
S
V
Y
D
P
------
K
---------
V
Q
--------
K
-
S
Q
M
L
N
D
-----
L
A
S
V
TS
A
Q
D
V
E
R
L
I
T
V
-
E
S
-----------
D
P
Y
A
---------------
A
A
R
G
A
H
A
I
V
V
L
T
E
W
D
E
F
V
E
L
N
Y
S
--
Q
I
-
H
N
D
-
M
-
Q
H
P
A
---
A
-----
I
F
D
G
R
L
I
L
D
-
Q
K
-----
A
L
R
E
I
G
F
R
T
F
A
I
G
T
S
P
D
------