@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1094: (2016-03-22 )
MTQTVNVIGAGLAGSEAAYQLAERGIKVNLIEMRPVKQTPAHHTDKFAELVCSNSLRGNALTNGVGVLKEEMRRLNSIIIEAADKARVPAGGALAVDRHDFSGYITETLKNHENITVINEEINAIPDGYTIIATGPLTTETLAQEIVDITGKDQLYFYDAAAPIIEKESIDMDKVYLKSRYDKGEAAYLNCPMTEDEFNRFYDAVLEAEVAPVNSFEKEKYFEGCMPFEVMAERGRKTLLFGPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGAQKEVIKLIPGLENVDIVRYGVMHRNTFINSPDVLNEKYELISQPNIQFAGQMTGVEGYVESAASGLVAGINLAHKILGKGEVVFPRETMIGSMAYYISHAKNNKNFQPMNANFGLLPSLETRIKDKKERYEAQANRALDYLENFKKTL
Atome Classification :
(20 SA)
--.........10........20....--.-...30....-------...-------.40-----.........50....----....60........70.----...-----.-----..-.80...---.----------.-.--------.----------.--90-.........100.......110----........120---------------------.----------------------.------------------....------..130.......140-----.---------------------........150.......160.......170.......180.-.-.--------------------------------....190..-.....200.......210--.--......---------220.......230.......240-------.......250.......260.......270.......280.......290.......300..-----.....310.......320.......330.......--------------340.......350.......360.......370-.....--------..380.......----------------------390.......400.....-..410.......420.......430...------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
T
Q
T
V
N
V
I
GAGLAG
S
E
A
A
Y
Q
L
A
ERG--
I
-
K
V
N
L
I
E
MRP-------VKQ-------TP------AH
H
T
D
K
F
A
E
L
V
C
SNS----LRGNALT
N
G
V
G
V
L
K
E
E
M
----
R
R
L
-----
N
-----
S
I
-
I
I
EAAD---K----------A-R--------V----------P--A--G
G
A
L
A
V
DRHDF
S
G
Y
I
T
E
T
LKN-----HE
N
I
T
V
I
N
E
E
----------------------I----------------------N------------------AIPD------
G
Y
T
I
I
ATGPL
T
T
E
-------
T
---------------------
L
A
Q
E
I
V
DITGKD
Q
L
Y
F
YDAAAPIIEKESI
D
M
D
K
V
Y
L
K
SRYDK-G-
E
--------------------------------
A
A
Y
L
NCPM
T
-
E
D
E
F
N
R
F
Y
D
A
V
L
EAEVAP--V--N
S
F
E
K
E
---------
K
Y
FEGCM
P
F
E
V
M
A
ERG
R
K
T
L
L
FG-------PMKPVGLEDPKTGKR
P
Y
A
V
V
Q
L
RQDDAAG
T
L
Y
N
I
VGF
Q
T
H
LKWG
A
Q
K
E
V
I
K
LIPGLENV
D
I
V
-----
R
Y
G
V
M
HRNTFINS
P
D
V
L
N
E
K
Y
E
L
ISQPN
I
Q
F
AGQM--------------TG
V
E
G
Y
V
E
S
A
A
S
G
L
V
A
G
I
N
L
A
H
K
ILGKG
E
V
V
F
P
-
R
E
T
M
I
--------
G
S
M
A
Y
Y
I
S
HAKN----------------------NKNFQPMNANFGLLP
S
L
E
-
T
R
I
K
D
K
K
E
R
Y
E
A
Q
A
N
R
A
L
D
Y
L
E
N
F
K
K
TL------------------------------
1
PsiBlast_PDB
88.07
54%
-82
- C6 -
3G5Q
2
TRMFO_THET8
A:
[2-431]
----
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
-
P
V
R
L
F
E
M
R
P
-------
K
R
M
-------
T
P
------
A
H
G
T
D
R
F
A
E
I
V
C
S
N
S
----
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
E
M
----
R
R
A
-----
G
-----
S
L
-
V
M
E
A
A
D
---
L
----------
A
-
R
--------
V
----------
P
--
A
--
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
-----
H
P
L
L
E
V
V
R
E
E
----------------------
V
----------------------
R
------------------
E
I
P
P
------
G
I
T
V
L
A
T
G
P
L
T
S
E
-------
A
---------------------
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
G
Q
---
S
--------------------------------
A
D
Y
L
N
C
P
M
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
----------------------------
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
-------
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
-----
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
--------------
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
P
-
E
E
S
M
L
--------
G
G
L
V
R
Y
L
A
T
A
-
N
----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
-
G
R
M
-
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
------------------------------
2
PsiBlast_PDB
88.06
54%
-83
- C6 -
3G5R
9
TRMFO_THET8
A:
[2-431]
----
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
-
P
V
R
L
F
E
M
R
P
-------
K
R
M
-------
T
P
------
A
H
G
T
D
R
F
A
E
I
V
C
S
N
S
----
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
E
M
----
R
R
A
-----
G
-----
S
L
-
V
M
E
A
A
D
---
L
----------
A
-
R
--------
V
----------
P
--
A
--
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
-----
H
P
L
L
E
V
V
R
E
E
----------------------
V
----------------------
R
------------------
E
I
P
P
------
G
I
T
V
L
A
T
G
P
L
T
S
E
-------
A
---------------------
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
G
Q
---
S
--------------------------------
A
D
Y
L
N
C
P
M
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
-----------------------------
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
-------
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
-----
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
--------------
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
P
-
E
E
S
M
L
--------
G
G
L
V
R
Y
L
A
T
A
-
N
----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
-
G
R
M
-
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
------------------------------
107
HHSearch
87.60
54%
-81
- C6 -
3G5S
8
TRMFO_THET8
A:
[1-431]
---
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
-
P
V
R
L
F
E
M
R
P
-------
K
R
M
-------
T
P
------
A
H
G
T
D
R
F
A
E
I
V
C
S
N
S
----
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
E
M
----
R
R
A
-----
G
-----
S
L
-
V
M
E
A
A
D
---
L
----------
A
-
R
--------
V
----------
P
--
A
--
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
-----
H
P
L
L
E
V
V
R
E
E
----------------------
V
----------------------
R
------------------
E
I
P
P
------
G
I
T
V
L
A
T
G
P
L
T
S
E
-------
A
---------------------
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
----------------------------------------
Y
L
N
C
P
M
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
--
P
--
H
----------------
F
E
A
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
-------
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
-----
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
--------------
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
P
-
E
E
S
M
L
--------
G
G
L
V
R
Y
L
A
T
A
N
-----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
-
G
R
-
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
------------------------------
3
PsiBlast_PDB
86.72
52%
-83
- C6 -
3G5S
8
TRMFO_THET8
A:
[2-431]
----
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
-
P
V
R
L
F
E
M
R
P
-------
K
R
M
-------
T
P
------
A
H
G
T
D
R
F
A
E
I
V
C
S
N
S
----
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
E
M
----
R
R
A
-----
G
-----
S
L
-
V
M
E
A
A
D
---
L
----------
A
-
R
--------
V
----------
P
--
A
--
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
-----
H
P
L
L
E
V
V
R
E
E
----------------------
V
----------------------
R
------------------
E
I
P
P
------
G
I
T
V
L
A
T
G
P
L
T
S
E
-------
A
---------------------
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
----------------------------------------
Y
L
N
C
P
M
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
--
P
--
H
----------------
F
E
A
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
-------
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
-----
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
--------------
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
P
-
E
E
S
M
L
--------
G
G
L
V
R
Y
L
A
T
A
-
N
----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
-
G
R
-
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
------------------------------
110
HHSearch
62.96
25%
-66
- C6 -
3CP8
1
MNMG_CHLTE
A:
[20-489]
--
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
--
L
-
H
C
L
L
I
T
S
D
L
-------
S
----------------------
A
V
A
R
M
S
C
N
P
A
----
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
----
D
A
L
-----
G
-----
G
E
-
M
G
K
A
I
D
---
A
----------
T
-
G
--------
I
Q
F
R
M
L
NRSKG
P
--
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
-----
E
P
N
I
D
L
L
Q
D
T
----------------------
V
----------------------
I
G
V
S
A
N
SGKF
S
S
V
T
V
RSG
R
A
I
Q
A
------
K
A
A
I
L
A
C
G
T
F
L
N
G
-------
L
I
H
IGM
D
H
F
P
G
GRSTA
E
P
P
V
E
G
L
T
E
S
L
A
-
S
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
-
P
--------------------------------
F
S
F
S
S
T
S
V
A
N
R
N
L
-
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
--
I
L
R
T
G
F
D
R
S
---------
P
L
F
T
G
C
P
S
I
E
D
------
K
I
S
R
F
--------------------
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
-----
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
--------------
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
--------
G
V
L
I
D
D
L
I
T
K
E
T
KEPYRMFTSSAEHRLILRHDNA
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
E
S
I
I
K
R
V
------------------------------------------------
109
HHSearch
59.82
21%
-60
- C6 -
3CES
-
MNMG_ECOLI
A:
[5-471]
--
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
--
Q
-
Q
T
L
L
L
T
H
N
I
-------
D
----------------------
T
L
G
Q
M
S
C
N
P
A
----
I
G
G
I
----
G
K
G
H
L
V
K
E
V
----
D
A
L
-----
G
-----
G
L
-
M
A
K
A
I
D
---
Q
----------
A
-
G
--------
I
Q
F
R
I
L
NASKG
P
--
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
-----
Q
P
N
L
M
I
F
Q
Q
A
----------------------
V
E
D
L
I
V
E
NDRVV
G
A
V
T
QMG----
L
------------------
K
F
R
A
------
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
GSI
P
---------------------
L
S
R
R
L
R
-
E
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
-
M
P
V
--------------------------------
F
S
F
M
G
N
A
S
Q
H
P
Q
Q
-
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
--
S
N
L
D
R
S
---------------
P
S
I
E
D
------
K
V
M
R
F
--------------------
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
-----
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
--------------
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
--------
G
V
L
V
D
D
L
C
T
L
G
T
KEPYRMFTSRAEYRLMLREDNA
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
L
E
--------------------------------------------------
122
HHSearch
44.00
22%
-48
- C6 -
3E1T
1
?
A:
[6-235]
--
E
V
F
D
L
I
V
I
G
G
G
P
G
G
S
T
L
A
S
F
V
A
M
R
G
--
H
-
R
V
L
L
L
E
R
E
A
-------
F
P
R
-------
H
Q
------------
I
G
E
S
L
L
P
A
T
----
V
H
G
I
C
A
--
M
L
G
L
T
-
D
E
M
----
K
R
A
-----
G
FPIKR
G
G
-
T
F
R
W
G
K
EP
E
P
----------
W
-
T
F
G
FTR---
H
PDD-------
P
--
Y
--
G
F
A
Y
Q
V
E
R
A
R
F
D
D
M
L
L
R
N
S
E
R
-----
K
-
G
V
D
V
R
E
R
H
E---------------------
V
I
D
V
L
F
E
GERAV
G
V
R
Y
R
N
TEG
V
E
L
------------------
M
A
H
A
------
R
F
I
V
D
A
S
G
N
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Fugue
43.34
15%
-26
- C3 -
4J33
1
KMO_YEAST
A:
[22-411]
--
M
S
E
S
V
A
I
I
G
A
G
L
V
G
C
L
A
A
L
A
F
S
K
E
G
--
Y
-
N
V
T
L
Y
D
F
R
Q
-------
D
P
R
-------
L
D
-------------------
T
T
----
K
N
K
N
L
K
S
I
N
L
A
I
S
A
R
G
I
----
D
A
L
-----
K
-----
S
I
-
D
P
D
A
C
E
---
H
----------
I
-
L
--------
Q
----------
D
--
M
--
I
P
M
K
G
R
M
I
H
D
L
K
G
R
Q
E
S
Q
L
Y
G
-----
E
----------------------------------------------------------------------------------------
A
I
N
S
I
N
R
S
-------
V
---------------------
L
N
N
S
L
L
D
E
L
E
K
S
T
T
E
L
K
F
G
--
H
K
L
V
K
I
E
W
T
D
D
K
Q
I
C
H
F
A
I
G
T
-
P
-
H
--------------------------------
T
E
K
Y
D
F
V
I
G
-
C
D
--
G
A
Y
S
A
T
R
S
Q
M
Q
R
K
V
--
E
--
M
D
F
S
Q
E
---------
Y
M
N
L
R
Y
I
E
L
Y
I
P
P
T
E
E
F
K
P
N
Y
G
G
-------
N
F
A
I
---------
A
P
D
H
L
H
I
W
P
R
H
K
F
M
L
I
A
L
A
N
S
D
G
S
F
T
S
T
F
F
G
S
K
D
Q
I
S
D
L
I
T
S
K
S
R
V
R
E
F
-----
L
I
E
N
F
P
D
I
I
N
I
M
D
L
D
D
A
V
K
R
F
I
T
Y
P
K
E
S
L
----
V
C
--------------
V
N
C
K
P
Y
D
V
P
G
G
K
A
I
L
L
G
-
D
A
A
H
A
M
-----
V
P
F
Y
-
G
Q
G
M
N
--------
C
G
F
E
D
V
R
I
L
M
A
L
----------------------
L
K
K
H
S
G
-
D
R
S
R
A
F
T
E
Y
T
Q
-
T
R
H
K
D
L
V
S
I
T
E
L
A
K
R
N
Y
K
E
M
S
H
D
V
T
S
K
R
FLLRK-------------------------
124
HHSearch
40.94
21%
-49
- C6 -
3I3L
1
?
A:
[22-204]
--
T
R
S
K
V
A
I
I
G
G
G
P
A
G
S
V
A
G
L
T
L
H
K
L
G
--
H
-
D
V
T
I
Y
E
R
S
A
-------
F
P
R
-------
Y
------------
R
V
G
E
S
L
L
P
G
T
----
M
S
I
L
N
---
R
L
G
L
Q
-
E
K
I
----
D
A
Q
NYVKK
P
-----
S
A
-
T
F
L
W
G
Q
---
D
QA
P
W
T
F
S
FAA
P
A
P
--------
W
----------
V
--
F
--
D
H
A
V
Q
V
K
R
E
E
F
D
K
L
L
L
D
E
A
R
S
-----
R
-
G
I
T
V
H
E
E
T
P---------------------
V
TDVDLSDPD
R
V
V
L
T
V
R
R
GG
E
S
-
V
------------------
T
V
E
S
------
D
F
V
I
D
A
G
G
S
G
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
40.66
21%
-35
- C6 -
3NIX
1
?
A:
[4-171]
--
E
K
V
D
V
L
V
I
G
A
G
P
A
G
T
V
A
A
S
L
V
N
K
S
G
--
F
-
K
V
K
I
V
E
K
Q
K
-------
F
P
R
-------
F
------------
V
I
G
E
S
L
L
P
R
C
----
M
E
H
L
D
---
E
A
G
F
L
-
D
A
V
----
K
A
Q
GFQQK
F
-----
G
A
-
K
F
V
R
G
K
---
E
I
---------
A
-
D
F
N
FSDQFS
N
----------
G
--
W
--
N
W
T
W
Q
V
P
R
G
N
F
D
K
T
L
A
D
E
A
A
R
-----
Q
-
G
V
D
V
E
Y
E
V
G
---------------------
V
T
D
IKFFGT
D
S
V
T
T
I
E
D
ING
N
K
-
R
------------------
E
I
E
A
------
R
F
I
I
D
A
S
G
Y
G
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Fugue
40.58
12%
-24
- C3 -
3E1T
2
?
A:
[5-503]
-P
E
V
F
D
L
I
V
I
G
G
G
P
G
G
S
T
L
A
S
F
V
A
M
R
G
--
H
-
R
V
L
L
L
E
R
E
A
-------
F
P
R
H
Q
I
GESL
L
P
------
A
T
V
H
G
I
C
A
M
L
G
L
T
D
E
----
M
K
R
A
G
F
P
I
K
R
G
G
T
F
R
W
G
----
K
E
P
-----
E
-----
P
W
-
T
F
G
F
T
R
---
H
----------
P
-
D
--------
D
----------
P
--
Y
--
G
F
A
Y
Q
V
E
R
A
R
F
D
D
M
L
L
R
N
S
E
R
-----
K
G
V
D
V
R
E
R
H
E
----------------------
V
----------------------
I
------------------
D
V
L
F
E
GERAV
G
V
R
Y
R
N
T
E
G
V
E
L
M
-------
A
---------------------
H
A
R
F
I
V
D
A
S
G
N
R
T
R
V
---
S
Q
A
V
G
E
R
V
Y
S
R
F
F
Q
N
V
A
L
Y
G
Y
F
E
N
-
G
-
K
--------------------------------------
R
L
P
-
A
P
R
Q
G
N
I
L
S
A
A
F
Q
D
G
W
F
W
--
Y
--
I
P
L
S
D
T
---------
L
T
S
V
G
A
V
V
S
R
E
A
A
E
A
I
K
D
G
--
H
E
-------
A
A
L
L
R
Y
I
D
R
C
P
I
I
K
E
Y
L
A
P
A
T
R
V
T
T
G
D
Y
G
E
I
R
I
R
K
D
Y
S
Y
C
N
T
S
F
W
K
N
G
M
A
L
V
G
D
A
A
C
F
V
D
P
V
----------
F
S
S
G
V
H
L
A
T
Y
S
A
L
L
V
A
R
A
I
N
T
C
L
A
G
E
M
S
E
Q
--------------
R
C
F
E
E
F
E
R
R
Y
R
R
E
Y
G
N
F
Y
Q
F
L
V
A
F
Y
D
M
---
N
Q
D
-
T
D
S
Y
F
--------
W
S
A
R
K
I
I
N
T
E
E
R
----------------------
A
N
E
A
F
V
R
L
I
A
G
R
S
N
L
D
E
P
-
V
F
Q
S
N
F
M
Q
G
F
T
R
E
I
T
E
L
Q
H
L
A
M
F
G
L
V
P
S
RDGLAWA-----------------------
120
HHSearch
40.22
19%
-35
- C6 -
2QA2
1
?
A:
[11-167]
--
S
D
A
S
V
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
G
--
V
-
D
V
M
V
L
E
Q
L
P
-------
Q
R
T
-------
G
E
-----------
S
R
G
L
G
F
T
A
R
T
----
M
E
V
F
D
---
Q
R
G
I
L
-
P
A
F
----
G
P
V
-----
E
T
----
S
T
-
Q
G
H
F
G
G
---
R
----------
P
V
D
--------
F
GVL-------
E
G-
A
H-
Y
G
V
K
A
V
P
Q
S
T
T
E
S
V
L
E
E
W
A
L
G
-----
R
-
G
A
E
L
L
R
G
H
TVRALTDEGD
H
V
V
V
E
V
E
G
PD
G
-
P
----------------------
R
------------------
S
L
T
T
------
R
Y
V
V
G
C
D
G
G
R
S
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
40.05
21%
-28
- C6 -
3OZ2
8
GGR_THEAC
A:
[3-163]
--
E
T
Y
D
V
L
V
V
G
G
G
P
G
G
S
T
A
A
R
Y
A
A
K
Y
G
--
L
-
K
T
L
M
I
E
K
R
P
-------
E
I
G
-------
S
P
------
V
----
R
C
G
E
G
L
S
K
G
I
----
L
N
E
A
D
I
K
A
D
R
S
F
I
A
-------
N
E
V
-----
K
-----
G
A
-
R
I
Y
G
P
S
---
E
----------
K
-
R
PI
I
L
Q
S
EK
A
----------
G
--
N
--
E
V
G
Y
V
L
E
R
D
K
F
D
K
H
L
A
A
L
A
A
K
-----
A
-
G
A
D
V
W
V
K
S
PAL
G
V
I
K
E
NGKVA
G
A
K
I
R
H
NN
E
I
----------------------
V
------------------
D
V
R
A
------
K
M
V
I
A
A
D
G
F
E
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Fugue
39.47
13%
-24
* C3 *
3C96
1
?
A:
[4-403]
---
P
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
G
--
I
G
K
V
T
L
L
E
S
S
S
EIRPLG
V
G
I
N
-------
I
Q
------
P
A
A
V
E
A
L
A
E
L
G
L
G
P
A
----
L
A
A
T
A
I
P
T
H
E
L
R
Y
I
D
------
Q
S
G
-----
A
-----
T
V
-
W
S
E
P
R
G
---
V
----------
E
-
A
--------
G
----------
N
--
A
--
Y
P
Q
Y
S
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
R
E
-----
R
L
G
---------------------------------------------------------------------------------------
Q
Q
A
V
R
T
G
-------
L
---------------------
G
V
E
R
I
E
E
R
D
G
R
V
L
I
G
A
R
D
G
H
G
K
---
P
Q
A
L
G
A
D
V
L
V
G
------------------------------------------
A
D
G
I
H
S
A
V
R
-
A
H
L
H
P
D
Q
R
P
L
S
H
G
G
I
T
M
W
--
R
--
G
V
T
E
F
D
---------
R
F
L
D
G
K
T
M
I
V
A
N
D
E
H
W
S
R
L
V
A
Y
-----------
P
I
S
A
R
H
A
A
E
G
K
S
L
V
N
W
V
C
M
V
P
S
A
A
V
G
Q
L
D
N
E
A
D
W
N
R
D
---
G
R
L
E
D
V
L
P
F
F
A
D
W
D
-----------
L
G
W
F
D
I
R
D
L
L
T
R
N
Q
L
I
L
Q
Y
P
M
V
D
R
D
P
L
P
H
W
G
R
G
R
--------------
I
T
L
--------
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
-
G
I
E
L
A
--------
A
A
L
A
R
N
A
D
V
A
A
A
----------------------
L
R
E
Y
E
E
A
R
R
P
T
A
N
K
I
I
L
A
-
N
R
E
R
E
K
E
E
W
A
A
A
S
R
P
E
R
P
R
L
--------------------------------------
118
HHSearch
38.08
17%
-38
- C6 -
3ALJ
5
?
A:
[11-161]
---
T
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
G
--
W
-
D
V
R
L
H
E
K
S
S
-------
E
L
R
-------
A
F
-----------
G
A
G
I
Y
L
W
H
N
G
----
L
R
V
L
E
---
G
L
G
A
L
-
D
D
V
----
L
Q
G
S
H
T
P
-
P
-----
T
Y
E
T
W
M
H
N
K
---
S
----------
V
-
S
--------
K
E---------
T
FN
G
--
L
P
W
R
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
R
A
-----
L
-
G
V
D
I
S
V
N
S
EAVAADPV
G
R
L
T
L
QT-------
G
----------------------
E
------------------
V
L
E
A
------
D
L
I
V
G
A
D
G
V
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
36.85
15%
-51
- C6 -
3C4A
1
VIOD_CHRVO
A:
[1-150]
----
M
K
I
L
V
I
G
A
G
P
A
G
L
V
F
A
S
Q
L
K
Q
A
R
PL
W
-
A
I
D
I
V
E
K
N
D
-------
E
Q
E
-------
V
L
-----------
G
W
G
V
V
L
P
G
R
P
GQHP
A
N
P
L
S
Y
---
L
D
A
P
-
E
R
L
N
P
--
Q
F
L
-----
E
-----
D
F
-
K
L
V
H
H
N
---
E
----------
P
-
S
--------
L
MS--------
T
--
G
--
V
L
L
C
G
V
E
R
R
G
L
V
H
A
L
R
D
K
C
R
S
-----
Q
-
G
I
A
I
R
F
E
S
P
L
L
E
HGE---------------
L
----------------------
P
------------------
L
A
D
Y
------
D
L
V
V
L
A
N
G
V
N
H
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Fugue
35.34
10%
-20
- C3 -
3I3L
1
?
A:
[20-586]
HM
T
R
S
K
V
A
I
I
G
G
G
P
A
G
S
V
A
G
L
T
L
H
K
L
G
--
H
-
D
V
T
I
Y
E
R
S
A
-------
F
P
R
-------
Y
R
V
GESLL
P
G
T
M
S
I
L
N
R
L
G
L
Q
E
K
----
I
D
A
Q
N
Y
V
K
K
P
S
A
T
F
L
W
G
----
Q
D
Q
-----
A
-----
P
W
-
T
F
S
F
A
A
---
P
----------
A
-
P
--------
W
----------
V
--
F
--
D
H
A
V
Q
V
K
R
E
E
F
D
K
L
L
L
D
E
A
R
S
R
GI
T
V
H
E
E
T
P
V
T
D
V
D
----------------------
L
----------------------
S
------------------
D
P
D
R
------
V
V
L
T
V
R
R
G
G
E
S
V
T
-------
V
---------------------
E
S
D
F
V
I
D
A
G
G
S
G
G
P
I
S
R
K
L
G
V
---
R
Q
Y
D
E
F
Y
R
N
F
A
V
W
S
Y
F
K
L
-
K
-
D
PFEGDLKG
T
T
Y
S
I
T
F
ED
G
W
V
W
M
I
PIKDD
L
Y
S
V
G
L
V
V
D
R
S
K
S
-
A
E
V
R
E
Q
G
A
D
A
F
Y
S
S
T
L
A
K
--
C
--
A
K
A
M
D
I
L
GGAEQV
D
E
V
R
I
V
Q
D
W
S
Y
D
T
E
V
F
S
A
D
R
F
F
L
C
G
DAACFTD
P
L
F
S
Q
G
V
H
L
A
S
Q
S
A
V
S
A
A
A
A
I
D
R
I
T
R
H
G
D
E
K
D
A
V
H
A
W
Y
N
R
T
Y
R
E
A
Y
E
Q
Y
H
Q
F
L
A
S
F
Y
T
F
A
S
F
T
EPDS
E
F
W
R
K
R
R
I
T
E
S
D
D
D
R
L
T
R
K
K
W
F
E
S
F
R
D
R
A
S
T
M
I
A
I
G
RHQRPELSDDFSE
A
E
L
N
P
A
R
V
R
W
I
S
D
L
T
K
R
L
N
S
I
T
R
F
K
W
T
G
G
K
A
V
L
-
K
Q
H
Y
R
V
EPIGF
R
L
E
Q
R
E
V
L
A
N
G
E
G
L
----------------------
D
M
A
Q
Y
P
M
D
D
E
A
R
Q
I
F
Q
D
L
-
A
E
E
E
F
G
Y
K
T
L
V
K
R
L
G
A
V
G
R
Q
E
L
S
T
Q
I
V
V
R
L
M
E
A
GL
L
T
G
Y
D
AQG
E
K
V
F
V
Q
GRLHFGGVG
65
PsiBlast_CBE
33.88
39%
20
- C5 -
4J34
1
KMO_YEAST
B:
[2-44]
--
M
S
E
S
V
A
I
I
G
A
G
L
V
G
C
L
A
A
L
A
F
S
K
E
G
--
Y
-
N
V
T
L
Y
D
F
R
----------
Q
-------
D
P
------
R
L
D
T
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
33.60
39%
29
- C5 -
4J31
1
KMO_YEAST
B:
[23-69]
---
S
E
S
V
A
I
I
G
A
G
L
V
G
C
L
A
A
L
A
F
S
K
E
G
--
Y
-
N
V
T
L
Y
D
F
R
----------
Q
-------
D
P
------
R
L
D
T
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
33.53
14%
-25
- C6 -
3IHM
-
?
A:
[3-148]
----
K
R
I
G
I
V
G
A
G
T
A
G
L
H
L
G
L
F
L
R
Q
H
D
--
V
-
D
V
T
V
Y
T
D
R
K
-------
P
D
E
-------
Y
S
------
G
---
L
R
L
L
N
T
V
A
H
N
A
----
V
T
V
Q
R
---
E
V
A
L
D
V
N
E
W
PSEE
F
G
Y
-----
F
-----
G
H
-
Y
Y
Y
V
G
G
---
P
----------
Q
-
P
M
R
------
F
Y
G
--------
D
L
-
K
--
A
P
S
R
A
V
D
Y
R
L
Y
Q
P
M
L
M
R
A
L
E
A
-----
R
-
G
G
K
F
C
Y
D
A
----------------------
V
S
AED
L
E
G
---------------
L
------------------
S
E
Q
Y
------
D
L
L
V
V
C
T
G
K
Y
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------