@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1172: (2016-03-22 )
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKNHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPGETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIFNGDRD
Atome Classification :
(46 SA)
.........10........20........30-----.-.-...-----...40........50........60......---.----.70----..-------.-.-----------------------.-----....80-----------------------------------------.----------------------.---.-.-------------.-----------------------------------.--------------------------------------------------------------------------------------------------..90-------------.--.--.......100.....--..110.......120.......130.......140.......150.......160.......170.......180.......190.......---200--........210.......220.......230.......240.......250.--.....---------.--260-------......----.270.......280.......290.......300.....-..310.....-...320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKIFDYEDIQLI
P
N
K
CIVESRSECD
T
T
I
Q
FG-----P-
K
-
K
F
K-----LPVVP
A
N
M
Q
T
V
M
N
E
K
L
A
K
W
F
AEN
D
Y
F
Y
I
M
H
R---F----DE-----EA-------R-
I
-----------------------
P
-----
F
I
K
H
MQ-----------------------------------------N----------------------S---G-
L
-------------
F
-----------------------------------
A
--------------------------------------------------------------------------------------------------
S
I
S--------------V--G--VKK
A
E
F
D
F
I
E
K
L
A
Q
E--KLIP
E
Y
I
T
I
D
I
AHGH
S
D
S
V
I
N
M
I
K
H
I
K
N
HIPD
S
F
V
I
AGNVG
T
P
E
G
V
R
E
L
E
NAGADATKVGIGPG
R
V
C
I
T
K
IKTGFGTGG
W
Q
L
A
A
L
N
I
C
S
K
A
A---RK---
P
L
IADGGIR
T
H
G
D
I
A
K
S
I
RFG
A
S
M
V
M
I
G
S
L
F
A
AHEESPG
E
T
V
ELD
G
K
Q
Y
K
E
Y--FG
S
A
S
---------
E
--FQK-------GEHKNV----EG
K
K
M
F
V
E
HK
G
S
L
M
D
T
L
K
E
M
Q
Q
D
L
Q
S
S
ISYAGGK
D
L
K
S
L-
R
T
V
-
D
Y
V
I
V
R-NSIFNGDRD
1
PsiBlast_PDB
96.98
79%
-106
- C2 -
2A1Y
1
GUAC_BACAN
A:
[13-330]
--
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
T
V
T
L
G
-----
K
-
H
-
K
F
K
-----
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
---
F
----
Q
P
-----
E
K
-------
R
-
I
-----------------------
S
-----
F
I
R
D
M
Q
-----------------------------------------
S
----------------------
R
---
G
-
L
-------------
I
-----------------------------------
A
--------------------------------------------------------------------------------------------------
S
I
S
--------------
V
--
G
--
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
--
H
L
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
--
F
G
S
---------------------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
-
R
T
V
-
D
Y
V
V
V
K
-
N
S
I
F
-----
69
PsiBlast_CBE
72.79
35%
-81
- C2 -
4Q33
5
?
F:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
LGI
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK-------------------
K
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
23
PsiBlast_CBE
72.77
35%
-78
- C2 -
4QM1
3
?
B:
[35-357]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K-------------------
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
76
PsiBlast_CBE
72.74
35%
-80
- C2 -
4Q32
3
?
B:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
L
G
A
M
A
K
G--------------------
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
75
PsiBlast_CBE
72.73
35%
-84
- C2 -
4Q32
3
?
C:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK--------------------
F
V
P
---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
73
PsiBlast_CBE
72.57
35%
-84
- C2 -
4Q33
3
?
B:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMA---------------------
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
90
PsiBlast_CBE
72.52
36%
-78
- C2 -
3KHJ
2
?
C:
[11-328]
-
K
G
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
E
V
S
L
E
T
K
L
T
K
-----
N
-
V
-
S
L
K
-----
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N--
M
----
D
M
-----
E
S
-------
Q
-
V
-----------------------
N
-----
E
V
L
K
V
K
-----------------------------------------
N
----------------------
S
---
G
G
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
I
--
G
--
V
N
E
I
E
R
---
A
K
L
L
V
E
--
A
G
V
-
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
A
---
S
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
I
G
D
T
V
Y
K
Y
Y
R---------------------------------------
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
---------------------
72
PsiBlast_CBE
72.52
35%
-84
- C2 -
4Q33
3
?
C:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK--------------------
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
74
PsiBlast_CBE
72.41
35%
-83
- C2 -
4Q32
3
?
D:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
LGI
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMA----------------------
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
70
PsiBlast_CBE
72.35
35%
-81
- C2 -
4Q33
5
?
E:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMA---------------------
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
14
PsiBlast_PDB
72.26
35%
-88
- C2 -
4Q33
3
?
A:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK--------------------
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
28
PsiBlast_CBE
71.84
35%
-79
- C2 -
4MYX
2
?
D:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G-----------------
K
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
51
PsiBlast_CBE
71.81
33%
-75
- C2 -
2C6Q
2
GMPR2_HUMAN
G:
[20-347]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
S
F
S
-----
F
-
R
-
N
S
K
QTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H--
Y
----
S
L
-----
V
Q
-------
W
-
Q
-----------------------
E
-----
F
A
G
Q
N
P
-----------------------------------------
D
----------------------
C
---
L
-
E
-------------
H
-----------------------------------
L
--------------------------------------------------------------------------------------------------
A
A
S
--------------
S
--
G
--
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
--
I
P
Q
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
--
M
A
M
KKYA--------
S
----
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
----------
8
PsiBlast_PDB
71.27
33%
-71
- C2 -
2A7R
3
GMPR2_HUMAN
A:
[28-356]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
S
F
S
-----
F
-
R
-
N
S
K
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H--
Y
----
S
L
-----
V
Q
-------
W
-
Q
-----------------------
E
-----
F
A
G
Q
N
P
-----------------------------------------
D
----------------------
C
---
L
-
E
-------------
H
-----------------------------------
L
--------------------------------------------------------------------------------------------------
A
A
S
--------------
S
--
G
--
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
--
I
P
Q
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
--
M
A
M
K
K
YAGGV
A
E
Y
R
A
S
----
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
Q---------
71
PsiBlast_CBE
71.26
35%
-85
- C2 -
4Q33
4
?
D:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
-
N
E
V
S
L
K
T
Q
L
T
-----
K
-
K
I
Q
L
N
-----
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
E
V
-----------------------
D
-----
R
V
K
--
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
C
--------------------------------------------------------------------------------------------------
G
A
S
--------------
I
--
G
--
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
--
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
L
G
A
M
A
---------------------
F
V
P---
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
-
Y
E
N
-
A
N
F
V
V
Q
-
T
S
-------
9
PsiBlast_PDB
71.18
33%
-76
- C2 -
2BZN
1
GMPR2_HUMAN
A:
[20-346]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
S
F
S
-----
F
-
R
-
N
S
K
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H--
Y
----
S
L
-----
V
Q
-------
W
-
Q
-----------------------
E
-----
F
A
G
Q
N
P
-----------------------------------------
D
----------------------
C
---
L
-
E
-------------
H
-----------------------------------
L
--------------------------------------------------------------------------------------------------
A
A
S
--------------
S
--
G
--
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
--
I
P
Q
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
--
M
A
M
K
K
YA--------
S
----
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
-----------
6
PsiBlast_PDB
71.11
35%
-78
- C2 -
4MYX
6
?
A:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K-------------------
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
56
PsiBlast_CBE
71.02
33%
-74
- C2 -
2C6Q
3
GMPR2_HUMAN
B:
[20-347]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
S
F
S
-----
F
-
R
-
N
S
K
QTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H--
Y
----
S
L
-----
V
Q
-------
W
-
Q
-----------------------
E
-----
F
A
G
Q
N
P
-----------------------------------------
D
----------------------
C
---
L
-
E
-------------
H
-----------------------------------
L
--------------------------------------------------------------------------------------------------
A
A
S
--------------
S
--
G
--
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
--
I
P
Q
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
--
M
A
M
KKYAGGV
A
E
Y
R
A
S
----
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
----------
105
HHSearch
70.97
35%
-70
- C2 -
2C6Q
3
GMPR2_HUMAN
A:
[19-346]
--
S
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
S
F
S
F
RNSK
Q
-
T
-
Y
S
G
-----
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
---
H
----
Y
S
L
----
V
Q
-------
W
-
Q
-----------------------
E
-----
F
A
G
Q
N
P
-----------------------------------------
D
----------------------
C
---
L
-
E
-------------
H
-----------------------------------
L
--------------------------------------------------------------------------------------------------
A
A
S
--------------
S
--
G
--
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
I
P
Q
--
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
P
--
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
--
M
A
M
K
K
YAGGV
A
E
Y
R
A
S
----
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
-
S
R
R
T
T
F
I
R
V
-----------
22
PsiBlast_CBE
70.86
35%
-77
- C2 -
4QM1
3
?
C:
[35-358]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAM-----------------------
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
31
PsiBlast_CBE
70.83
35%
-75
- C2 -
4MYA
3
?
B:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K-------------------
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
21
PsiBlast_CBE
70.29
35%
-74
- C2 -
4QM1
3
?
D:
[35-356]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAME---------------------
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
40
PsiBlast_CBE
70.05
35%
-79
- C2 -
4MY8
5
?
C:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK-------------------
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
4
PsiBlast_PDB
69.67
35%
-75
- C2 -
4MYA
4
?
A:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K------------------
K
K
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
103
PsiBlast_CBE
69.57
31%
-76
- C2 -
4MZ1
7
?
C:
[9-350]
-
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
P
K
E
V
K
I
H
T
K
L
T
K
-----
N
-
I
-
T
L
N
-----
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N--
M
----
D
I
-----
A
S
-------
Q
-
V
-----------------------
R
-----
E
V
K
R
V
K
-----------------------------------------
K
----------------------
S
ESG
G
-
I
KKRKEYPDANKDN
F
-----------------------------------
G
--------------------------------------------------------------------------------------------------
R
L
R
--------------
V
--
G
AA
I
G
V
G
Q
M
D
R
V
D
A
L
V
E
A
--
G
V
--
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
--
P
Q
I
S
A
I
D
E
C
V
E
E
A
---
N
K
FGV
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
RG
M
G
S
L
G
---------
A
--
M
Q
K
-------------LVP-
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
-
Q
-------------------
7
PsiBlast_PDB
69.26
35%
-74
- C2 -
4QM1
3
?
A:
[35-358]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K---------------------
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
102
PsiBlast_CBE
69.08
31%
-74
- C2 -
4R7J
8
?
A:
[9-350]
-
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
P
K
E
V
K
I
H
T
K
L
T
K
-----
N
-
I
-
T
L
N
-----
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N--
M
----
D
I
-----
A
S
-------
Q
-
V
-----------------------
R
-----
E
V
K
R
V
K
-----------------------------------------
K
----------------------
S
E-----KKRKEYPD
A
N
K
D
N
F
-----------------------------------
G
--------------------------------------------------------------------------------------------------
R
L
R
--------------
V
--
G
A
A
I
G
V
G
Q
M
D
R
V
D
A
L
V
E
A
--
G
V
--
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
--
P
Q
I
S
A
I
D
E
C
V
E
E
A
---
N
K
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
---------
A
--
M
Q
K
-------------LVP-
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
-
Q
-------------------
41
PsiBlast_CBE
68.79
35%
-76
- C2 -
4MY8
7
?
B:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK--------------------
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
104
PsiBlast_CBE
68.52
31%
-74
- C2 -
4MZ1
7
?
B:
[9-350]
-
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
P
K
E
V
K
I
H
T
K
L
T
K
-----
N
-
I
-
T
L
N
-----
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N--
M
----
D
I
-----
A
S
-------
Q
-
V
-----------------------
R
-----
E
V
K
R
V
K
-----------------------------------------
K
----------------------
S
------KEYPDANKDN---
F
-----------------------------------
G
--------------------------------------------------------------------------------------------------
R
L
R
--------------
V
--
G
AA
I
G
V
G
Q
M
D
R
V
D
A
L
V
E
A
--
G
V
--
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
--
P
Q
I
S
A
I
D
E
C
V
E
E
A
---
N
K
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
RG
M
G
S
L
G
---------
A
--
M
Q
K
-------------LVP-
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
-
Q
-------------------
111
HHSearch
67.95
34%
-88
- C2 -
3USB
4
?
A:
[33-493]
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
-----
E
S
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
---
N
----
M
S
I
----
E
Q
Q
A
E
Q
V
D
K
V
-
K
R
SESGVIS
D
P
F
F
L
T
PEHQV
Y
D
A
E
H
-----
L
M
G
K
Y
R
-----------------------------------------
I
----------------------
S
---
G
-
V
-------------
P
-----------------------------------
V
V
NNLDERKLV
G
I
I
T
N
R
D
M
R
F
IQDYSIKISDVMTK
E
Q
L
I
T
A
P
VGTT
L
S
E
A
E
K
I
L
Q
K
YKIE
K
L
P
L
V
D
NNGVLQ
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PN
S
A
K
D
KQG
R
L
L
V
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
--
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
----------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
A
Q
F
I
R
M
S
-
G
A
G
L
L
----
2
PsiBlast_PDB
67.87
35%
-74
- C2 -
4MY8
9
?
A:
[35-352]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-----
S
-
L
-
Q
L
N
-----
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
NMS
I
----
E
Q
-----
Q
A
-------
E
-------------------------
Q
-----
V
D
K
V
K
R
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G
SK-----------------
L
V
P---
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
114
HHSearch
67.47
33%
-73
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[10-476]
-
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
-
P
N
E
V
D
L
K
T
K
L
A
-----
D
N
L
-
T
L
N
-----
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
---
N
----
M
S
I
----
T
E
Q
A
E
E
V
R
K
V
-
K
R
SENGVIID
P
F
F
L
T
PEHK
V
S
E
A
E
E
-----
L
M
Q
R
Y
R
IS
G
V
P
I
V
ETLANRKLV
G
I
I
T
N
R
D
M
R
F
ISDYNAPISEHMTSE
H
L
V
T
A
A
VGTD
L
E
T
A
E
R
I
L
H
E
H
RI
E
---
K
-
L
-------------
P
L
V
D
NSGRLS
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PHAAKDEFG
R
L
L
V
--------------------------------------------------------------------------------------------------
A
A
A
--------------
V
--
G
--
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
--
G
--
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
---
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
--
R
G
M
G
S
---------
I
AA
M
K
K
--------
N
K
L
V
P
----
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
-
H
E
N
A
Q
F
V
E
M
S
-
G
A
G
L
I
E
S
H
-
97
PsiBlast_CBE
66.19
32%
-79
* C2 *
4IX2
2
?
D:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MSIE
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
RG
M
--------------------------------P---
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
98
PsiBlast_CBE
64.40
32%
-77
- C2 -
4IX2
2
?
C:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MSIE
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
RG
M
--------------------------------P---
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
100
PsiBlast_CBE
63.96
32%
-76
- C2 -
4IX2
2
?
A:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------P---
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
99
PsiBlast_CBE
63.95
32%
-73
- C2 -
4IX2
2
?
B:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------P---
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
92
PsiBlast_CBE
63.90
32%
-74
- C2 -
4X3Z
3
?
B:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
S
--------------KLVP
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
94
PsiBlast_CBE
63.08
32%
-81
- C2 -
4QQ3
3
?
A:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
----------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
101
PsiBlast_CBE
62.84
32%
-71
- C2 -
4FO4
3
?
B:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MSIE
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
RG
M
G
S
L
G
---------
A
--
M
S
--------------KLVP
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
96
PsiBlast_CBE
62.33
32%
-70
- C2 -
4QNE
3
?
A:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
S
--------------LVP-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
93
PsiBlast_CBE
62.10
32%
-74
- C2 -
4X3Z
3
?
A:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
S
--------------LVP-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
95
PsiBlast_CBE
61.42
32%
-67
- C2 -
4QNE
3
?
B:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MSIE
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
RG
M
G
S
L
G
---------
A
--
M
S
--------------LVP-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
116
HHSearch
61.22
30%
-70
- C2 -
2CU0
1
IMDH_PYRHO
A:
[13-468]
-
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
-
P
K
D
V
D
V
S
T
R
I
T
P----
N
-
V
-
K
L
N
-----
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
---
N
----
M
G
I
E
E
Q
V
E
Q
-------
V
-
K
-----------------------
R
V
K
R
AE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYKN
A
V
R
D
ENG
E
L
L
V
A
A
A
--
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
--
G
--
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
D
-
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
--
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
G
L
---
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
--
R
G
M
G
S
---------
L
G
A
M
M
K
YMK----
T
R
K
F
V
P
----
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
-
K
E
K
G
E
F
V
I
I
T
-
H
A
G
I
K
E
S
H
-
20
PsiBlast_PDB
60.83
32%
-73
- C2 -
4FO4
3
?
A:
[14-334]
---
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
T
R
L
T
K
-----
N
-
I
-
A
L
N
-----
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
-
V
-----------------------
H
-----
Q
V
K
--
I
-----------------------------------------
S
----------------------
G
---
G
-
L
-------------
R
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
S
--------------KLVP
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
------------------
16
PsiBlast_PDB
56.80
40%
-86
- C2 -
3TSD
1
?
A:
[245-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
--
R
G
--------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------
77
PsiBlast_CBE
55.65
40%
-85
- C2 -
3TSD
1
?
B:
[245-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------
L
-----------------------------------
V
--------------------------------------------------------------------------------------------------
G
A
A
--------------
V
--
G
--
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
-----
G
R
Q
F
K
V
Y
--
R
G
M
------------------------------------
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
-------------------