@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0435: (2015-12-15 )
MYKVADIFCGAGGLSYGFSTHPYFELIWANDIDKDAILSYQANHKETQTILCDIAQLHCHNLPRVPIDILLGGPPCQSYSTLGKRKMDEKANLFKEYLRILDLVKPKIFVFENVVGLMSMQKGQLFQRICNAFKERGYILEHAILNALDYGVPQVRERVILVGALKSFKQKFYFPKPIKTHFSLKDALGDLPPIQSGENGDALGYLKNADNVFLEFVRNSKELSEHSSPKNNEKLIKIMQTLKDGQSKDDLPESLRPKSGYINTYAKMWWEKPAPTITRNFSTPSSSRCIHPRDSRALSIREGARLQSFPDNYKFYGSANAKRLQIGNAVPPLLSAALAHAVFDFLRGKNV
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20...-.....30........40........50........60-----------.-.-----.-----...-------------...70........80.----.----.-.-.------...-90.-.......100.......110.......120.......130.......140........150.......160..-----------------.....------170----.--.----.-------------------------..-----------------------..------------------------------180----------.........190.....---..200.....---..------210.......220-.---.------.-......230----------.........------------------240------------------------------------------------.-...--.--....--------------------------------------------250----------.--------------...------------...-------------------------------------------------.--.260-------------.........270.......280-.----.--.-.----------...--290...--------------------....300.......310...-..-..320.......330.......340---.......350--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
Y
K
V
A
D
I
F
CGAGGLSYGFSTH
P
Y
F
-
E
L
I
WANDI
D
K
D
A
I
L
S
YQANH
K
E
T
Q
T
I
L
C
D
I
A
Q
L
H
CH------------N-L-----P-----RV
P
-------------
I
D
I
L
LGGPPC
Q
S
Y
S
T
L
----
G
----K-R-
K
------
M
D
E
-
K
A
N
-
L
F
K
E
Y
L
R
I
L
D
LVKP
K
I
F
V
F
E
N
V
V
G
L
M
S
M
Q
K
G
Q
L
F
Q
R
I
C
N
A
F
K
ER
G
Y
I
L
E
-
H
A
I
L
N
A
L
DYG
V
P
Q
V
R
E
R
V
I
L
V
G
A
-----------------
L
K
S
F
K
------
Q
KF----Y--F----P-------------------------K
P
-----------------------
I
K
------------------------------
T
------------
H
F
S
L
K
D
A
LGDLPPIQSG---ENGDALGYLK---N
A
------
D
N
V
F
L
E
F
V
RN
S
---
K
---
E
------
L
-
S
EHSSPK------------
N
N
E
K
L
I
K
I
M
------------------
Q
--------------------------------------------------
T
-
L
KD--G--QSKD--------------------------------------------D------------L--------------
P
E
S------------LRP-------------------------------------------------K--SG---------------
Y
I
N
T
Y
A
K
M
W
WEKPA
P
T
I
T
RNFS-T----P--S-S----------SRC--IHPRDS--------------------
R
A
L
S
IREGARLQSFPDN
Y
K
F
-YG-SAN
A
K
R
L
QIGNAV
P
P
L
L
S
A
A
L
A
H
A
V
---
F
D
F
L
RGKNV---------
21
HHSearch
91.64
28%
-72
* C4 *
3SWR
24
DNMT1_HUMAN
A:
[540-1001]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
T
L
D
V
F
S
G
C
G
G
L
S
E
G
F
H
Q
-
A
G
I
S
D
T
L
W
A
I
E
M
W
D
P
A
A
Q
A
F
R
L
N
N
P
G
S
T
V
F
T
E
D
C
N
I
L
L
K
L
V
M
A
GETTNSRG
Q
R
L
P
-----
Q
-----
K
G
D
-------------
V
E
M
L
C
G
G
P
P
C
Q
G
F
S
G
M
----
N
----
R
-
F
N
S
R
T
Y
---
S
K
F
-
K
N
S
-
L
V
V
S
F
L
S
Y
C
D
Y
Y
R
P
R
F
F
L
L
E
N
V
R
N
F
V
S
F
K
R
S
M
V
L
K
L
T
L
R
C
L
V
R
M
G
Y
Q
C
T
-
F
G
V
L
Q
A
G
Q
Y
G
V
A
Q
T
R
R
R
A
I
I
L
A
A
-----------------
A
P
---------
G
E
K
L
P
--
L
--
F
----
P
-------------------------
E
P
-----------------------
L
H
VFAPRACQL
S
V
V
V
DD
K
K
F
V
S
NITRLSSGPF
R
------------
T
I
T
V
R
D
T
M
S
D
L
P
E
V
R
N
G
---
A
S
A
L
E
I
S
Y
N
G
---
E
P
------
Q
S
W
F
Q
R
Q
L
R
G
A
---
Q
YQ
P
I
------
L
-
R
D
H
I
C
K
D
------------
M
S
A
L
V
A
A
R
M
------------------
R
--------------------------------------------------
H
-
I
P
L
AP
G
--
S
D
W
R
--------------------------------------------
D
------------
L
--------------
P
N
I
E
V
R
L
SDG
T
M
A
R
K
L
R
Y
THHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIP
W
C
L
P
H
TGNR
H
--
N
H
---------------
W
A
G
L
Y
G
R
L
E
W
D
G
F
F
S
T
T
V
T
N
P
E
-
P
----
M
--
G
K
Q
----------
G
R
V
--
L
H
P
E
Q
H
--------------------
R
V
V
S
V
R
E
C
A
R
S
Q
G
F
P
D
T
Y
R
L
-
F
G
-
N
I
L
D
K
H
R
Q
V
G
N
A
V
P
P
P
L
A
K
A
I
G
L
E
I
---
K
L
C
M
L
A
K
A
----------
50
Fugue
90.95
27%
-70
- C4 -
3AV4
4
DNMT1_MOUSE
A:
[67-1322]
PKCPECGQHLDDPN
L
K
Y
Q
Q
H
P
EDAVD
E
P
Q
M
L
T
SEKLSYED
S
P
M
H
R
F
T
S
F
S
V
Y
C
SRGHLCPVDTGLIEKN
V
E
L
Y
F
S
G
C
A
K
A
IHDENPSMEG
G
I
N
G
K
NLGPIN
Q
W
W
L
S
GFDGGEKV
L
I
G
F
S
T
AFA
E
Y
I
L
M
E
PSKEY
E
P
I
F
G
L
M
Q
E
K
I
Y
I
S
K
I
V
V
E
F
L
Q
N
N
PDAV
Y
E
D
L
I
N
K
I
E
T
T
V
P
P
STINVNRFT
E
D
S
L
L
R
H
A
Q
F
V
V
S
Q
V
E
S
Y
D
E
A
KDDDETPIFLS
P
C
M
R
A
L
I
H
L
A
GVSLGQ
R
R
A
T
RAPTKATTT
K
L
V
Y
Q
I
F
D
T
F
F
S
E
QIEKRRRCGVCEVCQQPACLKRRC
P
N
L
A
V
K
E
A
D
D
D
E
EADDEMPS
P
K
K
L
HQ
G
K
K
K
K
Q
N
KD
R
I
S
W
L
G
QPMKIER
T
Y
Y
Q
K
V
S
I
DE
E
M
L
E
VG
D
C
V
S
V
I
P
DDSSK
P
L
Y
L
A
R
VT
A
L
W
E
D
KNG
Q
M
M
F
H
A
H
W
F
C
A
GTDTVLGATSDPL
E
L
F
L
V
G
E
C
E
N
M
Q
LSYIH
S
K
V
K
V
I
Y
KAPSENWAMEGGK
T
Y
F
F
Q
LWYNQEYARFESPPK
T
Q
P
T
EDNKHKFC
L
S
C
I
R
L
A
E
L
R
Q
K
E
MPKVLEQIEEVDG
R
V
Y
C
SSITKNG
V
V
Y
R
L
G
D
S
V
Y
L
P
PEAFTFNIKVK
K
D
P
V
NETLYPEHYRKYSL
D
A
P
E
P
Y
R
I
G
R
I
KEI
H
C
G
K
K
KGKVNEAD
I
K
L
R
L
Y
K
F
Y
R
PENTHR
S
Y
N
G
S
Y
HTDIN
M
L
Y
W
S
D
E
E
A
V
V
N
FSDVQ
G
R
C
T
V
E
Y
GEDLLES
I
Q
D
Y
S
Q
GGPD
R
F
Y
F
L
E
A
Y
N
SKTKNFEDPPNHARSKLP
K
L
R
T
L
D
V
F
S
G
C
G
G
L
S
E
G
F
H
Q
A
G
I
S
-
E
T
L
W
A
I
E
M
W
D
P
A
A
Q
A
F
R
L
N
N
P
G
T
T
V
F
T
E
D
C
N
V
L
L
K
L
------------
V
-
M
-----
A
-----
G
E
V
TNSLGQ
R
L
P
Q
KGD
V
E
M
L
C
G
G
P
P
C
Q
G
F
S
G
M
NRFN
S
----
R
-
T
-
Y
------
S
K
F
-
K
N
S
-
L
V
V
S
F
L
S
Y
C
D
Y
Y
R
P
R
F
F
L
L
E
N
V
R
N
F
V
S
Y
R
R
S
M
V
L
K
L
T
L
R
C
L
V
R
M
G
Y
Q
C
T
-
F
G
V
L
Q
A
G
Q
Y
G
V
A
Q
T
R
R
R
A
I
I
L
A
A
-----------------
A
P
G
E
K
L
P
L
F
P
E
P
L
H
----
V
--
F
----
A
-------------------------
P
R
ACQL
S
V
V
V
DD
K
K
F
V
S
NITRLSSG
P
F
------------------------------
R
------------
T
I
T
V
R
D
T
M
S
D
L
P
E
I
Q
N
G
---
A
S
N
S
E
I
P
Y
N
G
---
E
P
------
L
S
W
F
Q
R
Q
L
R
G
S
---
H
Y
Q
P
I
------
L
-
R
D
H
I
C
K
D
------------
M
S
P
L
V
A
A
R
M
------------------
R
H
IPLFPGSDWRDLPNIQVRLGDG
V
I
A
H
K
L
Q
Y
T
F
HDVKNGYSSTGALRGVC
S
-
C
A
E
--
G
--
K
A
C
D
--------------------------------------------
P
ESRQFSTLIP
W
C
L
--------------
P
H
T
------------
G
N
R
-------------------------------------------------
H
--
N
H
---------------
W
A
G
L
Y
G
R
L
E
W
D
G
F
F
S
T
T
V
T
N
P
E
P
M
----
G
--
K
-
Q
----------
G
R
V
--
L
H
P
E
Q
H
--------------------
R
V
V
S
V
R
E
C
A
R
S
Q
G
F
P
D
S
Y
R
F
-
F
G
-
N
I
L
D
R
H
R
Q
V
G
N
A
V
P
P
P
L
A
K
A
I
G
L
E
I
---
K
L
C
L
L
S
S
A
R
E
S
A
S
A
A
V
K
A
49
Fugue
90.43
27%
-75
- C4 -
3PT9
3
DNMT1_MOUSE
A:
[1-871]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKDR
I
S
W
L
G
QPMKIEEN
R
T
Y
Y
Q
K
V
S
I
DE
E
M
L
E
VG
D
C
V
S
V
I
P
DDSSK
P
L
Y
L
A
R
VT
A
L
W
E
D
KNG
Q
M
M
F
H
A
H
W
F
C
A
GTDTVLGATSDPL
E
L
F
L
V
G
E
C
E
N
M
Q
LSYIH
S
K
V
K
V
I
YKAPSENWAMEGK
T
Y
F
F
Q
L
WYNQEYA
R
F
E
S
P
PK
T
Q
P
T
EDNKHKFC
L
S
C
I
R
L
A
E
L
R
Q
K
E
M
P
K
V
LEQIEEVDG
R
V
Y
C
S
S
I
T
K
NG
V
V
Y
R
LG
D
S
V
Y
L
P
PEAFTFN
I
K
V
A
SPVKRPK
K
D
P
V
N
ETLYPEHYRKYSLDAPE
P
Y
R
I
G
R
IK
E
I
H
C
G
K
K
KGKVNEA
D
I
K
L
R
L
Y
K
F
Y
R
PENTHRSYNGSYHTDIN
M
L
Y
W
S
D
E
E
A
V
V
N
FSDVQ
G
R
C
T
V
E
Y
GEDLLES
I
Q
D
Y
S
Q
GGPD
R
F
Y
F
L
E
A
Y
N
SKTKNFEDPPNHARSPGI
K
L
P
K
L
R
T
L
D
V
F
S
G
C
G
G
L
S
E
G
F
H
Q
A
G
I
S
-
E
T
L
W
A
I
E
M
W
D
P
A
A
Q
A
F
R
L
N
N
P
G
T
T
V
F
T
E
D
C
N
V
L
L
K
L
------------
V
-
M
-----
A
-----
G
E
V
TNSLG
Q
R
L
P
Q
KGD
V
E
M
L
C
G
G
P
P
C
Q
G
F
S
G
M
----
N
RFN
S
R
-
T
-
Y
------
S
K
F
-
K
N
S
-
L
V
V
S
F
L
S
Y
C
D
Y
Y
R
P
R
F
F
L
L
E
N
V
R
N
F
V
S
Y
R
R
S
M
V
L
K
L
T
L
R
C
L
V
R
M
G
Y
Q
C
T
-
F
G
V
L
Q
A
G
Q
Y
G
V
A
Q
T
R
R
R
A
I
I
L
A
A
A
PGEKLPLFPEPLHVFA
P
R
A
C
Q
------
L
S
V
----
V
--
V
----
D
-------------------------
D
K
-----------------------
K
F
------------------------------
V
S
NITRLSSGPFR
T
I
T
V
R
D
T
M
S
D
L
P
E
I
Q
N
G
---
A
S
N
S
E
I
P
Y
N
G
---
E
P
------
L
S
W
F
Q
R
Q
L
R
G
S
HYQ
P
---
I
------
L
-
R
D
H
I
C
K
D
------------
M
S
P
L
V
A
A
R
M
R
H
IPLFPGSDWRDLPNIQ
V
--------------------------------------------------
R
-
L
G
D
--
G
--
V
I
A
H
K
L
Q
Y
TFHDVKNGYSSTGALRGVCSCAEGKACDPESRQFSTLIP
W
C
------------
L
--------------
P
H
T
------------
G
N
R
-------------------------------------------------
H
--
N
H
---------------
W
A
G
L
Y
G
R
L
E
W
D
G
F
F
S
T
T
V
T
N
P
E
P
M
----
G
--
K
-
Q
----------
G
R
V
--
L
H
P
E
Q
H
--------------------
R
V
V
S
V
R
E
C
A
R
S
Q
G
F
P
D
S
Y
R
F
-
F
G
-
N
I
L
D
R
H
R
Q
V
G
N
A
V
P
P
P
L
A
K
A
I
G
L
E
I
---
K
L
C
L
L
S
------------
23
HHSearch
83.95
32%
-68
- C4 -
3UBT
8
MTH3_HAEAE
Y:
[1-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
L
I
S
L
F
S
G
A
G
G
L
D
L
G
F
Q
K
-
A
G
F
-
R
I
I
C
A
N
E
Y
D
K
S
I
W
K
T
Y
E
S
N
H
S
A
K
-
L
I
K
G
D
I
S
K
I
S
S
D
------------
E
-------------
F
P
K
-------------
C
D
G
I
I
G
G
P
P
S
Q
S
W
S
E
G
----
G
----
S
-
L
R
G
I-----
D
D
P
-
R
G
K
-
L
F
Y
E
Y
I
R
I
L
K
Q
K
K
P
I
F
F
L
A
E
N
V
K
G
M
M
A
Q
R
H
N
K
A
V
Q
E
F
I
Q
E
F
D
N
A
G
Y
D
V
H
-
I
I
L
L
N
A
N
D
Y
G
V
A
Q
D
R
K
R
V
F
Y
I
G
F
-----------------
R
K
---------
E
L
N
I---
N
YL
P
----
P
-------------------------
I
P
-----------------------
H
L
------------------------------
I
------------
K
P
T
F
K
D
V
I
W
D
L
K
D
N
P
I
P
---
A
L
D
---------------------
K
--
N
K
T
N
G
---
N
KC-
I
------
Y
-
P
N
H
E
Y
---------------------
F
-----------------------------------------------------------------------------
I
--
G
S
Y
--------------------------------------------------------------------------------------------------------------------------------------------
S
--
T
I
---------------
F
M
S
R
N
R
V
R
Q
W
N
E
P
A
F
T
V
Q
A
S
G
R
-
Q
CQLH
P
--
Q
-
A
PVMLKVSKNL
N
K
F
VE
G
K
E
H
L
Y
--------------------
R
R
L
T
V
R
E
C
A
R
V
Q
G
F
P
D
D
F
I
F
-
H
Y
E
S
L
N
D
G
Y
K
M
I
G
N
A
V
P
V
N
L
A
Y
E
I
A
K
T
I
---
K
S
A
L
E
I
C
K
----------
3
PsiBlast_PDB
83.72
27%
-74
- C4 -
4FT4
1
CMT1_MAIZE
B:
[380-737]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
V
I
C
G
G
P
P
C
Q
G
I
S
G
F
----
N
----
R
-
Y
-
R
NRDEPL
K
D
E
-
K
N
K
-
Q
M
V
T
F
M
D
I
V
A
Y
L
K
P
K
Y
V
L
M
E
N
V
V
D
I
L
K
F
A
D
G
Y
L
G
K
Y
A
L
S
C
L
V
A
M
K
Y
Q
A
R
-
L
G
M
M
V
A
G
C
Y
G
L
P
Q
F
R
M
R
V
F
L
W
G
A
-----------------
L
S
S
M
V
L
-----
P
K
Y
----
P
--
L
----
P
TYD
V
V
V
R
GGAPNAFSQCMVAYDETQ
K
P
S----------------------
L
K
------------------------------
K
------------
A
L
L
L
G
D
A
I
S
D
L
P
K
V
Q
N
H
---
Q
P
N
D
V
M
E
Y
G
G
---
S
P
------
K
T
E
F
Q
R
Y
I
R
L
S
---
R
---
K
DMLDWS
F
-
G
E
G
A
G
P
D
EGKLLDHQPLRL
N
N
D
D
Y
E
R
V
Q
------------------
Q
--------------------------------------------------
I
P
V
K
K
--
G
--
A
N
F
R
--------------------------------------------
D
------------
L
KG
V
R
V
G
ANN
I
V
E
W
D
P
E
I
------------
E
R
V
-------------------------------------------------
K
L
S
S
G
KPLVP
D
Y
A
M
S
FIKGK
S
L
K
P
F
G
R
L
W
W
D
E
T
V
P
T
V
V
T
R
-
A
-
E
----
P
--
H
-
N
----------
Q
V
I
--
I
H
P
T
Q
A
--------------------
R
V
L
T
I
R
E
N
A
R
L
Q
G
F
P
D
Y
Y
R
L
-
F
G
-
P
I
K
E
K
Y
I
Q
V
G
N
A
V
A
V
P
V
A
R
A
L
G
Y
C
L
---
G
Q
A
Y
L
G
E
S
E
---------
1
PsiBlast_PDB
82.78
29%
-75
- C4 -
3UBT
8
MTH3_HAEAE
Y:
[6-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
S
G
A
G
G
L
D
L
G
F
Q
K
A
G
-
F
-
R
I
I
C
A
N
E
Y
D
K
S
I
W
K
T
Y
E
S
N
H
-
S
A
K
L
I
K
G
D
I
S
K
I
S
S
D
------------
E
-
F
-----
P
-----
K
C
---------------
D
G
I
I
G
G
P
P
S
Q
S
W
S
E
G
----
G
----
S
L
R
-
G
------
I
D
D
P
R
G
K
-
L
F
Y
E
Y
I
R
I
L
K
Q
K
K
P
I
F
F
L
A
E
N
V
K
G
M
M
A
Q
R
H
N
K
A
V
Q
E
F
I
Q
E
F
D
N
A
G
Y
D
V
H
-
I
I
L
L
N
A
N
D
Y
G
V
A
Q
D
R
K
R
V
F
Y
I
G
F
-----------------
R
K
E
L
N
------
I
N
Y
----
L
--
P
----
P
-------------------------
I
P
-----------------------
H
L
------------------------------
I
------------
K
P
T
F
K
D
V
I
W
D
L
-----------------------
K
------
D
N
P
I
P
A
L
D
K
N
K
---
T
---
N
------
G
-
N
K
C
I
Y
P
-------------
N
H
E
Y
F
I
G
S
Y
------------------
S
--------------------------------------------------
T
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
M
S
R
N
R
V
R
Q
W
N
E
P
A
F
T
V
------
Q
----
A
--
S
-
G
----------
R
Q
C
Q-
L
H
P
Q
A
P
VMLKVSKNLNKFVEGKEHLY
R
R
L
T
V
R
E
C
A
R
V
Q
G
F
P
D
D
F
I
F
H
Y
E
-
S
L
N
D
G
Y
K
M
I
G
N
A
V
P
V
N
L
A
Y
E
I
A
K
T
I
KSA
L
E
I
C
K
-------------
25
HHSearch
82.74
26%
-60
- C4 -
3G7U
3
?
A:
[2-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
V
I
D
L
F
S
G
V
G
G
L
S
L
G
A
A
R
-
A
G
F
-
D
V
K
M
A
V
E
I
D
Q
H
A
I
N
T
H
A
I
N
F
P
R
S
L
H
V
Q
E
D
V
S
L
L
N
A
E
------------
I
-
I
K
G
F
F
K
N
-----
D
M
P
-------------
I
D
G
I
I
G
G
P
P
C
Q
G
F
S
----------------------
D
D
S
-
R
N
Q
-
L
Y
M
H
F
Y
R
L
V
S
E
L
Q
P
L
F
F
L
A
E
N
V
P
G
I
M
Q
E
K
Y
S
-
G
I
R
N
K
A
F
N
L
V
S
G
D
Y
D
I
L
D
P
I
K
V
K
A
S
D
Y
G
A
P
T
I
R
T
R
Y
F
F
I
G
V
-----------------
K
K
---------
S
L
K
L
---
D
--
I
S
DEV
F
-------------------------
M
P
K----------------------
M
I
------------------------------
D
------------
P
V
T
V
K
D
A
L
Y
G
L
P
D
I
I
D
A
---
N
W
Q
S
D
S
E
S
W
R
T
I
K
K
D
RK----
G
G
F
Y
E
K
L
W
G
Q
I
---
P
---
R
------
N
V
G
D
T
E
-------------------
S
I
A
K
L
------------------
K
N
-------------------------------------------------
N
-
I
I
S
--
G
C
T
G
T
L
H
--------------------------------------------
S
K
I
V
Q
E
-------
R
--------------
Y
A
S
------------
L
S
F
G------------------------------------------------
E
--
T
D
---------------
K
I
S
R
S
T
R
L
D
P
N
G
F
C
P
T
L
---------------------------
V
R
P
--
I
H
P
Y
H
P
--------------------
R
V
I
T
P
R
E
A
A
R
L
Q
G
F
P
D
W
F
R
F
-
H
V
-
T
K
W
H
S
F
R
Q
I
G
N
S
V
S
P
I
V
A
E
Y
I
L
K
G
L
---
Y
N
L
L
N
E
------------
22
HHSearch
82.22
28%
-72
- C4 -
2C7P
10
MTH1_HAEPH
A:
[11-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
-
C
G
A
-
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
--
K
P
E
G
D
I
T
Q
V
N
E
K
------------
T
-------------
I
P
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
K
G
F-----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
---------
D
L
N
IQ
N
F
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
----------------------------------------------
E
L
N
T
F
V
K
D
L
L
L
P
D
S
E
---
V
E
H
----
L
---------------
V
I
D
---
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
-
V
R
L
------------------
G
--------------------------------------------------
I
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
---------------
G
G
Q
G
E
R
I
Y
S
T
R
G
I
A
I
T
L
S
A
Y
G
G
-
G
----
I
FA
K
-
T
----------
G
G
Y
--
L
V
N
G
K
T
--------------------
R
K
L
H
P
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
2
PsiBlast_PDB
81.74
27%
-61
- C4 -
3G7U
3
?
A:
[5-367]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
L
F
S
G
V
G
G
L
S
L
G
-
A
A
R
A
G
F
-
D
V
K
M
A
V
E
I
D
Q
H
A
I
N
T
H
A
I
N
F
P
R
S
L
H
V
Q
E
D
V
S
L
L
N
A
E
------------
I
-
I
-----
K
G
F
F
KN
D
M
P
-------------
I
D
G
I
I
G
G
P
P
C
Q
G
F
S
-----------------------
D
D
-
S
R
N
Q
L
Y
M
H
F
Y
R
L
V
S
E
L
Q
P
L
F
F
L
A
E
N
V
P
G
I
M
Q
E
K
Y
S
G
I
R
N
K
A
F
N
L
V
S
G
D
Y
D
I
L
D
-
P
I
K
V
K
A
S
D
Y
G
A
P
T
I
R
T
R
Y
F
F
I
G
V
-----------------
K
K
S
L
K
L
D
I
S
--
D
E
V
----
F
--
M
----
P
-------------------------
K
M
-----------------------
I
D
------------------------------
P
-------------
V
T
V
K
D
A
L
Y
G
L
P
D
I
I
D
A
NWQ
S
D
S
E
S
W
R
T
I
K
---
K
D
RKG
G
F
Y
E
K
L
W
G
Q
I
P
R
N
V
---
G
---
D
------
T
-
E
S
I
A
K
L
K
------------
N
N
-
I
I
S
G
C
T
------------------
G
--------------------------------------------------
T
-
L
H
S
--
K
--
I
V
Q
E
--------------------------------------------
R
------------
Y
--------------
A
S
L
------------
S
F
G
-------------------------------------------------
E
--
T
D
---------------
K
I
S
R
S
T
R
L
D
P
N
G
F
C
P
T
L
---------------------------
V
R
P
--
I
H
P
Y
H
P
--------------------
R
V
I
T
P
R
E
A
A
R
L
Q
G
F
P
D
W
F
R
F
-
H
V
-
T
K
W
H
S
F
R
Q
I
G
N
S
V
S
P
I
V
A
E
Y
I
L
K
G
L
---
Y
N
L
L
N
E
------------
6
PsiBlast_PDB
80.45
28%
-60
- C4 -
4MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
4
PsiBlast_PDB
79.77
28%
-59
- C4 -
1MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
15
PsiBlast_PDB
79.53
28%
-60
- C4 -
1SKM
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
9
PsiBlast_PDB
79.52
28%
-61
- C4 -
7MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
12
PsiBlast_PDB
79.38
28%
-60
- C4 -
10MH
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
10
PsiBlast_PDB
79.36
28%
-64
- C4 -
8MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
8
PsiBlast_PDB
79.28
28%
-61
- C4 -
6MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
16
PsiBlast_PDB
79.23
28%
-55
- C4 -
2C7O
7
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
19
PsiBlast_PDB
78.93
28%
-57
- C4 -
2HR1
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
17
PsiBlast_PDB
78.70
28%
-57
- C4 -
2C7P
9
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------
7
PsiBlast_PDB
78.64
28%
-61
- C4 -
5MHT
3
MTH1_HAEPH
A:
[13-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
I
D
L
F
A
G
L
G
G
F
R
L
A
L
E
S
C
G
A
--
E
C
V
Y
S
N
E
W
D
K
Y
A
Q
E
V
Y
E
M
N
F
G
E
K
P
E
--
G
D
I
T
Q
V
N
E
K
------------
T
-
I
-----
P
-------
D
-------------
H
D
I
L
C
A
G
F
P
C
Q
A
F
S
I
S
----
G
----
K
-
Q
-
K
GF----
E
D
S
-
R
G
T
-
L
F
F
D
I
A
R
I
V
R
E
K
K
P
K
V
V
F
M
E
N
V
K
N
F
A
S
H
D
N
G
N
T
L
E
V
V
K
N
T
M
N
E
L
D
Y
S
F
H
-
A
K
V
L
N
A
L
D
Y
G
I
P
Q
K
R
E
R
I
Y
M
I
C
F
-----------------
R
N
D
L
N
I-----
Q
N
F
----
Q
--
F
----
P
-------------------------
K
P
-----------------------
F
E
------------------------------
L
------------
N
T
F
V
K
D
L
L
--------------------
L
P
---
D
S
------
E
V
E
H
L
V
I
D
R
K
D
---
L
---
V
------
M
-
T
N
Q
E
I
E
Q
------------
T
T
P
K
T
V
R
L
G
------------------
I
--------------------------------------------------
V
-
G
K
G
--
G
--
Q
G
E
R
--------------------------------------------
I
------------
Y
----------------
S
------------
T
R
G
-------------------------------------------------
I
--
A
I
---------------
T
L
S
A
Y
G
G
G
I
F
A
K
-----
T
G
G
Y
L
-
V
----
N
--
G
-
K
----------
T
R
K
--
L
H
P
----------------------------
R
E
C
A
R
V
M
G
Y
P
D
S
Y
K
V
-
H
P
-
S
T
S
Q
A
Y
K
Q
F
G
N
S
V
V
I
N
V
L
Q
Y
I
A
Y
N
I
---
G
S
S
L
N
F
K
P
Y
---------