@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1449: (2016-03-24 )
MLRLGSHVSMSGKKMLLGASEEAASYGSNTFMIYTGAPQNTRRKPIEELNIEAGLEHMKAHDMADIVVHAPYIINIGNSVKPETFELGVNFLQSEIERTRALGAKQIVLHPGAHVGEGADKGIKQIIQGLNEALIHDQDVQIALETMAGKGSECGRTFEELAQIIDGVTHNELLSVTFDTCHTHDAGYDIVNDFDGVLNQFDKIVGIDRLKVLHINDSKNERGAHKDRHANIGFGHIGFDALHYIVHHPQLADVPKILETPYVGGDKASKKAPYKWEIAMLKNGEFDPDLLNKIQNS
Atome Classification :
(20 SA)
.........10.-.---......20........30........40........50.---....---...60.--......-..70.---.---.------------.----....80.-.......90........100.-......110....-------.---..120........130....--...140.......150.........160.......170.......180.....-..190--.--......200.......210.......220..----.....230.......240.......250.......260.....-----------------.-----------------.270.......280.......290.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRLGSHVSMSG-
K
---
K
M
L
LGAS
E
E
A
ASYGS
N
T
F
M
I
Y
TGAPQNTRRK
P
I
E
E
L
N
I
E
---
A
G
L
E
---
H
M
K
A
-H--
D
M
A
D
I
V
-
V
HA
P
Y
---
I
---
I
------------N----IGNSVK
P
-
E
T
F
E
L
G
V
N
F
L
Q
S
E
I
E
R
T
R
ALG-A
K
Q
I
V
LHPGAHVG-------E---
G
A
D
K
-
G
I
K
Q
I
I
Q
G
L
N
E
A
LIH--DQ
D
V
Q
I
A
L
E
T
MAGK--G
S
E
C
G
R
T
F
E
E
L
A
Q
I
I
D
GVTHN
E
L
L
S
V
T
F
DTCHTHDAG-Y
D
I
V
N
--
D
--
F
D
G
V
L
N
Q
F
D
K
I
VGI
D
R
L
K
V
L
H
INDSKNERGA----HKDRHANIGFGHI
G
F
D
A
L
H
Y
I
VHHP
Q
L
A
D
V
P
K
I
L
ETPYVGGDK-----------------A-----------------SKKAP
Y
K
W
E
I
A
M
L
KNGEF
D
P
D
L
L
N
K
IQNS
2
PsiBlast_PDB
99.55
78%
-96
- C4 -
1XP3
5
END4_BACAN
A:
[11-305]
-
L
K
I
G
S
H
V
S
M
S
G
-
K
---
K
M
L
L
A
A
S
E
E
A
V
S
Y
G
A
T
T
F
M
I
Y
T
G
A
P
Q
N
T
R
R
K
P
I
E
E
L
N
I
E
---
A
G
R
K
---
H
M
E
Q
-
N
--
G
I
E
E
I
I
-
I
H
A
P
Y
---
I
---
I
------------
N
----
V
G
N
T
T
K
P
-
E
T
F
Q
L
G
V
D
F
L
R
M
E
I
E
R
T
S
A
L
G
V
A
K
Q
I
V
L
H
P
G
A
H
V
G
-------
A
---
G
A
D
A
-
G
I
Q
Q
I
I
K
G
L
N
E
V
L
T
P
--
D
Q
T
V
N
I
A
L
E
T
M
A
G
K
--
G
T
E
C
G
R
S
F
E
E
I
A
K
I
I
D
G
V
K
Y
N
E
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
-
Y
D
I
V
N
--
N
--
F
D
G
V
L
N
E
F
D
K
I
V
G
I
D
R
L
Q
V
L
H
I
N
D
S
K
N
V
R
G
A
----
G
K
D
R
H
E
N
I
G
F
G
H
I
G
Y
K
A
L
H
H
I
V
H
H
P
Q
L
T
H
V
P
K
I
L
E
T
P
Y
V
G
E
D
K
-----------------
K
-----------------
D
K
K
P
P
Y
K
L
E
I
E
M
L
K
N
G
T
F
D
E
G
L
L
E
K
I
K
--
21
HHSearch
98.80
77%
-96
- C4 -
3AAL
4
END4_GEOKA
A:
[6-299]
-
L
K
I
G
S
H
V
S
M
S
G
-
K
---
K
M
L
L
A
A
S
E
E
A
A
S
Y
G
A
N
T
F
M
I
Y
T
G
A
P
Q
N
T
K
R
K
S
I
E
E
L
N
I
E
---
A
G
R
Q
---
H
M
Q
A
-
H
--
G
I
E
E
I
V
-
V
H
A
P
Y
---
I
---
I
------------
N
----
I
G
N
-
T
T
N
L
D
T
F
S
L
G
V
D
F
L
R
A
E
I
E
R
T
E
A
I
G
-
A
K
Q
L
V
L
H
P
G
A
H
V
G
-------
A
---
G
V
E
A
-
G
L
R
Q
I
I
R
G
L
N
E
V
L
T
R
--
E
Q
N
V
Q
I
A
L
E
T
M
A
G
K
--
G
S
E
C
G
R
T
F
E
E
L
A
Y
I
I
D
G
V
A
Y
N
D
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
-
Y
D
I
V
N
--
D
--
F
D
G
V
L
E
E
F
D
R
I
I
G
L
G
R
L
K
V
L
H
I
N
D
S
K
N
P
R
G
S
----
R
K
D
R
H
E
N
I
G
F
G
H
I
G
F
A
A
L
N
Y
I
V
H
H
P
Q
L
E
D
I
P
K
I
L
E
T
P
Y
V
G
E
D
K
-----------------
N
-----------------
N
K
K
P
P
Y
K
H
E
I
A
M
L
R
A
Q
S
F
D
D
Q
L
L
E
K
I
N
--
1
PsiBlast_PDB
98.51
76%
-97
- C4 -
3AAL
4
END4_GEOKA
A:
[6-298]
-
L
K
I
G
S
H
V
S
M
S
G
-
K
---
K
M
L
L
A
A
S
E
E
A
A
S
Y
G
A
N
T
F
M
I
Y
T
G
A
P
Q
N
T
K
R
K
S
I
E
E
L
N
I
E
---
A
G
R
Q
---
H
M
Q
A
-
H
--
G
I
E
E
I
V
-
V
H
A
P
Y
---
I
---
I
------------
N
----
I
G
N
T
T
N
L
-
D
T
F
S
L
G
V
D
F
L
R
A
E
I
E
R
T
E
A
I
G
-
A
K
Q
L
V
L
H
P
G
A
H
V
G
-------
A
---
G
V
E
A
-
G
L
R
Q
I
I
R
G
L
N
E
V
L
T
R
--
E
Q
N
V
Q
I
A
L
E
T
M
A
G
K
--
G
S
E
C
G
R
T
F
E
E
L
A
Y
I
I
D
G
V
A
Y
N
D
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
-
Y
D
I
V
N
--
D
--
F
D
G
V
L
E
E
F
D
R
I
I
G
L
G
R
L
K
V
L
H
I
N
D
S
K
N
P
R
G
S
----
R
K
D
R
H
E
N
I
G
F
G
H
I
G
F
A
A
L
N
Y
I
V
H
H
P
Q
L
E
D
I
P
K
I
L
E
T
P
Y
V
G
E
D
K
-----------------
N
-----------------
N
K
K
P
P
Y
K
H
E
I
A
M
L
R
A
Q
S
F
D
D
Q
L
L
E
K
I
---
22
HHSearch
75.24
34%
-89
- C4 -
3AAM
2
?
A:
[2-269]
-
P
R
Y
G
F
H
L
S
I
A
G
-
K
---
K
G
V
A
G
A
V
E
E
A
T
A
L
G
L
T
A
F
Q
I
F
A
K
S
P
R
S
W
R
P
R
A
L
S
P
A
E
V
E
---
A
F
R
A
---
L
R
E
A
S
G
--
G
L
-
P
A
V
-
I
H
A
S
Y
---
L
---
V
------------
N
----
L
G
A
-
E
G
--
E
L
W
E
K
S
V
A
S
L
A
D
D
L
E
K
A
A
L
L
G
-
V
E
Y
V
V
V
H
P
G
S
G
R
P
-------------
E
R
-
V
K
E
G
A
L
K
A
L
R
L
A
G
V
---
R
S
R
P
V
L
L
V
E
N
T
A
G
G
--
G
E
K
V
G
A
R
F
E
E
L
A
W
L
V
A
----
D
T
P
L
Q
V
C
L
D
T
C
H
A
Y
A
A
G
-
Y
D
V
A
E
--
D
--
P
L
G
V
L
D
A
L
D
R
A
V
G
L
E
R
V
P
V
V
H
L
N
D
S
V
G
G
L
G
S
----
R
V
D
H
H
A
H
L
L
Q
G
K
I
G
-
E
G
L
K
R
V
F
L
D
P
R
L
K
D
R
V
F
I
L
E
T
P
R
G
P
E
-----------------------------------------
E
D
A
W
N
L
R
V
F
R
A
W
L
E
E
----------
5
PsiBlast_PDB
73.16
35%
-88
- C4 -
3AAM
2
?
A:
[2-250]
-
P
R
Y
G
F
H
L
S
I
A
G
-
K
---
K
G
V
A
G
A
V
E
E
A
T
A
L
G
L
T
A
F
Q
I
F
A
K
S
P
R
S
W
R
P
R
A
L
S
P
A
E
V
E
---
A
F
R
A
---
L
R
E
A
-
S
--
G
G
L
P
A
V
-
I
H
A
S
Y
---
L
---
V
------------
N
----
L
G
--
A
E
G
-
E
L
W
E
K
S
V
A
S
L
A
D
D
L
E
K
A
A
L
L
G
-
V
E
Y
V
V
V
H
P
G
S
G
R
P
-------
E
---
R
V
K
E
-
G
A
---
L
K
A
L
R
L
A
G
V
R
--
S
R
P
V
L
L
-
V
E
N
T
A
G
G
--
G
E
K
V
G
A
R
F
E
E
L
A
W
L
V
----
A
D
T
P
L
Q
V
C
L
D
T
C
H
A
Y
A
A
G
-
Y
D
V
A
E
--
D
--
P
L
G
V
L
D
A
L
D
R
A
V
G
L
E
R
V
P
V
V
H
L
N
D
S
V
G
G
L
G
S
----
R
V
D
H
H
A
H
L
L
Q
G
K
I
G
-
E
G
L
K
R
V
F
L
D
P
R
L
K
D
R
V
F
I
L
E
T
P
----------------------------------------------------------------------
6
PsiBlast_PDB
72.98
33%
-81
- C4 -
1QUM
6
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
K
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
H
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
P
A
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
E
T
-----------------------------------------------------------------------
3
PsiBlast_PDB
72.95
35%
-85
- C4 -
2X7V
3
END4_THEMA
A:
[1-262]
M
I
K
I
G
A
H
M
P
I
S
------
K
G
F
D
R
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
---
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
---
A
A
T
K
F
K
R
E
M
K
K
-
H
GI
D
W
E
N
A
F
-
C
H
S
G
Y
---
L
---
I
------------
N
----
L
A
-
S
P
K
D
-
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
G
-------
T
---
G
E
E
E
-
G
I
D
R
I
V
R
G
L
N
E
V
L
N
N
--
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
--
G
G
N
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
-
Y
D
I
T
K
--
K
E
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
G
A
----
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
E
I
Q
E
V
P
W
I
L
E
T
P
----------------------------------------------------------------------
9
PsiBlast_PDB
72.74
33%
-80
- C4 -
4K1G
7
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
K
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
A
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
P
A
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
E
T
-----------------------------------------------------------------------
4
PsiBlast_PDB
72.69
35%
-86
- C4 -
2X7W
4
END4_THEMA
A:
[1-262]
M
I
K
I
G
A
H
M
P
I
S
------
K
G
F
D
R
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
---
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
---
A
A
T
K
F
K
R
E
M
K
K
-
H
GI
D
W
E
N
A
F
-
C
H
S
G
Y
---
L
---
I
------------
N
----
L
A
-
S
P
K
D
-
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
G
-------
T
---
G
E
E
E
-
G
I
D
R
I
V
R
G
L
N
E
V
L
N
N
--
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
--
G
G
N
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
-
Y
D
I
T
K
--
K
E
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
G
A
----
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
E
I
Q
E
V
P
W
I
L
E
T
P
----------------------------------------------------------------------
20
PsiBlast_CBE
72.60
33%
-82
- C4 -
4K1G
8
END4_ECOLI
B:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
EFK
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
A
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
PA
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
E
T
-----------------------------------------------------------------------
19
PsiBlast_CBE
72.26
33%
-81
- C4 -
2NQJ
1
END4_ECOLI
B:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
EFK
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
H
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
PA
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
Q
T
-----------------------------------------------------------------------
10
PsiBlast_PDB
71.72
33%
-80
- C4 -
2NQ9
6
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
K
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
H
D
S
A
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
P
A
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
E
T
-----------------------------------------------------------------------
7
PsiBlast_PDB
71.51
33%
-78
- C4 -
2NQH
4
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
K
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
H
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
P
A
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
Q
T
-----------------------------------------------------------------------
8
PsiBlast_PDB
71.47
33%
-80
- C4 -
2NQJ
5
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
-
G
-----
L
A
N
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
K
A
A
C
E
---
K
Y
H
--
Y
--
T
S
A
Q
I
L
-
P
H
D
S
Y
---
L
---
I
------------
N
----
L
G
H
P
V
T
--
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
-------
Q
---
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
--
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
S
N
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
-
Y
D
L
R
T
P
A
E
--
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
G
S
----
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
R
F
D
G
I
P
L
I
L
Q
T
-----------------------------------------------------------------------
23
HHSearch
58.59
21%
-71
* C4 *
3WQO
2
Y1311_METJA
A:
[16-286]
D
M
K
F
G
V
S
S
L
V
F
L
-
P
---
E
S
L
T
S
S
M
E
K
I
A
E
H
N
F
D
A
W
E
I
V
C
E
G
T
H
-----
Y
L
S
P
K
N
I
K
---
Y
L
M
E
---
L
R
D
R
-
Y
--
E
V
-
E
I
V
-
V
H
A
P
F
---
S
D--
L
------------
N
----
P
A
S
-
M
N
E
-
R
V
R
K
L
T
V
E
C
I
R
D
A
I
E
G
A
F
E
L
D
-
S
E
V
V
V
V
H
P
G
Y
I
P
E
-------
L
WSN
Y
V
S
E
-
I
L
D
N
N
F
S
T
L
S
E
I
V
E
I
A
E
D
Y
G
I
K
I
G
L
E
N
M
P
N
F
--
R
G
V
L
G
I
T
P
E
S
L
L
E
I
V
K
D
I
D
-
S
K
N
L
G
I
T
F
D
I
G
H
A
N
T
A
G
-
N
P
A
----
E
--
F
V
E
K
L
Q
N
I
G
-----
I
G
I
I
H
V
H
A
H
D
N
N
G
--------
Y
D
D
E
H
L
K
I
G
E
G
N
I
N
F
I
E
V
L
E
K
L
K
E
I
G
Y
D
G
-
V
I
S
I
E
N
K
N
I
R
D
A
--------------------------------------
V
K
S
K
E
I
L
K
E
Y
L
E
I
V
N
E
K
V
A
--------
35
HHSearch
57.04
11%
-73
- C4 -
2QUL
1
DT3E_PSECI
A:
[1-289]
M
N
K
V
G
M
F
Y
T
Y
W
S
-
T
EWM
V
D
F
P
A
T
A
K
R
I
A
G
L
G
F
D
L
M
E
I
S
L
G
E
F
H
-----
N
L
S
D
A
K
K
R
---
E
L
K
A
---
V
A
D
D
-
L
--
G
L
-
T
V
M
-
C
C
I
G
L
K
S-
E
---
Y
------------
D
----
F
A
S
-
P
D
K
-
S
V
R
D
A
G
T
E
Y
V
K
R
L
L
D
D
C
H
L
L
G
-
A
P
V
F
A
G
L
T
F
C
A
W
P
QSPPLDM
K
---
D
K
R
P
-
Y
V
D
R
A
I
E
S
V
R
R
V
I
K
V
A
E
D
Y
G
I
I
Y
A
L
E
V
V
N
R
F
--
E
Q
W
L
C
N
D
A
K
E
A
I
A
F
A
D
A
V
D
-
S
P
A
C
K
V
Q
L
D
T
F
H
M
N
I
E
E
-
T
S
F
--------
R
D
A
I
L
A
C
K
-----
G
K
M
G
H
F
H
L
G
E
A
N
-------------
R
L
P
P
G
E
G
R
L
P
W
D
E
I
F
G
A
L
K
E
I
G
Y
D
G
-
T
I
V
M
E
P
F
M
R
K
G
G
S
V
S
R
A
V
GVWRDMSNGAT
D
E
-----------------
E
M
D
E
R
A
R
R
S
L
Q
F
V
R
D
K
L
------------
33
HHSearch
56.05
13%
-78
- C4 -
1K77
5
YGBM_ECOLI
A:
[1-259]
M
P
R
F
A
A
N
L
S
M
M
F
-
T
E--
V
P
F
I
E
R
F
A
A
A
R
K
A
G
F
D
A
V
E
F
L
F
P
Y
----------
N
Y
S
T
L
---
Q
I
Q
K
---
Q
L
E
Q
-
N
--
H
L
-
T
L
A
L
F
N
T
A
P
---
G
D--
I
------------
N
AGEW
G
L
S
-
A
L
P
-
G
R
E
H
E
A
H
A
D
I
D
L
A
L
E
Y
A
L
A
L
N
-
C
E
Q
V
H
V
M
A
G
V
V
P
A
G------
E
---
D
A
E
R
-
Y
R
A
V
F
I
D
N
I
R
Y
A
A
D
R
F
A
P
H
G
K
R
I
L
V
E
A
L
S
P
G
VK
P
H
Y
L
F
S
S
Q
Y
Q
A
L
A
I
V
E
E
V
A
-
R
D
N
V
F
I
Q
L
D
T
F
H
A
Q
K
V
D
-
G
N
L
--------
T
H
L
I
R
D
Y
A
-----
G
K
Y
A
H
V
Q
I
A
G
L
P
D
------------
R
H
E
P
D
D
G
E
I
N
Y
P
W
L
F
R
L
F
D
E
V
G
Y
Q
G
-
W
I
G
C
E
Y
K
P
R
G
L
------------------------------------------
T
E
E
G
L
G
W
F
D
A
W
R
G
-----------
31
HHSearch
55.28
13%
-66
- C4 -
3VNI
1
?
A:
[2-290]
-
M
K
H
G
I
Y
Y
A
Y
W
E
-
Q
EWE
A
D
Y
K
Y
Y
I
E
K
V
A
K
L
G
F
D
I
L
E
I
A
A
S
P
L
P
-----
F
Y
S
D
I
Q
I
N
---
E
L
K
A
---
C
A
H
G
-
N
--
G
I
-
T
L
T
V
G
H
G
P
S
---
A
E--
Q
------------
N
----
L
S
S
-
P
D
P
-
D
I
R
K
N
A
K
A
F
Y
T
D
L
L
K
R
L
Y
K
L
D
-
V
H
L
I
G
G
A
L
Y
S
Y
W
P
IDYTKT-
I
---
D
K
K
G
-
D
W
E
R
S
V
E
S
V
R
E
V
A
K
V
A
E
A
C
G
V
D
F
C
L
E
V
L
N
R
F
--
E
N
Y
L
I
N
T
A
Q
E
G
V
D
F
V
K
Q
V
D
-
H
N
N
V
K
V
M
L
D
T
F
H
M
N
I
E
E
-
D
S
I
--------
G
G
A
I
R
T
A
G
-----
S
Y
L
G
H
L
H
T
G
E
C
N
R
-------------
K
V
P
G
R
G
R
I
P
W
V
E
I
G
E
A
L
A
D
I
G
Y
N
G
-
S
V
V
M
E
P
F
V
R
M
G
G
T
-----------------
V
G
S
N
I
KVWRDISNGAD
E
K
M
L
D
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
C
----------
29
HHSearch
55.23
17%
-71
- C4 -
3TVA
4
?
A:
[11-288]
-
W
P
I
G
V
F
T
S
V
D
------
A
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
A
P
H
P
H
T
-----
R
T
R
E
H
A
Q
---
A
F
R
A
---
K
C
D
A
-
A
--
G
I
-
Q
V
T
-
V
I
F
G
G
---
F
---
D
GESYAD
I
P
T
T
A
R
T
----
V
G
L
-
V
P
L
-
E
T
R
A
S
R
V
A
E
M
K
E
I
S
D
F
A
S
W
V
G
-
C
P
A
I
G
L
H
I
G
F
V
P
E
-----------
S
S
S
P
-
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
---------
E
S
A
D
H
L
L
E
F
I
E
D
V
N
-
R
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
G
N
P
--------
I
E
A
L
R
K
V
A
-----
R
Y
V
R
S
I
H
C
K
D
A
L
W
A
P
V
N
ERGK
S
W
G
Q
E
V
A
L
G
T
G
D
V
G
M
E
A
Y
L
T
T
L
W
E
I
G
Y
R
G
-
P
L
T
I
E
R
E
I
P
H
D
P
------------------
V
-----------------
Q
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
--------
36
HHSearch
54.63
15%
-70
- C4 -
2ZVR
-
Y416_THEMA
A:
[1-266]
-
M
K
L
S
L
V
I
S
T
S
D
F
K
---
G
D
L
R
K
G
M
E
L
A
K
R
V
G
Y
Q
A
V
E
I
A
V
R
D
P
--------
S
I
V
D
W
N
---
E
V
K
I
---
L
S
E
E
-
L
--
N
L
-
P
I
C
-
A
I
G
T
G
Q
A
Y
L
A
DG
L
------------
S
----
L
T
H
-
P
N
D
-
E
I
R
K
K
A
I
E
R
V
V
K
H
T
E
V
A
G
M
F
G
-
A
L
V
I
I
G
L
V
R
G
R
R
E
G------
R
---
S
Y
E
E
-
T
E
E
L
F
I
E
S
M
K
R
L
L
E
L
--
T
E
H
A
K
F
V
I
E
P
L
N
R
Y
--
E
T
D
F
I
N
T
I
D
D
A
L
R
I
L
R
K
I
N
-
S
N
R
V
G
I
L
A
D
T
F
H
M
N
I
E
E
-
V
N
I
--------
P
E
S
L
K
R
A
G
-----
E
K
L
Y
H
F
H
V
A
D
S
N
R
-------------
W
A
P
G
C
G
H
F
D
F
R
S
V
F
N
T
L
K
E
I
G
Y
N
R
-
Y
V
S
V
E
C
L
P
L
P
G
G
-------------------------------------
M
E
E
A
A
E
I
A
F
K
T
L
K
E
L
I
------------