@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1578: (2016-03-26 )
MEKNIDVLQNWLKDQGAEVGFLTDPENIAYFSGYHSEPHERVLGLAVFSDSEPFLFTPALEVEDVRGGDWTHPAYGYNDTENPFTIIADEIKKRVANPSKFAIEKKHMSVDRYEQLGGLFSGSSFIPIEHKIEQIRLIKTEAELKILKEAALLADYAVQVGVDEIAEGKTEAEIVAKIEYEMKKKGVTAMSFDTMVLTGKNGALPHGTPGETKIKKGDLVLFDLGVVHKGYCSDITRTVAFGDISDEQKKIYDTVLEAQIAAVEKVKAGVKASEIDLTARNIIREAGFGDYFPHRLGHGLGASVHEFPSITETNSMELQENMVFTIEPGIYVPGVAGVRIEDDLVVTKDGVQVLTEFPKTLQVIE
Atome Classification :
(31 SA)
.........10........20.....-----...-----30....-.-..-.40........50........-----------60--....--------..---...70........80.......----.90.....-----...-100--........110.......120....--..--.130.......140.......150.......160.......170.......180...-....190.......200.......---210.......220.......-230.......240........250......----------------------.260....-...270....-...280...----..--------------..-290---........300--......---.310.......320.......330..---------..---------...340..-.....350....-...360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
N
I
D
V
L
Q
N
W
L
K
DQGAEVGFLTDPE-----
N
I
A
-----
Y
FSGYH-S-
E
P
-
H
E
R
V
L
G
L
A
V
FSDSE
P
F
L
F
TPA-----------
L
---
E
V
E
D--------VR---GGDWTHPAYGYNDTEN
P
F
T
I
I
A
----
D
E
I
K
K
RVA-----NPS-
K
F
---
A
I
E
K
KHM
S
V
D
R
Y
E
Q
L
G
GLFSGS
S
F
I
--P
I
--
E
HKI
E
Q
I
R
L
I
K
T
E
A
E
L
K
I
L
K
E
A
A
L
L
A
D
Y
A
V
QV
G
V
D
E
I
AEGK
T
E
A
E
I
V
A
K
I
E
Y
E
M
K
KK-G
V
T
A
M
S
F
D
T
M
V
L
TGKNGALPHGTP---GE
T
K
IKKG
D
L
V
L
F
DLGVVHK-
G
Y
C
S
D
I
T
R
T
V
AF-GDI
S
D
E
Q
K
K
I
Y
D
T
V
L
E
A
----------------------
Q
I
A
A
V
E
K
V
-
K
AGVK
A
S
E
I
D
-
L
T
A
R
N
I
I
R
E----AG--------------FG-DY----
F
P
H
R
LGHGLGA--
S
V
HEFP---SITETNS
M
E
L
QE
N
M
V
F
T
IEP
G
I
Y
VPG---------VA---------G
V
R
IED
D
L
-
V
V
TK
D
G
V
Q
V
L
T
E-F
P
K
T
LQVIE
72
HHSearch
97.16
37%
-78
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[4-351]
M
N
E
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
-----
N
V
Y
-----
Y
I
S
G
A
S
-
P
-
L
A
-
G
---
G
Y
I
L
I
T
-
G
E
S
A
T
L
Y
V
P
E
-----------
L
---
E
Y
E
M
--------
A
K
---
E
E
S
N
I
-
P
V
E
K
F
K
K
M
----
D
E
F
Y
----
K
A
L
E
---------
G
I
K
-
S
L
---
G
I
E
S
-
S
L
P
Y
G
F
I
E
E
L
K
K
K
A
N
I
K
E
F
K
--
K
V
--
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
-
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
----------------------
Q
K
K
A
V
E
S
A
-
K
P
G
I
T
A
K
E
L
D
-
S
I
A
R
N
I
I
A
E
----
Y
G
--------------
Y
G
-
E
Y
----
F
N
H
S
L
G
H
G
V
G
L
--
E
V
H
E
W
P
---
R
V
S
Q
Y
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
---------
I
G
---------
G
V
R
I
E
D
T
I
-
L
I
T
K
N
G
S
K
R
L
T
K
-
T
E
R
E
L
I
---
62
Fugue
94.58
40%
-78
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
-------
L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
-----
N
V
Y
-----
Y
F
S
G
T
S
-
P
-
L
G
-
G
----
G
Y
I
I
V
D
G
D
E
A
T
L
Y
V
P
E
-----------
L
---
E
Y
E
M
--------
A
K
---
E
E
S
-
K
L
P
V
V
K
F
K
K
F
------------
D
E
I
Y
E
I
L
K
-----
N
T
E
-
T
L
---
G
I
E
G
T
-
L
S
Y
S
M
V
E
N
F
K
E
K
S
V
-
K
E
F
K
--
K
I
--
D
D
V
I
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
-
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
R
E
I
Y
E
I
V
L
E
A
----------------------
Q
K
R
A
V
E
A
A
-
K
P
G
M
T
A
K
E
L
D
-
S
I
A
R
E
I
I
K
E
----
Y
G
--------------
Y
G
-
D
Y
----
F
I
H
S
L
G
H
G
V
G
L
--
E
I
H
E
W
P
---
R
I
S
Q
Y
D
E
T
V
L
K
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
---------
L
G
---------
G
V
R
I
E
D
T
V
-
L
I
T
E
N
G
A
K
R
L
T
K
-
T
E
R
------
3
PsiBlast_PDB
94.47
38%
-77
- C1 -
3Q6D
2
?
A:
[4-356]
M
E
K
-
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
-----
Y
M
A
N
F
T
-
G
-
T
A
------
G
V
V
L
I
S
K
K
R
A
Q
F
I
T
D
F
-----------
R
---
Y
V
E
Q
--------
A
--------
S
K
Q
A
V
G
Y
E
I
V
Q
H
A
G
L
I
I
-----
D
E
V
A
K
Q
V
K
E
L
---
G
I
Q
-
K
L
---
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
--
P
T
--
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
----------------------
Q
L
R
G
V
N
G
I
-
K
A
G
L
T
G
R
E
A
D
-
A
L
T
R
D
Y
I
T
E
----
K
G
--------------
Y
G
-
E
Y
----
F
G
H
S
T
G
H
G
I
G
L
--
E
I
H
E
A
P
---
G
L
A
F
R
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
---------
I
G
---------
G
V
R
I
E
D
D
I
-
I
V
T
S
E
G
N
E
V
I
T
K
-
S
P
K
E
L
I
I
L
-
22
PsiBlast_CBE
93.78
38%
-75
- C1 -
3Q6D
2
?
D:
[4-356]
M
E
K
-
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
-----
Y
M
A
N
F
T
-
G
-
T
A
------
G
V
V
L
I
S
K
K
R
A
Q
F
I
T
D
F
-----------
R
---
Y
V
E
Q
--------
A
--------
S
K
Q
A
V
G
Y
E
I
V
Q
H
A
G
L
I
I
-----
D
E
V
A
K
Q
V
K
EL---
G
I
Q
-
K
L
---
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
--
P
T
--
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
----------------------
Q
L
R
G
V
N
G
I
-
K
A
G
L
T
G
R
E
A
D
-
A
L
T
R
D
Y
I
T
E
----
K
G
--------------
Y
G
-
E
Y
----
F
G
H
S
T
G
H
G
I
G
L
--
E
I
H
E
A
P
---
G
L
A
F
R
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
---------
I
G
---------
G
V
R
I
E
D
D
I
-
I
V
T
S
E
G
N
E
V
I
T
K
-
S
P
K
E
L
I
I
L
-
24
PsiBlast_CBE
93.53
38%
-75
- C1 -
3Q6D
1
?
B:
[4-356]
M
E
K
-
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
-----
Y
M
A
N
F
T
-
G
-
T
A
------
G
V
V
L
I
S
K
K
R
A
Q
F
I
T
D
F
-----------
R
---
Y
V
E
Q
--------
A
--------
S
K
Q
A
V
G
Y
E
I
V
Q
H
A
G
L
I
I
-----
D
E
V
A
K
Q
V
K
EL---
G
I
Q
-
K
L
---
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
--
P
T
--
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
----------------------
Q
L
R
G
V
N
G
I
-
K
A
G
L
T
G
R
E
A
D
-
A
L
T
R
D
Y
I
T
E
----
K
G
--------------
Y
G
-
E
Y
----
F
G
H
S
T
G
H
G
I
G
L
--
E
I
H
E
A
P
---
G
L
A
F
R
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
---------
I
G
---------
G
V
R
I
E
D
D
I
-
I
V
T
S
E
G
N
E
V
I
T
K
-
S
P
K
E
L
I
I
L
-
23
PsiBlast_CBE
93.15
38%
-75
- C1 -
3Q6D
1
?
C:
[4-355]
M
E
K
-
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
-----
Y
M
A
N
F
T
-
G
-
T
A
------
G
V
V
L
I
S
K
K
R
A
Q
F
I
T
D
F
-----------
R
---
Y
V
E
Q
--------
A
--------
S
K
Q
A
V
G
Y
E
I
V
Q
H
A
G
L
I
I
-----
D
E
V
A
K
Q
V
K
EL---
G
I
Q
-
K
L
---
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
--
P
T
--
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
----------------------
Q
L
R
G
V
N
G
I
-
K
A
G
L
T
G
R
E
A
D
-
A
L
T
R
D
Y
I
T
E
----
K
G
--------------
Y
G
-
E
Y
----
F
G
H
S
T
G
H
G
I
G
L
--
E
I
H
E
A
P
---
G
L
A
F
R
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
---------
I
G
---------
G
V
R
I
E
D
D
I
-
I
V
T
S
E
G
N
E
V
I
T
K
-
S
P
K
E
L
I
I
--
6
PsiBlast_PDB
92.90
39%
-76
- C1 -
4FKC
7
?
A:
[16-367]
-
K
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
-----
N
F
Y
-----
Y
L
T
G
F
N
-
P
L
G
T
-
L
E
R
L
F
V
L
I
L
P
S
E
G
L
L
T
A
I
A
P
R
-----------
L
YEK
E
L
E
E
--------
F
N
---
G
-----
E
V
V
L
W
S
D
S
E
N
P
Y
K
I
F
A
----
T
K
I
K
E
T
F
K
-----
E
G
E
-
K
L
---
L
I
D
D
T
-
M
P
V
G
V
F
L
K
A
K
D
I
F
D
K
Y
S
L
H
--
P
I
--
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
E
F
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
-
G
Y
C
S
D
V
T
R
T
V
V
V
-
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
----------------------
Q
E
T
A
V
Q
K
V
-
A
E
G
I
P
A
E
V
V
D
-
A
T
A
R
G
I
I
S
K
----
Y
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
I
--
D
V
H
E
E
P
---
Y
I
S
P
G
N
K
K
I
L
K
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
---------
K
F
---------
G
V
R
I
E
D
D
V
A
L
V
D
K
K
G
I
R
L
-------------
1
PsiBlast_PDB
92.43
37%
-79
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
-------
L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
-----
N
V
Y
-----
Y
F
S
G
---
T
-
S
P
-
L
G
G
--
G
Y
I
I
V
D
G
D
E
A
T
L
Y
V
P
E
-----------
L
---
E
Y
E
M
--------
A
K
----------------
E
E
S
K
L
P
V
V
K
F
KKF
D
E
I
Y
E
I
L
K
-----
N
T
E
-
T
L
---
G
I
E
G
T
-
L
S
Y
S
M
V
E
N
F
K
E
K
S
-
V
K
E
F
K
--
K
I
--
D
D
V
I
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
-
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
R
E
I
Y
E
I
V
L
E
A
----------------------
Q
K
R
A
V
E
A
A
-
K
P
G
M
T
A
K
E
L
D
-
S
I
A
R
E
I
I
K
E
----
Y
G
--------------
Y
G
-
D
Y
----
F
I
H
S
L
G
H
G
V
G
L
--
E
I
H
E
W
P
---
R
I
S
Q
Y
D
E
T
V
L
K
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
---------
L
G
---------
G
V
R
I
E
D
T
V
-
L
I
T
E
N
G
A
K
R
L
T
K
-
T
E
R
------
61
Fugue
92.36
35%
-79
- C1 -
1WN1
2
?
A:
[1-356]
--
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
-----
Y
L
T
G
L
R
L
H
-
E
V
-
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
-----------
L
---
Y
E
N
V
--------
V
N
-------
N
F
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
----
E
I
L
E
E
L
G
I
-----
S
K
G
-
R
I
---
L
I
E
D
-
T
M
R
A
D
W
L
I
G
I
M
K
L
-
G
K
F
T
F
Q
--
P
L
--
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
L
--
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
----------------------
Q
E
S
A
F
K
A
V
-
R
E
G
I
K
A
K
D
V
D
-
S
R
A
R
E
V
I
S
K
----
A
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
L
--
D
V
H
E
E
P
---
Y
I
G
P
D
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
---------
L
G
---------
G
V
R
I
E
D
D
I
-
V
V
D
E
G
K
G
R
R
L
T
K
-
A
E
R
E
L
I
I
L
-
71
HHSearch
92.27
35%
-79
- C1 -
1WN1
2
?
A:
[1-356]
--
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
-----
Y
L
T
G
L
R
-
L
-
H
E
V
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
-----------
L
---
Y
E
N
V
--------
V
N
---
N
--
F
--
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
----
E
I
L
E
E
L
G
I
-----
S
K
G
-
R
I
---
L
I
E
D
-
T
M
R
A
D
W
L
I
G
I
M
-
K
L
G
K
F
T
F
Q
--
P
L
--
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
L
-
S
D
G
-
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
----------------------
Q
E
S
A
F
K
A
V
-
R
E
G
I
K
A
K
D
V
D
-
S
R
A
R
E
V
I
S
K
----
A
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
L
--
D
V
H
E
E
P
---
Y
I
G
P
D
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
---------
L
G
---------
G
V
R
I
E
D
D
I
-
V
V
D
E
G
K
G
R
R
L
T
K
-
A
E
R
E
L
I
I
L
-
69
HHSearch
91.71
36%
-79
- C1 -
3Q6D
2
?
A:
[3-356]
A
M
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
-----
Y
M
A
N
F
T
-
G
-
T
A
-----
G
V
V
L
I
S
K
K
-
R
A
Q
F
I
T
D
F
-----------
R
---
Y
V
E
Q
--------
A
S
---
K
Q
A
V
G
Y
E
I
V
Q
H
A
--
G
L
I
I
D
E
V
A
----
K
Q
V
K
E
L
G
-------
I
Q
-
K
L
---
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
--
P
T
--
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
-
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
----------------------
Q
L
R
G
V
N
G
I
-
K
A
G
L
T
G
R
E
A
D
-
A
L
T
R
D
Y
I
T
E
----
K
G
--------------
Y
G
-
E
Y
----
F
G
H
S
T
G
H
G
I
G
L
--
E
I
H
E
A
P
---
G
L
A
F
R
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
---------
I
G
---------
G
V
R
I
E
D
D
I
-
I
V
T
S
E
G
N
E
V
I
T
K
-
S
P
K
E
L
I
I
L
-
25
PsiBlast_CBE
91.71
39%
-79
- C1 -
4RGZ
3
?
N:
[6-357]
-
K
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
-----
N
F
Y
-----
Y
L
T
G
F
N
-
P
L
G
T
-
L
E
R
L
F
V
L
I
L
P
S
E
G
L
L
T
A
I
A
P
R
-----------
L
YEK
E
L
E
E
--------
F
N
---
G
-----
E
V
V
L
W
S
D
S
E
N
P
Y
K
I
F
A
----
T
K
I
K
E
T
F
K
-----
E
G
E
-
K
L
---
L
I
D
D
T
-
M
P
V
G
V
F
L
K
A
K
D
I
F
D
K
Y
S
L
H
--
P
I
--
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
E
F
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
-
G
Y
C
S
D
V
T
R
T
V
V
V
-
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
----------------------
Q
E
T
A
V
Q
K
V
-
A
E
G
I
P
A
E
V
V
D
-
A
T
A
R
G
I
I
S
K
----
Y
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
I
--
D
V
H
E
E
P
---
Y
I
S
P
G
N
K
K
I
L
K
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
---------
K
F
---------
G
V
R
I
E
D
D
V
A
L
V
D
K
K
G
I
R
L
-------------
70
HHSearch
90.81
33%
-81
- C1 -
2ZSG
8
?
A:
[2-359]
--
D
R
S
E
R
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
NSA
R
A
S
S
V
-----
Y
F
S
G
F
T
-
G
-
S
------
F
S
I
I
L
I
S
E
N
T
R
L
L
I
T
D
S
-----------
R
---
Y
T
V
Q
--------
A
K
---
Q
E
T
D
-
F
E
V
R
E
V
----
D
F
I
D
V
L
K
----
K
T
V
N
D
L
-------
K
I
K
-
T
I
---
A
L
E
E
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
D
R
K
F
I
--
G
I
--
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
-
N
Y
C
A
D
I
T
R
V
V
S
I
-
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
----------------------
Q
E
R
A
L
K
I
A
-
K
A
G
V
T
G
K
L
L
D
-
S
V
A
R
E
F
I
R
E
----
K
G
--------------
Y
G
-
E
F
----
F
G
H
S
L
G
H
G
I
G
L
--
E
V
H
E
G
P
---
A
I
S
F
R
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
---------
K
F
---------
G
I
R
I
E
E
D
V
-
V
L
K
E
Q
G
C
E
I
L
T
T
-
L
P
R
S
I
F
V
V
-
5
PsiBlast_PDB
89.66
39%
-73
- C1 -
4RGZ
2
?
A:
[6-357]
-
K
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
-----
N
F
Y
-----
Y
L
T
G
F
N
-
P
L
G
T
-
L
E
R
L
F
V
L
I
L
P
S
E
G
L
L
T
A
I
A
P
R
-----------
L
YEK
E
L
E
E
--------
F
N
---
G
-----
E
V
V
L
W
S
D
S
E
N
P
Y
K
I
F
A
----
T
K
I
K
E
T
F
K
-----
E
G
E
-
K
L
---
L
I
D
D
T
-
M
P
V
G
V
F
L
K
A
K
D
I
F
D
K
Y
S
L
H
--
P
I
--
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
E
F
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
-
G
Y
C
S
D
V
T
R
T
V
V
V
-
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
----------------------
Q
E
T
A
V
Q
K
V
-
A
E
G
I
P
A
E
V
V
D
-
A
T
A
R
G
I
I
S
K
----
Y
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
I
--
D
V
H
E
E
P
---
Y
I
S
P
G
N
K
K
I
L
K
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
---------
K
F
---------
G
V
R
I
E
D
D
V
A
L
V
D
K
K
G
I
R
L
-------------
4
PsiBlast_PDB
88.88
34%
-83
- C1 -
2ZSG
8
?
A:
[7-359]
-------
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
-----
N
S
A
R
A
S
S
V
Y
F
S
G
F
T
-
G
-
S
------
F
S
I
I
L
I
S
E
N
T
R
L
L
I
T
D
S
RY
T
V
Q
A
K
Q
E
T
D
F
---
E
V
R
E
--------
V
------
D
F
I
----------------------
D
V
L
K
K
T
V
-----
N
D
L
-
K
I
K
T
I
A
L
E
E
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
D
R
K
F
I
--
G
I
--
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
-
N
Y
C
A
D
I
T
R
V
V
S
I
-
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
----------------------
Q
E
R
A
L
K
I
A
-
K
A
G
V
T
G
K
L
L
D
-
S
V
A
R
E
F
I
R
E
----
K
G
--------------
Y
G
-
E
F
----
F
G
H
S
L
G
H
G
I
G
L
--
E
V
H
E
G
P
---
A
I
S
F
R
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
---------
K
F
---------
G
I
R
I
E
E
D
V
-
V
L
K
E
Q
G
C
E
I
L
T
T
-
L
P
R
S
I
F
V
V
-
7
PsiBlast_PDB
87.29
35%
-77
- C1 -
1WN1
2
?
A:
[10-356]
-----------
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
-----
Y
L
T
G
L
R
L
H
-
E
V
-
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
-----------
L
----
Y
E
N
--------
V
V
---
N
---
N
F
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
----
E
I
L
E
E
L
G
I
-----
S
K
G
-
R
I
---
L
I
E
----
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
--
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
L
-
S
-
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
----------------------
Q
E
S
A
F
K
A
V
-
R
E
G
I
K
A
K
D
V
D
-
S
R
A
R
E
V
I
S
K
----
A
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
L
--
D
V
H
E
E
P
---
Y
I
G
P
D
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
---------
L
G
---------
G
V
R
I
E
D
D
I
-
V
V
D
E
G
K
G
R
R
L
T
K
-
A
E
R
E
L
I
I
L
-
10
PsiBlast_PDB
87.23
30%
-84
- C1 -
4R60
3
?
A:
[34-389]
-
Q
Q
R
I
E
R
A
R
V
L
M
R
A
Q
G
V
D
A
L
L
I
G
A
G
T
-----
S
L
R
-----
Y
F
S
G
V
P
-
W
-
G
A
-
S
E
R
L
V
A
L
L
L
T
T
E
G
D
P
V
L
I
C
P
A
-----------
F
---
E
E
G
S
L
D
A
V
LQLP
V
R
---
K
R
L
W
-------
E
E
H
E
D
P
Y
A
L
V
V
----
Q
A
M
D
E
Q
H
A
HALAL
D
P
G
I
A
F
---
A
V
---
H
T
G
L
R
A
H
--
L
G
T
A
I
R
D
A
G
A
I
---------
I
D
G
C
R
M
C
K
S
P
A
E
L
A
L
M
Q
Q
A
C
D
M
T
L
L
V
Q
R
L
A
A
G
I
A
H
E
G
I
G
T
D
Q
L
V
R
F
I
D
E
A
H
R
A
L
-
G
A
D
N
G
S
T
F
C
I
V
Q
F
G
H
A
T
A
F
P
H
G
I
P
---
G
V
Q
H
L
R
A
G
E
L
V
L
I
D
T
G
C
T
V
Q
-
G
Y
H
S
D
I
T
R
T
W
I
Y
-
G
T
P
S
D
A
Q
Q
R
I
W
E
L
E
L
A
A
----------------------
Q
A
A
A
F
A
A
V
-
R
P
G
V
A
C
E
A
V
D
-
Q
A
A
R
A
V
L
Q
A
----
A
G
--------------
L
G
P
D
Y
RLPG
L
P
H
R
T
G
H
G
C
G
L
--
A
I
H
E
A
P
---
Y
L
V
R
G
N
R
Q
P
L
Q
P
G
M
C
A
S
N
E
P
M
I
V
V
P
G
---------
A
F
---------
G
V
R
L
E
D
H
F
-
Y
V
T
D
T
G
A
Q
W
F
T
-----------
26
PsiBlast_CBE
86.46
35%
-72
- C1 -
1WN1
2
?
B:
[10-356]
-----------
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
-----
Y
L
T
G
L
R
L
H
-
E
V
-
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
-----------
L
----
Y
E
N
--------
V
V
---
N
---
N
F
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
----
E
I
L
E
E
L
G
I
-----
S
K
G
-
R
I
---
L
I
E
----
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
FQ
P
L
--
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
L
-
S
-
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
----------------------
Q
E
S
A
F
K
A
V
-
R
E
G
I
K
A
K
D
V
D
-
S
R
A
R
E
V
I
S
K
----
A
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
L
--
D
V
H
E
E
P
---
Y
I
G
P
D
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
---------
L
G
---------
G
V
R
I
E
D
D
I
-
V
V
D
E
G
K
G
R
R
L
T
K
-
A
E
R
E
L
I
I
L
-
8
PsiBlast_PDB
85.99
35%
-74
- C1 -
2HOW
-
?
A:
[10-356]
-----------
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
-----
Y
L
T
G
L
R
L
H
-
E
V
-
G
E
R
L
A
I
L
A
V
S
A
E
G
D
Y
R
F
L
A
P
S
-----------
L
----
Y
E
N
--------
V
V
---
N
---
N
F
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
----
E
I
L
E
E
L
G
I
-----
S
K
G
-
R
I
---
L
I
E
----
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
--
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
L
-
S
-
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
-
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
----------------------
Q
E
S
A
F
K
A
V
-
R
E
G
I
K
A
K
D
V
D
-
S
R
A
R
E
V
I
S
K
----
A
G
--------------
Y
G
-
E
Y
----
F
I
H
R
T
G
H
G
L
G
L
--
D
V
H
E
E
P
---
Y
I
G
P
D
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
---------
L
G
---------
G
V
R
I
E
D
D
I
-
V
V
D
E
G
K
G
R
R
L
T
K
-
A
E
R
E
L
I
I
L
-
9
PsiBlast_PDB
85.63
31%
-68
- C1 -
4EGE
22
?
A:
[27-376]
-------------
E
Q
A
G
L
A
G
L
V
I
T
P
G
Y
----
D
L
R
-----
Y
L
I
G
S
R
-
A
-
D
T
-
F
E
R
L
T
A
L
V
L
P
A
S
G
V
P
T
I
V
L
P
R
-----------
L
---
E
L
A
S
--------
L
K
ESA
A
S
D
L
G
V
C
V
R
D
W
V
D
G
D
D
P
Y
Q
L
V
A
----
V
A
L
G
---
G
-----
A
P
A
-
A
T
---
A
V
T
D
S
M
P
A
L
----
H
L
L
P
L
A
D
A
L
G
V
L
--
P
V
L
A
T
D
V
L
R
Q
L
R
M
V
K
E
A
A
E
V
D
A
L
A
K
A
G
A
A
I
D
R
V
H
A
R
V
P
A
F
L
V
P
G
R
T
E
A
Q
V
A
A
D
I
A
E
A
I
V
A
E
-
G
H
S
A
V
A
F
-
V
I
V
G
S
G
P
H
G
A
D
P
H
H
G
Y
---
S
D
R
K
L
Q
V
G
D
I
V
V
V
D
I
G
G
T
Y
E
P
G
Y
Y
S
D
S
T
R
T
Y
S
I
-
G
D
P
S
P
D
V
A
Q
Q
Y
S
A
L
Q
R
A
----------------------
Q
R
A
A
V
D
A
V
-
R
P
G
V
T
A
A
Q
V
D
-
A
A
A
R
D
V
L
A
D
----
A
G
--------------
L
A
-
E
Y
----
F
V
H
R
T
G
H
G
I
G
L
--
C
V
H
E
E
P
---
Y
I
V
A
G
N
E
L
P
L
V
A
G
M
A
F
S
I
E
P
G
I
Y
F
P
G
---------
R
W
---------
G
A
R
I
E
D
I
V
-
V
V
T
E
N
G
A
L
S
V
N
N
-
R
P
H
E
L
M
V
V
-
81
HHSearch
72.98
33%
-79
* C1 *
2V3Z
3
AMPP_ECOLI
A:
[160-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
----------------------
L
E
T
S
L
R
L
Y
-
R
P
G
T
S
I
L
E
V
T
-
G
E
V
V
R
I
M
V
S
G
L
V
K
L
G
ILKG
D
V
D
E
L
I
A
QNA
H
R
-
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
A
P
G
L
Y
I
A
P
DAEVPEQYR
G
I
---------
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
A
S
V
V
K
K
P
E
E
I
E
13
PsiBlast_PDB
67.64
31%
-76
- C1 -
1WL6
6
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
19
PsiBlast_PDB
67.58
31%
-76
- C1 -
1A16
4
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
14
PsiBlast_PDB
67.05
31%
-76
- C1 -
1WLR
3
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
27
PsiBlast_CBE
66.74
31%
-75
- C1 -
2BN7
7
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
18
PsiBlast_PDB
66.22
31%
-75
- C1 -
2BHD
5
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
12
PsiBlast_PDB
65.51
31%
-75
- C1 -
1N51
3
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
20
PsiBlast_PDB
65.31
31%
-76
- C1 -
2BH3
7
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
15
PsiBlast_PDB
64.86
31%
-74
- C1 -
2BHA
3
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
16
PsiBlast_PDB
64.70
31%
-74
- C1 -
2BHB
6
AMPP_ECOLI
A:
[156-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
P
A
T
M
I
--
D
W
--
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
H
-
G
A
R
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
-
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
E
T
S
L
R
L
YRPGTS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
-
K
L
G
I
L
K
G
D
V
D
E
L
I
A
Q
N
A
H
R
------------------------
P
F
----
F
M
H
G
L
S
H
W
L
G
L
--
D
V
H
D
V
G
---
V
Y
G
Q
D
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
P
---------
D
A
EVPEQYRG
I
G
I
R
I
E
D
D
I
-
V
I
T
E
T
G
N
E
N
L
T
-----------
47
PsiBlast_CBE
49.04
31%
-61
- C1 -
3CTZ
5
XPP1_HUMAN
A:
[368-542]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
R
R
Q
Q
A
-
D
F
V
D
L
S
F
P
T
I
S
S
T
G
P
T
G
A
I
I
H
Y
A
P
V
PE
T
N
R
T
L
S
L
D
E
V
Y
L
I
D
S
G
A
Q
Y
K
-
D
G
T
T
D
V
T
R
T
M
H
F
-
E
T
P
T
A
Y
E
K
E
C
F
T
Y
V
L
K
G
----------------------
H
I
A
V
S
A
A
V
F
P
T
G
T
K
G
H
L
L
D
-
S
F
A
R
S
A
L
W
D
----
S
G
--------------
L
--
D
Y
----
L
-
H
G
T
G
H
G
V
G
S
FL
N
V
H
E
G
P
C
G
I
S
Y
K
T
F
S
D
E
P
L
E
A
G
M
I
V
T
D
E
P
G
Y
Y
E
D
G
---------
A
F
---------
G
I
R
I
E
N
V
V
-
L
V
--------------------