@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1961: (2016-03-30 )
LPNEVYDVTIIGGGPIGLFSAFYSGLRSMKTKIIDAEPAVGGKVRYFFPEKIIRDIGGIPAITGENLVANLKQQAETFHPTIVCSERVVDVTKLADGTFQLTSHNGSIHFSKTIVIATGSGTFEVNKLEALHAEDFPFAIHYDVKNIEQFRDKVVVVSGGGNSAIDWAQTLEPIAKKVHLIYRGEDFKAHEESVRELKNSRVEIHIHHEISELIGTNNQLTEITVCCNQTQTTKTIETEALFINHGVKVDLGTMAEWGFKQADFGIVVDDEMKTTVPGIFACGDSATYPRKIRIIAAGLHEGPIAINSAKKYLEPTAADEAMISTHHESFIG
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30......----.----..----40........50........60.-........70........80........90..--..--.--.--..100.---......110.......120....-.-..130...----.--.-..-140-....---.---.-.--------150.......160.......170.......180.......190--.---.-.-...-.-.-.-200--.----........210.......--220.......230.......240--.......250.....----...260.-..-....270........280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPNE
V
Y
D
V
T
I
IGGG
P
I
G
L
F
S
A
F
Y
S
G
L
R
S
M
K
-
T
K
I
IDA----E----PA----VGG
K
V
R
Y
F
F
P
E
K
I
I
R
D
IGGIP-A-ITG
E
N
L
V
A
N
L
K
Q
Q
A
E
TFH
P
T
I
V
CSERVV
D
V
T
K--LA--D--
G
--
T
F
Q
L
TS---HNG
S
I
H
F
S
K
T
I
V
I
A
TGSG
T
F
E
V
N
-
K
-
L
E
A
LHAED----F--
P
-
F
A
-
I
H
Y-D
V
K
N
---
I
---
E
-
Q
--------FRD
K
V
V
V
V
SGGGNSA
I
D
W
A
Q
T
L
E
P
I
A
K
K
V
H
L
I
Y
RGEDF
K
A
H
----
E
---
E
-
S
-
V
R
E
-
L
-K-N-S----
R
----
V
E
I
H
I
H
H
E
I
S
E
L
IGTNN
Q
--
L
T
E
I
T
V
CCNQTQT
T
K
T
I
E
T
E
A
L
F
--INHG
V
K
V
D
-
L
G
T
M
A
E
----WGFKQAD-
F
G
-
I
V
VDD-EMKTTV
P
G
I
F
ACGDSATY
P
R
K
I
R
I
I
A
AGLHEG
P
I
AI
N
S
A
K
K
YLEPTAA
D
E
A
M
I
S
T
H
H
E
SFIG
62
HHSearch
97.28
41%
-102
- C3 -
3LZW
3
FENR2_BACSU
A:
[4-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
----
L
----
P
Q
----
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
--
Q
A
--
D
--
G
--
V
F
K
L
V
T
---
N
-
E
E
T
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
-
L
E
L
E
N
A
E
Q
----
Y
--
E
G
K
N
-
L
H
Y
-
F
V
D
D
---
L
---
Q
-
K
--------
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
---
H
-
S
-
V
E
N
-
L
-
H
-
A
-
S
----
K
----
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
-
D
K
--
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
--
V
N
Y
G
F
V
S
S
-
L
G
P
I
K
N
----
W
G
L
D
I
E
K
-
N
S
-
I
V
V
K
S
-
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
------
1
PsiBlast_PDB
95.79
40%
-102
- C3 -
3LZW
3
FENR2_BACSU
A:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
----
L
----
P
Q
----
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
--
Q
A
--
D
--
G
--
V
F
K
L
V
T
----
N
E
E
T
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
-
L
E
L
E
N
A
E
Q
----
Y
--
E
-
G
K
N
L
H
Y
-
F
V
D
D
---
L
---
Q
-
K
--------
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
---
H
-
S
-
V
E
N
-
L
-
H
-
A
-
S
----
K
----
V
N
V
L
T
P
F
V
P
A
E
L
I
G
-
E
D
K
--
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
--
V
N
Y
G
F
V
S
S
-
L
G
P
I
K
N
----
W
G
L
D
I
E
K
-
N
S
-
I
V
V
K
S
-
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
-------
21
PsiBlast_CBE
95.65
40%
-102
- C3 -
3LZX
4
FENR2_BACSU
B:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
----
L
----
P
Q
----
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
--
Q
A
--
D
--
G
--
V
F
K
L
V
T
----
N
E
E
T
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
-
L
E
L
E
N
A
E
Q
----
Y
--
E
-
G
K
N
L
H
Y
-
F
V
D
D
---
L
---
Q
-
K
--------
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
---
H
-
S
-
V
E
N
-
L
-
H
-
A
-
S
----
K
----
V
N
V
L
T
P
F
V
P
A
E
L
I
G
-
E
D
K
--
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
--
V
N
Y
G
F
V
S
S
-
L
G
P
I
K
N
----
W
G
L
D
I
E
K
-
N
S
-
I
V
V
K
S
-
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
-------
2
PsiBlast_PDB
95.42
40%
-100
- C3 -
3LZX
4
FENR2_BACSU
A:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
----
L
----
P
Q
----
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
C
L
E
Q
A
V
E
S
V
E
K
--
Q
A
--
D
--
G
--
V
F
K
L
V
T
----
N
E
E
T
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
-
L
E
L
E
N
A
E
Q
----
Y
--
E
-
G
K
N
L
H
Y
-
F
V
D
D
---
L
---
Q
-
K
--------
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
---
H
-
S
-
V
E
N
-
L
-
H
-
A
-
S
----
K
----
V
N
V
L
T
P
F
V
P
A
E
L
I
G
-
E
D
K
--
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
I
L
E
I
D
D
L
I
--
V
N
Y
G
F
V
S
S
-
L
G
P
I
K
N
----
W
G
L
D
I
E
K
-
N
S
-
I
V
V
K
S
-
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
-------
22
PsiBlast_CBE
92.96
36%
-97
- C3 -
3AB1
1
FENR_CHLTE
B:
[13-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
----
M
----
P
Q
----
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
V
L
N
E
T
V
T
K
Y
T
K
--
L
D
--
D
--
G
--
T
F
E
T
R
T
---
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
-
K
-
L
P
Q
L
G
N
I
D
----
H
LT
G
-
S
S
-
V
Y
Y
-
A
V
K
S
---
V
---
E
-
D
--------
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
----
G
---
K
-
T
-
A
H
E
-
V
-
E
-
R
-
A
----
R
ANGT
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
--
L
T
R
V
H
L
R
S
S
D
-
G
S
K
W
T
V
E
A
D
R
L
L
--
I
L
I
G
F
K
S
N
-
L
G
P
L
A
R
----
W
D
L
E
L
Y
E
-
N
A
-
L
V
V
D
S
-
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
-----------------
3
PsiBlast_PDB
92.71
36%
-99
- C3 -
3AB1
1
FENR_CHLTE
A:
[13-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
----
M
----
P
Q
----
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
V
L
N
E
T
V
T
K
Y
T
K
--
L
D
--
D
--
G
--
T
F
E
T
R
T
---
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
-
K
-
L
P
Q
L
G
N
I
D
----
H
LT
G
-
S
S
-
V
Y
Y
-
A
V
K
S
---
V
---
E
-
D
--------
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
----
G
---
K
-
T
-
A
H
E
-
V
-
E
-
R
-
A
----
R
A
N
GT
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
--
L
T
R
V
H
L
R
S
S
D
-
G
S
K
W
T
V
E
A
D
R
L
L
--
I
L
I
G
F
K
S
N
-
L
G
P
L
A
R
----
W
D
L
E
L
Y
E
-
N
A
-
L
V
V
D
S
-
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
-----------------
64
HHSearch
90.62
36%
-96
- C3 -
3AB1
1
FENR_CHLTE
A:
[13-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
----
M
----
P
Q
----
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
-
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
V
L
N
E
T
V
T
K
Y
T
K
--
L
D
--
D
--
G
--
T
F
E
T
R
T
---
N
T
G
N
V
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
-
K
L
P
Q
L
G
N
I
D
H
----
L
--
T
G
S
S
-
V
Y
Y
-
A
V
K
S
---
V
---
E
-
D
--------
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
A
H
---
E
-
V
-
E
R
A
-
R
-
A
-
N
-
G
----
T
----
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
--
L
T
R
V
H
L
R
S
S
D
-
G
S
K
W
T
V
E
A
D
R
L
L
--
I
L
I
G
F
K
S
N
-
L
G
P
L
A
R
----
W
D
L
E
L
Y
E
-
N
A
-
L
V
V
D
S
-
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
----------------
4
PsiBlast_PDB
88.63
35%
-104
- C3 -
2ZBW
1
FENR_THET8
A:
[7-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
----
L
----
P
E
----
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
P
V
Y
S
L
G
E
R
A
E
T
L
E
R
--
E
G
--
D
-----
L
F
K
V
T
T
---
S
Q
G
N
A
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
-
R
-
I
G
A
P
G
E
R
E
----
F
--
E
G
R
G
-
V
Y
Y
-
A
V
K
S
---
K
---
A
-
E
--------
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
----
E
---
A
-
S
-
V
K
E
-
L
-
M
-
K
-
A
H
E
E
G
R
----
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
-
D
E
R
--
V
R
W
A
V
V
F
H
N
Q
T
Q
E
E
L
A
L
E
V
D
A
V
L
--
I
L
A
G
Y
I
T
K
-
L
G
P
L
A
N
----
W
G
L
A
L
E
K
-
N
K
-
I
K
V
D
T
-
T
M
A
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
-------------------------------
63
HHSearch
87.54
33%
-87
- C3 -
2ZBW
2
FENR_THET8
A:
[3-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
H
T
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
----
L
----
P
E
----
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
-
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
P
V
Y
S
L
G
E
R
A
E
T
L
E
R
--
E
G
-----
D
--
L
F
K
V
T
T
---
S
Q
G
N
A
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
-
R
-
I
G
A
P
G
E
R
E
----
F
--
E
G
R
G
-
V
Y
Y
-
A
V
K
S
---
K
---
A
-
E
--------
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
E
A
S
V
K
---
E
-
L
-
M
K
A
-
H
-
E
-
E
-
G
----
R
----
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
--
R
W
A
V
V
F
H
N
Q
-
T
Q
E
E
L
A
L
E
V
D
A
V
L
--
I
L
A
G
Y
I
T
K
-
L
G
P
L
A
N
----
W
G
L
A
L
E
K
-
N
K
-
I
K
V
D
T
-
T
M
A
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
E
------
82
Fugue
83.26
23%
-90
- C3 -
1HYU
4
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
----
R
----
F
------
G
G
Q
V
L
---
D
T
V
D
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
AA
T
E
--
G
--
G
--
L
H
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
---
A
K
W
R
-
N
-
M
N
V
P
G
E
D
Q
----
Y
R-
T
-
K
G
-
V
T
Y
C
P
H
C
D
---
G
---
P
-
L
--------
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
---
V
-
L
-
Q
D
K
-
V
-
R
S
L
-
K
----
N
----
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
--
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
--
V
Q
I
G
L
L
P
N
-
T
H
W
L
E
G
----
A
L
E
R
N
R
M
-
G
E
-
I
I
I
D
A
-
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
--
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
-------------
67
HHSearch
82.71
25%
-103
- C3 -
1FL2
5
AHPF_ECOLI
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
----------
R
----
F
G
G
Q
I
L
D
T
V
D
---
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
--
A
A
VE
G
--
G
--
L
H
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
---
K
W
R
-
N
-
M
N
V
P
G
E
D
Q
----
Y
--
R
T
K
G
-
V
T
Y
-
C
P
H
C
---
D
G--
P
-
L
--------
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
---
V
-
L
-
Q
D
K
-
L
-
R
-
S
L
K
----
N
----
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
--
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
--
V
Q
I
G
L
L
P
N
-
T
N
W
L
E
G
-----
A
V
E
R
N
R
M
G
E
-
I
I
I
D
A
-
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
--
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
----------------
76
HHSearch
82.04
24%
-100
- C3 -
1HYU
4
AHPF_SALTY
A:
[209-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
----
R
----------
F
G
G
Q
V
L
D
T
V
D
---
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
--
A
A
TE
G
--
G
--
L
H
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
---
K
W
R
-
N
-
M
N
V
P
G
E
D
Q
----
Y
--
R
T
K
G
-
V
T
Y
-
C
P
H
C
---
D
G--
P
-
L
--------
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
---
V
-
L
-
Q
D
K
-
V
-
R
-
S
L
K
----
N
----
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
--
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
--
V
Q
I
G
L
L
P
N
-
T
H
W
L
E
G
-----
A
L
E
R
N
R
M
G
E
-
I
I
I
D
A
-
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
----------------
20
PsiBlast_PDB
81.53
26%
-97
- C3 -
4YKF
16
?
A:
[211-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
----
R
----------
F
G
G
Q
I
---
L
D
T
V
D
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
--
A
A
VE
G
--
G
--
L
H
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
---------------
V
--
P
-
G
E
-
D
Q
Y
-
R
T
K
G
---
V
---
T
-
Y
CPHCDGPL
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
V
L
Q
D
-
K
-
L
R
S
-
L
-
K
-
N
-----------
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
--
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
--
V
Q
I
G
L
L
P
N
-
T
N
W
L
-
E
----
G
A
V
E
R
N
R
-
M
G
E
I
I
I
D
A
-
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
K
Q
I
I
I
A
T
G
--
E
G
A
K
A
S
L
S
A
F
D
Y
L
-------------------
19
PsiBlast_PDB
80.49
26%
-98
- C3 -
1HYU
4
AHPF_SALTY
A:
[210-515]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
----
R
----------
F
G
G
Q
V
---
L
D
T
V
D
I
E
N
Y
I
S
V
P
-
K
-
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
--
A
A
--
T
EG
G
--
L
H
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
---------------
V
--
P
-
G
E
-
D
Q
Y
-
R
T
K
G
---
V
---
T
-
Y
CPHCDGPL
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
V
L
Q
D
-
K
-
V
R
S
-
L
-
K
-
N
-----------
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
--
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
--
V
Q
I
G
L
L
P
N
-
T
H
W
L
-
E
----
G
A
L
E
R
N
R
-
M
G
E
I
I
I
D
A
-
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
K
Q
I
I
I
A
T
G
--
E
G
A
K
A
S
L
S
A
F
D
Y
L
-------------------
73
HHSearch
80.40
26%
-93
- C3 -
2Q7V
2
?
A:
[5-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
D
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
-
T
L
I
L
E
K
----
G
----
M
-----
P
G
G
Q
I
A
W
S
E
--
E
-
V
E
N
F
P
G
F
P
E
P
-
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
V
E
M
-
D
E
V
Q
G
V
Q
H
--
D
A
--
T
S-
H
PY
P
F
T
V
R
G
---
Y
-
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
---
D
P
R
-
K
-
L
G
I
P
G
E
D
N
----
F
--
W
G
K
G
-
V
S
T
-
C
A
T
C
---
D
G--
F
-
F
--------
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
---
V
---
A
-
Q
-
A
R
A
-
F
-
A
-
N
-
P
----
K
----
M
K
F
I
W
D
T
A
V
E
E
I
Q
G
A
-
D
S
--
V
S
G
V
K
L
R
N
L
K
T
G
E
V
S
E
L
A
T
D
G
V
F
--
I
F
I
G
H
V
P
N
-
T
A
F
V
K
D
-----
T
V
S
L
R
D
D
G
Y
-
V
D
V
R
D
-
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
Y
--
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
-----------------
66
HHSearch
79.61
25%
-108
* C3 *
3R9U
2
?
A:
[1-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
A
M
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
N
V
V
M
F
E
K
----
G
----
M
-----
P
G
G
Q
I
T
S
S
S
---
E
I
E
N
Y
P
G
V
A
-
Q
V
M
D
G
I
S
F
M
A
P
W
S
E
Q
C
M
R
F
G
L
K
H
-
E
M
V
G
V
E
Q
I
L
K
--
N
S
--
D
--
G
--
S
F
T
I
K
L
---
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
---
A
P
K
-
K
-
A
G
F
K
G
E
D
E
----
F
--
F
G
K
G
-
V
S
T
-
C
A
T
C
---
D
---
G
F
F
--------
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
----
P
---
S
-
T
-
V
E
K
V
K
-
K
-
N
-
E
----
K
----
I
E
L
I
T
S
A
S
V
D
E
V
Y
G
D
K
M
G
--
V
A
G
V
K
V
K
L
K
-
D
G
S
I
R
D
L
N
V
P
G
I
F
--
T
F
V
G
L
N
V
R
-
N
E
I
L
K
Q
DDSK
F
L
C
N
M
E
E
G
G
Q
-
V
S
V
D
L
-
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
K
D
A
--
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
----------------
71
HHSearch
78.91
25%
-89
- C3 -
1VDC
2
TRXB1_ARATH
A:
[4-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
H
N
T
R
L
C
I
V
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
-
P
L
L
F
E
G
----
W
MAND
I
A
----
P
G
G
Q
L
T
T
T
T
D
---
V
E
N
F
P
G
F
P
E
G
-
I
L
G
V
E
L
T
D
K
F
R
K
Q
S
E
R
F
G
T
T
I
-
F
T
E
T
V
T
K
V
D
F
--
S
S
-----
K
--
P
F
K
L
F
T
---
D
-
S
K
A
I
L
A
D
A
V
I
L
A
I
G
A
---
V
A
K
-
R
-
L
S
F
V
G
S
G
E
VLGG
F
--
W
N
R
G
-
I
S
A
-
C
A
V
C
DGA
A
---
P
-
I
--------
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
M
E
E
A
N
F
L
T
K
Y
G
S
K
V
Y
I
I
H
R
R
D
A
F
R
A
S
----
K
---
I
-
M
Q
Q
R
A
-
L
-
S
-
N
-
P
----
K
----
I
D
V
I
W
N
S
S
V
V
E
A
Y
G
D
G
E
R
DV
L
G
G
L
K
V
K
N
V
V
T
G
D
V
S
D
L
K
V
S
G
L
F
--
F
A
I
G
H
E
P
A
-
T
K
F
L
D
G
-----
G
V
E
L
D
S
D
G
Y
-
V
V
T
K
P
G
T
T
Q
T
S
V
P
G
V
F
A
A
G
D
V
Q
D
K
K
Y
--
R
Q
A
I
T
A
A
G
T
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
-----------------
8
PsiBlast_PDB
78.73
28%
-78
- C3 -
4CCQ
6
?
A:
[2-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
-
P
V
M
Y
E
G
FMAG
G
----
V
A
----
A
G
G
Q
L
T
---
T
T
T
I
I
E
N
F
P
G
F
P
N
G
-
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
--
T
E
T
I
D
H
V
D
--
F
S
--
T
--
Q
--
P
F
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
-
G
E
D
K
Y
W
Q
N
----
G
--
V
-
S
A
-
C
A
I
-
C
D
G
A
---
V
---
P
-
I
--------
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
----
K
---
T
M
Q
-
E
R
V
-
L
-
N
-
H
-
P
----
K
----
I
E
V
I
W
N
S
E
L
V
E
L
E
G
D
G
D
L
--
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
G
Q
V
--------
K
T
A
D
-
D
G
-
Y
I
L
T
E
-
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
Y
R
Q
A
I
V
A
A
G
--
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
------------------
7
PsiBlast_PDB
78.03
28%
-80
- C3 -
4CBQ
9
?
A:
[3-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
H
D
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
-
P
V
M
Y
E
G
FMAG
G
----
V
A
----
A
G
G
Q
L
T
---
T
T
T
I
I
E
N
F
P
G
F
P
N
G
-
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
I
I
--
T
E
T
I
D
H
V
D
--
F
S
--
T
--
Q
--
P
F
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
-
G
E
D
K
Y
W
Q
N
----
G
--
V
-
S
A
-
C
A
I
-
C
D
G
A
---
V
---
P
-
I
--------
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
----
K
---
T
M
Q
-
E
R
V
-
L
-
N
-
H
-
P
----
K
----
I
E
V
I
W
N
S
E
L
V
E
L
E
G
D
G
D
L
--
L
N
G
A
K
I
H
N
L
V
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
G
Q
V
--------
K
T
A
D
-
D
G
-
Y
I
L
T
E
-
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
Y
R
Q
A
I
V
A
A
G
--
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
------------------
70
HHSearch
77.99
25%
-94
- C3 -
3ITJ
3
TRXB1_YEAST
A:
[21-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
N
K
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
-
P
I
L
Y
E
G
----
M
----
M
A
NGIA
A
G
G
Q
L
T
T
T
T
---
E
I
E
N
F
P
G
F
P
D
G
-
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
I
-
I
T
E
T
V
S
K
V
D
L
--
S
S
-----
K
--
P
F
K
L
W
T
EFN
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
---
S
A
K
-
R
-
M
H
L
P
G
E
E
T
----
Y
--
W
Q
K
G
-
I
S
A
-
C
A
V
C
---
D
GAV
P
-
I
--------
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
----
T
---
I
-
M
-
Q
K
R
-
A
E
K
-
N
-
E
----
K
----
I
E
I
L
Y
N
T
V
A
L
E
A
K
G
D
G
K
L
--
L
N
A
L
R
I
K
N
T
K
K
N
E
E
T
D
L
P
V
S
G
L
F
--
Y
A
I
G
H
T
P
A
-
T
K
I
V
A
G
-----
Q
V
D
T
D
E
A
G
Y
-
I
K
T
V
P
G
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
Y
--
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
-----------------