@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2547: (2016-04-04 )
VEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYNISVKKVLVRDLEKNRRYETKGFELTTNPSDVLDDPEIAVVVEVMGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVAQANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVNGTTNFMLTKMTTEKKSYEDVLAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIEVAYQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGPGAGELPTATSVVSDLITVAKNSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKTGTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTSQAQLEQAIARVKDEPEMQMLAKYSVVEG
Atome Classification :
(20 SA)
.........10........20........30....-----------....40......---------..50.--------.----.------...-.-------.60..-......70---.........80..-......---90........100.....-..110........120.........130.......140......-.150.......160.......170---.......180.......190.......200.......210.......220........230...---------------------....240.......250.......260.......270.......280.......290........300.......310.......320.-....-.--.330...-.---------...340.......350.......360.......370.......380-.......390.......400.......410.......420......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VE
A
K
L
Q
V
G
V
L
G
FG
T
V
G
S
G
V
I
H
I
L
E
E
H
Q
E
K
I
S
Q
VTG-----------YN
I
S
V
K
K
V
L
V
R
D
---------
L
E
KNR--------R----Y------ETK-G-------
F
E
LTT-N
P
S
DVLD----DP
E
I
A
V
V
V
E
V
M
G
S
-
I
T
T
A
R
E
---
Y
I
L
Q
A
L
KAG
K
H
V
V
TANK
D
-
L
I
A
-LHGD
E
L
V
A
V
A
--QANNC
D
L
F
Y
EASVAG
G
I
P
I
L
R
T
I
V
N
S
L
A
-
A
D
K
I
Q
K
V
M
G
I
VNGTT
N
F
M
L
T
KMTT---EK
K
S
Y
E
D
V
L
A
E
A
Q
ALGFAESDPTNDV
D
G
I
D
A
A
R
K
M
V
I
M
T
R
L
AFGMNVN-LDNVETNGIRGI
S
P
E
---------------------
D
I
E
V
A
YQLG
Y
K
I
K
L
V
G
TAEETN
G
T
V
N
V
NVG
P
V
LLPKAHPLA
G
V
NYEN
N
A
V
F
V
TGAA-VGE
T
M
F
YGPGAGELP
T
A
T
S
V
V
S
D
L
I
T
V
AKNSR-LGTN-G--NAFNSYK-H---------ETKHT
P
K
E
Q
V
F
S
K
Y
Y
L
R
L
T
MDDKT
G
T
F
L
K
L
T
Q
I
F
A
EAGV
G
F
D
K
I
L
Q-QPYDD
F
T
A
T
V
V
I
V
THST
S
Q
A
Q
L
E
Q
A
I
A
RVKD
E
P
E
M
Q
M
L
A
K
YSVVEG
28
HHSearch
98.22
40%
-97
- C4 -
3MTJ
3
?
A:
[8-440]
-
M
K
P
I
H
V
G
L
L
G
L
G
T
V
G
G
G
T
L
T
V
L
R
R
N
A
E
E
I
T
R
R
A
G
-----------
R
E
I
R
V
V
R
A
A
V
R
N
---------
L
D
K
A
E
--------
A
-----------
L
A
G
-
G
-------
L
P
L
T
T
-
N
P
F
D
V
V
D
----
D
P
E
I
D
I
V
V
E
L
I
G
G
-
L
E
P
A
R
E
---
L
V
M
Q
A
I
A
N
G
K
H
V
V
T
A
N
K
H
-
L
V
A
-
K
Y
G
N
E
I
F
A
A
A
--
Q
A
K
G
V
M
V
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
T
-
A
N
R
I
E
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
M
R
D
---
K
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
L
S
A
I
A
F
G
I
P
M
Q
-
F
E
R
A
Y
T
E
G
I
S
Q
L
T
R
E
---------------------
D
V
R
Y
A
E
E
L
G
Y
R
I
K
L
L
G
I
A
R
R
A
E
N
G
I
E
L
R
V
H
P
T
L
I
P
E
R
R
L
I
A
N
V
D
G
A
M
N
A
V
L
V
K
G
D
A
-
V
G
P
T
L
Y
Y
G
A
G
A
G
S
E
P
T
A
S
A
V
V
A
D
L
V
D
V
T
R
L
H
T
A
D
P
H
H
R
V
PH
L
A
F
Q
P
D
Q
L
A
---------
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
L
R
A
F
-
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
-
K
E
----
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
A
L
D
A
V
A
G
K
V
M
R
I
R
L
E
D
51
Fugue
94.03
41%
-96
- C4 -
4PG7
9
?
A:
[20-446]
H
M
K
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
-----------
K
D
I
V
I
K
H
I
L
V
R
D
---------
K
S
K
K
R
--------
P
----
L
------
N
I
S
-
Q
-------
Y
H
L
T
E
-
D
V
N
E
I
L
N
----
D
D
S
L
D
I
I
V
E
V
M
G
G
-
I
E
P
T
V
D
---
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
-
L
L
A
-
V
H
L
K
L
L
E
D
L
A
--
E
E
N
G
V
A
L
K
F
E
A
S
V
A
G
G
-------------
P
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
---
E
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
D
A
-
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
L
F
-----------
F
E
S
T
L
P
P
-
H
---------
F
E
L
K
T
D
K
T
R
E
M
E
K
S
N
F
F
V
V
V
N
H
V
K
G
S
I
E
N
F
E
N
E
L
K
A
I
L
P
F
H
R
S
L
R
V
-
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
-------
G
L
E
S
S
P
E
E
L
I
T
K
H
G
Y
E
V
D
K
V
Y
P
V
E
G
V
3
PsiBlast_PDB
88.94
40%
-95
- C4 -
3MTJ
3
?
A:
[34-424]
---------------------------
E
E
I
T
R
R
A
G
-----------
R
E
I
R
V
V
R
A
A
V
R
N
---------
L
D
K
A
E
--------
A
----
L
-------
A
G
-
G
-------
L
P
L
T
T
-
N
P
F
D
V
V
D
----
D
P
E
I
D
I
V
V
E
L
I
G
G
-
L
E
P
A
R
E
---
L
V
M
Q
A
I
A
N
G
K
H
V
V
T
A
N
K
H
-
L
V
A
-
K
Y
G
N
E
I
F
A
A
A
--
Q
A
K
G
V
M
V
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
T
-
A
N
R
I
E
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
M
R
D
---
K
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
L
S
A
I
A
F
G
I
P
M
Q
-
F
E
R
A
Y
T
E
G
I
S
Q
L
T
R
E
---------------------
D
V
R
Y
A
E
E
L
G
Y
R
I
K
L
L
G
I
A
R
R
A
E
N
G
I
E
L
R
V
H
P
T
L
I
P
E
R
R
L
I
A
N
V
D
G
A
M
N
A
V
L
V
K
G
D
A
-
V
G
P
T
L
Y
Y
G
A
G
A
G
S
E
P
T
A
S
A
V
V
A
D
L
V
D
V
---
T
R
-
L
H
T
--
A
--
D
P
H
H
R
V
P
-
H
LAFQPDQLA
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
L
R
A
F
-
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
K-----
E
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
----------------
21
PsiBlast_CBE
88.14
50%
-104
- C4 -
4PG8
10
?
B:
[23-364]
---
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
-----------
K
D
I
V
I
K
H
I
L
V
R
D
---------
K
S
K
K
R
--------
P
----
L
------
N
I
S
-
Q
-------
Y
H
L
T
E
-
D
V
N
E
I
L
N
----
D
D
S
L
D
I
I
V
E
V
M
G
G
-
I
E
P
T
V
D
---
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
-
L
L
A
-
V
H
L
K
L
L
E
D
L
A
--
E
E
N
G
V
A
L
K
F
E
A
S
V
A
--
I
P
I
V
N
----------
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
---
E
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
---
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.63
50%
-103
- C4 -
4PG4
11
?
B:
[23-370]
---
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
-----------
K
D
I
V
I
K
H
I
L
V
R
D
---------
K
S
K
K
R
--------
P
-----------
N
I
S
-
Q
-------
Y
H
L
T
E
-
D
V
N
E
I
L
N
----
D
D
S
L
D
I
I
V
E
V
M
G
G
-
I
E
P
T
V
D
---
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
-
L
L
A
-
V
H
L
K
L
L
E
D
L
A
--
E
E
N
G
V
A
L
K
F
E
A
S
V
A
G
G
I
P
I
V
N
----------
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
---
E
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
---
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
----------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.97
50%
-101
- C4 -
4PG6
11
?
A:
[23-355]
---
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
-----------
K
D
I
V
I
K
H
I
L
V
R
D
---------
K
S
K
K
R
--------
P
----
L
------
N
I
S
-
Q
-------
Y
H
L
T
E
-
D
V
N
E
I
L
N
----
D
D
S
L
D
I
I
V
E
V
M
G
G
-
I
E
P
T
V
D
---
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
-
L
L
A
-
V
H
L
K
L
L
E
D
L
A
--
E
E
N
G
V
A
L
K
F
E
A
-------------------
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
---
E
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
D
A
-
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.59
50%
-98
- C4 -
4PG4
12
?
A:
[23-354]
---
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
N
-----------
K
D
I
V
I
K
H
I
L
V
R
D
---------
K
S
K
K
R
--------
P
----
L
------
N
I
S
-
Q
-------
Y
H
L
T
E
-
D
V
N
E
I
L
N
----
D
D
S
L
D
I
I
V
E
V
M
G
G
-
I
E
P
T
V
D
---
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
-
L
L
A
-
V
H
L
K
L
L
E
D
L
A
--
E
E
N
G
V
A
L
K
F
E
A
-------------------
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
---
E
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
-
L
N
D
V
K
R
R
G
I
S
G
V
T
L
T
---------------------
D
I
N
V
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
D
A
-
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
----------------------------------------------------------------------------------------------------------------------------
50
Fugue
81.18
33%
-83
- C4 -
2EJW
3
?
A:
[1-331]
-
M
E
A
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
A
F
-
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
----
I
------
P
Q
E
-
L
-------
L
R
------
A
E
P
F
D
----
L
L
E
A
D
L
V
V
E
A
M
G
G
-
V
E
A
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
R
-
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
R
A
R
--
G
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
V
T
G
P
G
A
G
G
G
A
T
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
-
G
H
L
P
-
A
--
P
R
A
R
P
P
L
-
E
---------
E
G
S
P
W
P
G
V
-------------------------------------------------------------------------------------
33
HHSearch
80.73
36%
-91
- C4 -
2EJW
3
?
A:
[1-312]
-
M
E
A
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
-
A
F
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
-----------
I
-
P
-
Q
--------
E
L
L
R
-
A
-
E
-
P
F
D
----
L
L
E
A
D
L
V
V
E
A
M
G
G
V
E
A
-
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
E
T
L
R
--
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
V
T
G
P
G
A
G
G
G
A
T
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
-
G
H
---------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.44
35%
-101
- C4 -
2EJW
3
?
A:
[4-283]
----
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
A
F
-
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
----
I
------
P
Q
E
----------
L
L
R
A
-
E
P
F
D
L
L
-------
E
A
D
L
V
V
E
A
M
G
G
-
V
E
A
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
-
S
F
L
E
T
L
R
-
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
--
R
A
R
G
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.22
35%
-102
- C4 -
2EJW
3
?
B:
[4-283]
----
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
A
F
-
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
----
I
------
P
Q
E
----------
L
L
R
A
-
E
P
F
D
L
L
-------
E
A
D
L
V
V
E
A
M
G
G
-
V
E
A
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
-
S
F
L
E
T
L
R
-
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
--
R
A
R
G
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.78
35%
-103
- C4 -
2EJW
4
?
E:
[4-283]
----
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
A
F
-
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
----
I
------
P
Q
E
----------
L
L
R
A
-
E
P
F
D
L
L
-------
E
A
D
L
V
V
E
A
M
G
G
-
V
E
A
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
-
S
F
L
E
T
L
R
-
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
--
R
A
R
G
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.44
35%
-95
- C4 -
2EJW
3
?
F:
[4-283]
----
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
A
E
E
L
S
A
F
-
G
-----------
V
V
P
R
F
L
G
V
L
V
R
D
---------
P
R
K
P
R
--------
A
----
I
------
P
Q
E
----------
L
L
R
A
-
E
P
F
D
L
L
-------
E
A
D
L
V
V
E
A
M
G
G
-
V
E
A
P
L
R
---
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
-
L
L
A
-
E
A
W
E
S
L
R
P
F
A
--
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
-
S
F
L
E
T
L
R
-
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
----
K
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
-
F
A
E
V
E
A
Q
G
I
A
R
L
T
P
E
---------------------
V
L
Q
K
A
E
A
R
G
E
R
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
R
R
L
P
Q
D
H
P
L
A
--
R
A
R
G
N
A
L
W
V
R
A
R
P
-
L
G
E
A
F
---------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.21
35%
-95
* C4 *
3DO5
3
?
A:
[2-325]
---
M
I
K
I
A
I
V
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
R
E
E
I
E
K
A
-
I
-----------
G
E
F
K
V
T
A
V
A
D
S
K
---------
S
S
I
S
G
--------
D
FS
L
V
E
A
L
R
M
K
R
E
T
G
-
M
-------
L
R
D
D
A
-
K
A
I
E
V
V
R
----
S
A
D
Y
D
V
L
I
E
A
S
V
T
R-
E
-
G
V
N
---
Y
I
R
E
A
L
K
R
G
K
H
V
V
T
S
N
K
G
-
P
L
V
-
A
E
F
H
G
L
M
S
L
A
--
E
R
N
G
V
R
L
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
A
-
L
C
E
I
E
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
M
E
E
---
E
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
I
A
N
T
-
I
G
V
K
A
S
-
Y
E
D
V
E
V
T
G
I
T
Q
I
T
P
E
---------------------
A
F
Q
V
A
A
E
K
G
Y
T
I
R
L
I
A
E
V
S
R
----
E
K
L
K
V
S
P
R
L
V
P
F
H
H
P
L
A
-
I
K
G
T
M
N
A
A
M
F
K
T
D
T
-
A
G
S
I
F
V
A
G
R
G
A
G
K
E
E
T
A
S
A
I
L
S
D
L
Y
E
I
Y
A
G
--------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.97
36%
-96
- C4 -
3DO5
3
?
A:
[3-325]
----
I
K
I
A
I
V
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
R
E
E
I
E
K
A
I
G
EFKVT
A
V
A
D
S
K
S
S
I
S
G
D
F
S
L
V
E
A
---------
L
R
M
K
R
--------------------
E
T
G
-
M
-------
L
R
D
D
A
-
K
A
I
E
V
V
R
----
S
A
D
Y
D
V
L
I
E
A
S
V
T
-
R
----
E
G
V
N
Y
I
R
E
A
L
K
R
G
K
H
V
V
T
S
N
K
G
P
L
V
A
E
F
H
G
--
L
M
S
L
A
--
E
R
N
G
V
R
L
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
A
-
L
C
E
I
E
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
M
E
E
---
E
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
I
A
N
-
T
I
G
V
K
A
S
-
Y
E
D
V
E
V
T
G
I
T
Q
I
T
P
E
---------------------
A
F
Q
V
A
A
E
K
G
Y
T
I
R
L
I
A
E
V
S
R
E
----
K
L
K
V
S
P
R
L
V
P
F
H
H
P
L
A
I
K
G
T
M
N
A
A
M
F
K
T
D
T
A
--
G
S
I
F
V
A
G
R
G
A
G
K
E
E
T
A
S
A
I
L
S
D
L
Y
E
I
Y
A
G
--------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.85
31%
-89
- C4 -
4XB1
5
?
B:
[18-325]
---
K
V
N
I
S
I
F
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
K
----
S
R
I
F
G
-----------
V
E
L
N
V
I
S
I
T
D
R
S
GTIWGDFDL
L
E
A
K
E
--------
V
----
K
------
E
S
T
-
G
KLSNIGD
Y
E
V
Y
N
F
S
P
Q
E
L
V
E
----
E
V
K
P
N
I
L
V
D
V
-
S
S
-
W
D
E
A
H
E
---
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
-
P
I
A
-
N
Y
Y
D
E
L
M
N
L
A
--
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
-
S
---
E
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
---
E
E
E
E
R
L
G
I
R
E
V
------------------------------
R
D
A
R
N
V
R
L
V
--
A
Q
V
S
K
G
K
I
S
V
K
--
P
R
K
L
S
S
D
N
P
L
L
V
E
G
V
Q
N
A
A
V
I
R
T
N
-
N
-
L
G
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
-------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.26
31%
-90
- C4 -
4XB2
3
?
B:
[18-325]
---
K
V
N
I
S
I
F
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
K
----
S
R
I
F
G
-----------
V
E
L
N
V
I
S
I
T
D
R
S
GTIWGDFDL
L
E
A
K
E
--------
V
----
A
------
E
S
T
-
G
KLSNIGD
Y
E
V
Y
N
F
S
P
Q
E
L
V
E
----
E
V
K
P
N
I
L
V
D
V
-
S
S
-
W
D
E
A
H
E
---
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
-
P
I
A
-
N
Y
Y
D
E
L
M
N
L
A
--
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
-
S
---
E
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
---
E
E
E
E
R
L
G
I
R
E
V
------------------------------
R
D
A
R
N
V
R
L
V
--
A
Q
V
S
K
G
K
I
S
V
K
--
P
R
K
L
S
S
D
N
P
L
L
V
E
G
V
Q
N
A
A
V
I
R
T
N
-
N
-
L
G
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
-------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.08
31%
-88
- C4 -
4XB2
3
?
A:
[18-325]
---
K
V
N
I
S
I
F
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
K
----
S
R
I
F
G
-----------
V
E
L
N
V
I
S
I
T
D
R
S
G
T
I
W
GDFD
L
L
E
A
K
E
--------
V
----
A
------
E
S
T
-
G
KLSNIGD
Y
E
V
Y
N
F
S
P
Q
E
L
V
E
----
E
V
K
P
N
I
L
V
D
V
-
S
S
-
W
D
E
A
H
E
---
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
-
P
I
A
-
N
Y
Y
D
E
L
M
N
L
A
--
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
-
S
---
E
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
---
E
E
E
E
R
L
G
I
R
E
V
------------------------------
R
D
A
R
N
V
R
L
V
--
A
Q
V
S
K
G
K
I
S
V
K
--
P
R
K
L
S
S
D
N
P
L
L
V
E
G
V
Q
N
A
A
V
I
R
T
N
-
N
-
L
G
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
-------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.37
31%
-89
- C4 -
4XB1
4
?
A:
[18-325]
---
K
V
N
I
S
I
F
G
F
G
T
V
G
R
A
L
A
E
I
I
A
E
K
----
S
R
I
F
G
-----------
V
E
L
N
V
I
S
I
T
D
R
S
G
T
I
W
G
DFD
L
L
E
A
K
E
--------
V
----
K
------
E
S
T
-
G
KLSNIGD
Y
E
V
Y
N
F
S
P
Q
E
L
V
E
----
E
V
K
P
N
I
L
V
D
V
-
S
S
-
W
D
E
A
H
E
---
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
-
P
I
A
-
N
Y
Y
D
E
L
M
N
L
A
--
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
L
-
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
-
S
---
E
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
---
E
E
E
E
R
L
G
I
R
E
V
------------------------------
R
D
A
R
N
V
R
L
V
--
A
Q
V
S
K
G
K
I
S
V
K
--
P
R
K
L
S
S
D
N
P
L
L
V
E
G
V
Q
N
A
A
V
I
R
T
N
-
N
-
L
G
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
-------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
72.17
24%
-80
- C4 -
1EBF
2
DHOM_YEAST
A:
[2-357]
-
T
K
V
V
N
V
A
V
I
G
A
G
V
V
G
S
A
F
L
D
Q
L
L
A
M
K
S
T
I
----
T
-----------
Y
N
L
V
L
L
A
E
A
E
R
S
---------
L
I
S
K
D
FSPLNVGS
D
W
K
--
A
------
A
L
A
A
S
-------
T
T
K
T
L
-
P
L
D
D
L
I
A
H
L
K
T
S
P
K
P
V
I
L
V
D
N
T
S
S
-
A
Y
-
I
A
G
---
F
Y
T
K
F
V
E
N
G
I
S
I
A
T
P
N
K
K
-
A
F
S
-
S
D
L
A
T
W
K
A
L
F
SN
K
P
T
N
G
F
V
Y
H
E
A
T
V
G
A
G
L
P
I
I
S
F
L
R
E
I
I
Q
T
G
D
E
V
E
K
I
E
G
I
F
S
G
T
L
S
Y
I
F
N
E
F
S
T
SQA
N
D
V
K
F
S
D
V
V
K
V
A
K
K
L
G
Y
T
E
P
D
P
R
D
D
L
N
G
L
D
V
A
R
K
V
T
I
V
G
R
I
S
-
G
V
E
V
E
S
P
T
S
F
P
V
Q
S
L
I
P
K
P
L
E
SVKS
A
D
E
F
L
E
K
L
S
DYD
K
D
L
T
Q
L
K
K
E
A
A
T
E
N
K
V
L
R
F
I
G
K
V
D
V
A
--
T
K
S
V
S
V
G
I
E
K
Y
D
Y
S
H
P
F
A
S
L
K
G
S
D
N
V
I
S
I
K
T
K
R
Y
T
N
P
V
V
I
Q
G
A
G
A
G
A
A
V
T
A
A
G
V
L
G
D
V
I
K
I
A
Q
R
--------------------------------------------------------------------------------------------------------------------------