@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0149: (2015-11-28 )
MRIFEKAPAKLNLGLDIKGRCDDGYHELAMIMVSIDLNDYVTISELKEDCIVIDSDSSKMPLNNDNDVFKAADIIKNQYGINKGVHIRLEKSIPVCAGLGGGSTDAAATIRALNRLWNLQMDYDEMVAIGFKIGSDVPYCLGGGCSLVLGKGEIVKPLPTLRPCWIVLVKPDFGISTKSIFRDIDCKSISRVDIDLLKSAILSSDYQLMVKSMGNSLEDITITKNPVISTIKERMLNSGADVALMTGSGPTVFSMCSTEKKADRVFNSMKGFCKEVYKVRLLR
Atome Classification :
(20 SA)
........---.10-........20........30.....-...40........50---......-..60-..-......70....------....80-----.........90........100.......110.......120.......130..---------.---------..---------..140.......150.-----.....-.160.......170.......180------...--------.-...190-.------......-.200.......210..--.--.-..-.220....---...230.......240-........250--.......-260......----.--270.........280.--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRIFEKAP---
A
K
L
-
N
LG
L
D
I
K
GRCDD
G
Y
H
E
L
A
M
I
M
V
S
ID-LND
Y
V
T
I
S
E
LKED
C
I
---
V
IDSDS-SKMP-LN-NDN
D
V
F
K
A
A
D
I
I
------
K
N
QYG------INK
G
V
H
I
R
L
EKSI
P
V
C
AGLGGGS
T
D
A
A
A
T
I
R
A
L
N
R
L
WNLQM
D
Y
D
E
M
V
A
I
G
F
KIG---------S---------DV---------
P
Y
CLGG
G
C
S
L
V
LGKG
E
-----
I
VKPL-PTLR
P
C
W
I
V
L
VKPDFGI
S
T
K
S
I
F
R
------DID--------C-KSI
S
-
R
-
V
------
D
I
D
L
L
K
-
S
A
I
LSS
D
Y
Q
L
M
V
K
S
MG--N--S-L
E
-
D
I
T
ITKN
P
---
V
I
S
T
I
K
E
R
M
LNSGA
D
--
V
A
L
M
TGSG
P
T
V
--
F
S
MCST
E
-
K
K
A
D
R
V
F
N
S
----
M
--
K
--
G
F
C
K
E
V
Y
K
V
RLLR--------------
3
PsiBlast_PDB
95.22
29%
-89
- C1 -
4EMD
2
?
A:
[21-299]
-----
R
A
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
L
R
D
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
A
D
D
V
T
V
R
D
A
D
V
L
S
I
D
--
V
V
G
Q
G
E
-
G
T
V
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
H
H
L
A
A
Q
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
Q
L
A
T
V
-
L
A
R
N
V
F
H
W
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
------
E
I
D
R
L
R
E
N
---
G
-
D
P
P
R
-
L
-
A
------
E
A
D
E
L
L
-
G
A
L
A
A
G
D
A
R
R
L
A
P
L
L
G
--
N
--
E
-
L
Q
-
A
A
A
V
S
L
N
P
---
E
L
R
R
T
L
R
A
G
E
S
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
D
D
A
V
Q
V
S
A
E
----
L
A
G
A
--
G
V
C
R
T
V
R
V
A
S
G
P
V
--------------
1
PsiBlast_PDB
92.63
29%
-87
- C1 -
4DXL
3
?
A:
[21-299]
-----
R
A
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
L
R
D
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
A
D
D
V
T
V
R
D
A
D
V
L
S
I
D
--
V
V
G
Q
G
E
-
G
T
V
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
H
H
L
A
A
Q
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
Q
L
A
T
V
-
L
A
R
N
V
F
H
W
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
------
E
I
D
R
L
R
E
N
---
G
-
D
P
P
R
-
L
-
A
------
E
A
D
E
L
L
-
G
A
L
A
A
G
D
A
R
R
L
A
P
L
L
G
--
N
--
E
-
L
Q
-
A
A
A
V
S
L
N
P
---
E
L
R
R
T
L
R
A
G
E
S
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
D
D
A
V
Q
V
S
A
E
----
L
A
G
A
--
G
V
C
R
T
V
R
V
A
S
G
P
V
--------------
2
PsiBlast_PDB
92.01
29%
-90
- C1 -
4ED4
1
?
A:
[21-299]
-----
R
A
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
L
----
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
A
D
D
V
T
V
R
D
A
D
V
L
S
I
D
--
V
V
G
Q
G
E
-
G
T
V
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
H
H
L
A
A
Q
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
Q
L
A
T
V
-
L
A
R
N
V
F
H
W
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
------
E
I
D
R
L
R
E
N
---
G
-
D
P
P
R
-
L
-
A
------
E
A
D
E
L
L
-
G
A
L
A
A
G
D
A
R
R
L
A
P
L
L
G
--
N
--
E
-
L
Q
-
A
A
A
V
S
L
N
P
---
E
L
R
R
T
L
R
A
G
E
S
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
D
D
A
V
Q
V
S
A
E
----
L
A
G
A
--
G
V
C
R
T
V
R
V
A
S
G
P
V
--------------
7
PsiBlast_PDB
90.29
28%
-92
- C1 -
3PYG
1
ISPE_MYCTU
A:
[9-287]
-----
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
V
D
E
V
T
V
R
--
N
A
D
V
L
S
L
E
L
V
G
E
G
A
-
D
Q
L
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
E
L
A
T
V
-
L
S
R
N
T
F
H
W
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
------
E
L
D
R
L
R
E
----
V
-
G
D
P
P
-
R
-
L
G
-----
E
P
G
P
V
L
-
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
--
N
--
E
-
M
Q
-
A
A
A
V
S
L
D
P
---
A
L
A
R
A
L
R
A
G
V
E
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
S
S
A
I
D
V
G
A
Q
----
L
--
S
G
A
G
V
C
R
T
V
R
V
A
T
G
P
V
--------------
4
PsiBlast_PDB
90.27
28%
-95
- C1 -
3PYD
1
ISPE_MYCTU
A:
[9-287]
-----
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
V
D
E
V
T
V
R
--
N
A
D
V
L
S
L
E
L
V
G
E
G
A
-
D
Q
L
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
E
L
A
T
V
-
L
S
R
N
T
F
H
W
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
------
E
L
D
R
L
R
E
----
V
-
G
D
P
P
-
R
-
L
G
-----
E
P
G
P
V
L
-
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
--
N
--
E
-
M
Q
-
A
A
A
V
S
L
D
P
---
A
L
A
R
A
L
R
A
G
V
E
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
S
S
A
I
D
V
G
A
Q
----
L
--
S
G
A
G
V
C
R
T
V
R
V
A
T
G
P
V
--------------
5
PsiBlast_PDB
89.19
28%
-92
- C1 -
3PYE
1
ISPE_MYCTU
A:
[9-287]
-----
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
V
D
E
V
T
V
R
--
N
A
D
V
L
S
L
E
L
V
G
E
G
A
-
D
Q
L
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
E
L
A
T
V
-
L
S
R
N
T
F
H
W
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
------
E
L
D
R
L
R
E
----
V
-
G
D
P
P
-
R
-
L
G
-----
E
P
G
P
V
L
-
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
--
N
--
E
-
M
Q
-
A
A
A
V
S
L
D
P
---
A
L
A
R
A
L
R
A
G
V
E
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
S
S
A
I
D
V
G
A
Q
----
L
--
S
G
A
G
V
C
R
T
V
R
V
A
T
G
P
V
--------------
6
PsiBlast_PDB
88.40
28%
-92
- C1 -
3PYF
1
ISPE_MYCTU
A:
[9-287]
-----
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
V
D
E
V
T
V
R
--
N
A
D
V
L
S
L
E
L
V
G
E
G
A
-
D
Q
L
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
E
L
A
T
V
-
L
S
R
N
T
F
H
W
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
------
E
L
D
R
L
R
E
----
V
-
G
D
P
P
-
R
-
L
G
-----
E
P
G
P
V
L
-
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
--
N
--
E
-
M
Q
-
A
A
A
V
S
L
D
P
---
A
L
A
R
A
L
R
A
G
V
E
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
S
S
A
I
D
V
G
A
Q
----
L
--
S
G
A
G
V
C
R
T
V
R
V
A
T
G
P
V
--------------
44
Fugue
87.10
31%
-89
- C1 -
1UEK
-
ISPE_THET8
A:
[1-268]
--
M
E
R
L
A
P
---
A
K
V
-
N
L
G
L
S
V
R
F
R
R
E
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
-
L
A
D
R
L
V
V
E
P
V
S
S
G
L
H
---
F
Q
G
-------
P
-
Y
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
E
V
D
---
L
F
A
L
A
R
T
L
G
---------
A
---------
D
V
---------
P
F
F
L
L
G
R
G
A
E
A
R
G
V
G
E
-----
R
L
K
P
L
-
A
-
L
P
P
V
P
A
V
V
F
F
P
G
L
R
V
P
T
P
L
V
Y
R
------
A
V
R
--------
P
-
E
D
F
G
-
P
----------
D
L
P
V
-
E
A
I
L
E
A
L
A
R
G
E
E
P
P
Y
W
--
N
--
S
-
L
E
-
G
P
A
F
R
L
F
P
---
E
L
K
E
V
R
G
R
M
R
A
L
G
L
R
--
G
V
L
M
S
G
S
G
S
A
F
--
F
G
L
A
E
G
P
-
D
H
A
R
R
A
A
E
A
----
L
--
R
--
A
W
G
R
A
W
A
G
T
L
G
G
G
--------------
22
HHSearch
84.36
29%
-92
- C1 -
1UEK
-
ISPE_THET8
A:
[1-264]
--
M
E
R
L
A
P
---
A
K
V
-
N
L
G
L
S
V
R
F
R
R
E
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
-
L
A
D
R
L
V
V
E
P
V
S
S
G
-
L
---
H
F
------
Q
G
P
-
Y
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
---
E
V
D
L
F
A
L
A
R
T
L
G
---------
A
---------
D
V
---------
P
F
F
L
L
G
R
G
A
E
A
R
G
V
G
E
-----
R
L
K
P
L
-
A
L
-
P
P
V
P
A
V
V
F
F
P
G
L
R
V
P
T
P
L
V
Y
R
------
A
V
R
--------
P
-
E
D
F
G
P
D
-
L
------
P
V
E
A
I
L
-
E
A
L
A
R
G
E
E
P
P
Y
W
N
S
L
E
--
G
--------
P
A
F
R
L
F
P
---
E
L
K
E
V
R
G
R
M
R
A
L
G
L
R
--
G
V
L
M
S
G
S
G
S
A
F
--
F
G
L
A
E
G
P
-
D
H
A
R
R
A
A
E
A
----
L
--
R
--
A
W
--
G
R
A
W
A
G
T
L
G
--------------
21
HHSearch
82.14
27%
-82
- C1 -
3PYF
1
ISPE_MYCTU
A:
[5-287]
-
S
V
T
V
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
-
L
V
D
E
V
T
V
R
N
A
D
V
L
S
L
---
E
L
V
G
E
G
A
D
Q
L
P
-
T
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
R
M
L
A
A
R
L
G
---------
S
---------
D
V
---------
P
F
A
L
H
G
G
T
A
L
G
T
G
R
G
E
-----
E
L
A
T
V
-
L
S
R
N
T
F
H
W
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
------
E
L
D
--------
R
-
L
R
E
V
-
G
-
D
P
P
R
L
G
-
E
P
G
P
V
L
-
A
A
L
A
A
G
D
P
D
Q
L
A
P
L
L
G
--
N
--
E
-
M
Q
A
A
A
V
S
-
L
D
P
---
A
L
A
R
A
L
R
A
G
V
E
A
G
A
L
--
A
G
I
V
S
G
S
G
P
T
C
--
A
F
L
C
T
S
A
-
S
S
A
I
D
V
G
A
Q
----
L
--
S
--
G
A
G
V
C
R
T
V
R
V
A
T
G
--------------
24
HHSearch
80.98
30%
-83
- C1 -
2WW4
2
ISPE_ECOLI
A:
[1-265]
M
R
T
Q
W
P
S
P
---
A
K
L
-
N
L
F
L
Y
I
T
G
Q
R
A
D
G
Y
H
T
L
Q
T
L
F
Q
F
L
D
-
Y
G
D
T
I
S
I
E
L
R
D
D
G
D
I
---
R
L
L
T
P
V
-
E
G
-
V
-
E
H
-
E
D
N
L
I
V
R
A
A
R
L
L
------
M
K
T
A
A
D
S
GRLP
T
G
S
G
A
N
I
S
I
D
K
R
L
P
M
G
G
G
L
G
G
G
S
S
N
A
A
T
V
L
V
A
L
N
H
L
W
Q
C
G
L
S
M
D
E
L
A
E
M
G
L
T
L
G
---------
A
---------
D
V
---------
P
V
F
V
R
G
H
A
A
F
A
E
G
V
G
E
-----
I
L
T
P
V
-
D
P
-
P
E
K
W
Y
L
V
A
H
P
G
V
S
I
P
T
P
V
I
F
K
------
D
P
E
--------
L
-
P
R
N
T
-
P
K
R
------
S
I
E
T
L
L
-
K
C
E
F
S
N
D
----------------
C
E
-
V
I
A
R
K
R
F
R
---
E
V
D
A
V
L
S
W
L
L
E
-
Y
-
A
--
P
S
R
L
T
G
T
G
A
C
V
--
F
A
E
F
D
T
E
-
S
E
A
R
Q
V
L
E
Q
----
A
--
P
--
E
W
L
N
G
F
V
A
K
G
V
N
L
--------------
9
PsiBlast_PDB
80.05
28%
-89
- C1 -
2WW4
2
ISPE_ECOLI
A:
[1-268]
M
R
T
Q
W
P
S
P
---
A
K
L
-
N
L
F
L
Y
I
T
G
Q
R
A
D
G
Y
H
T
L
Q
T
L
F
Q
F
L
D
-
Y
G
D
T
I
S
I
-
E
L
R
D
D
G
D
---
I
R
L
L
T
P
-
V
E
G
V
-
E
H
-
E
D
N
L
I
V
R
A
A
R
L
L
M
K
T
A
A
D
S
G
R
L
P
------
T
G
S
G
A
N
I
S
I
D
K
R
L
P
M
G
G
G
L
G
G
G
S
S
N
A
A
T
V
L
V
A
L
N
H
L
W
Q
C
G
L
S
M
D
E
L
A
E
M
G
L
T
L
G
---------
A
---------
D
V
---------
P
V
F
V
R
G
H
A
A
F
A
E
G
V
G
E
-----
I
L
T
P
V
D
P
P
E
K
--
W
Y
L
V
A
H
P
G
V
S
I
P
T
P
V
I
F
K
------
D
P
E
--------
L
P
R
N
T
P
-
K
-
R
------
S
I
E
T
L
L
-
K
C
E
F
S
N
D
C
E
V
I
A
R
K
R
F
--
R
--
E
-
V
--------
D
A
---
V
L
S
W
L
L
E
Y
A
P
S
R
--------
L
T
G
T
G
A
C
V
--
F
A
E
F
D
T
E
-
S
E
A
R
Q
V
L
E
Q
APEW
L
--
N
--
G
F
V
A
K
G
V
N
L
S
P
L
H
--------------
10
PsiBlast_PDB
79.99
28%
-87
- C1 -
1OJ4
3
ISPE_ECOL6
A:
[2-268]
-
R
T
Q
W
P
S
P
---
A
K
L
-
N
L
F
L
Y
I
T
G
Q
R
A
D
G
Y
H
T
L
Q
T
L
F
Q
F
L
D
-
Y
G
D
T
I
S
I
-
E
L
R
D
D
G
D
---
I
R
L
L
T
P
-
V
E
G
V
-
E
H
-
E
D
N
L
I
V
R
A
A
R
L
L
M
K
T
A
A
D
S
G
R
L
P
------
T
G
S
G
A
N
I
S
I
D
K
R
L
P
M
G
G
G
L
G
G
G
S
S
N
A
A
T
V
L
V
A
L
N
H
L
W
Q
C
G
L
S
M
D
E
L
A
E
M
G
L
T
L
G
---------
A
---------
D
V
---------
P
V
F
V
R
G
H
A
A
F
A
E
G
V
G
E
-----
I
L
T
P
V
D
P
P
E
K
--
W
Y
L
V
A
H
P
G
V
S
I
P
T
P
V
I
F
K
------
D
P
E
--------
L
P
R
N
T
P
-
K
-
R
------
S
I
E
T
L
L
-
K
C
E
F
S
N
D
C
E
V
I
A
R
K
R
F
--
R
--
E
-
V
--------
D
A
---
V
L
S
W
L
L
E
Y
A
P
S
R
--------
L
T
G
T
G
A
C
V
--
F
A
E
F
D
T
E
-
S
E
A
R
Q
V
L
E
Q
APEW
L
--
N
--
G
F
V
A
K
G
V
N
L
S
P
L
H
--------------
8
PsiBlast_PDB
78.01
32%
-88
- C1 -
1UEK
-
ISPE_THET8
A:
[5-241]
------
A
P
---
A
K
V
-
N
L
G
L
S
V
R
F
R
R
E
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
-
L
A
D
R
L
V
V
E
P
V
S
S
G
L
---------
H
-
F
Q
G
P
-
Y
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
E
V
D
---
L
F
A
L
A
R
T
L
G
---------
A
---------
D
V
---------
P
F
F
L
L
G
R
G
A
E
A
R
G
V
G
E
-----
R
L
K
P
L
--
A
L
P
P
V
P
A
V
V
F
F
P
G
L
R
V
P
T
P
L
V
Y
R
------
A
V
R
--------
P
-
E
D
F
G
-----------
P
D
L
P
V
-
E
A
I
L
E
A
L
A
R
G
E
E
P
P
Y
W
--
N
--
S
-
L
E
-
G
P
A
F
R
L
F
P
---
E
L
K
E
V
R
G
R
M
R
A
L
G
L
R
--
G
V
L
M
S
G
S
G
S
A
F
--
F
G
L
A
E
G
P
-
D
H
A
R
R
A
A
E
A
----
L
--
R
--
A
W
G
R
A
W
A
G
T
L
G
G
G
--------------
28
HHSearch
76.01
22%
-92
- C1 -
1H72
3
KHSE_METJA
C:
[1-286]
M
K
V
R
V
K
A
P
---
C
T
S
-
A
N
L
----
G
V
G
F
D
------
V
F
G
L
C
L
K
E
P
Y
D
V
I
E
V
E
A
I
D
D
K
E
I
---
I
I
E
V
D
D
-
K
N
I
P
T
D
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
LASSGAKHA
D
---------
N
V
---------
A
P
A
I
F
G
G
F
T
M
V
T
N
Y
E
P
L----
E
V
L
H
I
-
P
I
D
F
K
L
D
I
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
------
I
L
P
--------
K
-
A
V
G
L
-
K
-
D
LVNNVG
K
A
C
G
M
V
-
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
--
S
DK
V
I
E
P
-
V
R
G
K
-
L
I
P
---
N
Y
F
K
I
K
E
E
V
K
D
-
K
V
Y
--
G
I
T
I
S
G
S
G
P
S
I
--
I
A
F
P
K
E
E
--
F
I
D
E
V
E
N
I
----
L
--
R
--
D
Y
Y
E
N
T
I
R
T
E
V
G
K
--------------
48
Fugue
75.79
22%
-97
- C1 -
1H74
2
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
---
C
T
S
A
N
L
G
V
--------
G
F
D
V
F
G
L
C
L
K
E
P
---
Y
D
V
I
E
V
E
A
I
D
D
K
E
I
---
I
I
E
V
D
D
-
K
N
I
P
-
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
---------
L
A
S
SGAKHA
D
N
V
---------
A
P
A
I
F
G
G
F
T
M
V
T
N
Y
E
P
L
----
E
V
L
H
I
-
P
I
D
F
K
L
D
I
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
ILPKAV
G
L
K
--------
D
-
L
V
N
N
-
V
-
G
------
K
A
C
G
M
V
-
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
--
S
DK
V
-
I
E
-
P
V
R
G
K
L
I
P
---
N
Y
F
K
I
K
E
E
V
K
D
K
-
V
Y
--
G
I
T
I
S
G
S
G
P
S
I
--
I
A
F
P
K
-
E
-
E
F
I
D
E
V
E
N
I
----
L
--
R
--
D
Y
Y
E
N
T
I
R
T
E
V
G
K
GVEVV---------
49
Fugue
75.76
22%
-102
* C1 *
1H72
3
KHSE_METJA
C:
[1-296]
M
K
V
R
V
K
A
P
---
C
T
S
A
N
L
G
V
G
F
D
-----------
V
F
G
L
C
L
K
E
P
Y
D
V
I
E
V
E
A
I
D
D
K
E
I
---
I
I
E
V
D
D
-
K
N
I
P
-
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
---------
L
---------
A
S
SGAKHADNV
A
P
A
I
F
G
G
F
T
M
V
T
N
Y
--EPLEV
L
H
I
P
I
---
D
F
K
L
D
I
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
------
I
--LPKAVGLK
D
-
L
V
N
N
-
V
-
G
------
K
A
C
G
M
V
-
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
SD
K
--
V
-
I
E
-
P
V
R
G
K
---LIP
N
Y
F
K
I
K
E
E
V
K
D
K
---VY
G
I
T
I
S
G
S
G
P
S
I
--
I
A
F
P
K
-
E
-
E
F
I
D
E
V
E
N
I
----
L
--
R
--
D
Y
Y
E
---------NTIRTEVGKGVEVV
47
Fugue
74.66
21%
-91
- C1 -
1H72
3
KHSE_METJA
C:
[1-296]
M
K
V
R
V
K
A
P
CTS
A
N
L
-
G
V
G
F
D
------------
V
F
G
L
C
L
K
E
-
P
Y
D
V
I
E
V
E
A
I
D
D
K
E
I
---
I
I
E
V
D
D
-
K
N
I
P
-
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
V
D
Y
A
S
Y
G
E
---------
L
---------
A
S
SGAKHADNV
A
P
A
I
F
G
G
F
T
M
V
T
N
Y
E
P
L----
E
V
L
H
I
-
P
I
D
F
K
L
D
I
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
ILPKAV
G
L
K
--------
D
-
L
V
N
N
-
V
-
G
------
K
A
C
G
M
V
-
Y
A
L
Y
N
K
D
K
S
L
F
G
R
Y
M
M
--
S
DK
V
-
I
E
-
P
V
R
G
K
L
I
P
---
N
Y
F
K
I
K
E
E
V
K
D
K
-
V
Y
--
G
I
T
I
S
G
S
G
P
S
I
--
I
A
F
P
K
-
E
-
E
F
I
D
E
V
E
N
I
----
L
--
R
--
D
Y
Y
E
N
T
I
R
T
E
V
G
K
GVEVV---------
14
PsiBlast_PDB
74.52
29%
-78
- C1 -
2V34
7
ISPE_AQUAE
A:
[9-264]
------
S
P
---
A
K
I
-
N
L
G
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
-
F
Y
D
E
I
Y
I
---
R
E
G
V
L
---
R
V
E
T
N
I
-
G
-
I
P
--
Q
-
E
E
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
R
E
L
V
G
S
I
S
---------
A
---------
D
A
---------
P
F
F
L
L
G
K
S
A
I
G
R
G
K
G
E
-----
V
L
E
P
V
-
E
T
E
I
S
G
K
I
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
------
S
L
R
--------
E
-
E
H
F
V
-
T
-
P
------
E
Y
A
E
E
K
I
Q
R
I
I
S
G
E
----
V
E
E
I
E
--
N
--
V
-
L
G
-
D
I
A
R
E
L
Y
P
---
E
I
N
E
V
Y
-
R
F
V
E
Y
L
G
F
--
K
P
F
V
S
G
S
G
S
T
V
Y
F
F
G
G
A
S
E
E
L
K
K
A
A
K
--------
M
--
R
--
G
W
K
V
V
E
L
E
L
------------------
16
PsiBlast_PDB
74.07
29%
-78
- C1 -
2VF3
6
ISPE_AQUAE
A:
[9-264]
------
S
P
---
A
K
I
-
N
L
G
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
-
F
Y
D
E
I
Y
I
---
R
E
G
V
L
---
R
V
E
T
N
I
-
G
-
I
P
--
Q
-
E
E
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
R
E
L
V
G
S
I
S
---------
A
---------
D
A
---------
P
F
F
L
L
G
K
S
A
I
G
R
G
K
G
E
-----
V
L
E
P
V
-
E
T
E
I
S
G
K
I
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
------
S
L
R
--------
E
-
E
H
F
V
-
T
-
P
------
E
Y
A
E
E
K
I
Q
R
I
I
S
G
E
----
V
E
E
I
E
--
N
--
V
-
L
G
-
D
I
A
R
E
L
Y
P
---
E
I
N
E
V
Y
-
R
F
V
E
Y
L
G
F
--
K
P
F
V
S
G
S
G
S
T
V
Y
F
F
G
G
A
S
E
E
L
K
K
A
A
K
--------
M
--
R
--
G
W
K
V
V
E
L
E
L
------------------