@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0804: (2015-12-03 )
MTSISDIAKKAGVAKSTVSRVINHHPHVSDETRQKVMALITELDYIPNQLARDLSRGKTQKIGVVIPHTRHPYFTQLINGLLDAAKTTDYQLVMMPSDYNQELELSYLKQLKMEAIDALIFTSRAISLDIIETYAKYGRIVVCEKLQEYNHLSSAYLDRYSSFLEAFSDMKLRGLEHLVLLFSRNNESSATYQSALLAYQEVYGQLSSPYMVVGNVHDFNDGLNLSYQLVKEVSIDGILATSDEVAAGLIKGYEESRKKCPYIIGQECLLVGQLLKLPTIDHKSYYLGKLAFKQALAEKISQEVLFSEFLSQDN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.......-----.--70.--.......80........90........100.......110.......120......----.130.-..--.-..-.----140......-.-150.......160.......170.......180.......190..-.....200...----....----210-.-.-...-.---...220...-.....230.-.......240.......250.......260--.---.......270..-------.--.--...280.......290.......300----.-----........310..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
I
S
D
I
A
K
KAGV
A
K
S
T
V
S
R
V
I
NHHPHV
S
D
E
T
R
Q
K
V
M
A
L
I
T
E
L
D
Y
I
P
N
Q
L
A
R
D
L
SRGK
T
Q
K
I
G
V
V
IPH-----T--R
H
P
--
Y
F
T
Q
L
I
N
G
L
L
DAAKTT
D
Y
Q
L
V
MMPSDYN
Q
E
L
E
L
S
Y
L
K
Q
L
K
M
E
A
I
D
A
L
I
FTSRAI
S
L
----
D
I
I
E
T
-
Y
A
--K-YG-R----
I
V
V
C
E
K
L
Q
E
-Y-N
H
L
S
S
A
Y
L
D
R
Y
S
S
F
L
E
A
F
S
D
M
K
L
R
G
L
E
H
L
V
L
L
F
SRNNES
S
A
T
Y
Q
S
-
A
L
L
A
Y
Q
E
V
Y
G
Q----LSS
P
----
Y
---
M
-
V
-
V
G
N
-V---HDFN-DGL
N
-
L
S
Y
Q
L
V
-
K
E
-VSID
G
I
LA
T
S
D
E
V
A
A
G
L
I
K
G
Y
E
E
S
RKKC
P
---
Y
---
I
I
G
Q
E
C
L
L
V
G
Q
L
-------
L
--K--LPTIDHK
S
Y
Y
L
G
K
L
A
F
K
Q
A
L
A
E
K
I
------
S
-----
Q
E
V
L
F
S
E
F
LSQDN
2
PsiBlast_PDB
91.38
26%
-103
- C3 -
1ZVV
4
CCPA_BACSU
A:
[4-303]
--
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
N
I
--
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
----
E
H
V
E
E
-
L
K
--
K
-
S
P
V
P
----
V
V
L
A
A
S
I
E
S
-
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
-
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
----
S
G
L
P
V
R
DS
Y
---
I
-
V
-
E
G
D
-----
Y
T
Y
D
-
S
G
I
E
-
A
V
E
K
L
L
-
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
---
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
-------
V
--
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
------
K
-----
E
T
V
D
S
S
I
V
E
L
P
H
R
3
PsiBlast_PDB
91.06
26%
-101
- C3 -
1RZR
5
CCPA_BACME
D:
[4-303]
--
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
N
I
--
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
----
E
H
V
E
E
-
L
K
--
K
-
S
P
V
P
----
V
V
L
A
A
S
I
E
S
-
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
-
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
----
S
G
L
P
VRDS
Y
---
I
-
V
-
E
G
D
-----
Y
T
Y
D
-
S
G
I
E
-
A
V
E
K
L
L
-
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
---
N
DLE
I
I
G
F
D
N
T
R
L
S
T
M
-------
V
--
R
PQ
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
------
K
-----
E
T
V
D
S
S
I
V
Q
L
P
H
R
1
PsiBlast_PDB
88.89
26%
-106
- C3 -
2HSG
-
CCPA_BACME
A:
[4-303]
--
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
---------
S
N
I
--
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
----
E
H
V
E
E
-
L
K
--
K
-
S
P
V
P
----
V
V
L
A
A
S
I
E
S
-
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
-
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
----
S
G
L
P
VRDS
Y
---
I
-
V
-
E
G
D
-----
Y
T
Y
D
-
S
G
I
E
-
A
V
E
K
L
L
-
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
---
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
-------
V
--
R
PQ
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
------
K
-----
E
T
V
D
S
S
I
V
Q
L
P
H
R
48
HHSearch
88.14
25%
-97
- C3 -
2HSG
-
CCPA_BACME
A:
[2-330]
N
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
---------
S
N
I
--
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
----
E
H
V
E
E
-
L
K
--
K
S
P
V
-
P
----
V
V
L
A
A
S
I
E
S
-
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
-
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
----
S
G
L
P
----
V
RDS
Y
-
I
-
V
E
G
-
D
---
Y
T
Y
D
-
S
G
I
E
-
A
V
E
K
L
L
E
E
D
-
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
ND
L
E
---
I
I
G
F
D
N
T
R
L
S
T
M
-------
V
RP
Q
--
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
-----
I
V
Q
L
P
H
R
I
E
F
R
Q
S
53
HHSearch
83.94
21%
-91
- C3 -
1QPZ
2
PURR_ECOLI
A:
[1-329]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
-----
S
--
E
A
A
--
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
----
P
L
L
A
M
-
L
E
E
Y
R
-
H
I
-
P
----
M
V
V
M
D
W
G
E
A
-
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
--
R
N
T
G
A
G
-
R
L
A
G
F
M
K
A
M
E
E
----
A
M
I
K
V
P
E-
S
---
W
-
I
-
V
Q
G
-
D
---
F
E
P
E
-
S
G
Y
R
-
A
M
Q
Q
I
L
S
Q
P
-
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
QD
V
S
---
L
I
G
Y
D
N
V
R
N
A
R
Y
FT-----
P
--
A
--
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
NKRE
E
P
Q
-----
S
I
E
V
H
P
R
L
I
E
R
R
S
5
PsiBlast_PDB
83.65
26%
-96
- C3 -
3OQN
2
CCPA_BACSU
A:
[4-303]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
S
I
--
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
-------
D
E
H
-
V
A
--
E
-
F
K
-
R
SP
V
P
I
V
L
A
A
S
V
E
E
-
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
--
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
----
A
N
L
P
----
F
N
EQ
F
-
V
-
A
E
G
-
D
---
Y
T
Y
D
-
S
G
L
E
A
L
Q
H
L
M
S
-
L
D
-
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
---
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
-------
V
--
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
------
K
-----
E
P
V
E
E
H
I
V
E
L
P
H
R
6
PsiBlast_PDB
83.12
26%
-93
- C3 -
3OQO
4
CCPA_BACSU
A:
[4-303]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
S
I
--
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
-------
D
E
H
-
V
A
--
E
-
F
K
-
R
SP
V
P
I
V
L
A
A
S
V
E
E
-
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
--
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
----
A
N
L
P
----
F
N
EQ
F
-
V
-
A
E
G
-
D
---
Y
T
Y
D
-
S
G
L
E
A
L
Q
H
L
M
S
-
L
D
-
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
---
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
-------
V
--
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
------
K
-----
E
P
V
E
E
H
I
V
E
L
P
H
R
4
PsiBlast_PDB
82.87
26%
-95
- C3 -
3OQM
4
CCPA_BACSU
A:
[4-303]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
S
I
--
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
-------
D
E
H
-
V
A
--
E
-
F
K
-
R
SP
V
P
I
V
L
A
A
S
V
E
E
-
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
--
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
----
A
N
L
P
----
F
N
EQ
F
-
V
-
A
E
G
-
D
---
Y
T
Y
D
-
S
G
L
E
A
L
Q
H
L
M
S
-
L
D
-
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
---
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
-------
V
--
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
------
K
-----
E
P
V
E
E
H
I
V
E
L
P
H
R
50
HHSearch
75.89
25%
-98
* C3 *
2O20
3
?
A:
[62-330]
---------------------------------------------------------
R
T
T
T
V
G
V
I
L
P
T
-----
I
--
T
S
T
--
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
K
Y
N
M
I
L
A
N
S
D
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
K
Q
V
D
G
I
V
Y
M
G
S
S
L
D
E
----
K
I
R
T
S
-
L
K
--
N
S
R
T
-
P
----
V
V
L
V
G
T
I
D
G
-
D
-
K
E
I
P
S
V
N
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
G
N
K
K
I
A
Y
I
M
G
S
L
K
--
D
V
E
N
T
E
-
R
M
V
G
Y
Q
E
A
L
L
E
----
A
N
I
E
F
D
E-
N
---
L
-
V
-
F
E
G
-
N
---
Y
S
Y
E
-
Q
G
K
A
-
L
A
E
R
L
L
--
E
-
R
G
A
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
A
M
M
D
K
G
V
K
V
P
ED
F
E
---
I
I
S
G
A
N
S
P
I
T
Q
Y
TY-----
P
--
T
--
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
KEDVEQ
N
-----
Q
L
V
L
D
H
E
I
F
S
R
R
S
49
HHSearch
72.19
23%
-92
- C3 -
3DBI
2
ASCG_ECOLI
A:
[60-332]
---------------------------------------------------------
S
T
Q
T
L
G
L
V
V
T
N
-----
T
LY
H
G
I
--
Y
F
S
E
L
L
F
H
A
A
R
M
A
E
E
K
G
R
Q
L
L
L
A
D
G
K
H
S
A
E
E
E
R
Q
A
I
Q
Y
L
L
D
L
R
C
D
A
I
M
I
Y
P
R
F
L
S
V
----
D
E
I
D
D
I
I
D
--
A
H
S
Q
-
P
----
I
M
V
L
N
R
R
L
R
-
K
-
N
S
S
H
S
V
W
C
D
H
K
Q
T
S
F
N
A
V
A
E
L
I
N
A
G
H
Q
E
I
A
F
L
T
G
S
M
D
--
S
P
T
S
I
E
-
R
L
A
G
Y
K
D
A
L
A
Q
----
H
G
I
A
----
L
NEK
L
-
I
-
A
N
G
-
K
---
W
T
P
A
-
S
G
A
E
-
G
V
E
M
L
L
E
R
G
-
A
K
F
S
A
L
V
A
S
N
D
D
M
A
I
G
A
M
K
A
L
H
E
R
G
V
A
V
P
EQ
V
S
---
V
I
G
F
D
D
I
A
I
A
P
Y
TV-----
P
--
A
--
L
S
S
V
K
I
P
V
T
E
M
I
Q
E
I
I
G
R
L
I
F
M
L
D
------
G
GDFSP
P
K
T
F
S
G
K
L
I
R
R
D
S
65
HHSearch
71.57
21%
-90
- C3 -
2FEP
2
CCPA_BACSU
A:
[16-286]
----------------------------------------------------------
T
T
T
V
G
V
I
I
P
D
-----
I
--
S
S
I
--
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
D
----
E
H
V
A
E
-
F
K
R
-
S
-
P
V
-
P
----
I
V
L
A
A
S
V
E
E
-
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
-
P
I
N
R
S
K
-
K
L
Q
G
Y
K
R
A
L
E
E
----
A
N
L
P
----
F
N
EQ
F
-
V
-
A
E
G
-
D
---
Y
T
Y
D
-
S
G
L
E
-
A
L
Q
H
L
M
S
L
D
-
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
ED
L
D
---
I
I
G
F
D
N
T
R
L
S
L
M
-------
V
RP
Q
--
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
KEPVEE
H
-----
I
V
E
L
P
H
R
I
E
L
R
K
S
66
HHSearch
69.75
19%
-89
- C3 -
3C3K
1
?
A:
[7-276]
---------------------------------------------------------
K
T
G
M
L
L
V
M
V
S
N
-----
I
--
A
N
P
--
F
C
A
A
V
V
K
G
I
E
K
T
A
E
K
N
G
Y
R
I
L
L
C
N
T
E
S
D
L
A
R
S
R
S
C
L
T
L
L
S
G
K
M
V
D
G
V
I
T
M
D
A
L
S
E
L
----
P
E
L
Q
N
-
I
I
--
G
-
A
F
-
P
----
W
V
Q
C
A
E
Y
D
P
-
L
-
S
T
V
S
S
V
S
I
D
D
V
A
A
S
E
Y
V
V
D
Q
L
V
K
S
G
K
K
R
I
A
L
I
N
H
D
L
A
--
Y
Q
Y
A
Q
H
-
R
E
S
G
Y
L
N
R
L
K
F
----
H
G
L
D
----
Y
---
S
R
I
S
Y
A
E
-
N
---
L
D
Y
M
-
A
G
K
L
-
A
T
F
S
L
L
K
S
A
-
V
K
P
D
A
I
F
A
I
S
D
V
L
A
A
G
A
I
Q
A
L
T
E
S
G
L
S
I
P
QD
V
A
---
V
V
G
F
D
G
V
D
I
S
Q
I
TV-----
P
--
A
--
L
T
T
V
Q
Q
P
S
E
Q
I
G
M
K
A
V
S
L
L
L
E
Q
I
H
SD----
V
-----
H
H
L
L
P
W
K
F
V
R
R
Q
S
67
HHSearch
69.17
17%
-98
- C3 -
3K4H
1
?
A:
[7-283]
---------------------------------------------------------
T
T
K
T
L
G
L
V
M
P
S
S
A
S
K
A
F
--
Q
N
P
--
F
F
P
E
V
I
R
G
I
S
S
F
A
H
V
E
G
Y
A
L
Y
M
S
T
G
E
T
E
E
E
I
F
N
G
V
V
K
M
V
Q
G
R
Q
I
G
G
I
I
L
L
Y
S
R
E
N
D
----
R
I
I
Q
Y
-
L
H
--
E
Q
N
F
-
P
----
F
V
L
I
G
K
P
Y
D
R
K
-
D
E
I
T
Y
V
D
N
D
N
Y
T
A
A
R
E
V
A
E
Y
L
I
S
L
G
H
K
Q
I
A
F
I
G
G
G
S
D
--
L
L
V
T
R
D
-
R
L
A
G
M
S
D
A
L
K
L
----
A
D
I
V
L
P
K-
E
---
Y
-
I
-
L
H
F
-
D
---
F
S
R
E
-
S
G
Q
Q
-
A
V
E
E
L
M
G
L
Q
-
Q
P
P
T
A
I
M
A
T
D
D
L
I
G
L
G
V
L
S
A
L
S
K
K
G
F
V
V
P
KD
V
S
---
I
V
S
F
N
N
A
L
L
S
E
I
AS-----
P
--
P
--
L
S
T
V
D
V
N
I
Y
Q
L
G
Y
E
A
A
K
A
L
V
D
K
V
E
N
AE
S
T
A
K
-----
C
I
I
I
P
H
K
L
L
K
R
Q
T
58
HHSearch
67.48
20%
-91
- C3 -
3BRQ
2
ASCG_ECOLI
A:
[19-290]
----------------------------------------------------------
T
Q
T
L
G
L
V
V
T
N
-----
T
LY
H
----
Y
F
S
E
L
L
F
H
A
A
R
M
A
E
E
K
G
R
Q
L
L
L
A
D
G
K
H
S
A
E
E
E
R
Q
A
I
Q
Y
L
L
D
L
R
C
D
A
I
M
I
Y
P
R
F
L
S
V
----
D
E
I
D
D
I
I
D
--
A
H
S
Q
-
P
----
I
M
V
L
N
R
R
L
R
-
K
-
N
S
S
H
S
V
W
C
D
H
K
Q
T
S
F
N
A
V
A
E
L
I
N
A
G
H
Q
E
I
A
F
L
T
G
S
M
D
--
S
P
T
S
I
E
-
R
L
A
G
Y
K
D
A
L
A
Q
----
H
G
I
A
----
L
N
EK
L
-
I
-
A
N
G
-
K
---
W
T
P
A
-
S
G
A
E
-
G
V
E
M
L
L
E
R
---
K
F
S
A
L
V
A
S
N
D
D
M
A
I
G
A
M
K
A
L
H
E
R
G
V
A
V
P
EQ
V
S
---
V
I
G
F
D
D
I
A
I
A
P
Y
TV-----
P
--
A
--
L
S
S
V
K
I
P
V
T
E
M
I
Q
E
I
I
G
R
L
I
F
M
L
D
------
G
G
D
F
S
P
P
K
T
F
S
G
K
L
I
R
R
D
S
9
PsiBlast_PDB
67.03
25%
-84
- C3 -
3DBI
2
ASCG_ECOLI
A:
[60-310]
---------------------------------------------------------
S
T
Q
T
L
G
L
V
V
T
N
-----
T
--
L
Y
H
GI
Y
F
S
E
L
L
F
H
A
A
R
M
A
E
E
K
G
R
Q
L
L
L
A
D
G
K
H
S
A
E
E
E
R
Q
A
I
Q
Y
L
L
D
L
R
C
D
A
I
M
I
Y
P
R
F
L
S
V
D
E
I
D
D
I
I
D
A
-
H
S
--
Q
----
P
----
I
M
V
L
N
R
R
L
R
-
K
-
N
S
S
H
S
V
W
C
D
H
K
Q
T
S
F
N
A
V
A
E
L
I
N
A
G
--
H
Q
E
I
A
F
L
T
G
S
M
D
S
P
T
S
I
E
-
R
L
A
G
Y
K
D
A
L
A
Q
H
GIA
L
N
E
K
----
L
---
I
-
A
-
N
G
K
-
W
---
T
P
A
S
-
G
A
E
G
-
V
E
M
L
L
E
-
R
G
-
A
K
F
S
A
L
V
A
S
N
D
D
M
A
I
G
A
M
K
A
L
H
E
R
G
V
A
V
P
EQ
V
S
---
V
I
G
F
D
D
I
A
I
A
P
Y
TVPA
L
S
S
V
--
K
--
I
P
V
T
E
M
I
Q
E
I
I
G
R
L
I
F
M
L
D
G
G
D
F
S
------
P
-----
P
K
T
F
S
G
K
L
I
R
R
D
S
8
PsiBlast_PDB
65.81
26%
-99
- C3 -
3CTP
2
?
A:
[60-284]
----------------------------------------------------------
S
K
T
I
G
L
M
V
P
N
-----
I
--
S
N
P
--
F
F
N
Q
M
A
S
V
I
E
E
Y
A
K
N
K
G
Y
T
L
F
L
C
N
T
D
D
D
K
E
K
E
K
T
Y
L
E
V
L
Q
S
H
R
V
-
A
G
I
I
A
S
R
S
Q
C
E
----
D
---
E
-
Y
A
--
N
-
I
D
-
I
----
P
V
V
A
F
E
N
H
I
-
L
-
D
N
I
I
T
I
S
S
D
N
Y
N
G
G
R
M
A
F
D
H
L
Y
E
K
G
C
R
K
I
L
H
I
-----
K
G
P
E
V
F
E
A
-
T
E
L
R
Y
K
G
F
L
D
G
----
A
R
A
K
----
D
---
L
-
E
-
I
D
F
-
I
E
F
Q
H
D
F
Q
V
K
M
L
E
-
E
D
I
N
S
M
-
K
D
I
V
N
Y
D
G
I
F
V
F
N
D
I
A
A
A
T
V
M
R
A
L
K
K
R
G
V
S
I
P
QE
V
Q
---
I
I
G
F
D
N
S
F
I
G
E
L
-------
L
YP
S
--
L
T
T
I
N
Q
P
I
E
A
L
A
Y
T
I
I
E
L
L
I
K
I
I
N
------
G
-----
E
G
V
L
I
E
D
Y
I
M
E
V
K
52
HHSearch
64.08
17%
-101
- C3 -
3BIL
-
?
A:
[67-331]
------------------------------------------------------------
T
I
G
V
I
V
P
S
-----
L
--
I
N
H
--
Y
F
A
A
M
V
T
E
I
Q
S
T
A
S
K
A
G
L
A
T
I
I
T
N
S
N
E
D
A
T
T
M
S
G
S
L
E
F
L
T
S
H
G
V
D
G
I
I
C
V
P
N
E
E
C
A
----
N
Q
L
E
D
-
L
Q
--
K
Q-
M
-
P
----
V
V
L
V
D
R
E
L
P
-
G
D-
T
I
P
T
A
T
S
N
P
Q
P
G
I
A
A
A
V
E
L
L
A
H
N
N
A
L
P
I
G
Y
L
S
G
P
M
D
--
T
S
T
G
R
E
-
R
L
E
D
F
K
A
A
C
A
N
----
S
K
I
G
E
---
Q
---
L
-
V
-
F
L
G
-
G
---
Y
E
Q
S
-
V
G
F
E
-
G
A
T
K
L
L
--
D
-
Q
G
A
K
T
L
F
A
G
D
S
M
M
T
I
G
V
I
E
A
C
H
K
A
G
L
V
I
G
KD
V
S
---
V
I
G
F
D
T
H
P
L
F
A
L
QP-----
H
--
P
--
L
T
V
I
D
Q
N
V
E
Q
L
A
Q
R
A
V
S
I
L
T
E
L
---------------
T
T
I
P
T
A
L
I
H
R
E
S
61
HHSearch
63.66
16%
-99
- C3 -
3K9C
1
?
A:
[13-274]
-----------------------------------------------------------
R
L
L
G
V
V
F
E
------
L
--
Q
Q
P
--
F
H
G
D
L
V
E
Q
I
Y
A
A
A
T
R
R
G
Y
D
V
M
L
S
A
V
A
P
S
R
-
A
E
K
V
A
V
Q
A
L
M
R
E
R
C
E
A
A
I
L
L
G
T
R
F
D
T
----
D
E
L
G
A
-
L
A
--
D
-
R
V
-
P
----
A
L
V
V
A
R
A
S
G
-
L
-
P
G
V
G
A
V
R
G
D
D
V
A
G
I
T
L
A
V
D
H
L
T
E
L
G
H
R
N
I
A
H
I
D
G
A
D
---
A
P
G
G
A
D
-
R
R
A
G
F
L
A
A
M
D
R
----
H
G
L
S
----
A
S
A
-
T
-
V
-
V
T
G
-
G
---
T
T
E
T
-
E
G
A
E
-
G
M
H
T
L
L
E
M
P
-
T
P
P
T
A
V
V
A
F
N
D
R
C
A
T
G
V
L
D
L
L
V
R
S
G
R
D
V
P
AD
I
S
---
V
V
G
Y
D
D
S
R
L
A
R
I
PH-----
V
--
Q
--
M
T
T
I
S
Q
D
A
T
H
M
A
E
A
A
V
D
G
A
L
A
Q
I
S
GDKA--
V
-----
D
L
V
L
A
P
H
L
V
R
R
A
T
51
HHSearch
62.66
20%
-91
- C3 -
3H5O
2
?
A:
[63-330]
-----------------------------------------------------------
R
T
V
L
V
L
I
P
S
-----
L
--
A
N
T
--
V
F
L
E
T
L
T
G
I
E
T
V
L
D
A
A
G
Y
Q
M
L
I
G
N
S
H
Y
D
A
G
Q
E
L
Q
L
L
R
A
Y
L
Q
H
R
P
D
G
V
L
I
T
G
L
S
H
A
E
----
P
F
E
R
I
-
L
S
--
Q
H
A
L
-
P
----
V
V
Y
M
M
D
L
A
D
-
D
--
G
R
C
C
V
G
F
S
Q
E
D
A
G
A
A
I
T
R
H
L
L
S
R
G
K
R
R
I
G
F
L
G
A
Q
L
D
---
E
R
V
M
K
-
R
L
D
G
Y
R
A
A
L
D
A
----
A
D
C
R
DAG-
L
---
E
-
W
-
L
D
P
Q
P
---
S
S
M
Q
-
M
G
A
D
-
M
L
D
R
A
L
A
E
R
-
P
D
C
D
A
L
F
C
C
N
D
D
L
A
I
G
A
L
A
R
S
Q
Q
L
G
I
A
V
P
ER
L
A
---
I
A
G
F
N
D
L
Q
P
A
A
W
CT-----
P
--
P
--
L
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
GEEPAS
R
-----
R
A
D
L
G
F
R
L
M
L
R
R
S
46
HHSearch
61.23
18%
-90
- C3 -
3JVD
3
?
A:
[64-322]
----------------------------------------------------------
S
A
L
V
G
V
I
V
P
D
-----
L
--
S
N
E
--
Y
Y
S
E
S
L
Q
T
I
Q
Q
D
L
K
A
A
G
Y
Q
M
L
V
A
E
A
N
S
V
Q
-
A
Q
D
V
V
M
E
S
L
I
S
I
Q
A
A
G
I
I
H
V
P
V
V
G
S
---------
I
-
A
---
E
-
G
I
-
P
----
M
V
Q
L
T
R
------
P
G
F
P
R
V
L
C
D
D
E
A
G
F
F
Q
L
T
E
S
V
L
G
G
S
G
M
N
I
A
A
L
V
G
E
E
S
--
L
S
T
T
Q
E
-
R
M
R
G
I
S
H
A
A
S
I
----
Y
G
A
E
----
V
---
T
-
F
-
H
F
G
-
H
---
Y
S
V
E
-
S
G
E
E
-
M
A
Q
V
V
F
-
N
N
-
G
L
P
D
A
L
I
V
A
S
P
R
L
M
A
G
V
M
R
A
F
T
R
L
N
V
R
V
P
HD
V
V
---
I
G
G
Y
D
D
P
E
W
Y
S
F
VG-----
A
--
G
--
I
T
T
F
V
P
P
H
E
E
M
G
K
E
A
V
R
L
L
V
D
L
I
E
N
PET--
G
-----
D
V
V
L
Q
G
Q
V
I
L
R
G
S