@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0819: (2015-12-03 )
MRVITVKNDIEGGKIAFTLLEEKMKAGAQTLGLATGSSPITFYEEIVKSNLDFSNMVSINLDEYVGIAASNDQSYSYFMHKHLFDAKPFKENNLPNGLAKDLKEEIKRYDAVINANPIDFQILGIGRNGHIGFNEPGTPFDITTHVVDLAPSTIEANSRFFNSIDDVPKQALSMGIGSIMKSKTIVLVAYGIEKAEAIASMIKGPITEDMPASILQKHDDVVIIVDEAAASKL
Atome Classification :
(26 SA)
.........10........20...-----.-----..-..30-----.........40.......----.----50........60........70........80...---...--..90..--......100.......-110.-..-....120.......130.......140.......150..-.....160..-.-.....170.......180.......190.......200.......210.......220.......230.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
V
I
T
VKNDIEGG
K
I
A
F
T
L
L
E
E
K
M
-----
K
-----AG-A
Q
T
------
L
GLATGS
S
P
I
T
F
Y
E
E
I
V
K
----S----NLDFS
N
M
V
S
I
N
L
D
E
Y
V
G
I
AASNDQ
S
Y
S
Y
F
M
H
K
H
LF---DAK--PFKENN--LP
N
G
L
A
K
D
L
K
E
E
I
K
R
Y
-
D
A
V
I-NA-NP
I
D
F
Q
I
L
G
IGRNGHIGFNEPGTP
F
D
I
T
T
H
V
VDLAPSTI-E
A
N
S
R
F
F
-
N
S
-
I
-
D
D
V
P
K
Q
A
L
S
M
G
I
G
S
IMKS
K
T
I
V
L
V
AYGI
E
K
A
E
A
I
A
S
M
I
KGPITEDM
P
A
S
I
L
QKHD
D
V
V
I
I
V
D
E
A
AASKL
1
PsiBlast_PDB
96.92
63%
-108
- C1 -
2RI0
1
NAGB_STRMU
A:
[2-232]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
E
E
I
-----
T
-----
F
G
-
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
----
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
---
A
A
K
--
P
F
K
K
S
Y
--
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
-
D
Q
I
L
-
A
Q
-
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
-
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
21
PsiBlast_CBE
96.36
63%
-108
- C1 -
2RI0
3
NAGB_STRMU
B:
[2-232]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
E
E
I
-----
T
-----
F
G
-
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
----
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
---
A
A
K
--
P
F
K
K
S
Y
--
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
-
D
Q
I
L
-
A
Q
-
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
-
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
22
PsiBlast_CBE
96.00
63%
-106
- C1 -
2RI1
2
NAGB_STRMU
B:
[3-233]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
E
E
I
-----
T
-----
F
G
-
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
----
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
---
A
A
K
--
P
F
K
K
S
Y
--
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
-
D
Q
I
L
-
A
Q
-
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
-
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
2
PsiBlast_PDB
95.34
63%
-107
- C1 -
2RI1
2
NAGB_STRMU
A:
[3-233]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
E
E
I
-----
T
-----
F
G
-
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
----
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
---
A
A
K
--
P
F
K
K
S
Y
--
L
P
N
G
L
A
A
D
L
A
K
E
T
E
Y
Y
-
D
Q
I
L
-
A
Q
-
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
-
A
A
N
S
R
F
F
-
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
59
HHSearch
92.09
59%
-99
- C1 -
2RI0
1
NAGB_STRMU
A:
[2-234]
M
K
T
I
K
V
K
N
K
T
E
G
S
K
V
A
F
R
M
L
E
E
E
I
-----
T
-----
F
G
-
A
K
T
------
L
G
L
A
T
G
S
T
P
L
E
L
Y
K
E
I
R
E
----
S
----
H
L
D
F
S
D
M
V
S
I
N
L
D
E
Y
V
G
L
S
A
D
D
K
Q
S
Y
A
Y
F
M
K
Q
N
L
F
---
A
A
K
PF
K
K
S
Y
L
P
--
N
G
L
A
-
A
D
L
-
A
K
E
T
E
Y
Y
-
D
Q
I
L
A
Q
--
Y
P
I
D
L
Q
I
L
G
I
G
R
N
A
H
I
G
F
N
E
P
G
T
A
F
S
S
Q
T
H
L
V
D
L
T
P
S
T
I
A
A
N
-
S
R
F
F
-
E
K
-
A
-
E
D
V
P
K
Q
A
I
S
M
G
L
A
S
I
M
S
A
K
M
I
L
L
M
A
F
G
E
E
K
A
E
A
V
A
A
M
V
K
G
P
V
T
E
E
I
P
A
S
I
L
Q
T
H
P
K
V
I
L
I
V
D
E
K
A
G
A
G
I
24
PsiBlast_CBE
86.58
43%
-102
- C1 -
2BKV
1
NAGB_BACSU
B:
[1-239]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
D
T
I
-----
K
-----
E
K
-
P
D
A
V-----
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
LHQT
E
----
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
QHI
D
S
K
--
P
S
R
-
H
F
--
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
-
E
Q
L
V
-
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
-
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
58
HHSearch
85.96
44%
-98
- C1 -
2BKX
1
NAGB_BACSU
A:
[1-241]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
D
T
I
-----
K
-----
E
K
P
D
A
V
------
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
----
L
H
Q
T
E
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
---
Q
H
I
DS
K
P
S
R
H
F
--
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
-
E
Q
L
V
D
S
L
-
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
-
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
3
PsiBlast_PDB
85.35
43%
-100
- C1 -
2BKV
1
NAGB_BACSU
A:
[1-239]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
D
T
I
-----
K
-----
E
K
-
P
D
A
V
-----
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
----
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
QHI
D
S
K
--
P
S
R
-
H
F
--
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
-
E
Q
L
V
-
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
-
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
4
PsiBlast_PDB
85.11
43%
-99
- C1 -
2BKX
1
NAGB_BACSU
A:
[1-239]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
D
T
I
-----
K
-----
E
K
-
P
D
A
V
-----
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
L
H
Q
T
E
----
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
QHI
D
S
K
--
P
S
R
-
H
F
--
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
-
E
Q
L
V
-
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
-
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
23
PsiBlast_CBE
84.92
43%
-98
- C1 -
2BKX
1
NAGB_BACSU
B:
[1-239]
M
K
V
M
E
C
Q
T
Y
E
E
L
S
Q
I
A
A
R
I
T
A
D
T
I
-----
K
-----
E
K
-
P
D
A
V-----
L
G
L
A
T
G
G
T
P
E
G
T
Y
R
Q
L
I
R
LHQT
E
----
N
L
S
F
Q
N
I
T
T
V
N
L
D
E
Y
A
G
L
S
S
D
D
P
N
S
Y
H
F
Y
M
N
D
R
F
F
QHI
D
S
K
--
P
S
R
-
H
F
--
I
P
N
G
N
A
D
D
L
E
A
E
C
R
R
Y
-
E
Q
L
V
-
D
S
L
G
D
T
D
I
Q
L
L
G
I
G
R
N
G
H
I
G
F
N
E
P
G
T
S
F
K
S
R
T
H
V
V
T
L
N
E
Q
T
R
-
Q
A
N
A
R
Y
F
-
P
S
-
I
-
D
S
V
P
K
K
A
L
T
M
G
I
Q
T
I
L
S
S
K
R
I
L
L
L
I
S
G
K
S
K
A
E
A
V
R
K
L
L
E
G
N
I
S
E
D
F
P
A
S
A
L
H
L
H
S
D
V
T
V
L
I
D
R
E
A
A
S
L
R
32
PsiBlast_CBE
84.86
33%
-111
- C1 -
4R7T
2
NAGB_VIBCH
C:
[1-247]
M
R
L
I
P
L
K
A
A
A
Q
V
G
K
W
A
A
A
H
I
V
K
R
I
-----
N
-----
E
F
-
Q
P
T
AE
R
P
F
V
L
G
L
P
T
G
G
T
P
L
A
T
Y
K
A
L
I
E
M
H
K
A
G
----
E
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
A
A
D
H
P
E
S
Y
R
S
F
M
Y
N
N
F
F
---
N
H
I
--
D
I
Q
E
E
N
I
N
L
L
N
G
N
T
D
D
H
E
A
E
C
K
R
Y
E
D
K
I
K
-
S
Y
-
G
K
I
N
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
S
S
R
T
R
I
K
T
L
T
E
D
T
R
-
I
A
N
S
R
F
F
-
D
--
I
-
N
Q
V
P
K
Y
A
L
T
I
G
V
G
T
L
L
D
A
Q
E
I
M
I
L
V
T
G
H
N
K
A
L
A
L
Q
A
A
V
E
G
S
V
N
H
L
W
T
V
S
A
L
Q
L
H
P
K
A
V
I
V
C
D
E
P
S
T
Q
E
L
13
PsiBlast_PDB
84.49
32%
-104
- C1 -
1FSF
-
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
33
PsiBlast_CBE
84.31
33%
-113
- C1 -
4R7T
2
NAGB_VIBCH
B:
[1-247]
M
R
L
I
P
L
K
A
A
A
Q
V
G
K
W
A
A
A
H
I
V
K
R
I
-----
N
-----
E
F
-
Q
P
T
AE
R
P
F
V
L
G
L
P
T
G
G
T
P
L
A
T
Y
K
A
L
I
E
M
H
K
A
G
----
E
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
A
A
D
H
P
E
S
Y
R
S
F
M
Y
N
N
F
F
---
N
H
I
--
D
I
Q
E
E
N
I
N
L
L
N
G
N
T
D
D
H
E
A
E
C
K
R
Y
E
D
K
I
K
-
S
Y
-
G
K
I
N
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
S
S
R
T
R
I
K
T
L
T
E
D
T
R
-
I
A
N
S
-
F
F
-
D
G
D
I
-
N
Q
V
P
K
Y
A
L
T
I
G
V
G
T
L
L
D
A
Q
E
I
M
I
L
V
T
G
H
N
K
A
L
A
L
Q
A
A
V
E
G
S
V
N
H
L
W
T
V
S
A
L
Q
L
H
P
K
A
V
I
V
C
D
E
P
S
T
Q
E
L
60
HHSearch
83.94
36%
-104
- C1 -
3HN6
1
NAGB_BORBU
A:
[22-268]
M
R
L
I
I
R
P
T
Y
E
D
I
S
K
W
A
A
N
H
V
A
Q
K
I
-----
N
E
F
SPT
K
E
N
P
F
I
------
L
G
L
P
T
G
S
S
P
I
G
M
Y
K
N
L
I
E
----
L
N
K
N
K
K
I
S
F
Q
N
V
I
T
F
N
M
D
E
Y
I
G
I
E
E
N
H
P
E
S
Y
H
S
F
M
W
N
N
F
F
---
S
H
I
DI
K
K
E
N
I
N
--
I
L
N
G
N
A
S
N
L
K
K
E
C
E
E
Y
-
E
K
K
I
K
S
F
-
G
G
I
M
L
F
V
G
G
I
G
P
D
G
H
I
A
F
N
E
P
G
S
S
L
T
S
R
T
R
I
K
T
L
T
Q
D
T
I
-
I
A
N
S
R
F
F
-
E
G
-
D
V
N
K
V
P
K
N
A
L
T
V
G
I
G
T
I
M
D
S
Q
E
V
L
I
I
V
N
G
H
N
K
A
R
A
L
K
H
A
I
E
K
G
V
N
H
M
W
T
I
S
A
L
Q
L
H
K
N
A
I
I
V
S
D
K
N
A
T
Y
E
L
25
PsiBlast_CBE
83.26
32%
-108
- C1 -
2WU1
2
NAGB_ECOLI
B:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
ADRPFV
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
MHKA
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
34
PsiBlast_CBE
83.22
33%
-112
- C1 -
4R7T
2
NAGB_VIBCH
A:
[1-247]
M
R
L
I
P
L
K
A
A
A
Q
V
G
K
W
A
A
A
H
I
V
K
R
I
-----
N
-----
E
F
-
Q
P
T
AE
R
P
F
V
L
G
L
P
T
G
G
T
P
L
A
T
Y
K
A
L
I
E
M
H
K
A
G
----
E
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
A
A
D
H
P
E
S
Y
R
S
F
M
Y
N
N
F
F
---
N
H
I
--
D
I
Q
E
E
N
I
N
L
L
N
G
N
T
D
D
H
E
A
E
C
K
R
Y
E
D
K
I
K
-
S
Y
-
G
K
I
N
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
S
S
R
T
R
I
K
T
L
T
E
D
T
R
-
I
A
N
S
R
F
F
-
D
G
D
I
-
N
Q
V
P
K
Y
A
L
T
I
G
V
G
T
L
L
D
A
Q
E
I
M
I
L
V
T
G
H
N
K
A
L
A
L
Q
A
A
V
E
G
S
V
N
H
L
W
T
V
S
A
L
Q
L
H
P
K
A
V
I
V
C
D
E
P
S
T
Q
E
L
8
PsiBlast_PDB
82.99
32%
-104
- C1 -
1CD5
-
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
31
PsiBlast_CBE
82.84
32%
-106
- C1 -
1DEA
2
NAGB_ECOLI
B:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
ADRPFV
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
MHKA
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
9
PsiBlast_PDB
82.72
32%
-105
- C1 -
1FQO
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
6
PsiBlast_PDB
82.69
32%
-104
- C1 -
1DEA
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
30
PsiBlast_CBE
82.06
32%
-107
- C1 -
1FQO
2
NAGB_ECOLI
B:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
ADRPFV
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
MHKA
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
14
PsiBlast_PDB
82.00
32%
-104
- C1 -
2WU1
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
57
HHSearch
81.95
34%
-101
- C1 -
1FS5
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
N
A
F
KP
T
-----
A
D
R
P
F
V
------
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
----
M
H
K
A
G
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
R
S
Y
-
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
-
D
N
-
D
V
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
27
PsiBlast_CBE
81.81
32%
-102
- C1 -
1HOR
2
NAGB_ECOLI
B:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
ADRPFV
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
MHKA
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
11
PsiBlast_PDB
81.67
32%
-104
- C1 -
1FS5
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L
5
PsiBlast_PDB
80.84
32%
-103
- C1 -
1HOR
2
NAGB_ECOLI
A:
[1-247]
M
R
L
I
P
L
T
T
A
E
Q
V
G
K
W
A
A
R
H
I
V
N
R
I
-----
N
-----
A
F
-
K
P
T
AD
R
P
F
V
L
G
L
P
T
G
G
T
P
M
T
T
Y
K
A
L
V
E
M
H
K
A
G
----
Q
V
S
F
K
H
V
V
T
F
N
M
D
E
Y
V
G
L
P
K
E
H
P
E
S
Y
Y
S
F
M
H
R
N
F
F
---
D
H
V
DI
P
A
E
N
I
N
--
L
L
N
G
N
A
P
D
I
D
A
E
C
R
Q
Y
-
E
E
K
I
-
R
S
Y
G
K
I
H
L
F
M
G
G
V
G
N
D
G
H
I
A
F
N
E
P
A
S
S
L
A
S
R
T
R
I
K
T
L
T
H
D
T
R
-
V
A
N
S
R
F
F
D
N
D
-
V
-
N
Q
V
P
K
Y
A
L
T
V
G
V
G
T
L
L
D
A
E
E
V
M
I
L
V
L
G
S
Q
K
A
L
A
L
Q
A
A
V
E
G
C
V
N
H
M
W
T
I
S
C
L
Q
L
H
P
K
A
I
M
V
C
D
E
P
S
T
M
E
L